Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

54670067 78200 96 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assayAgonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay
ChEMBL 176 2 4 6 -1.4 O=C1O[C@H]([C@@H](O)CO)C(O)=C1O 10.1016/j.bmc.2009.01.065
CHEMBL196 78200 96 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assayAgonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay
ChEMBL 176 2 4 6 -1.4 O=C1O[C@H]([C@@H](O)CO)C(O)=C1O 10.1016/j.bmc.2009.01.065
11360447 91776 0 None -23 3 Human 6.0 pEC50 = 6 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 272 4 1 4 3.2 CC(Oc1ccccc1-c1cccs1)C1=NCCN1 10.1021/jm0408215
CHEMBL223829 91776 0 None -23 3 Human 6.0 pEC50 = 6 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 272 4 1 4 3.2 CC(Oc1ccccc1-c1cccs1)C1=NCCN1 10.1021/jm0408215
11265631 143187 0 None -22 3 Human 6.0 pEC50 = 6 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 10.1021/jm0408215
CHEMBL373535 143187 0 None -22 3 Human 6.0 pEC50 = 6 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 10.1021/jm0408215
44371864 57915 0 None -85 3 Human 6.0 pEC50 = 6 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 246 5 1 3 2.6 CCc1cccc(CC)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL157955 57915 0 None -85 3 Human 6.0 pEC50 = 6 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 246 5 1 3 2.6 CCc1cccc(CC)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
2765 7730 19 None -95 7 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/jm901262f
515 7730 19 None -95 7 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/jm901262f
CHEMBL13852 7730 19 None -95 7 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/jm901262f
DB09202 7730 19 None -95 7 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/jm901262f
45487145 204438 0 None -19 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 230 4 1 3 2.5 C=CCc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
CHEMBL570973 204438 0 None -19 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 230 4 1 3 2.5 C=CCc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
45487956 205146 0 None -25 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 230 3 1 3 2.6 CC(OC1=NCCN1)c1ccccc1C1CC1 10.1021/jm901262f
CHEMBL576623 205146 0 None -25 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 230 3 1 3 2.6 CC(OC1=NCCN1)c1ccccc1C1CC1 10.1021/jm901262f
49836301 25339 1 None -39 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/ml300064v
CHEMBL1276140 25339 1 None -39 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/ml300064v
49836301 25339 1 None -39 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/jm100977d
CHEMBL1276140 25339 1 None -39 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/jm100977d
49836305 25348 0 None -158 3 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 272 4 1 4 3.2 C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1 10.1021/jm100977d
CHEMBL1276248 25348 0 None -158 3 Human 6.0 pEC50 = 6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 272 4 1 4 3.2 C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1 10.1021/jm100977d
11265631 143187 0 None -22 3 Human 6.0 pEC50 = 6 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 10.1021/jm061487a
CHEMBL373535 143187 0 None -22 3 Human 6.0 pEC50 = 6 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 10.1021/jm061487a
44371745 56063 0 None -100 2 Human 5.0 pEC50 = 5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 218 4 1 3 2.0 CCc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL156336 56063 0 None -100 2 Human 5.0 pEC50 = 5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 218 4 1 3 2.0 CCc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
57400959 77963 0 None -31 3 Human 5.0 pEC50 = 5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 268 4 1 5 0.9 CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956200 77963 0 None -31 3 Human 5.0 pEC50 = 5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 268 4 1 5 0.9 CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1 10.1016/j.bmc.2012.01.035
57402717 77962 2 None -10 2 Human 4.0 pEC50 = 4 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 220 4 1 4 1.5 COc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956199 77962 2 None -10 2 Human 4.0 pEC50 = 4 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 220 4 1 4 1.5 COc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
11043720 98947 0 None -891 3 Human 4.0 pEC50 = 4 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 266 4 1 3 3.1 C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
CHEMBL242265 98947 0 None -891 3 Human 4.0 pEC50 = 4 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 266 4 1 3 3.1 C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
11043720 98947 0 None -891 3 Human 4.0 pEC50 = 4 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 266 4 1 3 3.1 C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
CHEMBL242265 98947 0 None -891 3 Human 4.0 pEC50 = 4 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 266 4 1 3 3.1 C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
9795515 211599 0 None - 1 Rat 6.0 pEC50 = 6.0 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 273 3 2 3 4.1 COc1c(C(C)(C)C)cc(C)c(Nc2ncc[nH]2)c1C 10.1021/jm9605142
CHEMBL75257 211599 0 None - 1 Rat 6.0 pEC50 = 6.0 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 273 3 2 3 4.1 COc1c(C(C)(C)C)cc(C)c(Nc2ncc[nH]2)c1C 10.1021/jm9605142
2803 7742 58 None -14 14 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm100977d
516 7742 58 None -14 14 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm100977d
704 7742 58 None -14 14 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm100977d
CHEMBL134 7742 58 None -14 14 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm100977d
DB00575 7742 58 None -14 14 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm100977d
1593 9119 66 None -12 6 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1016/j.bmc.2012.01.035
30668 9119 66 None -12 6 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1016/j.bmc.2012.01.035
9868 9119 66 None -12 6 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1016/j.bmc.2012.01.035
CHEMBL17860 9119 66 None -12 6 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1016/j.bmc.2012.01.035
DB04948 9119 66 None -12 6 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1016/j.bmc.2012.01.035
24906201 194132 0 None -15 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2cccc3c2OCC(C2=NCCN2)O3)cc1 10.1021/jm800250z
CHEMBL493272 194132 0 None -15 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2cccc3c2OCC(C2=NCCN2)O3)cc1 10.1021/jm800250z
57345629 77960 0 None -269 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 246 5 1 4 2.0 CC(Oc1ccccc1OC1CC1)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956197 77960 0 None -269 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 246 5 1 4 2.0 CC(Oc1ccccc1OC1CC1)C1=NCCN1 10.1016/j.bmc.2012.01.035
44371755 55551 0 None -79 3 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 218 3 1 3 2.1 Cc1cccc(C)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL155866 55551 0 None -79 3 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 218 3 1 3 2.1 Cc1cccc(C)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
57345627 77957 0 None -13 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 230 4 1 3 2.5 C=C(C)c1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956194 77957 0 None -13 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 230 4 1 3 2.5 C=C(C)c1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
70695474 84447 0 None -794 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
ChEMBL 244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
CHEMBL2089156 84447 0 None -794 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
ChEMBL 244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
24906242 194026 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 310 3 1 5 2.5 COC1(C2=NCCN2)COc2c(cccc2-c2ccccc2)O1 10.1021/jm800250z
CHEMBL492647 194026 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 310 3 1 5 2.5 COC1(C2=NCCN2)COc2c(cccc2-c2ccccc2)O1 10.1021/jm800250z
57345625 77954 0 None 1 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 224 3 1 3 2.1 CC(Oc1ccccc1Cl)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956191 77954 0 None 1 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 224 3 1 3 2.1 CC(Oc1ccccc1Cl)C1=NCCN1 10.1016/j.bmc.2012.01.035
2803 7742 58 None -14 14 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/0960-894X(94)85032-1
516 7742 58 None -14 14 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/0960-894X(94)85032-1
704 7742 58 None -14 14 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/0960-894X(94)85032-1
CHEMBL134 7742 58 None -14 14 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/0960-894X(94)85032-1
DB00575 7742 58 None -14 14 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/0960-894X(94)85032-1
3086326 211310 22 None -74 3 Human 6.8 pEC50 = 6.8 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 247 1 2 5 1.7 Clc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL72753 211310 22 None -74 3 Human 6.8 pEC50 = 6.8 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 247 1 2 5 1.7 Clc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
44269140 40327 0 None -17 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 248 5 1 4 2.2 CC(C)Oc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL14208 40327 0 None -17 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 248 5 1 4 2.2 CC(C)Oc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
57395732 77966 0 None -2 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 342 5 1 3 4.8 CC(Oc1c(-c2ccccc2)cccc1-c1ccccc1)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956203 77966 0 None -2 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 342 5 1 3 4.8 CC(Oc1c(-c2ccccc2)cccc1-c1ccccc1)C1=NCCN1 10.1016/j.bmc.2012.01.035
23622576 179551 0 None -9 3 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 272 4 1 3 3.5 CC(Oc1ccccc1C1CCCCC1)C1=NCCN1 10.1021/jm800250z
CHEMBL451229 179551 0 None -9 3 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 272 4 1 3 3.5 CC(Oc1ccccc1C1CCCCC1)C1=NCCN1 10.1021/jm800250z
294234 109670 3 None -5 3 Human 6.7 pEC50 = 6.7 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 182 1 1 3 1.7 C1CCCC(NC2=NCCO2)CC1 10.1016/0960-894X(94)85032-1
CHEMBL305928 109670 3 None -5 3 Human 6.7 pEC50 = 6.7 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 182 1 1 3 1.7 C1CCCC(NC2=NCCO2)CC1 10.1016/0960-894X(94)85032-1
24906241 199596 0 None -7 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2cccc3c2OC(C2=NCCN2)CO3)cc1 10.1021/jm800250z
CHEMBL522151 199596 0 None -7 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2cccc3c2OC(C2=NCCN2)CO3)cc1 10.1021/jm800250z
57395663 77956 0 None 3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 258 3 1 3 2.5 CC(Oc1ccccc1C(F)(F)F)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956193 77956 0 None 3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 258 3 1 3 2.5 CC(Oc1ccccc1C(F)(F)F)C1=NCCN1 10.1016/j.bmc.2012.01.035
44269089 103780 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 232 4 1 3 2.6 CC(Oc1ccccc1C(C)C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL266613 103780 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 232 4 1 3 2.6 CC(Oc1ccccc1C(C)C)C1=NCCN1 10.1016/j.bmc.2012.01.035
45487958 205170 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 190 2 1 3 1.5 Cc1ccccc1COC1=NCCN1 10.1021/jm901262f
CHEMBL576819 205170 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 190 2 1 3 1.5 Cc1ccccc1COC1=NCCN1 10.1021/jm901262f
2435 7509 100 None -26 10 Human 6.6 pEC50 = 6.6 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
395 7509 100 None -26 10 Human 6.6 pEC50 = 6.6 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
520 7509 100 None -26 10 Human 6.6 pEC50 = 6.6 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
5386 7509 100 None -26 10 Human 6.6 pEC50 = 6.6 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
CHEMBL844 7509 100 None -26 10 Human 6.6 pEC50 = 6.6 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
DB00484 7509 100 None -26 10 Human 6.6 pEC50 = 6.6 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
57395731 77965 0 None -4 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 232 4 1 4 1.7 CC(=O)c1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956202 77965 0 None -4 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 232 4 1 4 1.7 CC(=O)c1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
218362 211579 5 None -3 3 Human 8.5 pEC50 = 8.5 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 216 1 1 3 2.0 c1ccc2c(c1)CCCC2NC1=NCCO1 10.1016/0960-894X(94)85032-1
CHEMBL75030 211579 5 None -3 3 Human 8.5 pEC50 = 8.5 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 216 1 1 3 2.0 c1ccc2c(c1)CCCC2NC1=NCCO1 10.1016/0960-894X(94)85032-1
135453290 140384 33 None -1513 7 Human 5.5 pEC50 = 5.5 Functional
Activity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assayActivity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assay
ChEMBL 191 2 2 4 1.1 C[C@H](N)Cn1ncc2ccc(O)cc21 10.1021/jm050663x
CHEMBL371300 140384 33 None -1513 7 Human 5.5 pEC50 = 5.5 Functional
Activity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assayActivity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assay
ChEMBL 191 2 2 4 1.1 C[C@H](N)Cn1ncc2ccc(O)cc21 10.1021/jm050663x
57345626 77955 2 None -31 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956192 77955 2 None -31 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1 10.1016/j.bmc.2012.01.035
57402718 77964 2 None -10 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 218 4 1 4 1.3 CC(Oc1ccccc1C=O)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956201 77964 2 None -10 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 218 4 1 4 1.3 CC(Oc1ccccc1C=O)C1=NCCN1 10.1016/j.bmc.2012.01.035
57399145 77959 0 None 3 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 234 5 1 4 1.9 CCOc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956196 77959 0 None 3 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 234 5 1 4 1.9 CCOc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
57393922 77961 0 None -5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 232 5 1 4 2.0 C=COc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956198 77961 0 None -5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 232 5 1 4 2.0 C=COc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
45487955 205089 0 None -125 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 232 4 1 3 2.7 CCCc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
CHEMBL576078 205089 0 None -125 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 232 4 1 3 2.7 CCCc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
44549156 25342 0 None -79 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 230 4 1 3 2.3 CC(Oc1ccccc1C1CC1)C1=NCCN1 10.1021/jm100977d
CHEMBL1276218 25342 0 None -79 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 230 4 1 3 2.3 CC(Oc1ccccc1C1CC1)C1=NCCN1 10.1021/jm100977d
49836303 25344 1 None -89 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 230 4 1 3 2.3 C[C@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/jm100977d
CHEMBL1276220 25344 1 None -89 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 230 4 1 3 2.3 C[C@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/jm100977d
24906197 194445 0 None -8 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 323 7 1 5 3.0 CC(Oc1ccccc1/C=N/OCc1ccccc1)C1=NCCN1 10.1021/jm800250z
CHEMBL495097 194445 0 None -8 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 323 7 1 5 3.0 CC(Oc1ccccc1/C=N/OCc1ccccc1)C1=NCCN1 10.1021/jm800250z
57345628 77958 0 None -1659 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956195 77958 0 None -1659 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1016/j.bmc.2012.01.035
57345628 77958 0 None -1659 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
CHEMBL1956195 77958 0 None -1659 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
44314200 109729 0 None -1 3 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 230 1 1 3 2.4 c1ccc2c(c1)CCCC2NC1=NCCCO1 10.1016/0960-894X(94)85032-1
CHEMBL306377 109729 0 None -1 3 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 230 1 1 3 2.4 c1ccc2c(c1)CCCC2NC1=NCCCO1 10.1016/0960-894X(94)85032-1
11140033 27455 0 None -40 3 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 265 4 2 3 3.2 CC(Nc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm0408215
CHEMBL130884 27455 0 None -40 3 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 265 4 2 3 3.2 CC(Nc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm0408215
70693375 84446 0 None -12 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
ChEMBL 244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
CHEMBL2089155 84446 0 None -12 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
ChEMBL 244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
24906159 194184 12 None -31 3 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 233 4 2 5 1.3 CC(Oc1ccccc1/C=N/O)C1=NCCN1 10.1021/jm800250z
CHEMBL493675 194184 12 None -31 3 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 233 4 2 5 1.3 CC(Oc1ccccc1/C=N/O)C1=NCCN1 10.1021/jm800250z
10176999 110331 21 None -6 3 Rat 7.4 pEC50 = 7.4 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 231 2 2 4 2.2 Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2 10.1021/jm9605142
CHEMBL308570 110331 21 None -6 3 Rat 7.4 pEC50 = 7.4 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 231 2 2 4 2.2 Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2 10.1021/jm9605142
42636938 179203 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assayAgonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay
ChEMBL 387 0 2 5 1.4 NC1=N[C@]23CCCN2C(=O)c2cc(Br)c(Br)n2[C@@H]3N1 10.1016/j.bmc.2009.01.065
CHEMBL447696 179203 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assayAgonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay
ChEMBL 387 0 2 5 1.4 NC1=N[C@]23CCCN2C(=O)c2cc(Br)c(Br)n2[C@@H]3N1 10.1016/j.bmc.2009.01.065
9859437 174801 0 None -4 3 Rat 6.3 pEC50 = 6.3 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 230 2 3 4 2.3 Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2 10.1021/jm9605142
CHEMBL432155 174801 0 None -4 3 Rat 6.3 pEC50 = 6.3 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 230 2 3 4 2.3 Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2 10.1021/jm9605142
135399666 175542 7 None -54 6 Human 5.3 pEC50 = 5.3 Functional
Activity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assayActivity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assay
ChEMBL 191 2 2 4 1.1 C[C@@H](N)Cn1ncc2ccc(O)cc21 10.1021/jm050663x
CHEMBL437314 175542 7 None -54 6 Human 5.3 pEC50 = 5.3 Functional
Activity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assayActivity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assay
ChEMBL 191 2 2 4 1.1 C[C@@H](N)Cn1ncc2ccc(O)cc21 10.1021/jm050663x
44371744 57095 0 None -8 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 270 7 1 3 2.9 C=CCc1cccc(CC=C)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL157206 57095 0 None -8 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
ChEMBL 270 7 1 3 2.9 C=CCc1cccc(CC=C)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
24906199 194444 15 None -50 3 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 258 4 1 3 3.1 CC(Oc1ccccc1C1CCCC1)C1=NCCN1 10.1021/jm800250z
CHEMBL495096 194444 15 None -50 3 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 258 4 1 3 3.1 CC(Oc1ccccc1C1CCCC1)C1=NCCN1 10.1021/jm800250z
45487089 204419 0 None -79 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 204 2 1 3 2.0 Cc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
CHEMBL570863 204419 0 None -79 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 204 2 1 3 2.0 Cc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
11346584 143762 0 None -112 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm0408215
CHEMBL374584 143762 0 None -112 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm0408215
11346584 143762 0 None -112 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm100977d
CHEMBL374584 143762 0 None -112 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm100977d
11346584 143762 0 None -112 2 Human 5.3 pEC50 = 5.3 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm061487a
CHEMBL374584 143762 0 None -112 2 Human 5.3 pEC50 = 5.3 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm061487a
2435 7509 100 None -16 10 Rat 7.3 pEC50 = 7.3 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
395 7509 100 None -16 10 Rat 7.3 pEC50 = 7.3 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
520 7509 100 None -16 10 Rat 7.3 pEC50 = 7.3 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
5386 7509 100 None -16 10 Rat 7.3 pEC50 = 7.3 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
CHEMBL844 7509 100 None -16 10 Rat 7.3 pEC50 = 7.3 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
DB00484 7509 100 None -16 10 Rat 7.3 pEC50 = 7.3 Functional
Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cellsEffective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
44292232 108098 0 None -51 3 Human 6.3 pEC50 = 6.3 Functional
Alpha-2B adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2B adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
ChEMBL 222 3 1 3 2.2 CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1 10.1021/jm9905256
CHEMBL296660 108098 0 None -51 3 Human 6.3 pEC50 = 6.3 Functional
Alpha-2B adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2B adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
ChEMBL 222 3 1 3 2.2 CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1 10.1021/jm9905256
1960 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm0408215
439260 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm0408215
505 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm0408215
CHEMBL1437 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm0408215
DB00368 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm0408215
45487962 204264 0 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 218 4 1 3 2.1 CCCc1ccccc1COC1=NCCN1 10.1021/jm901262f
CHEMBL569933 204264 0 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 218 4 1 3 2.1 CCCc1ccccc1COC1=NCCN1 10.1021/jm901262f
1960 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm800250z
439260 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm800250z
505 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm800250z
CHEMBL1437 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm800250z
DB00368 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm800250z
1960 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm061487a
439260 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm061487a
505 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm061487a
CHEMBL1437 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm061487a
DB00368 9632 67 None -2 19 Human 7.2 pEC50 = 7.2 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm061487a
44352207 25628 1 None -11 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm0408215
CHEMBL128168 25628 1 None -11 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm0408215
44352207 25628 1 None -11 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
CHEMBL128168 25628 1 None -11 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
44352207 25628 1 None -11 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm800250z
CHEMBL128168 25628 1 None -11 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cellsAgonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm800250z
44352207 25628 1 None -11 3 Human 6.2 pEC50 = 6.2 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
CHEMBL128168 25628 1 None -11 3 Human 6.2 pEC50 = 6.2 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
10333157 158017 0 None -37 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
CHEMBL396013 158017 0 None -37 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
ChEMBL 266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
10333157 158017 0 None -37 3 Human 6.2 pEC50 = 6.2 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
CHEMBL396013 158017 0 None -37 3 Human 6.2 pEC50 = 6.2 Functional
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
ChEMBL 266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
68712 107114 60 None -2 7 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 10.1016/0960-894X(94)85032-1
CHEMBL289480 107114 60 None -2 7 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 10.1016/0960-894X(94)85032-1
185076 193869 5 None -64 3 Human 7.1 pEC50 = 7.1 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL49137 193869 5 None -64 3 Human 7.1 pEC50 = 7.1 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
131829 211506 15 None -316 3 Human 6.1 pEC50 = 6.1 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 295 1 4 5 1.7 Brc1c(NC2=NCCN2)ccc2c1NCCN2 10.1016/0960-894X(95)00391-6
CHEMBL74283 211506 15 None -316 3 Human 6.1 pEC50 = 6.1 Functional
Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
ChEMBL 295 1 4 5 1.7 Brc1c(NC2=NCCN2)ccc2c1NCCN2 10.1016/0960-894X(95)00391-6
44314198 111189 0 None -5 3 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 210 3 1 3 2.3 CCC[C@H]1CCCCC1NC1=NCCO1 10.1016/0960-894X(94)85032-1
CHEMBL310335 111189 0 None -5 3 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
ChEMBL 210 3 1 3 2.3 CCC[C@H]1CCCCC1NC1=NCCO1 10.1016/0960-894X(94)85032-1
9815707 108246 0 None -5 3 Human 8.0 pEC50 = 8.0 Functional
Alpha-2B adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2B adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
ChEMBL 210 3 1 3 2.3 CCC[C@H]1CCCC[C@@H]1NC1=NCCO1 10.1021/jm9905256
CHEMBL297752 108246 0 None -5 3 Human 8.0 pEC50 = 8.0 Functional
Alpha-2B adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2B adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
ChEMBL 210 3 1 3 2.3 CCC[C@H]1CCCC[C@@H]1NC1=NCCO1 10.1021/jm9905256
44579228 188433 0 None - 0 Human 7.0 pKi = 7.0 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 467 7 2 7 2.9 CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
CHEMBL477608 188433 0 None - 0 Human 7.0 pKi = 7.0 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 467 7 2 7 2.9 CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
44579229 196395 0 None - 0 Human 7.9 pKi = 7.9 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 468 10 1 7 2.8 CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
CHEMBL514837 196395 0 None - 0 Human 7.9 pKi = 7.9 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 468 10 1 7 2.8 CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
44579185 188593 1 None - 0 Human 6.9 pKi = 6.9 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 488 8 1 7 3.5 O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1 10.1016/j.bmcl.2008.08.055
CHEMBL477816 188593 1 None - 0 Human 6.9 pKi = 6.9 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 488 8 1 7 3.5 O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1 10.1016/j.bmcl.2008.08.055
44579271 193873 0 None - 0 Human 6.9 pKi = 6.9 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 475 9 0 7 4.2 c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1 10.1016/j.bmcl.2008.08.055
CHEMBL491419 193873 0 None - 0 Human 6.9 pKi = 6.9 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 475 9 0 7 4.2 c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1 10.1016/j.bmcl.2008.08.055
44579230 188323 0 None - 0 Human 7.9 pKi = 7.9 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 468 10 1 7 2.8 CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1 10.1016/j.bmcl.2008.08.055
CHEMBL476569 188323 0 None - 0 Human 7.9 pKi = 7.9 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 468 10 1 7 2.8 CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1 10.1016/j.bmcl.2008.08.055
44579184 197732 4 None - 0 Human 7.8 pKi = 7.8 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 340 4 0 5 2.7 COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
CHEMBL518592 197732 4 None - 0 Human 7.8 pKi = 7.8 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 340 4 0 5 2.7 COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
10758200 70191 0 None - 0 Human 6.8 pKi = 6.8 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 322 4 0 3 3.2 c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1 10.1016/j.bmcl.2008.08.055
CHEMBL179648 70191 0 None - 0 Human 6.8 pKi = 6.8 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 322 4 0 3 3.2 c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1 10.1016/j.bmcl.2008.08.055
44579187 196458 0 None - 0 Human 7.6 pKi = 7.6 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 513 8 1 8 3.3 N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1 10.1016/j.bmcl.2008.08.055
CHEMBL515331 196458 0 None - 0 Human 7.6 pKi = 7.6 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 513 8 1 8 3.3 N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1 10.1016/j.bmcl.2008.08.055
25110718 200088 0 None - 0 Human 7.5 pKi = 7.5 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 488 8 1 7 3.5 O=C(NCCN1CCCN(C[C@H]2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1 10.1016/j.bmcl.2008.08.055
CHEMBL524153 200088 0 None - 0 Human 7.5 pKi = 7.5 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 488 8 1 7 3.5 O=C(NCCN1CCCN(C[C@H]2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1 10.1016/j.bmcl.2008.08.055
44579272 193874 0 None - 0 Human 8.3 pKi = 8.3 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 499 7 0 9 4.3 c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1 10.1016/j.bmcl.2008.08.055
CHEMBL491420 193874 0 None - 0 Human 8.3 pKi = 8.3 Functional
Antagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
ChEMBL 499 7 0 9 4.3 c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1 10.1016/j.bmcl.2008.08.055
1343 8670 62 None -2 12 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
3519 8670 62 None -2 12 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
522 8670 62 None -2 12 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
CHEMBL862 8670 62 None -2 12 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
DB01018 8670 62 None -2 12 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
2435 7509 100 None -26 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
395 7509 100 None -26 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
520 7509 100 None -26 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
5386 7509 100 None -26 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
CHEMBL844 7509 100 None -26 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
DB00484 7509 100 None -26 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
2683 10606 60 None -2 6 Human 7.0 pEC50 = 7 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
5487 10606 60 None -2 6 Human 7.0 pEC50 = 7 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
7308 10606 60 None -2 6 Human 7.0 pEC50 = 7 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
CHEMBL1079 10606 60 None -2 6 Human 7.0 pEC50 = 7 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
DB00697 10606 60 None -2 6 Human 7.0 pEC50 = 7 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
12574 9383 88 None -5 8 Human 7.1 pEC50 = 7.1 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
4810 9383 88 None -5 8 Human 7.1 pEC50 = 7.1 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
CHEMBL19236 9383 88 None -5 8 Human 7.1 pEC50 = 7.1 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
DB09242 9383 88 None -5 8 Human 7.1 pEC50 = 7.1 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
523 10878 93 None 1 5 Human 7.4 pEC50 = 7.4 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
5707 10878 93 None 1 5 Human 7.4 pEC50 = 7.4 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
CHEMBL297362 10878 93 None 1 5 Human 7.4 pEC50 = 7.4 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
DB11477 10878 93 None 1 5 Human 7.4 pEC50 = 7.4 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
1028 7079 71 None -25 19 Human 7.5 pEC50 = 7.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
139148732 7079 71 None -25 19 Human 7.5 pEC50 = 7.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
479 7079 71 None -25 19 Human 7.5 pEC50 = 7.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
5816 7079 71 None -25 19 Human 7.5 pEC50 = 7.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
CHEMBL679 7079 71 None -25 19 Human 7.5 pEC50 = 7.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
DB00668 7079 71 None -25 19 Human 7.5 pEC50 = 7.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
2435 7509 100 None -26 10 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
395 7509 100 None -26 10 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
520 7509 100 None -26 10 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
5386 7509 100 None -26 10 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
CHEMBL844 7509 100 None -26 10 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
DB00484 7509 100 None -26 10 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
1960 9632 67 None -2 19 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
439260 9632 67 None -2 19 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
505 9632 67 None -2 19 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
CHEMBL1437 9632 67 None -2 19 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
DB00368 9632 67 None -2 19 Human 7.8 pEC50 = 7.8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
2803 7742 58 None -14 14 Human 8.0 pEC50 = 8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
516 7742 58 None -14 14 Human 8.0 pEC50 = 8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
704 7742 58 None -14 14 Human 8.0 pEC50 = 8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
CHEMBL134 7742 58 None -14 14 Human 8.0 pEC50 = 8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
DB00575 7742 58 None -14 14 Human 8.0 pEC50 = 8 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
3952 8669 38 None 1 21 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5353646 8669 38 None 1 21 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5443 8669 38 None 1 21 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5702063 8669 38 None 1 21 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
CHEMBL1331786 8669 38 None 1 21 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
CHEMBL420 8669 38 None 1 21 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
1343 8670 62 None -2 12 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
3519 8670 62 None -2 12 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
522 8670 62 None -2 12 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
CHEMBL862 8670 62 None -2 12 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
DB01018 8670 62 None -2 12 Human 8.5 pEC50 = 8.5 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
521 8186 69 None 4 5 Human 9.2 pEC50 = 9.2 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
5311068 8186 69 None 4 5 Human 9.2 pEC50 = 9.2 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
835 8186 69 None 4 5 Human 9.2 pEC50 = 9.2 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
CHEMBL778 8186 69 None 4 5 Human 9.2 pEC50 = 9.2 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
DB00633 8186 69 None 4 5 Human 9.2 pEC50 = 9.2 Functional
ERK1/2 phosphorylationERK1/2 phosphorylation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
13181 6981 0 None - 1 Rat 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 306 2 2 4 3.1 N1=CC(=CC=C1)C2=C(C=CC(=C2)C(F)(F)F)NC=3NCCN3 25154730
71816200 6981 0 None - 1 Rat 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 306 2 2 4 3.1 N1=CC(=CC=C1)C2=C(C=CC(=C2)C(F)(F)F)NC=3NCCN3 25154730
1028 7079 71 None -25 19 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
139148732 7079 71 None -25 19 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
479 7079 71 None -25 19 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
5816 7079 71 None -25 19 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
CHEMBL679 7079 71 None -25 19 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
DB00668 7079 71 None -25 19 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
2683 10606 60 None -2 6 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
5487 10606 60 None -2 6 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
7308 10606 60 None -2 6 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
CHEMBL1079 10606 60 None -2 6 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
DB00697 10606 60 None -2 6 Human 6.3 pEC50 = 6.3 Functional
cAMP generationcAMP generation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
523 10878 93 None 1 5 Human 6.4 pEC50 = 6.4 Functional
cAMP generationcAMP generation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
5707 10878 93 None 1 5 Human 6.4 pEC50 = 6.4 Functional
cAMP generationcAMP generation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
CHEMBL297362 10878 93 None 1 5 Human 6.4 pEC50 = 6.4 Functional
cAMP generationcAMP generation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
DB11477 10878 93 None 1 5 Human 6.4 pEC50 = 6.4 Functional
cAMP generationcAMP generation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
12574 9383 88 None -5 8 Human 6.5 pEC50 = 6.5 Functional
cAMP generationcAMP generation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
4810 9383 88 None -5 8 Human 6.5 pEC50 = 6.5 Functional
cAMP generationcAMP generation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
CHEMBL19236 9383 88 None -5 8 Human 6.5 pEC50 = 6.5 Functional
cAMP generationcAMP generation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
DB09242 9383 88 None -5 8 Human 6.5 pEC50 = 6.5 Functional
cAMP generationcAMP generation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
1960 9632 67 None -2 19 Human 6.9 pEC50 = 6.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
439260 9632 67 None -2 19 Human 6.9 pEC50 = 6.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
505 9632 67 None -2 19 Human 6.9 pEC50 = 6.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
CHEMBL1437 9632 67 None -2 19 Human 6.9 pEC50 = 6.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
DB00368 9632 67 None -2 19 Human 6.9 pEC50 = 6.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
2435 7509 100 None -26 10 Human 7.2 pEC50 = 7.2 Functional
cAMP generationcAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
395 7509 100 None -26 10 Human 7.2 pEC50 = 7.2 Functional
cAMP generationcAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
520 7509 100 None -26 10 Human 7.2 pEC50 = 7.2 Functional
cAMP generationcAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
5386 7509 100 None -26 10 Human 7.2 pEC50 = 7.2 Functional
cAMP generationcAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
CHEMBL844 7509 100 None -26 10 Human 7.2 pEC50 = 7.2 Functional
cAMP generationcAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
DB00484 7509 100 None -26 10 Human 7.2 pEC50 = 7.2 Functional
cAMP generationcAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
2803 7742 58 None -14 14 Human 7.4 pEC50 = 7.4 Functional
cAMP generationcAMP generation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
516 7742 58 None -14 14 Human 7.4 pEC50 = 7.4 Functional
cAMP generationcAMP generation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
704 7742 58 None -14 14 Human 7.4 pEC50 = 7.4 Functional
cAMP generationcAMP generation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
CHEMBL134 7742 58 None -14 14 Human 7.4 pEC50 = 7.4 Functional
cAMP generationcAMP generation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
DB00575 7742 58 None -14 14 Human 7.4 pEC50 = 7.4 Functional
cAMP generationcAMP generation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
1343 8670 62 None -2 12 Human 7.6 pEC50 = 7.6 Functional
cAMP generationcAMP generation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
3519 8670 62 None -2 12 Human 7.6 pEC50 = 7.6 Functional
cAMP generationcAMP generation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
522 8670 62 None -2 12 Human 7.6 pEC50 = 7.6 Functional
cAMP generationcAMP generation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
CHEMBL862 8670 62 None -2 12 Human 7.6 pEC50 = 7.6 Functional
cAMP generationcAMP generation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
DB01018 8670 62 None -2 12 Human 7.6 pEC50 = 7.6 Functional
cAMP generationcAMP generation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
124 9755 47 None -17 25 Human 7.7 pEC50 = 7.7 Functional
cAMP generationcAMP generation
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
2032 9755 47 None -17 25 Human 7.7 pEC50 = 7.7 Functional
cAMP generationcAMP generation
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
4636 9755 47 None -17 25 Human 7.7 pEC50 = 7.7 Functional
cAMP generationcAMP generation
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
CHEMBL762 9755 47 None -17 25 Human 7.7 pEC50 = 7.7 Functional
cAMP generationcAMP generation
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
DB00935 9755 47 None -17 25 Human 7.7 pEC50 = 7.7 Functional
cAMP generationcAMP generation
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
3658 10879 53 None -1 18 Human 7.8 pEC50 = 7.8 Functional
cAMP generationcAMP generation
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
517 10879 53 None -1 18 Human 7.8 pEC50 = 7.8 Functional
cAMP generationcAMP generation
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
5709 10879 53 None -1 18 Human 7.8 pEC50 = 7.8 Functional
cAMP generationcAMP generation
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
CHEMBL312448 10879 53 None -1 18 Human 7.8 pEC50 = 7.8 Functional
cAMP generationcAMP generation
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
DB06694 10879 53 None -1 18 Human 7.8 pEC50 = 7.8 Functional
cAMP generationcAMP generation
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
3952 8669 38 None 1 21 Human 7.9 pEC50 = 7.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5353646 8669 38 None 1 21 Human 7.9 pEC50 = 7.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5443 8669 38 None 1 21 Human 7.9 pEC50 = 7.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5702063 8669 38 None 1 21 Human 7.9 pEC50 = 7.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
CHEMBL1331786 8669 38 None 1 21 Human 7.9 pEC50 = 7.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
CHEMBL420 8669 38 None 1 21 Human 7.9 pEC50 = 7.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
521 8186 69 None 4 5 Human 9.9 pEC50 = 9.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
5311068 8186 69 None 4 5 Human 9.9 pEC50 = 9.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
835 8186 69 None 4 5 Human 9.9 pEC50 = 9.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
CHEMBL778 8186 69 None 4 5 Human 9.9 pEC50 = 9.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
DB00633 8186 69 None 4 5 Human 9.9 pEC50 = 9.9 Functional
cAMP generationcAMP generation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
1427 8794 54 None -60 30 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
357 8794 54 None -60 30 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
3696 8794 54 None -60 30 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
CHEMBL11 8794 54 None -60 30 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
DB00458 8794 54 None -60 30 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
1225 8253 26 None -3 11 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 279 3 0 2 4.0 CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C None
3958 8253 26 None -3 11 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 279 3 0 2 4.0 CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C None
667477 8253 26 None -3 11 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 279 3 0 2 4.0 CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C None
CHEMBL860 8253 26 None -3 11 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 279 3 0 2 4.0 CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C None
DB01142 8253 26 None -3 11 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 279 3 0 2 4.0 CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C None
180 7189 56 None -56 38 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 7189 56 None -56 38 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 7189 56 None -56 38 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 7189 56 None -56 38 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 7189 56 None -56 38 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
521 8186 69 None 4 5 Human 10.9 pIC50 = 10.9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
5311068 8186 69 None 4 5 Human 10.9 pIC50 = 10.9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
835 8186 69 None 4 5 Human 10.9 pIC50 = 10.9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
CHEMBL778 8186 69 None 4 5 Human 10.9 pIC50 = 10.9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
DB00633 8186 69 None 4 5 Human 10.9 pIC50 = 10.9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
12574 9383 88 None -5 8 Human 7.5 pIC50 = 7.5 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
4810 9383 88 None -5 8 Human 7.5 pIC50 = 7.5 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
CHEMBL19236 9383 88 None -5 8 Human 7.5 pIC50 = 7.5 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
DB09242 9383 88 None -5 8 Human 7.5 pIC50 = 7.5 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
1028 7079 71 None -25 19 Human 7.6 pIC50 = 7.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
139148732 7079 71 None -25 19 Human 7.6 pIC50 = 7.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
479 7079 71 None -25 19 Human 7.6 pIC50 = 7.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
5816 7079 71 None -25 19 Human 7.6 pIC50 = 7.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
CHEMBL679 7079 71 None -25 19 Human 7.6 pIC50 = 7.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
DB00668 7079 71 None -25 19 Human 7.6 pIC50 = 7.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
523 10878 93 None 1 5 Human 7.7 pIC50 = 7.7 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
5707 10878 93 None 1 5 Human 7.7 pIC50 = 7.7 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
CHEMBL297362 10878 93 None 1 5 Human 7.7 pIC50 = 7.7 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
DB11477 10878 93 None 1 5 Human 7.7 pIC50 = 7.7 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
1960 9632 67 None -2 19 Human 7.8 pIC50 = 7.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
439260 9632 67 None -2 19 Human 7.8 pIC50 = 7.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
505 9632 67 None -2 19 Human 7.8 pIC50 = 7.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
CHEMBL1437 9632 67 None -2 19 Human 7.8 pIC50 = 7.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
DB00368 9632 67 None -2 19 Human 7.8 pIC50 = 7.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
2683 10606 60 None -2 6 Human 7.8 pIC50 = 7.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
5487 10606 60 None -2 6 Human 7.8 pIC50 = 7.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
7308 10606 60 None -2 6 Human 7.8 pIC50 = 7.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
CHEMBL1079 10606 60 None -2 6 Human 7.8 pIC50 = 7.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
DB00697 10606 60 None -2 6 Human 7.8 pIC50 = 7.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
2435 7509 100 None -26 10 Human 8.4 pIC50 = 8.4 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
395 7509 100 None -26 10 Human 8.4 pIC50 = 8.4 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
520 7509 100 None -26 10 Human 8.4 pIC50 = 8.4 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
5386 7509 100 None -26 10 Human 8.4 pIC50 = 8.4 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
CHEMBL844 7509 100 None -26 10 Human 8.4 pIC50 = 8.4 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
DB00484 7509 100 None -26 10 Human 8.4 pIC50 = 8.4 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
2803 7742 58 None -14 14 Human 8.6 pIC50 = 8.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
516 7742 58 None -14 14 Human 8.6 pIC50 = 8.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
704 7742 58 None -14 14 Human 8.6 pIC50 = 8.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
CHEMBL134 7742 58 None -14 14 Human 8.6 pIC50 = 8.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
DB00575 7742 58 None -14 14 Human 8.6 pIC50 = 8.6 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
1343 8670 62 None -2 12 Human 8.7 pIC50 = 8.7 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
3519 8670 62 None -2 12 Human 8.7 pIC50 = 8.7 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
522 8670 62 None -2 12 Human 8.7 pIC50 = 8.7 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
CHEMBL862 8670 62 None -2 12 Human 8.7 pIC50 = 8.7 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
DB01018 8670 62 None -2 12 Human 8.7 pIC50 = 8.7 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
124 9755 47 None -17 25 Human 8.8 pIC50 = 8.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
2032 9755 47 None -17 25 Human 8.8 pIC50 = 8.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
4636 9755 47 None -17 25 Human 8.8 pIC50 = 8.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
CHEMBL762 9755 47 None -17 25 Human 8.8 pIC50 = 8.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
DB00935 9755 47 None -17 25 Human 8.8 pIC50 = 8.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
3658 10879 53 None -1 18 Human 8.8 pIC50 = 8.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
517 10879 53 None -1 18 Human 8.8 pIC50 = 8.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
5709 10879 53 None -1 18 Human 8.8 pIC50 = 8.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
CHEMBL312448 10879 53 None -1 18 Human 8.8 pIC50 = 8.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
DB06694 10879 53 None -1 18 Human 8.8 pIC50 = 8.8 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
3952 8669 38 None 1 21 Human 9.0 pIC50 = 9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5353646 8669 38 None 1 21 Human 9.0 pIC50 = 9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5443 8669 38 None 1 21 Human 9.0 pIC50 = 9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5702063 8669 38 None 1 21 Human 9.0 pIC50 = 9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
CHEMBL1331786 8669 38 None 1 21 Human 9.0 pIC50 = 9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
CHEMBL420 8669 38 None 1 21 Human 9.0 pIC50 = 9 Functional
inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495




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5479537 73576 35 None - 0 Human 9.3 pAC50 = 9.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 480 7 2 10 -1.3 CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[N+]3(C)CCCC3)CS[C@H]12)c1csc(N)n1 10.1038/s41467-023-40064-9
CHEMBL186 73576 35 None - 0 Human 9.3 pAC50 = 9.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 480 7 2 10 -1.3 CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[N+]3(C)CCCC3)CS[C@H]12)c1csc(N)n1 10.1038/s41467-023-40064-9
46780481 114308 20 None -20 53 Human 8.9 pAC50 = 8.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 10.1038/s41467-023-40064-9
9903970 114308 20 None -20 53 Human 8.9 pAC50 = 8.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 10.1038/s41467-023-40064-9
CHEMBL3187365 114308 20 None -20 53 Human 8.9 pAC50 = 8.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 10.1038/s41467-023-40064-9
CHEMBL3544974 114308 20 None -20 53 Human 8.9 pAC50 = 8.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 10.1038/s41467-023-40064-9
2284 9956 33 None -3 29 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
4926 9956 33 None -3 29 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
7281 9956 33 None -3 29 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL564 9956 33 None -3 29 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00420 9956 33 None -3 29 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
2202 9906 96 None -1 21 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 10.1038/s41467-023-40064-9
4850 9906 96 None -1 21 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 10.1038/s41467-023-40064-9
49 9906 96 None -1 21 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 10.1038/s41467-023-40064-9
CHEMBL1371770 9906 96 None -1 21 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 10.1038/s41467-023-40064-9
DB12478 9906 96 None -1 21 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 10.1038/s41467-023-40064-9
22323 22071 32 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 287 2 5 2 2.9 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1 10.1038/s41467-023-40064-9
9571037 22071 32 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 287 2 5 2 2.9 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1213553 22071 32 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 287 2 5 2 2.9 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1 10.1038/s41467-023-40064-9
5357 105512 41 None - 3 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 7 1 5 1.7 CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC 10.1038/s41467-023-40064-9
CHEMBL277945 105512 41 None - 3 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 7 1 5 1.7 CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC 10.1038/s41467-023-40064-9
9417 140290 54 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 363 6 1 4 3.3 OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1 10.1038/s41467-023-40064-9
CHEMBL1524185 140290 54 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 363 6 1 4 3.3 OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1 10.1038/s41467-023-40064-9
CHEMBL370753 140290 54 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 363 6 1 4 3.3 OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1 10.1038/s41467-023-40064-9
2142 9870 58 None -5 37 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
4920903 9870 58 None -5 37 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
502 9870 58 None -5 37 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
5775 9870 58 None -5 37 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
CHEMBL597 9870 58 None -5 37 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
DB00692 9870 58 None -5 37 Human 7.0 pAC50 = 7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
2342 7386 39 None -1 6 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC 10.1038/s41467-023-40064-9
331 7386 39 None -1 6 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC 10.1038/s41467-023-40064-9
7124 7386 39 None -1 6 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC 10.1038/s41467-023-40064-9
CHEMBL1201250 7386 39 None -1 6 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC 10.1038/s41467-023-40064-9
DB00767 7386 39 None -1 6 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC 10.1038/s41467-023-40064-9
3294 8787 111 None -47 44 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
71360 8787 111 None -47 44 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
87 8787 111 None -47 44 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
CHEMBL14376 8787 111 None -47 44 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
DB04946 8787 111 None -47 44 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
5472 212597 75 None 1 3 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 10.1038/s41467-023-40064-9
CHEMBL1717 212597 75 None 1 3 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 10.1038/s41467-023-40064-9
CHEMBL833 212597 75 None 1 3 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 10.1038/s41467-023-40064-9
2762 10635 31 None - 2 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 3 2.7 CN(CCN(c1ccccn1)Cc1ccccc1)C 10.1038/s41467-023-40064-9
5587 10635 31 None - 2 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 3 2.7 CN(CCN(c1ccccn1)Cc1ccccc1)C 10.1038/s41467-023-40064-9
7318 10635 31 None - 2 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 3 2.7 CN(CCN(c1ccccn1)Cc1ccccc1)C 10.1038/s41467-023-40064-9
CHEMBL1241 10635 31 None - 2 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 3 2.7 CN(CCN(c1ccccn1)Cc1ccccc1)C 10.1038/s41467-023-40064-9
DB00792 10635 31 None - 2 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 3 2.7 CN(CCN(c1ccccn1)Cc1ccccc1)C 10.1038/s41467-023-40064-9
25382 15929 37 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL110094 15929 37 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
55645 91145 8 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 7 2 4 2.1 CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21 10.1038/s41467-023-40064-9
CHEMBL2218861 91145 8 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 7 2 4 2.1 CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21 10.1038/s41467-023-40064-9
CHEMBL502835 195291 0 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 539 7 2 7 3.6 COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 10.1038/s41467-023-40064-9
191 7191 98 None -30 29 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
201 7191 98 None -30 29 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170 7191 98 None -30 29 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
CHEMBL1113 7191 98 None -30 29 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
DB00543 7191 98 None -30 29 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
135398745 9688 112 None -37 65 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
47 9688 112 None -37 65 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
CHEMBL715 9688 112 None -37 65 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
DB00334 9688 112 None -37 65 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
2540 11173 111 None -1 4 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 11173 111 None -1 4 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
1960 9632 67 None -69 26 Human 7.9 pAC50 = 7.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
439260 9632 67 None -69 26 Human 7.9 pAC50 = 7.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
505 9632 67 None -69 26 Human 7.9 pAC50 = 7.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
CHEMBL1437 9632 67 None -69 26 Human 7.9 pAC50 = 7.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
DB00368 9632 67 None -69 26 Human 7.9 pAC50 = 7.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
102 10899 48 None -10 49 Human 7.9 pAC50 = 7.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
3659 10899 48 None -10 49 Human 7.9 pAC50 = 7.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
8969 10899 48 None -10 49 Human 7.9 pAC50 = 7.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
CHEMBL15245 10899 48 None -10 49 Human 7.9 pAC50 = 7.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
DB01392 10899 48 None -10 49 Human 7.9 pAC50 = 7.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
2286 9957 51 None -4 30 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C 10.1038/s41467-023-40064-9
4927 9957 51 None -4 30 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C 10.1038/s41467-023-40064-9
7282 9957 51 None -4 30 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C 10.1038/s41467-023-40064-9
CHEMBL643 9957 51 None -4 30 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C 10.1038/s41467-023-40064-9
DB01069 9957 51 None -4 30 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C 10.1038/s41467-023-40064-9
1524 8962 96 None -27 51 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
197 8962 96 None -27 51 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
3822 8962 96 None -27 51 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
88 8962 96 None -27 51 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
CHEMBL51 8962 96 None -27 51 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
DB12465 8962 96 None -27 51 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
11980903 21264 19 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
22526 21264 19 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5281035 21264 19 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201303 21264 19 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
51755 64180 54 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1651990 64180 54 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
4413 104849 57 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 347 4 5 4 2.6 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 10.1038/s41467-023-40064-9
CHEMBL273264 104849 57 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 347 4 5 4 2.6 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 10.1038/s41467-023-40064-9
135398735 143746 32 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
136262914 143746 32 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL374478 143746 32 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
2389 10104 118 None -104 66 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
5073 10104 118 None -104 66 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
96 10104 118 None -104 66 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
CHEMBL85 10104 118 None -104 66 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
DB00734 10104 118 None -104 66 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
2419 10236 84 None - 6 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
5152 10236 84 None - 6 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
559 10236 84 None - 6 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
CHEMBL1263 10236 84 None - 6 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
DB00938 10236 84 None - 6 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
7029 20441 19 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 205 5 0 2 2.6 CCN(CC)C(C)C(=O)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1194666 20441 19 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 205 5 0 2 2.6 CCN(CC)C(C)C(=O)c1ccccc1 10.1038/s41467-023-40064-9
2782 38774 67 None - 1 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 325 4 0 3 4.3 Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1 10.1038/s41467-023-40064-9
CHEMBL1407943 38774 67 None - 1 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 325 4 0 3 4.3 Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1 10.1038/s41467-023-40064-9
CHEMBL3216363 38774 67 None - 1 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 325 4 0 3 4.3 Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1 10.1038/s41467-023-40064-9
3547 148151 71 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 2 1 4 1.2 O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 10.1038/s41467-023-40064-9
CHEMBL38380 148151 71 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 2 1 4 1.2 O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 10.1038/s41467-023-40064-9
CHEMBL541388 148151 71 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 2 1 4 1.2 O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 10.1038/s41467-023-40064-9
2407 10145 76 None - 7 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
59227 10145 76 None - 7 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
941 10145 76 None - 7 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
CHEMBL1303 10145 76 None - 7 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
DB05271 10145 76 None - 7 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
5284550 48495 15 None -1 9 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 295 3 0 2 4.7 CN(C)CC/C=C1\c2ccccc2CSc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1492500 48495 15 None -1 9 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 295 3 0 2 4.7 CN(C)CC/C=C1\c2ccccc2CSc2ccccc21 10.1038/s41467-023-40064-9
16351 109507 47 None - 6 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 343 0 0 4 4.1 CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1038/s41467-023-40064-9
CHEMBL304902 109507 47 None - 6 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 343 0 0 4 4.1 CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1038/s41467-023-40064-9
2179 174297 76 None - 0 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 393 5 2 5 4.5 COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 10.1038/s41467-023-40064-9
CHEMBL1256655 174297 76 None - 0 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 393 5 2 5 4.5 COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 10.1038/s41467-023-40064-9
CHEMBL43 174297 76 None - 0 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 393 5 2 5 4.5 COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 10.1038/s41467-023-40064-9
209 9831 97 None -38 23 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
2113 9831 97 None -38 23 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
4748 9831 97 None -38 23 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL567 9831 97 None -38 23 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00850 9831 97 None -38 23 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
5365247 145207 33 None - 1 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 316 4 0 2 3.8 CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1 10.1038/s41467-023-40064-9
CHEMBL37744 145207 33 None - 1 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 316 4 0 2 3.8 CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1 10.1038/s41467-023-40064-9
1816 9318 102 None -851 18 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1038/s41467-023-40064-9
4205 9318 102 None -851 18 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1038/s41467-023-40064-9
7241 9318 102 None -851 18 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1038/s41467-023-40064-9
CHEMBL654 9318 102 None -851 18 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1038/s41467-023-40064-9
DB00370 9318 102 None -851 18 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1038/s41467-023-40064-9
104870 105656 47 None -3 21 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 10.1038/s41467-023-40064-9
5374 105656 47 None -3 21 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 10.1038/s41467-023-40064-9
CHEMBL279085 105656 47 None -3 21 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 10.1038/s41467-023-40064-9
30323 69259 57 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL1563 69259 57 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL178 69259 57 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
70691408 84987 0 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 326 1 2 4 1.6 CCC1C2CC3C4N(C)c5ccccc5C45CC(C2[C@H]5O)N3C1O 10.1038/s41467-023-40064-9
CHEMBL2105617 84987 0 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 326 1 2 4 1.6 CCC1C2CC3C4N(C)c5ccccc5C45CC(C2[C@H]5O)N3C1O 10.1038/s41467-023-40064-9
1613 9127 53 None -7 44 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
205 9127 53 None -7 44 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
3964 9127 53 None -7 44 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL831 9127 53 None -7 44 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00408 9127 53 None -7 44 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
2803 7742 58 None -1 19 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1038/s41467-023-40064-9
516 7742 58 None -1 19 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1038/s41467-023-40064-9
704 7742 58 None -1 19 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1038/s41467-023-40064-9
CHEMBL134 7742 58 None -1 19 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1038/s41467-023-40064-9
DB00575 7742 58 None -1 19 Human 6.9 pAC50 = 6.9 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1038/s41467-023-40064-9
9429 208912 58 None - 4 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 6 0 6 3.2 CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1 10.1038/s41467-023-40064-9
CHEMBL609109 208912 58 None - 4 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 6 0 6 3.2 CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1 10.1038/s41467-023-40064-9
179 7188 115 None - 50 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1038/s41467-023-40064-9
2159 7188 115 None - 50 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1038/s41467-023-40064-9
963 7188 115 None - 50 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1038/s41467-023-40064-9
CHEMBL243712 7188 115 None - 50 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1038/s41467-023-40064-9
DB06288 7188 115 None - 50 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC 10.1038/s41467-023-40064-9
8249 66179 65 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 205 3 5 2 0.2 N=C(N)NC(=N)NCCc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1528839 66179 65 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 205 3 5 2 0.2 N=C(N)NC(=N)NCCc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL170988 66179 65 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 205 3 5 2 0.2 N=C(N)NC(=N)NCCc1ccccc1 10.1038/s41467-023-40064-9
2448 106099 70 None - 18 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 6 1 3 4.5 O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1 10.1038/s41467-023-40064-9
CHEMBL28218 106099 70 None - 18 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 6 1 3 4.5 O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1 10.1038/s41467-023-40064-9
3191 109635 97 None -9 25 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
CHEMBL305660 109635 97 None -9 25 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
4746 211670 31 None - 4 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL1334033 211670 31 None - 4 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL75880 211670 31 None - 4 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
1201549 7384 24 None -13 20 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
333 7384 24 None -13 20 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
7601 7384 24 None -13 20 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201203 7384 24 None -13 20 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL438151 7384 24 None -13 20 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
DB00245 7384 24 None -13 20 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
4066 211405 78 None - 7 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 322 2 0 3 4.6 c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 10.1038/s41467-023-40064-9
CHEMBL73451 211405 78 None - 7 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 322 2 0 3 4.6 c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 10.1038/s41467-023-40064-9
23480 130868 23 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 5 1 1 5.0 CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL363295 130868 23 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 5 1 1 5.0 CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C 10.1038/s41467-023-40064-9
135 9310 43 None -8 56 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1038/s41467-023-40064-9
1796 9310 43 None -8 56 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1038/s41467-023-40064-9
4184 9310 43 None -8 56 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1038/s41467-023-40064-9
CHEMBL6437 9310 43 None -8 56 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1038/s41467-023-40064-9
DB06148 9310 43 None -8 56 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 10.1038/s41467-023-40064-9
2398 7741 62 None -2 29 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2801 7741 62 None -2 29 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
701 7741 62 None -2 29 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL415 7741 62 None -2 29 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB01242 7741 62 None -2 29 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2136 9869 30 None -3 6 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
4768 9869 30 None -3 6 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
7268 9869 30 None -3 6 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL753 9869 30 None -3 6 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
DB00925 9869 30 None -3 6 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
100 10577 58 None -35 54 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
2637 10577 58 None -35 54 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
5452 10577 58 None -35 54 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
CHEMBL479 10577 58 None -35 54 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
DB00679 10577 58 None -35 54 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
2472 74058 48 None - 0 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 5 1 7 2.1 CCCC(=O)N1CCCN(c2nc(N)c3cc(OC)c(OC)cc3n2)CC1 10.1038/s41467-023-40064-9
CHEMBL188185 74058 48 None - 0 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 5 1 7 2.1 CCCC(=O)N1CCCN(c2nc(N)c3cc(OC)c(OC)cc3n2)CC1 10.1038/s41467-023-40064-9
9801 98360 35 None - 0 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 329 8 1 1 5.4 CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL24072 98360 35 None - 0 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 329 8 1 1 5.4 CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
138402398 34907 56 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 3 3 5 1.6 NS(=O)(=O)c1cc2c(cc1Cl)NC(CC1CCCC1)NS2(=O)=O 10.1038/s41467-023-40064-9
2904 34907 56 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 3 3 5 1.6 NS(=O)(=O)c1cc2c(cc1Cl)NC(CC1CCCC1)NS2(=O)=O 10.1038/s41467-023-40064-9
CHEMBL1373254 34907 56 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 3 3 5 1.6 NS(=O)(=O)c1cc2c(cc1Cl)NC(CC1CCCC1)NS2(=O)=O 10.1038/s41467-023-40064-9
56959 38330 103 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 427 9 2 6 2.3 COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1 10.1038/s41467-023-40064-9
CHEMBL1404 38330 103 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 427 9 2 6 2.3 COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1 10.1038/s41467-023-40064-9
CHEMBL1526084 38330 103 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 427 9 2 6 2.3 COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1 10.1038/s41467-023-40064-9
5573 74355 92 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 9 0 6 3.7 CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C 10.1038/s41467-023-40064-9
CHEMBL1325297 74355 92 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 9 0 6 3.7 CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C 10.1038/s41467-023-40064-9
CHEMBL190044 74355 92 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 9 0 6 3.7 CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C 10.1038/s41467-023-40064-9
CHEMBL3039583 217728 0 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O 10.1038/s41467-023-40064-9
1836 9370 59 None - 15 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
3340 9370 59 None - 15 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
5281040 9370 59 None - 15 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
CHEMBL787 9370 59 None - 15 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
DB00471 9370 59 None - 15 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
42890 16197 59 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 497 3 5 10 1.0 CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O 10.1038/s41467-023-40064-9
CHEMBL1117 16197 59 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 497 3 5 10 1.0 CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O 10.1038/s41467-023-40064-9
2780 117306 36 None - 10 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 5 2 4 3.3 COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL325109 117306 36 None - 10 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 5 2 4 3.3 COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
60753 201463 40 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 384 14 2 4 4.2 CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1 10.1038/s41467-023-40064-9
CHEMBL533 201463 40 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 384 14 2 4 4.2 CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1 10.1038/s41467-023-40064-9
168871 95905 14 None - 0 Human 7.8 pAC50 = 7.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 563 4 3 6 2.1 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 10.1038/s41467-023-40064-9
CHEMBL2365712 95905 14 None - 0 Human 7.8 pAC50 = 7.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 563 4 3 6 2.1 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 10.1038/s41467-023-40064-9
2585 7590 103 None -29 22 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 7590 103 None -29 22 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 7590 103 None -29 22 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 7590 103 None -29 22 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 7590 103 None -29 22 Human 6.8 pAC50 = 6.8 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
2662 18156 131 None -1 30 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 10.1038/s41467-023-40064-9
CHEMBL118 18156 131 None -1 30 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 10.1038/s41467-023-40064-9
12574 9383 88 None -3890 6 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 10.1038/s41467-023-40064-9
4810 9383 88 None -3890 6 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 10.1038/s41467-023-40064-9
CHEMBL19236 9383 88 None -3890 6 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 10.1038/s41467-023-40064-9
DB09242 9383 88 None -3890 6 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 10.1038/s41467-023-40064-9
24826799 17570 104 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
CHEMBL1171837 17570 104 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
47472 26209 57 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 7 0 3 6.6 Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1295 26209 57 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 7 0 3 6.6 Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 10.1038/s41467-023-40064-9
3949 107390 50 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 468 8 0 5 4.9 COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC 10.1038/s41467-023-40064-9
CHEMBL29188 107390 50 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 468 8 0 5 4.9 COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC 10.1038/s41467-023-40064-9
55483 211876 40 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 13 4 4 3.6 Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O 10.1038/s41467-023-40064-9
CHEMBL77622 211876 40 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 13 4 4 3.6 Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O 10.1038/s41467-023-40064-9
2564 212963 51 None - 3 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 290 6 0 3 3.4 CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1 10.1038/s41467-023-40064-9
CHEMBL864 212963 51 None - 3 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 290 6 0 3 3.4 CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1 10.1038/s41467-023-40064-9
119607 212982 113 None -97 27 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 10.1038/s41467-023-40064-9
CHEMBL865 212982 113 None -97 27 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 10.1038/s41467-023-40064-9
11079 9510 63 None -3 5 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1038/s41467-023-40064-9
3369 9510 63 None -3 5 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1038/s41467-023-40064-9
4436 9510 63 None -3 5 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1038/s41467-023-40064-9
5509 9510 63 None -3 5 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL761 9510 63 None -3 5 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1038/s41467-023-40064-9
DB06711 9510 63 None -3 5 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1038/s41467-023-40064-9
129211 10521 78 None - 16 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
2562 10521 78 None - 16 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
488 10521 78 None - 16 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
CHEMBL836 10521 78 None - 16 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
DB00706 10521 78 None - 16 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
3394 203214 120 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 3 1 1 3.7 CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1 10.1038/s41467-023-40064-9
CHEMBL563 203214 120 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 3 1 1 3.7 CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1 10.1038/s41467-023-40064-9
16362 9899 71 None -363 29 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2172 9899 71 None -363 29 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
90 9899 71 None -363 29 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1423 9899 71 None -363 29 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01100 9899 71 None -363 29 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2435 10362 83 None -104 48 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
60149 10362 83 None -104 48 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
98 10362 83 None -104 48 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
CHEMBL12713 10362 83 None -104 48 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
DB06144 10362 83 None -104 48 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
176 7186 66 None -4 31 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2157 7186 66 None -4 31 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2566 7186 66 None -4 31 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
CHEMBL633 7186 66 None -4 31 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
DB01118 7186 66 None -4 31 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
29566 84979 82 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 2 6 -2.7 O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1 10.1038/s41467-023-40064-9
CHEMBL2105420 84979 82 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 2 6 -2.7 O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1 10.1038/s41467-023-40064-9
3658 10879 53 None -114 8 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
517 10879 53 None -114 8 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
5709 10879 53 None -114 8 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL312448 10879 53 None -114 8 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
DB06694 10879 53 None -114 8 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
3158 63041 27 None -218 20 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1628227 63041 27 None -218 20 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 10.1038/s41467-023-40064-9
68602 211905 80 None -3 8 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C 10.1038/s41467-023-40064-9
CHEMBL77921 211905 80 None -3 8 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C 10.1038/s41467-023-40064-9
26879 44068 63 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 204 1 0 3 2.1 c1ccc([C@H]2CN3CCSC3=N2)cc1 10.1038/s41467-023-40064-9
CHEMBL1454 44068 63 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 204 1 0 3 2.1 c1ccc([C@H]2CN3CCSC3=N2)cc1 10.1038/s41467-023-40064-9
65709 66655 39 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 365 8 0 5 3.3 CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1729803 66655 39 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 365 8 0 5 3.3 CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21 10.1038/s41467-023-40064-9
1343 8670 62 None -91 9 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 10.1038/s41467-023-40064-9
3519 8670 62 None -91 9 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 10.1038/s41467-023-40064-9
522 8670 62 None -91 9 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 10.1038/s41467-023-40064-9
CHEMBL862 8670 62 None -91 9 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 10.1038/s41467-023-40064-9
DB01018 8670 62 None -91 9 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 10.1038/s41467-023-40064-9
20628 103323 28 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 324 6 1 5 3.7 CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12 10.1038/s41467-023-40064-9
CHEMBL26291 103323 28 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 324 6 1 5 3.7 CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12 10.1038/s41467-023-40064-9
2318 161635 29 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 351 7 1 3 4.1 CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL400599 161635 29 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 351 7 1 3 4.1 CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1 10.1038/s41467-023-40064-9
2995 211184 53 None - 23 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1696 211184 53 None - 23 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL72 211184 53 None - 23 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 10.1038/s41467-023-40064-9
2470 10425 50 None - 58 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3300 10425 50 None - 58 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
5265 10425 50 None - 58 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
99 10425 50 None - 58 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL267930 10425 50 None - 58 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
213046 9164 59 None - 9 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
4168 9164 59 None - 9 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
7461 9164 59 None - 9 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
CHEMBL1237021 9164 59 None - 9 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
DB08815 9164 59 None - 9 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
3698 25701 92 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 187 1 2 3 1.0 Nc1cc(-c2ccncc2)c[nH]c1=O 10.1038/s41467-023-40064-9
CHEMBL12856 25701 92 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 187 1 2 3 1.0 Nc1cc(-c2ccncc2)c[nH]c1=O 10.1038/s41467-023-40064-9
104850 10103 96 None - 6 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
4150 10103 96 None - 6 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
743 10103 96 None - 6 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL111 10103 96 None - 6 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
DB06155 10103 96 None - 6 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
54841 209906 52 None - 30 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL641 209906 52 None - 30 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 10.1038/s41467-023-40064-9
2105 9828 37 None -8 32 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 10.1038/s41467-023-40064-9
47811 9828 37 None -8 32 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 10.1038/s41467-023-40064-9
48 9828 37 None -8 32 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 10.1038/s41467-023-40064-9
CHEMBL531 9828 37 None -8 32 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 10.1038/s41467-023-40064-9
DB01186 9828 37 None -8 32 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 10.1038/s41467-023-40064-9
443955 211149 92 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 350 3 0 4 4.1 CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32 10.1038/s41467-023-40064-9
CHEMBL71752 211149 92 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 350 3 0 4 4.1 CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32 10.1038/s41467-023-40064-9
2713 212050 82 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5353524 212050 82 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5360566 212050 82 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
88536661 212050 82 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
9552079 212050 82 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1330113 212050 82 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL790 212050 82 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
4640 85041 30 None - 0 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 6 1 4 3.9 COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC 10.1038/s41467-023-40064-9
CHEMBL2107011 85041 30 None - 0 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 6 1 4 3.9 COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC 10.1038/s41467-023-40064-9
37 7565 60 None -9 17 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 10.1038/s41467-023-40064-9
460 7565 60 None -9 17 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 10.1038/s41467-023-40064-9
54746 7565 60 None -9 17 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 10.1038/s41467-023-40064-9
CHEMBL1201087 7565 60 None -9 17 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 10.1038/s41467-023-40064-9
DB00248 7565 60 None -9 17 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 10.1038/s41467-023-40064-9
24965990 10486 59 None - 5 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 3 0 7 4.1 Cc1ccc(c(c1)C(=O)N1CCN(CC[C@H]1C)c1oc2c(n1)cc(cc2)Cl)n1nccn1 10.1038/s41467-023-40064-9
2890 10486 59 None - 5 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 3 0 7 4.1 Cc1ccc(c(c1)C(=O)N1CCN(CC[C@H]1C)c1oc2c(n1)cc(cc2)Cl)n1nccn1 10.1038/s41467-023-40064-9
4881 10486 59 None - 5 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 3 0 7 4.1 Cc1ccc(c(c1)C(=O)N1CCN(CC[C@H]1C)c1oc2c(n1)cc(cc2)Cl)n1nccn1 10.1038/s41467-023-40064-9
CHEMBL1083659 10486 59 None - 5 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 3 0 7 4.1 Cc1ccc(c(c1)C(=O)N1CCN(CC[C@H]1C)c1oc2c(n1)cc(cc2)Cl)n1nccn1 10.1038/s41467-023-40064-9
DB09034 10486 59 None - 5 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 3 0 7 4.1 Cc1ccc(c(c1)C(=O)N1CCN(CC[C@H]1C)c1oc2c(n1)cc(cc2)Cl)n1nccn1 10.1038/s41467-023-40064-9
131411 22164 70 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 476 7 1 6 5.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12 10.1038/s41467-023-40064-9
28446253 22164 70 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 476 7 1 6 5.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12 10.1038/s41467-023-40064-9
CHEMBL1214598 22164 70 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 476 7 1 6 5.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12 10.1038/s41467-023-40064-9
2473 169962 47 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 248 5 2 4 1.7 CC(C)(C)NCC(O)COc1ccccc1C#N 10.1038/s41467-023-40064-9
CHEMBL418134 169962 47 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 248 5 2 4 1.7 CC(C)(C)NCC(O)COc1ccccc1C#N 10.1038/s41467-023-40064-9
4452 9538 19 None - 18 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
983 9538 19 None - 18 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
CHEMBL20734 9538 19 None - 18 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
1547484 7727 74 None -12 20 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
654 7727 74 None -12 20 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
9072 7727 74 None -12 20 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL43064 7727 74 None -12 20 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
DB00568 7727 74 None -12 20 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
54454 12030 88 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
CHEMBL1064 12030 88 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
228 7233 28 None -3 23 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
33 7233 28 None -3 23 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
6005 7233 28 None -3 23 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
CHEMBL53 7233 28 None -3 23 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
DB00714 7233 28 None -3 23 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
180 7189 56 None -7 40 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
200 7189 56 None -7 40 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
2160 7189 56 None -7 40 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL629 7189 56 None -7 40 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00321 7189 56 None -7 40 Human 6.6 pAC50 = 6.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
5311017 127382 11 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 239 5 0 1 3.8 C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL3545985 127382 11 None - 0 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 239 5 0 1 3.8 C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1 10.1038/s41467-023-40064-9
2333 149113 97 None - 2 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
CHEMBL388590 149113 97 None - 2 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
72093 41835 9 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 41835 9 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 41835 9 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
68617 212306 62 None -3 26 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1709 212306 62 None -3 26 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL809 212306 62 None -3 26 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
25181577 84994 56 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 574 9 2 9 5.0 CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 10.1038/s41467-023-40064-9
CHEMBL2105695 84994 56 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 574 9 2 9 5.0 CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 10.1038/s41467-023-40064-9
65700 85035 28 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 238 1 1 2 3.3 CNC1Cc2ccccc2N(C)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL2106919 85035 28 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 238 1 1 2 3.3 CNC1Cc2ccccc2N(C)c2ccccc21 10.1038/s41467-023-40064-9
4031 106089 28 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 429 13 0 6 4.6 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1 10.1038/s41467-023-40064-9
CHEMBL282121 106089 28 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 429 13 0 6 4.6 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1 10.1038/s41467-023-40064-9
5591 164310 90 None - 2 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
CHEMBL408 164310 90 None - 2 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
2683 10606 60 None -20 4 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 10.1038/s41467-023-40064-9
5487 10606 60 None -20 4 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 10.1038/s41467-023-40064-9
7308 10606 60 None -20 4 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 10.1038/s41467-023-40064-9
CHEMBL1079 10606 60 None -20 4 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 10.1038/s41467-023-40064-9
DB00697 10606 60 None -20 4 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 10.1038/s41467-023-40064-9
123606 7140 70 None - 3 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C 10.1038/s41467-023-40064-9
128 7140 70 None - 3 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C 10.1038/s41467-023-40064-9
7110 7140 70 None - 3 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C 10.1038/s41467-023-40064-9
CHEMBL1505 7140 70 None - 3 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C 10.1038/s41467-023-40064-9
DB00918 7140 70 None - 3 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C 10.1038/s41467-023-40064-9
54697325 65753 35 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 556 6 6 10 1.3 CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O 10.1038/s41467-023-40064-9
CHEMBL1689772 65753 35 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 556 6 6 10 1.3 CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O 10.1038/s41467-023-40064-9
4418 40996 85 None - 7 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1038/s41467-023-40064-9
CHEMBL142635 40996 85 None - 7 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1038/s41467-023-40064-9
4260 59332 31 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 279 6 0 4 3.0 CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C 10.1038/s41467-023-40064-9
CHEMBL159226 59332 31 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 279 6 0 4 3.0 CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C 10.1038/s41467-023-40064-9
1427 8794 54 None - 27 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
357 8794 54 None - 27 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
3696 8794 54 None - 27 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL11 8794 54 None - 27 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00458 8794 54 None - 27 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
4940 21242 35 None - 0 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 340 5 0 4 4.8 CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1201210 21242 35 None - 0 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 340 5 0 4 4.8 CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2 10.1038/s41467-023-40064-9
5311507 201594 41 None - 1 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 400 5 1 4 4.2 OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1 10.1038/s41467-023-40064-9
CHEMBL53904 201594 41 None - 1 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 400 5 1 4 4.2 OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1 10.1038/s41467-023-40064-9
4756 23421 50 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 213 2 2 5 2.7 Nc1ccc(/N=N/c2ccccc2)c(N)n1 10.1038/s41467-023-40064-9
CHEMBL1201022 23421 50 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 213 2 2 5 2.7 Nc1ccc(/N=N/c2ccccc2)c(N)n1 10.1038/s41467-023-40064-9
CHEMBL1242 23421 50 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 213 2 2 5 2.7 Nc1ccc(/N=N/c2ccccc2)c(N)n1 10.1038/s41467-023-40064-9
47979 84985 59 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 8 2 6 0.7 C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC 10.1038/s41467-023-40064-9
CHEMBL2105581 84985 59 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 8 2 6 0.7 C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC 10.1038/s41467-023-40064-9
154257 185398 67 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 470 7 2 5 6.3 Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 10.1038/s41467-023-40064-9
CHEMBL46740 185398 67 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 470 7 2 5 6.3 Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 10.1038/s41467-023-40064-9
4209 9937 75 None -131 33 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
4893 9937 75 None -131 33 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
503 9937 75 None -131 33 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
5385 9937 75 None -131 33 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
CHEMBL2 9937 75 None -131 33 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
DB00457 9937 75 None -131 33 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
135409453 10545 41 None - 2 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 10545 41 None - 2 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 10545 41 None - 2 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
242 7258 124 None -64 51 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 7258 124 None -64 51 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 7258 124 None -64 51 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 7258 124 None -64 51 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 7258 124 None -64 51 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
1890 9535 49 None -1 16 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
4449 9535 49 None -1 16 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
7247 9535 49 None -1 16 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
CHEMBL623 9535 49 None -1 16 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
DB01149 9535 49 None -1 16 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
108000 63627 39 None - 0 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 279 2 1 3 2.9 Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21 10.1038/s41467-023-40064-9
135418340 63627 39 None - 0 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 279 2 1 3 2.9 Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1643895 63627 39 None - 0 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 279 2 1 3 2.9 Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21 10.1038/s41467-023-40064-9
213 10625 55 None -3 43 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
2717 10625 55 None -3 43 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
5533 10625 55 None -3 43 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
CHEMBL621 10625 55 None -3 43 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
DB00656 10625 55 None -3 43 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
150 9287 21 None -27 16 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
1764 9287 21 None -27 16 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
8226 9287 21 None -27 16 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
CHEMBL1201356 9287 21 None -27 16 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
DB00353 9287 21 None -27 16 Human 6.5 pAC50 = 6.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
5453 210398 102 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 189 3 0 1 0.2 S=P(N1CC1)(N1CC1)N1CC1 10.1038/s41467-023-40064-9
CHEMBL671 210398 102 None - 0 Human 5.5 pAC50 = 5.5 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 189 3 0 1 0.2 S=P(N1CC1)(N1CC1)N1CC1 10.1038/s41467-023-40064-9
3236 74383 43 None -1 2 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 5 0 2 3.6 CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL1902981 74383 43 None -1 2 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 5 0 2 3.6 CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1 10.1038/s41467-023-40064-9
1212 8443 50 None -38 65 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
204 8443 50 None -38 65 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
3372 8443 50 None -38 65 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL726 8443 50 None -38 65 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
DB00623 8443 50 None -38 65 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
10531 8202 21 None -10 24 Human 7.4 pAC50 = 7.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
121 8202 21 None -10 24 Human 7.4 pAC50 = 7.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
888 8202 21 None -10 24 Human 7.4 pAC50 = 7.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
CHEMBL1732 8202 21 None -10 24 Human 7.4 pAC50 = 7.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
DB00320 8202 21 None -10 24 Human 7.4 pAC50 = 7.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
2267 7347 71 None - 7 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
271 7347 71 None - 7 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
7121 7347 71 None - 7 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
CHEMBL639 7347 71 None - 7 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
DB00972 7347 71 None - 7 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
3149 19386 15 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1187011 19386 15 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
4846 34760 53 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 1 2 6 2.2 O=C(O)c1cc(O)c2c3nc4ccccc4oc-3cc(=O)c2n1 10.1038/s41467-023-40064-9
CHEMBL1372341 34760 53 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 1 2 6 2.2 O=C(O)c1cc(O)c2c3nc4ccccc4oc-3cc(=O)c2n1 10.1038/s41467-023-40064-9
2726 7706 68 None -8 72 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
621 7706 68 None -8 72 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
83 7706 68 None -8 72 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL71 7706 68 None -8 72 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB00477 7706 68 None -8 72 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
1209 8439 75 None -12 32 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
203 8439 75 None -12 32 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
3386 8439 75 None -12 32 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL41 8439 75 None -12 32 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
DB00472 8439 75 None -12 32 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
1043 8363 14 None -19 29 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
149 8363 14 None -19 29 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
8223 8363 14 None -19 29 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
CHEMBL442 8363 14 None -19 29 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
DB00696 8363 14 None -19 29 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
202 8290 77 None - 33 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
60835 8290 77 None - 33 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
972 8290 77 None - 33 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1175 8290 77 None - 33 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
DB00476 8290 77 None - 33 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
3584 10549 64 None -21 14 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1038/s41467-023-40064-9
5401 10549 64 None -21 14 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1038/s41467-023-40064-9
7302 10549 64 None -21 14 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1038/s41467-023-40064-9
CHEMBL611 10549 64 None -21 14 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1038/s41467-023-40064-9
DB01162 10549 64 None -21 14 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1038/s41467-023-40064-9
1028 7079 71 None -128 30 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
139148732 7079 71 None -128 30 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
479 7079 71 None -128 30 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
5816 7079 71 None -128 30 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
CHEMBL679 7079 71 None -128 30 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
DB00668 7079 71 None -128 30 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
3947 213174 53 None - 16 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 7 0 3 5.8 CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL87708 213174 53 None - 16 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 7 0 3 5.8 CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1 10.1038/s41467-023-40064-9
1971 9641 38 None -3 30 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
2404 9641 38 None -3 30 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
4543 9641 38 None -3 30 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL445 9641 38 None -3 30 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
DB00540 9641 38 None -3 30 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
2435 7509 100 None -36 12 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1038/s41467-023-40064-9
395 7509 100 None -36 12 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1038/s41467-023-40064-9
520 7509 100 None -36 12 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1038/s41467-023-40064-9
5386 7509 100 None -36 12 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1038/s41467-023-40064-9
CHEMBL844 7509 100 None -36 12 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1038/s41467-023-40064-9
DB00484 7509 100 None -36 12 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1038/s41467-023-40064-9
1228 10638 34 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 4 0 2 3.9 Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 10.1038/s41467-023-40064-9
2763 10638 34 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 4 0 2 3.9 Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 10.1038/s41467-023-40064-9
5282443 10638 34 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 4 0 2 3.9 Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 10.1038/s41467-023-40064-9
CHEMBL855 10638 34 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 4 0 2 3.9 Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 10.1038/s41467-023-40064-9
DB00427 10638 34 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 4 0 2 3.9 Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 10.1038/s41467-023-40064-9
5210 40112 48 None 123 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 10.1038/s41467-023-40064-9
CHEMBL1200765 40112 48 None 123 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 10.1038/s41467-023-40064-9
CHEMBL1419 40112 48 None 123 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 10.1038/s41467-023-40064-9
5329102 201505 86 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 201505 86 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
3689 109548 55 None - 0 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 325 5 2 3 3.8 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL1372983 109548 55 None - 0 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 325 5 2 3 3.8 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL305187 109548 55 None - 0 Human 6.4 pAC50 = 6.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 325 5 2 3 3.8 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
118422671 9533 65 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
1887 9533 65 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
71301 9533 65 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
7246 9533 65 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL434394 9533 65 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
DB04861 9533 65 None - 4 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
16960 21259 23 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 5 0 2 3.9 CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1 10.1038/s41467-023-40064-9
CHEMBL1201287 21259 23 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 5 0 2 3.9 CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1 10.1038/s41467-023-40064-9
2337 10030 77 None -12 62 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
50 10030 77 None -12 62 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
5002 10030 77 None -12 62 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL716 10030 77 None -12 62 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
DB01224 10030 77 None -12 62 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
135398737 7745 93 None -9 90 Human 7.3 pAC50 = 7.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
38 7745 93 None -9 90 Human 7.3 pAC50 = 7.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
722 7745 93 None -9 90 Human 7.3 pAC50 = 7.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL42 7745 93 None -9 90 Human 7.3 pAC50 = 7.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
DB00363 7745 93 None -9 90 Human 7.3 pAC50 = 7.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
6436173 61890 45 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1617 61890 45 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
1210 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
1213 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
2725 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
33036 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
4411 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
616 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
6976 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
716121 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL1201353 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL1554789 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL505 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
DB01114 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
DB13679 7705 51 None -234 21 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
2601 10552 33 None -1 21 Human 8.3 pAC50 = 8.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
443951 10552 33 None -1 21 Human 8.3 pAC50 = 8.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
56 10552 33 None -1 21 Human 8.3 pAC50 = 8.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
CHEMBL73151 10552 33 None -1 21 Human 8.3 pAC50 = 8.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
DB13399 10552 33 None -1 21 Human 8.3 pAC50 = 8.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
21772 85174 31 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 293 4 0 1 4.5 CC(CC1c2ccccc2CCc2ccccc21)CN(C)C 10.1038/s41467-023-40064-9
CHEMBL2110816 85174 31 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 293 4 0 1 4.5 CC(CC1c2ccccc2CCc2ccccc21)CN(C)C 10.1038/s41467-023-40064-9
2220 9908 82 None - 14 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1038/s41467-023-40064-9
27400 9908 82 None - 14 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1038/s41467-023-40064-9
93 9908 82 None - 14 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1038/s41467-023-40064-9
CHEMBL294951 9908 82 None - 14 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1038/s41467-023-40064-9
DB06153 9908 82 None - 14 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1038/s41467-023-40064-9
1164 8411 26 None - 12 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 336 6 0 2 4.1 CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 10.1038/s41467-023-40064-9
1626 8411 26 None - 12 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 336 6 0 2 4.1 CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 10.1038/s41467-023-40064-9
3345 8411 26 None - 12 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 336 6 0 2 4.1 CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL596 8411 26 None - 12 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 336 6 0 2 4.1 CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 10.1038/s41467-023-40064-9
DB00813 8411 26 None - 12 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 336 6 0 2 4.1 CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 10.1038/s41467-023-40064-9
3157 8252 71 None - 12 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
7170 8252 71 None - 12 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
954 8252 71 None - 12 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
CHEMBL707 8252 71 None - 12 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
DB00590 8252 71 None - 12 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
17676 13844 29 None - 3 Human 7.3 pAC50 = 7.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 411 7 1 6 3.5 CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
5281082 13844 29 None - 3 Human 7.3 pAC50 = 7.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 411 7 1 6 3.5 CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1085 13844 29 None - 3 Human 7.3 pAC50 = 7.3 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 411 7 1 6 3.5 CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
11658860 9123 51 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
2941 9123 51 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
4374 9123 51 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
CHEMBL360328 9123 51 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
DB04871 9123 51 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
103 10925 61 None -5 53 Human 7.2 pAC50 = 7.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2875 10925 61 None -5 53 Human 7.2 pAC50 = 7.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
5736 10925 61 None -5 53 Human 7.2 pAC50 = 7.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL285802 10925 61 None -5 53 Human 7.2 pAC50 = 7.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB09225 10925 61 None -5 53 Human 7.2 pAC50 = 7.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2351 10059 64 None -15 21 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
2820 10059 64 None -15 21 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
5035 10059 64 None -15 21 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
CHEMBL81 10059 64 None -15 21 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
DB00481 10059 64 None -15 21 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
2351 11072 49 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1008 11072 49 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1257078 11072 49 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
36811 8236 37 None -4 7 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
535 8236 37 None -4 7 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
937 8236 37 None -4 7 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
CHEMBL926 8236 37 None -4 7 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
DB00841 8236 37 None -4 7 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
1222 8445 49 None -30 32 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3396 8445 49 None -30 32 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
85 8445 49 None -30 32 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL46516 8445 49 None -30 32 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
DB04842 8445 49 None -30 32 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
134 9292 24 None -93 67 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 10.1038/s41467-023-40064-9
1775 9292 24 None -93 67 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 10.1038/s41467-023-40064-9
9681 9292 24 None -93 67 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 10.1038/s41467-023-40064-9
CHEMBL1065 9292 24 None -93 67 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 10.1038/s41467-023-40064-9
DB00247 9292 24 None -93 67 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 10.1038/s41467-023-40064-9
4976 210358 29 None - 12 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 4 1 1 4.3 CNCCCC1c2ccccc2C=Cc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL668 210358 29 None - 12 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 4 1 1 4.3 CNCCCC1c2ccccc2C=Cc2ccccc21 10.1038/s41467-023-40064-9
2865 10915 73 None -38 53 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
59 10915 73 None -38 53 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
60854 10915 73 None -38 53 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL708 10915 73 None -38 53 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
DB00246 10915 73 None -38 53 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
441074 26186 82 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 324 4 1 4 3.2 C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12 10.1038/s41467-023-40064-9
CHEMBL1294 26186 82 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 324 4 1 4 3.2 C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12 10.1038/s41467-023-40064-9
19675 58444 43 None - 0 Human 7.2 pAC50 = 7.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 7 1 5 5.0 CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1584 58444 43 None - 0 Human 7.2 pAC50 = 7.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 7 1 5 5.0 CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
3081361 100709 123 None - 0 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 474 5 1 5 4.4 COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 10.1038/s41467-023-40064-9
CHEMBL24828 100709 123 None - 0 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 474 5 1 5 4.4 COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 10.1038/s41467-023-40064-9
2402 10143 62 None -3 24 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1038/s41467-023-40064-9
5095 10143 62 None -3 24 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1038/s41467-023-40064-9
7295 10143 62 None -3 24 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1038/s41467-023-40064-9
CHEMBL589 10143 62 None -3 24 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1038/s41467-023-40064-9
DB00268 10143 62 None -3 24 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1038/s41467-023-40064-9
2274 9947 58 None -3 31 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
4917 9947 58 None -3 31 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
7279 9947 58 None -3 31 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL728 9947 58 None -3 31 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00433 9947 58 None -3 31 Human 6.2 pAC50 = 6.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
135564886 21265 5 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
135673376 21265 5 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
137157436 21265 5 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
145948239 21265 5 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
71587099 21265 5 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
CHEMBL1201304 21265 5 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
2169 51621 35 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 380 9 3 6 1.4 COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1 10.1038/s41467-023-40064-9
CHEMBL152231 51621 35 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 380 9 3 6 1.4 COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1 10.1038/s41467-023-40064-9
1224 8214 83 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
3100 8214 83 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
8980 8214 83 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
916 8214 83 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
CHEMBL657 8214 83 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
DB01075 8214 83 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
1353 8692 93 None -85 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559 8692 93 None -85 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
86 8692 93 None -85 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
CHEMBL54 8692 93 None -85 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
DB00502 8692 93 None -85 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
319 8106 44 None - 9 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1038/s41467-023-40064-9
321 8106 44 None - 9 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1038/s41467-023-40064-9
444031 8106 44 None - 9 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1038/s41467-023-40064-9
784 8106 44 None - 9 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1038/s41467-023-40064-9
CHEMBL1346 8106 44 None - 9 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1038/s41467-023-40064-9
DB00496 8106 44 None - 9 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 3 4.0 NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2 10.1038/s41467-023-40064-9
4567 16720 34 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 299 7 3 3 3.4 CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL114655 16720 34 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 299 7 3 3 3.4 CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1 10.1038/s41467-023-40064-9
1593 9119 66 None -6 4 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
30668 9119 66 None -6 4 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
9868 9119 66 None -6 4 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
CHEMBL17860 9119 66 None -6 4 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
DB04948 9119 66 None -6 4 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
2343 21226 57 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 431 5 2 6 2.2 NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O 10.1038/s41467-023-40064-9
CHEMBL1201039 21226 57 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 431 5 2 6 2.2 NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O 10.1038/s41467-023-40064-9
68712 107114 60 None 1 5 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 10.1038/s41467-023-40064-9
CHEMBL289480 107114 60 None 1 5 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 10.1038/s41467-023-40064-9
1549120 203265 85 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56337 203265 85 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
4450 185007 69 None - 3 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 253 1 0 2 3.2 CN1CCOC(c2ccccc2)c2ccccc2C1 10.1038/s41467-023-40064-9
CHEMBL465026 185007 69 None - 3 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 253 1 0 2 3.2 CN1CCOC(c2ccccc2)c2ccccc2C1 10.1038/s41467-023-40064-9
3926 214020 40 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL92870 214020 40 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
31101 7516 40 None -33 35 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
35 7516 40 None -33 35 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
403 7516 40 None -33 35 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
CHEMBL493 7516 40 None -33 35 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
DB01200 7516 40 None -33 35 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
1028 7079 71 None -128 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
139148732 7079 71 None -128 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
479 7079 71 None -128 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
5816 7079 71 None -128 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
CHEMBL679 7079 71 None -128 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
DB00668 7079 71 None -128 30 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
2695 10613 81 None -69 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 10.1038/s41467-023-40064-9
5504 10613 81 None -69 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 10.1038/s41467-023-40064-9
7310 10613 81 None -69 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 10.1038/s41467-023-40064-9
CHEMBL770 10613 81 None -69 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 10.1038/s41467-023-40064-9
DB00797 10613 81 None -69 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 10.1038/s41467-023-40064-9
212 10578 47 None -6 25 Human 7.1 pAC50 = 7.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
2639 10578 47 None -6 25 Human 7.1 pAC50 = 7.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
941651 10578 47 None -6 25 Human 7.1 pAC50 = 7.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
CHEMBL1201 10578 47 None -6 25 Human 7.1 pAC50 = 7.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
DB01623 10578 47 None -6 25 Human 7.1 pAC50 = 7.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
1530 8963 50 None -46 21 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
3827 8963 50 None -46 21 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
7206 8963 50 None -46 21 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
CHEMBL534 8963 50 None -46 21 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
DB00920 8963 50 None -46 21 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
1400 8738 70 None - 3 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
3658 8738 70 None - 3 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
7199 8738 70 None - 3 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
91513 8738 70 None - 3 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL896 8738 70 None - 3 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
DB00557 8738 70 None - 3 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 374 8 1 4 3.1 OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 10.1038/s41467-023-40064-9
41684 37995 105 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 37995 105 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
71398 113216 44 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
CHEMBL313972 113216 44 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
260 10641 54 None - 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 1 3 3.0 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2775 10641 54 None - 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 1 3 3.0 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 10.1038/s41467-023-40064-9
656665 10641 54 None - 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 1 3 3.0 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL56564 10641 54 None - 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 1 3 3.0 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB11699 10641 54 None - 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 1 3 3.0 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 10.1038/s41467-023-40064-9
216416 118358 48 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL328190 118358 48 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
2146 9874 67 None - 9 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1038/s41467-023-40064-9
485 9874 67 None - 9 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1038/s41467-023-40064-9
6041 9874 67 None - 9 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1038/s41467-023-40064-9
CHEMBL1215 9874 67 None - 9 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1038/s41467-023-40064-9
DB00388 9874 67 None - 9 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1038/s41467-023-40064-9
21722 24764 31 None - 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 2 4.3 CN(C)CCCn1c2c(c3ccccc31)CCCCCC2 10.1038/s41467-023-40064-9
CHEMBL126224 24764 31 None - 6 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 2 4.3 CN(C)CCCn1c2c(c3ccccc31)CCCCCC2 10.1038/s41467-023-40064-9
16363 7383 53 None - 7 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
312 7383 53 None - 7 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
9215 7383 53 None - 7 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL297302 7383 53 None - 7 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB12867 7383 53 None - 7 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
3151 8244 97 None -97 26 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
945 8244 97 None -97 26 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
965 8244 97 None -97 26 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL219916 8244 97 None -97 26 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01184 8244 97 None -97 26 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
4011 89183 49 None -16 24 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 10.1038/s41467-023-40064-9
CHEMBL21731 89183 49 None -16 24 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 10.1038/s41467-023-40064-9
10184653 17769 107 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 8 2 7 4.4 CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 10.1038/s41467-023-40064-9
CHEMBL1173655 17769 107 None - 0 Human 6.1 pAC50 = 6.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 8 2 7 4.4 CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 10.1038/s41467-023-40064-9
3052776 213335 90 None - 1 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 171 2 1 1 1.9 C#CCN[C@@H]1CCc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL887 213335 90 None - 1 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 171 2 1 1 1.9 C#CCN[C@@H]1CCc2ccccc21 10.1038/s41467-023-40064-9
19910 44182 106 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 190 1 1 4 1.8 O=[N+]([O-])c1ccc(O)c2ncccc12 10.1038/s41467-023-40064-9
CHEMBL1454910 44182 106 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 190 1 1 4 1.8 O=[N+]([O-])c1ccc(O)c2ncccc12 10.1038/s41467-023-40064-9
115 7131 71 None - 7 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1038/s41467-023-40064-9
2092 7131 71 None - 7 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1038/s41467-023-40064-9
7109 7131 71 None - 7 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1038/s41467-023-40064-9
CHEMBL709 7131 71 None - 7 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1038/s41467-023-40064-9
DB00346 7131 71 None - 7 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1038/s41467-023-40064-9
7699 35067 55 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 603 32 1 12 2.8 CCCCNc1ccc(C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)cc1 10.1038/s41467-023-40064-9
CHEMBL1374379 35067 55 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 603 32 1 12 2.8 CCCCNc1ccc(C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)cc1 10.1038/s41467-023-40064-9
68867 84948 38 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 402 7 2 6 3.1 CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL2104523 84948 38 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 402 7 2 6 3.1 CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1 10.1038/s41467-023-40064-9
1830 9368 44 None -10 28 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1038/s41467-023-40064-9
207 9368 44 None -10 28 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1038/s41467-023-40064-9
23897 9368 44 None -10 28 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1038/s41467-023-40064-9
CHEMBL460 9368 44 None -10 28 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1038/s41467-023-40064-9
DB01618 9368 44 None -10 28 Human 7.0 pAC50 = 7.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1038/s41467-023-40064-9
2335 18620 22 None -2 12 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 18620 22 None -2 12 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 18620 22 None -2 12 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 18620 22 None -2 12 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
65859 25821 88 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 236 4 2 4 0.2 OC[C@@H](O)CN1CCN(c2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL1288810 25821 88 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 236 4 2 4 0.2 OC[C@@H](O)CN1CCN(c2ccccc2)CC1 10.1038/s41467-023-40064-9
214 10632 58 None -39 30 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
2740 10632 58 None -39 30 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
5566 10632 58 None -39 30 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
66064 10632 58 None -39 30 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL422 10632 58 None -39 30 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
DB00831 10632 58 None -39 30 Human 6.0 pAC50 = 6.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
1210 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
1213 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
2725 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
33036 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
4411 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
616 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
6976 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
716121 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL1201353 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL1554789 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL505 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
DB01114 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
DB13679 7705 51 None -234 21 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
5639 105671 75 None - 5 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 7 1 8 0.7 COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 10.1038/s41467-023-40064-9
CHEMBL279229 105671 75 None - 5 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 7 1 8 0.7 COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 10.1038/s41467-023-40064-9
4979271 107955 58 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 363 2 1 6 1.7 CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2SCC4)CC1 10.1038/s41467-023-40064-9
58258 107955 58 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 363 2 1 6 1.7 CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2SCC4)CC1 10.1038/s41467-023-40064-9
CHEMBL295619 107955 58 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 363 2 1 6 1.7 CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2SCC4)CC1 10.1038/s41467-023-40064-9
2765 7730 19 None -15 9 Human 6.0 pEC50 = 6 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/ml400232p
515 7730 19 None -15 9 Human 6.0 pEC50 = 6 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/ml400232p
CHEMBL13852 7730 19 None -15 9 Human 6.0 pEC50 = 6 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/ml400232p
DB09202 7730 19 None -15 9 Human 6.0 pEC50 = 6 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/ml400232p
49836301 25339 1 None -11 4 Human 6.0 pEC50 = 6 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/ml400232p
CHEMBL1276140 25339 1 None -11 4 Human 6.0 pEC50 = 6 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/ml400232p
28918670 99262 2 None -6 4 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 254 3 1 3 1.8 Brc1ccccc1OCC1=NCCN1 10.1021/ml400232p
CHEMBL2431279 99262 2 None -6 4 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 254 3 1 3 1.8 Brc1ccccc1OCC1=NCCN1 10.1021/ml400232p
57345629 77960 0 None -70 4 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 246 5 1 4 2.0 CC(Oc1ccccc1OC1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL1956197 77960 0 None -70 4 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 246 5 1 4 2.0 CC(Oc1ccccc1OC1CC1)C1=NCCN1 10.1021/ml400232p
70695474 84447 0 None -70 4 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL2089156 84447 0 None -70 4 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
72947314 99265 0 None -6 4 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 230 5 1 3 2.0 c1ccc(OCC2=NCCN2)c(CC2CC2)c1 10.1021/ml400232p
CHEMBL2431281 99265 0 None -6 4 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 230 5 1 3 2.0 c1ccc(OCC2=NCCN2)c(CC2CC2)c1 10.1021/ml400232p
44269013 37115 1 None -11 4 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 218 5 1 3 2.0 CCCc1ccccc1OCC1=NCCN1 10.1021/ml400232p
CHEMBL13917 37115 1 None -11 4 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 218 5 1 3 2.0 CCCc1ccccc1OCC1=NCCN1 10.1021/ml400232p
134156190 158144 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
ChEMBL 215 5 2 3 1.8 C=CCc1ccccc1NCC1=NCCN1 10.1021/acsmedchemlett.6b00290
CHEMBL3961335 158144 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
ChEMBL 215 5 2 3 1.8 C=CCc1ccccc1NCC1=NCCN1 10.1021/acsmedchemlett.6b00290
57345626 77955 2 None -15 4 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1 10.1021/ml400232p
CHEMBL1956192 77955 2 None -15 4 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1 10.1021/ml400232p
44549156 25342 0 None -42 4 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 230 4 1 3 2.3 CC(Oc1ccccc1C1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL1276218 25342 0 None -42 4 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 230 4 1 3 2.3 CC(Oc1ccccc1C1CC1)C1=NCCN1 10.1021/ml400232p
49836303 25344 1 None -43 4 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 230 4 1 3 2.3 C[C@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL1276220 25344 1 None -43 4 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 230 4 1 3 2.3 C[C@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/ml400232p
72947315 99264 0 None -10 4 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 232 5 1 4 1.6 c1ccc(OC2CC2)c(OCC2=NCCN2)c1 10.1021/ml400232p
CHEMBL2431280 99264 0 None -10 4 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 232 5 1 4 1.6 c1ccc(OC2CC2)c(OCC2=NCCN2)c1 10.1021/ml400232p
129928082 150972 1 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
ChEMBL 189 3 2 3 1.4 Cc1ccccc1NCC1=NCCN1 10.1021/acsmedchemlett.6b00290
CHEMBL3904276 150972 1 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
ChEMBL 189 3 2 3 1.4 Cc1ccccc1NCC1=NCCN1 10.1021/acsmedchemlett.6b00290
57345628 77958 0 None -38 4 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL1956195 77958 0 None -38 4 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
70693375 84446 0 None -8 4 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL2089155 84446 0 None -8 4 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
134137108 149505 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
ChEMBL 217 5 2 3 2.1 CCCc1ccccc1NCC1=NCCN1 10.1021/acsmedchemlett.6b00290
CHEMBL3892351 149505 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
ChEMBL 217 5 2 3 2.1 CCCc1ccccc1NCC1=NCCN1 10.1021/acsmedchemlett.6b00290
73291731 99266 0 None -38 4 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 232 5 1 3 2.4 CCCc1ccccc1OC(C)C1=NCCN1 10.1021/ml400232p
CHEMBL2431282 99266 0 None -38 4 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 232 5 1 3 2.4 CCCc1ccccc1OC(C)C1=NCCN1 10.1021/ml400232p
13123534 196232 1 None - 1 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
ChEMBL 209 3 2 3 1.8 Clc1ccccc1NCC1=NCCN1 10.1021/acsmedchemlett.6b00290
CHEMBL51358 196232 1 None - 1 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
ChEMBL 209 3 2 3 1.8 Clc1ccccc1NCC1=NCCN1 10.1021/acsmedchemlett.6b00290
44352155 123586 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
ChEMBL 251 4 2 3 2.8 c1ccc(-c2ccccc2NCC2=NCCN2)cc1 10.1021/acsmedchemlett.6b00290
CHEMBL337862 123586 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
ChEMBL 251 4 2 3 2.8 c1ccc(-c2ccccc2NCC2=NCCN2)cc1 10.1021/acsmedchemlett.6b00290
44269006 39127 1 None -10 4 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 216 5 1 3 1.8 C=CCc1ccccc1OCC1=NCCN1 10.1021/ml400232p
CHEMBL14107 39127 1 None -10 4 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human alpha2B ARAgonist activity at human alpha2B AR
ChEMBL 216 5 1 3 1.8 C=CCc1ccccc1OCC1=NCCN1 10.1021/ml400232p
1588 9105 27 None -1 44 Human 9.3 pIC50 = 9.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
28864 9105 27 None -1 44 Human 9.3 pIC50 = 9.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
43 9105 27 None -1 44 Human 9.3 pIC50 = 9.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
CHEMBL157138 9105 27 None -1 44 Human 9.3 pIC50 = 9.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
DB00589 9105 27 None -1 44 Human 9.3 pIC50 = 9.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
44377036 126934 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 393 3 0 5 4.0 Cc1nc2ccc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL351483 126934 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 393 3 0 5 4.0 Cc1nc2ccc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
44376993 63258 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 427 3 0 5 4.7 Cc1nc2c(Cl)cc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL163247 63258 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 427 3 0 5 4.7 Cc1nc2c(Cl)cc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
44377200 64194 1 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 437 3 0 5 4.1 Cc1nc2ccc(Br)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL165350 64194 1 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 437 3 0 5 4.1 Cc1nc2ccc(Br)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
44376923 63201 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 373 3 0 5 3.7 Cc1nc2cccc(C)n2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL163190 63201 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 373 3 0 5 3.7 Cc1nc2cccc(C)n2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
22120322 62695 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 373 3 0 5 3.7 Cc1ccc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2c1 10.1016/s0960-894x(99)00591-0
CHEMBL162370 62695 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 373 3 0 5 3.7 Cc1ccc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2c1 10.1016/s0960-894x(99)00591-0
6761 74574 19 None -1 18 Human 8.8 pIC50 = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 nan
CHEMBL1909072 74574 19 None -1 18 Human 8.8 pIC50 = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 nan
44376900 63042 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 375 3 1 6 3.1 Cc1nc2c(O)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL162826 63042 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 375 3 1 6 3.1 Cc1nc2c(O)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
44376927 62411 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 461 3 0 5 5.0 Cc1nc2c(Cl)cc(C(F)(F)F)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL162147 62411 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 461 3 0 5 5.0 Cc1nc2c(Cl)cc(C(F)(F)F)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
2274 9947 58 None -3 31 Human 8.0 pIC50 = 8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
4917 9947 58 None -3 31 Human 8.0 pIC50 = 8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
7279 9947 58 None -3 31 Human 8.0 pIC50 = 8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
CHEMBL728 9947 58 None -3 31 Human 8.0 pIC50 = 8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
DB00433 9947 58 None -3 31 Human 8.0 pIC50 = 8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
44376936 64248 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 373 4 0 5 3.7 Cc1nc2ccccn2c(=O)c1CCCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL165776 64248 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 373 4 0 5 3.7 Cc1nc2ccccn2c(=O)c1CCCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
2337 10030 77 None -12 62 Human 7.0 pIC50 = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
50 10030 77 None -12 62 Human 7.0 pIC50 = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
5002 10030 77 None -12 62 Human 7.0 pIC50 = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
CHEMBL716 10030 77 None -12 62 Human 7.0 pIC50 = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
DB01224 10030 77 None -12 62 Human 7.0 pIC50 = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
5511 12260 40 None - 1 Human 6.0 pIC50 = 6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 4 0 2 3.3 Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1 nan
CHEMBL1076211 12260 40 None - 1 Human 6.0 pIC50 = 6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 4 0 2 3.3 Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1 nan
59271992 124826 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of alpha-adrenoceptor 2B (unknown origin)Inhibition of alpha-adrenoceptor 2B (unknown origin)
ChEMBL 513 13 2 7 3.5 COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OC(=O)NCc2ccccc2)C(C)C)ccc1OC 10.1016/j.bmcl.2015.02.040
CHEMBL3403995 124826 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of alpha-adrenoceptor 2B (unknown origin)Inhibition of alpha-adrenoceptor 2B (unknown origin)
ChEMBL 513 13 2 7 3.5 COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OC(=O)NCc2ccccc2)C(C)C)ccc1OC 10.1016/j.bmcl.2015.02.040
2398 7741 62 None -2 29 Human 7.0 pIC50 = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
2801 7741 62 None -2 29 Human 7.0 pIC50 = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
701 7741 62 None -2 29 Human 7.0 pIC50 = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
CHEMBL415 7741 62 None -2 29 Human 7.0 pIC50 = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
DB01242 7741 62 None -2 29 Human 7.0 pIC50 = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
2435 7509 100 None -36 12 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
395 7509 100 None -36 12 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
520 7509 100 None -36 12 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
5386 7509 100 None -36 12 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
CHEMBL844 7509 100 None -36 12 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
DB00484 7509 100 None -36 12 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
9951544 64150 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 375 3 0 5 3.8 Cc1nc2ccccn2c(=O)c1CCN1CCc2sc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL165181 64150 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 375 3 0 5 3.8 Cc1nc2ccccn2c(=O)c1CCN1CCc2sc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
240 7731 43 None -11 25 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
2769 7731 43 None -11 25 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
44279790 7731 43 None -11 25 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
660 7731 43 None -11 25 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
CHEMBL1729 7731 43 None -11 25 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
CHEMBL560739 7731 43 None -11 25 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
DB00604 7731 43 None -11 25 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
3033538 8101 39 None -11 9 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
7155 8101 39 None -11 9 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
781 8101 39 None -11 9 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
CHEMBL1201216 8101 39 None -11 9 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
DB00298 8101 39 None -11 9 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
448537 167029 89 None -33 25 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 167029 89 None -33 25 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
2406 107180 89 None -10 12 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL290106 107180 89 None -10 12 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
15730 77893 80 None -2 10 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
CHEMBL195437 77893 80 None -2 10 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
11057 182928 23 None -1 20 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
3468 182928 23 None -1 20 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL459265 182928 23 None -1 20 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL64894 182928 23 None -1 20 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
124 9755 47 None -977 32 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
2032 9755 47 None -977 32 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
4636 9755 47 None -977 32 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
CHEMBL762 9755 47 None -977 32 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
DB00935 9755 47 None -977 32 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
176 7186 66 None -4 31 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 7186 66 None -4 31 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 7186 66 None -4 31 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 7186 66 None -4 31 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 7186 66 None -4 31 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2750 210840 76 None -3 12 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
CHEMBL7002 210840 76 None -3 12 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
1353 8692 93 None -85 85 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
3559 8692 93 None -85 85 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
86 8692 93 None -85 85 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
CHEMBL54 8692 93 None -85 85 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
DB00502 8692 93 None -85 85 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
3952 8669 38 None -18 12 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5353646 8669 38 None -18 12 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5443 8669 38 None -18 12 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5702063 8669 38 None -18 12 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
CHEMBL1331786 8669 38 None -18 12 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
CHEMBL420 8669 38 None -18 12 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
2662 18156 131 None -1 30 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 nan
CHEMBL118 18156 131 None -1 30 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 nan
1209 8439 75 None -12 32 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F nan
203 8439 75 None -12 32 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F nan
3386 8439 75 None -12 32 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F nan
CHEMBL41 8439 75 None -12 32 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F nan
DB00472 8439 75 None -12 32 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F nan
1548953 214458 27 None -3 17 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL954 214458 27 None -3 17 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
133 9274 52 None -14 43 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
1723 9274 52 None -14 43 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
28693 9274 52 None -14 43 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL19215 9274 52 None -14 43 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
DB13520 9274 52 None -14 43 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
8447 195728 84 None 2 13 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 332 3 0 6 5.7 c1ccc2sc(SSc3nc4ccccc4s3)nc2c1 nan
CHEMBL508112 195728 84 None 2 13 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 332 3 0 6 5.7 c1ccc2sc(SSc3nc4ccccc4s3)nc2c1 nan
102 10899 48 None -10 49 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
3659 10899 48 None -10 49 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
8969 10899 48 None -10 49 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
CHEMBL15245 10899 48 None -10 49 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
DB01392 10899 48 None -10 49 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
5029 22317 92 None -13 4 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 359 8 1 5 3.0 COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C nan
CHEMBL1219 22317 92 None -13 4 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 359 8 1 5 3.0 COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C nan
2683 109665 25 None -112 16 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL305906 109665 25 None -112 16 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL334255 109665 25 None -112 16 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
2142 9870 58 None -5 37 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
4920903 9870 58 None -5 37 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
502 9870 58 None -5 37 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
5775 9870 58 None -5 37 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
CHEMBL597 9870 58 None -5 37 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
DB00692 9870 58 None -5 37 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
2284 9956 33 None -3 29 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
4926 9956 33 None -3 29 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
7281 9956 33 None -3 29 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
CHEMBL564 9956 33 None -3 29 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
DB00420 9956 33 None -3 29 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
42574 22059 90 None -15 3 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 662 4 2 3 7.1 Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O nan
CHEMBL12131 22059 90 None -15 3 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 662 4 2 3 7.1 Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O nan
3823 56995 42 None -43 11 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
76973198 56995 42 None -43 11 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL157101 56995 42 None -43 11 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
68617 212306 62 None -3 26 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 nan
CHEMBL1709 212306 62 None -3 26 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 nan
CHEMBL809 212306 62 None -3 26 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 nan
237 211644 48 None -1 13 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL546257 211644 48 None -1 13 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL554190 211644 48 None -1 13 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL7568 211644 48 None -1 13 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL508338 195745 0 None -2 6 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL None None None None nan
12488 8438 56 None -12 23 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
941361 8438 56 None -12 23 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
CHEMBL30008 8438 56 None -12 23 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
DB04841 8438 56 None -12 23 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
4601 213526 35 None -3 17 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 269 6 0 2 3.7 Cc1ccccc1C(OCCN(C)C)c1ccccc1 nan
CHEMBL1201023 213526 35 None -3 17 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 269 6 0 2 3.7 Cc1ccccc1C(OCCN(C)C)c1ccccc1 nan
CHEMBL900 213526 35 None -3 17 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 269 6 0 2 3.7 Cc1ccccc1C(OCCN(C)C)c1ccccc1 nan
12575 8769 30 None -53 17 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1016/s0960-894x(99)00591-0
54459 8769 30 None -53 17 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1016/s0960-894x(99)00591-0
CHEMBL10316 8769 30 None -53 17 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1016/s0960-894x(99)00591-0
119584 9373 102 None -2 6 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl nan
1848 9373 102 None -2 6 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl nan
242 9373 102 None -2 6 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl nan
CHEMBL60889 9373 102 None -2 6 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl nan
DB11675 9373 102 None -2 6 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl nan
44376845 62319 1 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 419 5 0 7 3.4 COc1cc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2cc1OC 10.1016/s0960-894x(99)00591-0
CHEMBL162058 62319 1 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 419 5 0 7 3.4 COc1cc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2cc1OC 10.1016/s0960-894x(99)00591-0
6518171 175075 55 None -8 8 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
CHEMBL434063 175075 55 None -8 8 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
22120332 62819 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 389 4 0 6 3.4 COc1cccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc12 10.1016/s0960-894x(99)00591-0
CHEMBL162490 62819 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 389 4 0 6 3.4 COc1cccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc12 10.1016/s0960-894x(99)00591-0
44376984 62997 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 485 3 0 5 4.0 Cc1nc2ccc(I)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL162682 62997 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 485 3 0 5 4.0 Cc1nc2ccc(I)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
44377035 126908 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 373 3 0 5 3.7 Cc1nc2c(C)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL351200 126908 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 373 3 0 5 3.7 Cc1nc2c(C)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
3045401 62833 32 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 359 3 0 5 3.4 Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL162501 62833 32 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 359 3 0 5 3.4 Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1 10.1016/s0960-894x(99)00591-0
44376958 64253 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 373 3 0 5 3.7 Cc1ccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1 10.1016/s0960-894x(99)00591-0
CHEMBL165796 64253 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 373 3 0 5 3.7 Cc1ccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1 10.1016/s0960-894x(99)00591-0
44376954 62514 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 387 3 0 5 4.0 Cc1cc(C)n2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1 10.1016/s0960-894x(99)00591-0
CHEMBL162232 62514 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 387 3 0 5 4.0 Cc1cc(C)n2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1 10.1016/s0960-894x(99)00591-0
3151 8244 97 None -97 26 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
945 8244 97 None -97 26 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
965 8244 97 None -97 26 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
CHEMBL219916 8244 97 None -97 26 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
DB01184 8244 97 None -97 26 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
124087 8171 114 None -28 15 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 nan
7157 8171 114 None -28 15 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 nan
814 8171 114 None -28 15 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 nan
CHEMBL1172 8171 114 None -28 15 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 nan
DB00967 8171 114 None -28 15 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 nan
3168 16034 92 None -39 22 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 nan
CHEMBL1108 16034 92 None -39 22 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 nan
1816 9318 102 None -851 18 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1016/s0960-894x(99)00591-0
4205 9318 102 None -851 18 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1016/s0960-894x(99)00591-0
7241 9318 102 None -851 18 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1016/s0960-894x(99)00591-0
CHEMBL654 9318 102 None -851 18 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1016/s0960-894x(99)00591-0
DB00370 9318 102 None -851 18 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1016/s0960-894x(99)00591-0
1547484 7727 74 None -12 20 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
654 7727 74 None -12 20 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
9072 7727 74 None -12 20 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL43064 7727 74 None -12 20 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
DB00568 7727 74 None -12 20 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
135398737 7745 93 None -9 90 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
38 7745 93 None -9 90 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
722 7745 93 None -9 90 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
CHEMBL42 7745 93 None -9 90 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
DB00363 7745 93 None -9 90 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
28417 46813 49 None -1 12 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
CHEMBL1479 46813 49 None -1 12 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
5210 40112 48 None 123 4 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 nan
CHEMBL1200765 40112 48 None 123 4 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 nan
CHEMBL1419 40112 48 None 123 4 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 nan
1343 8670 62 None -91 9 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N nan
3519 8670 62 None -91 9 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N nan
522 8670 62 None -91 9 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N nan
CHEMBL862 8670 62 None -91 9 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N nan
DB01018 8670 62 None -91 9 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N nan
56645570 128267 2 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of adrenergic alpha-2B receptor (unknown origin)Inhibition of adrenergic alpha-2B receptor (unknown origin)
ChEMBL 289 2 0 3 3.9 Fc1cncc(-c2nc3cc(F)c(F)cc3n2C2CC2)c1 10.1021/acsmedchemlett.5b00054
CHEMBL3582472 128267 2 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of adrenergic alpha-2B receptor (unknown origin)Inhibition of adrenergic alpha-2B receptor (unknown origin)
ChEMBL 289 2 0 3 3.9 Fc1cncc(-c2nc3cc(F)c(F)cc3n2C2CC2)c1 10.1021/acsmedchemlett.5b00054
7000 61518 99 None - 1 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 123 1 1 2 1.3 COc1ccccc1N nan
CHEMBL1612004 61518 99 None - 1 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 123 1 1 2 1.3 COc1ccccc1N nan
134551 7146 27 None -7 21 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
271 7146 27 None -7 21 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
885 7146 27 None -7 21 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
CHEMBL1403281 7146 27 None -7 21 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
2726 7706 68 None -8 72 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
621 7706 68 None -8 72 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
83 7706 68 None -8 72 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
CHEMBL71 7706 68 None -8 72 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
DB00477 7706 68 None -8 72 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
2389 10104 118 None -104 66 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
5073 10104 118 None -104 66 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
96 10104 118 None -104 66 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
CHEMBL85 10104 118 None -104 66 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
DB00734 10104 118 None -104 66 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
55245 25352 81 None -3 3 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 429 2 1 3 5.4 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C nan
CHEMBL1276308 25352 81 None -3 3 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 429 2 1 3 5.4 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C nan
196129 74573 17 None -15 15 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 917 13 4 16 4.3 CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC nan
CHEMBL1909065 74573 17 None -15 15 Human 7.6 pIC50 = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 917 13 4 16 4.3 CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC nan
441383 27105 57 None -4 17 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL1306 27105 57 None -4 17 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
1042 8362 23 None -47 17 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C nan
148 8362 23 None -47 17 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C nan
443884 8362 23 None -47 17 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C nan
CHEMBL119443 8362 23 None -47 17 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C nan
DB01253 8362 23 None -47 17 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C nan
1212 8443 50 None -38 65 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
204 8443 50 None -38 65 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372 8443 50 None -38 65 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
CHEMBL726 8443 50 None -38 65 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
DB00623 8443 50 None -38 65 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
4209 9937 75 None -131 33 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
4893 9937 75 None -131 33 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
503 9937 75 None -131 33 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
5385 9937 75 None -131 33 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
CHEMBL2 9937 75 None -131 33 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
DB00457 9937 75 None -131 33 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
4011 89183 49 None -16 24 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 nan
CHEMBL21731 89183 49 None -16 24 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 nan
36811 8236 37 None -4 7 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
535 8236 37 None -4 7 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
937 8236 37 None -4 7 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
CHEMBL926 8236 37 None -4 7 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
DB00841 8236 37 None -4 7 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
73453 36389 24 None -1 17 Human 8.5 pIC50 = 8.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 36389 24 None -1 17 Human 8.5 pIC50 = 8.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
1043 8363 14 None -19 29 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
149 8363 14 None -19 29 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
8223 8363 14 None -19 29 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
CHEMBL442 8363 14 None -19 29 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
DB00696 8363 14 None -19 29 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
10531 8202 21 None -10 24 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
121 8202 21 None -10 24 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
888 8202 21 None -10 24 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
CHEMBL1732 8202 21 None -10 24 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
DB00320 8202 21 None -10 24 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
3236 74383 43 None -1 2 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 259 5 0 2 3.6 CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1 nan
CHEMBL1902981 74383 43 None -1 2 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 259 5 0 2 3.6 CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1 nan
5472 212597 75 None 1 3 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 nan
CHEMBL1717 212597 75 None 1 3 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 nan
CHEMBL833 212597 75 None 1 3 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 nan
26987 7736 33 None -281 21 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
6063 7736 33 None -281 21 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
671 7736 33 None -281 21 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
CHEMBL1626 7736 33 None -281 21 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
DB00283 7736 33 None -281 21 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
3038525 20321 114 None -3 3 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 435 3 0 5 5.5 O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl nan
CHEMBL119385 20321 114 None -3 3 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 435 3 0 5 5.5 O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl nan
25014630 90314 1 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibition of alpha2B adrenergic receptorInhibition of alpha2B adrenergic receptor
ChEMBL 326 3 3 4 3.3 N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1 10.1016/j.ejmech.2012.07.006
CHEMBL2203713 90314 1 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibition of alpha2B adrenergic receptorInhibition of alpha2B adrenergic receptor
ChEMBL 326 3 3 4 3.3 N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1 10.1016/j.ejmech.2012.07.006
3117 214620 103 None -2 16 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC nan
CHEMBL964 214620 103 None -2 16 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC nan
4098 39279 30 None -23 11 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 261 6 0 4 2.7 CN(C)CCN(Cc1cccs1)c1ccccn1 nan
CHEMBL1255739 39279 30 None -23 11 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 261 6 0 4 2.7 CN(C)CCN(Cc1cccs1)c1ccccn1 nan
CHEMBL1411979 39279 30 None -23 11 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 261 6 0 4 2.7 CN(C)CCN(Cc1cccs1)c1ccccn1 nan
31101 7516 40 None -33 35 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
35 7516 40 None -33 35 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
403 7516 40 None -33 35 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
CHEMBL493 7516 40 None -33 35 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
DB01200 7516 40 None -33 35 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
1016 10519 78 None -18 35 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 10519 78 None -18 35 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 10519 78 None -18 35 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 10519 78 None -18 35 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 10519 78 None -18 35 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 10519 78 None -18 35 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5318 22348 49 None -1 13 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1200348 22348 49 None -1 13 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1221 22348 49 None -1 13 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
4189 213701 96 None -18 34 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 213701 96 None -18 34 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 213701 96 None -18 34 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
5353853 24758 47 None -17 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
9556529 24758 47 None -17 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1262 24758 47 None -17 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
2351 10059 64 None -15 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
2820 10059 64 None -15 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
5035 10059 64 None -15 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
CHEMBL81 10059 64 None -15 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
DB00481 10059 64 None -15 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
26757 214757 31 None 1 2 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 187 4 0 1 2.2 C#CCN(C)[C@H](C)Cc1ccccc1 nan
CHEMBL972 214757 31 None 1 2 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 187 4 0 1 2.2 C#CCN(C)[C@H](C)Cc1ccccc1 nan
277 8083 62 None -13 50 Human 7.4 pIC50 = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
2913 8083 62 None -13 50 Human 7.4 pIC50 = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
765 8083 62 None -13 50 Human 7.4 pIC50 = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
CHEMBL516 8083 62 None -13 50 Human 7.4 pIC50 = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
DB00434 8083 62 None -13 50 Human 7.4 pIC50 = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
100 10577 58 None -35 54 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
2637 10577 58 None -35 54 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
5452 10577 58 None -35 54 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
CHEMBL479 10577 58 None -35 54 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
DB00679 10577 58 None -35 54 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
2247 7293 81 None -57 42 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 7293 81 None -57 42 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 7293 81 None -57 42 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 7293 81 None -57 42 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 7293 81 None -57 42 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2541 7573 120 None -2691 6 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
587 7573 120 None -2691 6 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
6907 7573 120 None -2691 6 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
CHEMBL1016 7573 120 None -2691 6 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
DB00796 7573 120 None -2691 6 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
DB13919 7573 120 None -2691 6 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
213 10625 55 None -3 43 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
2717 10625 55 None -3 43 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
5533 10625 55 None -3 43 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
CHEMBL621 10625 55 None -3 43 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
DB00656 10625 55 None -3 43 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
6075 156887 42 None -6 16 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 nan
CHEMBL395110 156887 42 None -6 16 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 nan
44376975 62760 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 435 5 0 5 4.6 O=c1c(CCN2CCc3oc4ccccc4c3C2)c(Cc2ccccc2)nc2ccccn12 10.1016/s0960-894x(99)00591-0
CHEMBL162436 62760 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 435 5 0 5 4.6 O=c1c(CCN2CCc3oc4ccccc4c3C2)c(Cc2ccccc2)nc2ccccn12 10.1016/s0960-894x(99)00591-0
44377007 63922 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 393 3 0 5 4.0 Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3c(Cl)cccc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL164612 63922 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 393 3 0 5 4.0 Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3c(Cl)cccc3c2C1 10.1016/s0960-894x(99)00591-0
135398745 9688 112 None -37 65 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
47 9688 112 None -37 65 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
CHEMBL715 9688 112 None -37 65 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
DB00334 9688 112 None -37 65 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
3584 10549 64 None -21 14 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
5401 10549 64 None -21 14 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
7302 10549 64 None -21 14 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
CHEMBL611 10549 64 None -21 14 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
DB01162 10549 64 None -21 14 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
1210 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
1213 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
2725 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
33036 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
4411 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
616 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
6976 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
716121 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL1201353 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL1554789 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL505 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
DB01114 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
DB13679 7705 51 None -234 21 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
150 9287 21 None -27 16 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO nan
1764 9287 21 None -27 16 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO nan
8226 9287 21 None -27 16 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO nan
CHEMBL1201356 9287 21 None -27 16 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO nan
DB00353 9287 21 None -27 16 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO nan
56645363 128268 12 None -2 4 Human 5.3 pIC50 = 5.3 Binding
Selectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b ADRA2BSelectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b ADRA2B
ChEMBL 311 3 1 4 3.8 CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1 10.6019/CHEMBL5212743
CHEMBL3582478 128268 12 None -2 4 Human 5.3 pIC50 = 5.3 Binding
Selectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b ADRA2BSelectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b ADRA2B
ChEMBL 311 3 1 4 3.8 CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1 10.6019/CHEMBL5212743
134 9292 24 None -93 67 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO nan
1775 9292 24 None -93 67 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO nan
9681 9292 24 None -93 67 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO nan
CHEMBL1065 9292 24 None -93 67 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO nan
DB00247 9292 24 None -93 67 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO nan
135 9310 43 None -8 56 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
1796 9310 43 None -8 56 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
4184 9310 43 None -8 56 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
CHEMBL6437 9310 43 None -8 56 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
DB06148 9310 43 None -8 56 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
2286 9957 51 None -4 30 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
4927 9957 51 None -4 30 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
7282 9957 51 None -4 30 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
CHEMBL643 9957 51 None -4 30 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
DB01069 9957 51 None -4 30 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
10660 21188 58 None -67 12 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 469 6 1 7 3.0 CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O nan
CHEMBL1200406 21188 58 None -67 12 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 469 6 1 7 3.0 CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O nan
3561 25849 39 None -1 11 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
CHEMBL1289 25849 39 None -1 11 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
191 7191 98 None -30 29 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
201 7191 98 None -30 29 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
2170 7191 98 None -30 29 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
CHEMBL1113 7191 98 None -30 29 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
DB00543 7191 98 None -30 29 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
3198 212292 76 None -24 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 212292 76 None -24 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 212292 76 None -24 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
2353 107889 82 None 1 5 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 336 2 0 4 3.1 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 nan
CHEMBL12089 107889 82 None 1 5 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 336 2 0 4 3.1 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 nan
CHEMBL295124 107889 82 None 1 5 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 336 2 0 4 3.1 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 nan
9885114 126382 5 None -87 12 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
ChEMBL 357 3 1 4 3.0 O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1 10.1021/jm990277d
CHEMBL346389 126382 5 None -87 12 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
ChEMBL 357 3 1 4 3.0 O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1 10.1021/jm990277d
2105 9828 37 None -8 32 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
47811 9828 37 None -8 32 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
48 9828 37 None -8 32 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
CHEMBL531 9828 37 None -8 32 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
DB01186 9828 37 None -8 32 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
2335 18620 22 None -2 12 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
8478 18620 22 None -2 12 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL1182210 18620 22 None -2 12 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL221753 18620 22 None -2 12 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
1201549 7384 24 None -13 20 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
333 7384 24 None -13 20 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
7601 7384 24 None -13 20 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
CHEMBL1201203 7384 24 None -13 20 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
CHEMBL438151 7384 24 None -13 20 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
DB00245 7384 24 None -13 20 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
5282379 201763 69 None -2 3 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 300 5 1 1 5.6 CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1 nan
CHEMBL547 201763 69 None -2 3 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 300 5 1 1 5.6 CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1 nan
107715 207724 22 None -13 20 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL1255837 207724 22 None -13 20 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL601773 207724 22 None -13 20 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
3158 63041 27 None -218 20 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 nan
CHEMBL1628227 63041 27 None -218 20 Human 7.2 pIC50 = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 nan
1530 8963 50 None -46 21 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
3827 8963 50 None -46 21 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
7206 8963 50 None -46 21 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
CHEMBL534 8963 50 None -46 21 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
DB00920 8963 50 None -46 21 Human 6.2 pIC50 = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
3191 109635 97 None -9 25 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL305660 109635 97 None -9 25 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
44240743 13529 15 None - 1 Human 5.1 pIC50 = 5.1 Binding
Binding affinity to adrenergic alpha2B receptorBinding affinity to adrenergic alpha2B receptor
ChEMBL 370 7 2 3 4.3 O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1 10.1021/jm901692q
CHEMBL1083787 13529 15 None - 1 Human 5.1 pIC50 = 5.1 Binding
Binding affinity to adrenergic alpha2B receptorBinding affinity to adrenergic alpha2B receptor
ChEMBL 370 7 2 3 4.3 O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1 10.1021/jm901692q
44190762 183659 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of radioligand from adrenergic alpha2B receptorDisplacement of radioligand from adrenergic alpha2B receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
CHEMBL461571 183659 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of radioligand from adrenergic alpha2B receptorDisplacement of radioligand from adrenergic alpha2B receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
44377006 64237 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 393 3 0 5 4.0 Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccc(Cl)cc3c2C1 10.1016/s0960-894x(99)00591-0
CHEMBL165677 64237 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
ChEMBL 393 3 0 5 4.0 Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccc(Cl)cc3c2C1 10.1016/s0960-894x(99)00591-0
155540582 179317 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 470 3 1 5 4.1 CCOc1cc(N2CCC3(CC2)C(=O)Nc2ccc(Br)cc23)nnc1C(F)(F)F 10.1021/acsmedchemlett.9b00350
CHEMBL4483761 179317 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 470 3 1 5 4.1 CCOc1cc(N2CCC3(CC2)C(=O)Nc2ccc(Br)cc23)nnc1C(F)(F)F 10.1021/acsmedchemlett.9b00350
70788951 33928 1 None -1 5 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL None None None None nan
CHEMBL1366 33928 1 None -1 5 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL None None None None nan
180 7189 56 None -7 40 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
200 7189 56 None -7 40 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
2160 7189 56 None -7 40 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
CHEMBL629 7189 56 None -7 40 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
DB00321 7189 56 None -7 40 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
118112300 162773 18 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human alpha2B-adrenergic receptorAntagonist activity at human alpha2B-adrenergic receptor
ChEMBL 430 6 2 6 3.8 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F 10.1016/j.bmcl.2017.03.085
CHEMBL4061793 162773 18 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human alpha2B-adrenergic receptorAntagonist activity at human alpha2B-adrenergic receptor
ChEMBL 430 6 2 6 3.8 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F 10.1016/j.bmcl.2017.03.085
2812 11551 101 None -29 34 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 11551 101 None -29 34 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
2803 7742 58 None -1 19 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
516 7742 58 None -1 19 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
704 7742 58 None -1 19 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
CHEMBL134 7742 58 None -1 19 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
DB00575 7742 58 None -1 19 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
1028 7079 71 None -128 30 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
139148732 7079 71 None -128 30 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
479 7079 71 None -128 30 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
5816 7079 71 None -128 30 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
CHEMBL679 7079 71 None -128 30 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
DB00668 7079 71 None -128 30 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
2585 7590 103 None -29 22 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
522 7590 103 None -29 22 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
551 7590 103 None -29 22 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
CHEMBL723 7590 103 None -29 22 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
DB01136 7590 103 None -29 22 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
1971 9641 38 None -3 30 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
2404 9641 38 None -3 30 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
4543 9641 38 None -3 30 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
CHEMBL445 9641 38 None -3 30 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
DB00540 9641 38 None -3 30 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
42636941 185728 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]RX821002 form human recombinant alpha2B adrenergic receptorDisplacement of [3H]RX821002 form human recombinant alpha2B adrenergic receptor
ChEMBL 343 5 0 5 4.4 CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 10.1016/j.bmc.2008.11.045
CHEMBL470432 185728 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]RX821002 form human recombinant alpha2B adrenergic receptorDisplacement of [3H]RX821002 form human recombinant alpha2B adrenergic receptor
ChEMBL 343 5 0 5 4.4 CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 10.1016/j.bmc.2008.11.045
49781228 23977 1 None -2 4 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 196 1 1 1 2.4 c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21 10.1021/jm1006269
CHEMBL1256414 23977 1 None -2 4 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 196 1 1 1 2.4 c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21 10.1021/jm1006269
49781228 23977 1 None -2 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 196 1 1 1 2.4 c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21 10.1021/jm1006269
CHEMBL1256414 23977 1 None -2 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 196 1 1 1 2.4 c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21 10.1021/jm1006269
52944548 23924 0 None -1 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 224 2 1 1 3.0 CC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1255723 23924 0 None -1 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 224 2 1 1 3.0 CC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1 10.1021/jm1006269
52941512 23970 0 None -1 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 210 1 1 1 2.6 C[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1256378 23970 0 None -1 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 210 1 1 1 2.6 C[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1 10.1021/jm1006269
1588 9105 27 None -1 44 Human 9.6 pKi = 9.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
28864 9105 27 None -1 44 Human 9.6 pKi = 9.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
43 9105 27 None -1 44 Human 9.6 pKi = 9.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
CHEMBL157138 9105 27 None -1 44 Human 9.6 pKi = 9.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
DB00589 9105 27 None -1 44 Human 9.6 pKi = 9.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
49781228 23977 1 None -2 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 196 1 1 1 2.4 c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21 10.1021/jm1006269
CHEMBL1256414 23977 1 None -2 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 196 1 1 1 2.4 c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21 10.1021/jm1006269
52948958 23925 0 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 238 3 1 1 3.4 CCC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1255724 23925 0 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 238 3 1 1 3.4 CCC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1 10.1021/jm1006269
49781222 24023 0 None -3 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 210 1 1 1 3.0 C[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1256609 24023 0 None -3 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 210 1 1 1 3.0 C[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
6761 74574 19 None -1 18 Human 9.1 pKi = 9.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 nan
CHEMBL1909072 74574 19 None -1 18 Human 9.1 pKi = 9.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 nan
52943739 23931 0 None -2 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 210 1 1 1 2.6 C[C@]12C[C@@]1(c1c[nH]cn1)Cc1ccccc12 10.1021/jm1006269
CHEMBL1255771 23931 0 None -2 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 210 1 1 1 2.6 C[C@]12C[C@@]1(c1c[nH]cn1)Cc1ccccc12 10.1021/jm1006269
52950140 23930 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 224 1 1 1 3.0 CC1(C)[C@@H]2c3ccccc3C[C@@]21c1c[nH]cn1 10.1021/jm1006269
CHEMBL1255770 23930 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 224 1 1 1 3.0 CC1(C)[C@@H]2c3ccccc3C[C@@]21c1c[nH]cn1 10.1021/jm1006269
102 10899 48 None -10 49 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/acs.jmedchem.9b01465
3659 10899 48 None -10 49 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/acs.jmedchem.9b01465
8969 10899 48 None -10 49 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/acs.jmedchem.9b01465
CHEMBL15245 10899 48 None -10 49 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/acs.jmedchem.9b01465
DB01392 10899 48 None -10 49 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/acs.jmedchem.9b01465
73453 36389 24 None -1 17 Human 8.9 pKi = 8.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 36389 24 None -1 17 Human 8.9 pKi = 8.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
16655023 114218 2 None -5 7 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
CHEMBL318235 114218 2 None -5 7 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
49781223 24024 0 None -3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 224 2 1 1 3.3 CC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1256610 24024 0 None -3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 224 2 1 1 3.3 CC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
108094 10196 27 None -6 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 10.1021/jm800250z
526 10196 27 None -6 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 10.1021/jm800250z
528 10196 27 None -6 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 10.1021/jm800250z
CHEMBL10332 10196 27 None -6 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 10.1021/jm800250z
1043 8363 14 None -19 29 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
149 8363 14 None -19 29 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
8223 8363 14 None -19 29 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
CHEMBL442 8363 14 None -19 29 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
DB00696 8363 14 None -19 29 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
10531 8202 21 None -10 24 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
121 8202 21 None -10 24 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
888 8202 21 None -10 24 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
CHEMBL1732 8202 21 None -10 24 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
DB00320 8202 21 None -10 24 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
49781887 23916 0 None -3 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 222 1 1 1 2.9 c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1 10.1021/jm1006269
CHEMBL1255617 23916 0 None -3 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 222 1 1 1 2.9 c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1 10.1021/jm1006269
25142456 89181 2 None -5 9 Human 8.0 pKi = 8 Binding
Binding affinity to human cloned adrenergic alpha 2B receptor receptorBinding affinity to human cloned adrenergic alpha 2B receptor receptor
ChEMBL 269 0 3 4 2.1 Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2 10.1021/jm0604979
CHEMBL217299 89181 2 None -5 9 Human 8.0 pKi = 8 Binding
Binding affinity to human cloned adrenergic alpha 2B receptor receptorBinding affinity to human cloned adrenergic alpha 2B receptor receptor
ChEMBL 269 0 3 4 2.1 Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2 10.1021/jm0604979
44579229 196395 0 None -6 3 Human 8.0 pKi = 8.0 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 468 10 1 7 2.8 CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
CHEMBL514837 196395 0 None -6 3 Human 8.0 pKi = 8.0 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 468 10 1 7 2.8 CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
44579230 188323 0 None -8 3 Human 8.0 pKi = 8.0 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 468 10 1 7 2.8 CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1 10.1016/j.bmcl.2008.08.055
CHEMBL476569 188323 0 None -8 3 Human 8.0 pKi = 8.0 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 468 10 1 7 2.8 CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1 10.1016/j.bmcl.2008.08.055
135398737 7745 93 None -9 90 Human 7.0 pKi = 7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
38 7745 93 None -9 90 Human 7.0 pKi = 7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
722 7745 93 None -9 90 Human 7.0 pKi = 7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
CHEMBL42 7745 93 None -9 90 Human 7.0 pKi = 7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
DB00363 7745 93 None -9 90 Human 7.0 pKi = 7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
135398745 9688 112 None -37 65 Human 7.0 pKi = 7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
47 9688 112 None -37 65 Human 7.0 pKi = 7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
CHEMBL715 9688 112 None -37 65 Human 7.0 pKi = 7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
DB00334 9688 112 None -37 65 Human 7.0 pKi = 7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
10220232 106497 6 None -3 6 Human 7.0 pKi = 7 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 230 1 1 2 3.5 Cc1sc(C)c2c1CCC=C2c1c[nH]cn1 10.1021/jm990569e
CHEMBL284795 106497 6 None -3 6 Human 7.0 pKi = 7 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 230 1 1 2 3.5 Cc1sc(C)c2c1CCC=C2c1c[nH]cn1 10.1021/jm990569e
12575 8769 30 None -53 17 Human 7.0 pKi = 7 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1016/j.bmcl.2006.12.094
54459 8769 30 None -53 17 Human 7.0 pKi = 7 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1016/j.bmcl.2006.12.094
CHEMBL10316 8769 30 None -53 17 Human 7.0 pKi = 7 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1016/j.bmcl.2006.12.094
10220232 106497 6 None -3 6 Rat 7.0 pKi = 7 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 230 1 1 2 3.5 Cc1sc(C)c2c1CCC=C2c1c[nH]cn1 10.1021/jm000128r
CHEMBL284795 106497 6 None -3 6 Rat 7.0 pKi = 7 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 230 1 1 2 3.5 Cc1sc(C)c2c1CCC=C2c1c[nH]cn1 10.1021/jm000128r
12574 9383 88 None -12 6 Rat 6.0 pKi = 6 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 10.1021/jm960012o
4810 9383 88 None -12 6 Rat 6.0 pKi = 6 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 10.1021/jm960012o
CHEMBL19236 9383 88 None -12 6 Rat 6.0 pKi = 6 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 10.1021/jm960012o
DB09242 9383 88 None -12 6 Rat 6.0 pKi = 6 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 10.1021/jm960012o
242 7258 124 None -64 51 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1039/C2MD00311B
34 7258 124 None -64 51 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1039/C2MD00311B
60795 7258 124 None -64 51 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1039/C2MD00311B
CHEMBL1112 7258 124 None -64 51 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1039/C2MD00311B
DB01238 7258 124 None -64 51 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1039/C2MD00311B
2337 10030 77 None -12 62 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1039/C2MD00311B
50 10030 77 None -12 62 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1039/C2MD00311B
5002 10030 77 None -12 62 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1039/C2MD00311B
CHEMBL716 10030 77 None -12 62 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1039/C2MD00311B
DB01224 10030 77 None -12 62 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1039/C2MD00311B
2389 10104 118 None -104 66 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
5073 10104 118 None -104 66 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
96 10104 118 None -104 66 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
CHEMBL85 10104 118 None -104 66 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
DB00734 10104 118 None -104 66 Human 6.0 pKi = 6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
24906203 193997 0 None -2 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2ccc3c(c2)OC(C2=NCCN2)CO3)cc1 10.1021/jm800250z
CHEMBL492445 193997 0 None -2 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2ccc3c(c2)OC(C2=NCCN2)CO3)cc1 10.1021/jm800250z
11199581 143337 0 None -3 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1ccccc1O)C1=NCCN1 10.1021/jm0408215
CHEMBL373830 143337 0 None -3 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1ccccc1O)C1=NCCN1 10.1021/jm0408215
49836307 25557 0 None -10 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 C[C@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm100977d
CHEMBL1278085 25557 0 None -10 3 Human 6.0 pKi = 6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 C[C@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm100977d
164615845 191969 0 None 1 6 Human 6.0 pKi = 6 Binding
Inhibition of alpha2b adrenergic receptor (unknown origin)Inhibition of alpha2b adrenergic receptor (unknown origin)
ChEMBL 389 2 1 4 3.7 O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1 10.1016/j.bmcl.2021.128008
CHEMBL4857492 191969 0 None 1 6 Human 6.0 pKi = 6 Binding
Inhibition of alpha2b adrenergic receptor (unknown origin)Inhibition of alpha2b adrenergic receptor (unknown origin)
ChEMBL 389 2 1 4 3.7 O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1 10.1016/j.bmcl.2021.128008
11448533 91466 0 None -1 3 Human 5.0 pKi = 5 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 267 4 0 3 3.6 CC(Oc1ccccc1-c1ccccc1)C1=NCCO1 10.1021/jm0408215
CHEMBL222591 91466 0 None -1 3 Human 5.0 pKi = 5 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 267 4 0 3 3.6 CC(Oc1ccccc1-c1ccccc1)C1=NCCO1 10.1021/jm0408215
11473729 91467 0 None -1 3 Human 5.0 pKi = 5 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 265 4 0 2 4.4 CC(Oc1ccccc1-c1ccccc1)C1=NCCC1 10.1021/jm0408215
CHEMBL222593 91467 0 None -1 3 Human 5.0 pKi = 5 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 265 4 0 2 4.4 CC(Oc1ccccc1-c1ccccc1)C1=NCCC1 10.1021/jm0408215
9856041 30886 3 None -2754 8 Rat 5.0 pKi = 5 Binding
Inhibitory constant against Alpha-2B adrenergic receptor using [3H]MK-912 radioligandInhibitory constant against Alpha-2B adrenergic receptor using [3H]MK-912 radioligand
ChEMBL 230 2 2 2 2.4 CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3 10.1021/jm030205t
CHEMBL133868 30886 3 None -2754 8 Rat 5.0 pKi = 5 Binding
Inhibitory constant against Alpha-2B adrenergic receptor using [3H]MK-912 radioligandInhibitory constant against Alpha-2B adrenergic receptor using [3H]MK-912 radioligand
ChEMBL 230 2 2 2 2.4 CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3 10.1021/jm030205t
73355415 99308 0 None -5 13 Human 6.0 pKi = 6 Binding
Inhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 277 3 1 1 2.1 C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42 10.1016/j.bmc.2013.07.045
CHEMBL2432039 99308 0 None -5 13 Human 6.0 pKi = 6 Binding
Inhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 277 3 1 1 2.1 C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42 10.1016/j.bmc.2013.07.045
3168 16034 92 None -39 22 Human 7.0 pKi = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 nan
CHEMBL1108 16034 92 None -39 22 Human 7.0 pKi = 7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 nan
44292386 108259 0 None -6 3 Human 7.0 pKi = 7.0 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 296 4 1 3 3.5 C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1 10.1021/jm9905256
CHEMBL297827 108259 0 None -6 3 Human 7.0 pKi = 7.0 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 296 4 1 3 3.5 C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1 10.1021/jm9905256
1547484 7727 74 None -12 20 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
654 7727 74 None -12 20 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
9072 7727 74 None -12 20 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL43064 7727 74 None -12 20 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
DB00568 7727 74 None -12 20 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
132584404 150127 0 None -2 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]Rauwolscine from human Alpha2B receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]Rauwolscine from human Alpha2B receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 416 3 0 2 6.7 CCCN1CC[C@H]2c3cc4ccc(C(F)(F)F)cc4nc3[C@H](CC)[C@H]3CCC[C@@H]1[C@@H]32 10.1016/j.bmcl.2016.10.065
CHEMBL3897499 150127 0 None -2 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]Rauwolscine from human Alpha2B receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]Rauwolscine from human Alpha2B receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 416 3 0 2 6.7 CCCN1CC[C@H]2c3cc4ccc(C(F)(F)F)cc4nc3[C@H](CC)[C@H]3CCC[C@@H]1[C@@H]32 10.1016/j.bmcl.2016.10.065
57345629 77960 0 None -70 4 Human 6.0 pKi = 6.0 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 246 5 1 4 2.0 CC(Oc1ccccc1OC1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL1956197 77960 0 None -70 4 Human 6.0 pKi = 6.0 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 246 5 1 4 2.0 CC(Oc1ccccc1OC1CC1)C1=NCCN1 10.1021/ml400232p
57345629 77960 0 None -70 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 246 5 1 4 2.0 CC(Oc1ccccc1OC1CC1)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956197 77960 0 None -70 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 246 5 1 4 2.0 CC(Oc1ccccc1OC1CC1)C1=NCCN1 10.1016/j.bmc.2012.01.035
28417 46813 49 None -1 12 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
CHEMBL1479 46813 49 None -1 12 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
24906243 194027 0 None -8 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 310 3 1 5 2.5 COC1(C2=NCCN2)COc2cccc(-c3ccccc3)c2O1 10.1021/jm800250z
CHEMBL492648 194027 0 None -8 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 310 3 1 5 2.5 COC1(C2=NCCN2)COc2cccc(-c3ccccc3)c2O1 10.1021/jm800250z
24906201 194132 0 None -1 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2cccc3c2OCC(C2=NCCN2)O3)cc1 10.1021/jm800250z
CHEMBL493272 194132 0 None -1 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2cccc3c2OCC(C2=NCCN2)O3)cc1 10.1021/jm800250z
9809007 179343 8 None -1047 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
CHEMBL448620 179343 8 None -1047 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
5210 40112 48 None 123 4 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 nan
CHEMBL1200765 40112 48 None 123 4 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 nan
CHEMBL1419 40112 48 None 123 4 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 nan
135398737 7745 93 None -9 90 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
38 7745 93 None -9 90 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
722 7745 93 None -9 90 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
CHEMBL42 7745 93 None -9 90 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
DB00363 7745 93 None -9 90 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
9928332 103955 5 None -5 9 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 349 6 0 3 5.0 COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1 10.1016/s0960-894x(03)00525-0
CHEMBL268258 103955 5 None -5 9 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 349 6 0 3 5.0 COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1 10.1016/s0960-894x(03)00525-0
9928332 103955 5 None -5 9 Human 8.0 pKi = 8.0 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 349 6 0 3 5.0 COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1 10.1021/jm049619s
CHEMBL268258 103955 5 None -5 9 Human 8.0 pKi = 8.0 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 349 6 0 3 5.0 COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1 10.1021/jm049619s
49781008 24022 0 None 3 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 254 3 1 2 3.3 CC(C)O[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1256608 24022 0 None 3 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 254 3 1 2 3.3 CC(C)O[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
16090596 89066 0 None -158 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 3 1 4 5.0 Cc1nc2c(C)cccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
CHEMBL217177 89066 0 None -158 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 3 1 4 5.0 Cc1nc2c(C)cccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
16090598 89230 0 None -8 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 394 3 1 4 5.4 Cc1nc2cccc(Cl)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
CHEMBL217568 89230 0 None -8 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 394 3 1 4 5.4 Cc1nc2cccc(Cl)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
5280953 104137 109 None -1 8 Human 6.0 pKi = 6.0 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 212 1 1 2 3.0 COc1ccc2c(c1)[nH]c1c(C)nccc12 10.1016/j.bmcl.2003.09.027
CHEMBL269538 104137 109 None -1 8 Human 6.0 pKi = 6.0 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 212 1 1 2 3.0 COc1ccc2c(c1)[nH]c1c(C)nccc12 10.1016/j.bmcl.2003.09.027
136680386 214482 0 None -234 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 680 16 4 8 4.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1 10.1016/s0960-894x(99)00484-9
44328801 214482 0 None -234 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 680 16 4 8 4.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL95578 214482 0 None -234 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 680 16 4 8 4.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1 10.1016/s0960-894x(99)00484-9
1343 8670 62 None -91 9 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N nan
3519 8670 62 None -91 9 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N nan
522 8670 62 None -91 9 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N nan
CHEMBL862 8670 62 None -91 9 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N nan
DB01018 8670 62 None -91 9 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N nan
7000 61518 99 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 123 1 1 2 1.3 COc1ccccc1N nan
CHEMBL1612004 61518 99 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 123 1 1 2 1.3 COc1ccccc1N nan
11140033 27455 0 None -12 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 265 4 2 3 3.2 CC(Nc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm0408215
CHEMBL130884 27455 0 None -12 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 265 4 2 3 3.2 CC(Nc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm0408215
16090595 148179 0 None -138 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 3 1 4 5.0 Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1 10.1021/jm060262x
CHEMBL383978 148179 0 None -138 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 3 1 4 5.0 Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1 10.1021/jm060262x
135418497 69813 0 None -501 4 Human 6.9 pKi = 6.9 Binding
Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin
ChEMBL 391 4 1 5 2.5 COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4NC(=O)N32)CC1 10.1021/jm970159v
CHEMBL1788222 69813 0 None -501 4 Human 6.9 pKi = 6.9 Binding
Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin
ChEMBL 391 4 1 5 2.5 COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4NC(=O)N32)CC1 10.1021/jm970159v
1268096 22937 26 None -4 4 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 352 1 1 4 3.2 COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12 10.1021/jm00019a001
CHEMBL122404 22937 26 None -4 4 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 352 1 1 4 3.2 COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12 10.1021/jm00019a001
9809007 179343 8 None -1047 6 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
CHEMBL448620 179343 8 None -1047 6 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
21392988 211596 4 None 1 3 Human 4.9 pKi = 4.9 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 156 0 0 4 -0.3 C1COC(N2CCOCC2)=N1 10.1016/0960-894X(94)85032-1
CHEMBL75201 211596 4 None 1 3 Human 4.9 pKi = 4.9 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 156 0 0 4 -0.3 C1COC(N2CCOCC2)=N1 10.1016/0960-894X(94)85032-1
134551 7146 27 None -7 21 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
271 7146 27 None -7 21 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
885 7146 27 None -7 21 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
CHEMBL1403281 7146 27 None -7 21 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
2726 7706 68 None -8 72 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
621 7706 68 None -8 72 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
83 7706 68 None -8 72 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
CHEMBL71 7706 68 None -8 72 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
DB00477 7706 68 None -8 72 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
2389 10104 118 None -104 66 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
5073 10104 118 None -104 66 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
96 10104 118 None -104 66 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
CHEMBL85 10104 118 None -104 66 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
DB00734 10104 118 None -104 66 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
196129 74573 17 None -15 15 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 917 13 4 16 4.3 CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC nan
CHEMBL1909065 74573 17 None -15 15 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 917 13 4 16 4.3 CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC nan
136019934 151308 0 None -12 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 462 7 1 7 3.6 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2 10.1016/j.bmc.2007.03.053
CHEMBL390718 151308 0 None -12 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 462 7 1 7 3.6 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2 10.1016/j.bmc.2007.03.053
44324887 171794 0 None -15 3 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 419 6 0 6 3.1 COc1ccc2c(c1)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL422597 171794 0 None -15 3 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 419 6 0 6 3.1 COc1ccc2c(c1)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
10398419 123419 0 None -13 2 Rat 5.9 pKi = 5.9 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 216 1 1 3 1.6 COc1ccc2c(c1)CCC1(CN=CN1)C2 10.1021/jm00020a021
CHEMBL336970 123419 0 None -13 2 Rat 5.9 pKi = 5.9 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 216 1 1 3 1.6 COc1ccc2c(c1)CCC1(CN=CN1)C2 10.1021/jm00020a021
3072540 89190 13 None -32 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 382 4 1 4 5.3 CCN1CCN(c2ccc(Nc3c4ccccc4nc4ccccc34)cc2)CC1 10.1021/jm060262x
CHEMBL217366 89190 13 None -32 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 382 4 1 4 5.3 CCN1CCN(c2ccc(Nc3c4ccccc4nc4ccccc34)cc2)CC1 10.1021/jm060262x
9794524 211622 2 None -38 3 Rat 5.9 pKi = 5.9 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 225 2 2 4 2.4 Cc1c(Nc2ncc[nH]2)ccc2nccnc12 10.1021/jm9605142
CHEMBL75491 211622 2 None -38 3 Rat 5.9 pKi = 5.9 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 225 2 2 4 2.4 Cc1c(Nc2ncc[nH]2)ccc2nccnc12 10.1021/jm9605142
24906160 176235 0 None -1 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 247 5 1 5 1.4 CO/N=C/c1ccccc1OC(C)C1=NCCN1 10.1021/jm800250z
CHEMBL442815 176235 0 None -1 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 247 5 1 5 1.4 CO/N=C/c1ccccc1OC(C)C1=NCCN1 10.1021/jm800250z
55245 25352 81 None -3 3 Human 4.9 pKi = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 429 2 1 3 5.4 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C nan
CHEMBL1276308 25352 81 None -3 3 Human 4.9 pKi = 4.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 429 2 1 3 5.4 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C nan
101333429 123854 0 None -3090 6 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1 10.1021/jm00019a001
CHEMBL3392247 123854 0 None -3090 6 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1 10.1021/jm00019a001
44421258 91521 0 None -3 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 264 3 1 3 2.8 c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1 10.1021/jm0408215
CHEMBL1204386 91521 0 None -3 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 264 3 1 3 2.8 c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1 10.1021/jm0408215
CHEMBL222933 91521 0 None -3 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 264 3 1 3 2.8 c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1 10.1021/jm0408215
441383 27105 57 None -4 17 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL1306 27105 57 None -4 17 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
10651654 118260 0 None -676 6 Human 5.9 pKi = 5.9 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 631 9 2 5 7.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)c(Cl)c1 10.1021/jm980077m
CHEMBL327712 118260 0 None -676 6 Human 5.9 pKi = 5.9 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 631 9 2 5 7.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)c(Cl)c1 10.1021/jm980077m
10674896 213423 0 None -691 6 Human 5.9 pKi = 5.9 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 588 9 2 6 6.4 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C#N)cc1 10.1021/jm980077m
CHEMBL89243 213423 0 None -691 6 Human 5.9 pKi = 5.9 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 588 9 2 6 6.4 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C#N)cc1 10.1021/jm980077m
50898777 63214 0 None -11748 8 Human 5.9 pKi = 5.9 Binding
Binding affinity to alpha2B adrenergic receptorBinding affinity to alpha2B adrenergic receptor
ChEMBL 441 9 1 6 3.6 COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 10.1016/j.bmc.2010.10.011
CHEMBL1632158 63214 0 None -11748 8 Human 5.9 pKi = 5.9 Binding
Binding affinity to alpha2B adrenergic receptorBinding affinity to alpha2B adrenergic receptor
ChEMBL 441 9 1 6 3.6 COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 10.1016/j.bmc.2010.10.011
11043720 98947 0 None -6 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
CHEMBL242265 98947 0 None -6 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
11043720 98947 0 None -6 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
CHEMBL242265 98947 0 None -6 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
10473701 90013 0 None -234 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 360 3 1 4 4.8 Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)(C)C2)cc1 10.1021/jm060262x
CHEMBL218679 90013 0 None -234 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 360 3 1 4 4.8 Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)(C)C2)cc1 10.1021/jm060262x
73349361 99323 0 None -1 7 Human 5.9 pKi = 5.9 Binding
Inhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 279 4 0 1 3.3 CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41 10.1016/j.bmc.2013.07.045
CHEMBL2432058 99323 0 None -1 7 Human 5.9 pKi = 5.9 Binding
Inhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 279 4 0 1 3.3 CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41 10.1016/j.bmc.2013.07.045
10044968 103320 0 None -85 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 3 1 4 5.0 Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1 10.1021/jm060262x
CHEMBL262901 103320 0 None -85 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 3 1 4 5.0 Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1 10.1021/jm060262x
10326069 46070 1 None -72 9 Human 5.9 pKi = 5.9 Binding
Binding affinity for recombinant human Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand.Binding affinity for recombinant human Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand.
ChEMBL 589 10 3 8 3.3 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980506g
CHEMBL147077 46070 1 None -72 9 Human 5.9 pKi = 5.9 Binding
Binding affinity for recombinant human Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand.Binding affinity for recombinant human Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand.
ChEMBL 589 10 3 8 3.3 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980506g
4209 9937 75 None -131 33 Human 7.9 pKi = 7.9 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
4893 9937 75 None -131 33 Human 7.9 pKi = 7.9 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
503 9937 75 None -131 33 Human 7.9 pKi = 7.9 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
5385 9937 75 None -131 33 Human 7.9 pKi = 7.9 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
CHEMBL2 9937 75 None -131 33 Human 7.9 pKi = 7.9 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
DB00457 9937 75 None -131 33 Human 7.9 pKi = 7.9 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
1212 8443 50 None -38 65 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
204 8443 50 None -38 65 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372 8443 50 None -38 65 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
CHEMBL726 8443 50 None -38 65 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
DB00623 8443 50 None -38 65 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
10527469 163044 3 None -28 16 Rat 7.9 pKi = 7.9 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 10.1021/jm970364a
CHEMBL40650 163044 3 None -28 16 Rat 7.9 pKi = 7.9 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 10.1021/jm970364a
11203101 78458 0 None -1995 3 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards alpha-2b adrenergic receptorIn vitro binding affinity towards alpha-2b adrenergic receptor
ChEMBL 515 7 3 5 4.1 O=C(CCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O)OCc1ccccc1 10.1016/j.bmcl.2005.03.116
CHEMBL196451 78458 0 None -1995 3 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards alpha-2b adrenergic receptorIn vitro binding affinity towards alpha-2b adrenergic receptor
ChEMBL 515 7 3 5 4.1 O=C(CCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O)OCc1ccccc1 10.1016/j.bmcl.2005.03.116
57399145 77959 0 None -13 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 234 5 1 4 1.9 CCOc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956196 77959 0 None -13 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 234 5 1 4 1.9 CCOc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
12699315 83073 0 None 1 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 243 1 2 3 2.8 CC1CNC(Nc2c(Cl)cccc2Cl)=N1 10.1016/j.bmc.2012.06.008
CHEMBL2058631 83073 0 None 1 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 243 1 2 3 2.8 CC1CNC(Nc2c(Cl)cccc2Cl)=N1 10.1016/j.bmc.2012.06.008
1042 8362 23 None -47 17 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C nan
148 8362 23 None -47 17 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C nan
443884 8362 23 None -47 17 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C nan
CHEMBL119443 8362 23 None -47 17 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C nan
DB01253 8362 23 None -47 17 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C nan
16090594 88900 0 None -15 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 3 1 4 5.4 Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1C 10.1021/jm060262x
CHEMBL216674 88900 0 None -15 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 3 1 4 5.4 Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1C 10.1021/jm060262x
4209 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
4893 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
503 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
5385 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
CHEMBL2 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
DB00457 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
4011 89183 49 None -16 24 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 nan
CHEMBL21731 89183 49 None -16 24 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 nan
10045713 172884 0 None -575 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 386 3 1 4 5.3 Cc1nc2ccccc2c(Nc2ccc(N3CCN4CCCCC4C3)cc2)c1C 10.1021/jm060262x
CHEMBL425983 172884 0 None -575 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 386 3 1 4 5.3 Cc1nc2ccccc2c(Nc2ccc(N3CCN4CCCCC4C3)cc2)c1C 10.1021/jm060262x
10350094 20589 0 None -77 2 Human 6.9 pKi = 6.9 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 746 8 6 6 5.4 O=C(NCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL1195716 20589 0 None -77 2 Human 6.9 pKi = 6.9 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 746 8 6 6 5.4 O=C(NCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL555190 20589 0 None -77 2 Human 6.9 pKi = 6.9 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 746 8 6 6 5.4 O=C(NCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
36811 8236 37 None -4 7 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
535 8236 37 None -4 7 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
937 8236 37 None -4 7 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
CHEMBL926 8236 37 None -4 7 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
DB00841 8236 37 None -4 7 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
44438168 100593 0 None -389 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 533 7 0 7 4.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL247665 100593 0 None -389 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 533 7 0 7 4.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2 10.1016/j.bmcl.2006.12.094
3236 74383 43 None -1 2 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 259 5 0 2 3.6 CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1 nan
CHEMBL1902981 74383 43 None -1 2 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 259 5 0 2 3.6 CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1 nan
5472 212597 75 None 1 3 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 nan
CHEMBL1717 212597 75 None 1 3 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 nan
CHEMBL833 212597 75 None 1 3 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 nan
44424855 92229 0 None -1 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 467 7 0 7 3.3 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2 10.1016/j.bmc.2007.03.053
CHEMBL226636 92229 0 None -1 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 467 7 0 7 3.3 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2 10.1016/j.bmc.2007.03.053
44324765 118345 0 None -7 5 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 449 7 0 7 3.1 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL328114 118345 0 None -7 5 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 449 7 0 7 3.1 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
44324972 170151 0 None -70 4 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL419316 170151 0 None -70 4 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
44324737 214017 0 None -12 5 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL92860 214017 0 None -12 5 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
44324765 118345 0 None -7 5 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 449 7 0 7 3.1 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2 10.1021/jm049619s
CHEMBL328114 118345 0 None -7 5 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 449 7 0 7 3.1 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2 10.1021/jm049619s
44324972 170151 0 None -70 4 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2 10.1021/jm049619s
CHEMBL419316 170151 0 None -70 4 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2 10.1021/jm049619s
44324737 214017 0 None -12 5 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2 10.1021/jm049619s
CHEMBL92860 214017 0 None -12 5 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2 10.1021/jm049619s
518 10384 1 None 1 6 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 299 0 0 2 3.8 CN1CCc2c3c(C1)c(Br)oc3ccc2Cl 10.1021/jm00019a001
9839317 10384 1 None 1 6 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 299 0 0 2 3.8 CN1CCc2c3c(C1)c(Br)oc3ccc2Cl 10.1021/jm00019a001
CHEMBL123138 10384 1 None 1 6 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 299 0 0 2 3.8 CN1CCc2c3c(C1)c(Br)oc3ccc2Cl 10.1021/jm00019a001
25110718 200088 0 None -16 3 Human 7.8 pKi = 7.8 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 488 8 1 7 3.5 O=C(NCCN1CCCN(C[C@H]2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1 10.1016/j.bmcl.2008.08.055
CHEMBL524153 200088 0 None -16 3 Human 7.8 pKi = 7.8 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 488 8 1 7 3.5 O=C(NCCN1CCCN(C[C@H]2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1 10.1016/j.bmcl.2008.08.055
441975 23223 56 None -2 3 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 352 1 1 4 3.2 COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 10.1021/jm00019a001
CHEMBL123325 23223 56 None -2 3 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 352 1 1 4 3.2 COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 10.1021/jm00019a001
599482 209763 9 None -1 5 Rat 6.9 pKi = 6.9 Binding
Binding affinity at alpha 2B adrenergic receptor of rat.Binding affinity at alpha 2B adrenergic receptor of rat.
ChEMBL 202 1 2 2 1.8 COc1ccc2c3c([nH]c2c1)CNCC3 10.1016/j.bmcl.2003.11.078
CHEMBL6310 209763 9 None -1 5 Rat 6.9 pKi = 6.9 Binding
Binding affinity at alpha 2B adrenergic receptor of rat.Binding affinity at alpha 2B adrenergic receptor of rat.
ChEMBL 202 1 2 2 1.8 COc1ccc2c3c([nH]c2c1)CNCC3 10.1016/j.bmcl.2003.11.078
599482 209763 9 None 1 5 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 202 1 2 2 1.8 COc1ccc2c3c([nH]c2c1)CNCC3 10.1016/j.bmcl.2003.09.027
CHEMBL6310 209763 9 None 1 5 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 202 1 2 2 1.8 COc1ccc2c3c([nH]c2c1)CNCC3 10.1016/j.bmcl.2003.09.027
9816048 194057 0 None -14 3 Rat 6.9 pKi = 6.9 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 231 1 4 5 1.2 Cc1c(NC2=NCCN2)ccc2c1NCCN2 10.1021/jm960359r
CHEMBL49284 194057 0 None -14 3 Rat 6.9 pKi = 6.9 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 231 1 4 5 1.2 Cc1c(NC2=NCCN2)ccc2c1NCCN2 10.1021/jm960359r
9816063 109851 0 None -10 6 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 232 1 1 2 3.6 Cc1sc(C)c2c1CCCC2c1c[nH]cn1 10.1021/jm990569e
CHEMBL30739 109851 0 None -10 6 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 232 1 1 2 3.6 Cc1sc(C)c2c1CCCC2c1c[nH]cn1 10.1021/jm990569e
9816063 109851 0 None -10 6 Rat 6.9 pKi = 6.9 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 232 1 1 2 3.6 Cc1sc(C)c2c1CCCC2c1c[nH]cn1 10.1021/jm000128r
CHEMBL30739 109851 0 None -10 6 Rat 6.9 pKi = 6.9 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 232 1 1 2 3.6 Cc1sc(C)c2c1CCCC2c1c[nH]cn1 10.1021/jm000128r
9971924 191005 0 None -4 3 Human 6.9 pKi = 6.9 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 298 5 1 3 3.4 c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1 10.1021/jm9905256
CHEMBL48341 191005 0 None -4 3 Human 6.9 pKi = 6.9 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 298 5 1 3 3.4 c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1 10.1021/jm9905256
122295 16640 7 None -4 9 Human 6.9 pKi = 6.9 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 279 3 0 2 3.7 CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2 10.1021/jm00018a001
CHEMBL114166 16640 7 None -4 9 Human 6.9 pKi = 6.9 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 279 3 0 2 3.7 CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2 10.1021/jm00018a001
26987 7736 33 None -281 21 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
6063 7736 33 None -281 21 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
671 7736 33 None -281 21 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
CHEMBL1626 7736 33 None -281 21 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
DB00283 7736 33 None -281 21 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
122295 16640 7 None -4 9 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 279 3 0 2 3.7 CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2 10.1021/jm00019a001
CHEMBL114166 16640 7 None -4 9 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 279 3 0 2 3.7 CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2 10.1021/jm00019a001
56645363 128268 12 None -2 4 Human 5.8 pKi = 5.8 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000313b ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000313b ADRA2B
ChEMBL 311 3 1 4 3.8 CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1 10.6019/CHEMBL5212743
CHEMBL3582478 128268 12 None -2 4 Human 5.8 pKi = 5.8 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000313b ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000313b ADRA2B
ChEMBL 311 3 1 4 3.8 CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1 10.6019/CHEMBL5212743
49781005 23986 0 None -3 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 226 2 1 2 2.5 CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1256503 23986 0 None -3 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 226 2 1 2 2.5 CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
132060720 169268 0 None -3 9 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 315 4 0 2 4.9 COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1 10.1016/j.ejmech.2018.02.024
CHEMBL4167315 169268 0 None -3 9 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 315 4 0 2 4.9 COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1 10.1016/j.ejmech.2018.02.024
9827677 175201 0 None -724 7 Human 6.8 pKi = 6.8 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 510 7 2 4 4.2 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
CHEMBL43491 175201 0 None -724 7 Human 6.8 pKi = 6.8 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 510 7 2 4 4.2 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
3038525 20321 114 None -3 3 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 435 3 0 5 5.5 O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl nan
CHEMBL119385 20321 114 None -3 3 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 435 3 0 5 5.5 O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl nan
3117 214620 103 None -2 16 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC nan
CHEMBL964 214620 103 None -2 16 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC nan
16090630 90012 0 None -389 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 390 4 2 5 4.3 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)(C)C3)cc2)c1CO 10.1021/jm060262x
CHEMBL218675 90012 0 None -389 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 390 4 2 5 4.3 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)(C)C3)cc2)c1CO 10.1021/jm060262x
102 10899 48 None -10 49 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2006.12.094
3659 10899 48 None -10 49 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2006.12.094
8969 10899 48 None -10 49 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2006.12.094
CHEMBL15245 10899 48 None -10 49 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2006.12.094
DB01392 10899 48 None -10 49 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2006.12.094
44324800 213727 0 None -22 7 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL91157 213727 0 None -22 7 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
10946567 23241 0 None -12 6 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 265 1 0 2 4.1 CCc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm00019a001
CHEMBL123448 23241 0 None -12 6 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 265 1 0 2 4.1 CCc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm00019a001
44579272 193874 0 None -5 3 Human 7.8 pKi = 7.8 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 499 7 0 9 4.3 c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1 10.1016/j.bmcl.2008.08.055
CHEMBL491420 193874 0 None -5 3 Human 7.8 pKi = 7.8 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 499 7 0 9 4.3 c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1 10.1016/j.bmcl.2008.08.055
3930 8932 43 None -53 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 368 3 1 4 4.9 CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2 10.1021/jm060262x
540335 8932 43 None -53 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 368 3 1 4 4.9 CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2 10.1021/jm060262x
CHEMBL106525 8932 43 None -53 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 368 3 1 4 4.9 CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2 10.1021/jm060262x
10490084 211737 1 None -7 3 Rat 5.8 pKi = 5.8 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 237 2 2 2 2.9 Brc1ccccc1Nc1ncc[nH]1 10.1021/jm9605142
CHEMBL76457 211737 1 None -7 3 Rat 5.8 pKi = 5.8 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 237 2 2 2 2.9 Brc1ccccc1Nc1ncc[nH]1 10.1021/jm9605142
12114850 20020 0 None -57 2 Human 5.8 pKi = 5.8 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 704 5 6 6 4.2 O=C(NCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL1191424 20020 0 None -57 2 Human 5.8 pKi = 5.8 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 704 5 6 6 4.2 O=C(NCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL542520 20020 0 None -57 2 Human 5.8 pKi = 5.8 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 704 5 6 6 4.2 O=C(NCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
10841190 113819 0 None -213 6 Human 5.8 pKi = 5.8 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 593 10 2 6 6.5 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC)cc1 10.1021/jm980077m
CHEMBL315538 113819 0 None -213 6 Human 5.8 pKi = 5.8 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 593 10 2 6 6.5 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC)cc1 10.1021/jm980077m
4098 39279 30 None -23 11 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 261 6 0 4 2.7 CN(C)CCN(Cc1cccs1)c1ccccn1 nan
CHEMBL1255739 39279 30 None -23 11 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 261 6 0 4 2.7 CN(C)CCN(Cc1cccs1)c1ccccn1 nan
CHEMBL1411979 39279 30 None -23 11 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 261 6 0 4 2.7 CN(C)CCN(Cc1cccs1)c1ccccn1 nan
10081626 27867 0 None -12 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 204 0 1 2 1.7 Fc1cccc2c1CC1(CC2)CN=CN1 10.1021/jm00020a021
CHEMBL131220 27867 0 None -12 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 204 0 1 2 1.7 Fc1cccc2c1CC1(CC2)CN=CN1 10.1021/jm00020a021
44438166 100592 0 None -371 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 467 8 2 7 3.5 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL247664 100592 0 None -371 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 467 8 2 7 3.5 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2 10.1016/j.bmcl.2006.12.094
9906978 49485 2 None -125 12 Human 5.8 pKi = 5.8 Binding
Binding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assay
ChEMBL 361 6 1 3 4.0 O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 10.1016/j.bmcl.2006.03.057
CHEMBL150161 49485 2 None -125 12 Human 5.8 pKi = 5.8 Binding
Binding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assay
ChEMBL 361 6 1 3 4.0 O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 10.1016/j.bmcl.2006.03.057
11221758 91392 0 None -8 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 CC(Oc1ccccc1-c1ccccc1[N+](=O)[O-])C1=NCCN1 10.1021/jm0408215
CHEMBL222138 91392 0 None -8 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 CC(Oc1ccccc1-c1ccccc1[N+](=O)[O-])C1=NCCN1 10.1021/jm0408215
122442272 145126 0 None -26 15 Human 5.8 pKi = 5.8 Binding
Binding affinity to human alpha-2B adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2B adrenergic receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
CHEMBL3769968 145126 0 None -26 15 Human 5.8 pKi = 5.8 Binding
Binding affinity to human alpha-2B adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2B adrenergic receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
CHEMBL3771384 145126 0 None -26 15 Human 5.8 pKi = 5.8 Binding
Binding affinity to human alpha-2B adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2B adrenergic receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
118717249 121903 0 None -2 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting
ChEMBL 219 1 2 3 0.5 Fc1cccc2cnn(N=C3NCCN3)c12 10.1016/j.ejmech.2014.09.083
CHEMBL3343700 121903 0 None -2 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting
ChEMBL 219 1 2 3 0.5 Fc1cccc2cnn(N=C3NCCN3)c12 10.1016/j.ejmech.2014.09.083
44269140 40327 0 None -19 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 248 5 1 4 2.2 CC(C)Oc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL14208 40327 0 None -19 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 248 5 1 4 2.2 CC(C)Oc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
16757182 160030 0 None -21 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm061487a
CHEMBL397753 160030 0 None -21 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm061487a
16757182 160030 0 None -21 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm100977d
CHEMBL397753 160030 0 None -21 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm100977d
10262765 123333 0 None -13 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 216 1 1 3 1.6 COc1cccc2c1CCC1(CN=CN1)C2 10.1021/jm00020a021
CHEMBL336332 123333 0 None -13 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 216 1 1 3 1.6 COc1cccc2c1CCC1(CN=CN1)C2 10.1021/jm00020a021
31101 7516 40 None -33 35 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
35 7516 40 None -33 35 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
403 7516 40 None -33 35 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
CHEMBL493 7516 40 None -33 35 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
DB01200 7516 40 None -33 35 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
44324906 213566 0 None -31 3 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 419 6 0 6 3.1 COc1ccc2c(c1)OCC1C2=NOC1CN1CCN(C/C=C/c2ccccc2)CC1 10.1016/s0960-894x(03)00525-0
CHEMBL90247 213566 0 None -31 3 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 419 6 0 6 3.1 COc1ccc2c(c1)OCC1C2=NOC1CN1CCN(C/C=C/c2ccccc2)CC1 10.1016/s0960-894x(03)00525-0
123981 23231 22 None -8 8 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1 10.1021/jm00019a001
CHEMBL123349 23231 22 None -8 8 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1 10.1021/jm00019a001
CHEMBL536803 23231 22 None -8 8 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1 10.1021/jm00019a001
11750482 154199 0 None -19 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 419 6 0 6 5.3 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL392991 154199 0 None -19 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 419 6 0 6 5.3 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2 10.1016/j.bmcl.2006.12.094
3303 9024 46 None -234 15 Human 6.8 pKi = 6.8 Binding
Inhibition of alpha2B adrenergic receptor (unknown origin)Inhibition of alpha2B adrenergic receptor (unknown origin)
ChEMBL 326 3 1 3 3.5 Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 10.1021/acs.jmedchem.7b00151
5311200 9024 46 None -234 15 Human 6.8 pKi = 6.8 Binding
Inhibition of alpha2B adrenergic receptor (unknown origin)Inhibition of alpha2B adrenergic receptor (unknown origin)
ChEMBL 326 3 1 3 3.5 Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 10.1021/acs.jmedchem.7b00151
CHEMBL267014 9024 46 None -234 15 Human 6.8 pKi = 6.8 Binding
Inhibition of alpha2B adrenergic receptor (unknown origin)Inhibition of alpha2B adrenergic receptor (unknown origin)
ChEMBL 326 3 1 3 3.5 Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 10.1021/acs.jmedchem.7b00151
2803 7742 58 None -1 19 Rat 6.8 pKi = 6.8 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm000128r
516 7742 58 None -1 19 Rat 6.8 pKi = 6.8 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm000128r
704 7742 58 None -1 19 Rat 6.8 pKi = 6.8 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm000128r
CHEMBL134 7742 58 None -1 19 Rat 6.8 pKi = 6.8 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm000128r
DB00575 7742 58 None -1 19 Rat 6.8 pKi = 6.8 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm000128r
CHEMBL5273955 200567 0 None 1 2 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]RX821002 from human alpha2B receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysisDisplacement of [3H]RX821002 from human alpha2B receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysis
ChEMBL 305 3 2 2 4.1 C#Cc1cc(Nc2ccccc2C(=O)O)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.2c01997
1016 10519 78 None -18 35 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 10519 78 None -18 35 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 10519 78 None -18 35 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 10519 78 None -18 35 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 10519 78 None -18 35 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 10519 78 None -18 35 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
44424855 92229 0 None -1 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 467 7 0 7 3.3 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2 10.1016/j.bmc.2007.03.053
CHEMBL226636 92229 0 None -1 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 467 7 0 7 3.3 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2 10.1016/j.bmc.2007.03.053
44288945 175694 0 None -407 7 Human 6.8 pKi = 6.8 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 485 7 2 3 4.4 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
CHEMBL43860 175694 0 None -407 7 Human 6.8 pKi = 6.8 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 485 7 2 3 4.4 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
11000184 19824 0 None -37 6 Human 5.8 pKi = 5.8 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL1190038 19824 0 None -37 6 Human 5.8 pKi = 5.8 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL540035 19824 0 None -37 6 Human 5.8 pKi = 5.8 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
57395663 77956 0 None -8 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 258 3 1 3 2.5 CC(Oc1ccccc1C(F)(F)F)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956193 77956 0 None -8 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 258 3 1 3 2.5 CC(Oc1ccccc1C(F)(F)F)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL4576555 220796 5 None -1 19 Human 5.8 pKi = 5.8 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 10.6019/CHEMBL4507307
5318 22348 49 None -1 13 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1200348 22348 49 None -1 13 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1221 22348 49 None -1 13 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
4189 213701 96 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 213701 96 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 213701 96 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL4576555 220796 5 None -1 19 Human 5.8 pKi = 5.8 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000705a ADRA2B
ChEMBL None None None CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 10.6019/CHEMBL5212743
CHEMBL4576555 220796 5 None -1 19 Human 5.8 pKi = 5.8 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 10.6019/CHEMBL4507307
44269122 104885 2 None -6 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 190 3 1 3 1.5 CC(Oc1ccccc1)C1=NCCN1 10.1021/jm800250z
CHEMBL273485 104885 2 None -6 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 190 3 1 3 1.5 CC(Oc1ccccc1)C1=NCCN1 10.1021/jm800250z
45487144 204480 0 None -6 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 190 2 1 3 1.7 CC(OC1=NCCN1)c1ccccc1 10.1021/jm901262f
CHEMBL571314 204480 0 None -6 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 190 2 1 3 1.7 CC(OC1=NCCN1)c1ccccc1 10.1021/jm901262f
44269122 104885 2 None -6 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 190 3 1 3 1.5 CC(Oc1ccccc1)C1=NCCN1 10.1021/jm100977d
CHEMBL273485 104885 2 None -6 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 190 3 1 3 1.5 CC(Oc1ccccc1)C1=NCCN1 10.1021/jm100977d
11034737 211307 0 None -8 6 Human 5.8 pKi = 5.8 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 289 4 2 4 2.8 CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72724 211307 0 None -8 6 Human 5.8 pKi = 5.8 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 289 4 2 4 2.8 CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1 10.1021/jm000542r
24906202 193996 0 None -5 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2ccc3c(c2)OCC(C2=NCCN2)O3)cc1 10.1021/jm800250z
CHEMBL492444 193996 0 None -5 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2ccc3c(c2)OCC(C2=NCCN2)O3)cc1 10.1021/jm800250z
10123375 20022 0 None -123 2 Human 6.8 pKi = 6.8 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 760 9 6 6 5.8 O=C(NCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL1191431 20022 0 None -123 2 Human 6.8 pKi = 6.8 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 760 9 6 6 5.8 O=C(NCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL542527 20022 0 None -123 2 Human 6.8 pKi = 6.8 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 760 9 6 6 5.8 O=C(NCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
5353853 24758 47 None -17 15 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
9556529 24758 47 None -17 15 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1262 24758 47 None -17 15 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
16090600 175960 0 None -16 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 360 6 2 4 5.1 Cc1nc2ccccc2c(Nc2ccc(NCCN3CCCC3)cc2)c1C 10.1021/jm060262x
CHEMBL440594 175960 0 None -16 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 360 6 2 4 5.1 Cc1nc2ccccc2c(Nc2ccc(NCCN3CCCC3)cc2)c1C 10.1021/jm060262x
2351 10059 64 None -15 21 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
2820 10059 64 None -15 21 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
5035 10059 64 None -15 21 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
CHEMBL81 10059 64 None -15 21 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
DB00481 10059 64 None -15 21 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
9894665 110590 1 None -512 8 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligandBinding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligand
ChEMBL 585 10 2 8 3.3 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL309106 110590 1 None -512 8 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligandBinding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligand
ChEMBL 585 10 2 8 3.3 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 10.1021/jm9905918
127036932 144126 0 None -5 22 Human 6.8 pKi = 6.8 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 274 7 1 1 4.0 C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL3752900 144126 0 None -5 22 Human 6.8 pKi = 6.8 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 274 7 1 1 4.0 C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 10.1016/j.bmcl.2015.12.053
131801156 163934 14 None -77 5 Human 5.8 pKi = 5.8 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000316b ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000316b ADRA2B
ChEMBL 417 5 2 6 4.4 O=C1CCc2cc(Nc3cc(OC4CCOCC4)c([N+](=O)[O-])cc3Cl)ccc2N1 10.6019/CHEMBL5212743
132486799 163934 14 None -77 5 Human 5.8 pKi = 5.8 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000316b ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000316b ADRA2B
ChEMBL 417 5 2 6 4.4 O=C1CCc2cc(Nc3cc(OC4CCOCC4)c([N+](=O)[O-])cc3Cl)ccc2N1 10.6019/CHEMBL5212743
CHEMBL4075278 163934 14 None -77 5 Human 5.8 pKi = 5.8 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000316b ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000316b ADRA2B
ChEMBL 417 5 2 6 4.4 O=C1CCc2cc(Nc3cc(OC4CCOCC4)c([N+](=O)[O-])cc3Cl)ccc2N1 10.6019/CHEMBL5212743
9926529 16161 2 None -25 5 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL111496 16161 2 None -25 5 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
185076 193869 5 None -4 7 Rat 7.8 pKi = 7.8 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12 10.1021/jm960359r
CHEMBL49137 193869 5 None -4 7 Rat 7.8 pKi = 7.8 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12 10.1021/jm960359r
277 8083 62 None -13 50 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
2913 8083 62 None -13 50 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
765 8083 62 None -13 50 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
CHEMBL516 8083 62 None -13 50 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
DB00434 8083 62 None -13 50 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
185076 193869 5 None -4 7 Rat 7.8 pKi = 7.8 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12 10.1021/jm9605142
CHEMBL49137 193869 5 None -4 7 Rat 7.8 pKi = 7.8 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12 10.1021/jm9605142
44579231 188346 0 None -1 3 Human 7.8 pKi = 7.8 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 396 6 1 6 1.7 O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1 10.1016/j.bmcl.2008.08.055
CHEMBL476774 188346 0 None -1 3 Human 7.8 pKi = 7.8 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 396 6 1 6 1.7 O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1 10.1016/j.bmcl.2008.08.055
10070896 89971 0 None -338 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 422 4 1 4 6.1 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1-c1ccccc1 10.1021/jm060262x
CHEMBL218457 89971 0 None -338 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 422 4 1 4 6.1 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1-c1ccccc1 10.1021/jm060262x
26757 214757 31 None 1 2 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 187 4 0 1 2.2 C#CCN(C)[C@H](C)Cc1ccccc1 nan
CHEMBL972 214757 31 None 1 2 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 187 4 0 1 2.2 C#CCN(C)[C@H](C)Cc1ccccc1 nan
155545843 180260 0 None -13 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 399 3 2 5 4.7 Clc1cccc(CNc2nc(C#Cc3ccc(Cl)s3)nc3[nH]cnc23)c1 10.1039/C8MD00317C
CHEMBL4530091 180260 0 None -13 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 399 3 2 5 4.7 Clc1cccc(CNc2nc(C#Cc3ccc(Cl)s3)nc3[nH]cnc23)c1 10.1039/C8MD00317C
44312037 211398 1 None -1 6 Human 4.8 pKi = 4.8 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 308 1 1 5 2.9 Brc1c(NC2=NCCS2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL73392 211398 1 None -1 6 Human 4.8 pKi = 4.8 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 308 1 1 5 2.9 Brc1c(NC2=NCCS2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
100 10577 58 None -35 54 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
2637 10577 58 None -35 54 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
5452 10577 58 None -35 54 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
CHEMBL479 10577 58 None -35 54 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
DB00679 10577 58 None -35 54 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
10475736 172642 0 None -34 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 394 4 2 5 4.1 CN1CCN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CC1(C)C 10.1021/jm060262x
CHEMBL424917 172642 0 None -34 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 394 4 2 5 4.1 CN1CCN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CC1(C)C 10.1021/jm060262x
2247 7293 81 None -57 42 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 7293 81 None -57 42 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 7293 81 None -57 42 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 7293 81 None -57 42 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 7293 81 None -57 42 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2541 7573 120 None -2691 6 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
587 7573 120 None -2691 6 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
6907 7573 120 None -2691 6 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
CHEMBL1016 7573 120 None -2691 6 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
DB00796 7573 120 None -2691 6 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
DB13919 7573 120 None -2691 6 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O nan
44288877 175378 0 None -251 5 Human 5.8 pKi = 5.8 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 549 7 1 5 4.3 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
CHEMBL43594 175378 0 None -251 5 Human 5.8 pKi = 5.8 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 549 7 1 5 4.3 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
16090632 148494 0 None -87 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 348 4 3 5 3.3 C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1 10.1021/jm060262x
CHEMBL385722 148494 0 None -87 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 348 4 3 5 3.3 C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1 10.1021/jm060262x
213 10625 55 None -3 43 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
2717 10625 55 None -3 43 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
5533 10625 55 None -3 43 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
CHEMBL621 10625 55 None -3 43 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
DB00656 10625 55 None -3 43 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
114697 10459 4 None 1 3 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 263 1 2 3 2.7 Clc1ccc(cc1NC1=NCCN1)C(F)(F)F 10.1021/jm00020a021
513 10459 4 None 1 3 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 263 1 2 3 2.7 Clc1ccc(cc1NC1=NCCN1)C(F)(F)F 10.1021/jm00020a021
CHEMBL101340 10459 4 None 1 3 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 263 1 2 3 2.7 Clc1ccc(cc1NC1=NCCN1)C(F)(F)F 10.1021/jm00020a021
9883506 77339 0 None -1 6 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 282 3 3 5 2.3 Cc1ccc(N(NC2=NCCN2)c2cccc(O)c2)cc1 10.1016/j.bmcl.2005.07.083
CHEMBL194849 77339 0 None -1 6 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 282 3 3 5 2.3 Cc1ccc(N(NC2=NCCN2)c2cccc(O)c2)cc1 10.1016/j.bmcl.2005.07.083
44371848 20397 0 None -15 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 845 15 6 6 8.1 O=C(NCCCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL1194334 20397 0 None -15 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 845 15 6 6 8.1 O=C(NCCCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL551711 20397 0 None -15 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 845 15 6 6 8.1 O=C(NCCCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
10056237 20516 0 None -47 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 817 13 6 6 7.3 O=C(NCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL1195197 20516 0 None -47 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 817 13 6 6 7.3 O=C(NCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL554019 20516 0 None -47 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 817 13 6 6 7.3 O=C(NCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
16090601 89167 0 None -199 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 376 4 2 5 3.9 Cc1c(CO)nc2ccccc2c1Nc1ccc(N2CCN(C)[C@H](C)C2)cc1 10.1021/jm060262x
CHEMBL217254 89167 0 None -199 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 376 4 2 5 3.9 Cc1c(CO)nc2ccccc2c1Nc1ccc(N2CCN(C)[C@H](C)C2)cc1 10.1021/jm060262x
6075 156887 42 None -6 16 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 nan
CHEMBL395110 156887 42 None -6 16 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 nan
44371755 55551 0 None -15 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 218 3 1 3 2.1 Cc1cccc(C)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL155866 55551 0 None -15 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 218 3 1 3 2.1 Cc1cccc(C)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
10508132 113794 0 None -30 6 Human 5.7 pKi = 5.7 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 621 10 2 6 5.5 CC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)N(C)C)=C(C)N1 10.1021/jm980077m
CHEMBL315392 113794 0 None -30 6 Human 5.7 pKi = 5.7 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 621 10 2 6 5.5 CC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)N(C)C)=C(C)N1 10.1021/jm980077m
44311789 211514 0 None -1 5 Human 4.7 pKi = 4.7 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 345 1 2 5 3.1 Brc1c(NC2=N[C@@H]3CCCC[C@@H]3N2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL74342 211514 0 None -1 5 Human 4.7 pKi = 4.7 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 345 1 2 5 3.1 Brc1c(NC2=N[C@@H]3CCCC[C@@H]3N2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL4566600 220793 0 None 1 6 Human 5.7 pKi = 5.7 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl ADRA2B
ChEMBL None None None Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 10.6019/CHEMBL5212743
CHEMBL4745071 220793 0 None 1 6 Human 5.7 pKi = 5.7 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl ADRA2B
ChEMBL None None None Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 10.6019/CHEMBL5212743
9879119 16218 0 None -8 5 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 291 4 2 3 2.2 CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL111771 16218 0 None -8 5 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 291 4 2 3 2.2 CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1 10.1021/jm030551a
43260 12254 65 None -1 5 Rat 5.7 pKi = 5.7 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1021/jm030551a
CHEMBL1076 12254 65 None -1 5 Rat 5.7 pKi = 5.7 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1021/jm030551a
12114851 19813 0 None -12 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 732 7 6 6 5.0 O=C(NCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL1189965 19813 0 None -12 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 732 7 6 6 5.0 O=C(NCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL539824 19813 0 None -12 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 732 7 6 6 5.0 O=C(NCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
23622576 179551 0 None -2 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 272 4 1 3 3.5 CC(Oc1ccccc1C1CCCCC1)C1=NCCN1 10.1021/jm800250z
CHEMBL451229 179551 0 None -2 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 272 4 1 3 3.5 CC(Oc1ccccc1C1CCCCC1)C1=NCCN1 10.1021/jm800250z
24906199 194444 15 None -7 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 258 4 1 3 3.1 CC(Oc1ccccc1C1CCCC1)C1=NCCN1 10.1021/jm800250z
CHEMBL495096 194444 15 None -7 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 258 4 1 3 3.1 CC(Oc1ccccc1C1CCCC1)C1=NCCN1 10.1021/jm800250z
CHEMBL5274312 200588 0 None -1 5 Human 5.7 pKi = 5.7 Binding
Binding affinity to adrenergic alpha 2b receptor (unknown origin)Binding affinity to adrenergic alpha 2b receptor (unknown origin)
ChEMBL 383 4 0 3 5.0 CC[Si](C#Cc1cccc2c1OC(C(F)(F)F)C([N+](=O)[O-])=C2)(CC)CC 10.1016/j.bmcl.2022.128981
10474679 103952 0 None -295 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 376 4 2 5 4.0 CN1CCN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CC1(C)C 10.1021/jm060262x
CHEMBL268217 103952 0 None -295 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 376 4 2 5 4.0 CN1CCN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CC1(C)C 10.1021/jm060262x
135398745 9688 112 None -37 65 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
47 9688 112 None -37 65 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
CHEMBL715 9688 112 None -37 65 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
DB00334 9688 112 None -37 65 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
44579184 197732 4 None -2 3 Human 6.7 pKi = 6.7 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 340 4 0 5 2.7 COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
CHEMBL518592 197732 4 None -2 3 Human 6.7 pKi = 6.7 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 340 4 0 5 2.7 COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
3584 10549 64 None -21 14 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
5401 10549 64 None -21 14 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
7302 10549 64 None -21 14 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
CHEMBL611 10549 64 None -21 14 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
DB01162 10549 64 None -21 14 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
10579368 112781 0 None 1 6 Human 6.7 pKi = 6.7 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 593 9 3 6 5.3 CC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL313251 112781 0 None 1 6 Human 6.7 pKi = 6.7 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 593 9 3 6 5.3 CC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
75306277 116031 0 None -99 23 Human 6.7 pKi = 6.7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 10.1039/C2MD00311B
CHEMBL3217984 116031 0 None -99 23 Human 6.7 pKi = 6.7 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 10.1039/C2MD00311B
44421258 91521 0 None -3 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 264 3 1 3 2.8 c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1 10.1021/jm0408215
CHEMBL1204386 91521 0 None -3 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 264 3 1 3 2.8 c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1 10.1021/jm0408215
CHEMBL222933 91521 0 None -3 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 264 3 1 3 2.8 c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1 10.1021/jm0408215
44324937 213692 0 None -2 3 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 389 5 0 5 3.1 C(=C/c1ccccc1)\CN1CCN(CC2ON=C3c4ccccc4OCC32)CC1 10.1016/s0960-894x(03)00525-0
CHEMBL90943 213692 0 None -2 3 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 389 5 0 5 3.1 C(=C/c1ccccc1)\CN1CCN(CC2ON=C3c4ccccc4OCC32)CC1 10.1016/s0960-894x(03)00525-0
102 10899 48 None -10 49 Rat 8.7 pKi = 8.7 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm990277d
3659 10899 48 None -10 49 Rat 8.7 pKi = 8.7 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm990277d
8969 10899 48 None -10 49 Rat 8.7 pKi = 8.7 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm990277d
CHEMBL15245 10899 48 None -10 49 Rat 8.7 pKi = 8.7 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm990277d
DB01392 10899 48 None -10 49 Rat 8.7 pKi = 8.7 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm990277d
102 10899 48 None -10 49 Human 8.7 pKi = 8.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/s0960-894x(00)00068-8
3659 10899 48 None -10 49 Human 8.7 pKi = 8.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/s0960-894x(00)00068-8
8969 10899 48 None -10 49 Human 8.7 pKi = 8.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/s0960-894x(00)00068-8
CHEMBL15245 10899 48 None -10 49 Human 8.7 pKi = 8.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/s0960-894x(00)00068-8
DB01392 10899 48 None -10 49 Human 8.7 pKi = 8.7 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/s0960-894x(00)00068-8
218362 211579 5 None 1 4 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 216 1 1 3 2.0 c1ccc2c(c1)CCCC2NC1=NCCO1 10.1016/0960-894X(94)85032-1
CHEMBL75030 211579 5 None 1 4 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 216 1 1 3 2.0 c1ccc2c(c1)CCCC2NC1=NCCO1 10.1016/0960-894X(94)85032-1
12576 7302 94 None -7 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 10.1021/jm1006269
71310 7302 94 None -7 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 10.1021/jm1006269
CHEMBL353972 7302 94 None -7 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 10.1021/jm1006269
DB11481 7302 94 None -7 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 10.1021/jm1006269
49781224 23915 0 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 238 3 1 1 3.7 CCC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1255616 23915 0 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 238 3 1 1 3.7 CCC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
49781005 23986 0 None -3 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 226 2 1 2 2.5 CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1256503 23986 0 None -3 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 226 2 1 2 2.5 CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
9837600 30092 0 None -12 2 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 236 0 1 3 1.9 NC1=NC2(CCc3cccc(Cl)c3C2)CO1 10.1021/jm00020a021
CHEMBL133231 30092 0 None -12 2 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 236 0 1 3 1.9 NC1=NC2(CCc3cccc(Cl)c3C2)CO1 10.1021/jm00020a021
16090625 89205 0 None -23 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 3 1 4 5.0 Cc1nc2cccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
CHEMBL217452 89205 0 None -23 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 3 1 4 5.0 Cc1nc2cccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
10651080 112719 0 None -23 6 Human 6.7 pKi = 6.7 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 592 9 3 6 4.7 CC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL312871 112719 0 None -23 6 Human 6.7 pKi = 6.7 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 592 9 3 6 4.7 CC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
9817231 165015 22 None -2 7 Human 4.7 pKi = 4.7 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 282 4 0 3 4.1 CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1 10.1038/s41586-020-2286-9
CHEMBL4088272 165015 22 None -2 7 Human 4.7 pKi = 4.7 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 282 4 0 3 4.1 CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1 10.1038/s41586-020-2286-9
44438165 173563 0 None -223 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 467 9 1 7 3.3 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL428407 173563 0 None -223 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 467 9 1 7 3.3 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2 10.1016/j.bmcl.2006.12.094
57402718 77964 2 None -1 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 218 4 1 4 1.3 CC(Oc1ccccc1C=O)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956201 77964 2 None -1 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 218 4 1 4 1.3 CC(Oc1ccccc1C=O)C1=NCCN1 10.1016/j.bmc.2012.01.035
16655023 114218 2 None -5 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
CHEMBL318235 114218 2 None -5 7 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
150 9287 21 None -27 16 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO nan
1764 9287 21 None -27 16 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO nan
8226 9287 21 None -27 16 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO nan
CHEMBL1201356 9287 21 None -27 16 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO nan
DB00353 9287 21 None -27 16 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO nan
1210 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
1213 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
2725 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
33036 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
4411 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
616 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
6976 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
716121 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL1201353 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL1554789 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL505 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
DB01114 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
DB13679 7705 51 None -234 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
11360447 91776 0 None -12 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 272 4 1 4 3.2 CC(Oc1ccccc1-c1cccs1)C1=NCCN1 10.1021/jm0408215
CHEMBL223829 91776 0 None -12 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 272 4 1 4 3.2 CC(Oc1ccccc1-c1cccs1)C1=NCCN1 10.1021/jm0408215
134 9292 24 None -93 67 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO nan
1775 9292 24 None -93 67 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO nan
9681 9292 24 None -93 67 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO nan
CHEMBL1065 9292 24 None -93 67 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO nan
DB00247 9292 24 None -93 67 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO nan
9828476 213703 0 None -954 6 Human 6.7 pKi = 6.7 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 532 9 2 7 5.2 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL91022 213703 0 None -954 6 Human 6.7 pKi = 6.7 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 532 9 2 7 5.2 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
10198248 194228 40 None 1 6 Human 6.7 pKi = 6.7 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 213 1 2 5 1.0 c1cnc2cc(NC3=NCCN3)ccc2n1 10.1016/0960-894X(95)00391-6
CHEMBL49395 194228 40 None 1 6 Human 6.7 pKi = 6.7 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 213 1 2 5 1.0 c1cnc2cc(NC3=NCCN3)ccc2n1 10.1016/0960-894X(95)00391-6
127026052 144331 0 None -13 19 Human 6.7 pKi = 6.7 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 258 7 1 1 3.5 C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL3754496 144331 0 None -13 19 Human 6.7 pKi = 6.7 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 258 7 1 1 3.5 C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12 10.1016/j.bmcl.2015.12.053
73213195 111236 0 None -75 12 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.6 CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104092 111236 0 None -75 12 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.6 CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 10.1016/j.bmcl.2013.12.024
73213195 111236 0 None -75 12 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.6 CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104092 111236 0 None -75 12 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.6 CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 10.1016/j.bmcl.2013.12.024
11347303 118157 0 None 1 5 Rat 7.7 pKi = 7.7 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1ccc2c(c1)C(c1c[nH]cn1)CCC2 10.1021/jm030551a
CHEMBL327116 118157 0 None 1 5 Rat 7.7 pKi = 7.7 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1ccc2c(c1)C(c1c[nH]cn1)CCC2 10.1021/jm030551a
44292381 108171 0 None -1 3 Human 7.7 pKi = 7.7 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 244 2 1 3 2.7 c1ccc([C@H]2CCCC[C@@H]2NC2=NCCO2)cc1 10.1021/jm9905256
CHEMBL297228 108171 0 None -1 3 Human 7.7 pKi = 7.7 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 244 2 1 3 2.7 c1ccc([C@H]2CCCC[C@@H]2NC2=NCCO2)cc1 10.1021/jm9905256
12575 8769 30 None -53 17 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1021/jm800250z
54459 8769 30 None -53 17 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1021/jm800250z
CHEMBL10316 8769 30 None -53 17 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1021/jm800250z
12575 8769 30 None -53 17 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1016/j.bmc.2012.02.016
54459 8769 30 None -53 17 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1016/j.bmc.2012.02.016
CHEMBL10316 8769 30 None -53 17 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 10.1016/j.bmc.2012.02.016
9795515 211599 0 None -44 3 Rat 6.7 pKi = 6.7 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 273 3 2 3 4.1 COc1c(C(C)(C)C)cc(C)c(Nc2ncc[nH]2)c1C 10.1021/jm9605142
CHEMBL75257 211599 0 None -44 3 Rat 6.7 pKi = 6.7 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 273 3 2 3 4.1 COc1c(C(C)(C)C)cc(C)c(Nc2ncc[nH]2)c1C 10.1021/jm9605142
132060776 169181 0 None -7 16 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 419 4 0 4 4.4 O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1 10.1016/j.ejmech.2018.02.024
CHEMBL4165863 169181 0 None -7 16 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 419 4 0 4 4.4 O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1 10.1016/j.ejmech.2018.02.024
15853467 214913 0 None -69 6 Human 6.6 pKi = 6.6 Binding
Binding affinity against human Alpha-2B adrenergic receptorBinding affinity against human Alpha-2B adrenergic receptor
ChEMBL 692 16 3 8 5.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN=[N+]=[N-])N1 10.1016/s0960-894x(99)00484-9
CHEMBL98063 214913 0 None -69 6 Human 6.6 pKi = 6.6 Binding
Binding affinity against human Alpha-2B adrenergic receptorBinding affinity against human Alpha-2B adrenergic receptor
ChEMBL 692 16 3 8 5.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN=[N+]=[N-])N1 10.1016/s0960-894x(99)00484-9
127036953 144293 0 None -22 22 Human 6.6 pKi = 6.6 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 318 7 1 1 4.1 C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL3754166 144293 0 None -22 22 Human 6.6 pKi = 6.6 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 318 7 1 1 4.1 C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 10.1016/j.bmcl.2015.12.053
10793665 113729 0 None -1288 6 Human 5.6 pKi = 5.6 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 597 9 2 5 7.2 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)cc1 10.1021/jm980077m
CHEMBL314960 113729 0 None -1288 6 Human 5.6 pKi = 5.6 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 597 9 2 5 7.2 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)cc1 10.1021/jm980077m
10220053 213699 0 None -3 3 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 218 2 1 2 1.9 Fc1ccc2c(c1)CC(CC1CN=CN1)C2 10.1016/s0960-894x(03)00525-0
CHEMBL90997 213699 0 None -3 3 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 218 2 1 2 1.9 Fc1ccc2c(c1)CC(CC1CN=CN1)C2 10.1016/s0960-894x(03)00525-0
10220053 213699 0 None -3 3 Human 7.6 pKi = 7.6 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 218 2 1 2 1.9 Fc1ccc2c(c1)CC(CC1CN=CN1)C2 10.1021/jm049619s
CHEMBL90997 213699 0 None -3 3 Human 7.6 pKi = 7.6 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 218 2 1 2 1.9 Fc1ccc2c(c1)CC(CC1CN=CN1)C2 10.1021/jm049619s
49781004 23985 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 226 2 1 2 2.5 CO[C@@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1 10.1021/jm1006269
CHEMBL1256502 23985 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 226 2 1 2 2.5 CO[C@@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1 10.1021/jm1006269
10859076 20454 0 None -40 6 Human 5.6 pKi = 5.6 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL1194763 20454 0 None -40 6 Human 5.6 pKi = 5.6 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL553276 20454 0 None -40 6 Human 5.6 pKi = 5.6 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1 10.1021/jm000542r
44329026 215204 0 None -46 6 Human 6.6 pKi = 6.6 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 679 16 3 7 6.1 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCOC)N1 10.1016/s0960-894x(99)00484-9
CHEMBL99864 215204 0 None -46 6 Human 6.6 pKi = 6.6 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 679 16 3 7 6.1 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCOC)N1 10.1016/s0960-894x(99)00484-9
21830793 98610 10 None -1584 46 Human 6.6 pKi = 6.6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin)Binding affinity to adrenergic alpha2B receptor (unknown origin)
ChEMBL 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 10.1016/j.bmc.2013.05.050
CHEMBL2413154 98610 10 None -1584 46 Human 6.6 pKi = 6.6 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin)Binding affinity to adrenergic alpha2B receptor (unknown origin)
ChEMBL 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 10.1016/j.bmc.2013.05.050
135 9310 43 None -8 56 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
1796 9310 43 None -8 56 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
4184 9310 43 None -8 56 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
CHEMBL6437 9310 43 None -8 56 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
DB06148 9310 43 None -8 56 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
2286 9957 51 None -4 30 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
4927 9957 51 None -4 30 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
7282 9957 51 None -4 30 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
CHEMBL643 9957 51 None -4 30 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
DB01069 9957 51 None -4 30 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
44456400 19606 0 None 1 10 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL1188501 19606 0 None 1 10 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL2436555 19606 0 None 1 10 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL536539 19606 0 None 1 10 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
132060763 169640 0 None -9 8 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 405 5 0 4 4.1 C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 10.1016/j.ejmech.2018.02.024
CHEMBL4173095 169640 0 None -9 8 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 405 5 0 4 4.1 C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 10.1016/j.ejmech.2018.02.024
4038180 6992 14 None -23 8 Rat 6.6 pKi = 6.6 Binding
Binding affinity to Rattus norvegicus (rat) alpha2B receptor isolated from neonatal lungBinding affinity to Rattus norvegicus (rat) alpha2B receptor isolated from neonatal lung
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
480 6992 14 None -23 8 Rat 6.6 pKi = 6.6 Binding
Binding affinity to Rattus norvegicus (rat) alpha2B receptor isolated from neonatal lungBinding affinity to Rattus norvegicus (rat) alpha2B receptor isolated from neonatal lung
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
CHEMBL109783 6992 14 None -23 8 Rat 6.6 pKi = 6.6 Binding
Binding affinity to Rattus norvegicus (rat) alpha2B receptor isolated from neonatal lungBinding affinity to Rattus norvegicus (rat) alpha2B receptor isolated from neonatal lung
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
44456400 19606 0 None 1 10 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL1188501 19606 0 None 1 10 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL2436555 19606 0 None 1 10 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
CHEMBL536539 19606 0 None 1 10 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2B-adrenoceptor expressed in HEK cells after 90 mins by scintillation counting analysis
ChEMBL 181 0 2 3 1.4 NC1=Nc2ccc(Cl)cc2CN1 10.1016/j.bmcl.2013.08.072
4038180 6992 14 None -23 8 Rat 6.6 pKi = 6.6 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm030551a
480 6992 14 None -23 8 Rat 6.6 pKi = 6.6 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm030551a
CHEMBL109783 6992 14 None -23 8 Rat 6.6 pKi = 6.6 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm030551a
10660 21188 58 None -67 12 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 469 6 1 7 3.0 CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O nan
CHEMBL1200406 21188 58 None -67 12 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 469 6 1 7 3.0 CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O nan
44424855 92229 0 None -1 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 467 7 0 7 3.3 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2 10.1016/j.bmc.2007.03.053
CHEMBL226636 92229 0 None -1 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 467 7 0 7 3.3 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2 10.1016/j.bmc.2007.03.053
44314200 109729 0 None 1 4 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 230 1 1 3 2.4 c1ccc2c(c1)CCCC2NC1=NCCCO1 10.1016/0960-894X(94)85032-1
CHEMBL306377 109729 0 None 1 4 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 230 1 1 3 2.4 c1ccc2c(c1)CCCC2NC1=NCCCO1 10.1016/0960-894X(94)85032-1
16090599 88320 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 360 3 1 4 5.0 Cc1nc2c(C)cccc2c(Nc2ccc(N3CCCN(C)C3)cc2)c1C 10.1021/jm060262x
CHEMBL216072 88320 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 360 3 1 4 5.0 Cc1nc2c(C)cccc2c(Nc2ccc(N3CCCN(C)C3)cc2)c1C 10.1021/jm060262x
10609673 110553 0 None -19 3 Rat 5.6 pKi = 5.6 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 233 4 2 4 2.5 COc1ccc(Nc2ncc[nH]2)c(C)c1OC 10.1021/jm9605142
CHEMBL308863 110553 0 None -19 3 Rat 5.6 pKi = 5.6 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 233 4 2 4 2.5 COc1ccc(Nc2ncc[nH]2)c(C)c1OC 10.1021/jm9605142
3561 25849 39 None -1 11 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
CHEMBL1289 25849 39 None -1 11 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
250 10159 8 None -70794 13 Human 5.6 pKi = 5.6 Binding
Compound was evaluated for binding affinity against Alpha-2B adrenergic receptor using radioligand binding assayCompound was evaluated for binding affinity against Alpha-2B adrenergic receptor using radioligand binding assay
ChEMBL 502 10 1 7 5.0 COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC 10.1016/0960-894X(95)00358-Z
5311416 10159 8 None -70794 13 Human 5.6 pKi = 5.6 Binding
Compound was evaluated for binding affinity against Alpha-2B adrenergic receptor using radioligand binding assayCompound was evaluated for binding affinity against Alpha-2B adrenergic receptor using radioligand binding assay
ChEMBL 502 10 1 7 5.0 COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC 10.1016/0960-894X(95)00358-Z
CHEMBL69733 10159 8 None -70794 13 Human 5.6 pKi = 5.6 Binding
Compound was evaluated for binding affinity against Alpha-2B adrenergic receptor using radioligand binding assayCompound was evaluated for binding affinity against Alpha-2B adrenergic receptor using radioligand binding assay
ChEMBL 502 10 1 7 5.0 COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC 10.1016/0960-894X(95)00358-Z
10337773 108362 0 None -63 10 Human 4.6 pKi = 4.6 Binding
Binding affinity against Alpha-2B adrenergic receptorBinding affinity against Alpha-2B adrenergic receptor
ChEMBL 311 3 1 4 1.6 Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21 10.1016/0960-894X(95)00308-G
CHEMBL298612 108362 0 None -63 10 Human 4.6 pKi = 4.6 Binding
Binding affinity against Alpha-2B adrenergic receptorBinding affinity against Alpha-2B adrenergic receptor
ChEMBL 311 3 1 4 1.6 Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21 10.1016/0960-894X(95)00308-G
181743 185351 5 None -125 22 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]Clonidine from human adrenergic alpha2B receptorDisplacement of [3H]Clonidine from human adrenergic alpha2B receptor
ChEMBL 339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 10.1016/j.bmcl.2009.11.053
CHEMBL467094 185351 5 None -125 22 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]Clonidine from human adrenergic alpha2B receptorDisplacement of [3H]Clonidine from human adrenergic alpha2B receptor
ChEMBL 339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 10.1016/j.bmcl.2009.11.053
135559170 108837 0 None -389 7 Human 6.6 pKi = 6.6 Binding
Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin
ChEMBL 391 4 1 5 2.5 COc1ccccc1N1CCN(CC2CN3C(=O)Nc4ccccc4C3=N2)CC1 10.1021/jm970159v
CHEMBL302021 108837 0 None -389 7 Human 6.6 pKi = 6.6 Binding
Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin
ChEMBL 391 4 1 5 2.5 COc1ccccc1N1CCN(CC2CN3C(=O)Nc4ccccc4C3=N2)CC1 10.1021/jm970159v
73352414 99307 0 None -3 5 Human 5.6 pKi = 5.6 Binding
Inhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 257 3 1 1 3.3 C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1 10.1016/j.bmc.2013.07.045
CHEMBL2432038 99307 0 None -3 5 Human 5.6 pKi = 5.6 Binding
Inhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 257 3 1 1 3.3 C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1 10.1016/j.bmc.2013.07.045
136680384 214434 0 None -575 6 Human 5.6 pKi = 5.6 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 694 16 4 8 4.9 CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
44328799 214434 0 None -575 6 Human 5.6 pKi = 5.6 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 694 16 4 8 4.9 CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
CHEMBL95290 214434 0 None -575 6 Human 5.6 pKi = 5.6 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 694 16 4 8 4.9 CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
191 7191 98 None -30 29 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
201 7191 98 None -30 29 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
2170 7191 98 None -30 29 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
CHEMBL1113 7191 98 None -30 29 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
DB00543 7191 98 None -30 29 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
9895326 213806 0 None -239 6 Human 6.6 pKi = 6.6 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 621 12 3 6 5.7 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CC)N1 10.1021/jm980077m
CHEMBL91550 213806 0 None -239 6 Human 6.6 pKi = 6.6 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 621 12 3 6 5.7 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CC)N1 10.1021/jm980077m
CHEMBL4778870 220826 8 None -7 5 Human 5.6 pKi = 5.6 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None CC1CCN(c2ccnc(NCc3cn(C)cn3)n2)CC1 10.6019/CHEMBL4800732
CHEMBL4778870 220826 8 None -7 5 Human 5.6 pKi = 5.6 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None CC1CCN(c2ccnc(NCc3cn(C)cn3)n2)CC1 10.6019/CHEMBL4800732
3584 10549 64 None -21 14 Human 7.6 pKi = 7.6 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00010a001
5401 10549 64 None -21 14 Human 7.6 pKi = 7.6 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00010a001
7302 10549 64 None -21 14 Human 7.6 pKi = 7.6 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00010a001
CHEMBL611 10549 64 None -21 14 Human 7.6 pKi = 7.6 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00010a001
DB01162 10549 64 None -21 14 Human 7.6 pKi = 7.6 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00010a001
136019934 151308 0 None -12 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 462 7 1 7 3.6 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2 10.1016/j.bmc.2007.03.053
CHEMBL390718 151308 0 None -12 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 462 7 1 7 3.6 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2 10.1016/j.bmc.2007.03.053
16090624 89176 0 None -34 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 3 1 4 5.0 Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1 10.1021/jm060262x
CHEMBL217278 89176 0 None -34 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 3 1 4 5.0 Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1 10.1021/jm060262x
16090602 89223 0 None -288 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 362 4 2 5 3.6 C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1C 10.1021/jm060262x
CHEMBL217542 89223 0 None -288 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 362 4 2 5 3.6 C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1C 10.1021/jm060262x
16090628 148565 0 None -309 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 4 1 4 5.3 CCc1c(C)nc2c(C)cccc2c1Nc1ccc(N2CCCN(C)CC2)cc1 10.1021/jm060262x
CHEMBL386169 148565 0 None -309 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 4 1 4 5.3 CCc1c(C)nc2c(C)cccc2c1Nc1ccc(N2CCCN(C)CC2)cc1 10.1021/jm060262x
49836303 25344 1 None -43 4 Human 6.6 pKi = 6.6 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 4 1 3 2.3 C[C@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL1276220 25344 1 None -43 4 Human 6.6 pKi = 6.6 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 4 1 3 2.3 C[C@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/ml400232p
49836303 25344 1 None -43 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 4 1 3 2.3 C[C@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/jm100977d
CHEMBL1276220 25344 1 None -43 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 4 1 3 2.3 C[C@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/jm100977d
162265 209053 22 None 5 44 Rat 6.6 pKi = 6.6 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1021/jm030551a
4786 209053 22 None 5 44 Rat 6.6 pKi = 6.6 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1021/jm030551a
CHEMBL61006 209053 22 None 5 44 Rat 6.6 pKi = 6.6 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1021/jm030551a
3198 212292 76 None -24 34 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 212292 76 None -24 34 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 212292 76 None -24 34 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44371864 57915 0 None -8 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 246 5 1 3 2.6 CCc1cccc(CC)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL157955 57915 0 None -8 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 246 5 1 3 2.6 CCc1cccc(CC)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
11211035 91778 0 None -18 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 284 4 1 3 3.3 CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1 10.1021/jm061487a
CHEMBL223836 91778 0 None -18 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 284 4 1 3 3.3 CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1 10.1021/jm061487a
11211035 91778 0 None -18 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 284 4 1 3 3.3 CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1 10.1021/jm0408215
CHEMBL223836 91778 0 None -18 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 284 4 1 3 3.3 CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1 10.1021/jm0408215
45487089 204419 0 None -10 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 204 2 1 3 2.0 Cc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
CHEMBL570863 204419 0 None -10 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 204 2 1 3 2.0 Cc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
11380133 176146 0 None -9 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1ccncc1)C1=NCCN1 10.1021/jm0408215
CHEMBL442045 176146 0 None -9 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1ccncc1)C1=NCCN1 10.1021/jm0408215
3080926 162374 21 None -10 3 Human 4.6 pKi = 4.6 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 186 1 1 3 1.8 c1ccc2oc(C3=NCCN3)cc2c1 10.1021/ml400232p
CHEMBL404505 162374 21 None -10 3 Human 4.6 pKi = 4.6 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 186 1 1 3 1.8 c1ccc2oc(C3=NCCN3)cc2c1 10.1021/ml400232p
12114852 20092 0 None -31 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 774 10 6 6 6.1 O=C(NCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL1192051 20092 0 None -31 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 774 10 6 6 6.1 O=C(NCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL543232 20092 0 None -31 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 774 10 6 6 6.1 O=C(NCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
2353 107889 82 None 1 5 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 336 2 0 4 3.1 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 nan
CHEMBL12089 107889 82 None 1 5 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 336 2 0 4 3.1 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 nan
CHEMBL295124 107889 82 None 1 5 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 336 2 0 4 3.1 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 nan
10176433 27420 0 None -8 2 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 186 0 1 2 1.5 C1=NCC2(CCc3ccccc3C2)N1 10.1021/jm00020a021
CHEMBL130853 27420 0 None -8 2 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 186 0 1 2 1.5 C1=NCC2(CCc3ccccc3C2)N1 10.1021/jm00020a021
9894818 105701 0 None -125 7 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm00019a001
CHEMBL279436 105701 0 None -125 7 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm00019a001
44371744 57095 0 None -16 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 270 7 1 3 2.9 C=CCc1cccc(CC=C)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL157206 57095 0 None -16 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 270 7 1 3 2.9 C=CCc1cccc(CC=C)c1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
499 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm00018a001
5685 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm00018a001
CHEMBL25554 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm00018a001
44579228 188433 0 None -13 3 Human 7.6 pKi = 7.6 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 467 7 2 7 2.9 CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
CHEMBL477608 188433 0 None -13 3 Human 7.6 pKi = 7.6 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 467 7 2 7 2.9 CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1 10.1016/j.bmcl.2008.08.055
102 10899 48 None -10 49 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2013.12.024
3659 10899 48 None -10 49 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2013.12.024
8969 10899 48 None -10 49 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2013.12.024
CHEMBL15245 10899 48 None -10 49 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2013.12.024
DB01392 10899 48 None -10 49 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2013.12.024
9894818 105701 0 None -125 7 Human 6.6 pKi = 6.6 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL279436 105701 0 None -125 7 Human 6.6 pKi = 6.6 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
44371745 56063 0 None -11 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 218 4 1 3 2.0 CCc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL156336 56063 0 None -11 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 218 4 1 3 2.0 CCc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
70696790 83074 0 None 1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 194 3 1 3 1.5 CC1COC(NC(C2CC2)C2CC2)=N1 10.1016/j.bmc.2012.06.008
CHEMBL2058632 83074 0 None 1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 194 3 1 3 1.5 CC1COC(NC(C2CC2)C2CC2)=N1 10.1016/j.bmc.2012.06.008
57403508 78027 0 None 2 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 308 3 1 4 2.3 c1ccc(C2(c3ccccc3)COC(C3=NCCN3)CO2)cc1 10.1016/j.bmc.2012.02.016
CHEMBL1956905 78027 0 None 2 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 308 3 1 4 2.3 c1ccc(C2(c3ccccc3)COC(C3=NCCN3)CO2)cc1 10.1016/j.bmc.2012.02.016
44329027 10940 0 None -14 6 Human 6.5 pKi = 6.5 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 637 13 3 7 4.9 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COC)N1 10.1016/s0960-894x(99)00484-9
CHEMBL100045 10940 0 None -14 6 Human 6.5 pKi = 6.5 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 637 13 3 7 4.9 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COC)N1 10.1016/s0960-894x(99)00484-9
10436842 107032 0 None -363 7 Human 6.5 pKi = 6.5 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 524 7 1 4 4.6 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
CHEMBL288772 107032 0 None -363 7 Human 6.5 pKi = 6.5 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 524 7 1 4 4.6 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
2105 9828 37 None -8 32 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
47811 9828 37 None -8 32 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
48 9828 37 None -8 32 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
CHEMBL531 9828 37 None -8 32 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
DB01186 9828 37 None -8 32 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
127035062 143229 0 None 3 19 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]Rauwolscine from human recombinant alpha 2B receptor expressed in HEKT cells after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human recombinant alpha 2B receptor expressed in HEKT cells after 90 mins by scintillation counting method
ChEMBL 447 12 0 5 5.2 COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC 10.1039/C4MD00418C
CHEMBL3735756 143229 0 None 3 19 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]Rauwolscine from human recombinant alpha 2B receptor expressed in HEKT cells after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human recombinant alpha 2B receptor expressed in HEKT cells after 90 mins by scintillation counting method
ChEMBL 447 12 0 5 5.2 COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC 10.1039/C4MD00418C
16090627 88342 0 None -35 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 390 9 2 4 5.9 CCc1c(C)nc2c(C)cccc2c1Nc1ccc(NCCN(CC)CC)cc1 10.1021/jm060262x
CHEMBL216197 88342 0 None -35 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 390 9 2 4 5.9 CCc1c(C)nc2c(C)cccc2c1Nc1ccc(NCCN(CC)CC)cc1 10.1021/jm060262x
2335 18620 22 None -2 12 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
8478 18620 22 None -2 12 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL1182210 18620 22 None -2 12 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL221753 18620 22 None -2 12 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
16090635 89290 0 None -26 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 378 4 1 4 4.7 CCc1c(C)nc2c(c1Nc1ccc(N3CCN(C)C(C)C3)cc1)CCCC2 10.1021/jm060262x
CHEMBL217768 89290 0 None -26 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 378 4 1 4 4.7 CCc1c(C)nc2c(c1Nc1ccc(N3CCN(C)C(C)C3)cc1)CCCC2 10.1021/jm060262x
132075278 169423 0 None -52 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 308 3 0 3 3.1 c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1 10.1016/j.ejmech.2018.02.024
CHEMBL4169752 169423 0 None -52 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 308 3 0 3 3.1 c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1 10.1016/j.ejmech.2018.02.024
11293787 154992 0 None -27 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 447 6 0 5 5.8 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL393597 154992 0 None -27 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 447 6 0 5 5.8 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2 10.1016/j.bmcl.2006.12.094
44324800 213727 0 None -22 7 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL91157 213727 0 None -22 7 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
44324800 213727 0 None -22 7 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2 10.1021/jm049619s
CHEMBL91157 213727 0 None -22 7 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptor
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2 10.1021/jm049619s
102 10899 48 None -10 49 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2013.12.024
3659 10899 48 None -10 49 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2013.12.024
8969 10899 48 None -10 49 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2013.12.024
CHEMBL15245 10899 48 None -10 49 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2013.12.024
DB01392 10899 48 None -10 49 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2013.12.024
126225 101751 5 None -1 7 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 263 1 0 2 4.2 C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm00019a001
CHEMBL25467 101751 5 None -1 7 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 263 1 0 2 4.2 C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm00019a001
107715 207724 22 None -13 20 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL1255837 207724 22 None -13 20 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL601773 207724 22 None -13 20 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
180 7189 56 None -7 40 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
200 7189 56 None -7 40 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
2160 7189 56 None -7 40 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
CHEMBL629 7189 56 None -7 40 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
DB00321 7189 56 None -7 40 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
49781887 23916 0 None -3 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 222 1 1 1 2.9 c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1 10.1021/jm1006269
CHEMBL1255617 23916 0 None -3 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 222 1 1 1 2.9 c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1 10.1021/jm1006269
10775000 114171 2 None 2 5 Rat 8.4 pKi = 8.4 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 214 1 2 2 2.6 Oc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL317912 114171 2 None 2 5 Rat 8.4 pKi = 8.4 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 214 1 2 2 2.6 Oc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
9837551 108401 0 None -25 3 Rat 7.5 pKi = 7.5 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 232 1 3 5 1.2 Cc1c(NC2=NCCN2)ccc2c1NCCO2 10.1021/jm960359r
CHEMBL298936 108401 0 None -25 3 Rat 7.5 pKi = 7.5 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 232 1 3 5 1.2 Cc1c(NC2=NCCN2)ccc2c1NCCO2 10.1021/jm960359r
1201549 7384 24 None -13 20 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
333 7384 24 None -13 20 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
7601 7384 24 None -13 20 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
CHEMBL1201203 7384 24 None -13 20 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
CHEMBL438151 7384 24 None -13 20 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
DB00245 7384 24 None -13 20 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
3584 10549 64 None -21 14 Human 7.5 pKi = 7.5 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980077m
5401 10549 64 None -21 14 Human 7.5 pKi = 7.5 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980077m
7302 10549 64 None -21 14 Human 7.5 pKi = 7.5 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980077m
CHEMBL611 10549 64 None -21 14 Human 7.5 pKi = 7.5 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980077m
DB01162 10549 64 None -21 14 Human 7.5 pKi = 7.5 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980077m
5282379 201763 69 None -2 3 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 300 5 1 1 5.6 CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1 nan
CHEMBL547 201763 69 None -2 3 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 300 5 1 1 5.6 CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1 nan
9813756 15788 0 None -5 3 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 255 2 2 2 2.8 CC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL109848 15788 0 None -5 3 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 255 2 2 2 2.8 CC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
24839550 144093 14 None -4 15 Human 6.5 pKi = 6.5 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 240 7 1 1 3.4 C=CCN(CC=C)CCc1c[nH]c2ccccc12 10.1016/j.bmcl.2015.12.053
CHEMBL3752576 144093 14 None -4 15 Human 6.5 pKi = 6.5 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 240 7 1 1 3.4 C=CCN(CC=C)CCc1c[nH]c2ccccc12 10.1016/j.bmcl.2015.12.053
44549156 25342 0 None -42 4 Human 6.5 pKi = 6.5 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 4 1 3 2.3 CC(Oc1ccccc1C1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL1276218 25342 0 None -42 4 Human 6.5 pKi = 6.5 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 4 1 3 2.3 CC(Oc1ccccc1C1CC1)C1=NCCN1 10.1021/ml400232p
45487956 205146 0 None -13 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 230 3 1 3 2.6 CC(OC1=NCCN1)c1ccccc1C1CC1 10.1021/jm901262f
CHEMBL576623 205146 0 None -13 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 230 3 1 3 2.6 CC(OC1=NCCN1)c1ccccc1C1CC1 10.1021/jm901262f
44549156 25342 0 None -42 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 4 1 3 2.3 CC(Oc1ccccc1C1CC1)C1=NCCN1 10.1021/jm100977d
CHEMBL1276218 25342 0 None -42 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 4 1 3 2.3 CC(Oc1ccccc1C1CC1)C1=NCCN1 10.1021/jm100977d
44325049 118300 0 None -51 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C(\C)c4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL327875 118300 0 None -51 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C(\C)c4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
2803 7742 58 None -1 19 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/j.bmc.2012.06.008
516 7742 58 None -1 19 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/j.bmc.2012.06.008
704 7742 58 None -1 19 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/j.bmc.2012.06.008
CHEMBL134 7742 58 None -1 19 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/j.bmc.2012.06.008
DB00575 7742 58 None -1 19 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/j.bmc.2012.06.008
44324859 118389 0 None -67 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 461 6 0 7 3.1 COc1cc2c(cc1OC)C1=NOC(CN3CCN(CC4=Cc5ccccc5C4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL328377 118389 0 None -67 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 461 6 0 7 3.1 COc1cc2c(cc1OC)C1=NOC(CN3CCN(CC4=Cc5ccccc5C4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
16090633 87236 0 None -83 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 380 4 2 5 3.8 C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CCN1C 10.1021/jm060262x
CHEMBL214661 87236 0 None -83 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 380 4 2 5 3.8 C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CCN1C 10.1021/jm060262x
10324985 83556 8 None -234 17 Human 6.5 pKi = 6.5 Binding
Binding affinity to adrenergic alpha-2B receptorBinding affinity to adrenergic alpha-2B receptor
ChEMBL 423 7 0 8 1.7 COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 10.1021/jm050725j
CHEMBL199824 83556 8 None -234 17 Human 6.5 pKi = 6.5 Binding
Binding affinity to adrenergic alpha-2B receptorBinding affinity to adrenergic alpha-2B receptor
ChEMBL 423 7 0 8 1.7 COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 10.1021/jm050725j
CHEMBL2068762 83556 8 None -234 17 Human 6.5 pKi = 6.5 Binding
Binding affinity to adrenergic alpha-2B receptorBinding affinity to adrenergic alpha-2B receptor
ChEMBL 423 7 0 8 1.7 COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 10.1021/jm050725j
49836308 25556 0 None -10 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 C[C@@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm100977d
CHEMBL1278084 25556 0 None -10 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 C[C@@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm100977d
6604789 107824 5 None -12 10 Human 5.5 pKi = 5.5 Binding
Binding affinity against Alpha-2B adrenergic receptorBinding affinity against Alpha-2B adrenergic receptor
ChEMBL 311 3 1 4 1.6 Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21 10.1016/0960-894X(95)00308-G
CHEMBL294649 107824 5 None -12 10 Human 5.5 pKi = 5.5 Binding
Binding affinity against Alpha-2B adrenergic receptorBinding affinity against Alpha-2B adrenergic receptor
ChEMBL 311 3 1 4 1.6 Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21 10.1016/0960-894X(95)00308-G
2719 7704 74 None -10 11 Human 4.5 pKi = 4.5 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC 10.1038/s41586-020-2286-9
5535 7704 74 None -10 11 Human 4.5 pKi = 4.5 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC 10.1038/s41586-020-2286-9
607 7704 74 None -10 11 Human 4.5 pKi = 4.5 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC 10.1038/s41586-020-2286-9
CHEMBL76 7704 74 None -10 11 Human 4.5 pKi = 4.5 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC 10.1038/s41586-020-2286-9
DB00608 7704 74 None -10 11 Human 4.5 pKi = 4.5 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC 10.1038/s41586-020-2286-9
3158 63041 27 None -218 20 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 nan
CHEMBL1628227 63041 27 None -218 20 Human 7.5 pKi = 7.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 nan
10266032 195660 0 None -2 3 Human 7.5 pKi = 7.5 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 286 5 1 3 3.5 c1ccc(CCC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1 10.1021/jm9905256
CHEMBL50720 195660 0 None -2 3 Human 7.5 pKi = 7.5 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 286 5 1 3 3.5 c1ccc(CCC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1 10.1021/jm9905256
4150 7575 39 None -81 12 Human 5.5 pKi = 5.5 Binding
Inhibition of alpha2B receptor (unknown origin)Inhibition of alpha2B receptor (unknown origin)
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1021/acs.jmedchem.0c00724
5288 7575 39 None -81 12 Human 5.5 pKi = 5.5 Binding
Inhibition of alpha2B receptor (unknown origin)Inhibition of alpha2B receptor (unknown origin)
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1021/acs.jmedchem.0c00724
644019 7575 39 None -81 12 Human 5.5 pKi = 5.5 Binding
Inhibition of alpha2B receptor (unknown origin)Inhibition of alpha2B receptor (unknown origin)
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1021/acs.jmedchem.0c00724
CHEMBL190461 7575 39 None -81 12 Human 5.5 pKi = 5.5 Binding
Inhibition of alpha2B receptor (unknown origin)Inhibition of alpha2B receptor (unknown origin)
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1021/acs.jmedchem.0c00724
DB09061 7575 39 None -81 12 Human 5.5 pKi = 5.5 Binding
Inhibition of alpha2B receptor (unknown origin)Inhibition of alpha2B receptor (unknown origin)
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1021/acs.jmedchem.0c00724
122186880 129758 0 None -33 5 Human 5.5 pKi = 5.5 Binding
Binding affinity to alpha2B adrenoceptor (unknown origin)Binding affinity to alpha2B adrenoceptor (unknown origin)
ChEMBL 415 3 0 5 4.8 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 10.1016/j.bmcl.2015.07.012
CHEMBL3608450 129758 0 None -33 5 Human 5.5 pKi = 5.5 Binding
Binding affinity to alpha2B adrenoceptor (unknown origin)Binding affinity to alpha2B adrenoceptor (unknown origin)
ChEMBL 415 3 0 5 4.8 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 10.1016/j.bmcl.2015.07.012
15675860 211208 0 None -4 4 Human 6.5 pKi = 6.5 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 305 1 2 5 2.1 Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1 10.1016/0960-894X(95)00391-6
CHEMBL72147 211208 0 None -4 4 Human 6.5 pKi = 6.5 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 305 1 2 5 2.1 Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1 10.1016/0960-894X(95)00391-6
44312036 211344 1 None -5 4 Human 5.5 pKi = 5.5 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 305 1 2 5 2.2 CC1CN=C(Nc2ccc3nccnc3c2Br)N1 10.1016/0960-894X(95)00391-6
CHEMBL72995 211344 1 None -5 4 Human 5.5 pKi = 5.5 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 305 1 2 5 2.2 CC1CN=C(Nc2ccc3nccnc3c2Br)N1 10.1016/0960-894X(95)00391-6
1530 8963 50 None -46 21 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
3827 8963 50 None -46 21 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
7206 8963 50 None -46 21 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
CHEMBL534 8963 50 None -46 21 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
DB00920 8963 50 None -46 21 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
73353884 99097 0 None -2 8 Human 5.5 pKi = 5.5 Binding
Inhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 295 3 1 3 2.7 c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2 10.1016/j.bmc.2013.07.045
CHEMBL2429890 99097 0 None -2 8 Human 5.5 pKi = 5.5 Binding
Inhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 295 3 1 3 2.7 c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2 10.1016/j.bmc.2013.07.045
44438148 100265 0 None -34 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 430 6 0 6 5.1 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL246229 100265 0 None -34 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 430 6 0 6 5.1 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2 10.1016/j.bmcl.2006.12.094
11140347 211312 1 None -53 6 Human 6.5 pKi = 6.5 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 239 4 2 4 2.0 CSc1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72768 211312 1 None -53 6 Human 6.5 pKi = 6.5 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 239 4 2 4 2.0 CSc1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
57345625 77954 0 None -11 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 224 3 1 3 2.1 CC(Oc1ccccc1Cl)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956191 77954 0 None -11 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 224 3 1 3 2.1 CC(Oc1ccccc1Cl)C1=NCCN1 10.1016/j.bmc.2012.01.035
11380132 91194 0 None -2 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1ccccn1)C1=NCCN1 10.1021/jm0408215
CHEMBL221989 91194 0 None -2 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1ccccn1)C1=NCCN1 10.1021/jm0408215
132060733 168903 0 None -1 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 294 3 0 3 3.0 c1ccc(CN2Cc3ccc(N4CCOCC4)cc3C2)cc1 10.1016/j.ejmech.2018.02.024
CHEMBL4161503 168903 0 None -1 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 294 3 0 3 3.0 c1ccc(CN2Cc3ccc(N4CCOCC4)cc3C2)cc1 10.1016/j.ejmech.2018.02.024
3191 109635 97 None -9 25 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL305660 109635 97 None -9 25 Human 6.5 pKi = 6.5 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
70693375 84446 0 None -8 4 Human 6.5 pKi = 6.5 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL2089155 84446 0 None -8 4 Human 6.5 pKi = 6.5 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
24906198 194443 3 None -12 4 Human 6.5 pKi = 6.5 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1 10.1021/ml400232p
CHEMBL495095 194443 3 None -12 4 Human 6.5 pKi = 6.5 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1 10.1021/ml400232p
24906198 194443 3 None -12 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1 10.1021/jm800250z
CHEMBL495095 194443 3 None -12 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1 10.1021/jm800250z
45487145 204438 0 None -5 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 230 4 1 3 2.5 C=CCc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
CHEMBL570973 204438 0 None -5 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 230 4 1 3 2.5 C=CCc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
24906198 194443 3 None -12 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1 10.1021/jm100977d
CHEMBL495095 194443 3 None -12 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1 10.1021/jm100977d
70693375 84446 0 None -8 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
CHEMBL2089155 84446 0 None -8 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
24906198 194443 3 None -12 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1 10.1021/ml300064v
CHEMBL495095 194443 3 None -12 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1 10.1021/ml300064v
2435 7509 100 None -36 12 Human 7.5 pKi = 7.5 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
395 7509 100 None -36 12 Human 7.5 pKi = 7.5 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
520 7509 100 None -36 12 Human 7.5 pKi = 7.5 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
5386 7509 100 None -36 12 Human 7.5 pKi = 7.5 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
CHEMBL844 7509 100 None -36 12 Human 7.5 pKi = 7.5 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
DB00484 7509 100 None -36 12 Human 7.5 pKi = 7.5 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
16090626 88910 0 None -218 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 378 3 1 4 4.9 Cc1nc2ccc(F)cc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
CHEMBL216727 88910 0 None -218 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 378 3 1 4 4.9 Cc1nc2ccc(F)cc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
16090622 89073 0 None -407 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 346 3 1 4 4.4 Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)C2)cc1 10.1021/jm060262x
CHEMBL217202 89073 0 None -407 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 346 3 1 4 4.4 Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)C2)cc1 10.1021/jm060262x
57345626 77955 2 None -15 4 Human 6.5 pKi = 6.5 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1 10.1021/ml400232p
CHEMBL1956192 77955 2 None -15 4 Human 6.5 pKi = 6.5 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1 10.1021/ml400232p
57345626 77955 2 None -15 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956192 77955 2 None -15 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1 10.1016/j.bmc.2012.01.035
11346584 143762 0 None -19 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm061487a
CHEMBL374584 143762 0 None -19 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm061487a
11346584 143762 0 None -19 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm0408215
CHEMBL374584 143762 0 None -19 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm0408215
11346584 143762 0 None -19 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm100977d
CHEMBL374584 143762 0 None -19 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1 10.1021/jm100977d
11199593 143977 0 None -10 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 282 4 1 3 3.8 CC(Sc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm0408215
CHEMBL374954 143977 0 None -10 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 282 4 1 3 3.8 CC(Sc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm0408215
CHEMBL5094181 222259 22 None -11 5 Human 5.5 pKi = 5.5 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1 10.6019/CHEMBL5058647
CHEMBL5094181 222259 22 None -11 5 Human 5.5 pKi = 5.5 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1 10.6019/CHEMBL5058647
44579187 196458 0 None -25 3 Human 7.4 pKi = 7.4 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 513 8 1 8 3.3 N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1 10.1016/j.bmcl.2008.08.055
CHEMBL515331 196458 0 None -25 3 Human 7.4 pKi = 7.4 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 513 8 1 8 3.3 N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1 10.1016/j.bmcl.2008.08.055
16090597 148248 0 None -9 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 3 1 4 5.4 Cc1nc2c(C)ccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
CHEMBL384318 148248 0 None -9 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 3 1 4 5.4 Cc1nc2c(C)ccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
70788951 33928 1 None -1 5 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL None None None None nan
CHEMBL1366 33928 1 None -1 5 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL None None None None nan
4209 9937 75 None -131 33 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
4893 9937 75 None -131 33 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
503 9937 75 None -131 33 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
5385 9937 75 None -131 33 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
CHEMBL2 9937 75 None -131 33 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
DB00457 9937 75 None -131 33 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
CHEMBL4802044 220837 1 None - 1 Human 5.4 pKi = 5.4 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None CC(=O)Nc1nc(CN2CCC[C@H](Cc3cc(C)nc(C)c3)C2)cs1 10.6019/CHEMBL4800731
9885114 126382 5 None -87 12 Rat 6.4 pKi = 6.4 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
ChEMBL 357 3 1 4 3.0 O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1 10.1021/jm990277d
CHEMBL346389 126382 5 None -87 12 Rat 6.4 pKi = 6.4 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
ChEMBL 357 3 1 4 3.0 O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1 10.1021/jm990277d
9885114 126382 5 None -87 12 Human 6.4 pKi = 6.4 Binding
Inhibition of alpha2B adrenergic receptor (unknown origin)Inhibition of alpha2B adrenergic receptor (unknown origin)
ChEMBL 357 3 1 4 3.0 O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1 10.1021/acs.jmedchem.7b00151
CHEMBL346389 126382 5 None -87 12 Human 6.4 pKi = 6.4 Binding
Inhibition of alpha2B adrenergic receptor (unknown origin)Inhibition of alpha2B adrenergic receptor (unknown origin)
ChEMBL 357 3 1 4 3.0 O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1 10.1021/acs.jmedchem.7b00151
CHEMBL4802044 220837 1 None - 1 Human 5.4 pKi = 5.4 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None CC(=O)Nc1nc(CN2CCC[C@H](Cc3cc(C)nc(C)c3)C2)cs1 10.6019/CHEMBL4800731
44438147 100264 0 None -19 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 406 5 1 9 2.5 COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL246228 100264 0 None -19 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 406 5 1 9 2.5 COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2 10.1016/j.bmcl.2006.12.094
44325044 214162 0 None -28 3 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 479 6 0 8 3.8 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4csc5ccccc45)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL93801 214162 0 None -28 3 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 479 6 0 8 3.8 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4csc5ccccc45)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
9923679 88537 0 None -7 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 332 3 1 4 4.0 Cc1cc(Nc2ccc(N3CCN(C)CC3)cc2)c2ccccc2n1 10.1021/jm060262x
CHEMBL216399 88537 0 None -7 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 332 3 1 4 4.0 Cc1cc(Nc2ccc(N3CCN(C)CC3)cc2)c2ccccc2n1 10.1021/jm060262x
10793963 106448 0 None -39 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 622 11 2 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL284470 106448 0 None -39 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 622 11 2 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
2812 11551 101 None -29 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 11551 101 None -29 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
9931977 69814 0 None -269 4 Human 6.4 pKi = 6.4 Binding
Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin
ChEMBL 421 4 0 7 3.3 COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4N=C(SC)N32)CC1 10.1021/jm970159v
CHEMBL1788223 69814 0 None -269 4 Human 6.4 pKi = 6.4 Binding
Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin
ChEMBL 421 4 0 7 3.3 COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4N=C(SC)N32)CC1 10.1021/jm970159v
2803 7742 58 None -1 19 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
516 7742 58 None -1 19 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
704 7742 58 None -1 19 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
CHEMBL134 7742 58 None -1 19 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
DB00575 7742 58 None -1 19 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
10682720 211941 0 None -9 3 Rat 6.4 pKi = 6.4 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 259 3 2 3 3.8 COc1cc(C)c(Nc2ncc[nH]2)cc1C(C)(C)C 10.1021/jm9605142
CHEMBL78190 211941 0 None -9 3 Rat 6.4 pKi = 6.4 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 259 3 2 3 3.8 COc1cc(C)c(Nc2ncc[nH]2)cc1C(C)(C)C 10.1021/jm9605142
10818003 113198 0 None -7 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 649 12 3 6 6.2 CC(C)C1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C(C)C)N1 10.1021/jm980077m
CHEMBL313953 113198 0 None -7 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 649 12 3 6 6.2 CC(C)C1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C(C)C)N1 10.1021/jm980077m
10507651 213286 0 None -42 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 591 9 2 6 5.8 CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
CHEMBL88388 213286 0 None -42 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 591 9 2 6 5.8 CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
122442272 145126 0 None -26 15 Human 6.4 pKi = 6.4 Binding
Binding affinity to human alpha-2B adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2B adrenergic receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
CHEMBL3769968 145126 0 None -26 15 Human 6.4 pKi = 6.4 Binding
Binding affinity to human alpha-2B adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2B adrenergic receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
CHEMBL3771384 145126 0 None -26 15 Human 6.4 pKi = 6.4 Binding
Binding affinity to human alpha-2B adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2B adrenergic receptor by radioligand binding assay
ChEMBL 239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN 10.1021/acs.jmedchem.5b01153
4567175 89251 5 None -5 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 318 3 1 4 3.7 CN1CCN(c2ccc(Nc3ccnc4ccccc34)cc2)CC1 10.1021/jm060262x
CHEMBL217665 89251 5 None -5 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 318 3 1 4 3.7 CN1CCN(c2ccc(Nc3ccnc4ccccc34)cc2)CC1 10.1021/jm060262x
10177445 172821 0 None -74 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 4 1 4 5.2 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1C(C)C 10.1021/jm060262x
CHEMBL425622 172821 0 None -74 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 374 4 1 4 5.2 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1C(C)C 10.1021/jm060262x
1028 7079 71 None -128 30 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
139148732 7079 71 None -128 30 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
479 7079 71 None -128 30 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
5816 7079 71 None -128 30 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
CHEMBL679 7079 71 None -128 30 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
DB00668 7079 71 None -128 30 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
49836301 25339 1 None -11 4 Human 6.4 pKi = 6.4 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/ml400232p
CHEMBL1276140 25339 1 None -11 4 Human 6.4 pKi = 6.4 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/ml400232p
153287574 182026 0 None -5 10 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 266 2 1 2 4.0 CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N 10.1021/acsmedchemlett.9b00225
CHEMBL4572167 182026 0 None -5 10 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 266 2 1 2 4.0 CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N 10.1021/acsmedchemlett.9b00225
11173544 173040 0 None -9 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 280 4 1 3 3.4 Cc1ccc(-c2ccccc2OC(C)C2=NCCN2)cc1 10.1021/jm0408215
CHEMBL426900 173040 0 None -9 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 280 4 1 3 3.4 Cc1ccc(-c2ccccc2OC(C)C2=NCCN2)cc1 10.1021/jm0408215
45487958 205170 0 None -11 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 190 2 1 3 1.5 Cc1ccccc1COC1=NCCN1 10.1021/jm901262f
CHEMBL576819 205170 0 None -11 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 190 2 1 3 1.5 Cc1ccccc1COC1=NCCN1 10.1021/jm901262f
49836301 25339 1 None -11 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/jm100977d
CHEMBL1276140 25339 1 None -11 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/jm100977d
49836301 25339 1 None -11 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/ml300064v
CHEMBL1276140 25339 1 None -11 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1 10.1021/ml300064v
11140345 210950 0 None -26 6 Human 5.4 pKi = 5.4 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 239 4 2 4 2.0 CSc1c(F)cccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70692 210950 0 None -26 6 Human 5.4 pKi = 5.4 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 239 4 2 4 2.0 CSc1c(F)cccc1NCC1=NCCN1 10.1021/jm000542r
136019934 151308 0 None -12 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 462 7 1 7 3.6 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2 10.1016/j.bmc.2007.03.053
CHEMBL390718 151308 0 None -12 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 462 7 1 7 3.6 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2 10.1016/j.bmc.2007.03.053
102 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
3659 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
8969 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
CHEMBL15245 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
DB01392 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
136 10065 32 None -5 16 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
223 10065 32 None -5 16 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
643606 10065 32 None -5 16 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
CHEMBL10347 10065 32 None -5 16 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
2274 9947 58 None -3 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
4917 9947 58 None -3 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
7279 9947 58 None -3 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
CHEMBL728 9947 58 None -3 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
DB00433 9947 58 None -3 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
2216 7234 50 None -1 6 Rat 8.3 pKi = 8.3 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 10.1021/jm960359r
229 7234 50 None -1 6 Rat 8.3 pKi = 8.3 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 10.1021/jm960359r
7117 7234 50 None -1 6 Rat 8.3 pKi = 8.3 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 10.1021/jm960359r
CHEMBL647 7234 50 None -1 6 Rat 8.3 pKi = 8.3 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 10.1021/jm960359r
DB00964 7234 50 None -1 6 Rat 8.3 pKi = 8.3 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 10.1021/jm960359r
44292385 107898 0 None -2 3 Human 7.4 pKi = 7.4 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 270 3 1 3 2.6 c1ccc(C[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1 10.1021/jm9905256
CHEMBL295186 107898 0 None -2 3 Human 7.4 pKi = 7.4 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 270 3 1 3 2.6 c1ccc(C[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1 10.1021/jm9905256
10848826 195659 0 None -1 3 Human 7.4 pKi = 7.4 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 258 3 1 3 2.8 c1ccc(C[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1 10.1021/jm9905256
CHEMBL50719 195659 0 None -1 3 Human 7.4 pKi = 7.4 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 258 3 1 3 2.8 c1ccc(C[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1 10.1021/jm9905256
33630 185736 99 None -9 28 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
CHEMBL47050 185736 99 None -9 28 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
44324972 170151 0 None -70 4 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL419316 170151 0 None -70 4 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
489 6933 28 None -1174 12 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
5640 6933 28 None -1174 12 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
CHEMBL420060 6933 28 None -1174 12 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
57345628 77958 0 None -38 4 Human 6.4 pKi = 6.4 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL1956195 77958 0 None -38 4 Human 6.4 pKi = 6.4 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
70695474 84447 0 None -70 4 Human 6.4 pKi = 6.4 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL2089156 84447 0 None -70 4 Human 6.4 pKi = 6.4 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml400232p
9894818 105701 0 None -125 7 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL279436 105701 0 None -125 7 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
57345628 77958 0 None -38 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956195 77958 0 None -38 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1016/j.bmc.2012.01.035
57345628 77958 0 None -38 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
CHEMBL1956195 77958 0 None -38 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
70695474 84447 0 None -70 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
CHEMBL2089156 84447 0 None -70 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1 10.1021/ml300064v
21509921 111235 0 None -40 24 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104091 111235 0 None -40 24 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
9894818 105701 0 None -125 7 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL279436 105701 0 None -125 7 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
21509921 111235 0 None -40 24 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104091 111235 0 None -40 24 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
11371902 148416 0 None -9 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 272 4 1 4 3.2 CC(Oc1ccccc1-c1ccsc1)C1=NCCN1 10.1021/jm0408215
CHEMBL385310 148416 0 None -9 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 272 4 1 4 3.2 CC(Oc1ccccc1-c1ccsc1)C1=NCCN1 10.1021/jm0408215
11371902 148416 0 None -9 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 272 4 1 4 3.2 CC(Oc1ccccc1-c1ccsc1)C1=NCCN1 10.1021/jm100977d
CHEMBL385310 148416 0 None -9 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 272 4 1 4 3.2 CC(Oc1ccccc1-c1ccsc1)C1=NCCN1 10.1021/jm100977d
10042547 83076 5 None -1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 334 1 1 2 3.9 CC1CCC(Nc2ccc(I)cc2Cl)=N1 10.1016/j.bmc.2012.06.008
CHEMBL2058635 83076 5 None -1 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 334 1 1 2 3.9 CC1CCC(Nc2ccc(I)cc2Cl)=N1 10.1016/j.bmc.2012.06.008
3584 10549 64 None -21 14 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
5401 10549 64 None -21 14 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
7302 10549 64 None -21 14 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
CHEMBL611 10549 64 None -21 14 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
DB01162 10549 64 None -21 14 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
44324765 118345 0 None -7 5 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 449 7 0 7 3.1 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL328114 118345 0 None -7 5 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 449 7 0 7 3.1 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
44324725 213596 0 None -21 3 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 451 8 0 7 3.1 COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCCc4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL90419 213596 0 None -21 3 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 451 8 0 7 3.1 COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCCc4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
9846548 214104 0 None -6 3 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 449 7 0 7 3.1 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL93489 214104 0 None -6 3 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 449 7 0 7 3.1 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
10382537 210945 12 None -6 6 Human 7.4 pKi = 7.4 Binding
Binding affinity for human alpha-2B adrenoceptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human alpha-2B adrenoceptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 339 1 2 5 1.6 Ic1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL70676 210945 12 None -6 6 Human 7.4 pKi = 7.4 Binding
Binding affinity for human alpha-2B adrenoceptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human alpha-2B adrenoceptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 339 1 2 5 1.6 Ic1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
68712 107114 60 None 1 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 10.1016/j.bmc.2012.06.008
CHEMBL289480 107114 60 None 1 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 10.1016/j.bmc.2012.06.008
487 10406 21 None -1096 12 Human 6.4 pKi = 6.4 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
60602 10406 21 None -1096 12 Human 6.4 pKi = 6.4 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
CHEMBL405355 10406 21 None -1096 12 Human 6.4 pKi = 6.4 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
DB09239 10406 21 None -1096 12 Human 6.4 pKi = 6.4 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
44390749 70684 0 None -223 6 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 607 11 3 6 5.3 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1016/s0960-894x(99)00484-9
CHEMBL180561 70684 0 None -223 6 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 607 11 3 6 5.3 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1016/s0960-894x(99)00484-9
10251036 88660 0 None -70 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 410 4 2 5 4.7 CN1CCN(c2ccc(Nc3c(CO)cnc4cc(Cl)ccc34)cc2)CC1(C)C 10.1021/jm060262x
CHEMBL216464 88660 0 None -70 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 410 4 2 5 4.7 CN1CCN(c2ccc(Nc3c(CO)cnc4cc(Cl)ccc34)cc2)CC1(C)C 10.1021/jm060262x
9859437 174801 0 None -69 3 Rat 6.4 pKi = 6.4 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 230 2 3 4 2.3 Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2 10.1021/jm9605142
CHEMBL432155 174801 0 None -69 3 Rat 6.4 pKi = 6.4 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 230 2 3 4 2.3 Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2 10.1021/jm9605142
66561967 81479 0 None -6 7 Human 5.4 pKi = 5.4 Binding
Inhibition of alpha2B adrenergic receptorInhibition of alpha2B adrenergic receptor
ChEMBL 213 2 0 1 2.0 C1CC2CCC1N2CC12C3C4C5C3C1C5C42 10.1016/j.bmcl.2012.04.077
CHEMBL2030626 81479 0 None -6 7 Human 5.4 pKi = 5.4 Binding
Inhibition of alpha2B adrenergic receptorInhibition of alpha2B adrenergic receptor
ChEMBL 213 2 0 1 2.0 C1CC2CCC1N2CC12C3C4C5C3C1C5C42 10.1016/j.bmcl.2012.04.077
CHEMBL4748908 220814 1 None -5 12 Human 6.4 pKi = 6.4 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1 10.6019/CHEMBL4800732
2585 7590 103 None -29 22 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
522 7590 103 None -29 22 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
551 7590 103 None -29 22 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
CHEMBL723 7590 103 None -29 22 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
DB01136 7590 103 None -29 22 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
1971 9641 38 None -3 30 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
2404 9641 38 None -3 30 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
4543 9641 38 None -3 30 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
CHEMBL445 9641 38 None -3 30 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
DB00540 9641 38 None -3 30 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
10198135 211904 3 None -43 3 Rat 6.4 pKi = 6.4 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 203 3 2 3 2.5 COc1ccc(Nc2ncc[nH]2)c(C)c1 10.1021/jm9605142
CHEMBL77913 211904 3 None -43 3 Rat 6.4 pKi = 6.4 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 203 3 2 3 2.5 COc1ccc(Nc2ncc[nH]2)c(C)c1 10.1021/jm9605142
73213196 111237 4 None -41 13 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104093 111237 4 None -41 13 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
9851486 213478 0 None -371 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 592 10 2 6 6.0 CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL89685 213478 0 None -371 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 592 10 2 6 6.0 CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
127036186 144192 0 None -13 19 Human 6.4 pKi = 6.4 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 254 7 1 1 3.7 C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL3753318 144192 0 None -13 19 Human 6.4 pKi = 6.4 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 254 7 1 1 3.7 C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 10.1016/j.bmcl.2015.12.053
73213196 111237 4 None -41 13 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104093 111237 4 None -41 13 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
12114853 19800 0 None -35 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 803 12 6 6 6.9 O=C(NCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL1189875 19800 0 None -35 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 803 12 6 6 6.9 O=C(NCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL539606 19800 0 None -35 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 803 12 6 6 6.9 O=C(NCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
24906196 194025 0 None -1 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 261 6 1 5 1.8 CCO/N=C/c1ccccc1OC(C)C1=NCCN1 10.1021/jm800250z
CHEMBL492639 194025 0 None -1 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 261 6 1 5 1.8 CCO/N=C/c1ccccc1OC(C)C1=NCCN1 10.1021/jm800250z
49836305 25348 0 None -10 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 272 4 1 4 3.2 C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1 10.1021/jm100977d
CHEMBL1276248 25348 0 None -10 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 272 4 1 4 3.2 C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1 10.1021/jm100977d
57401787 78028 0 None -1 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 308 3 1 4 2.3 c1ccc(C2(c3ccccc3)COCC(C3=NCCN3)O2)cc1 10.1016/j.bmc.2012.02.016
CHEMBL1956906 78028 0 None -1 3 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 308 3 1 4 2.3 c1ccc(C2(c3ccccc3)COCC(C3=NCCN3)O2)cc1 10.1016/j.bmc.2012.02.016
2337 10030 77 None -12 62 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
50 10030 77 None -12 62 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
5002 10030 77 None -12 62 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
CHEMBL716 10030 77 None -12 62 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
DB01224 10030 77 None -12 62 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
132060743 169015 0 None -1 13 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 351 3 0 4 3.1 CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 10.1016/j.ejmech.2018.02.024
CHEMBL4163428 169015 0 None -1 13 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 351 3 0 4 3.1 CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 10.1016/j.ejmech.2018.02.024
92766 113319 35 None -4 6 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 10.1021/jm00019a001
CHEMBL31410 113319 35 None -4 6 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 10.1021/jm00019a001
9906978 49485 2 None -125 12 Human 5.3 pKi = 5.3 Binding
Binding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assay
ChEMBL 361 6 1 3 4.0 O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 10.1016/j.bmcl.2006.03.057
CHEMBL150161 49485 2 None -125 12 Human 5.3 pKi = 5.3 Binding
Binding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assay
ChEMBL 361 6 1 3 4.0 O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 10.1016/j.bmcl.2006.03.057
5511 12260 40 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 4 0 2 3.3 Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1 nan
CHEMBL1076211 12260 40 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 245 4 0 2 3.3 Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1 nan
57395732 77966 0 None -9 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 342 5 1 3 4.8 CC(Oc1c(-c2ccccc2)cccc1-c1ccccc1)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956203 77966 0 None -9 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 342 5 1 3 4.8 CC(Oc1c(-c2ccccc2)cccc1-c1ccccc1)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL4521594 220756 28 None 1 2 Human 5.3 pKi = 5.3 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000309b ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000309b ADRA2B
ChEMBL None None None NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2)ccc1Oc1cccc(Cl)c1 10.6019/CHEMBL5212743
11765813 19750 0 None -60 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 788 11 6 6 6.5 O=C(NCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL1189483 19750 0 None -60 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 788 11 6 6 6.5 O=C(NCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL538808 19750 0 None -60 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 788 11 6 6 6.5 O=C(NCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
2398 7741 62 None -2 29 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
2801 7741 62 None -2 29 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
701 7741 62 None -2 29 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
CHEMBL415 7741 62 None -2 29 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
DB01242 7741 62 None -2 29 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
90469115 192621 4 None -1513 17 Human 5.3 pKi = 5.3 Binding
Binding affinity to human adrenergic alpha2B receptorBinding affinity to human adrenergic alpha2B receptor
ChEMBL 410 3 1 6 3.0 O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 10.1021/acs.jmedchem.1c00224
CHEMBL4867565 192621 4 None -1513 17 Human 5.3 pKi = 5.3 Binding
Binding affinity to human adrenergic alpha2B receptorBinding affinity to human adrenergic alpha2B receptor
ChEMBL 410 3 1 6 3.0 O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 10.1021/acs.jmedchem.1c00224
CHEMBL4513786 220746 7 None -851 8 Human 5.3 pKi = 5.3 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl ADRA2B
ChEMBL None None None CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC 10.6019/CHEMBL5212743
CHEMBL4796803 220746 7 None -851 8 Human 5.3 pKi = 5.3 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl ADRA2B
ChEMBL None None None CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC 10.6019/CHEMBL5212743
11465618 109175 23 None -173 19 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
CHEMBL3039528 109175 23 None -173 19 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
CHEMBL5191141 109175 23 None -173 19 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
44568614 194402 0 None 1 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 252 4 1 3 2.8 c1ccc(OC(C2=NCCN2)c2ccccc2)cc1 10.1021/jm800250z
CHEMBL494885 194402 0 None 1 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 252 4 1 3 2.8 c1ccc(OC(C2=NCCN2)c2ccccc2)cc1 10.1021/jm800250z
9944409 14385 0 None -1 5 Rat 7.3 pKi = 7.3 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 307 3 3 4 2.0 CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL108804 14385 0 None -1 5 Rat 7.3 pKi = 7.3 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 307 3 3 4 2.0 CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
164609539 191178 0 None -7 3 Human 5.3 pKi = 5.3 Binding
Inhibition of alpha2b adrenergic receptor (unknown origin)Inhibition of alpha2b adrenergic receptor (unknown origin)
ChEMBL 428 2 0 5 3.3 O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
CHEMBL4845850 191178 0 None -7 3 Human 5.3 pKi = 5.3 Binding
Inhibition of alpha2b adrenergic receptor (unknown origin)Inhibition of alpha2b adrenergic receptor (unknown origin)
ChEMBL 428 2 0 5 3.3 O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
CHEMBL4748908 220814 1 None -5 12 Human 6.3 pKi = 6.3 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1 10.6019/CHEMBL4800732
2435 7509 100 None -36 12 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
395 7509 100 None -36 12 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
520 7509 100 None -36 12 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
5386 7509 100 None -36 12 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
CHEMBL844 7509 100 None -36 12 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
DB00484 7509 100 None -36 12 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
26987 7736 33 None -281 21 Human 6.3 pKi = 6.3 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41586-020-2286-9
6063 7736 33 None -281 21 Human 6.3 pKi = 6.3 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41586-020-2286-9
671 7736 33 None -281 21 Human 6.3 pKi = 6.3 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41586-020-2286-9
CHEMBL1626 7736 33 None -281 21 Human 6.3 pKi = 6.3 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41586-020-2286-9
DB00283 7736 33 None -281 21 Human 6.3 pKi = 6.3 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41586-020-2286-9
24906241 199596 0 None -1 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2cccc3c2OC(C2=NCCN2)CO3)cc1 10.1021/jm800250z
CHEMBL522151 199596 0 None -1 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 280 2 1 4 2.5 c1ccc(-c2cccc3c2OC(C2=NCCN2)CO3)cc1 10.1021/jm800250z
11173568 91416 0 None -12 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 281 4 2 4 2.7 CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1 10.1021/jm0408215
CHEMBL222371 91416 0 None -12 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 281 4 2 4 2.7 CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1 10.1021/jm0408215
2142 9870 58 None -5 37 Human 7.3 pKi = 7.3 Binding
Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
4920903 9870 58 None -5 37 Human 7.3 pKi = 7.3 Binding
Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
502 9870 58 None -5 37 Human 7.3 pKi = 7.3 Binding
Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
5775 9870 58 None -5 37 Human 7.3 pKi = 7.3 Binding
Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
CHEMBL597 9870 58 None -5 37 Human 7.3 pKi = 7.3 Binding
Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
DB00692 9870 58 None -5 37 Human 7.3 pKi = 7.3 Binding
Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
131829 211506 15 None -7 6 Human 7.3 pKi = 7.3 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 295 1 4 5 1.7 Brc1c(NC2=NCCN2)ccc2c1NCCN2 10.1016/0960-894X(95)00391-6
CHEMBL74283 211506 15 None -7 6 Human 7.3 pKi = 7.3 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 295 1 4 5 1.7 Brc1c(NC2=NCCN2)ccc2c1NCCN2 10.1016/0960-894X(95)00391-6
11183468 116649 2 None 1 6 Rat 7.3 pKi = 7.3 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 213 1 2 2 2.5 Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL323402 116649 2 None 1 6 Rat 7.3 pKi = 7.3 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 213 1 2 2 2.5 Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
10603951 213295 0 None -23 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 622 10 1 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)N(C)CCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL88448 213295 0 None -23 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 622 10 1 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)N(C)CCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
44579185 188593 1 None -7 3 Human 7.3 pKi = 7.3 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 488 8 1 7 3.5 O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1 10.1016/j.bmcl.2008.08.055
CHEMBL477816 188593 1 None -7 3 Human 7.3 pKi = 7.3 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 488 8 1 7 3.5 O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1 10.1016/j.bmcl.2008.08.055
44215744 214221 0 None -15 3 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ccccc5c4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL94129 214221 0 None -15 3 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ccccc5c4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
11393666 199765 0 None -1258 19 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
CHEMBL5201983 199765 0 None -1258 19 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
CHEMBL5222597 199765 0 None -1258 19 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
44314198 111189 0 None -1 4 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 210 3 1 3 2.3 CCC[C@H]1CCCCC1NC1=NCCO1 10.1016/0960-894X(94)85032-1
CHEMBL310335 111189 0 None -1 4 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 210 3 1 3 2.3 CCC[C@H]1CCCCC1NC1=NCCO1 10.1016/0960-894X(94)85032-1
9815707 108246 0 None -1 3 Human 8.2 pKi = 8.2 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 210 3 1 3 2.3 CCC[C@H]1CCCC[C@@H]1NC1=NCCO1 10.1021/jm9905256
CHEMBL297752 108246 0 None -1 3 Human 8.2 pKi = 8.2 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 210 3 1 3 2.3 CCC[C@H]1CCCC[C@@H]1NC1=NCCO1 10.1021/jm9905256
10198108 214984 2 None -7 2 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 200 0 1 2 1.9 Cc1ccc2c(c1)CC1(CC2)CN=CN1 10.1021/jm00020a021
CHEMBL98471 214984 2 None -7 2 Rat 7.3 pKi = 7.3 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 200 0 1 2 1.9 Cc1ccc2c(c1)CC1(CC2)CN=CN1 10.1021/jm00020a021
137641762 164878 0 None -15 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Rauwolscine from human adrenergic alpha2B receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2B receptor
ChEMBL 476 5 4 10 1.1 CCCNc1nc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O 10.1021/acs.jmedchem.7b00141
CHEMBL4086593 164878 0 None -15 5 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Rauwolscine from human adrenergic alpha2B receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2B receptor
ChEMBL 476 5 4 10 1.1 CCCNc1nc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O 10.1021/acs.jmedchem.7b00141
137653203 165409 0 None -147 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Rauwolscine from human adrenergic alpha2B receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2B receptor
ChEMBL 449 3 3 11 0.8 CNc1nc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@@H]1O[C@H](C(=O)OC)[C@@H](O)[C@H]1O 10.1021/acs.jmedchem.7b00141
CHEMBL4092411 165409 0 None -147 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Rauwolscine from human adrenergic alpha2B receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2B receptor
ChEMBL 449 3 3 11 0.8 CNc1nc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@@H]1O[C@H](C(=O)OC)[C@@H](O)[C@H]1O 10.1021/acs.jmedchem.7b00141
72947314 99265 0 None -6 4 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 5 1 3 2.0 c1ccc(OCC2=NCCN2)c(CC2CC2)c1 10.1021/ml400232p
CHEMBL2431281 99265 0 None -6 4 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 5 1 3 2.0 c1ccc(OCC2=NCCN2)c(CC2CC2)c1 10.1021/ml400232p
44352207 25628 1 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm800250z
CHEMBL128168 25628 1 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm800250z
44352207 25628 1 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
CHEMBL128168 25628 1 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
44352207 25628 1 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm0408215
CHEMBL128168 25628 1 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm0408215
11246610 91087 0 None -4 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 CC(Oc1ccccc1-c1ccc([N+](=O)[O-])cc1)C1=NCCN1 10.1021/jm0408215
CHEMBL221523 91087 0 None -4 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 CC(Oc1ccccc1-c1ccc([N+](=O)[O-])cc1)C1=NCCN1 10.1021/jm0408215
44352207 25628 1 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
CHEMBL128168 25628 1 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
155536080 178893 0 None -34 10 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 219 2 1 2 2.9 CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N 10.1021/acsmedchemlett.9b00225
CHEMBL4472703 178893 0 None -34 10 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method
ChEMBL 219 2 1 2 2.9 CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N 10.1021/acsmedchemlett.9b00225
44328654 113962 0 None -134 6 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 663 14 3 6 6.7 CCCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCC)=C(CC)N1 10.1016/s0960-894x(99)00484-9
CHEMBL316495 113962 0 None -134 6 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 663 14 3 6 6.7 CCCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCC)=C(CC)N1 10.1016/s0960-894x(99)00484-9
16090631 89166 0 None -1047 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 390 4 2 5 4.5 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C(C)O 10.1021/jm060262x
CHEMBL217253 89166 0 None -1047 3 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 390 4 2 5 4.5 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C(C)O 10.1021/jm060262x
10531532 213873 0 None -58 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 594 9 2 7 6.0 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL91956 213873 0 None -58 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 594 9 2 7 6.0 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
57400959 77963 0 None -16 3 Human 4.3 pKi = 4.3 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 268 4 1 5 0.9 CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956200 77963 0 None -16 3 Human 4.3 pKi = 4.3 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 268 4 1 5 0.9 CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1 10.1016/j.bmc.2012.01.035
13091268 84999 0 None -562 14 Human 6.3 pKi = 6.3 Binding
Binding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assay
ChEMBL 401 6 1 3 5.0 O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 10.1016/j.bmcl.2006.03.057
CHEMBL210578 84999 0 None -562 14 Human 6.3 pKi = 6.3 Binding
Binding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assay
ChEMBL 401 6 1 3 5.0 O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 10.1016/j.bmcl.2006.03.057
2435 7509 100 None -3 12 Rat 7.3 pKi = 7.3 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
395 7509 100 None -3 12 Rat 7.3 pKi = 7.3 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
520 7509 100 None -3 12 Rat 7.3 pKi = 7.3 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
5386 7509 100 None -3 12 Rat 7.3 pKi = 7.3 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
CHEMBL844 7509 100 None -3 12 Rat 7.3 pKi = 7.3 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
DB00484 7509 100 None -3 12 Rat 7.3 pKi = 7.3 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1021/jm9605142
240 7731 43 None -11 25 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
2769 7731 43 None -11 25 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
44279790 7731 43 None -11 25 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
660 7731 43 None -11 25 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
CHEMBL1729 7731 43 None -11 25 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
CHEMBL560739 7731 43 None -11 25 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
DB00604 7731 43 None -11 25 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
2765 7730 19 None -15 9 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/ml400232p
515 7730 19 None -15 9 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/ml400232p
CHEMBL13852 7730 19 None -15 9 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/ml400232p
DB09202 7730 19 None -15 9 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/ml400232p
2765 7730 19 None -15 9 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/jm901262f
515 7730 19 None -15 9 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/jm901262f
CHEMBL13852 7730 19 None -15 9 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/jm901262f
DB09202 7730 19 None -15 9 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1021/jm901262f
3033538 8101 39 None -11 9 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
7155 8101 39 None -11 9 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
781 8101 39 None -11 9 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
CHEMBL1201216 8101 39 None -11 9 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
DB00298 8101 39 None -11 9 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
1443 8809 34 None -12 11 Human 6.3 pKi = 6.3 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
33625 8809 34 None -12 11 Human 6.3 pKi = 6.3 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
501 8809 34 None -12 11 Human 6.3 pKi = 6.3 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
CHEMBL279516 8809 34 None -12 11 Human 6.3 pKi = 6.3 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
DB08950 8809 34 None -12 11 Human 6.3 pKi = 6.3 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
44288874 107872 0 None -524 7 Human 6.3 pKi = 6.3 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 528 7 2 4 4.2 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
CHEMBL295001 107872 0 None -524 7 Human 6.3 pKi = 6.3 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 528 7 2 4 4.2 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
139406787 183924 0 None -5 4 Human 5.3 pKi = 5.3 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin)Binding affinity to adrenergic alpha2B receptor (unknown origin)
ChEMBL 492 5 2 5 5.8 O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-c2cn(-c3ccc(C(F)(F)F)cc3)nn2)c1 10.1021/acs.jmedchem.0c00745
CHEMBL4633982 183924 0 None -5 4 Human 5.3 pKi = 5.3 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin)Binding affinity to adrenergic alpha2B receptor (unknown origin)
ChEMBL 492 5 2 5 5.8 O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-c2cn(-c3ccc(C(F)(F)F)cc3)nn2)c1 10.1021/acs.jmedchem.0c00745
448537 167029 89 None -33 25 Human 5.3 pKi = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 167029 89 None -33 25 Human 5.3 pKi = 5.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
73291731 99266 0 None -38 4 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 232 5 1 3 2.4 CCCc1ccccc1OC(C)C1=NCCN1 10.1021/ml400232p
CHEMBL2431282 99266 0 None -38 4 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 232 5 1 3 2.4 CCCc1ccccc1OC(C)C1=NCCN1 10.1021/ml400232p
11277479 91525 0 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 280 4 1 3 3.4 Cc1cccc(-c2ccccc2OC(C)C2=NCCN2)c1 10.1021/jm0408215
CHEMBL222973 91525 0 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 280 4 1 3 3.4 Cc1cccc(-c2ccccc2OC(C)C2=NCCN2)c1 10.1021/jm0408215
45487955 205089 0 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 232 4 1 3 2.7 CCCc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
CHEMBL576078 205089 0 None -10 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 232 4 1 3 2.7 CCCc1ccccc1C(C)OC1=NCCN1 10.1021/jm901262f
124 9755 47 None -977 32 Human 5.3 pKi = 5.3 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
2032 9755 47 None -977 32 Human 5.3 pKi = 5.3 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
4636 9755 47 None -977 32 Human 5.3 pKi = 5.3 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
CHEMBL762 9755 47 None -977 32 Human 5.3 pKi = 5.3 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
DB00935 9755 47 None -977 32 Human 5.3 pKi = 5.3 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
44269013 37115 1 None -11 4 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 218 5 1 3 2.0 CCCc1ccccc1OCC1=NCCN1 10.1021/ml400232p
CHEMBL13917 37115 1 None -11 4 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 218 5 1 3 2.0 CCCc1ccccc1OCC1=NCCN1 10.1021/ml400232p
45487962 204264 0 None -11 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 218 4 1 3 2.1 CCCc1ccccc1COC1=NCCN1 10.1021/jm901262f
CHEMBL569933 204264 0 None -11 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 218 4 1 3 2.1 CCCc1ccccc1COC1=NCCN1 10.1021/jm901262f
122065 196328 3 None -112 8 Human 7.3 pKi = 7.3 Binding
Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin
ChEMBL 380 5 1 6 1.5 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 10.1021/jm970159v
CHEMBL51433 196328 3 None -112 8 Human 7.3 pKi = 7.3 Binding
Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin
ChEMBL 380 5 1 6 1.5 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 10.1021/jm970159v
73346042 98609 5 None -562 17 Human 7.3 pKi = 7.3 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin)Binding affinity to adrenergic alpha2B receptor (unknown origin)
ChEMBL 405 9 0 8 0.9 Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O 10.1016/j.bmc.2013.05.050
CHEMBL2413153 98609 5 None -562 17 Human 7.3 pKi = 7.3 Binding
Binding affinity to adrenergic alpha2B receptor (unknown origin)Binding affinity to adrenergic alpha2B receptor (unknown origin)
ChEMBL 405 9 0 8 0.9 Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O 10.1016/j.bmc.2013.05.050
2406 107180 89 None -10 12 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL290106 107180 89 None -10 12 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
49836302 25338 1 None -5 3 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1 10.1021/ml400232p
CHEMBL1276139 25338 1 None -5 3 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1 10.1021/ml400232p
49836304 25343 1 None -12 3 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 4 1 3 2.3 C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/ml400232p
CHEMBL1276219 25343 1 None -12 3 Human 6.3 pKi = 6.3 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 230 4 1 3 2.3 C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/ml400232p
49836302 25338 1 None -5 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1 10.1021/jm100977d
CHEMBL1276139 25338 1 None -5 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1 10.1021/jm100977d
49836304 25343 1 None -12 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 4 1 3 2.3 C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/jm100977d
CHEMBL1276219 25343 1 None -12 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 230 4 1 3 2.3 C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1 10.1021/jm100977d
49836302 25338 1 None -5 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1 10.1021/ml300064v
CHEMBL1276139 25338 1 None -5 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
ChEMBL 230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1 10.1021/ml300064v
9960497 107252 0 None -1778 6 Human 6.2 pKi = 6.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.9 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
CHEMBL290860 107252 0 None -1778 6 Human 6.2 pKi = 6.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.9 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
15730 77893 80 None -2 10 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
CHEMBL195437 77893 80 None -2 10 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
145990586 173622 0 None -44 11 Human 6.2 pKi = 6.2 Binding
Binding affinity to andrenergic alpha2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to andrenergic alpha2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay
ChEMBL 297 2 2 4 2.6 COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 10.1039/C7MD00656J
CHEMBL4285281 173622 0 None -44 11 Human 6.2 pKi = 6.2 Binding
Binding affinity to andrenergic alpha2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to andrenergic alpha2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay
ChEMBL 297 2 2 4 2.6 COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 10.1039/C7MD00656J
11057 182928 23 None -1 20 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
3468 182928 23 None -1 20 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL459265 182928 23 None -1 20 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL64894 182928 23 None -1 20 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
10508332 112768 0 None -389 6 Human 6.2 pKi = 6.2 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 638 11 2 8 6.4 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])c(OC)c1 10.1021/jm980077m
CHEMBL313160 112768 0 None -389 6 Human 6.2 pKi = 6.2 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 638 11 2 8 6.4 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])c(OC)c1 10.1021/jm980077m
11801828 213323 0 None -35 6 Human 6.2 pKi = 6.2 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 606 9 3 6 5.0 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
CHEMBL88628 213323 0 None -35 6 Human 6.2 pKi = 6.2 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 606 9 3 6 5.0 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
10362866 89074 0 None -114 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 3 1 4 5.4 Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1C 10.1021/jm060262x
CHEMBL217203 89074 0 None -114 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 3 1 4 5.4 Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1C 10.1021/jm060262x
124 9755 47 None -977 32 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
2032 9755 47 None -977 32 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
4636 9755 47 None -977 32 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
CHEMBL762 9755 47 None -977 32 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
DB00935 9755 47 None -977 32 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
44438161 153919 0 None -63 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 543 10 1 7 5.0 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL392771 153919 0 None -63 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 543 10 1 7 5.0 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2 10.1016/j.bmcl.2006.12.094
10333157 158017 0 None -6 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
CHEMBL396013 158017 0 None -6 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm061487a
10333157 158017 0 None -6 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
CHEMBL396013 158017 0 None -6 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 10.1021/jm100977d
176 7186 66 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 7186 66 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 7186 66 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 7186 66 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 7186 66 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
10489502 11290 2 None -6 3 Rat 6.2 pKi = 6.2 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 227 2 2 2 3.5 Clc1cccc(Cl)c1Nc1ncc[nH]1 10.1021/jm9605142
CHEMBL1022 11290 2 None -6 3 Rat 6.2 pKi = 6.2 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 227 2 2 2 3.5 Clc1cccc(Cl)c1Nc1ncc[nH]1 10.1021/jm9605142
2803 7742 58 None -1 19 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/0960-894X(94)85032-1
516 7742 58 None -1 19 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/0960-894X(94)85032-1
704 7742 58 None -1 19 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/0960-894X(94)85032-1
CHEMBL134 7742 58 None -1 19 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/0960-894X(94)85032-1
DB00575 7742 58 None -1 19 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1016/0960-894X(94)85032-1
49781007 24013 0 None -4 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 254 4 1 2 3.3 CCCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1256566 24013 0 None -4 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 254 4 1 2 3.3 CCCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
213041 23905 28 None 1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 230 2 1 1 3.0 CCC1(c2c[nH]cn2)Cc2ccc(F)cc2C1 10.1021/jm1006269
CHEMBL1255582 23905 28 None 1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 230 2 1 1 3.0 CCC1(c2c[nH]cn2)Cc2ccc(F)cc2C1 10.1021/jm1006269
49781887 23916 0 None -3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 222 1 1 1 2.9 c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1 10.1021/jm1006269
CHEMBL1255617 23916 0 None -3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 222 1 1 1 2.9 c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1 10.1021/jm1006269
129211 10521 78 None -102 16 Rat 8.2 pKi = 8.2 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
2562 10521 78 None -102 16 Rat 8.2 pKi = 8.2 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
488 10521 78 None -102 16 Rat 8.2 pKi = 8.2 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
CHEMBL836 10521 78 None -102 16 Rat 8.2 pKi = 8.2 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
DB00706 10521 78 None -102 16 Rat 8.2 pKi = 8.2 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
10707358 186064 0 None -4 3 Human 8.2 pKi = 8.2 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 272 4 1 3 3.2 c1ccc(CC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1 10.1021/jm9905256
CHEMBL47313 186064 0 None -4 3 Human 8.2 pKi = 8.2 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 272 4 1 3 3.2 c1ccc(CC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1 10.1021/jm9905256
16090623 89229 0 None -77 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 3 1 4 5.4 Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1C 10.1021/jm060262x
CHEMBL217567 89229 0 None -77 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 3 1 4 5.4 Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1C 10.1021/jm060262x
2750 210840 76 None -3 12 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
CHEMBL7002 210840 76 None -3 12 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
28918670 99262 2 None -6 4 Human 6.2 pKi = 6.2 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 254 3 1 3 1.8 Brc1ccccc1OCC1=NCCN1 10.1021/ml400232p
CHEMBL2431279 99262 2 None -6 4 Human 6.2 pKi = 6.2 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 254 3 1 3 1.8 Brc1ccccc1OCC1=NCCN1 10.1021/ml400232p
57395731 77965 0 None -6 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 232 4 1 4 1.7 CC(=O)c1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956202 77965 0 None -6 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 232 4 1 4 1.7 CC(=O)c1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
1353 8692 93 None -85 85 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
3559 8692 93 None -85 85 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
86 8692 93 None -85 85 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
CHEMBL54 8692 93 None -85 85 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
DB00502 8692 93 None -85 85 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
9815610 106709 19 None -31 4 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 202 1 1 2 2.8 C1=C(c2c[nH]cn2)c2ccsc2CC1 10.1021/jm990569e
CHEMBL286246 106709 19 None -31 4 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 202 1 1 2 2.8 C1=C(c2c[nH]cn2)c2ccsc2CC1 10.1021/jm990569e
9815610 106709 19 None -31 4 Rat 6.2 pKi = 6.2 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 202 1 1 2 2.8 C1=C(c2c[nH]cn2)c2ccsc2CC1 10.1021/jm000128r
CHEMBL286246 106709 19 None -31 4 Rat 6.2 pKi = 6.2 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 202 1 1 2 2.8 C1=C(c2c[nH]cn2)c2ccsc2CC1 10.1021/jm000128r
10655607 211534 5 None -8 3 Rat 6.2 pKi = 6.2 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 199 2 3 3 2.0 c1c[nH]c(Nc2ccc3[nH]cnc3c2)n1 10.1021/jm9605142
CHEMBL74544 211534 5 None -8 3 Rat 6.2 pKi = 6.2 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 199 2 3 3 2.0 c1c[nH]c(Nc2ccc3[nH]cnc3c2)n1 10.1021/jm9605142
46869265 23029 0 None -30 7 Human 5.2 pKi = 5.2 Binding
Binding affinity to adrenergic alpha2B receptorBinding affinity to adrenergic alpha2B receptor
ChEMBL 295 1 3 3 3.1 Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21 10.1016/j.bmc.2010.07.052
CHEMBL1224527 23029 0 None -30 7 Human 5.2 pKi = 5.2 Binding
Binding affinity to adrenergic alpha2B receptorBinding affinity to adrenergic alpha2B receptor
ChEMBL 295 1 3 3 3.1 Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21 10.1016/j.bmc.2010.07.052
491 6980 9 None -812 12 Rat 7.2 pKi = 7.2 Binding
Ancillary Binding affinity towards rat alpha-2B receptorAncillary Binding affinity towards rat alpha-2B receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
9891167 6980 9 None -812 12 Rat 7.2 pKi = 7.2 Binding
Ancillary Binding affinity towards rat alpha-2B receptorAncillary Binding affinity towards rat alpha-2B receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
CHEMBL13856 6980 9 None -812 12 Rat 7.2 pKi = 7.2 Binding
Ancillary Binding affinity towards rat alpha-2B receptorAncillary Binding affinity towards rat alpha-2B receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
463 8187 22 None -57 13 Human 6.2 pKi = 6.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
6918097 8187 22 None -57 13 Human 6.2 pKi = 6.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
837 8187 22 None -57 13 Human 6.2 pKi = 6.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
CHEMBL2051956 8187 22 None -57 13 Human 6.2 pKi = 6.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
DB14068 8187 22 None -57 13 Human 6.2 pKi = 6.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
11361608 91520 1 None -10 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm061487a
CHEMBL222928 91520 1 None -10 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm061487a
11361608 91520 1 None -10 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm0408215
CHEMBL222928 91520 1 None -10 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm0408215
11361608 91520 1 None -10 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm100977d
CHEMBL222928 91520 1 None -10 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm100977d
9944467 16023 0 None -3 4 Rat 6.2 pKi = 6.2 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 309 2 2 2 3.4 O=C(Nc1cccc2c1CCCC2c1c[nH]cn1)C(F)(F)F 10.1021/jm030551a
CHEMBL110751 16023 0 None -3 4 Rat 6.2 pKi = 6.2 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 309 2 2 2 3.4 O=C(Nc1cccc2c1CCCC2c1c[nH]cn1)C(F)(F)F 10.1021/jm030551a
10176567 109577 3 None -24 4 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 200 1 1 2 3.3 c1cc(-c2c[nH]cn2)c2ccsc2c1 10.1021/jm990569e
CHEMBL30534 109577 3 None -24 4 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 200 1 1 2 3.3 c1cc(-c2c[nH]cn2)c2ccsc2c1 10.1021/jm990569e
10176567 109577 3 None -24 4 Rat 6.2 pKi = 6.2 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 200 1 1 2 3.3 c1cc(-c2c[nH]cn2)c2ccsc2c1 10.1021/jm000128r
CHEMBL30534 109577 3 None -24 4 Rat 6.2 pKi = 6.2 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 200 1 1 2 3.3 c1cc(-c2c[nH]cn2)c2ccsc2c1 10.1021/jm000128r
73349359 99318 0 None 1 8 Human 6.2 pKi = 6.2 Binding
Inhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 341 6 1 4 2.9 COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC 10.1016/j.bmc.2013.07.045
CHEMBL2432051 99318 0 None 1 8 Human 6.2 pKi = 6.2 Binding
Inhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 341 6 1 4 2.9 COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC 10.1016/j.bmc.2013.07.045
1593 9119 66 None -6 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1016/j.bmc.2012.01.035
30668 9119 66 None -6 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1016/j.bmc.2012.01.035
9868 9119 66 None -6 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1016/j.bmc.2012.01.035
CHEMBL17860 9119 66 None -6 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1016/j.bmc.2012.01.035
DB04948 9119 66 None -6 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 10.1016/j.bmc.2012.01.035
164618319 191372 0 None -6 3 Human 5.2 pKi = 5.2 Binding
Inhibition of alpha2b adrenergic receptor (unknown origin)Inhibition of alpha2b adrenergic receptor (unknown origin)
ChEMBL 340 2 1 4 2.1 CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
CHEMBL4848838 191372 0 None -6 3 Human 5.2 pKi = 5.2 Binding
Inhibition of alpha2b adrenergic receptor (unknown origin)Inhibition of alpha2b adrenergic receptor (unknown origin)
ChEMBL 340 2 1 4 2.1 CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
49783209 24381 0 None -1174 26 Human 6.2 pKi = 6.2 Binding
Binding affinity to human adrenergic alpha2B receptorBinding affinity to human adrenergic alpha2B receptor
ChEMBL 396 7 1 6 3.8 CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 10.1021/jm100668r
CHEMBL1258223 24381 0 None -1174 26 Human 6.2 pKi = 6.2 Binding
Binding affinity to human adrenergic alpha2B receptorBinding affinity to human adrenergic alpha2B receptor
ChEMBL 396 7 1 6 3.8 CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 10.1021/jm100668r
44288847 172088 0 None -478 5 Human 6.2 pKi = 6.2 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 535 7 2 5 3.9 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
CHEMBL42335 172088 0 None -478 5 Human 6.2 pKi = 6.2 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 535 7 2 5 3.9 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
11109088 210959 0 None -144 6 Human 6.2 pKi = 6.2 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 255 4 2 4 2.5 CSc1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70751 210959 0 None -144 6 Human 6.2 pKi = 6.2 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 255 4 2 4 2.5 CSc1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
9904117 16174 3 None -6 5 Rat 6.2 pKi = 6.2 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL111554 16174 3 None -6 5 Rat 6.2 pKi = 6.2 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
3952 8669 38 None -18 12 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5353646 8669 38 None -18 12 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5443 8669 38 None -18 12 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5702063 8669 38 None -18 12 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
CHEMBL1331786 8669 38 None -18 12 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
CHEMBL420 8669 38 None -18 12 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
3086326 211310 22 None -1 6 Human 7.2 pKi = 7.2 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 247 1 2 5 1.7 Clc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL72753 211310 22 None -1 6 Human 7.2 pKi = 7.2 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 247 1 2 5 1.7 Clc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
44579271 193873 0 None -22 3 Human 7.2 pKi = 7.2 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 475 9 0 7 4.2 c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1 10.1016/j.bmcl.2008.08.055
CHEMBL491419 193873 0 None -22 3 Human 7.2 pKi = 7.2 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 475 9 0 7 4.2 c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1 10.1016/j.bmcl.2008.08.055
2662 18156 131 None -1 30 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 nan
CHEMBL118 18156 131 None -1 30 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 nan
1209 8439 75 None -12 32 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F nan
203 8439 75 None -12 32 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F nan
3386 8439 75 None -12 32 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F nan
CHEMBL41 8439 75 None -12 32 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F nan
DB00472 8439 75 None -12 32 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F nan
9805944 63001 37 None -11 9 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]HEAT from adrenergic alpha2B receptorDisplacement of [125I]HEAT from adrenergic alpha2B receptor
ChEMBL 462 7 2 3 4.7 CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm800510m
CHEMBL1627 63001 37 None -11 9 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]HEAT from adrenergic alpha2B receptorDisplacement of [125I]HEAT from adrenergic alpha2B receptor
ChEMBL 462 7 2 3 4.7 CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm800510m
102 10899 48 None -10 49 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards alpha-2b adrenergic receptorIn vitro binding affinity towards alpha-2b adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2005.03.116
3659 10899 48 None -10 49 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards alpha-2b adrenergic receptorIn vitro binding affinity towards alpha-2b adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2005.03.116
8969 10899 48 None -10 49 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards alpha-2b adrenergic receptorIn vitro binding affinity towards alpha-2b adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2005.03.116
CHEMBL15245 10899 48 None -10 49 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards alpha-2b adrenergic receptorIn vitro binding affinity towards alpha-2b adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2005.03.116
DB01392 10899 48 None -10 49 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards alpha-2b adrenergic receptorIn vitro binding affinity towards alpha-2b adrenergic receptor
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1016/j.bmcl.2005.03.116
11653915 130790 0 None -1 6 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 296 4 2 5 2.6 COc1cccc(N(NC2=NCCN2)c2ccc(C)cc2)c1 10.1016/j.bmcl.2005.07.083
CHEMBL362954 130790 0 None -1 6 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 296 4 2 5 2.6 COc1cccc(N(NC2=NCCN2)c2ccc(C)cc2)c1 10.1016/j.bmcl.2005.07.083
44325050 214060 0 None -38 3 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL93171 214060 0 None -38 3 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
133 9274 52 None -14 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
1723 9274 52 None -14 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
28693 9274 52 None -14 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL19215 9274 52 None -14 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
DB13520 9274 52 None -14 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
2142 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm00018a001
4920903 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm00018a001
502 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm00018a001
5775 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm00018a001
CHEMBL597 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm00018a001
DB00692 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm00018a001
3584 10549 64 None -3 14 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
5401 10549 64 None -3 14 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
7302 10549 64 None -3 14 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
CHEMBL611 10549 64 None -3 14 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
DB01162 10549 64 None -3 14 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
49781005 23986 0 None -3 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 226 2 1 2 2.5 CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1256503 23986 0 None -3 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 226 2 1 2 2.5 CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
102 10899 48 None -10 49 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
3659 10899 48 None -10 49 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
8969 10899 48 None -10 49 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
CHEMBL15245 10899 48 None -10 49 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
DB01392 10899 48 None -10 49 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
68712 107114 60 None 1 5 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 10.1016/0960-894X(94)85032-1
CHEMBL289480 107114 60 None 1 5 Human 7.2 pKi = 7.2 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 10.1016/0960-894X(94)85032-1
44269006 39127 1 None -10 4 Human 6.2 pKi = 6.2 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 216 5 1 3 1.8 C=CCc1ccccc1OCC1=NCCN1 10.1021/ml400232p
CHEMBL14107 39127 1 None -10 4 Human 6.2 pKi = 6.2 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 216 5 1 3 1.8 C=CCc1ccccc1OCC1=NCCN1 10.1021/ml400232p
24906159 194184 12 None -2 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 233 4 2 5 1.3 CC(Oc1ccccc1/C=N/O)C1=NCCN1 10.1021/jm800250z
CHEMBL493675 194184 12 None -2 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 233 4 2 5 1.3 CC(Oc1ccccc1/C=N/O)C1=NCCN1 10.1021/jm800250z
49836306 25347 0 None -4 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 272 4 1 4 3.2 C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1 10.1021/jm100977d
CHEMBL1276247 25347 0 None -4 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 272 4 1 4 3.2 C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1 10.1021/jm100977d
490 6979 8 None -691 12 Rat 7.2 pKi = 7.2 Binding
Ancillary Binding affinity towards rat alpha-2B receptorAncillary Binding affinity towards rat alpha-2B receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
9890547 6979 8 None -691 12 Rat 7.2 pKi = 7.2 Binding
Ancillary Binding affinity towards rat alpha-2B receptorAncillary Binding affinity towards rat alpha-2B receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
CHEMBL268758 6979 8 None -691 12 Rat 7.2 pKi = 7.2 Binding
Ancillary Binding affinity towards rat alpha-2B receptorAncillary Binding affinity towards rat alpha-2B receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
118717248 121902 0 None -2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting
ChEMBL 219 1 2 3 0.5 Fc1ccc2cnn(N=C3NCCN3)c2c1 10.1016/j.ejmech.2014.09.083
CHEMBL3343699 121902 0 None -2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting
ChEMBL 219 1 2 3 0.5 Fc1ccc2cnn(N=C3NCCN3)c2c1 10.1016/j.ejmech.2014.09.083
10758200 70191 0 None -30 5 Human 7.1 pKi = 7.1 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 322 4 0 3 3.2 c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1 10.1016/j.bmcl.2008.08.055
CHEMBL179648 70191 0 None -30 5 Human 7.1 pKi = 7.1 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 322 4 0 3 3.2 c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1 10.1016/j.bmcl.2008.08.055
1548953 214458 27 None -3 17 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL954 214458 27 None -3 17 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
44325038 213695 0 None -19 3 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 474 6 0 8 3.2 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ncccc5c4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL90966 213695 0 None -19 3 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 474 6 0 8 3.2 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ncccc5c4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
50878551 97520 61 None -18 18 Human 6.1 pKi = 6.1 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL2391541 97520 61 None -18 18 Human 6.1 pKi = 6.1 Binding
Binding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2B adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 10.1016/j.bmcl.2015.12.053
3652 53018 70 None -4 9 Human 4.1 pKi = 4.1 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 10.1038/s41586-020-2286-9
CHEMBL1535 53018 70 None -4 9 Human 4.1 pKi = 4.1 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 10.1038/s41586-020-2286-9
8447 195728 84 None 2 13 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 332 3 0 6 5.7 c1ccc2sc(SSc3nc4ccccc4s3)nc2c1 nan
CHEMBL508112 195728 84 None 2 13 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 332 3 0 6 5.7 c1ccc2sc(SSc3nc4ccccc4s3)nc2c1 nan
16757089 99066 1 None -9 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm061487a
CHEMBL242693 99066 1 None -9 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm061487a
16757089 99066 1 None -9 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm100977d
CHEMBL242693 99066 1 None -9 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells
ChEMBL 311 5 1 5 3.0 C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1 10.1021/jm100977d
16725934 154201 0 None -38 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 429 6 0 5 5.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL392992 154201 0 None -38 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 429 6 0 5 5.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2 10.1016/j.bmcl.2006.12.094
44328920 115418 0 None -66 6 Human 6.1 pKi = 6.1 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 705 14 3 7 5.9 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCC(F)(F)F)N1 10.1016/s0960-894x(99)00484-9
CHEMBL320736 115418 0 None -66 6 Human 6.1 pKi = 6.1 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 705 14 3 7 5.9 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCC(F)(F)F)N1 10.1016/s0960-894x(99)00484-9
9960497 123853 0 None -229 6 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
CHEMBL3392246 123853 0 None -229 6 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
49783419 24521 0 None -2344 12 Human 6.1 pKi = 6.1 Binding
Binding affinity to human adrenergic alpha2B receptorBinding affinity to human adrenergic alpha2B receptor
ChEMBL 366 6 1 6 2.8 CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 10.1021/jm100668r
CHEMBL1258671 24521 0 None -2344 12 Human 6.1 pKi = 6.1 Binding
Binding affinity to human adrenergic alpha2B receptorBinding affinity to human adrenergic alpha2B receptor
ChEMBL 366 6 1 6 2.8 CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 10.1021/jm100668r
44289035 107290 0 None -407 7 Human 6.1 pKi = 6.1 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 524 7 1 4 4.4 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
CHEMBL291166 107290 0 None -407 7 Human 6.1 pKi = 6.1 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 524 7 1 4 4.4 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
11108001 17644 2 None -69 6 Human 6.1 pKi = 6.1 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL117248 17644 2 None -69 6 Human 6.1 pKi = 6.1 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL540542 17644 2 None -69 6 Human 6.1 pKi = 6.1 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
1960 9632 67 None -4 26 Rat 7.1 pKi = 7.1 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960012o
439260 9632 67 None -4 26 Rat 7.1 pKi = 7.1 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960012o
505 9632 67 None -4 26 Rat 7.1 pKi = 7.1 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960012o
CHEMBL1437 9632 67 None -4 26 Rat 7.1 pKi = 7.1 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960012o
DB00368 9632 67 None -4 26 Rat 7.1 pKi = 7.1 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960012o
CHEMBL179334 70077 0 None -4265 6 Human 6.1 pKi = 6.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 6.4 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)[C@H]1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
24882007 19245 1 None -1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting
ChEMBL 201 1 2 3 0.3 c1ccc2c(c1)cnn2N=C1NCCN1 10.1016/j.ejmech.2014.09.083
CHEMBL1186220 19245 1 None -1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting
ChEMBL 201 1 2 3 0.3 c1ccc2c(c1)cnn2N=C1NCCN1 10.1016/j.ejmech.2014.09.083
10575254 213662 0 None -63 4 Rat 7.1 pKi = 7.1 Binding
The compound's binding affinity against Alpha-2B adrenergic receptor from rat kidney homogenate in the presence of phentolamineThe compound's binding affinity against Alpha-2B adrenergic receptor from rat kidney homogenate in the presence of phentolamine
ChEMBL 443 8 1 5 4.1 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1021/jm970166j
CHEMBL90746 213662 0 None -63 4 Rat 7.1 pKi = 7.1 Binding
The compound's binding affinity against Alpha-2B adrenergic receptor from rat kidney homogenate in the presence of phentolamineThe compound's binding affinity against Alpha-2B adrenergic receptor from rat kidney homogenate in the presence of phentolamine
ChEMBL 443 8 1 5 4.1 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1021/jm970166j
5029 22317 92 None -13 4 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 359 8 1 5 3.0 COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C nan
CHEMBL1219 22317 92 None -13 4 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 359 8 1 5 3.0 COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C nan
72947315 99264 0 None -10 4 Human 6.1 pKi = 6.1 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 232 5 1 4 1.6 c1ccc(OC2CC2)c(OCC2=NCCN2)c1 10.1021/ml400232p
CHEMBL2431280 99264 0 None -10 4 Human 6.1 pKi = 6.1 Binding
Binding affinity at human alpha2B ARBinding affinity at human alpha2B AR
ChEMBL 232 5 1 4 1.6 c1ccc(OC2CC2)c(OCC2=NCCN2)c1 10.1021/ml400232p
9809007 179343 8 None -1047 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL448620 179343 8 None -1047 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
44579186 188755 0 None -2 3 Human 8.1 pKi = 8.1 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 474 8 1 7 3.1 O=C(NCCN1CCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1 10.1016/j.bmcl.2008.08.055
CHEMBL478026 188755 0 None -2 3 Human 8.1 pKi = 8.1 Binding
Binding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2B receptor expressed in CHO cells by radioligand binding assay
ChEMBL 474 8 1 7 3.1 O=C(NCCN1CCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1 10.1016/j.bmcl.2008.08.055
2142 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
4920903 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
502 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
5775 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
CHEMBL597 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
DB00692 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
2803 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm960012o
516 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm960012o
704 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm960012o
CHEMBL134 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm960012o
DB00575 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm960012o
2803 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm960359r
516 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm960359r
704 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm960359r
CHEMBL134 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm960359r
DB00575 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 10.1021/jm960359r
16655023 114218 2 None -5 7 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
CHEMBL318235 114218 2 None -5 7 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cells
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
2284 9956 33 None -3 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
4926 9956 33 None -3 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
7281 9956 33 None -3 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
CHEMBL564 9956 33 None -3 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
DB00420 9956 33 None -3 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
185076 193869 5 None -2 7 Human 8.1 pKi = 8.1 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2B adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL49137 193869 5 None -2 7 Human 8.1 pKi = 8.1 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2B adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
129211 10521 78 None -102 16 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligandBinding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
2562 10521 78 None -102 16 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligandBinding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
488 10521 78 None -102 16 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligandBinding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
CHEMBL836 10521 78 None -102 16 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligandBinding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
DB00706 10521 78 None -102 16 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligandBinding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
9809007 179343 8 None -1047 6 Human 6.1 pKi = 6.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
CHEMBL448620 179343 8 None -1047 6 Human 6.1 pKi = 6.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
24841480 190678 0 None -398 20 Human 6.1 pKi = 6.1 Binding
Antagonist activity at adrenergic alpha2B receptor (unknown origin) by PDSP assayAntagonist activity at adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 340 3 0 4 4.5 O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21 10.1016/j.bmcl.2013.04.082
CHEMBL481153 190678 0 None -398 20 Human 6.1 pKi = 6.1 Binding
Antagonist activity at adrenergic alpha2B receptor (unknown origin) by PDSP assayAntagonist activity at adrenergic alpha2B receptor (unknown origin) by PDSP assay
ChEMBL 340 3 0 4 4.5 O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21 10.1016/j.bmcl.2013.04.082
44438152 100383 0 None -42 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 459 7 0 6 5.7 COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1 10.1016/j.bmcl.2006.12.094
CHEMBL246639 100383 0 None -42 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 459 7 0 6 5.7 COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1 10.1016/j.bmcl.2006.12.094
2683 109665 25 None -112 16 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL305906 109665 25 None -112 16 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL334255 109665 25 None -112 16 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
11186227 91497 0 None -23 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1ccc(O)cc1)C1=NCCN1 10.1021/jm0408215
CHEMBL222798 91497 0 None -23 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 282 4 2 4 2.8 CC(Oc1ccccc1-c1ccc(O)cc1)C1=NCCN1 10.1021/jm0408215
10176999 110331 21 None -47 3 Rat 7.1 pKi = 7.1 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 231 2 2 4 2.2 Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2 10.1021/jm9605142
CHEMBL308570 110331 21 None -47 3 Rat 7.1 pKi = 7.1 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 231 2 2 4 2.2 Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2 10.1021/jm9605142
68617 212306 62 None -3 26 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 nan
CHEMBL1709 212306 62 None -3 26 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 nan
CHEMBL809 212306 62 None -3 26 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 nan
42574 22059 90 None -15 3 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 662 4 2 3 7.1 Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O nan
CHEMBL12131 22059 90 None -15 3 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 662 4 2 3 7.1 Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O nan
3823 56995 42 None -43 11 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
76973198 56995 42 None -43 11 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL157101 56995 42 None -43 11 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
10626982 118272 0 None -14 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 575 9 2 6 5.9 CC1=C(C#N)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL327775 118272 0 None -14 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 575 9 2 6 5.9 CC1=C(C#N)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
11300487 91777 0 None -17 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 280 4 1 3 3.4 Cc1ccccc1-c1ccccc1OC(C)C1=NCCN1 10.1021/jm0408215
CHEMBL223830 91777 0 None -17 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 280 4 1 3 3.4 Cc1ccccc1-c1ccccc1OC(C)C1=NCCN1 10.1021/jm0408215
237 211644 48 None -1 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL546257 211644 48 None -1 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL554190 211644 48 None -1 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL7568 211644 48 None -1 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
289 7030 12 None -75 14 Human 6.1 pKi = 6.1 Binding
Binding affinity to adrenergic alpha2B receptor by radioligand displacement assayBinding affinity to adrenergic alpha2B receptor by radioligand displacement assay
ChEMBL 301 8 0 2 4.9 CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C 10.1021/jm100697g
9948320 7030 12 None -75 14 Human 6.1 pKi = 6.1 Binding
Binding affinity to adrenergic alpha2B receptor by radioligand displacement assayBinding affinity to adrenergic alpha2B receptor by radioligand displacement assay
ChEMBL 301 8 0 2 4.9 CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C 10.1021/jm100697g
CHEMBL1242950 7030 12 None -75 14 Human 6.1 pKi = 6.1 Binding
Binding affinity to adrenergic alpha2B receptor by radioligand displacement assayBinding affinity to adrenergic alpha2B receptor by radioligand displacement assay
ChEMBL 301 8 0 2 4.9 CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C 10.1021/jm100697g
CHEMBL4520788 220754 10 None -39 25 Human 6.1 pKi = 6.1 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000743a ADRA2B
ChEMBL None None None CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1 10.6019/CHEMBL5212743
CHEMBL508338 195745 0 None -2 6 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL None None None None nan
11097789 109775 1 None -169 6 Human 6.1 pKi = 6.1 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 239 4 2 4 2.0 CSc1cc(F)ccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL306792 109775 1 None -169 6 Human 6.1 pKi = 6.1 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 239 4 2 4 2.0 CSc1cc(F)ccc1NCC1=NCCN1 10.1021/jm000542r
44312198 211368 0 None -3 4 Human 4.1 pKi = 4.1 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 292 1 1 5 2.2 Brc1c(NC2=NCCO2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL73164 211368 0 None -3 4 Human 4.1 pKi = 4.1 Binding
Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscineBinding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
ChEMBL 292 1 1 5 2.2 Brc1c(NC2=NCCO2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
44438167 155749 0 None -1071 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 505 7 1 7 3.8 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL394218 155749 0 None -1071 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 505 7 1 7 3.8 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2 10.1016/j.bmcl.2006.12.094
9809007 179343 8 None -1047 6 Human 6.1 pKi = 6.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
CHEMBL448620 179343 8 None -1047 6 Human 6.1 pKi = 6.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
12488 8438 56 None -12 23 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
941361 8438 56 None -12 23 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
CHEMBL30008 8438 56 None -12 23 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
DB04841 8438 56 None -12 23 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
4601 213526 35 None -3 17 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 269 6 0 2 3.7 Cc1ccccc1C(OCCN(C)C)c1ccccc1 nan
CHEMBL1201023 213526 35 None -3 17 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 269 6 0 2 3.7 Cc1ccccc1C(OCCN(C)C)c1ccccc1 nan
CHEMBL900 213526 35 None -3 17 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 269 6 0 2 3.7 Cc1ccccc1C(OCCN(C)C)c1ccccc1 nan
10531766 213776 0 None -776 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 607 9 2 7 6.3 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
CHEMBL91415 213776 0 None -776 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 607 9 2 7 6.3 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
57345627 77957 0 None -12 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 230 4 1 3 2.5 C=C(C)c1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956194 77957 0 None -12 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 230 4 1 3 2.5 C=C(C)c1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
57402717 77962 2 None -15 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 220 4 1 4 1.5 COc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL1956199 77962 2 None -15 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 220 4 1 4 1.5 COc1ccccc1OC(C)C1=NCCN1 10.1016/j.bmc.2012.01.035
24906197 194445 0 None -4 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 323 7 1 5 3.0 CC(Oc1ccccc1/C=N/OCc1ccccc1)C1=NCCN1 10.1021/jm800250z
CHEMBL495097 194445 0 None -4 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 323 7 1 5 3.0 CC(Oc1ccccc1/C=N/OCc1ccccc1)C1=NCCN1 10.1021/jm800250z
119584 9373 102 None -2 6 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl nan
1848 9373 102 None -2 6 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl nan
242 9373 102 None -2 6 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl nan
CHEMBL60889 9373 102 None -2 6 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl nan
DB11675 9373 102 None -2 6 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl nan
CHEMBL4777443 220825 0 None -41 14 Human 6.1 pKi = 6.1 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a ADRA2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000741a ADRA2B
ChEMBL None None None CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1 10.6019/CHEMBL5212743
10318507 65727 0 None -104 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 394 3 1 4 5.4 Cc1nc2cc(Cl)ccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
CHEMBL1689423 65727 0 None -104 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 394 3 1 4 5.4 Cc1nc2cc(Cl)ccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C 10.1021/jm060262x
10508016 213935 0 None -24 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 613 9 2 5 7.7 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2ccccc2c1 10.1021/jm980077m
CHEMBL92322 213935 0 None -24 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 613 9 2 5 7.7 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2ccccc2c1 10.1021/jm980077m
294234 109670 3 None -1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 182 1 1 3 1.7 C1CCCC(NC2=NCCO2)CC1 10.1016/0960-894X(94)85032-1
CHEMBL305928 109670 3 None -1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscine
ChEMBL 182 1 1 3 1.7 C1CCCC(NC2=NCCO2)CC1 10.1016/0960-894X(94)85032-1
49781006 24012 0 None -2 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 240 3 1 2 2.9 CCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
CHEMBL1256565 24012 0 None -2 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
ChEMBL 240 3 1 2 2.9 CCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1 10.1021/jm1006269
10032383 116887 0 None -870 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
136680387 116887 0 None -870 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL323579 116887 0 None -870 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-2b adrenergic receptorBinding affinity against human Alpha-2b adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
6518171 175075 55 None -8 8 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
CHEMBL434063 175075 55 None -8 8 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
10769331 118310 0 None -173 6 Human 7.0 pKi = 7.0 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 566 9 2 7 5.9 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(Cl)c([N+](=O)[O-])c1 10.1021/jm980077m
CHEMBL327931 118310 0 None -173 6 Human 7.0 pKi = 7.0 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 566 9 2 7 5.9 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(Cl)c([N+](=O)[O-])c1 10.1021/jm980077m
44292232 108098 0 None -3 3 Human 7.0 pKi = 7.0 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 222 3 1 3 2.2 CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1 10.1021/jm9905256
CHEMBL296660 108098 0 None -3 3 Human 7.0 pKi = 7.0 Binding
Inhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscineInhibitory constant against human Alpha-2B adrenergic receptor expressed in Y-1 cells using [3H]rauwolscine
ChEMBL 222 3 1 3 2.2 CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1 10.1021/jm9905256
11741010 90026 0 None -6 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 3 1 4 5.4 Cc1cc(C)c2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1 10.1021/jm060262x
CHEMBL218730 90026 0 None -6 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 388 3 1 4 5.4 Cc1cc(C)c2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1 10.1021/jm060262x
10841387 106394 0 None -257 6 Human 6.0 pKi = 6.0 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
CHEMBL284103 106394 0 None -257 6 Human 6.0 pKi = 6.0 Binding
Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor
ChEMBL 607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
10627021 113872 0 None -660 6 Human 6.0 pKi = 6.0 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 577 9 2 5 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C)cc1 10.1021/jm980077m
CHEMBL315914 113872 0 None -660 6 Human 6.0 pKi = 6.0 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 577 9 2 5 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C)cc1 10.1021/jm980077m
9904606 16158 0 None -10 4 Rat 6.0 pKi = 6.0 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 305 3 1 3 2.3 CN(c1cccc2c1CCCC2c1c[nH]cn1)S(C)(=O)=O 10.1021/jm030551a
CHEMBL111463 16158 0 None -10 4 Rat 6.0 pKi = 6.0 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 305 3 1 3 2.3 CN(c1cccc2c1CCCC2c1c[nH]cn1)S(C)(=O)=O 10.1021/jm030551a
CHEMBL4802042 220835 2 None - 1 Human 5.0 pKi = 5.0 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None COc1nc2ccc([C@@](O)(c3ccccc3)C3CCN(C(C)=O)CC3)cc2c(Cl)c1Cc1ccc(-n2cccn2)cc1 10.6019/CHEMBL4800728
CHEMBL4802042 220835 2 None - 1 Human 5.0 pKi = 5.0 Binding
GPCRScan assay: inhibition of Alpha2BGPCRScan assay: inhibition of Alpha2B
ChEMBL None None None COc1nc2ccc([C@@](O)(c3ccccc3)C3CCN(C(C)=O)CC3)cc2c(Cl)c1Cc1ccc(-n2cccn2)cc1 10.6019/CHEMBL4800728
13149 9323 36 None -154 17 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 398 5 1 5 3.8 CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC 10.1021/acs.jmedchem.9b01465
3034396 9323 36 None -154 17 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 398 5 1 5 3.8 CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC 10.1021/acs.jmedchem.9b01465
CHEMBL299031 9323 36 None -154 17 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 398 5 1 5 3.8 CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC 10.1021/acs.jmedchem.9b01465
135423051 84607 0 None -169 3 Human 5.0 pKi = 5.0 Binding
Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin
ChEMBL 391 4 1 5 2.5 COc1ccccc1N1CCN(C[C@@H]2CN=C3c4ccccc4NC(=O)N32)CC1 10.1021/jm970159v
CHEMBL2092926 84607 0 None -169 3 Human 5.0 pKi = 5.0 Binding
Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin
ChEMBL 391 4 1 5 2.5 COc1ccccc1N1CCN(C[C@@H]2CN=C3c4ccccc4NC(=O)N32)CC1 10.1021/jm970159v
10632290 211525 5 None -3 3 Rat 5.0 pKi = 5.0 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 211 2 2 4 2.1 c1c[nH]c(Nc2ccc3nccnc3c2)n1 10.1021/jm9605142
CHEMBL74449 211525 5 None -3 3 Rat 5.0 pKi = 5.0 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
ChEMBL 211 2 2 4 2.1 c1c[nH]c(Nc2ccc3nccnc3c2)n1 10.1021/jm9605142
10841387 106394 0 None -257 6 Human 6.0 pKi = 6.0 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL284103 106394 0 None -257 6 Human 6.0 pKi = 6.0 Binding
Binding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2B adrenergic receptor
ChEMBL 607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
44269089 103780 0 None -12 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 232 4 1 3 2.6 CC(Oc1ccccc1C(C)C)C1=NCCN1 10.1016/j.bmc.2012.01.035
CHEMBL266613 103780 0 None -12 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
ChEMBL 232 4 1 3 2.6 CC(Oc1ccccc1C(C)C)C1=NCCN1 10.1016/j.bmc.2012.01.035
11265631 143187 0 None -14 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 10.1021/jm061487a
CHEMBL373535 143187 0 None -14 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 10.1021/jm061487a
7059292 83075 7 None 3 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 194 1 1 2 2.9 Clc1ccccc1NC1=NCCC1 10.1016/j.bmc.2012.06.008
CHEMBL2058633 83075 7 None 3 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
ChEMBL 194 1 1 2 2.9 Clc1ccccc1NC1=NCCC1 10.1016/j.bmc.2012.06.008
11265631 143187 0 None -14 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 10.1021/jm0408215
CHEMBL373535 143187 0 None -14 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha-2B receptor expressed in CHO cells
ChEMBL 267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1 10.1021/jm0408215
10474335 201471 23 None -323 10 Human 5.0 pKi = 5.0 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 370 6 0 3 4.8 COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1 10.1038/s41586-020-2286-9
CHEMBL53325 201471 23 None -323 10 Human 5.0 pKi = 5.0 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
ChEMBL 370 6 0 3 4.8 COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1 10.1038/s41586-020-2286-9
9837106 110934 2 None -35 4 Human 6.0 pKi = 6.0 Binding
Tested for Binding affinity towards alpha-2B adrenergic receptorTested for Binding affinity towards alpha-2B adrenergic receptor
ChEMBL 202 1 1 2 2.8 C1=C(c2c[nH]cn2)c2sccc2CC1 10.1021/jm990569e
CHEMBL30955 110934 2 None -35 4 Human 6.0 pKi = 6.0 Binding
Tested for Binding affinity towards alpha-2B adrenergic receptorTested for Binding affinity towards alpha-2B adrenergic receptor
ChEMBL 202 1 1 2 2.8 C1=C(c2c[nH]cn2)c2sccc2CC1 10.1021/jm990569e
9837106 110934 2 None -35 4 Rat 6.0 pKi = 6.0 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 202 1 1 2 2.8 C1=C(c2c[nH]cn2)c2sccc2CC1 10.1021/jm000128r
CHEMBL30955 110934 2 None -35 4 Rat 6.0 pKi = 6.0 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 202 1 1 2 2.8 C1=C(c2c[nH]cn2)c2sccc2CC1 10.1021/jm000128r
11225732 100432 0 None -53 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 497 6 0 5 6.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2 10.1016/j.bmcl.2006.12.094
CHEMBL246852 100432 0 None -53 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsDisplacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells
ChEMBL 497 6 0 5 6.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2 10.1016/j.bmcl.2006.12.094
11777109 123745 0 None -31 2 Rat 7.0 pKi = 7.0 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 254 0 1 2 2.9 Clc1cc(Cl)c2c(c1)CC1(CC2)CN=CN1 10.1021/jm00020a021
CHEMBL338683 123745 0 None -31 2 Rat 7.0 pKi = 7.0 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 254 0 1 2 2.9 Clc1cc(Cl)c2c(c1)CC1(CC2)CN=CN1 10.1021/jm00020a021
44324737 214017 0 None -12 5 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL92860 214017 0 None -12 5 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2 10.1016/s0960-894x(03)00525-0
24906200 199935 0 None -4 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 328 5 1 3 4.5 c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1 10.1021/jm800250z
CHEMBL523048 199935 0 None -4 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
ChEMBL 328 5 1 3 4.5 c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1 10.1021/jm800250z
44288769 107925 0 None -870 7 Human 6.0 pKi = 6.0 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 542 7 1 4 4.5 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
CHEMBL295395 107925 0 None -870 7 Human 6.0 pKi = 6.0 Binding
In vivo inhibitory effect against alpha-2b Adrenergic receptorIn vivo inhibitory effect against alpha-2b Adrenergic receptor
ChEMBL 542 7 1 4 4.5 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
16090621 148353 0 None -2 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 422 5 1 4 5.6 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1Cc1ccccc1 10.1021/jm060262x
CHEMBL384925 148353 0 None -2 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells
ChEMBL 422 5 1 4 5.6 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1Cc1ccccc1 10.1021/jm060262x
3151 8244 97 None -97 26 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
945 8244 97 None -97 26 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
965 8244 97 None -97 26 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
CHEMBL219916 8244 97 None -97 26 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
DB01184 8244 97 None -97 26 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
10934575 211265 0 None -56 6 Human 6.0 pKi = 6.0 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 235 4 2 4 2.1 CSc1ccc(C)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72441 211265 0 None -56 6 Human 6.0 pKi = 6.0 Binding
Affinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2B adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
ChEMBL 235 4 2 4 2.1 CSc1ccc(C)cc1NCC1=NCCN1 10.1021/jm000542r
9838192 118089 18 None -5 6 Rat 6.0 pKi = 6.0 Binding
Binding affinity to Rattus norvegicus (rat) alpha2B receptor isolated from neonatal lungBinding affinity to Rattus norvegicus (rat) alpha2B receptor isolated from neonatal lung
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1007/s00044-004-0020-z
CHEMBL326702 118089 18 None -5 6 Rat 6.0 pKi = 6.0 Binding
Binding affinity to Rattus norvegicus (rat) alpha2B receptor isolated from neonatal lungBinding affinity to Rattus norvegicus (rat) alpha2B receptor isolated from neonatal lung
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1007/s00044-004-0020-z
9838192 118089 18 None -5 6 Rat 6.0 pKi = 6.0 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1021/jm030551a
CHEMBL326702 118089 18 None -5 6 Rat 6.0 pKi = 6.0 Binding
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assayIn vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1021/jm030551a
124087 8171 114 None -28 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 nan
7157 8171 114 None -28 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 nan
814 8171 114 None -28 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 nan
CHEMBL1172 8171 114 None -28 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 nan
DB00967 8171 114 None -28 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 nan
126720252 171454 0 None -34 12 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]Rauwolscine from human adrenergic alpha2B receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human adrenergic alpha2B receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method
ChEMBL 697 15 2 6 9.2 NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1 10.1021/acs.jmedchem.8b00168
CHEMBL4216870 171454 0 None -34 12 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]Rauwolscine from human adrenergic alpha2B receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human adrenergic alpha2B receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method
ChEMBL 697 15 2 6 9.2 NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1 10.1021/acs.jmedchem.8b00168
9815633 106411 3 None -25 6 Human 7.0 pKi = 7 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 204 1 1 2 2.9 c1nc(C2CCCc3sccc32)c[nH]1 10.1021/jm990569e
CHEMBL284213 106411 3 None -25 6 Human 7.0 pKi = 7 Binding
Binding affinity towards Alpha-2B adrenergic receptorBinding affinity towards Alpha-2B adrenergic receptor
ChEMBL 204 1 1 2 2.9 c1nc(C2CCCc3sccc32)c[nH]1 10.1021/jm990569e
10036255 28131 0 None -1 2 Rat 7.0 pKi = 7 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 216 1 1 3 1.6 COc1cccc2c1CC1(CC2)CN=CN1 10.1021/jm00020a021
CHEMBL131417 28131 0 None -1 2 Rat 7.0 pKi = 7 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 216 1 1 3 1.6 COc1cccc2c1CC1(CC2)CN=CN1 10.1021/jm00020a021
10036256 30553 0 None -1 2 Rat 7.0 pKi = 7 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 216 1 1 3 1.6 COc1ccc2c(c1)CC1(CC2)CN=CN1 10.1021/jm00020a021
CHEMBL133579 30553 0 None -1 2 Rat 7.0 pKi = 7 Binding
Binding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligandBinding affinity towards Alpha-2B adrenergic receptor in neonatal rat lung using [3H]-RX-821002 as radioligand
ChEMBL 216 1 1 3 1.6 COc1ccc2c(c1)CC1(CC2)CN=CN1 10.1021/jm00020a021
9815633 106411 3 None -25 6 Rat 7.0 pKi = 7 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 204 1 1 2 2.9 c1nc(C2CCCc3sccc32)c[nH]1 10.1021/jm000128r
CHEMBL284213 106411 3 None -25 6 Rat 7.0 pKi = 7 Binding
in vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2B adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
ChEMBL 204 1 1 2 2.9 c1nc(C2CCCc3sccc32)c[nH]1 10.1021/jm000128r
10101373 19865 0 None -19 2 Human 6.0 pKi = 6 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 718 6 6 6 4.6 O=C(NCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL1190317 19865 0 None -19 2 Human 6.0 pKi = 6 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 718 6 6 6 4.6 O=C(NCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
CHEMBL540594 19865 0 None -19 2 Human 6.0 pKi = 6 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
ChEMBL 718 6 6 6 4.6 O=C(NCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 10.1016/s0960-894x(00)00068-8
44324900 213677 0 None -11 3 Human 6.0 pKi = 6 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 423 6 0 7 2.6 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
CHEMBL90843 213677 0 None -11 3 Human 6.0 pKi = 6 Binding
In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscine
ChEMBL 423 6 0 7 2.6 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccccc4)CC3)C1CO2 10.1016/s0960-894x(03)00525-0
1816 9318 102 None -851 18 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
Drug Central 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
4205 9318 102 None -851 18 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
Drug Central 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
7241 9318 102 None -851 18 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
Drug Central 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
CHEMBL654 9318 102 None -851 18 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
Drug Central 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
DB00370 9318 102 None -851 18 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
Drug Central 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
108094 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 35224877
108094 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 7908642
108094 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 8819505
526 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 35224877
526 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 7908642
526 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 8819505
528 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 35224877
528 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 7908642
528 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 8819505
CHEMBL10332 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 35224877
CHEMBL10332 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 7908642
CHEMBL10332 10196 27 None -6 4 Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 8819505
136 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 1353247
136 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 35224877
136 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8819505
223 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 1353247
223 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 35224877
223 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8819505
643606 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 1353247
643606 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 35224877
643606 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8819505
CHEMBL10347 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 1353247
CHEMBL10347 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 35224877
CHEMBL10347 10065 32 None -5 16 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8819505
1588 9105 27 3H-RX821002 -1 44 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 3H-RX821002 -1 44 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 3H-RX821002 -1 44 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 3H-RX821002 -1 44 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 3H-RX821002 -1 44 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5268 10428 40 3H-RAUWOLSCINE -3 18 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
53 10428 40 3H-RAUWOLSCINE -3 18 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
CHEMBL300555 10428 40 3H-RAUWOLSCINE -3 18 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
None 222807 0 3H-RAUWOLSCINE -8 3 Rat 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 339 0 0 3 3.3 CN1CCC2(CCN3CCC4=C(C3C2)OC5=CC=CC=C45)N(C1=O)C None
5268 10428 40 3H-RAUWOLSCINE 1 18 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
53 10428 40 3H-RAUWOLSCINE 1 18 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
CHEMBL300555 10428 40 3H-RAUWOLSCINE 1 18 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
138107169 222731 0 3H-RAUWOLSCINE -5 23 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
22831402 222731 0 3H-RAUWOLSCINE -5 23 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
5268 10428 40 3H-RAUWOLSCINE 1 18 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
53 10428 40 3H-RAUWOLSCINE 1 18 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
CHEMBL300555 10428 40 3H-RAUWOLSCINE 1 18 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
138107169 222731 0 3H-RAUWOLSCINE -5 23 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
22831402 222731 0 3H-RAUWOLSCINE -5 23 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
2601 10552 33 3H-RX821002 -1 21 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
443951 10552 33 3H-RX821002 -1 21 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
56 10552 33 3H-RX821002 -1 21 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL73151 10552 33 3H-RX821002 -1 21 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
DB13399 10552 33 3H-RX821002 -1 21 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
138107169 222731 0 3H-RAUWOLSCINE -17 23 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
22831402 222731 0 3H-RAUWOLSCINE -17 23 Rat 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
None 222808 0 3H-RAUWOLSCINE -3 3 Rat 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 953 28 10 12 0.9 CCOC1=CC=C(C=C1)CC(C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C(C)C)C(=O)NC(CC(=O)N)C(=O)NC(C=S)C(=O)NC(CCCCN)C(=O)N)NC(=O)CC3(CCCCC3)S None
46780481 114308 20 3H-RAUWOLSCINE -20 53 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 114308 20 3H-RAUWOLSCINE -20 53 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 114308 20 3H-RAUWOLSCINE -20 53 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 114308 20 3H-RAUWOLSCINE -20 53 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL1196898 222809 0 3H-RAUWOLSCINE -2 3 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 248 3 1 5 1.2 CCOC1(COC2=CC=CC=C2O1)C3=NCCN3 None
12576 7302 94 3H-RAUWOLSCINE 2 6 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 None
71310 7302 94 3H-RAUWOLSCINE 2 6 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 None
CHEMBL353972 7302 94 3H-RAUWOLSCINE 2 6 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 None
DB11481 7302 94 3H-RAUWOLSCINE 2 6 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 None
None 222740 0 3H-RAUWOLSCINE -1 5 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 295 5 2 3 3.0 C1CC2=CC=CC=C2C(=O)C1CNCCC3=CC=C(C=C3)O None
102 10899 48 3H-RAUWOLSCINE -10 49 Human 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
102 10899 48 3H-RAUWOLSCINE -10 49 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-RAUWOLSCINE -10 49 Human 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-RAUWOLSCINE -10 49 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-RAUWOLSCINE -10 49 Human 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-RAUWOLSCINE -10 49 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-RAUWOLSCINE -10 49 Human 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-RAUWOLSCINE -10 49 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-RAUWOLSCINE -10 49 Human 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-RAUWOLSCINE -10 49 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
102 10899 48 3H-RAUWOLSCINE -10 49 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-RAUWOLSCINE -10 49 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-RAUWOLSCINE -10 49 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-RAUWOLSCINE -10 49 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-RAUWOLSCINE -10 49 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
102 10899 48 3H-RAUWOLSCINE -10 49 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-RAUWOLSCINE -10 49 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-RAUWOLSCINE -10 49 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-RAUWOLSCINE -10 49 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-RAUWOLSCINE -10 49 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
138107169 222731 0 35S-GTPGammaS -5 23 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
22831402 222731 0 35S-GTPGammaS -5 23 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
41 8440 0 3H-RX821002 1 17 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 195 0 1 3 0.9 Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 None
72036 8440 0 3H-RX821002 1 17 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 195 0 1 3 0.9 Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 None
CHEMBL1765294 8440 0 3H-RX821002 1 17 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 195 0 1 3 0.9 Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 None
164512323 222810 0 3H-RAUWOLSCINE -12 5 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 352 1 1 4 3.2 CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 None
6419959 222810 0 3H-RAUWOLSCINE -12 5 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 352 1 1 4 3.2 CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 None
5268 10428 40 3H-MK912 -3 18 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
53 10428 40 3H-MK912 -3 18 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
CHEMBL300555 10428 40 3H-MK912 -3 18 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
122211 7250 0 3H-RAUWOLSCINE 6 6 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C None
524 7250 0 3H-RAUWOLSCINE 6 6 Rat 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C None
108094 10196 27 35S-GTPGammaS -6 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 None
526 10196 27 35S-GTPGammaS -6 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 None
528 10196 27 35S-GTPGammaS -6 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 None
CHEMBL10332 10196 27 35S-GTPGammaS -6 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 None
5268 10428 40 3H-RAUWOLSCINE -3 18 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
53 10428 40 3H-RAUWOLSCINE -3 18 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
CHEMBL300555 10428 40 3H-RAUWOLSCINE -3 18 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 None
123981 23231 22 3H-RAUWOLSCINE 2 8 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1 None
CHEMBL123349 23231 22 3H-RAUWOLSCINE 2 8 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1 None
CHEMBL536803 23231 22 3H-RAUWOLSCINE 2 8 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1 None
None 222738 0 3H-RAUWOLSCINE -2 6 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 358 4 0 3 2.8 CCCS(=O)(=O)N(C)C1CCN2CCC3=CC=CC=C3C2C1.Cl None
102 10899 48 3H-RX821002 -10 49 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-RX821002 -10 49 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-RX821002 -10 49 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-RX821002 -10 49 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-RX821002 -10 49 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
2142 9870 58 3H-RX821002 -5 37 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
4920903 9870 58 3H-RX821002 -5 37 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
502 9870 58 3H-RX821002 -5 37 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
5775 9870 58 3H-RX821002 -5 37 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
CHEMBL597 9870 58 3H-RX821002 -5 37 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
DB00692 9870 58 3H-RX821002 -5 37 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
46780481 114308 20 3H-CLONIDINE -20 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 114308 20 3H-CLONIDINE -20 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 114308 20 3H-CLONIDINE -20 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 114308 20 3H-CLONIDINE -20 53 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
12575 8769 30 UNDEFINED -53 17 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
54459 8769 30 UNDEFINED -53 17 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
CHEMBL10316 8769 30 UNDEFINED -53 17 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
138107169 222731 0 3H-RAUWOLSCINE -17 23 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
22831402 222731 0 3H-RAUWOLSCINE -17 23 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
202 8290 77 UNDEFINED -9 33 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 UNDEFINED -9 33 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 UNDEFINED -9 33 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 UNDEFINED -9 33 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 UNDEFINED -9 33 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
5656 209845 87 UNDEFINED -7 43 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 209845 87 UNDEFINED -7 43 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 209906 52 UNDEFINED -1 30 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 209906 52 UNDEFINED -1 30 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
165193 222724 0 3H-RAUWOLSCINE -4265 30 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 259 6 2 3 2.6 CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O None
62882 222724 0 3H-RAUWOLSCINE -4265 30 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 259 6 2 3 2.6 CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O None
66366 222724 0 3H-RAUWOLSCINE -4265 30 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 259 6 2 3 2.6 CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O None
243 9976 91 3H-RAUWOLSCINE -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 9976 91 3H-RAUWOLSCINE -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 9976 91 3H-RAUWOLSCINE -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 9976 91 3H-RAUWOLSCINE -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 9976 91 3H-RAUWOLSCINE -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
183782 10171 20 3H-RAUWOLSCINE -2398 14 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 8 1 4 4.4 CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N None
237 10171 20 3H-RAUWOLSCINE -2398 14 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 8 1 4 4.4 CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N None
CHEMBL85251 10171 20 3H-RAUWOLSCINE -2398 14 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 8 1 4 4.4 CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N None
2662 18156 131 3H-CLONIDINE -1 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 None
CHEMBL118 18156 131 3H-CLONIDINE -1 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 None
5090 22333 106 3H-CLONIDINE -1348 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 0 4 2.6 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 None
CHEMBL122 22333 106 3H-CLONIDINE -1348 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 0 4 2.6 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 None
156391 53574 99 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
CHEMBL1200806 53574 99 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
CHEMBL154 53574 99 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
10624 77075 19 125I-Clonidine -776 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
138543650 77075 19 125I-Clonidine -776 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
CHEMBL194378 77075 19 125I-Clonidine -776 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
2244 101008 100 3H-CLONIDINE -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 180 2 1 3 1.3 CC(=O)Oc1ccccc1C(=O)O None
CHEMBL25 101008 100 3H-CLONIDINE -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 180 2 1 3 1.3 CC(=O)Oc1ccccc1C(=O)O None
3663 106743 83 3H-CLONIDINE -288 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 504 0 6 8 5.1 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 None
CHEMBL286494 106743 83 3H-CLONIDINE -288 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 504 0 6 8 5.1 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 None
5280343 195054 124 3H-CLONIDINE -147 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
CHEMBL1520590 195054 124 3H-CLONIDINE -147 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
CHEMBL50 195054 124 3H-CLONIDINE -147 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
3672 199312 136 3H-CLONIDINE -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 206 4 1 1 3.1 CC(C)Cc1ccc(C(C)C(=O)O)cc1 None
CHEMBL521 199312 136 3H-CLONIDINE -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 206 4 1 1 3.1 CC(C)Cc1ccc(C(C)C(=O)O)cc1 None
54676228 200394 112 3H-CLONIDINE -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 331 2 2 5 1.6 CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O None
CHEMBL527 200394 112 3H-CLONIDINE -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 331 2 2 5 1.6 CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O None
4495 203314 92 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 None
CHEMBL56367 203314 92 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 None
54677470 207330 115 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
CHEMBL1256873 207330 115 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
CHEMBL599 207330 115 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
5281600 209804 92 3H-CLONIDINE -275 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 538 3 6 10 5.1 O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 None
CHEMBL63354 209804 92 3H-CLONIDINE -275 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 538 3 6 10 5.1 O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 None
4054 212280 72 125I-Clonidine -1 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
CHEMBL1699 212280 72 125I-Clonidine -1 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
CHEMBL807 212280 72 125I-Clonidine -1 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
119607 212982 113 3H-CLONIDINE -97 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 None
CHEMBL865 212982 113 3H-CLONIDINE -97 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 None
None 222772 0 3H-RAUWOLSCINE -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 329 2 0 4 3.6 CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl None
104911 222798 0 3H-CLONIDINE -41686 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 530 7 0 5 5.1 COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl None
None 222806 0 3H-RAUWOLSCINE -6309 13 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 453 9 2 6 2.6 COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl None
25137849 222958 0 3H-CLONIDINE -1 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
71290 222958 0 3H-CLONIDINE -1 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
None 223018 0 3H-CLONIDINE -89125 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 316 7 3 3 3.0 CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O None
None 223090 0 3H-CLONIDINE -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 240 7 4 6 -0.8 C(C(C(=O)O)N)SSCC(C(=O)O)N None
None 223091 0 3H-CLONIDINE -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 149 4 2 3 0.2 CSCCC(C(=O)O)N None
None 223092 0 3H-CLONIDINE -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 135 3 3 3 -0.3 C(CS)C(C(=O)O)N None
None 223093 0 3H-CLONIDINE -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 121 2 3 3 -0.7 C(C(C(=O)O)N)S None
None 223094 0 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 117 0 1 3 -0.0 C1CSC(=O)C1N None
None 223095 0 3H-CLONIDINE -1 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 3 3 3 -1.4 C(C(C(=O)O)N)S(=O)O None
None 223097 0 3H-CLONIDINE -1 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 4 3 4 -1.3 C(CS(=O)(=O)O)C(C(=O)O)N None
None 223106 0 3H-CLONIDINE -16 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 536 11 1 4 9.0 CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C None
4978 223107 0 3H-CLONIDINE -7 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 520 1 7 9 4.3 CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O None
None 223108 0 3H-CLONIDINE -3 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 464 4 8 12 -0.6 C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O None
None 223109 0 3H-CLONIDINE -281 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 610 6 10 16 -1.7 CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O None
None 223110 0 3H-CLONIDINE -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 448 3 7 11 0.4 CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O None
None 223121 0 3H-RX821002 -1862 19 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 246 2 1 4 1.6 CCCN1CCCC2C1CC3=CN=C(N=C3C2)N None
135269 223168 0 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 222 5 1 3 2.5 CCCCC(=O)OC1=CC=CC=C1C(=O)O None
23681059 223169 0 3H-CLONIDINE -1 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O None
5018304 223170 0 3H-CLONIDINE -1 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 317 4 1 3 0.0 C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] None
84003 223171 0 3H-CLONIDINE -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 376 6 5 7 -0.0 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O None
123619 223172 0 3H-CLONIDINE -1412 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 358 3 0 4 4.2 CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl None
119828 223173 0 3H-CLONIDINE -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 370 5 1 5 3.5 CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C None
None 223174 0 3H-CLONIDINE -7 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 517 8 2 5 5.2 CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C None
None 223268 0 3H-CLONIDINE -4570 26 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 347 6 0 3 5.0 CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3 None
242 7258 124 3H-CLONIDINE -64 51 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-CLONIDINE -64 51 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-CLONIDINE -64 51 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-CLONIDINE -64 51 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-CLONIDINE -64 51 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
1343 8670 62 3H-MK912 -91 9 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
3519 8670 62 3H-MK912 -91 9 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
522 8670 62 3H-MK912 -91 9 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
CHEMBL862 8670 62 3H-MK912 -91 9 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
DB01018 8670 62 3H-MK912 -91 9 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
242 7258 124 3H-CLONIDINE -64 51 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-CLONIDINE -64 51 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-CLONIDINE -64 51 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-CLONIDINE -64 51 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-CLONIDINE -64 51 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
209 9831 97 3H-CLONIDINE -38 23 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
2113 9831 97 3H-CLONIDINE -38 23 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4748 9831 97 3H-CLONIDINE -38 23 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL567 9831 97 3H-CLONIDINE -38 23 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00850 9831 97 3H-CLONIDINE -38 23 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
3658 10879 53 35S-GTPGammaS -114 8 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C None
517 10879 53 35S-GTPGammaS -114 8 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C None
5709 10879 53 35S-GTPGammaS -114 8 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C None
CHEMBL312448 10879 53 35S-GTPGammaS -114 8 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C None
DB06694 10879 53 35S-GTPGammaS -114 8 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C None
7153 104796 77 3H-CLONIDINE -5 33 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
CHEMBL272942 104796 77 3H-CLONIDINE -5 33 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
134 9292 24 3H-CLONIDINE -93 67 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-CLONIDINE -93 67 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-CLONIDINE -93 67 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-CLONIDINE -93 67 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-CLONIDINE -93 67 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1613 9127 53 3H-CLONIDINE -7 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 3H-CLONIDINE -7 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 3H-CLONIDINE -7 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 3H-CLONIDINE -7 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 3H-CLONIDINE -7 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
2389 10104 118 3H-CLONIDINE -104 66 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-CLONIDINE -104 66 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-CLONIDINE -104 66 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-CLONIDINE -104 66 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-CLONIDINE -104 66 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
1613 9127 53 3H-CLONIDINE -7 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 3H-CLONIDINE -7 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 3H-CLONIDINE -7 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 3H-CLONIDINE -7 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 3H-CLONIDINE -7 44 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
2389 10104 118 3H-CLONIDINE -104 66 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-CLONIDINE -104 66 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-CLONIDINE -104 66 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-CLONIDINE -104 66 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-CLONIDINE -104 66 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
4209 9937 75 3H-RAUWOLSCINE -20 33 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 3H-RAUWOLSCINE -20 33 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 3H-RAUWOLSCINE -20 33 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 3H-RAUWOLSCINE -20 33 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 3H-RAUWOLSCINE -20 33 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 3H-RAUWOLSCINE -20 33 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
2695 10613 81 3H-RAUWOLSCINE -20 6 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
5504 10613 81 3H-RAUWOLSCINE -20 6 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
7310 10613 81 3H-RAUWOLSCINE -20 6 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
CHEMBL770 10613 81 3H-RAUWOLSCINE -20 6 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
DB00797 10613 81 3H-RAUWOLSCINE -20 6 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
4209 9937 75 3H-MK912 -131 33 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 3H-MK912 -131 33 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 3H-MK912 -131 33 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 3H-MK912 -131 33 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 3H-MK912 -131 33 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 3H-MK912 -131 33 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
6852400 222716 0 3H-RAUWOLSCINE -30 22 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O None
73759726 222716 0 3H-RAUWOLSCINE -30 22 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O None
102 10899 48 3H-MK912 -10 49 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-MK912 -10 49 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-MK912 -10 49 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-MK912 -10 49 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-MK912 -10 49 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
44438168 100593 0 UNDEFINED -389 3 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 533 7 0 7 4.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2 None
CHEMBL247665 100593 0 UNDEFINED -389 3 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 533 7 0 7 4.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2 None
5524 223243 0 35S-GTPGammaS -1 4 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 215 1 2 3 1.9 C1CCC2=C(C1)C=CC=C2NC3=NCCN3 None
1343 8670 62 35S-GTPGammaS -91 9 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
3519 8670 62 35S-GTPGammaS -91 9 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
522 8670 62 35S-GTPGammaS -91 9 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
CHEMBL862 8670 62 35S-GTPGammaS -91 9 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
DB01018 8670 62 35S-GTPGammaS -91 9 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
15897 9637 0 3H-CLONIDINE -63 36 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
215 9637 0 3H-CLONIDINE -63 36 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
CHEMBL1979333 9637 0 3H-CLONIDINE -63 36 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
135 9310 43 3H-RAUWOLSCINE -13 56 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-RAUWOLSCINE -13 56 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-RAUWOLSCINE -13 56 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-RAUWOLSCINE -13 56 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-RAUWOLSCINE -13 56 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
164512323 222810 0 3H-RAUWOLSCINE -7 5 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 352 1 1 4 3.2 CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 None
6419959 222810 0 3H-RAUWOLSCINE -7 5 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 352 1 1 4 3.2 CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 None
4209 9937 75 3H-CLONIDINE -131 33 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 3H-CLONIDINE -131 33 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 3H-CLONIDINE -131 33 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 3H-CLONIDINE -131 33 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 3H-CLONIDINE -131 33 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 3H-CLONIDINE -131 33 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
1220 6975 55 3H-RAUWOLSCINE -117 44 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-RAUWOLSCINE -117 44 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-RAUWOLSCINE -117 44 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-RAUWOLSCINE -117 44 Rat 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
None 223486 0 UNDEFINED -8 3 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 390 1 2 4 3.1 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl None
44438166 100592 0 UNDEFINED -371 3 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 467 8 2 7 3.5 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2 None
CHEMBL247664 100592 0 UNDEFINED -371 3 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 467 8 2 7 3.5 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2 None
1576 223105 0 3H-CLONIDINE -2 40 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 163 3 1 2 1.5 CC(C(=O)C1=CC=CC=C1)NC None
102 10899 48 3H-RX821002 -10 49 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-RX821002 -10 49 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-RX821002 -10 49 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-RX821002 -10 49 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-RX821002 -10 49 Rat 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
931 223242 0 35S-GTPGammaS -5 4 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 128 0 0 0 2.8 C1=CC=C2C=CC=CC2=C1 None
11750482 154199 0 UNDEFINED -19 3 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 419 6 0 6 5.3 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2 None
CHEMBL392991 154199 0 UNDEFINED -19 3 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 419 6 0 6 5.3 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2 None
3294 8787 111 3H-RX821002 -47 44 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 3H-RX821002 -47 44 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 3H-RX821002 -47 44 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 3H-RX821002 -47 44 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 3H-RX821002 -47 44 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
3294 8787 111 3H-RX821002 -47 44 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 3H-RX821002 -47 44 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 3H-RX821002 -47 44 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 3H-RX821002 -47 44 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 3H-RX821002 -47 44 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
15897 9637 0 3H-CLONIDINE -63 36 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
215 9637 0 3H-CLONIDINE -63 36 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
CHEMBL1979333 9637 0 3H-CLONIDINE -63 36 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
214 10632 58 3H-CLONIDINE -39 30 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2740 10632 58 3H-CLONIDINE -39 30 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5566 10632 58 3H-CLONIDINE -39 30 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
66064 10632 58 3H-CLONIDINE -39 30 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL422 10632 58 3H-CLONIDINE -39 30 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00831 10632 58 3H-CLONIDINE -39 30 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
None 222737 0 3H-RAUWOLSCINE -112 19 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 421 9 1 6 4.3 COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4 None
68712 107114 60 35S-GTPGammaS 1 5 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 None
CHEMBL289480 107114 60 35S-GTPGammaS 1 5 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 None
124 9755 47 35S-GTPGammaS -977 32 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2032 9755 47 35S-GTPGammaS -977 32 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
4636 9755 47 35S-GTPGammaS -977 32 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
CHEMBL762 9755 47 35S-GTPGammaS -977 32 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
DB00935 9755 47 35S-GTPGammaS -977 32 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
1615 174570 24 3H-CLONIDINE -4 44 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 193 3 1 3 1.6 CNC(C)Cc1ccc2c(c1)OCO2 None
CHEMBL43048 174570 24 3H-CLONIDINE -4 44 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 193 3 1 3 1.6 CNC(C)Cc1ccc2c(c1)OCO2 None
None 222814 0 3H-RAUWOLSCINE -2 3 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 200 3 1 1 2.8 CC1=C(C(=CC=C1)C)CCC2=CN=CN2 None
135398745 9688 112 3H-RAUWOLSCINE -37 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-RAUWOLSCINE -37 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-RAUWOLSCINE -37 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-RAUWOLSCINE -37 65 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
25137849 222958 0 3H-CLONIDINE -1 40 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
71290 222958 0 3H-CLONIDINE -1 40 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
122211 7250 0 3H-MK912 -6 6 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C None
524 7250 0 3H-MK912 -6 6 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C None
68602 211905 80 35S-GTPGammaS -3 8 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
CHEMBL77921 211905 80 35S-GTPGammaS -3 8 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
3337 213146 27 3H-CLONIDINE -14 40 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 3H-CLONIDINE -14 40 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 3H-CLONIDINE -14 40 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 3H-CLONIDINE -14 40 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 3H-CLONIDINE -14 40 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
1524 8962 96 3H-RAUWOLSCINE -27 51 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-RAUWOLSCINE -27 51 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-RAUWOLSCINE -27 51 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-RAUWOLSCINE -27 51 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-RAUWOLSCINE -27 51 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-RAUWOLSCINE -27 51 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
68602 211905 80 3H-RX821002 -3 8 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
CHEMBL77921 211905 80 3H-RX821002 -3 8 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
6040 222812 0 3H-RAUWOLSCINE -1 3 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 233 2 0 3 2.3 C1CCN(CC1)CC2COC3=CC=CC=C3O2 None
122211 7250 0 3H-RAUWOLSCINE -6 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C None
524 7250 0 3H-RAUWOLSCINE -6 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C None
44438165 173563 0 UNDEFINED -223 3 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 467 9 1 7 3.3 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2 None
CHEMBL428407 173563 0 UNDEFINED -223 3 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 467 9 1 7 3.3 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2 None
164512323 222810 0 3H-RAUWOLSCINE -12 5 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 352 1 1 4 3.2 CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 None
6419959 222810 0 3H-RAUWOLSCINE -12 5 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 352 1 1 4 3.2 CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 None
124 9755 47 3H-RAUWOLSCINE -977 32 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2032 9755 47 3H-RAUWOLSCINE -977 32 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
4636 9755 47 3H-RAUWOLSCINE -977 32 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
CHEMBL762 9755 47 3H-RAUWOLSCINE -977 32 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
DB00935 9755 47 3H-RAUWOLSCINE -977 32 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2726 7706 68 3H-RAUWOLSCINE -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-RAUWOLSCINE -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-RAUWOLSCINE -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-RAUWOLSCINE -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-RAUWOLSCINE -13 72 Rat 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
135398737 7745 93 3H-RAUWOLSCINE -9 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-RAUWOLSCINE -9 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-RAUWOLSCINE -9 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-RAUWOLSCINE -9 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-RAUWOLSCINE -9 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
1524 8962 96 3H-RAUWOLSCINE -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-RAUWOLSCINE -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-RAUWOLSCINE -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-RAUWOLSCINE -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-RAUWOLSCINE -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-RAUWOLSCINE -169 51 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
4209 9937 75 3H-RAUWOLSCINE -131 33 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 3H-RAUWOLSCINE -131 33 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 3H-RAUWOLSCINE -131 33 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 3H-RAUWOLSCINE -131 33 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 3H-RAUWOLSCINE -131 33 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 3H-RAUWOLSCINE -131 33 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
162265 209053 22 3H-CLONIDINE -16 44 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 209053 22 3H-CLONIDINE -16 44 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 209053 22 3H-CLONIDINE -16 44 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
3337 213146 27 3H-CLONIDINE -14 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 3H-CLONIDINE -14 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 3H-CLONIDINE -14 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 3H-CLONIDINE -14 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 3H-CLONIDINE -14 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
4158 212120 21 125I-Clonidine -1 21 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
CHEMBL1722 212120 21 125I-Clonidine -1 21 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
CHEMBL796 212120 21 125I-Clonidine -1 21 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
3337 213146 27 3H-CLONIDINE -14 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 3H-CLONIDINE -14 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 3H-CLONIDINE -14 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 3H-CLONIDINE -14 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 3H-CLONIDINE -14 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
15897 9637 0 3H-CLONIDINE -63 36 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
215 9637 0 3H-CLONIDINE -63 36 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
CHEMBL1979333 9637 0 3H-CLONIDINE -63 36 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
2726 7706 68 3H-RAUWOLSCINE -13 72 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-RAUWOLSCINE -13 72 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-RAUWOLSCINE -13 72 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-RAUWOLSCINE -13 72 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-RAUWOLSCINE -13 72 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
2 10035 23 3H-RX821002 -524 28 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 219 2 1 2 2.0 CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 None
54562 10035 23 3H-RX821002 -524 28 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 219 2 1 2 2.0 CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 None
CHEMBL240773 10035 23 3H-RX821002 -524 28 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 219 2 1 2 2.0 CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 None
1028 7079 71 3H-RAUWOLSCINE -128 30 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
139148732 7079 71 3H-RAUWOLSCINE -128 30 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
479 7079 71 3H-RAUWOLSCINE -128 30 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
5816 7079 71 3H-RAUWOLSCINE -128 30 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
CHEMBL679 7079 71 3H-RAUWOLSCINE -128 30 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
DB00668 7079 71 3H-RAUWOLSCINE -128 30 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
100 10577 58 3H-RAUWOLSCINE -125 54 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 3H-RAUWOLSCINE -125 54 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 3H-RAUWOLSCINE -125 54 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 3H-RAUWOLSCINE -125 54 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 3H-RAUWOLSCINE -125 54 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
135398737 7745 93 3H-CLONIDINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-CLONIDINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-CLONIDINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-CLONIDINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-CLONIDINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
2726 7706 68 3H-CLONIDINE -8 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-CLONIDINE -8 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-CLONIDINE -8 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-CLONIDINE -8 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-CLONIDINE -8 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
135398737 7745 93 3H-CLONIDINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737 7745 93 3H-RAUWOLSCINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-CLONIDINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-RAUWOLSCINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-CLONIDINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-RAUWOLSCINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-CLONIDINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-RAUWOLSCINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-CLONIDINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-RAUWOLSCINE -9 90 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135 9310 43 3H-RAUWOLSCINE -8 56 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-RAUWOLSCINE -8 56 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-RAUWOLSCINE -8 56 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-RAUWOLSCINE -8 56 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-RAUWOLSCINE -8 56 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
185 10778 60 3H-CLONIDINE -831 37 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
5311271 10778 60 3H-CLONIDINE -831 37 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
CHEMBL74355 10778 60 3H-CLONIDINE -831 37 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
DB16351 10778 60 3H-CLONIDINE -831 37 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
484 9633 51 35S-GTPGammaS -9 35 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
951 9633 51 35S-GTPGammaS -9 35 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
CHEMBL432 9633 51 35S-GTPGammaS -9 35 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
2726 7706 68 3H-CLONIDINE -8 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-CLONIDINE -8 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-CLONIDINE -8 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-CLONIDINE -8 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-CLONIDINE -8 72 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
3952 8669 38 35S-GTPGammaS -18 12 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
5353646 8669 38 35S-GTPGammaS -18 12 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
5443 8669 38 35S-GTPGammaS -18 12 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
5702063 8669 38 35S-GTPGammaS -18 12 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
CHEMBL1331786 8669 38 35S-GTPGammaS -18 12 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
CHEMBL420 8669 38 35S-GTPGammaS -18 12 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
2202 9906 96 3H-RX821002 -1 21 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
4850 9906 96 3H-RX821002 -1 21 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
49 9906 96 3H-RX821002 -1 21 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
CHEMBL1371770 9906 96 3H-RX821002 -1 21 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
DB12478 9906 96 3H-RX821002 -1 21 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
2216 7234 50 35S-GTPGammaS -2 6 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
229 7234 50 35S-GTPGammaS -2 6 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
7117 7234 50 35S-GTPGammaS -2 6 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
CHEMBL647 7234 50 35S-GTPGammaS -2 6 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
DB00964 7234 50 35S-GTPGammaS -2 6 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
124 9755 47 3H-MK912 -977 32 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2032 9755 47 3H-MK912 -977 32 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
4636 9755 47 3H-MK912 -977 32 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
CHEMBL762 9755 47 3H-MK912 -977 32 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
DB00935 9755 47 3H-MK912 -977 32 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
11293787 154992 0 UNDEFINED -27 3 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 447 6 0 5 5.8 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2 None
CHEMBL393597 154992 0 UNDEFINED -27 3 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 447 6 0 5 5.8 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2 None
2136 9869 30 3H-RAUWOLSCINE -3 6 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 None
4768 9869 30 3H-RAUWOLSCINE -3 6 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 None
7268 9869 30 3H-RAUWOLSCINE -3 6 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 None
CHEMBL753 9869 30 3H-RAUWOLSCINE -3 6 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 None
DB00925 9869 30 3H-RAUWOLSCINE -3 6 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 None
2142 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
4920903 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
502 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
5775 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
CHEMBL597 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
DB00692 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
108094 10196 27 3H-MK912 -6 4 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 None
526 10196 27 3H-MK912 -6 4 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 None
528 10196 27 3H-MK912 -6 4 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 None
CHEMBL10332 10196 27 3H-MK912 -6 4 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 None
4209 9937 75 3H-RAUWOLSCINE -131 33 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 3H-RAUWOLSCINE -131 33 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 3H-RAUWOLSCINE -131 33 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 3H-RAUWOLSCINE -131 33 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 3H-RAUWOLSCINE -131 33 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 3H-RAUWOLSCINE -131 33 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
124 9755 47 3H-RAUWOLSCINE -213 32 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2032 9755 47 3H-RAUWOLSCINE -213 32 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
4636 9755 47 3H-RAUWOLSCINE -213 32 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
CHEMBL762 9755 47 3H-RAUWOLSCINE -213 32 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
DB00935 9755 47 3H-RAUWOLSCINE -213 32 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2803 7742 58 35S-GTPGammaS -1 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 35S-GTPGammaS -1 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 35S-GTPGammaS -1 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 35S-GTPGammaS -1 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 35S-GTPGammaS -1 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
164512323 222810 0 3H-RAUWOLSCINE -12 5 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 352 1 1 4 3.2 CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 None
6419959 222810 0 3H-RAUWOLSCINE -12 5 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 352 1 1 4 3.2 CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 None
2695 10613 81 35S-GTPGammaS -69 6 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
5504 10613 81 35S-GTPGammaS -69 6 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
7310 10613 81 35S-GTPGammaS -69 6 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
CHEMBL770 10613 81 35S-GTPGammaS -69 6 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
DB00797 10613 81 35S-GTPGammaS -69 6 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
2105 9828 37 3H-RX821002 -8 32 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 3H-RX821002 -8 32 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 3H-RX821002 -8 32 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 3H-RX821002 -8 32 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 3H-RX821002 -8 32 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
1212 8443 50 3H-RAUWOLSCINE -645 65 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 3H-RAUWOLSCINE -645 65 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 3H-RAUWOLSCINE -645 65 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 3H-RAUWOLSCINE -645 65 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 3H-RAUWOLSCINE -645 65 Rat 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2142 9870 58 35S-GTPGammaS -5 37 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
4920903 9870 58 35S-GTPGammaS -5 37 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
502 9870 58 35S-GTPGammaS -5 37 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
5775 9870 58 35S-GTPGammaS -5 37 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
CHEMBL597 9870 58 35S-GTPGammaS -5 37 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
DB00692 9870 58 35S-GTPGammaS -5 37 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
68602 211905 80 35S-GTPGammaS -3 8 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
CHEMBL77921 211905 80 35S-GTPGammaS -3 8 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
44438148 100265 0 UNDEFINED -34 3 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 430 6 0 6 5.1 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2 None
CHEMBL246229 100265 0 UNDEFINED -34 3 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 430 6 0 6 5.1 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2 None
484 9633 51 35S-GTPGammaS -9 35 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
951 9633 51 35S-GTPGammaS -9 35 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
CHEMBL432 9633 51 35S-GTPGammaS -9 35 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
31101 7516 40 3H-RX821002 -33 35 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 3H-RX821002 -33 35 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 3H-RX821002 -33 35 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 3H-RX821002 -33 35 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 3H-RX821002 -33 35 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
100 10577 58 3H-CLONIDINE -35 54 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 3H-CLONIDINE -35 54 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 3H-CLONIDINE -35 54 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 3H-CLONIDINE -35 54 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 3H-CLONIDINE -35 54 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
100 10577 58 3H-CLONIDINE -35 54 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 3H-CLONIDINE -35 54 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 3H-CLONIDINE -35 54 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 3H-CLONIDINE -35 54 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 3H-CLONIDINE -35 54 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
523 10878 93 35S-GTPGammaS -1 5 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C None
5707 10878 93 35S-GTPGammaS -1 5 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C None
CHEMBL297362 10878 93 35S-GTPGammaS -1 5 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C None
DB11477 10878 93 35S-GTPGammaS -1 5 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C None
162265 209053 22 3H-CLONIDINE -16 44 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 209053 22 3H-CLONIDINE -16 44 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 209053 22 3H-CLONIDINE -16 44 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
2181 9902 46 3H-RAUWOLSCINE -13 34 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
4830 9902 46 3H-RAUWOLSCINE -13 34 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
92 9902 46 3H-RAUWOLSCINE -13 34 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
CHEMBL440294 9902 46 3H-RAUWOLSCINE -13 34 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
DB09286 9902 46 3H-RAUWOLSCINE -13 34 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
12575 8769 30 35S-GTPGammaS -53 17 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
54459 8769 30 35S-GTPGammaS -53 17 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
CHEMBL10316 8769 30 35S-GTPGammaS -53 17 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
44438147 100264 0 UNDEFINED -19 3 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 406 5 1 9 2.5 COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2 None
CHEMBL246228 100264 0 UNDEFINED -19 3 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 406 5 1 9 2.5 COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2 None
2803 7742 58 3H-RX821002 -1 19 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 3H-RX821002 -1 19 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 3H-RX821002 -1 19 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 3H-RX821002 -1 19 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 3H-RX821002 -1 19 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
162265 209053 22 3H-CLONIDINE -16 44 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 209053 22 3H-CLONIDINE -16 44 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 209053 22 3H-CLONIDINE -16 44 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
3652 53018 70 None -4 9 Human 8.4 pKi = 8.4 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
Drug Central 335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 None
CHEMBL1535 53018 70 None -4 9 Human 8.4 pKi = 8.4 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
Drug Central 335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 None
None 222737 0 3H-RAUWOLSCINE -112 19 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 421 9 1 6 4.3 COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4 None
2719 7704 74 None -10 11 Human 8.4 pKi = 8.4 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
Drug Central 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC None
5535 7704 74 None -10 11 Human 8.4 pKi = 8.4 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
Drug Central 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC None
607 7704 74 None -10 11 Human 8.4 pKi = 8.4 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
Drug Central 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC None
CHEMBL76 7704 74 None -10 11 Human 8.4 pKi = 8.4 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
Drug Central 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC None
DB00608 7704 74 None -10 11 Human 8.4 pKi = 8.4 Binding
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
Drug Central 319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC None
2216 7234 50 3H-RAUWOLSCINE -2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
229 7234 50 3H-RAUWOLSCINE -2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
7117 7234 50 3H-RAUWOLSCINE -2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
CHEMBL647 7234 50 3H-RAUWOLSCINE -2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
DB00964 7234 50 3H-RAUWOLSCINE -2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
219050 10146 25 3H-RX821002 -29 21 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
52 10146 25 3H-RX821002 -29 21 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
CHEMBL431367 10146 25 3H-RX821002 -29 21 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
138107169 222731 0 3H-MK912 -5 23 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
22831402 222731 0 3H-MK912 -5 23 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
12575 8769 30 3H-RAUWOLSCINE -3 17 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
54459 8769 30 3H-RAUWOLSCINE -3 17 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
CHEMBL10316 8769 30 3H-RAUWOLSCINE -3 17 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 None
2726 7706 68 3H-RAUWOLSCINE -8 72 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-RAUWOLSCINE -8 72 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-RAUWOLSCINE -8 72 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-RAUWOLSCINE -8 72 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-RAUWOLSCINE -8 72 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
55245 25352 81 None -3 3 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 429 2 1 3 5.4 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C None
CHEMBL1276308 25352 81 None -3 3 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 429 2 1 3 5.4 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C None
28417 46813 49 None -1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C None
CHEMBL1479 46813 49 None -1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C None
10297 33885 30 3H-CLONIDINE -1 43 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 None
CHEMBL136560 33885 30 3H-CLONIDINE -1 43 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 None
11079 9510 63 35S-GTPGammaS -3 5 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
3369 9510 63 35S-GTPGammaS -3 5 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
4436 9510 63 35S-GTPGammaS -3 5 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
5509 9510 63 35S-GTPGammaS -3 5 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
CHEMBL761 9510 63 35S-GTPGammaS -3 5 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
DB06711 9510 63 35S-GTPGammaS -3 5 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
2435 10362 83 3H-CLONIDINE -104 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
2435 10362 83 3H-RAUWOLSCINE -104 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-CLONIDINE -104 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-RAUWOLSCINE -104 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-CLONIDINE -104 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-RAUWOLSCINE -104 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-CLONIDINE -104 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-RAUWOLSCINE -104 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-CLONIDINE -104 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-RAUWOLSCINE -104 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
135 9310 43 3H-RAUWOLSCINE -13 56 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-RAUWOLSCINE -13 56 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-RAUWOLSCINE -13 56 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-RAUWOLSCINE -13 56 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-RAUWOLSCINE -13 56 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
164512323 222810 0 3H-RAUWOLSCINE -12 5 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 352 1 1 4 3.2 CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 None
6419959 222810 0 3H-RAUWOLSCINE -12 5 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 352 1 1 4 3.2 CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 None
1222 8445 49 3H-RAUWOLSCINE -30 32 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3396 8445 49 3H-RAUWOLSCINE -30 32 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
85 8445 49 3H-RAUWOLSCINE -30 32 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL46516 8445 49 3H-RAUWOLSCINE -30 32 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
DB04842 8445 49 3H-RAUWOLSCINE -30 32 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
2865 10915 73 3H-CLONIDINE -38 53 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
2865 10915 73 3H-RAUWOLSCINE -38 53 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-CLONIDINE -38 53 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-RAUWOLSCINE -38 53 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-CLONIDINE -38 53 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-RAUWOLSCINE -38 53 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-CLONIDINE -38 53 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-RAUWOLSCINE -38 53 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-CLONIDINE -38 53 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-RAUWOLSCINE -38 53 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
1353 8692 93 3H-CLONIDINE -85 85 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1353 8692 93 3H-RAUWOLSCINE -85 85 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-CLONIDINE -85 85 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-RAUWOLSCINE -85 85 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-CLONIDINE -85 85 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-RAUWOLSCINE -85 85 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-CLONIDINE -85 85 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-RAUWOLSCINE -85 85 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-CLONIDINE -85 85 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-RAUWOLSCINE -85 85 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
122295 16640 7 3H-RAUWOLSCINE -1 9 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 279 3 0 2 3.7 CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2 None
CHEMBL114166 16640 7 3H-RAUWOLSCINE -1 9 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 279 3 0 2 3.7 CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2 None
103 10925 61 3H-CLONIDINE -5 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 3H-CLONIDINE -5 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 3H-CLONIDINE -5 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 3H-CLONIDINE -5 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 3H-CLONIDINE -5 53 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
3823 56995 42 None -43 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
76973198 56995 42 None -43 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
CHEMBL157101 56995 42 None -43 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
2142 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
4920903 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
502 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
5775 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
CHEMBL597 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
DB00692 9870 58 3H-RAUWOLSCINE -1 37 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
None 222811 0 3H-RAUWOLSCINE -9 3 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 401 6 1 5 0.6 CS(=O)(=O)NCCN(C1CCN2CCC3=CC=CC=C3C2C1)S(=O)(=O)C None
176 7186 66 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
2157 7186 66 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
2566 7186 66 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
CHEMBL633 7186 66 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
DB01118 7186 66 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
448537 167029 89 None -33 25 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 None
CHEMBL411 167029 89 None -33 25 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 None
67409 222813 0 3H-RAUWOLSCINE 2 3 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 235 2 0 1 3.9 C=CCN1CC2=CC=CC=C2C3=CC=CC=C3C1 None
8966 222813 0 3H-RAUWOLSCINE 2 3 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 235 2 0 1 3.9 C=CCN1CC2=CC=CC=C2C3=CC=CC=C3C1 None
4209 9937 75 3H-RAUWOLSCINE -20 33 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 3H-RAUWOLSCINE -20 33 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 3H-RAUWOLSCINE -20 33 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 3H-RAUWOLSCINE -20 33 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 3H-RAUWOLSCINE -20 33 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 3H-RAUWOLSCINE -20 33 Rat 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
2812 11551 101 None -29 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
CHEMBL104 11551 101 None -29 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
2695 10613 81 None -69 6 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
5504 10613 81 None -69 6 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
7310 10613 81 None -69 6 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
CHEMBL770 10613 81 None -69 6 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
DB00797 10613 81 None -69 6 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 None
5282379 201763 69 None -2 3 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 300 5 1 1 5.6 CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1 None
CHEMBL547 201763 69 None -2 3 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 300 5 1 1 5.6 CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1 None
3198 212292 76 None -24 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1201049 212292 76 None -24 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL808 212292 76 None -24 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
4158 212120 21 None -1 21 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
CHEMBL1722 212120 21 None -1 21 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
CHEMBL796 212120 21 None -1 21 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
134 9292 24 None -93 67 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 None -93 67 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 None -93 67 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 None -93 67 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 None -93 67 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1210 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
1213 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
2725 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
33036 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
4411 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
616 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
6976 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
716121 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
CHEMBL1201353 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
CHEMBL1554789 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
CHEMBL505 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
DB01114 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
DB13679 7705 51 None -234 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
103 10925 61 3H-RAUWOLSCINE -5 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 3H-RAUWOLSCINE -5 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 3H-RAUWOLSCINE -5 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 3H-RAUWOLSCINE -5 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 3H-RAUWOLSCINE -5 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2247 7293 81 None -57 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
249 7293 81 None -57 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2603 7293 81 None -57 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
CHEMBL296419 7293 81 None -57 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
DB00637 7293 81 None -57 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2540 11173 111 None -1 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 None
CHEMBL1014 11173 111 None -1 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 None
2351 10059 64 None -15 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
2820 10059 64 None -15 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
5035 10059 64 None -15 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
CHEMBL81 10059 64 None -15 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
DB00481 10059 64 None -15 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
5353853 24758 47 None -17 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
9556529 24758 47 None -17 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1262 24758 47 None -17 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
1016 10519 78 None -18 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2561 10519 78 None -18 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2733526 10519 78 None -18 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5384 10519 78 None -18 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
CHEMBL83 10519 78 None -18 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
DB00675 10519 78 None -18 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5318 22348 49 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1200348 22348 49 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1221 22348 49 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
4189 213701 96 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 213701 96 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 213701 96 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
4098 39279 30 None -23 11 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 261 6 0 4 2.7 CN(C)CCN(Cc1cccs1)c1ccccn1 None
CHEMBL1255739 39279 30 None -23 11 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 261 6 0 4 2.7 CN(C)CCN(Cc1cccs1)c1ccccn1 None
CHEMBL1411979 39279 30 None -23 11 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 261 6 0 4 2.7 CN(C)CCN(Cc1cccs1)c1ccccn1 None
3117 214620 103 None -2 16 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC None
CHEMBL964 214620 103 None -2 16 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC None
3236 74383 43 None -1 2 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 259 5 0 2 3.6 CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1 None
CHEMBL1902981 74383 43 None -1 2 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 259 5 0 2 3.6 CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1 None
36811 8236 37 None -4 7 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O None
535 8236 37 None -4 7 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O None
937 8236 37 None -4 7 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O None
CHEMBL926 8236 37 None -4 7 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O None
DB00841 8236 37 None -4 7 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O None
441383 27105 57 None -4 17 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
CHEMBL1306 27105 57 None -4 17 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
5210 40112 48 None 123 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 None
CHEMBL1200765 40112 48 None 123 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 None
CHEMBL1419 40112 48 None 123 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 279 5 0 1 4.7 CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1 None
3658 10879 53 None -114 8 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C None
517 10879 53 None -114 8 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C None
5709 10879 53 None -114 8 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C None
CHEMBL312448 10879 53 None -114 8 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C None
DB06694 10879 53 None -114 8 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C None
1547484 7727 74 None -12 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
654 7727 74 None -12 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
9072 7727 74 None -12 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
CHEMBL43064 7727 74 None -12 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
DB00568 7727 74 None -12 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
11954259 222758 0 3H-CLONIDINE -165 43 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 443 5 0 5 3.5 CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C None
11954259 222758 0 3H-CLONIDINE -165 43 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 443 5 0 5 3.5 CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C None
104870 105656 47 35S-GTPGammaS -3 21 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
5374 105656 47 35S-GTPGammaS -3 21 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
CHEMBL279085 105656 47 35S-GTPGammaS -3 21 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
1830 9368 44 3H-CLONIDINE -10 28 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
207 9368 44 3H-CLONIDINE -10 28 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
23897 9368 44 3H-CLONIDINE -10 28 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
CHEMBL460 9368 44 3H-CLONIDINE -10 28 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
DB01618 9368 44 3H-CLONIDINE -10 28 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
115237 62359 119 3H-CLONIDINE -67 54 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 62359 119 3H-CLONIDINE -67 54 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
44438161 153919 0 UNDEFINED -63 3 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 543 10 1 7 5.0 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2 None
CHEMBL392771 153919 0 UNDEFINED -63 3 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 543 10 1 7 5.0 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2 None
None 222815 0 3H-RAUWOLSCINE 5 3 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 334 4 1 4 4.6 CN(C)CCCN1C2=C(C=C(C=C2)O)SC3=C1C=C(C=C3)Cl None
3075702 224111 0 3H-RAUWOLSCINE -1 37 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
12574 9383 88 None -12 6 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
Drug Central 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC None
4810 9383 88 None -12 6 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
Drug Central 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC None
CHEMBL19236 9383 88 None -12 6 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
Drug Central 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC None
DB09242 9383 88 None -12 6 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
Drug Central 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC None
124087 8171 114 None -28 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 None
7157 8171 114 None -28 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 None
814 8171 114 None -28 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 None
CHEMBL1172 8171 114 None -28 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 None
DB00967 8171 114 None -28 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 None
3151 8244 97 None -97 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 None
945 8244 97 None -97 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 None
965 8244 97 None -97 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 None
CHEMBL219916 8244 97 None -97 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 None
DB01184 8244 97 None -97 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 None
12488 8438 56 None -12 23 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F None
941361 8438 56 None -12 23 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F None
CHEMBL30008 8438 56 None -12 23 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F None
DB04841 8438 56 None -12 23 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F None
119584 9373 102 None -2 6 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl None
1848 9373 102 None -2 6 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl None
242 9373 102 None -2 6 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl None
CHEMBL60889 9373 102 None -2 6 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl None
DB11675 9373 102 None -2 6 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl None
4601 213526 35 None -3 17 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 269 6 0 2 3.7 Cc1ccccc1C(OCCN(C)C)c1ccccc1 None
CHEMBL1201023 213526 35 None -3 17 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 269 6 0 2 3.7 Cc1ccccc1C(OCCN(C)C)c1ccccc1 None
CHEMBL900 213526 35 None -3 17 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 269 6 0 2 3.7 Cc1ccccc1C(OCCN(C)C)c1ccccc1 None
237 211644 48 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 None
CHEMBL546257 211644 48 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 None
CHEMBL554190 211644 48 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 None
CHEMBL7568 211644 48 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 None
16362 9899 71 None -363 29 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
2172 9899 71 None -363 29 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
90 9899 71 None -363 29 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
CHEMBL1423 9899 71 None -363 29 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
DB01100 9899 71 None -363 29 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
5029 22317 92 None -13 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 359 8 1 5 3.0 COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C None
CHEMBL1219 22317 92 None -13 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 359 8 1 5 3.0 COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C None
9906855 224522 0 None -1 3 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 359 8 1 5 3.0 COCCCOC1=CC=NC(C[S@@](=O)C2=NC3=C(N2)C=CC=C3)=C1C None
2402 10143 62 None -3 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
5095 10143 62 None -3 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
7295 10143 62 None -3 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
CHEMBL589 10143 62 None -3 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
DB00268 10143 62 None -3 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
2337 10030 77 None -12 62 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 None -12 62 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 None -12 62 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 None -12 62 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 None -12 62 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
10836 21239 14 None 1 9 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 149 3 1 1 1.8 CN[C@@H](C)Cc1ccccc1 None
CHEMBL1201201 21239 14 None 1 9 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 149 3 1 1 1.8 CN[C@@H](C)Cc1ccccc1 None
1548955 95356 20 None -1 18 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 None
2800 95356 20 None -1 18 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 None
CHEMBL2355051 95356 20 None -1 18 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 None
1209 8439 75 None -12 32 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
203 8439 75 None -12 32 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
3386 8439 75 None -12 32 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
CHEMBL41 8439 75 None -12 32 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
DB00472 8439 75 None -12 32 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
2662 18156 131 None -1 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 None
CHEMBL118 18156 131 None -1 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 None
2342 7386 39 None -1 6 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC None
331 7386 39 None -1 6 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC None
7124 7386 39 None -1 6 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC None
CHEMBL1201250 7386 39 None -1 6 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC None
DB00767 7386 39 None -1 6 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC None
463 8187 22 None -57 13 Human 8.2 pKi = 8.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
6918097 8187 22 None -57 13 Human 8.2 pKi = 8.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
837 8187 22 None -57 13 Human 8.2 pKi = 8.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
CHEMBL2051956 8187 22 None -57 13 Human 8.2 pKi = 8.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
DB14068 8187 22 None -57 13 Human 8.2 pKi = 8.2 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
124 9755 47 None -977 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2032 9755 47 None -977 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
4636 9755 47 None -977 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
CHEMBL762 9755 47 None -977 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
DB00935 9755 47 None -977 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
119570 9933 96 None -29 39 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
2233 9933 96 None -29 39 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
953 9933 96 None -29 39 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
CHEMBL301265 9933 96 None -29 39 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
DB00413 9933 96 None -29 39 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
11057 182928 23 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
3468 182928 23 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
CHEMBL459265 182928 23 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
CHEMBL64894 182928 23 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
2406 107180 89 None -10 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O None
CHEMBL290106 107180 89 None -10 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O None
1830 9368 44 None -10 28 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
207 9368 44 None -10 28 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
23897 9368 44 None -10 28 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
CHEMBL460 9368 44 None -10 28 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
DB01618 9368 44 None -10 28 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
1443 8809 34 None -12 11 Human 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
33625 8809 34 None -12 11 Human 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
501 8809 34 None -12 11 Human 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
CHEMBL279516 8809 34 None -12 11 Human 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
DB08950 8809 34 None -12 11 Human 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
240 7731 43 None -11 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
2769 7731 43 None -11 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
44279790 7731 43 None -11 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
660 7731 43 None -11 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
CHEMBL1729 7731 43 None -11 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
CHEMBL560739 7731 43 None -11 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
DB00604 7731 43 None -11 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
3033538 8101 39 None -11 9 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 None
7155 8101 39 None -11 9 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 None
781 8101 39 None -11 9 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 None
CHEMBL1201216 8101 39 None -11 9 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 None
DB00298 8101 39 None -11 9 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 None
1353 8692 93 None -85 85 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 None -85 85 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 None -85 85 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 None -85 85 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 None -85 85 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
5511 12260 40 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 245 4 0 2 3.3 Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1 None
CHEMBL1076211 12260 40 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 245 4 0 2 3.3 Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1 None
2435 10362 83 None -104 48 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 None -104 48 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 None -104 48 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 None -104 48 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 None -104 48 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
11079 9510 63 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
3369 9510 63 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
4436 9510 63 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
5509 9510 63 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
CHEMBL761 9510 63 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
DB06711 9510 63 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 None
1028 7079 71 None -128 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
139148732 7079 71 None -128 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
479 7079 71 None -128 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
5816 7079 71 None -128 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
CHEMBL679 7079 71 None -128 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
DB00668 7079 71 None -128 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
33630 185736 99 None -9 28 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assay
Drug Central 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
CHEMBL47050 185736 99 None -9 28 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assay
Drug Central 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
3191 109635 97 None -9 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 None
CHEMBL305660 109635 97 None -9 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 None
100 10577 58 None -35 54 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 None -35 54 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 None -35 54 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 None -35 54 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 None -35 54 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
1530 8963 50 None -46 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 None
3827 8963 50 None -46 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 None
7206 8963 50 None -46 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 None
CHEMBL534 8963 50 None -46 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 None
DB00920 8963 50 None -46 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 None
2284 9956 33 None -3 29 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C None
4926 9956 33 None -3 29 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C None
7281 9956 33 None -3 29 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C None
CHEMBL564 9956 33 None -3 29 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C None
DB00420 9956 33 None -3 29 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C None
2335 18620 22 None -2 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
8478 18620 22 None -2 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
CHEMBL1182210 18620 22 None -2 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
CHEMBL221753 18620 22 None -2 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
2202 9906 96 None -1 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
4850 9906 96 None -1 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
49 9906 96 None -1 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
CHEMBL1371770 9906 96 None -1 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
DB12478 9906 96 None -1 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
162265 209053 22 None 5 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 209053 22 None 5 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 209053 22 None 5 44 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
191 7191 98 None -30 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
201 7191 98 None -30 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
2170 7191 98 None -30 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
CHEMBL1113 7191 98 None -30 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
DB00543 7191 98 None -30 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
3561 25849 39 None -1 11 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl None
CHEMBL1289 25849 39 None -1 11 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl None
66265 100788 15 None -1 19 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL248702 100788 15 None -1 19 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1 None
1890 9535 49 None -1 16 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl None
4449 9535 49 None -1 16 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl None
7247 9535 49 None -1 16 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl None
CHEMBL623 9535 49 None -1 16 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl None
DB01149 9535 49 None -1 16 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl None
150 9287 21 None -27 16 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO None
1764 9287 21 None -27 16 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO None
8226 9287 21 None -27 16 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO None
CHEMBL1201356 9287 21 None -27 16 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO None
DB00353 9287 21 None -27 16 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO None
104870 105656 47 None -3 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
5374 105656 47 None -3 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
CHEMBL279085 105656 47 None -3 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
1524 8962 96 None -27 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 None -27 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 None -27 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 None -27 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 None -27 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 None -27 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
6075 156887 42 None -6 16 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 None
CHEMBL395110 156887 42 None -6 16 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 None
213 10625 55 None -3 43 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
2717 10625 55 None -3 43 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
5533 10625 55 None -3 43 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
CHEMBL621 10625 55 None -3 43 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
DB00656 10625 55 None -3 43 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
26757 214757 31 None 1 2 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 187 4 0 1 2.2 C#CCN(C)[C@H](C)Cc1ccccc1 None
CHEMBL972 214757 31 None 1 2 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 187 4 0 1 2.2 C#CCN(C)[C@H](C)Cc1ccccc1 None
3294 8787 111 None -47 44 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 None -47 44 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 None -47 44 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 None -47 44 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 None -47 44 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
214 10632 58 None -39 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2740 10632 58 None -39 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5566 10632 58 None -39 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
66064 10632 58 None -39 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL422 10632 58 None -39 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00831 10632 58 None -39 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2142 9870 58 3H-RAUWOLSCINE -5 37 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
4920903 9870 58 3H-RAUWOLSCINE -5 37 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
502 9870 58 3H-RAUWOLSCINE -5 37 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
5775 9870 58 3H-RAUWOLSCINE -5 37 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
CHEMBL597 9870 58 3H-RAUWOLSCINE -5 37 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
DB00692 9870 58 3H-RAUWOLSCINE -5 37 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
26987 7736 33 None -281 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C None
6063 7736 33 None -281 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C None
671 7736 33 None -281 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C None
CHEMBL1626 7736 33 None -281 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C None
DB00283 7736 33 None -281 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C None
5472 212597 75 None 1 3 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 None
CHEMBL1717 212597 75 None 1 3 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 None
CHEMBL833 212597 75 None 1 3 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 None
5524 223243 0 None -1 4 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 215 1 2 3 1.9 C1CCC2=C(C1)C=CC=C2NC3=NCCN3 None
1042 8362 23 None -47 17 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C None
148 8362 23 None -47 17 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C None
443884 8362 23 None -47 17 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C None
CHEMBL119443 8362 23 None -47 17 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C None
DB01253 8362 23 None -47 17 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 325 3 3 3 1.5 OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C None
4011 89183 49 None -16 24 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 None
CHEMBL21731 89183 49 None -16 24 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 None
135398737 7745 93 3H-RAUWOLSCINE -9 90 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-RAUWOLSCINE -9 90 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-RAUWOLSCINE -9 90 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-RAUWOLSCINE -9 90 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-RAUWOLSCINE -9 90 Rat 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
3584 10549 64 None -21 14 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
5401 10549 64 None -21 14 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
7302 10549 64 None -21 14 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
CHEMBL611 10549 64 None -21 14 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
DB01162 10549 64 None -21 14 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
1613 9127 53 None -7 44 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 None -7 44 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 None -7 44 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 None -7 44 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 None -7 44 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
209 9831 97 None -38 23 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
2113 9831 97 None -38 23 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4748 9831 97 None -38 23 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL567 9831 97 None -38 23 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00850 9831 97 None -38 23 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
242 7258 124 None -64 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 None -64 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 None -64 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 None -64 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 None -64 51 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
119570 9933 96 3H-RX821002 -29 39 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
2233 9933 96 3H-RX821002 -29 39 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
953 9933 96 3H-RX821002 -29 39 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
CHEMBL301265 9933 96 3H-RX821002 -29 39 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
DB00413 9933 96 3H-RX821002 -29 39 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
1028 7079 71 35S-GTPGammaS -128 30 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
139148732 7079 71 35S-GTPGammaS -128 30 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
479 7079 71 35S-GTPGammaS -128 30 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
5816 7079 71 35S-GTPGammaS -128 30 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
CHEMBL679 7079 71 35S-GTPGammaS -128 30 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
DB00668 7079 71 35S-GTPGammaS -128 30 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
25137849 222958 0 3H-CLONIDINE -1 40 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
71290 222958 0 3H-CLONIDINE -1 40 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
121850 7513 0 3H-MK912 -131 3 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 215 2 1 3 1.6 CC1N(CC2=NCCN2)Cc2c1cccc2 None
525 7513 0 3H-MK912 -131 3 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 215 2 1 3 1.6 CC1N(CC2=NCCN2)Cc2c1cccc2 None
CHEMBL216097 7513 0 3H-MK912 -131 3 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 215 2 1 3 1.6 CC1N(CC2=NCCN2)Cc2c1cccc2 None
25058166 222739 0 3H-RX821002 -33 26 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 267 0 2 3 2.9 CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O None
6852389 222739 0 3H-RX821002 -33 26 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 267 0 2 3 2.9 CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O None
None 223019 0 3H-RX821002 -47 2 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 457 7 1 3 4.9 CCC(=O)NC1=C(C=C(C=C1C)C(=O)N2CCC(CC2)N(C)CCC3=CC=CC=C3)C.Cl None
133621 8793 0 35S-GTPGammaS -1 5 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 244 3 0 4 2.3 CCn1ccnc1CC1COc2c(O1)cccc2 None
3470 8793 0 35S-GTPGammaS -1 5 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 244 3 0 4 2.3 CCn1ccnc1CC1COc2c(O1)cccc2 None
CHEMBL347695 8793 0 35S-GTPGammaS -1 5 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 244 3 0 4 2.3 CCn1ccnc1CC1COc2c(O1)cccc2 None
119570 9933 96 3H-CLONIDINE -29 39 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
2233 9933 96 3H-CLONIDINE -29 39 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
953 9933 96 3H-CLONIDINE -29 39 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
CHEMBL301265 9933 96 3H-CLONIDINE -29 39 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
DB00413 9933 96 3H-CLONIDINE -29 39 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
6917970 10463 61 3H-CLONIDINE -1584 33 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
8370 10463 61 3H-CLONIDINE -1584 33 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
CHEMBL487387 10463 61 3H-CLONIDINE -1584 33 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
2803 7742 58 35S-GTPGammaS -1 19 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 35S-GTPGammaS -1 19 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 35S-GTPGammaS -1 19 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 35S-GTPGammaS -1 19 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 35S-GTPGammaS -1 19 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
3168 16034 92 None -39 22 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 None
CHEMBL1108 16034 92 None -39 22 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 None
1971 9641 38 None -3 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 None
2404 9641 38 None -3 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 None
4543 9641 38 None -3 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 None
CHEMBL445 9641 38 None -3 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 None
DB00540 9641 38 None -3 30 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 None
68617 212306 62 None -3 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 None
CHEMBL1709 212306 62 None -3 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 None
CHEMBL809 212306 62 None -3 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 None
1212 8443 50 None -38 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 None -38 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 None -38 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 None -38 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 None -38 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
135398745 9688 112 None -37 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 None -37 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 None -37 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 None -37 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
3389 224490 0 None -1 26 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 549 12 0 6 6.8 CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 None
37 7565 60 None -9 17 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
460 7565 60 None -9 17 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
54746 7565 60 None -9 17 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
CHEMBL1201087 7565 60 None -9 17 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
DB00248 7565 60 None -9 17 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
1960 9632 67 None -4 26 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
439260 9632 67 None -4 26 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
505 9632 67 None -4 26 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
CHEMBL1437 9632 67 None -4 26 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
DB00368 9632 67 None -4 26 Rat 8.2 pKi = 8.2 Binding
Binding affinity for rat Alpha-2B adrenergic receptorBinding affinity for rat Alpha-2B adrenergic receptor
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
3952 8669 38 None -18 12 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
5353646 8669 38 None -18 12 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
5443 8669 38 None -18 12 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
5702063 8669 38 None -18 12 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
CHEMBL1331786 8669 38 None -18 12 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
CHEMBL420 8669 38 None -18 12 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
1593 9119 66 None -6 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
Drug Central 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl None
30668 9119 66 None -6 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
Drug Central 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl None
9868 9119 66 None -6 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
Drug Central 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl None
CHEMBL17860 9119 66 None -6 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
Drug Central 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl None
DB04948 9119 66 None -6 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells
Drug Central 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl None
228 7233 28 None -3 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
33 7233 28 None -3 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
6005 7233 28 None -3 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
CHEMBL53 7233 28 None -3 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
DB00714 7233 28 None -3 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
2803 7742 58 3H-RAUWOLSCINE -1 19 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 3H-RAUWOLSCINE -1 19 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 3H-RAUWOLSCINE -1 19 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 3H-RAUWOLSCINE -1 19 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 3H-RAUWOLSCINE -1 19 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
2435 7509 100 None -3 12 Rat 8.1 pKi = 8.1 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
395 7509 100 None -3 12 Rat 8.1 pKi = 8.1 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
520 7509 100 None -3 12 Rat 8.1 pKi = 8.1 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
5386 7509 100 None -3 12 Rat 8.1 pKi = 8.1 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
CHEMBL844 7509 100 None -3 12 Rat 8.1 pKi = 8.1 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
DB00484 7509 100 None -3 12 Rat 8.1 pKi = 8.1 Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
212 10578 47 None -6 25 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
2639 10578 47 None -6 25 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
941651 10578 47 None -6 25 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
CHEMBL1201 10578 47 None -6 25 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
DB01623 10578 47 None -6 25 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
1222 8445 49 None -30 32 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3396 8445 49 None -30 32 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
85 8445 49 None -30 32 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL46516 8445 49 None -30 32 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
DB04842 8445 49 None -30 32 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
2865 10915 73 None -38 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 None -38 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 None -38 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 None -38 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 None -38 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
2398 7741 62 None -2 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
2801 7741 62 None -2 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
701 7741 62 None -2 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
CHEMBL415 7741 62 None -2 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
DB01242 7741 62 None -2 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
2585 7590 103 None -29 22 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O None
522 7590 103 None -29 22 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O None
551 7590 103 None -29 22 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O None
CHEMBL723 7590 103 None -29 22 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O None
DB01136 7590 103 None -29 22 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O None
68712 107114 60 None 1 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
Drug Central 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 None
CHEMBL289480 107114 60 None 1 5 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
Drug Central 180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1 None
135398737 7745 93 None -9 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 None -9 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 None -9 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 None -9 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 None -9 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
2181 9902 46 None -13 34 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
4830 9902 46 None -13 34 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
92 9902 46 None -13 34 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
CHEMBL440294 9902 46 None -13 34 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
DB09286 9902 46 None -13 34 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
2803 7742 58 None -1 19 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 None -1 19 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 None -1 19 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 None -1 19 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 None -1 19 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
31101 7516 40 None -33 35 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 None -33 35 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 None -33 35 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 None -33 35 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 None -33 35 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
2105 9828 37 None -8 32 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 None -8 32 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 None -8 32 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 None -8 32 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 None -8 32 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
1201549 7384 24 None -13 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
333 7384 24 None -13 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
7601 7384 24 None -13 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
CHEMBL1201203 7384 24 None -13 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
CHEMBL438151 7384 24 None -13 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
DB00245 7384 24 None -13 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
135 9310 43 None -8 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 None -8 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 None -8 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 None -8 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 None -8 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
2726 7706 68 None -8 72 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 None -8 72 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 None -8 72 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 None -8 72 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 None -8 72 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
2286 9957 51 None -4 30 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C None
4927 9957 51 None -4 30 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C None
7282 9957 51 None -4 30 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C None
CHEMBL643 9957 51 None -4 30 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C None
DB01069 9957 51 None -4 30 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C None
115237 62359 119 None -67 54 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 62359 119 None -67 54 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
277 8083 62 None -13 50 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 None -13 50 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 None -13 50 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 None -13 50 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 None -13 50 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
11978813 7508 79 None -9 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
5014 7508 79 None -9 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
7672 7508 79 None -9 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
CHEMBL2105760 7508 79 None -9 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
DB09128 7508 79 None -9 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
2389 10104 118 None -104 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 None -104 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 None -104 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 None -104 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 None -104 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
4209 9937 75 None -131 33 Human 8.1 pKi = 8.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 None -131 33 Human 8.1 pKi = 8.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 None -131 33 Human 8.1 pKi = 8.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 None -131 33 Human 8.1 pKi = 8.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 None -131 33 Human 8.1 pKi = 8.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 None -131 33 Human 8.1 pKi = 8.1 Binding
Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
None 222737 0 3H-RAUWOLSCINE -52 19 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 421 9 1 6 4.3 COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4 None
134551 7146 27 None -7 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C None
271 7146 27 None -7 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C None
885 7146 27 None -7 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C None
CHEMBL1403281 7146 27 None -7 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C None
5284550 48495 15 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 295 3 0 2 4.7 CN(C)CC/C=C1\c2ccccc2CSc2ccccc21 None
CHEMBL1492500 48495 15 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 295 3 0 2 4.7 CN(C)CC/C=C1\c2ccccc2CSc2ccccc21 None
2216 7234 50 None -2 6 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
229 7234 50 None -2 6 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
7117 7234 50 None -2 6 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
CHEMBL647 7234 50 None -2 6 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
DB00964 7234 50 None -2 6 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
124 9755 47 3H-RAUWOLSCINE -213 32 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2032 9755 47 3H-RAUWOLSCINE -213 32 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
4636 9755 47 3H-RAUWOLSCINE -213 32 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
CHEMBL762 9755 47 3H-RAUWOLSCINE -213 32 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
DB00935 9755 47 3H-RAUWOLSCINE -213 32 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
None 223120 0 3H-RX821002 -95 19 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 451 8 2 4 3.2 CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C None
10836 21239 14 3H-CLONIDINE 1 9 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 149 3 1 1 1.8 CN[C@@H](C)Cc1ccccc1 None
CHEMBL1201201 21239 14 3H-CLONIDINE 1 9 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 149 3 1 1 1.8 CN[C@@H](C)Cc1ccccc1 None
2337 10030 77 3H-CLONIDINE -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-CLONIDINE -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-CLONIDINE -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-CLONIDINE -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-CLONIDINE -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2337 10030 77 125I-Clonidine -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2337 10030 77 3H-CLONIDINE -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 125I-Clonidine -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-CLONIDINE -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 125I-Clonidine -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-CLONIDINE -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 125I-Clonidine -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-CLONIDINE -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 125I-Clonidine -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-CLONIDINE -12 62 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
16725934 154201 0 UNDEFINED -38 3 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 429 6 0 5 5.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2 None
CHEMBL392992 154201 0 UNDEFINED -38 3 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 429 6 0 5 5.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2 None
124 9755 47 3H-RAUWOLSCINE -977 32 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2032 9755 47 3H-RAUWOLSCINE -977 32 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
4636 9755 47 3H-RAUWOLSCINE -977 32 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
CHEMBL762 9755 47 3H-RAUWOLSCINE -977 32 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
DB00935 9755 47 3H-RAUWOLSCINE -977 32 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2402 10143 62 3H-RX821002 -3 24 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
5095 10143 62 3H-RX821002 -3 24 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
7295 10143 62 3H-RX821002 -3 24 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
CHEMBL589 10143 62 3H-RX821002 -3 24 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
DB00268 10143 62 3H-RX821002 -3 24 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
2683 10606 60 3H-RAUWOLSCINE -1 4 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 None
5487 10606 60 3H-RAUWOLSCINE -1 4 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 None
7308 10606 60 3H-RAUWOLSCINE -1 4 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 None
CHEMBL1079 10606 60 3H-RAUWOLSCINE -1 4 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 None
DB00697 10606 60 3H-RAUWOLSCINE -1 4 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 None
138107169 222731 0 3H-RAUWOLSCINE -5 23 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
22831402 222731 0 3H-RAUWOLSCINE -5 23 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
None 222737 0 3H-MK912 -112 19 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 421 9 1 6 4.3 COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4 None
2803 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 None -1 19 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
3584 10549 64 None -3 14 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
5401 10549 64 None -3 14 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
7302 10549 64 None -3 14 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
CHEMBL611 10549 64 None -3 14 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
DB01162 10549 64 None -3 14 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
2142 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
4920903 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
502 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
5775 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
CHEMBL597 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
DB00692 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-2B adrenergic receptor from human clones.Binding affinity against Alpha-2B adrenergic receptor from human clones.
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
133 9274 52 None -14 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 None -14 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 None -14 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 None -14 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 None -14 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
129211 10521 78 None -102 16 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
2562 10521 78 None -102 16 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
488 10521 78 None -102 16 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
CHEMBL836 10521 78 None -102 16 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
DB00706 10521 78 None -102 16 Rat 8.1 pKi = 8.1 Binding
Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
103 10925 61 None -5 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 None -5 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 None -5 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 None -5 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 None -5 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2216 7234 50 None -1 6 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
Drug Central 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
229 7234 50 None -1 6 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
Drug Central 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
7117 7234 50 None -1 6 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
Drug Central 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
CHEMBL647 7234 50 None -1 6 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
Drug Central 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
DB00964 7234 50 None -1 6 Rat 8.1 pKi = 8.1 Binding
Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells
Drug Central 244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1 None
2274 9947 58 None -3 31 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4917 9947 58 None -3 31 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
7279 9947 58 None -3 31 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL728 9947 58 None -3 31 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00433 9947 58 None -3 31 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
107715 207724 22 None -13 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O None
CHEMBL1255837 207724 22 None -13 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O None
CHEMBL601773 207724 22 None -13 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O None
2136 9869 30 None -3 6 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 None
4768 9869 30 None -3 6 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 None
7268 9869 30 None -3 6 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 None
CHEMBL753 9869 30 None -3 6 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 None
DB00925 9869 30 None -3 6 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 None
2389 10104 118 3H-RAUWOLSCINE -104 66 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-RAUWOLSCINE -104 66 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-RAUWOLSCINE -104 66 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-RAUWOLSCINE -104 66 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-RAUWOLSCINE -104 66 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
102 10899 48 None -10 49 Human 8.1 pKi = 8.1 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 None -10 49 Human 8.1 pKi = 8.1 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 None -10 49 Human 8.1 pKi = 8.1 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 None -10 49 Human 8.1 pKi = 8.1 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 None -10 49 Human 8.1 pKi = 8.1 Binding
Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
102 10899 48 None -10 49 Rat 8.1 pKi = 8.1 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 None -10 49 Rat 8.1 pKi = 8.1 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 None -10 49 Rat 8.1 pKi = 8.1 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 None -10 49 Rat 8.1 pKi = 8.1 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 None -10 49 Rat 8.1 pKi = 8.1 Binding
Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptorInhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
None 222737 0 3H-RAUWOLSCINE -52 19 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 421 9 1 6 4.3 COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4 None
46780481 114308 20 None -20 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 114308 20 None -20 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 114308 20 None -20 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 114308 20 None -20 53 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
10531 8202 21 None -10 24 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
121 8202 21 None -10 24 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
888 8202 21 None -10 24 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
CHEMBL1732 8202 21 None -10 24 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
DB00320 8202 21 None -10 24 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
11954224 222732 0 None -398 59 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
44438152 100383 0 UNDEFINED -42 3 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 459 7 0 6 5.7 COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1 None
CHEMBL246639 100383 0 UNDEFINED -42 3 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 459 7 0 6 5.7 COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1 None
104870 105656 47 3H-RX821002 -3 21 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
5374 105656 47 3H-RX821002 -3 21 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
CHEMBL279085 105656 47 3H-RX821002 -3 21 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
1212 8443 50 3H-CLONIDINE -38 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 3H-CLONIDINE -38 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 3H-CLONIDINE -38 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 3H-CLONIDINE -38 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 3H-CLONIDINE -38 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
135398745 9688 112 3H-CLONIDINE -37 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-CLONIDINE -37 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-CLONIDINE -37 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-CLONIDINE -37 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
1212 8443 50 3H-CLONIDINE -38 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 3H-CLONIDINE -38 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 3H-CLONIDINE -38 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 3H-CLONIDINE -38 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 3H-CLONIDINE -38 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
135398745 9688 112 3H-CLONIDINE -37 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-CLONIDINE -37 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-CLONIDINE -37 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-CLONIDINE -37 65 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
16362 9899 71 3H-CLONIDINE -363 29 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
2172 9899 71 3H-CLONIDINE -363 29 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
90 9899 71 3H-CLONIDINE -363 29 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
CHEMBL1423 9899 71 3H-CLONIDINE -363 29 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
DB01100 9899 71 3H-CLONIDINE -363 29 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
135398737 7745 93 3H-RAUWOLSCINE -9 90 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-RAUWOLSCINE -9 90 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-RAUWOLSCINE -9 90 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-RAUWOLSCINE -9 90 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-RAUWOLSCINE -9 90 Rat 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
44438167 155749 0 UNDEFINED -1071 3 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 505 7 1 7 3.8 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2 None
CHEMBL394218 155749 0 UNDEFINED -1071 3 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 505 7 1 7 3.8 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2 None
11954224 222732 0 3H-CLONIDINE -398 59 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
None 223018 0 3H-CLONIDINE -89125 29 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 316 7 3 3 3.0 CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O None
4209 9937 75 35S-GTPGammaS -131 33 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 35S-GTPGammaS -131 33 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 35S-GTPGammaS -131 33 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 35S-GTPGammaS -131 33 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 35S-GTPGammaS -131 33 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 35S-GTPGammaS -131 33 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
6761 74574 19 None -1 18 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 None
CHEMBL1909072 74574 19 None -1 18 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 None
2601 10552 33 None -1 21 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
443951 10552 33 None -1 21 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
56 10552 33 None -1 21 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL73151 10552 33 None -1 21 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
DB13399 10552 33 None -1 21 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
115237 62359 119 3H-RAUWOLSCINE -67 54 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 62359 119 3H-RAUWOLSCINE -67 54 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
1588 9105 27 None -1 44 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 None -1 44 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 None -1 44 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 None -1 44 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 None -1 44 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
521 8186 69 None -12 7 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C None
5311068 8186 69 None -12 7 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C None
835 8186 69 None -12 7 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C None
CHEMBL778 8186 69 None -12 7 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C None
DB00633 8186 69 None -12 7 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C None
2337 10030 77 3H-RAUWOLSCINE -12 62 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-RAUWOLSCINE -12 62 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-RAUWOLSCINE -12 62 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-RAUWOLSCINE -12 62 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-RAUWOLSCINE -12 62 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
None 223104 0 3H-CLONIDINE -1 40 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 149 2 1 2 1.2 CC(C(=O)C1=CC=CC=C1)N None
11225732 100432 0 UNDEFINED -53 3 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 497 6 0 5 6.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2 None
CHEMBL246852 100432 0 UNDEFINED -53 3 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 497 6 0 5 6.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2 None
135409468 8816 69 3H-CLONIDINE -33 39 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
333 8816 69 3H-CLONIDINE -33 39 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
CHEMBL845 8816 69 3H-CLONIDINE -33 39 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
2435 7509 100 35S-GTPGammaS -36 12 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
395 7509 100 35S-GTPGammaS -36 12 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
520 7509 100 35S-GTPGammaS -36 12 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
5386 7509 100 35S-GTPGammaS -36 12 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
CHEMBL844 7509 100 35S-GTPGammaS -36 12 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
DB00484 7509 100 35S-GTPGammaS -36 12 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
1593 9119 66 None -6 4 Human 7.2 pKi = 7.2 Binding
Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.
Guide to Pharmacology 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 22341244
30668 9119 66 None -6 4 Human 7.2 pKi = 7.2 Binding
Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.
Guide to Pharmacology 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 22341244
9868 9119 66 None -6 4 Human 7.2 pKi = 7.2 Binding
Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.
Guide to Pharmacology 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 22341244
CHEMBL17860 9119 66 None -6 4 Human 7.2 pKi = 7.2 Binding
Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.
Guide to Pharmacology 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 22341244
DB04948 9119 66 None -6 4 Human 7.2 pKi = 7.2 Binding
Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.
Guide to Pharmacology 258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl 22341244
2695 10613 81 None -69 6 Human 5.5 pKi = 5.5 Binding
Inhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S binding
Guide to Pharmacology 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 9605427
5504 10613 81 None -69 6 Human 5.5 pKi = 5.5 Binding
Inhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S binding
Guide to Pharmacology 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 9605427
7310 10613 81 None -69 6 Human 5.5 pKi = 5.5 Binding
Inhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S binding
Guide to Pharmacology 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 9605427
CHEMBL770 10613 81 None -69 6 Human 5.5 pKi = 5.5 Binding
Inhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S binding
Guide to Pharmacology 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 9605427
DB00797 10613 81 None -69 6 Human 5.5 pKi = 5.5 Binding
Inhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S binding
Guide to Pharmacology 160 2 1 2 1.2 c1ccc(cc1)CC1=NCCN1 9605427
2136 9869 30 None -3 6 Human 6.4 pKi = 6.4 Binding
Two site bindingTwo site binding
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 35224877
4768 9869 30 None -3 6 Human 6.4 pKi = 6.4 Binding
Two site bindingTwo site binding
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 35224877
7268 9869 30 None -3 6 Human 6.4 pKi = 6.4 Binding
Two site bindingTwo site binding
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 35224877
CHEMBL753 9869 30 None -3 6 Human 6.4 pKi = 6.4 Binding
Two site bindingTwo site binding
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 35224877
DB00925 9869 30 None -3 6 Human 6.4 pKi = 6.4 Binding
Two site bindingTwo site binding
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 35224877
1028 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
1028 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 9605427
139148732 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
139148732 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 9605427
479 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
479 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 9605427
5816 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
5816 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 9605427
CHEMBL679 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
CHEMBL679 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 9605427
DB00668 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 36101495
DB00668 7079 71 None -128 30 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 9605427
12574 9383 88 None -3890 6 Human 4.6 pKi = 4.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
4810 9383 88 None -3890 6 Human 4.6 pKi = 4.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
CHEMBL19236 9383 88 None -3890 6 Human 4.6 pKi = 4.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
DB09242 9383 88 None -3890 6 Human 4.6 pKi = 4.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC 36101495
1960 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
1960 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 9605427
1960 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 9824686
439260 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
439260 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 9605427
439260 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 9824686
505 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
505 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 9605427
505 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 9824686
CHEMBL1437 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
CHEMBL1437 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 9605427
CHEMBL1437 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 9824686
DB00368 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 36101495
DB00368 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 9605427
DB00368 9632 67 None -69 26 Human 4.8 pKi = 4.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 9824686
3658 10879 53 None -114 8 Human 5.4 pKi = 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
517 10879 53 None -114 8 Human 5.4 pKi = 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
5709 10879 53 None -114 8 Human 5.4 pKi = 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
CHEMBL312448 10879 53 None -114 8 Human 5.4 pKi = 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
DB06694 10879 53 None -114 8 Human 5.4 pKi = 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 36101495
523 10878 93 None -1 5 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
523 10878 93 None -1 5 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 9605427
5707 10878 93 None -1 5 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
5707 10878 93 None -1 5 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 9605427
CHEMBL297362 10878 93 None -1 5 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
CHEMBL297362 10878 93 None -1 5 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 9605427
DB11477 10878 93 None -1 5 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 36101495
DB11477 10878 93 None -1 5 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 220 1 1 3 3.2 Cc1cccc(c1NC1=NCCCS1)C 9605427
124 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
124 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7996470
124 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 9605427
2032 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
2032 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7996470
2032 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 9605427
4636 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
4636 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7996470
4636 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 9605427
CHEMBL762 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
CHEMBL762 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7996470
CHEMBL762 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 9605427
DB00935 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 36101495
DB00935 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7996470
DB00935 9755 47 None -977 32 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 9605427
4508 9913 98 None -398 13 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O 9605427
4866774 9913 98 None -398 13 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O 9605427
509 9913 98 None -398 13 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O 9605427
838 9913 98 None -398 13 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O 9605427
CHEMBL1740 9913 98 None -398 13 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O 9605427
121850 7513 0 None -131 3 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 215 2 1 3 1.6 CC1N(CC2=NCCN2)Cc2c1cccc2 35224877
121850 7513 0 None -131 3 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 215 2 1 3 1.6 CC1N(CC2=NCCN2)Cc2c1cccc2 7996470
525 7513 0 None -131 3 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 215 2 1 3 1.6 CC1N(CC2=NCCN2)Cc2c1cccc2 35224877
525 7513 0 None -131 3 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 215 2 1 3 1.6 CC1N(CC2=NCCN2)Cc2c1cccc2 7996470
CHEMBL216097 7513 0 None -131 3 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 215 2 1 3 1.6 CC1N(CC2=NCCN2)Cc2c1cccc2 35224877
CHEMBL216097 7513 0 None -131 3 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 215 2 1 3 1.6 CC1N(CC2=NCCN2)Cc2c1cccc2 7996470
2683 10606 60 None -20 4 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
5487 10606 60 None -20 4 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
7308 10606 60 None -20 4 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
CHEMBL1079 10606 60 None -20 4 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
DB00697 10606 60 None -20 4 Human 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 253 1 2 6 1.7 Clc1ccc2c(c1NC1=NCCN1)nsn2 36101495
3952 8669 38 None -18 12 Human 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5353646 8669 38 None -18 12 Human 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5443 8669 38 None -18 12 Human 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
5702063 8669 38 None -18 12 Human 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
CHEMBL1331786 8669 38 None -18 12 Human 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
CHEMBL420 8669 38 None -18 12 Human 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 36101495
1343 8670 62 None -91 9 Human 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
1343 8670 62 None -91 9 Human 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 9605427
3519 8670 62 None -91 9 Human 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
3519 8670 62 None -91 9 Human 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 9605427
522 8670 62 None -91 9 Human 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
522 8670 62 None -91 9 Human 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 9605427
CHEMBL862 8670 62 None -91 9 Human 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
CHEMBL862 8670 62 None -91 9 Human 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 9605427
DB01018 8670 62 None -91 9 Human 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 36101495
DB01018 8670 62 None -91 9 Human 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N 9605427
1816 9318 102 None -851 18 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10636247
1816 9318 102 None -851 18 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 35224877
4205 9318 102 None -851 18 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10636247
4205 9318 102 None -851 18 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 35224877
7241 9318 102 None -851 18 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10636247
7241 9318 102 None -851 18 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 35224877
CHEMBL654 9318 102 None -851 18 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10636247
CHEMBL654 9318 102 None -851 18 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 35224877
DB00370 9318 102 None -851 18 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10636247
DB00370 9318 102 None -851 18 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 35224877
12575 8769 30 None -53 17 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 35224877
54459 8769 30 None -53 17 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 35224877
CHEMBL10316 8769 30 None -53 17 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 35224877
4209 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 1353247
4209 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 35224877
4209 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7908642
4209 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7996470
4893 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 1353247
4893 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 35224877
4893 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7908642
4893 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7996470
503 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 1353247
503 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 35224877
503 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7908642
503 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7996470
5385 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 1353247
5385 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 35224877
5385 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7908642
5385 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7996470
CHEMBL2 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 1353247
CHEMBL2 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 35224877
CHEMBL2 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7908642
CHEMBL2 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7996470
DB00457 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 1353247
DB00457 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 35224877
DB00457 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7908642
DB00457 9937 75 None -131 33 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7996470
2435 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
2435 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9605427
2435 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9760042
2435 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9824686
395 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
395 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9605427
395 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9760042
395 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9824686
520 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
520 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9605427
520 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9760042
520 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9824686
5386 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
5386 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9605427
5386 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9760042
5386 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9824686
CHEMBL844 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
CHEMBL844 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9605427
CHEMBL844 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9760042
CHEMBL844 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9824686
DB00484 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 36101495
DB00484 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9605427
DB00484 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9760042
DB00484 7509 100 None -36 12 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 9824686
31101 7516 40 None -33 35 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
31101 7516 40 None -33 35 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 35224877
35 7516 40 None -33 35 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
35 7516 40 None -33 35 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 35224877
403 7516 40 None -33 35 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
403 7516 40 None -33 35 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 35224877
CHEMBL493 7516 40 None -33 35 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
CHEMBL493 7516 40 None -33 35 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 35224877
DB01200 7516 40 None -33 35 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
DB01200 7516 40 None -33 35 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 35224877
133621 8793 0 None 1 5 Rat 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 3 0 4 2.3 CCn1ccnc1CC1COc2c(O1)cccc2 1970500
3470 8793 0 None 1 5 Rat 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 3 0 4 2.3 CCn1ccnc1CC1COc2c(O1)cccc2 1970500
CHEMBL347695 8793 0 None 1 5 Rat 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 3 0 4 2.3 CCn1ccnc1CC1COc2c(O1)cccc2 1970500
2726 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1353247
2726 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 35224877
2726 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 7908642
621 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1353247
621 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 35224877
621 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 7908642
83 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1353247
83 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 35224877
83 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 7908642
CHEMBL71 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1353247
CHEMBL71 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 35224877
CHEMBL71 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 7908642
DB00477 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1353247
DB00477 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 35224877
DB00477 7706 68 None -8 72 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 7908642
2142 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 1353247
2142 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 35224877
2142 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7908642
4920903 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 1353247
4920903 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 35224877
4920903 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7908642
502 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 1353247
502 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 35224877
502 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7908642
5775 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 1353247
5775 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 35224877
5775 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7908642
CHEMBL597 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 1353247
CHEMBL597 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 35224877
CHEMBL597 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7908642
DB00692 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 1353247
DB00692 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 35224877
DB00692 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7908642
499 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 1353247
499 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 35224877
499 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 7908642
499 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 7996470
5685 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 1353247
5685 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 35224877
5685 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 7908642
5685 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 7996470
CHEMBL25554 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 1353247
CHEMBL25554 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 35224877
CHEMBL25554 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 7908642
CHEMBL25554 10849 18 None -85 14 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 7996470
122211 7250 0 None -6 6 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C 1353247
122211 7250 0 None -6 6 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C 35224877
122211 7250 0 None -6 6 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C 7908642
122211 7250 0 None -6 6 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C 7996470
524 7250 0 None -6 6 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C 1353247
524 7250 0 None -6 6 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C 35224877
524 7250 0 None -6 6 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C 7908642
524 7250 0 None -6 6 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 5 0 5 3.6 COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C 7996470
2803 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
2803 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9605427
2803 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9760042
2803 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9824686
516 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
516 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9605427
516 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9760042
516 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9824686
704 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
704 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9605427
704 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9760042
704 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9824686
CHEMBL134 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
CHEMBL134 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9605427
CHEMBL134 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9760042
CHEMBL134 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9824686
DB00575 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 36101495
DB00575 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9605427
DB00575 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9760042
DB00575 7742 58 None -1 19 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 9824686
12576 7302 94 None -7 6 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 35224877
71310 7302 94 None -7 6 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 35224877
CHEMBL353972 7302 94 None -7 6 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 35224877
DB11481 7302 94 None -7 6 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 2 1 1 2.9 CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 35224877
108094 10196 27 None -6 4 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 35224877
108094 10196 27 None -6 4 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 7996470
526 10196 27 None -6 4 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 35224877
526 10196 27 None -6 4 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 7996470
528 10196 27 None -6 4 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 35224877
528 10196 27 None -6 4 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 7996470
CHEMBL10332 10196 27 None -6 4 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 35224877
CHEMBL10332 10196 27 None -6 4 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1 7996470
12577 9341 0 None -50 3 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 0 0 3 3.3 CN1CC[C@]2(CCN3CCC4=C([C@@H]3C2)OC5=CC=CC=C45)N(C1=O)C 35224877
189711 9341 0 None -50 3 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 0 0 3 3.3 CN1CC[C@]2(CCN3CCC4=C([C@@H]3C2)OC5=CC=CC=C45)N(C1=O)C 35224877
CHEMBL1257057 9341 0 None -50 3 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 0 0 3 3.3 CN1CC[C@]2(CCN3CCC4=C([C@@H]3C2)OC5=CC=CC=C45)N(C1=O)C 35224877
103 10925 61 None -5 53 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 8935801
2875 10925 61 None -5 53 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 8935801
5736 10925 61 None -5 53 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 8935801
CHEMBL285802 10925 61 None -5 53 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 8935801
DB09225 10925 61 None -5 53 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 8935801
102 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 1353247
102 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 35224877
102 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7908642
102 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7996470
3659 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 1353247
3659 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 35224877
3659 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7908642
3659 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7996470
8969 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 1353247
8969 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 35224877
8969 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7908642
8969 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7996470
CHEMBL15245 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 1353247
CHEMBL15245 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 35224877
CHEMBL15245 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7908642
CHEMBL15245 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7996470
DB01392 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 1353247
DB01392 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 35224877
DB01392 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7908642
DB01392 10899 48 None -10 49 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7996470
5268 10428 40 None -3 18 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 35224877
5268 10428 40 None -3 18 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 7996470
53 10428 40 None -3 18 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 35224877
53 10428 40 None -3 18 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 7996470
CHEMBL300555 10428 40 None -3 18 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 35224877
CHEMBL300555 10428 40 None -3 18 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 7996470
2136 9869 30 None -3 6 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 1834671
4768 9869 30 None -3 6 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 1834671
7268 9869 30 None -3 6 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 1834671
CHEMBL753 9869 30 None -3 6 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 1834671
DB00925 9869 30 None -3 6 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 1834671
521 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
521 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9227000
521 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9605427
521 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9760042
521 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9824686
5311068 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
5311068 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9227000
5311068 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9605427
5311068 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9760042
5311068 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9824686
835 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
835 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9227000
835 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9605427
835 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9760042
835 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9824686
CHEMBL778 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
CHEMBL778 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9227000
CHEMBL778 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9605427
CHEMBL778 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9760042
CHEMBL778 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9824686
DB00633 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 36101495
DB00633 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9227000
DB00633 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9605427
DB00633 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9760042
DB00633 8186 69 None -12 7 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 9824686
13128 10173 0 None -6 3 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 364 3 0 4 2.4 CCS(=O)(=O)N1CCC[C@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C=C(C=C4)OC 35224877
9908992 10173 0 None -6 3 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 364 3 0 4 2.4 CCS(=O)(=O)N1CCC[C@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C=C(C=C4)OC 35224877
CHEMBL4303564 10173 0 None -6 3 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 364 3 0 4 2.4 CCS(=O)(=O)N1CCC[C@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C=C(C=C4)OC 35224877
1588 9105 27 None -1 44 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
1588 9105 27 None -1 44 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 35224877
28864 9105 27 None -1 44 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
28864 9105 27 None -1 44 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 35224877
43 9105 27 None -1 44 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
43 9105 27 None -1 44 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 35224877
CHEMBL157138 9105 27 None -1 44 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
CHEMBL157138 9105 27 None -1 44 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 35224877
DB00589 9105 27 None -1 44 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
DB00589 9105 27 None -1 44 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 35224877
2601 10552 33 None -1 21 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
443951 10552 33 None -1 21 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
56 10552 33 None -1 21 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
CHEMBL73151 10552 33 None -1 21 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
DB13399 10552 33 None -1 21 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
162265 209053 22 None -16 44 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 209053 22 None -16 44 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 209053 22 None -16 44 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
1960 9632 67 None -69 26 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
439260 9632 67 None -69 26 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
505 9632 67 None -69 26 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
CHEMBL1437 9632 67 None -69 26 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
DB00368 9632 67 None -69 26 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
3337 213146 27 None -14 40 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 None -14 40 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 None -14 40 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 None -14 40 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 None -14 40 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
37 7565 60 None -9 17 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
460 7565 60 None -9 17 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
54746 7565 60 None -9 17 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
CHEMBL1201087 7565 60 None -9 17 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
DB00248 7565 60 None -9 17 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
228 7233 28 None -3 23 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
33 7233 28 None -3 23 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
6005 7233 28 None -3 23 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
CHEMBL53 7233 28 None -3 23 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
DB00714 7233 28 None -3 23 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
2105 9828 37 None -8 32 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 12388666
47811 9828 37 None -8 32 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 12388666
48 9828 37 None -8 32 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 12388666
CHEMBL531 9828 37 None -8 32 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 12388666
DB01186 9828 37 None -8 32 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 12388666
136 10065 32 None -5 16 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7996470
223 10065 32 None -5 16 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7996470
643606 10065 32 None -5 16 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7996470
CHEMBL10347 10065 32 None -5 16 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 7996470
219050 10146 25 None -29 21 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 12388666
52 10146 25 None -29 21 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 12388666
CHEMBL431367 10146 25 None -29 21 Human 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 12388666