Biased Signaling Atlas

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	10621021	210163	0	None	66	2	Human	10.0	pEC50	=	10	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980204e
	CHEMBL65367	210163	0	None	66	2	Human	10.0	pEC50	=	10	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980204e
	10621021	210163	0	None	66	2	Human	10.0	pEC50	=	10	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
	CHEMBL65367	210163	0	None	66	2	Human	10.0	pEC50	=	10	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
	10719687	209778	0	None	257	2	Human	9.7	pEC50	=	9.7	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	485	7	1	4	5.7	FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
	CHEMBL63167	209778	0	None	257	2	Human	9.7	pEC50	=	9.7	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	485	7	1	4	5.7	FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
	11798094	61493	0	None	12	2	Human	9.7	pEC50	=	9.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	457	8	2	6	3.5	CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
	CHEMBL161176	61493	0	None	12	2	Human	9.7	pEC50	=	9.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	457	8	2	6	3.5	CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
	44214559	63272	0	None	35	2	Human	9.7	pEC50	=	9.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	443	8	2	6	2.5	NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	CHEMBL163462	63272	0	None	35	2	Human	9.7	pEC50	=	9.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	443	8	2	6	2.5	NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	10621021	210163	0	None	66	2	Human	9.7	pEC50	=	9.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	CHEMBL65367	210163	0	None	66	2	Human	9.7	pEC50	=	9.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	10376578	127857	3	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	230	3	2	1	3.2	CNCCc1c[nH]c2ccc(C(C)(C)C)cc12	10.1021/jm9805945
	CHEMBL357034	127857	3	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	230	3	2	1	3.2	CNCCc1c[nH]c2ccc(C(C)(C)C)cc12	10.1021/jm9805945
	44373641	127017	0	None	354	2	Human	9.6	pEC50	=	9.6	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.24-0.55Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.24-0.55	ChEMBL	408	7	2	5	2.4	COc1cccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)c1	10.1016/0960-894X(95)00091-7
	CHEMBL352234	127017	0	None	354	2	Human	9.6	pEC50	=	9.6	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.24-0.55Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.24-0.55	ChEMBL	408	7	2	5	2.4	COc1cccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)c1	10.1016/0960-894X(95)00091-7
	9796492	36755	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	304	4	1	4	2.9	CN(C)CCn1ccc2ccc(C3(O)CCSCC3)cc21	10.1016/j.bmcl.2003.09.025
	CHEMBL138872	36755	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	304	4	1	4	2.9	CN(C)CCn1ccc2ccc(C3(O)CCSCC3)cc21	10.1016/j.bmcl.2003.09.025
	10502669	63335	0	None	70	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	2	5	4.1	CC(C)(NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
	CHEMBL164046	63335	0	None	70	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	2	5	4.1	CC(C)(NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
	10716915	61919	0	None	114	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	418	7	1	5	3.6	Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	CHEMBL161723	61919	0	None	114	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	418	7	1	5	3.6	Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	10574570	63006	0	None	91	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	428	8	1	5	4.1	CC(CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm980569z
	CHEMBL162722	63006	0	None	91	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	428	8	1	5	4.1	CC(CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm980569z
	10788768	63269	0	None	20	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	430	8	2	6	3.0	OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	CHEMBL163386	63269	0	None	20	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	430	8	2	6	3.0	OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	10644750	63286	0	None	51	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	401	7	1	6	2.9	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm980569z
	CHEMBL163573	63286	0	None	51	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	401	7	1	6	2.9	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm980569z
	10596566	63343	0	None	46	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	390	7	1	6	3.1	c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1	10.1021/jm980569z
	CHEMBL164111	63343	0	None	46	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	390	7	1	6	3.1	c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1	10.1021/jm980569z
	10834909	171699	0	None	72	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	401	7	1	6	2.9	c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
	CHEMBL422366	171699	0	None	72	2	Human	9.5	pEC50	=	9.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	401	7	1	6	2.9	c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
	9844873	107835	0	None	48	2	Human	9.4	pEC50	=	9.4	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
	CHEMBL294732	107835	0	None	48	2	Human	9.4	pEC50	=	9.4	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
	9881526	108025	1	None	3	2	Human	9.4	pEC50	=	9.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9805687
	9881526	108025	1	None	3	2	Human	9.4	pEC50	=	9.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm980569z
	CHEMBL296161	108025	1	None	3	2	Human	9.4	pEC50	=	9.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9805687
	CHEMBL296161	108025	1	None	3	2	Human	9.4	pEC50	=	9.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm980569z
	9999722	170961	0	None	112	2	Human	9.4	pEC50	=	9.4	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cellsCompound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cells	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1016/0960-894X(95)00091-7
	CHEMBL421064	170961	0	None	112	2	Human	9.4	pEC50	=	9.4	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cellsCompound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cells	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1016/0960-894X(95)00091-7
	9881526	108025	1	None	3	2	Human	9.4	pEC50	=	9.4	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9704558
	CHEMBL296161	108025	1	None	3	2	Human	9.4	pEC50	=	9.4	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9704558
	9844873	107835	0	None	48	2	Human	9.3	pEC50	=	9.3	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
	CHEMBL294732	107835	0	None	48	2	Human	9.3	pEC50	=	9.3	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
	10319498	212612	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	412	5	1	5	3.5	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
	CHEMBL83426	212612	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	412	5	1	5	3.5	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
	11797644	60197	0	None	22	4	Human	9.3	pEC50	=	9.3	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	446	9	3	4	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1	10.1021/jm9805687
	CHEMBL160070	60197	0	None	22	4	Human	9.3	pEC50	=	9.3	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	446	9	3	4	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1	10.1021/jm9805687
	10620429	63038	0	None	39	2	Human	9.3	pEC50	=	9.3	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	390	7	1	6	3.1	c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
	CHEMBL162805	63038	0	None	39	2	Human	9.3	pEC50	=	9.3	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	390	7	1	6	3.1	c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
	9909089	193747	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL490417	193747	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	18975369	107806	0	None	120	2	Human	9.2	pEC50	=	9.2	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980204e
	CHEMBL294547	107806	0	None	120	2	Human	9.2	pEC50	=	9.2	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980204e
	18975369	107806	0	None	120	2	Human	9.2	pEC50	=	9.2	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm981133m
	CHEMBL294547	107806	0	None	120	2	Human	9.2	pEC50	=	9.2	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm981133m
	10385855	21197	0	None	3	3	Human	9.2	pEC50	=	9.2	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
	CHEMBL120055	21197	0	None	3	3	Human	9.2	pEC50	=	9.2	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
	CHEMBL321818	21197	0	None	3	3	Human	9.2	pEC50	=	9.2	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
	10503731	17061	0	None	72	2	Human	9.2	pEC50	=	9.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	450	8	1	5	3.8	Fc1cc(F)cc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm9704560
	CHEMBL116153	17061	0	None	72	2	Human	9.2	pEC50	=	9.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	450	8	1	5	3.8	Fc1cc(F)cc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm9704560
	9952249	59446	0	None	-1	2	Human	9.2	pEC50	=	9.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	388	6	1	7	2.3	c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm980569z
	CHEMBL159396	59446	0	None	-1	2	Human	9.2	pEC50	=	9.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	388	6	1	7	2.3	c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm980569z
	10693140	59853	0	None	75	2	Human	9.2	pEC50	=	9.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	2	5	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
	CHEMBL159759	59853	0	None	75	2	Human	9.2	pEC50	=	9.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	2	5	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
	6426761	20729	1	None	87	2	Human	9.2	pEC50	=	9.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	450	8	1	5	3.8	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F	10.1021/jm980569z
	CHEMBL119668	20729	1	None	87	2	Human	9.2	pEC50	=	9.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	450	8	1	5	3.8	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F	10.1021/jm980569z
	10386282	170879	0	None	7	4	Human	9.1	pEC50	=	9.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1016/s0960-894x(99)00409-6
	CHEMBL420965	170879	0	None	7	4	Human	9.1	pEC50	=	9.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1016/s0960-894x(99)00409-6
	10386282	170879	0	None	7	4	Human	9.1	pEC50	=	9.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	10386282	170879	0	None	7	4	Human	9.1	pEC50	=	9.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm980569z
	CHEMBL420965	170879	0	None	7	4	Human	9.1	pEC50	=	9.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	CHEMBL420965	170879	0	None	7	4	Human	9.1	pEC50	=	9.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm980569z
	10719202	63331	0	None	114	2	Human	9.1	pEC50	=	9.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	471	8	1	6	3.1	CN(C)C(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	CHEMBL164035	63331	0	None	114	2	Human	9.1	pEC50	=	9.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	471	8	1	6	3.1	CN(C)C(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	10341917	174828	0	None	97	2	Human	9.1	pEC50	=	9.1	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	417	7	1	4	4.6	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1	10.1021/jm981133m
	CHEMBL432332	174828	0	None	97	2	Human	9.1	pEC50	=	9.1	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	417	7	1	4	4.6	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1	10.1021/jm981133m
	10765655	121223	0	None	30	2	Human	9.1	pEC50	=	9.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	442	9	1	5	4.5	CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704558
	CHEMBL333341	121223	0	None	30	2	Human	9.1	pEC50	=	9.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	442	9	1	5	4.5	CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704558
	10645471	17814	0	None	128	2	Human	9.1	pEC50	=	9.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	1	5	3.5	c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
	CHEMBL117633	17814	0	None	128	2	Human	9.1	pEC50	=	9.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	1	5	3.5	c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
	10386282	170879	0	None	7	4	Human	9.0	pEC50	=	9.0	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
	CHEMBL420965	170879	0	None	7	4	Human	9.0	pEC50	=	9.0	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
	24804775	26115	0	None	-31	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay	ChEMBL	412	4	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1290716	26115	0	None	-31	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay	ChEMBL	412	4	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	114	9034	14	None	70	6	Human	9.0	pEC50	=	9	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm981133m
	6426760	9034	14	None	70	6	Human	9.0	pEC50	=	9	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm981133m
	CHEMBL292779	9034	14	None	70	6	Human	9.0	pEC50	=	9	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm981133m
	114	9034	14	None	70	6	Human	9.0	pEC50	=	9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980569z
	6426760	9034	14	None	70	6	Human	9.0	pEC50	=	9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980569z
	CHEMBL292779	9034	14	None	70	6	Human	9.0	pEC50	=	9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980569z
	11795333	63045	0	None	29	2	Human	9.0	pEC50	=	9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	401	7	1	6	2.9	c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1	10.1021/jm980569z
	CHEMBL162858	63045	0	None	29	2	Human	9.0	pEC50	=	9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	401	7	1	6	2.9	c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1	10.1021/jm980569z
	16	9033	8	None	69	5	Human	9.0	pEC50	=	9.0	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
	9847194	9033	8	None	69	5	Human	9.0	pEC50	=	9.0	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
	CHEMBL313714	9033	8	None	69	5	Human	9.0	pEC50	=	9.0	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
	16	9033	8	None	69	5	Human	9.0	pEC50	=	9.0	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704558
	9847194	9033	8	None	69	5	Human	9.0	pEC50	=	9.0	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704558
	CHEMBL313714	9033	8	None	69	5	Human	9.0	pEC50	=	9.0	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704558
	10764869	126515	0	None	144	2	Human	9.0	pEC50	=	9.0	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	425	7	1	6	3.4	N#Cc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	CHEMBL347665	126515	0	None	144	2	Human	9.0	pEC50	=	9.0	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	425	7	1	6	3.4	N#Cc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	114	9034	14	None	70	6	Human	8.9	pEC50	=	8.9	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
	6426760	9034	14	None	70	6	Human	8.9	pEC50	=	8.9	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
	CHEMBL292779	9034	14	None	70	6	Human	8.9	pEC50	=	8.9	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
	114	9034	14	None	70	6	Human	8.9	pEC50	=	8.9	Functional	Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704560
	6426760	9034	14	None	70	6	Human	8.9	pEC50	=	8.9	Functional	Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704560
	CHEMBL292779	9034	14	None	70	6	Human	8.9	pEC50	=	8.9	Functional	Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704560
	10476740	212875	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	411	5	1	4	4.1	CN1[C@@H](Cc2c[nH]c3ccc(-n4ccnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
	CHEMBL85668	212875	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	411	5	1	4	4.1	CN1[C@@H](Cc2c[nH]c3ccc(-n4ccnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
	10741528	61885	0	None	75	2	Human	8.9	pEC50	=	8.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	434	7	1	5	4.2	Clc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	CHEMBL161696	61885	0	None	75	2	Human	8.9	pEC50	=	8.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	434	7	1	5	4.2	Clc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	5487088	212626	38	None	19	2	Rat	8.9	pEC50	=	8.9	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	351	5	2	5	3.9	CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
	CHEMBL83597	212626	38	None	19	2	Rat	8.9	pEC50	=	8.9	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	351	5	2	5	3.9	CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
	10427186	212699	0	None	57	2	Rat	8.9	pEC50	=	8.9	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	337	5	3	5	3.5	O=[N+]([O-])c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm00042a003
	CHEMBL84107	212699	0	None	57	2	Rat	8.9	pEC50	=	8.9	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	337	5	3	5	3.5	O=[N+]([O-])c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm00042a003
	11794750	126682	0	None	15	2	Human	8.9	pEC50	=	8.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	390	8	2	6	3.0	c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1	10.1021/jm9805687
	CHEMBL349185	126682	0	None	15	2	Human	8.9	pEC50	=	8.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	390	8	2	6	3.0	c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1	10.1021/jm9805687
	10526736	16994	0	None	112	2	Human	8.9	pEC50	=	8.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	432	8	1	5	3.7	Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	CHEMBL116031	16994	0	None	112	2	Human	8.9	pEC50	=	8.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	432	8	1	5	3.7	Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	11796806	109494	0	None	169	2	Human	8.8	pEC50	=	8.8	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
	CHEMBL304857	109494	0	None	169	2	Human	8.8	pEC50	=	8.8	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
	10764998	120266	0	None	26	2	Human	8.8	pEC50	=	8.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9704558
	CHEMBL331970	120266	0	None	26	2	Human	8.8	pEC50	=	8.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9704558
	10574762	16915	0	None	109	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	432	8	1	5	3.7	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
	CHEMBL115750	16915	0	None	109	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	432	8	1	5	3.7	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
	10526736	16994	0	None	112	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	432	8	1	5	3.7	Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
	CHEMBL116031	16994	0	None	112	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	432	8	1	5	3.7	Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
	10501944	17809	0	None	26	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	1	5	3.7	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
	CHEMBL117579	17809	0	None	26	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	1	5	3.7	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
	10574762	16915	0	None	109	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	432	8	1	5	3.7	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	CHEMBL115750	16915	0	None	109	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	432	8	1	5	3.7	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	1884	9512	58	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10.1021/jm9805945
	4440	9512	58	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10.1021/jm9805945
	45	9512	58	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10.1021/jm9805945
	CHEMBL1278	9512	58	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10.1021/jm9805945
	DB00952	9512	58	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10.1021/jm9805945
	11796806	109494	0	None	169	2	Human	8.8	pEC50	=	8.8	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
	CHEMBL304857	109494	0	None	169	2	Human	8.8	pEC50	=	8.8	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
	10600213	209888	0	None	575	2	Human	8.8	pEC50	=	8.8	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	464	8	1	5	4.2	CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm981133m
	CHEMBL64004	209888	0	None	575	2	Human	8.8	pEC50	=	8.8	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	464	8	1	5	4.2	CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm981133m
	10501944	17809	0	None	26	2	Human	8.8	pEC50	=	8.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	414	8	1	5	3.7	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9704558
	CHEMBL117579	17809	0	None	26	2	Human	8.8	pEC50	=	8.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	414	8	1	5	3.7	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9704558
	11796806	109494	0	None	169	2	Human	8.8	pEC50	=	8.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704558
	CHEMBL304857	109494	0	None	169	2	Human	8.8	pEC50	=	8.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704558
	10814273	121129	0	None	100	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm9704560
	CHEMBL333089	121129	0	None	100	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm9704560
	44323355	213366	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	480	9	3	6	3.6	OC[C@H](NC1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm980204e
	CHEMBL88893	213366	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	480	9	3	6	3.6	OC[C@H](NC1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm980204e
	10252256	59551	0	None	22	4	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	432	9	3	4	3.5	O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1	10.1021/jm9805687
	CHEMBL159483	59551	0	None	22	4	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	432	9	3	4	3.5	O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1	10.1021/jm9805687
	10645471	17814	0	None	128	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	414	8	1	5	3.5	c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	CHEMBL117633	17814	0	None	128	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	414	8	1	5	3.5	c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	10789399	126652	0	None	13	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	443	9	2	6	3.3	CNCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	CHEMBL348962	126652	0	None	13	2	Human	8.8	pEC50	=	8.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	443	9	2	6	3.3	CNCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	10646958	18179	0	None	70	2	Human	8.7	pEC50	=	8.7	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9704558
	CHEMBL118012	18179	0	None	70	2	Human	8.7	pEC50	=	8.7	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9704558
	10502763	126920	0	None	102	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	430	9	3	6	2.9	OC[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
	CHEMBL351303	126920	0	None	102	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	430	9	3	6	2.9	OC[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
	10838153	20873	0	None	154	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	CHEMBL119785	20873	0	None	154	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	10766570	210159	0	None	501	2	Human	8.7	pEC50	=	8.7	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	464	8	1	5	4.2	CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1	10.1021/jm981133m
	CHEMBL65321	210159	0	None	501	2	Human	8.7	pEC50	=	8.7	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	464	8	1	5	4.2	CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1	10.1021/jm981133m
	15521392	212761	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	444	6	1	5	3.7	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(CCc3cccc(F)c3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
	CHEMBL84712	212761	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	444	6	1	5	3.7	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(CCc3cccc(F)c3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
	6426761	20729	1	None	87	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	450	8	1	5	3.8	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F	10.1021/jm9704560
	CHEMBL119668	20729	1	None	87	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	450	8	1	5	3.8	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F	10.1021/jm9704560
	10838153	20873	0	None	154	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
	CHEMBL119785	20873	0	None	154	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
	10718668	126697	0	None	15	2	Human	8.0	pEC50	=	8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	457	9	3	6	3.4	CC(=O)Nc1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	CHEMBL349390	126697	0	None	15	2	Human	8.0	pEC50	=	8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	457	9	3	6	3.4	CC(=O)Nc1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	10614906	117282	0	None	2	2	Human	7.0	pEC50	=	7.0	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	310	4	1	5	1.5	CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	CHEMBL324931	117282	0	None	2	2	Human	7.0	pEC50	=	7.0	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	310	4	1	5	1.5	CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	10341917	174828	0	None	97	2	Human	8.0	pEC50	=	8.0	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	417	7	1	4	4.6	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1	10.1021/jm980204e
	CHEMBL432332	174828	0	None	97	2	Human	8.0	pEC50	=	8.0	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	417	7	1	4	4.6	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1	10.1021/jm980204e
	11796808	59827	0	None	63	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	428	9	1	5	3.8	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1	10.1021/jm9805687
	CHEMBL159733	59827	0	None	63	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	428	9	1	5	3.8	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1	10.1021/jm9805687
	11798502	63267	0	None	37	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	468	7	1	5	4.5	FC(F)(F)c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	CHEMBL163376	63267	0	None	37	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	468	7	1	5	4.5	FC(F)(F)c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	124	9755	47	None	-69	25	Human	6.9	pEC50	=	6.9	Functional	Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm970513p
	2032	9755	47	None	-69	25	Human	6.9	pEC50	=	6.9	Functional	Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm970513p
	4636	9755	47	None	-69	25	Human	6.9	pEC50	=	6.9	Functional	Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm970513p
	CHEMBL762	9755	47	None	-69	25	Human	6.9	pEC50	=	6.9	Functional	Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm970513p
	DB00935	9755	47	None	-69	25	Human	6.9	pEC50	=	6.9	Functional	Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm970513p
	9837525	109932	1	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	230	3	1	2	3.0	Cc1cc(C(C)C)cc(C)c1CC1=NCCN1	10.1021/jm970513p
	CHEMBL308042	109932	1	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	230	3	1	2	3.0	Cc1cc(C(C)C)cc(C)c1CC1=NCCN1	10.1021/jm970513p
	2543	10479	68	None	-2	14	Human	7.9	pEC50	=	7.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805687
	2543	10479	68	None	-2	14	Human	7.9	pEC50	=	7.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980569z
	5358	10479	68	None	-2	14	Human	7.9	pEC50	=	7.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805687
	5358	10479	68	None	-2	14	Human	7.9	pEC50	=	7.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980569z
	54	10479	68	None	-2	14	Human	7.9	pEC50	=	7.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805687
	54	10479	68	None	-2	14	Human	7.9	pEC50	=	7.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980569z
	CHEMBL128	10479	68	None	-2	14	Human	7.9	pEC50	=	7.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805687
	CHEMBL128	10479	68	None	-2	14	Human	7.9	pEC50	=	7.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980569z
	DB00669	10479	68	None	-2	14	Human	7.9	pEC50	=	7.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805687
	DB00669	10479	68	None	-2	14	Human	7.9	pEC50	=	7.9	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980569z
	9930155	170811	0	None	12	2	Human	7.8	pEC50	=	7.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
	CHEMBL420874	170811	0	None	12	2	Human	7.8	pEC50	=	7.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
	9930155	170811	0	None	12	2	Human	7.8	pEC50	=	7.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	CHEMBL420874	170811	0	None	12	2	Human	7.8	pEC50	=	7.8	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	3016908	211223	24	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	202	2	1	2	2.2	Cc1cc(C)c(CC2=NCCN2)c(C)c1	10.1021/jm970513p
	CHEMBL72178	211223	24	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	202	2	1	2	2.2	Cc1cc(C)c(CC2=NCCN2)c(C)c1	10.1021/jm970513p
	10837853	174937	0	None	309	2	Human	7.8	pEC50	=	7.8	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	464	8	1	5	4.3	CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm981133m
	CHEMBL433108	174937	0	None	309	2	Human	7.8	pEC50	=	7.8	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	464	8	1	5	4.3	CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm981133m
	2543	10479	68	None	-2	14	Human	7.8	pEC50	=	7.8	Functional	Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
	5358	10479	68	None	-2	14	Human	7.8	pEC50	=	7.8	Functional	Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
	54	10479	68	None	-2	14	Human	7.8	pEC50	=	7.8	Functional	Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
	CHEMBL128	10479	68	None	-2	14	Human	7.8	pEC50	=	7.8	Functional	Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
	DB00669	10479	68	None	-2	14	Human	7.8	pEC50	=	7.8	Functional	Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
	2543	10479	68	None	-2	14	Human	7.8	pEC50	=	7.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704558
	5358	10479	68	None	-2	14	Human	7.8	pEC50	=	7.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704558
	54	10479	68	None	-2	14	Human	7.8	pEC50	=	7.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704558
	CHEMBL128	10479	68	None	-2	14	Human	7.8	pEC50	=	7.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704558
	DB00669	10479	68	None	-2	14	Human	7.8	pEC50	=	7.8	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704558
	9816035	210912	1	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	230	2	1	2	2.8	Cc1cc(C(C)(C)C)ccc1CC1=NCCN1	10.1021/jm970513p
	CHEMBL70409	210912	1	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	230	2	1	2	2.8	Cc1cc(C(C)(C)C)ccc1CC1=NCCN1	10.1021/jm970513p
	9803620	169239	0	None	123	2	Human	7.8	pEC50	=	7.8	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
	CHEMBL416688	169239	0	None	123	2	Human	7.8	pEC50	=	7.8	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
	9803620	169239	0	None	123	2	Human	7.8	pEC50	=	7.8	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
	CHEMBL416688	169239	0	None	123	2	Human	7.8	pEC50	=	7.8	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
	10381677	113340	0	None	24	2	Rat	8.7	pEC50	=	8.7	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	325	6	2	5	3.3	CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
	CHEMBL314213	113340	0	None	24	2	Rat	8.7	pEC50	=	8.7	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	325	6	2	5	3.3	CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
	5492087	212789	4	None	95	2	Rat	8.7	pEC50	=	8.7	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	337	4	2	5	3.6	CN1CCC(c2c[nH]c3ccc(Nc4ncccc4[N+](=O)[O-])cc23)C1	10.1021/jm00042a003
	CHEMBL84942	212789	4	None	95	2	Rat	8.7	pEC50	=	8.7	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	337	4	2	5	3.6	CN1CCC(c2c[nH]c3ccc(Nc4ncccc4[N+](=O)[O-])cc23)C1	10.1021/jm00042a003
	10548444	63687	0	None	20	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	390	7	2	6	2.2	c1c[nH]c(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)n1	10.1021/jm980569z
	CHEMBL164413	63687	0	None	20	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	390	7	2	6	2.2	c1c[nH]c(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)n1	10.1021/jm980569z
	10739818	117920	0	None	39	2	Human	8.7	pEC50	=	8.7	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	401	8	1	5	3.8	c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
	CHEMBL326371	117920	0	None	39	2	Human	8.7	pEC50	=	8.7	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	401	8	1	5	3.8	c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
	10501945	61708	0	None	60	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	2	5	4.0	C[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
	CHEMBL161410	61708	0	None	60	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	2	5	4.0	C[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
	10739818	117920	0	None	39	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	401	8	1	5	3.8	c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	CHEMBL326371	117920	0	None	39	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	401	8	1	5	3.8	c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	10468938	17016	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9805687
	10468938	17016	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm980569z
	CHEMBL116092	17016	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9805687
	CHEMBL116092	17016	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm980569z
	10574671	127003	0	None	13	2	Human	8.6	pEC50	=	8.6	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	430	7	1	5	3.8	S=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1	10.1021/jm980569z
	CHEMBL352159	127003	0	None	13	2	Human	8.6	pEC50	=	8.6	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	430	7	1	5	3.8	S=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1	10.1021/jm980569z
	10551328	210500	0	None	97	2	Human	8.6	pEC50	=	8.6	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	445	8	1	4	5.7	CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm981133m
	CHEMBL67684	210500	0	None	97	2	Human	8.6	pEC50	=	8.6	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	445	8	1	4	5.7	CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm981133m
	10468938	17016	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9704558
	CHEMBL116092	17016	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9704558
	10468938	17016	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9704560
	CHEMBL116092	17016	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9704560
	10048222	60771	0	None	33	2	Human	8.6	pEC50	=	8.6	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 2.8-6.5Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 2.8-6.5	ChEMBL	428	6	2	4	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4cccc5ccccc45)CC3)cc12	10.1016/0960-894X(95)00091-7
	CHEMBL160581	60771	0	None	33	2	Human	8.6	pEC50	=	8.6	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 2.8-6.5Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 2.8-6.5	ChEMBL	428	6	2	4	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4cccc5ccccc45)CC3)cc12	10.1016/0960-894X(95)00091-7
	10572483	126665	0	None	9	2	Human	8.6	pEC50	=	8.6	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	390	8	2	6	3.0	c1coc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1	10.1021/jm9805687
	CHEMBL349041	126665	0	None	9	2	Human	8.6	pEC50	=	8.6	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	390	8	2	6	3.0	c1coc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1	10.1021/jm9805687
	15521391	212460	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	430	5	1	5	3.6	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccc(F)cc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
	CHEMBL82204	212460	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	430	5	1	5	3.6	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccc(F)cc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
	2393	10107	82	None	-2	9	Human	8.5	pEC50	=	8.5	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9805945
	5078	10107	82	None	-2	9	Human	8.5	pEC50	=	8.5	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9805945
	51	10107	82	None	-2	9	Human	8.5	pEC50	=	8.5	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9805945
	CHEMBL905	10107	82	None	-2	9	Human	8.5	pEC50	=	8.5	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9805945
	DB00953	10107	82	None	-2	9	Human	8.5	pEC50	=	8.5	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9805945
	10597902	59774	0	None	9	2	Human	8.5	pEC50	=	8.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	1	5	3.9	CN(Cc1ccccc1)C[C@@H]1CCCN1CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9805687
	CHEMBL159683	59774	0	None	9	2	Human	8.5	pEC50	=	8.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	1	5	3.9	CN(Cc1ccccc1)C[C@@H]1CCCN1CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9805687
	11796807	172322	0	None	109	2	Human	8.5	pEC50	=	8.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	428	9	2	5	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1)c1ccccc1	10.1021/jm9805687
	CHEMBL424154	172322	0	None	109	2	Human	8.5	pEC50	=	8.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	428	9	2	5	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1)c1ccccc1	10.1021/jm9805687
	10600063	126789	0	None	29	2	Human	8.5	pEC50	=	8.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	460	9	1	4	4.2	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4C)cc23)C1	10.1021/jm9805687
	CHEMBL350153	126789	0	None	29	2	Human	8.5	pEC50	=	8.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	460	9	1	4	4.2	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4C)cc23)C1	10.1021/jm9805687
	9867902	61993	0	None	20	4	Human	8.5	pEC50	=	8.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	440	10	3	4	2.9	CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1	10.1021/jm9805687
	CHEMBL161780	61993	0	None	20	4	Human	8.5	pEC50	=	8.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	440	10	3	4	2.9	CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1	10.1021/jm9805687
	10575553	209818	0	None	245	2	Human	8.4	pEC50	=	8.4	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
	CHEMBL63432	209818	0	None	245	2	Human	8.4	pEC50	=	8.4	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
	44214559	63272	0	None	35	2	Human	8.4	pEC50	=	8.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	443	8	2	6	2.5	NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	CHEMBL163462	63272	0	None	35	2	Human	8.4	pEC50	=	8.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	443	8	2	6	2.5	NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	2543	10479	68	None	-2	14	Human	7.5	pEC50	=	7.5	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
	5358	10479	68	None	-2	14	Human	7.5	pEC50	=	7.5	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
	54	10479	68	None	-2	14	Human	7.5	pEC50	=	7.5	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
	CHEMBL128	10479	68	None	-2	14	Human	7.5	pEC50	=	7.5	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
	DB00669	10479	68	None	-2	14	Human	7.5	pEC50	=	7.5	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
	10596387	175238	0	None	11	2	Human	7.5	pEC50	=	7.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	CHEMBL435060	175238	0	None	11	2	Human	7.5	pEC50	=	7.5	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	9930155	170811	0	None	12	2	Human	7.5	pEC50	=	7.5	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
	CHEMBL420874	170811	0	None	12	2	Human	7.5	pEC50	=	7.5	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
	10671315	209790	0	None	186	2	Human	7.5	pEC50	=	7.5	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	451	8	1	5	4.6	FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1	10.1021/jm981133m
	CHEMBL63258	209790	0	None	186	2	Human	7.5	pEC50	=	7.5	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	451	8	1	5	4.6	FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1	10.1021/jm981133m
	10695596	109570	0	None	69	2	Human	7.5	pEC50	=	7.5	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	468	8	1	5	3.9	Fc1cccc(CCN2CCN(CC(F)(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
	CHEMBL305301	109570	0	None	69	2	Human	7.5	pEC50	=	7.5	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	468	8	1	5	3.9	Fc1cccc(CCN2CCN(CC(F)(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
	3658	10879	53	None	-38	18	Human	6.4	pEC50	=	6.4	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1021/jm970513p
	517	10879	53	None	-38	18	Human	6.4	pEC50	=	6.4	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1021/jm970513p
	5709	10879	53	None	-38	18	Human	6.4	pEC50	=	6.4	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1021/jm970513p
	CHEMBL312448	10879	53	None	-38	18	Human	6.4	pEC50	=	6.4	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1021/jm970513p
	DB06694	10879	53	None	-38	18	Human	6.4	pEC50	=	6.4	Functional	Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1021/jm970513p
	10670211	126998	0	None	19	2	Human	8.4	pEC50	=	8.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	428	9	1	5	3.9	c1ccc(CCCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	CHEMBL352123	126998	0	None	19	2	Human	8.4	pEC50	=	8.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	428	9	1	5	3.9	c1ccc(CCCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	10811007	59919	0	None	19	2	Human	8.4	pEC50	=	8.4	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
	CHEMBL159819	59919	0	None	19	2	Human	8.4	pEC50	=	8.4	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
	10811007	59919	0	None	19	2	Human	8.4	pEC50	=	8.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	CHEMBL159819	59919	0	None	19	2	Human	8.4	pEC50	=	8.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	2543	10479	68	None	-2	14	Human	8.4	pEC50	=	8.4	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805945
	5358	10479	68	None	-2	14	Human	8.4	pEC50	=	8.4	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805945
	54	10479	68	None	-2	14	Human	8.4	pEC50	=	8.4	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805945
	CHEMBL128	10479	68	None	-2	14	Human	8.4	pEC50	=	8.4	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805945
	DB00669	10479	68	None	-2	14	Human	8.4	pEC50	=	8.4	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805945
	10575553	209818	0	None	245	2	Human	8.4	pEC50	=	8.4	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980204e
	CHEMBL63432	209818	0	None	245	2	Human	8.4	pEC50	=	8.4	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980204e
	10670879	126646	0	None	48	2	Human	8.4	pEC50	=	8.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	442	9	1	5	4.4	C[C@@H](c1ccccc1)N(C)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1	10.1021/jm9805687
	CHEMBL348864	126646	0	None	48	2	Human	8.4	pEC50	=	8.4	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	442	9	1	5	4.4	C[C@@H](c1ccccc1)N(C)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1	10.1021/jm9805687
	11796081	61511	0	None	66	2	Human	8.3	pEC50	=	8.3	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	9	2	5	3.5	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(Cn5cncn5)cc34)C2)cc1	10.1021/jm9805687
	CHEMBL161192	61511	0	None	66	2	Human	8.3	pEC50	=	8.3	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	9	2	5	3.5	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(Cn5cncn5)cc34)C2)cc1	10.1021/jm9805687
	9881324	35145	3	None	-1	4	Guinea pig	7.4	pEC50	=	7.4	Functional	Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.	ChEMBL	244	3	1	2	2.8	COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1021/jm00101a032
	CHEMBL137485	35145	3	None	-1	4	Guinea pig	7.4	pEC50	=	7.4	Functional	Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.	ChEMBL	244	3	1	2	2.8	COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1021/jm00101a032
	10503687	209856	0	None	50	2	Human	8.3	pEC50	=	8.3	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	449	8	1	4	5.3	Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
	CHEMBL63799	209856	0	None	50	2	Human	8.3	pEC50	=	8.3	Functional	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	449	8	1	4	5.3	Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
	24762221	26091	0	None	39	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay	ChEMBL	414	4	1	4	4.1	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1290596	26091	0	None	39	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay	ChEMBL	414	4	1	4	4.1	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	10503687	209856	0	None	50	2	Human	8.3	pEC50	=	8.3	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	449	8	1	4	5.3	Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980204e
	CHEMBL63799	209856	0	None	50	2	Human	8.3	pEC50	=	8.3	Functional	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	ChEMBL	449	8	1	4	5.3	Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980204e
	5	6927	72	None	-12	27	Guinea pig	8.3	pEC50	=	8.3	Functional	Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
	5202	6927	72	None	-12	27	Guinea pig	8.3	pEC50	=	8.3	Functional	Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
	CHEMBL39	6927	72	None	-12	27	Guinea pig	8.3	pEC50	=	8.3	Functional	Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
	DB08839	6927	72	None	-12	27	Guinea pig	8.3	pEC50	=	8.3	Functional	Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
	5	6927	72	None	-7	27	Rat	8.3	pEC50	=	8.3	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
	5202	6927	72	None	-7	27	Rat	8.3	pEC50	=	8.3	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
	CHEMBL39	6927	72	None	-7	27	Rat	8.3	pEC50	=	8.3	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
	DB08839	6927	72	None	-7	27	Rat	8.3	pEC50	=	8.3	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
	2543	10479	68	None	-2	14	Human	8.3	pEC50	=	8.3	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.bmcl.2003.09.025
	5358	10479	68	None	-2	14	Human	8.3	pEC50	=	8.3	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.bmcl.2003.09.025
	54	10479	68	None	-2	14	Human	8.3	pEC50	=	8.3	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.bmcl.2003.09.025
	CHEMBL128	10479	68	None	-2	14	Human	8.3	pEC50	=	8.3	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.bmcl.2003.09.025
	DB00669	10479	68	None	-2	14	Human	8.3	pEC50	=	8.3	Functional	Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.bmcl.2003.09.025
	9949172	17645	0	None	8	2	Human	7.3	pEC50	=	7.3	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	324	5	1	5	1.9	CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
	CHEMBL117249	17645	0	None	8	2	Human	7.3	pEC50	=	7.3	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	324	5	1	5	1.9	CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
	9949172	17645	0	None	8	2	Human	7.3	pEC50	=	7.3	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	324	5	1	5	1.9	CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	CHEMBL117249	17645	0	None	8	2	Human	7.3	pEC50	=	7.3	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	324	5	1	5	1.9	CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
	9890331	63141	0	None	14	2	Human	8.2	pEC50	=	8.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	457	8	2	6	3.5	CC(=O)Nc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	CHEMBL163127	63141	0	None	14	2	Human	8.2	pEC50	=	8.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	457	8	2	6	3.5	CC(=O)Nc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
	10740531	126644	0	None	31	2	Human	8.2	pEC50	=	8.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	9	2	5	3.4	c1ccc(CCNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	CHEMBL348815	126644	0	None	31	2	Human	8.2	pEC50	=	8.2	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	414	9	2	5	3.4	c1ccc(CCNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
	106	6936	26	None	234	2	Human	7.2	pEC50	=	7.2	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cellsCompound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cells	ChEMBL	302	11	2	2	4.8	CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2	10.1016/0960-894X(95)00091-7
	1797	6936	26	None	234	2	Human	7.2	pEC50	=	7.2	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cellsCompound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cells	ChEMBL	302	11	2	2	4.8	CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2	10.1016/0960-894X(95)00091-7
	CHEMBL97450	6936	26	None	234	2	Human	7.2	pEC50	=	7.2	Functional	Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cellsCompound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cells	ChEMBL	302	11	2	2	4.8	CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2	10.1016/0960-894X(95)00091-7
	9866484	63052	0	None	39	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	414	7	1	5	3.0	O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1	10.1021/jm980569z
	CHEMBL162899	63052	0	None	39	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	414	7	1	5	3.0	O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1	10.1021/jm980569z
	10780344	126714	0	None	11	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	297	4	2	5	1.4	O[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
	CHEMBL349528	126714	0	None	11	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	297	4	2	5	1.4	O[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
	10811801	126922	0	None	15	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	415	8	1	6	2.9	c1cncc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
	CHEMBL351311	126922	0	None	15	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	ChEMBL	415	8	1	6	2.9	c1cncc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
	10597901	17425	0	None	20	2	Human	8.1	pEC50	=	8.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	414	8	2	5	3.9	c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704558
	CHEMBL117046	17425	0	None	20	2	Human	8.1	pEC50	=	8.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	414	8	2	5	3.9	c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704558
	2393	10107	82	None	-2	9	Human	8.1	pEC50	=	8.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9704558
	5078	10107	82	None	-2	9	Human	8.1	pEC50	=	8.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9704558
	51	10107	82	None	-2	9	Human	8.1	pEC50	=	8.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9704558
	CHEMBL905	10107	82	None	-2	9	Human	8.1	pEC50	=	8.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9704558
	DB00953	10107	82	None	-2	9	Human	8.1	pEC50	=	8.1	Functional	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9704558
	10526642	176052	0	None	31	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	430	9	3	6	2.9	OC[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
	CHEMBL441296	176052	0	None	31	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	430	9	3	6	2.9	OC[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
	10614906	117282	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	310	4	1	5	1.5	CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
	CHEMBL324931	117282	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor	ChEMBL	310	4	1	5	1.5	CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
	10787241	61366	0	None	12	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	401	8	2	6	2.8	c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)ccn1	10.1021/jm9805687
	CHEMBL161066	61366	0	None	12	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor	ChEMBL	401	8	2	6	2.8	c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)ccn1	10.1021/jm9805687
	2543	10479	68	None	-2	14	Rat	7.0	pEC50	=	7.0	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	5358	10479	68	None	-2	14	Rat	7.0	pEC50	=	7.0	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	54	10479	68	None	-2	14	Rat	7.0	pEC50	=	7.0	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	CHEMBL128	10479	68	None	-2	14	Rat	7.0	pEC50	=	7.0	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	DB00669	10479	68	None	-2	14	Rat	7.0	pEC50	=	7.0	Functional	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	11668825	16363	0	None	199	2	Human	9.6	pED50	=	9.6	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	415	7	2	5	3.8	OC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	CHEMBL112507	16363	0	None	199	2	Human	9.6	pED50	=	9.6	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	415	7	2	5	3.8	OC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	15516682	17062	0	None	25	2	Human	9.1	pED50	=	9.1	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	450	7	2	6	3.6	CC1(C)CCCN(CC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)C1	10.1016/s0960-894x(99)00614-9
	CHEMBL116161	17062	0	None	25	2	Human	9.1	pED50	=	9.1	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	450	7	2	6	3.6	CC1(C)CCCN(CC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)C1	10.1016/s0960-894x(99)00614-9
	15516681	16974	0	None	21	2	Human	9.0	pED50	=	9.0	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	422	9	2	6	2.9	CN(CC1CC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	CHEMBL115989	16974	0	None	21	2	Human	9.0	pED50	=	9.0	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	422	9	2	6	2.9	CN(CC1CC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	5	6927	72	None	-5	27	Human	8.9	pED50	=	8.9	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00044a001
	5202	6927	72	None	-5	27	Human	8.9	pED50	=	8.9	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00044a001
	CHEMBL39	6927	72	None	-5	27	Human	8.9	pED50	=	8.9	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00044a001
	DB08839	6927	72	None	-5	27	Human	8.9	pED50	=	8.9	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00044a001
	44341707	16236	0	None	20	2	Human	8.9	pED50	=	8.9	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	464	9	2	6	4.0	CN(CC1CCCCC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	CHEMBL111899	16236	0	None	20	2	Human	8.9	pED50	=	8.9	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	464	9	2	6	4.0	CN(CC1CCCCC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	15516683	16844	0	None	36	2	Human	8.8	pED50	=	8.8	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	438	8	2	6	3.5	CN(CC(C)(C)C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	CHEMBL115352	16844	0	None	36	2	Human	8.8	pED50	=	8.8	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	438	8	2	6	3.5	CN(CC(C)(C)C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	10477461	120170	0	None	28	2	Human	8.8	pED50	=	8.8	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	424	9	2	6	3.1	CC(C)CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	CHEMBL331819	120170	0	None	28	2	Human	8.8	pED50	=	8.8	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	424	9	2	6	3.1	CC(C)CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	44341625	118094	0	None	2	2	Human	7.9	pED50	=	7.9	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	501	10	4	7	3.3	CC(=O)Nc1ccc(CNCC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1016/s0960-894x(99)00614-9
	CHEMBL326723	118094	0	None	2	2	Human	7.9	pED50	=	7.9	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	501	10	4	7	3.3	CC(=O)Nc1ccc(CNCC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1016/s0960-894x(99)00614-9
	11647963	117675	0	None	46	2	Human	8.7	pED50	=	8.7	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	444	9	3	6	3.3	OC1(CNCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	CHEMBL326125	117675	0	None	46	2	Human	8.7	pED50	=	8.7	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	444	9	3	6	3.3	OC1(CNCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	44341637	16373	0	None	16	2	Human	8.5	pED50	=	8.5	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	445	9	3	7	2.7	OC1(CNCc2ccccn2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	CHEMBL112558	16373	0	None	16	2	Human	8.5	pED50	=	8.5	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	445	9	3	7	2.7	OC1(CNCc2ccccn2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	44341609	16667	0	None	40	2	Human	8.4	pED50	=	8.4	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	472	9	2	6	3.9	Cc1ccccc1CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	CHEMBL114303	16667	0	None	40	2	Human	8.4	pED50	=	8.4	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	472	9	2	6	3.9	Cc1ccccc1CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	10456869	16764	0	None	44	2	Human	8.4	pED50	=	8.4	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	2	6	3.6	CN(Cc1ccccc1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	CHEMBL114877	16764	0	None	44	2	Human	8.4	pED50	=	8.4	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	2	6	3.6	CN(Cc1ccccc1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	2543	10479	68	None	-2	14	Human	6.5	pED50	=	6.5	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00044a001
	5358	10479	68	None	-2	14	Human	6.5	pED50	=	6.5	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00044a001
	54	10479	68	None	-2	14	Human	6.5	pED50	=	6.5	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00044a001
	CHEMBL128	10479	68	None	-2	14	Human	6.5	pED50	=	6.5	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00044a001
	DB00669	10479	68	None	-2	14	Human	6.5	pED50	=	6.5	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00044a001
	106	6936	26	None	234	2	Human	7.2	pED50	=	7.2	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	302	11	2	2	4.8	CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2	10.1021/jm00044a001
	1797	6936	26	None	234	2	Human	7.2	pED50	=	7.2	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	302	11	2	2	4.8	CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2	10.1021/jm00044a001
	CHEMBL97450	6936	26	None	234	2	Human	7.2	pED50	=	7.2	Functional	Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptorCompound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor	ChEMBL	302	11	2	2	4.8	CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2	10.1021/jm00044a001
	44341783	16871	1	None	23	2	Human	8.0	pED50	=	8.0	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	454	7	3	7	3.0	CC(C)(C)OC(=O)NCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	CHEMBL115496	16871	1	None	23	2	Human	8.0	pED50	=	8.0	Functional	Measurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist-induced [35S]-GTP gamma-S binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	454	7	3	7	3.0	CC(C)(C)OC(=O)NCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
	10621021	210163	0	None	66	2	Human	9.9	pIC50	=	9.9	Functional	Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayInhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assay	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/acs.jmedchem.7b01788
	CHEMBL65367	210163	0	None	66	2	Human	9.9	pIC50	=	9.9	Functional	Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayInhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assay	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/acs.jmedchem.7b01788
	18975369	107806	0	None	120	2	Human	9.5	pIC50	=	9.5	Functional	Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayInhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assay	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/acs.jmedchem.7b01788
	CHEMBL294547	107806	0	None	120	2	Human	9.5	pIC50	=	9.5	Functional	Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayInhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assay	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/acs.jmedchem.7b01788
	9844873	107835	0	None	48	2	Human	9.1	pIC50	=	9.1	Functional	Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayInhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assay	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/acs.jmedchem.7b01788
	CHEMBL294732	107835	0	None	48	2	Human	9.1	pIC50	=	9.1	Functional	Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayInhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assay	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/acs.jmedchem.7b01788
	11655728	23416	8	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	468	5	1	7	3.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241913	23416	8	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	468	5	1	7	3.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46899637	23432	0	None	-	0	Human	10.7	pKi	=	10.7	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	7	1	7	4.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NCC6CC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242345	23432	0	None	-	0	Human	10.7	pKi	=	10.7	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	7	1	7	4.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NCC6CC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900954	23424	0	None	-	0	Human	10.4	pKi	=	10.4	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	508	6	1	7	3.9	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242081	23424	0	None	-	0	Human	10.4	pKi	=	10.4	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	508	6	1	7	3.9	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	44138098	196251	0	None	-	0	Human	10.3	pKi	=	10.3	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL513715	196251	0	None	-	0	Human	10.3	pKi	=	10.3	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1021/jm100482n
	44138098	196251	0	None	-	0	Human	10.3	pKi	=	10.3	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL513715	196251	0	None	-	0	Human	10.3	pKi	=	10.3	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	44138098	196251	0	None	-	0	Human	10.3	pKi	=	10.3	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL513715	196251	0	None	-	0	Human	10.3	pKi	=	10.3	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	52947414	26073	0	None	-	0	Human	10.1	pKi	=	10.1	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	414	4	0	4	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1290487	26073	0	None	-	0	Human	10.1	pKi	=	10.1	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	414	4	0	4	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	44592296	185615	0	None	-	0	Human	10.1	pKi	=	10.1	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	434	4	0	5	3.4	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469374	185615	0	None	-	0	Human	10.1	pKi	=	10.1	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	434	4	0	5	3.4	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	10008868	127903	0	None	-	1	Human	10.1	pKi	=	10.1	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	609	12	5	7	3.4	NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12	10.1021/jm960552l
	CHEMBL357478	127903	0	None	-	1	Human	10.1	pKi	=	10.1	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	609	12	5	7	3.4	NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12	10.1021/jm960552l
	46900612	23408	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	467	5	0	7	4.2	CC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	CHEMBL1241736	23408	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	467	5	0	7	4.2	CC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	46900956	23426	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	6	1	7	4.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242167	23426	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	6	1	7	4.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900150	23468	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	425	4	0	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nccn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242904	23468	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	425	4	0	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nccn4-5)CC3)cccc2n1	10.1021/jm100482n
	9979309	199761	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL522257	199761	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1021/jm100482n
	52942551	26072	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	400	4	1	4	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1290486	26072	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	400	4	1	4	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	44138104	185612	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL469345	185612	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	9979309	199761	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL522257	199761	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	11797998	42466	0	None	-	1	Human	10.0	pKi	=	10.0	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	454	10	4	4	4.8	NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12	10.1021/jm960552l
	CHEMBL144030	42466	0	None	-	1	Human	10.0	pKi	=	10.0	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	454	10	4	4	4.8	NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12	10.1021/jm960552l
	11800592	127763	0	None	-	1	Human	10.0	pKi	=	10.0	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	540	12	6	6	3.7	NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12	10.1021/jm960552l
	CHEMBL356277	127763	0	None	-	1	Human	10.0	pKi	=	10.0	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	540	12	6	6	3.7	NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12	10.1021/jm960552l
	46900606	23397	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C)nnn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241546	23397	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C)nnn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900451	23398	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	439	4	0	6	4.3	Cc1cn2c(n1)COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	CHEMBL1241547	23398	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	439	4	0	6	4.3	Cc1cn2c(n1)COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	46900608	23403	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	427	4	0	8	2.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnnn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241639	23403	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	427	4	0	8	2.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnnn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900455	23405	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	493	4	0	6	5.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C(F)(F)F)cn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241641	23405	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	493	4	0	6	5.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C(F)(F)F)cn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900457	23406	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	425	4	0	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4cncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241642	23406	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	425	4	0	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4cncn4-5)CC3)cccc2n1	10.1021/jm100482n
	11712756	23415	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	482	5	1	7	3.3	CNC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	CHEMBL1241912	23415	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	482	5	1	7	3.3	CNC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	52947615	25908	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	444	4	0	5	4.3	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@H](C)C3)cc(F)cc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289394	25908	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	444	4	0	5	4.3	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@H](C)C3)cc(F)cc2n1	10.1016/j.bmcl.2010.09.085
	52942644	26114	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	398	4	1	4	3.7	Cc1ccc2c(N3CCN(CCc4cccc5[nH]c(=O)ccc45)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1290715	26114	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	398	4	1	4	3.7	Cc1ccc2c(N3CCN(CCc4cccc5[nH]c(=O)ccc45)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	46900453	23399	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	453	4	0	6	4.6	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C)c(C)n4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241548	23399	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	453	4	0	6	4.6	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C)c(C)n4-5)CC3)cccc2n1	10.1021/jm100482n
	46900459	23410	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnc(C)n4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241738	23410	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnc(C)n4-5)CC3)cccc2n1	10.1021/jm100482n
	46900776	23411	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	496	5	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N(C)C)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241824	23411	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	496	5	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N(C)C)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	11655728	23416	8	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	468	5	1	7	3.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241913	23416	8	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	468	5	1	7	3.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900782	23420	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	510	6	1	7	4.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC(C)C)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241998	23420	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	510	6	1	7	4.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC(C)C)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900958	23431	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	536	6	1	7	4.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242257	23431	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	536	6	1	7	4.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46899639	23441	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	5	0	7	4.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242533	23441	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	5	0	7	4.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46899640	23448	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	536	5	0	7	4.6	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242623	23448	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	536	5	0	7	4.6	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	11720815	23456	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	538	5	0	8	3.5	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCOCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242717	23456	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	538	5	0	8	3.5	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCOCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	44592250	185631	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	442	5	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C4CC4)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469568	185631	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	442	5	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C4CC4)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	10720301	46758	0	None	-	1	Human	9.8	pKi	=	9.8	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	504	11	4	6	2.3	NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12	10.1021/jm960552l
	CHEMBL147851	46758	0	None	-	1	Human	9.8	pKi	=	9.8	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	504	11	4	6	2.3	NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12	10.1021/jm960552l
	11797158	46814	0	None	-	1	Human	9.7	pKi	=	9.7	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	435	11	5	5	2.2	NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	CHEMBL147901	46814	0	None	-	1	Human	9.7	pKi	=	9.7	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	435	11	5	5	2.2	NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	46899638	23436	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	508	5	0	7	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242436	23436	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	508	5	0	7	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	44592209	185959	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	5	0	5	3.7	CCN1C(=O)COc2c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc21	10.1016/j.bmcl.2009.02.056
	CHEMBL472290	185959	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	5	0	5	3.7	CCN1C(=O)COc2c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc21	10.1016/j.bmcl.2009.02.056
	44592249	185630	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	444	5	0	5	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C(C)C)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469567	185630	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	444	5	0	5	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C(C)C)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	10531639	128050	0	None	-	1	Human	9.6	pKi	=	9.6	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	600	11	4	6	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12	10.1021/jm960552l
	CHEMBL357830	128050	0	None	-	1	Human	9.6	pKi	=	9.6	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	600	11	4	6	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12	10.1021/jm960552l
	10696930	42862	0	None	-	1	Human	9.5	pKi	=	9.5	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	506	14	6	6	1.7	NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	CHEMBL144397	42862	0	None	-	1	Human	9.5	pKi	=	9.5	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	506	14	6	6	1.7	NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	46900610	23404	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	497	6	0	8	4.2	CCOC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	CHEMBL1241640	23404	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	497	6	0	8	4.2	CCOC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	46900614	23409	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	496	6	0	8	4.4	CO/N=C(\C)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	CHEMBL1241737	23409	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	496	6	0	8	4.4	CO/N=C(\C)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	44138104	185612	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL469345	185612	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1021/jm100482n
	44138104	185612	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469345	185612	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	44592251	185686	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	456	6	0	5	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC4CC4)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469995	185686	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	456	6	0	5	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC4CC4)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	44592297	196269	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	448	4	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL513875	196269	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	448	4	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	3251	10844	58	None	-	4	Mouse	9.5	pKi	=	9.5	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm980456f
	5684	10844	58	None	-	4	Mouse	9.5	pKi	=	9.5	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm980456f
	80	10844	58	None	-	4	Mouse	9.5	pKi	=	9.5	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm980456f
	CHEMBL31354	10844	58	None	-	4	Mouse	9.5	pKi	=	9.5	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm980456f
	10791244	42571	0	None	-	1	Human	9.5	pKi	=	9.5	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	490	12	4	6	2.7	NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12	10.1021/jm960552l
	CHEMBL144128	42571	0	None	-	1	Human	9.5	pKi	=	9.5	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	490	12	4	6	2.7	NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12	10.1021/jm960552l
	10647387	46965	0	None	-	1	Human	9.5	pKi	=	9.5	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	454	10	4	4	4.8	NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12	10.1021/jm960552l
	CHEMBL148022	46965	0	None	-	1	Human	9.5	pKi	=	9.5	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	454	10	4	4	4.8	NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12	10.1021/jm960552l
	52943861	25873	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	430	4	0	5	3.9	Cc1ccc2c(N3CCN(CCc4c(F)ccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289163	25873	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	430	4	0	5	3.9	Cc1ccc2c(N3CCN(CCc4c(F)ccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	44592371	185773	0	None	-	1	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	5	1	5	3.6	Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL470849	185773	0	None	-	1	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	5	1	5	3.6	Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	44592252	195973	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	466	6	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC(F)F)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL511279	195973	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	466	6	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC(F)F)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	44592294	196042	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	4	0	5	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL511815	196042	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	4	0	5	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1	10.1016/j.bmcl.2009.02.056
	10837858	46580	0	None	-	1	Human	9.4	pKi	=	9.4	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	464	12	6	5	2.4	NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	CHEMBL147677	46580	0	None	-	1	Human	9.4	pKi	=	9.4	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	464	12	6	5	2.4	NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	9984109	45651	0	None	-	1	Human	9.4	pKi	=	9.4	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	518	10	4	6	1.8	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12	10.1021/jm960552l
	CHEMBL146720	45651	0	None	-	1	Human	9.4	pKi	=	9.4	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	518	10	4	6	1.8	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12	10.1021/jm960552l
	9897637	125710	0	None	-	1	Human	9.4	pKi	=	9.4	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	828	25	6	8	7.2	NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(-c4ccc(S(=O)(=O)NCCCCCCOc5ccc6[nH]cc(CCN)c6c5)cc4)cc3)cc12	10.1021/jm960552l
	CHEMBL342323	125710	0	None	-	1	Human	9.4	pKi	=	9.4	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	828	25	6	8	7.2	NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(-c4ccc(S(=O)(=O)NCCCCCCOc5ccc6[nH]cc(CCN)c6c5)cc4)cc3)cc12	10.1021/jm960552l
	10836606	172312	0	None	-	1	Human	9.3	pKi	=	9.3	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	434	13	4	4	4.7	NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	CHEMBL424128	172312	0	None	-	1	Human	9.3	pKi	=	9.3	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	434	13	4	4	4.7	NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	9909089	193747	0	None	-	1	Human	9.3	pKi	=	9.3	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL490417	193747	0	None	-	1	Human	9.3	pKi	=	9.3	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1021/jm100482n
	50908804	25943	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	5	4.5	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)C(C)(C)C3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289618	25943	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	5	4.5	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)C(C)(C)C3)cccc2n1	10.1016/j.bmcl.2010.09.085
	44592333	185617	0	None	-	1	Human	9.2	pKi	=	9.2	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	444	5	0	5	4.0	Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469376	185617	0	None	-	1	Human	9.2	pKi	=	9.2	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	444	5	0	5	4.0	Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1	10.1016/j.bmcl.2009.02.056
	44592207	196142	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL512724	196142	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	10809674	125974	0	None	-	1	Human	9.0	pKi	=	9	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	378	9	4	4	3.1	NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	CHEMBL343196	125974	0	None	-	1	Human	9.0	pKi	=	9	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	378	9	4	4	3.1	NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	24804774	26092	0	None	-	1	Human	9.0	pKi	=	9	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	428	4	0	4	4.1	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1290597	26092	0	None	-	1	Human	9.0	pKi	=	9	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	428	4	0	4	4.1	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	10048892	148209	2	None	-	0	Mouse	9.0	pKi	=	9.0	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, bindingReceptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding	ChEMBL	440	7	0	5	3.8	COc1ccccc1N1CCN(CCN(C(=O)C2CCC(F)CC2)c2ccccn2)CC1	10.1021/jm980456f
	CHEMBL38413	148209	2	None	-	0	Mouse	9.0	pKi	=	9.0	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, bindingReceptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding	ChEMBL	440	7	0	5	3.8	COc1ccccc1N1CCN(CCN(C(=O)C2CCC(F)CC2)c2ccccn2)CC1	10.1021/jm980456f
	3251	10844	58	None	-	4	Mouse	9.0	pKi	=	9.0	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm980456f
	5684	10844	58	None	-	4	Mouse	9.0	pKi	=	9.0	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm980456f
	80	10844	58	None	-	4	Mouse	9.0	pKi	=	9.0	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm980456f
	CHEMBL31354	10844	58	None	-	4	Mouse	9.0	pKi	=	9.0	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm980456f
	52947622	25925	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	444	4	0	5	4.3	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cc(F)cc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289510	25925	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	444	4	0	5	4.3	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cc(F)cc2n1	10.1016/j.bmcl.2010.09.085
	11797999	47299	0	None	-	1	Human	8.8	pKi	=	8.8	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	454	10	4	4	4.8	NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	CHEMBL148314	47299	0	None	-	1	Human	8.8	pKi	=	8.8	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	454	10	4	4	4.8	NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12	10.1021/jm960552l
	44592295	185788	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	4	0	5	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@@H](C)C3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL471047	185788	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	4	0	5	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@@H](C)C3)cccc2n1	10.1016/j.bmcl.2009.02.056
	10365683	119855	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	435	7	3	5	2.4	CC(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm960552l
	CHEMBL331240	119855	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	435	7	3	5	2.4	CC(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm960552l
	46900778	23412	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	450	4	0	7	3.9	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C#N)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241825	23412	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	450	4	0	7	3.9	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C#N)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	52948697	25855	0	None	-	1	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	426	4	0	5	4.1	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289048	25855	0	None	-	1	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	426	4	0	5	4.1	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	24804941	25888	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	444	4	0	5	4.2	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cc(F)cc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289276	25888	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	444	4	0	5	4.2	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cc(F)cc2n1	10.1016/j.bmcl.2010.09.085
	14519865	38361	1	None	-	0	Human	7.0	pKi	=	7.0	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	243	6	0	2	3.6	CCCN(C)CCOc1cccc2ccccc12	10.1021/jm970507t
	CHEMBL140417	38361	1	None	-	0	Human	7.0	pKi	=	7.0	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	243	6	0	2	3.6	CCCN(C)CCOc1cccc2ccccc12	10.1021/jm970507t
	6160690	126099	37	None	-	1	Human	7.0	pKi	=	7.0	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	377	8	2	3	3.6	COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1	10.1021/jm9604890
	CHEMBL344127	126099	37	None	-	1	Human	7.0	pKi	=	7.0	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	377	8	2	3	3.6	COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1	10.1021/jm9604890
	6422277	36809	5	None	-	0	Human	7.0	pKi	=	7.0	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	271	8	0	2	4.3	CCCCN(CC)CCOc1cccc2ccccc12	10.1021/jm970507t
	CHEMBL138907	36809	5	None	-	0	Human	7.0	pKi	=	7.0	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	271	8	0	2	4.3	CCCCN(CC)CCOc1cccc2ccccc12	10.1021/jm970507t
	10588458	34384	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	275	8	0	2	4.5	CCCN(C)CCCOc1ccccc1C1CCCC1	10.1021/jm970507t
	CHEMBL136962	34384	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	275	8	0	2	4.5	CCCN(C)CCCOc1ccccc1C1CCCC1	10.1021/jm970507t
	44592334	185636	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	448	5	0	5	3.8	Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469589	185636	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	448	5	0	5	3.8	Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	135516645	211889	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	241	3	4	4	2.0	Oc1ccc2[nH]cc(/C=N/Nc3ncc[nH]3)c2c1	10.1021/jm00013a010
	CHEMBL77734	211889	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	241	3	4	4	2.0	Oc1ccc2[nH]cc(/C=N/Nc3ncc[nH]3)c2c1	10.1021/jm00013a010
	37732	33596	73	None	-	0	Human	5.8	pKi	=	5.8	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	151	4	1	2	1.3	CNCCOc1ccccc1	10.1021/jm970507t
	CHEMBL136311	33596	73	None	-	0	Human	5.8	pKi	=	5.8	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	151	4	1	2	1.3	CNCCOc1ccccc1	10.1021/jm970507t
	10518850	41967	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	308	4	2	4	1.9	NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
	CHEMBL143512	41967	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	308	4	2	4	1.9	NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
	24804942	25924	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	5	4.5	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)[C@@H](C)C3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289509	25924	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	5	4.5	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)[C@@H](C)C3)cccc2n1	10.1016/j.bmcl.2010.09.085
	11584660	100043	8	None	-	5	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT1D receptorAntagonist activity at human 5HT1D receptor	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL244946	100043	8	None	-	5	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT1D receptorAntagonist activity at human 5HT1D receptor	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	52943811	25854	0	None	-	1	Human	8.6	pKi	=	8.6	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	412	4	1	4	4.1	Cc1ccc2c(N3CCN(CCc4c(C)ccc5[nH]c(=O)ccc45)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289047	25854	0	None	-	1	Human	8.6	pKi	=	8.6	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	412	4	1	4	4.1	Cc1ccc2c(N3CCN(CCc4c(C)ccc5[nH]c(=O)ccc45)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	52943891	25889	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	5	4.5	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)[C@H](C)C3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289277	25889	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	5	4.5	Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)[C@H](C)C3)cccc2n1	10.1016/j.bmcl.2010.09.085
	10623356	174908	0	None	-	0	Mouse	8.5	pKi	=	8.5	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)	ChEMBL	448	7	0	5	4.0	COc1ccccc1N1CCN(CCN(C(=O)c2ccc(F)c(C)c2)c2ccccn2)CC1	10.1021/jm980456f
	CHEMBL1910243	174908	0	None	-	0	Mouse	8.5	pKi	=	8.5	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)	ChEMBL	448	7	0	5	4.0	COc1ccccc1N1CCN(CCN(C(=O)c2ccc(F)c(C)c2)c2ccccn2)CC1	10.1021/jm980456f
	CHEMBL43297	174908	0	None	-	0	Mouse	8.5	pKi	=	8.5	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)	ChEMBL	448	7	0	5	4.0	COc1ccccc1N1CCN(CCN(C(=O)c2ccc(F)c(C)c2)c2ccccn2)CC1	10.1021/jm980456f
	135527031	211498	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	288	6	4	4	1.7	CCCCC/N=C(/N)N/N=C/c1c[nH]c2ccc(O)nc12	10.1021/jm00013a010
	CHEMBL74208	211498	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	288	6	4	4	1.7	CCCCC/N=C(/N)N/N=C/c1c[nH]c2ccc(O)nc12	10.1021/jm00013a010
	135464159	211609	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	329	8	3	3	3.4	CCCCC/N=C(/N)N/N=C/c1c[nH]c2ccc(OC(C)C)cc12	10.1021/jm00013a010
	CHEMBL75420	211609	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	329	8	3	3	3.4	CCCCC/N=C(/N)N/N=C/c1c[nH]c2ccc(OC(C)C)cc12	10.1021/jm00013a010
	10618751	41964	0	None	25	2	Human	7.5	pKi	=	7.5	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	364	7	1	4	3.3	CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
	CHEMBL143510	41964	0	None	25	2	Human	7.5	pKi	=	7.5	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	364	7	1	4	3.3	CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
	44592332	185616	0	None	-	1	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	5	0	5	3.7	Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469375	185616	0	None	-	1	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	5	0	5	3.7	Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	52946290	25874	0	None	-	1	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	446	4	0	5	4.4	Cc1ccc2c(N3CCN(CCc4c(Cl)ccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289164	25874	0	None	-	1	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	446	4	0	5	4.4	Cc1ccc2c(N3CCN(CCc4c(Cl)ccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	44592335	185704	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	462	5	0	5	4.2	Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL470217	185704	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	462	5	0	5	4.2	Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	2543	10479	68	None	-2	14	Human	7.5	pKi	=	7.5	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9604890
	5358	10479	68	None	-2	14	Human	7.5	pKi	=	7.5	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9604890
	54	10479	68	None	-2	14	Human	7.5	pKi	=	7.5	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9604890
	CHEMBL128	10479	68	None	-2	14	Human	7.5	pKi	=	7.5	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9604890
	DB00669	10479	68	None	-2	14	Human	7.5	pKi	=	7.5	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9604890
	9802530	42160	1	None	11	2	Human	7.5	pKi	=	7.5	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	336	5	1	4	2.5	CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
	CHEMBL143767	42160	1	None	11	2	Human	7.5	pKi	=	7.5	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	336	5	1	4	2.5	CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
	2199302	36872	25	None	-	0	Human	7.5	pKi	=	7.5	Functional	Compound was tested for its agonist activity against human 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	201	4	1	2	2.4	CNCCOc1cccc2ccccc12	10.1021/jm970507t
	CHEMBL138958	36872	25	None	-	0	Human	7.5	pKi	=	7.5	Functional	Compound was tested for its agonist activity against human 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	201	4	1	2	2.4	CNCCOc1cccc2ccccc12	10.1021/jm970507t
	10691904	42394	0	None	3	2	Human	7.4	pKi	=	7.4	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	392	9	1	4	4.1	CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
	CHEMBL143967	42394	0	None	3	2	Human	7.4	pKi	=	7.4	Functional	Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.	ChEMBL	392	9	1	4	4.1	CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
	50908805	25959	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	425	4	0	4	5.1	Cc1ccc2c(C3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1289721	25959	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	425	4	0	4	5.1	Cc1ccc2c(C3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	10623356	174908	0	None	-	0	Mouse	8.4	pKi	=	8.4	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)	ChEMBL	448	7	0	5	4.0	COc1ccccc1N1CCN(CCN(C(=O)c2ccc(F)c(C)c2)c2ccccn2)CC1	10.1021/jm980456f
	CHEMBL1910243	174908	0	None	-	0	Mouse	8.4	pKi	=	8.4	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)	ChEMBL	448	7	0	5	4.0	COc1ccccc1N1CCN(CCN(C(=O)c2ccc(F)c(C)c2)c2ccccn2)CC1	10.1021/jm980456f
	CHEMBL43297	174908	0	None	-	0	Mouse	8.4	pKi	=	8.4	Functional	Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 1)	ChEMBL	448	7	0	5	4.0	COc1ccccc1N1CCN(CCN(C(=O)c2ccc(F)c(C)c2)c2ccccn2)CC1	10.1021/jm980456f
	52944840	25750	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	426	4	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1287827	25750	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	426	4	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cccc2n1	10.1016/j.bmcl.2010.09.085
	44592208	185958	0	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL472289	185958	0	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	5	6927	72	None	-5	27	Human	8.3	pKi	=	8.3	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm960552l
	5202	6927	72	None	-5	27	Human	8.3	pKi	=	8.3	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm960552l
	CHEMBL39	6927	72	None	-5	27	Human	8.3	pKi	=	8.3	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm960552l
	DB08839	6927	72	None	-5	27	Human	8.3	pKi	=	8.3	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm960552l
	135404909	20340	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	389	5	4	3	3.7	N/C(=N/N=C/c1c[nH]c2ccc(O)cc12)NCCc1ccc(Cl)c(Cl)c1	10.1021/jm00013a010
	CHEMBL1193970	20340	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	389	5	4	3	3.7	N/C(=N/N=C/c1c[nH]c2ccc(O)cc12)NCCc1ccc(Cl)c(Cl)c1	10.1021/jm00013a010
	CHEMBL545461	20340	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	389	5	4	3	3.7	N/C(=N/N=C/c1c[nH]c2ccc(O)cc12)NCCc1ccc(Cl)c(Cl)c1	10.1021/jm00013a010
	1328538	38358	8	None	-	0	Human	6.2	pKi	=	6.2	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	291	6	0	2	4.4	CN(CCOc1cccc2ccccc12)Cc1ccccc1	10.1021/jm970507t
	CHEMBL140416	38358	8	None	-	0	Human	6.2	pKi	=	6.2	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	291	6	0	2	4.4	CN(CCOc1cccc2ccccc12)Cc1ccccc1	10.1021/jm970507t
	2261792	123225	6	None	-	0	Human	7.2	pKi	=	7.2	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	231	6	2	3	1.8	OCCNCCOc1cccc2ccccc12	10.1021/jm970507t
	CHEMBL336092	123225	6	None	-	0	Human	7.2	pKi	=	7.2	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	231	6	2	3	1.8	OCCNCCOc1cccc2ccccc12	10.1021/jm970507t
	2543	10479	68	None	-2	14	Human	8.1	pKi	=	8.1	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm960552l
	5358	10479	68	None	-2	14	Human	8.1	pKi	=	8.1	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm960552l
	54	10479	68	None	-2	14	Human	8.1	pKi	=	8.1	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm960552l
	CHEMBL128	10479	68	None	-2	14	Human	8.1	pKi	=	8.1	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm960552l
	DB00669	10479	68	None	-2	14	Human	8.1	pKi	=	8.1	Functional	Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm960552l
	10635169	38356	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	261	7	0	2	4.1	CCCN(C)CCOc1ccccc1C1CCCC1	10.1021/jm970507t
	CHEMBL140415	38356	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose.	ChEMBL	261	7	0	2	4.1	CCCN(C)CCOc1ccccc1C1CCCC1	10.1021/jm970507t
	135516796	211756	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	329	8	4	3	3.6	CCCCCCCN(C)C(=N)N/N=C/c1c[nH]c2ccc(O)cc12	10.1021/jm00013a010
	135802977	211756	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	329	8	4	3	3.6	CCCCCCCN(C)C(=N)N/N=C/c1c[nH]c2ccc(O)cc12	10.1021/jm00013a010
	CHEMBL76552	211756	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	329	8	4	3	3.6	CCCCCCCN(C)C(=N)N/N=C/c1c[nH]c2ccc(O)cc12	10.1021/jm00013a010
	135410312	210281	1	None	-	0	Human	8.0	pKi	=	8.0	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	287	6	5	3	2.5	CCCCCNC(=N)N/N=C/c1c[nH]c2ccc(O)cc12	10.1021/jm00013a010
	CHEMBL6621	210281	1	None	-	0	Human	8.0	pKi	=	8.0	Functional	Agonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTIAgonistic activity against 5-hydroxytryptamine 1D receptor in calf caudate using [3H]-GTI	ChEMBL	287	6	5	3	2.5	CCCCCNC(=N)N/N=C/c1c[nH]c2ccc(O)cc12	10.1021/jm00013a010
	1884	9512	58	None	-	1	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	None
	4440	9512	58	None	-	1	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	None
	45	9512	58	None	-	1	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	None
	CHEMBL1278	9512	58	None	-	1	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	None
	DB00952	9512	58	None	-	1	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	None
	1042	8362	23	None	-3	13	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	148	8362	23	None	-3	13	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	443884	8362	23	None	-3	13	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	CHEMBL119443	8362	23	None	-3	13	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	DB01253	8362	23	None	-3	13	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	4223	10764	94	None	-645	15	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314	10764	94	None	-645	15	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	7427	10764	94	None	-645	15	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	CHEMBL439849	10764	94	None	-645	15	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	DB06684	10764	94	None	-645	15	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	4806	10780	88	None	-1	3	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	7351	10780	88	None	-1	3	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	9966051	10780	88	None	-1	3	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	CHEMBL2104993	10780	88	None	-1	3	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	DB09068	10780	88	None	-1	3	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	4806	10780	88	None	-1	3	Rat	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	15341484
	7351	10780	88	None	-1	3	Rat	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	15341484
	9966051	10780	88	None	-1	3	Rat	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	15341484
	CHEMBL2104993	10780	88	None	-1	3	Rat	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	15341484
	DB09068	10780	88	None	-1	3	Rat	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	15341484
	137	6926	0	None	1	2	Human	12.0	pIC50	None	12	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9774213
	7048565	6926	0	None	1	2	Human	12.0	pIC50	None	12	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9774213
	7048566	6926	0	None	1	2	Human	12.0	pIC50	None	12	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9774213
	110	7957	18	None	1	2	Human	7.7	pIC50	None	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	321	5	2	3	1.9	CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C	9303569
	132552	7957	18	None	1	2	Human	7.7	pIC50	None	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	321	5	2	3	1.9	CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C	9303569
	CHEMBL159332	7957	18	None	1	2	Human	7.7	pIC50	None	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	321	5	2	3	1.9	CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C	9303569
	122	8219	9	None	1412	2	Human	7.9	pIC50	None	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	1565658
	156314	8219	9	None	1412	2	Human	7.9	pIC50	None	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	1565658
	CHEMBL1332062	8219	9	None	1412	2	Human	7.9	pIC50	None	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	1565658
	16	9033	8	None	69	5	Human	9.0	pIC50	None	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10585208
	9847194	9033	8	None	69	5	Human	9.0	pIC50	None	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10585208
	CHEMBL313714	9033	8	None	69	5	Human	9.0	pIC50	None	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10585208

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		9950538	211637	0	None	-	0	Guinea pig	10.4	pEC50	=	10.4	Binding	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra	ChEMBL	355	3	1	4	4.0	CN1CCC[C@@H]1Cc1c[nH]c2ccc(-n3cnc4cc(C#N)ccc43)cc12	10.1016/0960-894X(95)00417-R
		CHEMBL75642	211637	0	None	-	0	Guinea pig	10.4	pEC50	=	10.4	Binding	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra	ChEMBL	355	3	1	4	4.0	CN1CCC[C@@H]1Cc1c[nH]c2ccc(-n3cnc4cc(C#N)ccc43)cc12	10.1016/0960-894X(95)00417-R
		10813272	45093	0	None	-	0	Human	9.3	pEC50	=	9.3	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	446	8	2	5	4.6	CC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm9910021
		CHEMBL146285	45093	0	None	-	0	Human	9.3	pEC50	=	9.3	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	446	8	2	5	4.6	CC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm9910021
		16	9033	8	None	-	1	Human	9.1	pEC50	=	9.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
		9847194	9033	8	None	-	1	Human	9.1	pEC50	=	9.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
		CHEMBL313714	9033	8	None	-	1	Human	9.1	pEC50	=	9.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
		10836986	175086	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	443	9	3	5	4.1	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL434125	175086	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	443	9	3	5	4.1	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10766318	44547	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	10	2	6	4.1	COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL145815	44547	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	10	2	6	4.1	COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10765655	121223	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	442	9	1	5	4.5	CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL333341	121223	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	442	9	1	5	4.5	CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10527882	42367	0	None	-	0	Human	9.0	pEC50	=	9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	3	6	3.9	C[C@@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL143947	42367	0	None	-	0	Human	9.0	pEC50	=	9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	3	6	3.9	C[C@@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10623614	127828	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	454	8	2	5	4.7	c1ccc2c(c1)CCC2NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL356808	127828	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	454	8	2	5	4.7	c1ccc2c(c1)CCC2NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		11796806	109494	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL304857	109494	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10646958	18179	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL118012	18179	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		11795644	47207	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	406	8	1	5	4.0	CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL148233	47207	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	406	8	1	5	4.0	CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10551857	172151	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	2	6	3.8	CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1	10.1021/jm9910021
		CHEMBL423749	172151	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	2	6	3.8	CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1	10.1021/jm9910021
		2543	10479	68	None	-1	32	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9910021
		5358	10479	68	None	-1	32	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9910021
		54	10479	68	None	-1	32	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9910021
		CHEMBL128	10479	68	None	-1	32	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9910021
		DB00669	10479	68	None	-1	32	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9910021
		10719448	42377	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	478	9	2	6	3.4	O=S(=O)(NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL143952	42377	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	478	9	2	6	3.4	O=S(=O)(NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10526567	47042	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	2	5	4.5	C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL148087	47042	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	2	5	4.5	C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10835665	45665	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	415	8	2	6	3.3	c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1	10.1021/jm9910021
		CHEMBL146729	45665	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	415	8	2	6	3.3	c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1	10.1021/jm9910021
		10766235	85635	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	456	7	3	6	3.4	O[C@@H]1Cc2ccccc2[C@H]1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL2112862	85635	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	456	7	3	6	3.4	O[C@@H]1Cc2ccccc2[C@H]1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10764998	120266	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL331970	120266	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10790076	46762	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	10	3	6	3.3	OC[C@@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL147853	46762	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	10	3	6	3.3	OC[C@@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		11722647	212201	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra	ChEMBL	305	4	1	4	3.0	CN(C)CCc1c[nH]c2ccc(-n3cnc4cccnc43)cc12	10.1016/0960-894X(95)00417-R
		CHEMBL80189	212201	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra	ChEMBL	305	4	1	4	3.0	CN(C)CCc1c[nH]c2ccc(-n3cnc4cccnc43)cc12	10.1016/0960-894X(95)00417-R
		11798621	47073	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	471	9	3	6	3.8	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1	10.1021/jm9910021
		CHEMBL148110	47073	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	471	9	3	6	3.8	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1	10.1021/jm9910021
		10504095	172040	1	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	3	6	3.9	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](O)c1ccccc1	10.1021/jm9910021
		CHEMBL423022	172040	1	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	3	6	3.9	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](O)c1ccccc1	10.1021/jm9910021
		5	6927	72	None	-	53	Guinea pig	7.8	pEC50	=	7.8	Binding	Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigraInhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigra	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00170a007
		5202	6927	72	None	-	53	Guinea pig	7.8	pEC50	=	7.8	Binding	Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigraInhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigra	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00170a007
		CHEMBL39	6927	72	None	-	53	Guinea pig	7.8	pEC50	=	7.8	Binding	Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigraInhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigra	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00170a007
		DB08839	6927	72	None	-	53	Guinea pig	7.8	pEC50	=	7.8	Binding	Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigraInhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigra	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00170a007
		10550488	42429	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL144002	42429	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10741826	45973	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	441	6	2	7	4.1	Oc1nc2ccccc2n1C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL146991	45973	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	441	6	2	7	4.1	Oc1nc2ccccc2n1C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10468938	17016	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Compound was tested for measuring agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorCompound was tested for measuring agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9910021
		CHEMBL116092	17016	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Compound was tested for measuring agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorCompound was tested for measuring agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9910021
		11797562	44917	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	444	9	3	6	3.5	OC[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL146132	44917	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	444	9	3	6	3.5	OC[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10577311	46566	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	499	10	2	6	4.5	CC(=O)Nc1ccc(CN(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL147660	46566	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	499	10	2	6	4.5	CC(=O)Nc1ccc(CN(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		2543	10479	68	None	-1	32	Human	6.7	pEC50	=	6.7	Binding	Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm970513p
		5358	10479	68	None	-1	32	Human	6.7	pEC50	=	6.7	Binding	Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm970513p
		54	10479	68	None	-1	32	Human	6.7	pEC50	=	6.7	Binding	Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm970513p
		CHEMBL128	10479	68	None	-1	32	Human	6.7	pEC50	=	6.7	Binding	Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm970513p
		DB00669	10479	68	None	-1	32	Human	6.7	pEC50	=	6.7	Binding	Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm970513p
		10836850	47051	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	440	7	2	5	4.4	c1ccc2c(c1)CCC2NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL148095	47051	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	440	7	2	5	4.4	c1ccc2c(c1)CCC2NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10720175	45344	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	499	10	3	6	4.7	CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL146483	45344	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	499	10	3	6	4.7	CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10504097	47167	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	3	6	3.6	CC(CO)(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL148194	47167	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	3	6	3.6	CC(CO)(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10717709	172061	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	434	8	1	6	4.3	CN(Cc1cccs1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL423212	172061	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	434	8	1	6	4.3	CN(Cc1cccs1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10718714	44916	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	10	3	6	3.3	OC[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL146131	44916	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	10	3	6	3.3	OC[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10813769	127767	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	3	6	3.9	C[C@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL356315	127767	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	9	3	6	3.9	C[C@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		46881468	13631	0	None	-	3	Human	5.5	pEC50	=	5.5	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	245	3	1	3	1.9	c1ccc(N2CCN(CC3CCCCN3)C2)cc1	10.1016/j.bmcl.2010.01.090
		CHEMBL1084132	13631	0	None	-	3	Human	5.5	pEC50	=	5.5	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	245	3	1	3	1.9	c1ccc(N2CCN(CC3CCCCN3)C2)cc1	10.1016/j.bmcl.2010.01.090
		10837591	125539	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	10	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL341854	125539	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	10	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10502988	44786	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	434	8	1	6	4.3	CN(Cc1ccsc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL146024	44786	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	434	8	1	6	4.3	CN(Cc1ccsc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10552243	46743	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	468	7	1	5	5.4	c1ccc(C2CCCCN2C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL147838	46743	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	468	7	1	5	5.4	c1ccc(C2CCCCN2C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10719203	45153	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	471	9	3	6	3.9	CC(=O)Nc1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL146335	45153	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	471	9	3	6	3.9	CC(=O)Nc1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10766319	45532	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	10	3	6	3.9	OCCC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL146628	45532	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	458	10	3	6	3.9	OCCC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10812465	42305	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	428	9	2	5	4.2	c1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL143893	42305	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	428	9	2	5	4.2	c1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		46881463	13990	0	None	-	5	Human	6.3	pEC50	=	6.3	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	293	3	1	2	2.7	O=C1N(CC2CCCCN2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
		CHEMBL1085672	13990	0	None	-	5	Human	6.3	pEC50	=	6.3	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	293	3	1	2	2.7	O=C1N(CC2CCCCN2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
		10552573	44915	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	476	10	4	5	3.5	O=C1N[C@@H](Cc2ccc3[nH]cc(CCCN4CCC(N[C@@H](CO)c5ccccc5)CC4)c3c2)CO1	10.1021/jm9910021
		CHEMBL146129	44915	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	476	10	4	5	3.5	O=C1N[C@@H](Cc2ccc3[nH]cc(CCCN4CCC(N[C@@H](CO)c5ccccc5)CC4)c3c2)CO1	10.1021/jm9910021
		10788620	46821	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	427	8	2	4	5.1	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL147907	46821	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	427	8	2	4	5.1	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10551207	45372	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	442	9	2	5	4.4	C[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL146502	45372	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	442	9	2	5	4.4	C[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		11795525	127894	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	404	8	2	6	3.5	c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1	10.1021/jm9910021
		CHEMBL357408	127894	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	404	8	2	6	3.5	c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1	10.1021/jm9910021
		10646959	46889	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL147961	46889	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10597901	17425	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	2	5	3.9	c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL117046	17425	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	414	8	2	5	3.9	c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		5	6927	72	None	-	53	Guinea pig	8.1	pEC50	=	8.1	Binding	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
		5202	6927	72	None	-	53	Guinea pig	8.1	pEC50	=	8.1	Binding	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
		CHEMBL39	6927	72	None	-	53	Guinea pig	8.1	pEC50	=	8.1	Binding	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
		DB08839	6927	72	None	-	53	Guinea pig	8.1	pEC50	=	8.1	Binding	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
		10645715	47037	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	418	8	1	6	3.9	CN(Cc1ccoc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL148085	47037	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	418	8	1	6	3.9	CN(Cc1ccoc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10601144	126166	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	490	11	2	6	4.3	COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccc(F)cc1	10.1021/jm9910021
		CHEMBL344537	126166	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	490	11	2	6	4.3	COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccc(F)cc1	10.1021/jm9910021
		10838684	125918	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	487	10	3	7	3.6	NC(=O)OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL342805	125918	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	ChEMBL	487	10	3	7	3.6	NC(=O)OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		9851789	92297	0	None	-	0	Human	10.3	pIC50	=	10.3	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	606	14	6	4	6.5	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1021/jm7011722
		CHEMBL22744	92297	0	None	-	0	Human	10.3	pIC50	=	10.3	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	606	14	6	4	6.5	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1021/jm7011722
		9851789	92297	0	None	-	0	Human	10.3	pIC50	=	10.3	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	606	14	6	4	6.5	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		CHEMBL22744	92297	0	None	-	0	Human	10.3	pIC50	=	10.3	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	606	14	6	4	6.5	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		11668825	16363	0	None	-	0	Human	10.0	pIC50	=	10	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	415	7	2	5	3.8	OC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL112507	16363	0	None	-	0	Human	10.0	pIC50	=	10	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	415	7	2	5	3.8	OC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10716915	61919	0	None	-	0	Human	10.0	pIC50	=	10	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	418	7	1	5	3.6	Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL161723	61919	0	None	-	0	Human	10.0	pIC50	=	10	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	418	7	1	5	3.6	Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		10621021	210163	0	None	-	0	Human	10.0	pIC50	=	10	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL65367	210163	0	None	-	0	Human	10.0	pIC50	=	10	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		10550857	210225	0	None	-	0	Human	10.0	pIC50	=	10	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	435	7	1	4	4.9	Fc1ccccc1CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		CHEMBL65824	210225	0	None	-	0	Human	10.0	pIC50	=	10	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	435	7	1	4	4.9	Fc1ccccc1CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		10009042	92585	0	None	-	0	Human	10.0	pIC50	=	10.0	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	620	15	6	4	6.9	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		CHEMBL22961	92585	0	None	-	0	Human	10.0	pIC50	=	10.0	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	620	15	6	4	6.9	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		10621021	210163	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/acs.jmedchem.5b00258
		CHEMBL65367	210163	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/acs.jmedchem.5b00258
		10621021	210163	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm981133m
		CHEMBL65367	210163	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm981133m
		11798094	61493	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	457	8	2	6	3.5	CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
		CHEMBL161176	61493	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	457	8	2	6	3.5	CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
		44214559	63272	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	443	8	2	6	2.5	NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		CHEMBL163462	63272	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	443	8	2	6	2.5	NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		10621021	210163	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
		10621021	210163	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980204e
		CHEMBL65367	210163	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
		CHEMBL65367	210163	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	7	1	5	3.5	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980204e
		11797644	60197	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique	ChEMBL	446	9	3	4	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1	10.1021/jm9805687
		CHEMBL160070	60197	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique	ChEMBL	446	9	3	4	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1	10.1021/jm9805687
		9881526	108025	1	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9704558
		CHEMBL296161	108025	1	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9704558
		18975369	107806	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/acs.jmedchem.5b00258
		CHEMBL294547	107806	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/acs.jmedchem.5b00258
		9881526	108025	1	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm980569z
		CHEMBL296161	108025	1	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm980569z
		11797644	60197	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	446	9	3	4	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1	10.1021/jm9805687
		CHEMBL160070	60197	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	446	9	3	4	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1	10.1021/jm9805687
		9881526	108025	1	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9805687
		CHEMBL296161	108025	1	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	255	4	1	4	1.9	CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9805687
		10834909	171699	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	7	1	6	2.9	c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
		CHEMBL422366	171699	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	7	1	6	2.9	c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
		18975369	107806	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm981133m
		CHEMBL294547	107806	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm981133m
		10719687	209778	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	485	7	1	4	5.7	FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		CHEMBL63167	209778	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	485	7	1	4	5.7	FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		44213966	213506	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	330	7	3	5	1.9	CCc1ccc2c(c1)OC(CNCCCNC1=NCCCN1)CC2	10.1016/0960-894X(95)00473-7
		CHEMBL89878	213506	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	330	7	3	5	1.9	CCc1ccc2c(c1)OC(CNCCCNC1=NCCCN1)CC2	10.1016/0960-894X(95)00473-7
		44458239	92583	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	676	19	6	4	8.5	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		CHEMBL22960	92583	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	676	19	6	4	8.5	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		10252256	59551	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique	ChEMBL	432	9	3	4	3.5	O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1	10.1021/jm9805687
		CHEMBL159483	59551	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique	ChEMBL	432	9	3	4	3.5	O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1	10.1021/jm9805687
		10764998	120266	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9704558
		CHEMBL331970	120266	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9704558
		10252256	59551	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	432	9	3	4	3.5	O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1	10.1021/jm9805687
		CHEMBL159483	59551	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	432	9	3	4	3.5	O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1	10.1021/jm9805687
		18975369	107806	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980204e
		CHEMBL294547	107806	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	399	7	1	4	4.6	c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980204e
		10764998	120266	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL331970	120266	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10620429	63038	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	390	7	1	6	3.1	c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
		CHEMBL162805	63038	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	390	7	1	6	3.1	c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
		10644750	63286	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	7	1	6	2.9	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm980569z
		CHEMBL163573	63286	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	7	1	6	2.9	c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm980569z
		10670534	210215	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	435	7	1	4	4.9	Fc1cccc(CC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		CHEMBL65765	210215	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	435	7	1	4	4.9	Fc1cccc(CC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		11647963	117675	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	444	9	3	6	3.3	OC1(CNCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL326125	117675	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	444	9	3	6	3.3	OC1(CNCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10693140	59853	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	2	5	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
		CHEMBL159759	59853	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	2	5	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
		11794750	126682	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	390	8	2	6	3.0	c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1	10.1021/jm9805687
		CHEMBL349185	126682	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	390	8	2	6	3.0	c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1	10.1021/jm9805687
		10386282	170879	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL420965	170879	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		10386282	170879	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
		CHEMBL420965	170879	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
		10386282	170879	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL420965	170879	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		11795644	47207	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	406	8	1	5	4.0	CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL148233	47207	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	406	8	1	5	4.0	CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		114	9034	14	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980569z
		6426760	9034	14	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980569z
		CHEMBL292779	9034	14	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980569z
		10526736	16994	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		CHEMBL116031	16994	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		10741528	61885	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	434	7	1	5	4.2	Clc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL161696	61885	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	434	7	1	5	4.2	Clc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		114	9034	14	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm981133m
		6426760	9034	14	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm981133m
		CHEMBL292779	9034	14	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm981133m
		10386282	170879	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1016/s0960-894x(99)00409-6
		CHEMBL420965	170879	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1016/s0960-894x(99)00409-6
		10526567	47042	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	428	8	2	5	4.5	C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL148087	47042	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	428	8	2	5	4.5	C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		114	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704560
		6426760	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704560
		CHEMBL292779	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704560
		10386282	170879	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm980569z
		CHEMBL420965	170879	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm980569z
		10720175	45344	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	499	10	3	6	4.7	CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL146483	45344	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	499	10	3	6	4.7	CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10577311	46566	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	499	10	2	6	4.5	CC(=O)Nc1ccc(CN(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL147660	46566	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	499	10	2	6	4.5	CC(=O)Nc1ccc(CN(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		9952249	59446	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	388	6	1	7	2.3	c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm980569z
		CHEMBL159396	59446	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	388	6	1	7	2.3	c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm980569z
		11795333	63045	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	7	1	6	2.9	c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1	10.1021/jm980569z
		CHEMBL162858	63045	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	7	1	6	2.9	c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1	10.1021/jm980569z
		114	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704560
		114	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
		6426760	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704560
		6426760	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
		CHEMBL292779	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704560
		CHEMBL292779	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
		10526736	16994	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
		CHEMBL116031	16994	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
		114	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm7011722
		6426760	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm7011722
		CHEMBL292779	9034	14	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	432	8	1	5	3.7	Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm7011722
		10551328	210500	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	445	8	1	4	5.7	CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm981133m
		CHEMBL67684	210500	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	445	8	1	4	5.7	CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm981133m
		15516682	17062	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	450	7	2	6	3.6	CC1(C)CCCN(CC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)C1	10.1016/s0960-894x(99)00614-9
		CHEMBL116161	17062	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	450	7	2	6	3.6	CC1(C)CCCN(CC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)C1	10.1016/s0960-894x(99)00614-9
		10477461	120170	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	424	9	2	6	3.1	CC(C)CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL331819	120170	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	424	9	2	6	3.1	CC(C)CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10476740	212875	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	411	5	1	4	4.1	CN1[C@@H](Cc2c[nH]c3ccc(-n4ccnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
		CHEMBL85668	212875	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	411	5	1	4	4.1	CN1[C@@H](Cc2c[nH]c3ccc(-n4ccnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
		10501944	17809	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	414	8	1	5	3.7	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9704558
		CHEMBL117579	17809	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	414	8	1	5	3.7	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9704558
		10501944	17809	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	1	5	3.7	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		CHEMBL117579	17809	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	1	5	3.7	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		10670879	126646	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	442	9	1	5	4.4	C[C@@H](c1ccccc1)N(C)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1	10.1021/jm9805687
		CHEMBL348864	126646	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	442	9	1	5	4.4	C[C@@H](c1ccccc1)N(C)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1	10.1021/jm9805687
		10836986	175086	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	443	9	3	5	4.1	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL434125	175086	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	443	9	3	5	4.1	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10788768	63269	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	430	8	2	6	3.0	OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		CHEMBL163386	63269	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	430	8	2	6	3.0	OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		10764869	126515	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	425	7	1	6	3.4	N#Cc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL347665	126515	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	425	7	1	6	3.4	N#Cc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		10503731	17061	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.8	Fc1cc(F)cc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm9704560
		CHEMBL116153	17061	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.8	Fc1cc(F)cc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm9704560
		10503687	209856	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	449	8	1	4	5.3	Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		CHEMBL63799	209856	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	449	8	1	4	5.3	Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		10501945	61708	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	2	5	4.0	C[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
		CHEMBL161410	61708	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	2	5	4.0	C[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
		10503687	209856	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	449	8	1	4	5.3	Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980204e
		CHEMBL63799	209856	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	449	8	1	4	5.3	Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980204e
		44213968	213271	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	332	7	3	6	1.3	COc1cccc2c1OC(CNCCCNC1=NCCCN1)CC2	10.1016/0960-894X(95)00473-7
		CHEMBL88283	213271	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	332	7	3	6	1.3	COc1cccc2c1OC(CNCCCNC1=NCCCN1)CC2	10.1016/0960-894X(95)00473-7
		15521391	212460	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	430	5	1	5	3.6	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccc(F)cc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
		CHEMBL82204	212460	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	430	5	1	5	3.6	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccc(F)cc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
		10597902	59774	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	1	5	3.9	CN(Cc1ccccc1)C[C@@H]1CCCN1CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9805687
		CHEMBL159683	59774	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	1	5	3.9	CN(Cc1ccccc1)C[C@@H]1CCCN1CCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm9805687
		10574762	16915	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL115750	16915	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		10574570	63006	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	1	5	4.1	CC(CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm980569z
		CHEMBL162722	63006	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	1	5	4.1	CC(CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm980569z
		10574671	127003	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	430	7	1	5	3.8	S=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1	10.1021/jm980569z
		CHEMBL352159	127003	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	430	7	1	5	3.8	S=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1	10.1021/jm980569z
		10574762	16915	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
		CHEMBL115750	16915	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.7	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
		10813413	210460	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	449	8	1	4	5.3	Fc1ccccc1CCC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		CHEMBL67460	210460	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	449	8	1	4	5.3	Fc1ccccc1CCC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		10787240	126584	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	1	5	4.0	c1ccc(COC[C@@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1	10.1021/jm9805687
		CHEMBL348304	126584	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	1	5	4.0	c1ccc(COC[C@@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1	10.1021/jm9805687
		44458044	90002	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	592	13	6	4	6.2	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		CHEMBL21862	90002	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	592	13	6	4	6.2	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		10319498	212612	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	412	5	1	5	3.5	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
		CHEMBL83426	212612	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	412	5	1	5	3.5	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
		15521385	212693	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	413	7	1	4	4.3	CN(Cc1ccccc1)C[C@H]1C[C@H](Cc2c[nH]c3ccc(-n4ccnc4)cc23)N(C)C1	10.1016/s0960-894x(99)00409-6
		CHEMBL84070	212693	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	413	7	1	4	4.3	CN(Cc1ccccc1)C[C@H]1C[C@H](Cc2c[nH]c3ccc(-n4ccnc4)cc23)N(C)C1	10.1016/s0960-894x(99)00409-6
		16	9033	8	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704558
		9847194	9033	8	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704558
		CHEMBL313714	9033	8	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9704558
		9844873	107835	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/acs.jmedchem.5b00258
		CHEMBL294732	107835	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/acs.jmedchem.5b00258
		16	9033	8	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
		9847194	9033	8	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
		CHEMBL313714	9033	8	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
		10527882	42367	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	458	9	3	6	3.9	C[C@@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL143947	42367	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	458	9	3	6	3.9	C[C@@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10765655	121223	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	442	9	1	5	4.5	CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL333341	121223	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	442	9	1	5	4.5	CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		6426761	20729	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	450	8	1	5	3.8	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F	10.1021/jm980569z
		CHEMBL119668	20729	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	450	8	1	5	3.8	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F	10.1021/jm980569z
		10789399	126652	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	443	9	2	6	3.3	CNCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		CHEMBL348962	126652	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	443	9	2	6	3.3	CNCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		16	9033	8	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
		9847194	9033	8	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
		CHEMBL313714	9033	8	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm980204e
		9844873	107835	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		CHEMBL294732	107835	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		10341917	174828	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	417	7	1	4	4.6	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1	10.1021/jm981133m
		CHEMBL432332	174828	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	417	7	1	4	4.6	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1	10.1021/jm981133m
		10766570	210159	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	464	8	1	5	4.2	CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1	10.1021/jm981133m
		CHEMBL65321	210159	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	464	8	1	5	4.2	CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1	10.1021/jm981133m
		10765655	121223	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	442	9	1	5	4.5	CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704558
		CHEMBL333341	121223	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	442	9	1	5	4.5	CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704558
		10341917	174828	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	417	7	1	4	4.6	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1	10.1021/jm980204e
		CHEMBL432332	174828	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	417	7	1	4	4.6	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1	10.1021/jm980204e
		10502669	63335	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	2	5	4.1	CC(C)(NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
		CHEMBL164046	63335	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	2	5	4.1	CC(C)(NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
		10719202	63331	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	471	8	1	6	3.1	CN(C)C(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		CHEMBL164035	63331	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	471	8	1	6	3.1	CN(C)C(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		10573843	126925	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	7	1	5	4.1	CC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		CHEMBL351346	126925	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	7	1	5	4.1	CC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		6426761	20729	1	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.8	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F	10.1021/jm9704560
		CHEMBL119668	20729	1	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.8	Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F	10.1021/jm9704560
		9844873	107835	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
		CHEMBL294732	107835	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	417	7	1	4	4.7	FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
		10647181	107643	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	449	8	1	4	5.3	Fc1ccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm981133m
		CHEMBL293614	107643	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	449	8	1	4	5.3	Fc1ccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm981133m
		10600212	109490	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	464	8	1	5	4.2	CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1F	10.1021/jm981133m
		CHEMBL304833	109490	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	464	8	1	5	4.2	CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1F	10.1021/jm981133m
		10600213	209888	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	464	8	1	5	4.2	CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm981133m
		CHEMBL64004	209888	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	464	8	1	5	4.2	CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm981133m
		9867902	61993	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique	ChEMBL	440	10	3	4	2.9	CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1	10.1021/jm9805687
		CHEMBL161780	61993	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique	ChEMBL	440	10	3	4	2.9	CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1	10.1021/jm9805687
		23374587	61346	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	267	4	1	4	2.0	c1cc2[nH]cc(CCN3CCC3)c2cc1-n1cnnc1	10.1021/jm9805687
		CHEMBL161045	61346	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	267	4	1	4	2.0	c1cc2[nH]cc(CCN3CCC3)c2cc1-n1cnnc1	10.1021/jm9805687
		9867902	61993	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	440	10	3	4	2.9	CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1	10.1021/jm9805687
		CHEMBL161780	61993	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	440	10	3	4	2.9	CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1	10.1021/jm9805687
		10789334	172120	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	442	8	1	5	3.7	CC(=O)N(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		CHEMBL423599	172120	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	442	8	1	5	3.7	CC(=O)N(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		10623614	127828	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	454	8	2	5	4.7	c1ccc2c(c1)CCC2NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL356808	127828	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	454	8	2	5	4.7	c1ccc2c(c1)CCC2NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10596566	63343	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	390	7	1	6	3.1	c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1	10.1021/jm980569z
		CHEMBL164111	63343	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	390	7	1	6	3.1	c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1	10.1021/jm980569z
		15521392	212761	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	444	6	1	5	3.7	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(CCc3cccc(F)c3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
		CHEMBL84712	212761	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	444	6	1	5	3.7	CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(CCc3cccc(F)c3)C[C@@H]21	10.1016/s0960-894x(99)00409-6
		44341707	16236	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	464	9	2	6	4.0	CN(CC1CCCCC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL111899	16236	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	464	9	2	6	4.0	CN(CC1CCCCC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10456869	16764	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	458	9	2	6	3.6	CN(Cc1ccccc1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL114877	16764	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	458	9	2	6	3.6	CN(Cc1ccccc1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10741826	45973	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	441	6	2	7	4.1	Oc1nc2ccccc2n1C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL146991	45973	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	441	6	2	7	4.1	Oc1nc2ccccc2n1C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		44341609	16667	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	472	9	2	6	3.9	Cc1ccccc1CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL114303	16667	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	472	9	2	6	3.9	Cc1ccccc1CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10646958	18179	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL118012	18179	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10646958	18179	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9704558
		CHEMBL118012	18179	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9704558
		10838153	20873	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL119785	20873	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		10838153	20873	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
		CHEMBL119785	20873	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
		9950538	211637	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand	ChEMBL	355	3	1	4	4.0	CN1CCC[C@@H]1Cc1c[nH]c2ccc(-n3cnc4cc(C#N)ccc43)cc12	10.1016/0960-894X(95)00417-R
		CHEMBL75642	211637	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand	ChEMBL	355	3	1	4	4.0	CN1CCC[C@@H]1Cc1c[nH]c2ccc(-n3cnc4cc(C#N)ccc43)cc12	10.1016/0960-894X(95)00417-R
		15516681	16974	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	422	9	2	6	2.9	CN(CC1CC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL115989	16974	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	422	9	2	6	2.9	CN(CC1CC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10502763	126920	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	430	9	3	6	2.9	OC[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
		CHEMBL351303	126920	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	430	9	3	6	2.9	OC[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
		10600678	125975	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	476	10	2	6	4.3	COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm9910021
		CHEMBL343217	125975	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	476	10	2	6	4.3	COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm9910021
		10551206	126036	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	442	9	2	5	4.7	C[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL343648	126036	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	442	9	2	5	4.7	C[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10645471	17814	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	1	5	3.5	c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL117633	17814	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	1	5	3.5	c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		10667886	62789	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	386	6	1	5	3.5	c1ccc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL162463	62789	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	386	6	1	5	3.5	c1ccc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		10645471	17814	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	414	8	1	5	3.5	c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
		CHEMBL117633	17814	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	414	8	1	5	3.5	c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704560
		44323355	213366	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	480	9	3	6	3.6	OC[C@H](NC1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm980204e
		CHEMBL88893	213366	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	480	9	3	6	3.6	OC[C@H](NC1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm980204e
		10572483	126665	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	390	8	2	6	3.0	c1coc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1	10.1021/jm9805687
		CHEMBL349041	126665	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	390	8	2	6	3.0	c1coc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1	10.1021/jm9805687
		10502988	44786	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	434	8	1	6	4.3	CN(Cc1ccsc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL146024	44786	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	434	8	1	6	4.3	CN(Cc1ccsc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10505525	45156	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	499	10	3	6	4.7	CC(=O)Nc1ccc([C@@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL146338	45156	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	499	10	3	6	4.7	CC(=O)Nc1ccc([C@@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10504600	46722	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	471	10	2	6	4.0	CN(C)C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL147818	46722	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	471	10	2	6	4.0	CN(C)C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10552663	127917	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	478	8	1	6	3.5	CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1	10.1021/jm9910021
		CHEMBL357634	127917	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	478	8	1	6	3.5	CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1	10.1021/jm9910021
		21460905	171680	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	298	7	2	5	2.3	c1cnc(NCCCNCC2CCc3ccccc3O2)nc1	10.1016/0960-894X(95)00473-7
		CHEMBL422243	171680	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	298	7	2	5	2.3	c1cnc(NCCCNCC2CCc3ccccc3O2)nc1	10.1016/0960-894X(95)00473-7
		10811007	59919	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
		CHEMBL159819	59919	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
		10811007	59919	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL159819	59919	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	400	8	2	5	3.4	c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		10812465	42305	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	9	2	5	4.2	c1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL143893	42305	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	9	2	5	4.2	c1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10719938	44734	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	492	9	1	6	3.7	CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1	10.1021/jm9910021
		CHEMBL145982	44734	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	492	9	1	6	3.7	CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1	10.1021/jm9910021
		10548444	63687	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	390	7	2	6	2.2	c1c[nH]c(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)n1	10.1021/jm980569z
		CHEMBL164413	63687	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	390	7	2	6	2.2	c1c[nH]c(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)n1	10.1021/jm980569z
		10600063	126789	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	460	9	1	4	4.2	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4C)cc23)C1	10.1021/jm9805687
		CHEMBL350153	126789	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	460	9	1	4	4.2	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4C)cc23)C1	10.1021/jm9805687
		10573904	128086	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	8	2	6	3.9	c1ccc(NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm9910021
		CHEMBL358072	128086	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	8	2	6	3.9	c1ccc(NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm9910021
		15516683	16844	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	438	8	2	6	3.5	CN(CC(C)(C)C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL115352	16844	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	438	8	2	6	3.5	CN(CC(C)(C)C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10814273	121129	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm9704560
		CHEMBL333089	121129	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	471	9	2	6	3.5	CC(=O)Nc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm9704560
		18975338	109394	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	416	7	2	6	2.5	OC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(Cc2ccccc2)CC1	10.1021/jm981133m
		CHEMBL304197	109394	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	416	7	2	6	2.5	OC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(Cc2ccccc2)CC1	10.1021/jm981133m
		10767140	210149	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	482	8	1	5	4.5	CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm981133m
		CHEMBL65215	210149	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	482	8	1	5	4.5	CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm981133m
		10813272	45093	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	446	8	2	5	4.6	CC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm9910021
		CHEMBL146285	45093	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	446	8	2	5	4.6	CC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1	10.1021/jm9910021
		10552243	46743	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	468	7	1	5	5.4	c1ccc(C2CCCCN2C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL147838	46743	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	468	7	1	5	5.4	c1ccc(C2CCCCN2C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		44458487	169852	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	353	9	3	2	4.8	CCCCCCCNC1CC=C(c2c[nH]c3ccc(C(N)=O)cc23)CC1	10.1016/0960-894X(94)00470-Z
		CHEMBL417650	169852	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	353	9	3	2	4.8	CCCCCCCNC1CC=C(c2c[nH]c3ccc(C(N)=O)cc23)CC1	10.1016/0960-894X(94)00470-Z
		18694196	213384	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	332	7	2	5	2.9	Clc1ccc(NCCCNCC2CCc3ccccc3O2)nn1	10.1016/0960-894X(95)00473-7
		CHEMBL89007	213384	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	332	7	2	5	2.9	Clc1ccc(NCCCNCC2CCc3ccccc3O2)nn1	10.1016/0960-894X(95)00473-7
		18694195	119091	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	298	7	2	5	2.3	c1ccc2c(c1)CCC(CNCCCNc1ccncn1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL329207	119091	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	298	7	2	5	2.3	c1ccc2c(c1)CCC(CNCCCNc1ccncn1)O2	10.1016/0960-894X(95)00473-7
		44323231	213244	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	298	7	2	5	2.3	c1ccc2c(c1)CCC(CNCCCNc1cnccn1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL88152	213244	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	298	7	2	5	2.3	c1ccc2c(c1)CCC(CNCCCNc1cnccn1)O2	10.1016/0960-894X(95)00473-7
		44323162	213346	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	330	8	3	5	2.1	c1ccc2c(c1)CCC(CNCCCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL88784	213346	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	330	8	3	5	2.1	c1ccc2c(c1)CCC(CNCCCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		10381677	113340	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	325	6	2	5	3.3	CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
		CHEMBL314213	113340	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	325	6	2	5	3.3	CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
		10718709	46058	19	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	458	6	2	5	3.8	COc1ccc(NC(=O)c2ccc(-c3ccc(C(N)=O)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm990397l
		CHEMBL147071	46058	19	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	458	6	2	5	3.8	COc1ccc(NC(=O)c2ccc(-c3ccc(C(N)=O)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm990397l
		2543	10479	68	None	-1	32	Human	7.0	pIC50	=	7	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00473-7
		5358	10479	68	None	-1	32	Human	7.0	pIC50	=	7	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00473-7
		54	10479	68	None	-1	32	Human	7.0	pIC50	=	7	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00473-7
		CHEMBL128	10479	68	None	-1	32	Human	7.0	pIC50	=	7	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00473-7
		DB00669	10479	68	None	-1	32	Human	7.0	pIC50	=	7	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00473-7
		18366015	85147	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	313	4	2	3	2.6	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		CHEMBL2110300	85147	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	313	4	2	3	2.6	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		18691565	96047	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	327	4	1	3	3.0	CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1	10.1021/jm000956k
		CHEMBL2368257	96047	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	327	4	1	3	3.0	CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1	10.1021/jm000956k
		10529106	105090	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	490	5	3	5	3.4	COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C(N)=O)cc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL274922	105090	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	490	5	3	5	3.4	COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C(N)=O)cc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		44341625	118094	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	501	10	4	7	3.3	CC(=O)Nc1ccc(CNCC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1016/s0960-894x(99)00614-9
		CHEMBL326723	118094	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	501	10	4	7	3.3	CC(=O)Nc1ccc(CNCC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1016/s0960-894x(99)00614-9
		10504095	172040	1	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	9	3	6	3.9	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](O)c1ccccc1	10.1021/jm9910021
		CHEMBL423022	172040	1	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	9	3	6	3.9	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](O)c1ccccc1	10.1021/jm9910021
		2393	10107	82	None	1	5	Human	8.0	pIC50	=	8.0	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9704558
		5078	10107	82	None	1	5	Human	8.0	pIC50	=	8.0	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9704558
		51	10107	82	None	1	5	Human	8.0	pIC50	=	8.0	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9704558
		CHEMBL905	10107	82	None	1	5	Human	8.0	pIC50	=	8.0	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9704558
		DB00953	10107	82	None	1	5	Human	8.0	pIC50	=	8.0	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9704558
		11722647	212201	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand	ChEMBL	305	4	1	4	3.0	CN(C)CCc1c[nH]c2ccc(-n3cnc4cccnc43)cc12	10.1016/0960-894X(95)00417-R
		CHEMBL80189	212201	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand	ChEMBL	305	4	1	4	3.0	CN(C)CCc1c[nH]c2ccc(-n3cnc4cccnc43)cc12	10.1016/0960-894X(95)00417-R
		10353268	104546	1	None	-	4	Human	7.0	pIC50	=	7.0	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	216	2	2	2	2.0	NCCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm00098a005
		CHEMBL27173	104546	1	None	-	4	Human	7.0	pIC50	=	7.0	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	216	2	2	2	2.0	NCCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm00098a005
		44362284	42131	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	322	8	1	2	4.6	CCN(CC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		CHEMBL143723	42131	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	322	8	1	2	4.6	CCN(CC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		44362284	42131	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells	ChEMBL	322	8	1	2	4.6	CCN(CC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		CHEMBL143723	42131	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells	ChEMBL	322	8	1	2	4.6	CCN(CC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		10575878	42302	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	9	3	6	3.9	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](O)c1ccccc1	10.1021/jm9910021
		CHEMBL143890	42302	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	9	3	6	3.9	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](O)c1ccccc1	10.1021/jm9910021
		10718668	126697	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	457	9	3	6	3.4	CC(=O)Nc1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL349390	126697	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	457	9	3	6	3.4	CC(=O)Nc1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		10592083	42375	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	324	5	2	5	2.1	NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL143951	42375	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	324	5	2	5	2.1	NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10696275	44783	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	485	10	3	6	3.9	CC(=O)Nc1ccc(CCNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL146023	44783	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	485	10	3	6	3.9	CC(=O)Nc1ccc(CCNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		44323506	213801	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F	10.1021/jm981133m
		CHEMBL91534	213801	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F	10.1021/jm981133m
		44323147	174671	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	316	7	3	5	1.7	c1ccc2c(c1)CCC(CNCCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL431211	174671	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	316	7	3	5	1.7	c1ccc2c(c1)CCC(CNCCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		44346844	23109	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	244	3	1	2	2.6	CN(C)CCc1c[nH]c2cc3c(cc12)OCCC3	10.1021/jm00098a005
		CHEMBL122860	23109	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	244	3	1	2	2.6	CN(C)CCc1c[nH]c2cc3c(cc12)OCCC3	10.1021/jm00098a005
		44323157	213724	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	288	6	3	5	0.9	c1ccc2c(c1)CC(CNCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL91154	213724	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	288	6	3	5	0.9	c1ccc2c(c1)CC(CNCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		10694686	213914	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)[C@@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F	10.1021/jm980204e
		CHEMBL92207	213914	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)[C@@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F	10.1021/jm980204e
		67650716	86303	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	514	8	1	5	5.2	CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F	10.1021/jm981133m
		CHEMBL2114039	86303	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	514	8	1	5	5.2	CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F	10.1021/jm981133m
		71461714	86423	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	500	8	2	5	4.9	F[C@@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F	10.1021/jm981133m
		CHEMBL2115111	86423	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	500	8	2	5	4.9	F[C@@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F	10.1021/jm981133m
		15233110	11088	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HTInhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT	ChEMBL	394	4	1	5	3.4	OC1(c2ccc3c(c2)OCO3)CCC(N2CCN(Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(02)00879-x
		CHEMBL100875	11088	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HTInhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT	ChEMBL	394	4	1	5	3.4	OC1(c2ccc3c(c2)OCO3)CCC(N2CCN(Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(02)00879-x
		10614906	117282	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	310	4	1	5	1.5	CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		CHEMBL324931	117282	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	310	4	1	5	1.5	CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		10381889	113846	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity against 5-HT1D receptorBinding affinity against 5-HT1D receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(02)00796-5
		CHEMBL315772	113846	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity against 5-HT1D receptorBinding affinity against 5-HT1D receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(02)00796-5
		10381889	113846	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL315772	113846	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(01)00721-1
		10693207	44755	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	8	2	6	3.3	c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm9910021
		CHEMBL145997	44755	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	8	2	6	3.3	c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1	10.1021/jm9910021
		10588665	96044	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	278	3	2	2	4.2	N[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1	10.1021/jm000956k
		CHEMBL2368254	96044	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	278	3	2	2	4.2	N[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1	10.1021/jm000956k
		10539089	58732	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	257	3	2	2	2.1	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(N)=O)cc32)C1	10.1021/jm000956k
		CHEMBL158638	58732	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	257	3	2	2	2.1	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(N)=O)cc32)C1	10.1021/jm000956k
		10614906	117282	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	310	4	1	5	1.5	CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
		CHEMBL324931	117282	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	310	4	1	5	1.5	CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
		12	8335	17	None	-12	7	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor in calfInhibitory activity against 5-hydroxytryptamine 1D receptor in calf	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
		6918513	8335	17	None	-12	7	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor in calfInhibitory activity against 5-hydroxytryptamine 1D receptor in calf	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
		CHEMBL267615	8335	17	None	-12	7	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor in calfInhibitory activity against 5-hydroxytryptamine 1D receptor in calf	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
		10617665	59536	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	347	5	2	2	3.9	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(=O)NCc4ccccc4)cc32)C1	10.1021/jm000956k
		CHEMBL159470	59536	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	347	5	2	2	3.9	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(=O)NCc4ccccc4)cc32)C1	10.1021/jm000956k
		10714071	96052	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	368	5	2	3	2.8	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)NC(C)(C)C4=O)cc32)C1	10.1021/jm000956k
		CHEMBL2368262	96052	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	368	5	2	3	2.8	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)NC(C)(C)C4=O)cc32)C1	10.1021/jm000956k
		10768329	47022	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	521	11	3	7	3.0	CS(=O)(=O)NC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL148071	47022	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	521	11	3	7	3.0	CS(=O)(=O)NC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		5492087	212789	4	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	337	4	2	5	3.6	CN1CCC(c2c[nH]c3ccc(Nc4ncccc4[N+](=O)[O-])cc23)C1	10.1021/jm00042a003
		CHEMBL84942	212789	4	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	337	4	2	5	3.6	CN1CCC(c2c[nH]c3ccc(Nc4ncccc4[N+](=O)[O-])cc23)C1	10.1021/jm00042a003
		10695596	109570	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	468	8	1	5	3.9	Fc1cccc(CCN2CCN(CC(F)(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		CHEMBL305301	109570	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	468	8	1	5	3.9	Fc1cccc(CCN2CCN(CC(F)(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		44322823	213259	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	302	6	3	5	1.3	c1ccc2c(c1)CC[C@@H](CNCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL88212	213259	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	302	6	3	5	1.3	c1ccc2c(c1)CC[C@@H](CNCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		18366015	85147	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	313	4	2	3	2.6	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		CHEMBL2110300	85147	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	313	4	2	3	2.6	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		44272419	73810	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate	ChEMBL	232	4	1	3	1.6	CN(C)CCc1coc2ccc(C(N)=O)cc12	10.1016/S0960-894X(01)80331-0
		CHEMBL18710	73810	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate	ChEMBL	232	4	1	3	1.6	CN(C)CCc1coc2ccc(C(N)=O)cc12	10.1016/S0960-894X(01)80331-0
		44322916	213697	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	330	6	3	5	1.2	O=C1CCCN=C(NCCCNCC2CCc3ccccc3O2)N1	10.1016/0960-894X(95)00473-7
		CHEMBL90981	213697	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	330	6	3	5	1.2	O=C1CCCN=C(NCCCNCC2CCc3ccccc3O2)N1	10.1016/0960-894X(95)00473-7
		10502495	60489	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	425	6	3	4	3.4	COc1ccc(NC(=O)NCCc2c[nH]c3ccc(F)cc23)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL16035	60489	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	425	6	3	4	3.4	COc1ccc(NC(=O)NCCc2c[nH]c3ccc(F)cc23)cc1N1CCN(C)CC1	10.1021/jm9811054
		18366015	85147	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	313	4	2	3	2.6	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		CHEMBL2110300	85147	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	313	4	2	3	2.6	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		10689227	62591	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	350	8	2	5	2.4	C=CCNC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		CHEMBL162296	62591	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	350	8	2	5	2.4	C=CCNC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		10768115	126503	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	513	9	2	6	4.1	CC(=O)Nc1ccc(C(=O)N(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL347570	126503	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	513	9	2	6	4.1	CC(=O)Nc1ccc(C(=O)N(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10691904	42394	0	None	-3	4	Human	6.8	pIC50	=	6.8	Binding	Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.	ChEMBL	392	9	1	4	4.1	CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		CHEMBL143967	42394	0	None	-3	4	Human	6.8	pIC50	=	6.8	Binding	Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.	ChEMBL	392	9	1	4	4.1	CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		10764284	62208	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	7	1	5	3.0	O=C1CN(Cc2ccccc2)CCN1CCCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm980569z
		CHEMBL161969	62208	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	7	1	5	3.0	O=C1CN(Cc2ccccc2)CCN1CCCc1c[nH]c2ccc(-n3cnnc3)cc12	10.1021/jm980569z
		10550488	42429	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL144002	42429	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	2	5	4.5	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10625408	46494	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	506	9	1	7	3.7	CN(Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL147555	46494	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	506	9	1	7	3.7	CN(Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10766277	47311	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	457	7	2	5	4.3	CN(C(=O)Nc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL148325	47311	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	457	7	2	5	4.3	CN(C(=O)Nc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10576874	48750	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	485	9	2	6	4.2	CC(=O)Nc1ccc(CN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL149488	48750	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	485	9	2	6	4.2	CC(=O)Nc1ccc(CN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10805623	106028	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	320	1	1	4	2.9	FC(F)(F)c1ccc2c(c1)nc(N1CCNCC1)c1cccn12	10.1021/jm00170a007
		CHEMBL28178	106028	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	320	1	1	4	2.9	FC(F)(F)c1ccc2c(c1)nc(N1CCNCC1)c1cccn12	10.1021/jm00170a007
		10805740	96049	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	321	5	2	3	2.0	CNS(=O)(=O)Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1	10.1021/jm000956k
		CHEMBL2368259	96049	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	321	5	2	3	2.0	CNS(=O)(=O)Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1	10.1021/jm000956k
		10643940	96051	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	387	5	1	3	3.8	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)c5ccccc5C4=O)cc32)C1	10.1021/jm000956k
		CHEMBL2368261	96051	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	387	5	1	3	3.8	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)c5ccccc5C4=O)cc32)C1	10.1021/jm000956k
		10812592	107661	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	431	8	1	4	5.1	FC1(CCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		CHEMBL293678	107661	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	431	8	1	4	5.1	FC1(CCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		10718714	44916	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	10	3	6	3.3	OC[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL146131	44916	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	10	3	6	3.3	OC[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10693206	61936	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	9	1	5	4.2	c1ccc(COC[C@@H]2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL161735	61936	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	9	1	5	4.2	c1ccc(COC[C@@H]2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		11796806	109494	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL304857	109494	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		71459969	86305	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F	10.1021/jm981133m
		CHEMBL2114040	86305	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F	10.1021/jm981133m
		11796806	109494	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		CHEMBL304857	109494	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		11796806	109494	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704558
		CHEMBL304857	109494	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704558
		11796806	109494	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
		CHEMBL304857	109494	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	428	8	1	5	4.3	CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
		44323506	213801	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F	10.1021/jm980204e
		CHEMBL91534	213801	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F	10.1021/jm980204e
		10739818	117920	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	401	8	1	5	3.8	c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
		CHEMBL326371	117920	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	401	8	1	5	3.8	c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
		44214559	63272	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	443	8	2	6	2.5	NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		CHEMBL163462	63272	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	443	8	2	6	2.5	NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		10739818	117920	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	1	5	3.8	c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL326371	117920	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	1	5	3.8	c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		11796807	172322	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	9	2	5	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1)c1ccccc1	10.1021/jm9805687
		CHEMBL424154	172322	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	9	2	5	4.0	C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1)c1ccccc1	10.1021/jm9805687
		9890331	63141	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	457	8	2	6	3.5	CC(=O)Nc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL163127	63141	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	457	8	2	6	3.5	CC(=O)Nc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		117	7141	19	None	1	2	Human	8.6	pIC50	=	8.6	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	10.1016/0960-894X(95)00473-7
		120	7141	19	None	1	2	Human	8.6	pIC50	=	8.6	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	10.1016/0960-894X(95)00473-7
		66004	7141	19	None	1	2	Human	8.6	pIC50	=	8.6	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	10.1016/0960-894X(95)00473-7
		CHEMBL88240	7141	19	None	1	2	Human	8.6	pIC50	=	8.6	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	10.1016/0960-894X(95)00473-7
		10740531	126644	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	9	2	5	3.4	c1ccc(CCNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL348815	126644	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	9	2	5	3.4	c1ccc(CCNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		10835928	127849	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	420	9	1	5	4.4	CC(C)=CCCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL357007	127849	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	420	9	1	5	4.4	CC(C)=CCCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		44458229	105995	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	648	17	6	4	7.7	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		CHEMBL281575	105995	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	648	17	6	4	7.7	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		2869	10924	89	None	-2	7	Human	8.6	pIC50	=	8.6	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm000956k
		60	10924	89	None	-2	7	Human	8.6	pIC50	=	8.6	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm000956k
		60857	10924	89	None	-2	7	Human	8.6	pIC50	=	8.6	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm000956k
		CHEMBL1185	10924	89	None	-2	7	Human	8.6	pIC50	=	8.6	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm000956k
		DB00315	10924	89	None	-2	7	Human	8.6	pIC50	=	8.6	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm000956k
		2543	10479	68	None	-1	32	Human	8.5	pIC50	=	8.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm000956k
		5358	10479	68	None	-1	32	Human	8.5	pIC50	=	8.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm000956k
		54	10479	68	None	-1	32	Human	8.5	pIC50	=	8.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm000956k
		CHEMBL128	10479	68	None	-1	32	Human	8.5	pIC50	=	8.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm000956k
		DB00669	10479	68	None	-1	32	Human	8.5	pIC50	=	8.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm000956k
		10596387	175238	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL435060	175238	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		10571716	47268	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	378	8	1	5	3.3	C=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL148286	47268	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	378	8	1	5	3.3	C=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		44458045	105453	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	564	11	6	4	5.4	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		CHEMBL277452	105453	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	564	11	6	4	5.4	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		44344504	119609	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	295	4	1	4	2.8	c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1	10.1021/jm9704558
		CHEMBL330803	119609	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	295	4	1	4	2.8	c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1	10.1021/jm9704558
		10764757	50801	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	423	6	4	5	3.0	COc1ccc(NC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL15139	50801	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	423	6	4	5	3.0	COc1ccc(NC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1N1CCN(C)CC1	10.1021/jm9811054
		10696986	59737	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	508	7	3	5	4.1	COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL15965	59737	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	508	7	3	5	4.1	COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		10096048	105631	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	465	4	2	4	4.5	COc1ccc(NC(=O)N2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL278917	105631	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	465	4	2	4	4.5	COc1ccc(NC(=O)N2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		10814424	105780	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	475	6	2	4	4.8	COc1ccc(NC(=O)N2CCC(CCc3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL280000	105780	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	475	6	2	4	4.8	COc1ccc(NC(=O)N2CCC(CCc3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		44344504	119609	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	295	4	1	4	2.8	c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1	10.1021/jm9805687
		CHEMBL330803	119609	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	295	4	1	4	2.8	c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1	10.1021/jm9805687
		10852406	59614	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	309	4	2	3	3.0	Cc1nc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n[nH]1	10.1021/jm000956k
		CHEMBL159536	59614	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	309	4	2	3	3.0	Cc1nc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n[nH]1	10.1021/jm000956k
		44341783	16871	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	454	7	3	7	3.0	CC(C)(C)OC(=O)NCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL115496	16871	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	454	7	3	7	3.0	CC(C)(C)OC(=O)NCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10618751	41964	0	None	1	4	Human	7.7	pIC50	=	7.7	Binding	Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.	ChEMBL	364	7	1	4	3.3	CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		CHEMBL143510	41964	0	None	1	4	Human	7.7	pIC50	=	7.7	Binding	Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.	ChEMBL	364	7	1	4	3.3	CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		10759465	171674	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	338	6	1	5	2.3	CN1CCN(CCCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		CHEMBL422191	171674	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	338	6	1	5	2.3	CN1CCN(CCCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		10691928	46698	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	392	8	1	5	3.5	CN(CC1CC1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL147786	46698	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	392	8	1	5	3.5	CN(CC1CC1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		15011385	168331	4	None	-	4	Human	6.7	pIC50	=	6.7	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	244	3	1	2	2.6	CN(C)CCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm00098a005
		CHEMBL412876	168331	4	None	-	4	Human	6.7	pIC50	=	6.7	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	244	3	1	2	2.6	CN(C)CCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm00098a005
		11	7970	19	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	215	1	3	2	1.2	O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1	10.1021/jm00170a007
		124007	7970	19	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	215	1	3	2	1.2	O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1	10.1021/jm00170a007
		CHEMBL304008	7970	19	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	215	1	3	2	1.2	O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1	10.1021/jm00170a007
		9930155	170811	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
		CHEMBL420874	170811	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
		10837591	125539	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	458	10	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL341854	125539	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	458	10	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		9824884	58633	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	447	4	2	4	4.3	COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL15855	58633	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	447	4	2	4	4.3	COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		10412189	84028	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	465	4	2	4	4.5	COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL2079627	84028	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	465	4	2	4	4.5	COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		10647243	105725	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	451	4	2	4	4.1	COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)C2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL279646	105725	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	451	4	2	4	4.1	COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)C2)cc1N1CCN(C)CC1	10.1021/jm9811054
		9881324	35145	3	None	-	0	Guinea pig	7.6	pIC50	=	7.6	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	244	3	1	2	2.8	COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1021/jm00101a032
		CHEMBL137485	35145	3	None	-	0	Guinea pig	7.6	pIC50	=	7.6	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	244	3	1	2	2.8	COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1021/jm00101a032
		10733696	120105	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	309	5	1	4	3.2	c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1	10.1021/jm9704558
		CHEMBL331612	120105	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	309	5	1	4	3.2	c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1	10.1021/jm9704558
		10835665	45665	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	8	2	6	3.3	c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1	10.1021/jm9910021
		CHEMBL146729	45665	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	8	2	6	3.3	c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1	10.1021/jm9910021
		10733696	120105	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	309	5	1	4	3.2	c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1	10.1021/jm980569z
		CHEMBL331612	120105	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	309	5	1	4	3.2	c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1	10.1021/jm980569z
		2543	10479	68	None	-1	32	Human	5.6	pIC50	=	5.6	Binding	Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
		5358	10479	68	None	-1	32	Human	5.6	pIC50	=	5.6	Binding	Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
		54	10479	68	None	-1	32	Human	5.6	pIC50	=	5.6	Binding	Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
		CHEMBL128	10479	68	None	-1	32	Human	5.6	pIC50	=	5.6	Binding	Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
		DB00669	10479	68	None	-1	32	Human	5.6	pIC50	=	5.6	Binding	Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
		10782381	96048	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	326	4	2	3	2.0	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)CNC4=O)cc32)C1	10.1021/jm000956k
		CHEMBL2368258	96048	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	326	4	2	3	2.0	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)CNC4=O)cc32)C1	10.1021/jm000956k
		59022	127868	16	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells	ChEMBL	294	6	1	2	3.9	CN(C)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		CHEMBL357130	127868	16	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells	ChEMBL	294	6	1	2	3.9	CN(C)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		44322821	213452	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	304	6	3	6	0.7	c1ccc2c(c1)OCC(CNCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL89448	213452	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	304	6	3	6	0.7	c1ccc2c(c1)OCC(CNCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		10519108	59718	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	311	5	2	5	1.6	OC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		CHEMBL159627	59718	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	311	5	2	5	1.6	OC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		1524	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9704558
		197	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9704558
		3822	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9704558
		88	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9704558
		CHEMBL51	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9704558
		DB12465	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9704558
		44458486	105591	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	550	10	6	4	5.0	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		CHEMBL278610	105591	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	550	10	6	4	5.0	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		1524	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9910021
		197	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9910021
		3822	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9910021
		88	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9910021
		CHEMBL51	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9910021
		DB12465	8962	96	None	-257	51	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm9910021
		10592324	110239	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	327	5	2	3	2.7	CN(C)[C@H]1C[C@H](Cc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1	10.1021/jm000956k
		CHEMBL3084967	110239	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	327	5	2	3	2.7	CN(C)[C@H]1C[C@H](Cc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1	10.1021/jm000956k
		10694895	109222	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	451	8	1	5	4.7	FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(COc2ccccc2)CC1	10.1021/jm981133m
		CHEMBL303997	109222	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	451	8	1	5	4.7	FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(COc2ccccc2)CC1	10.1021/jm981133m
		10838622	44938	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	485	9	3	6	4.5	CC(=O)Nc1ccc([C@@H](C)NC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL146150	44938	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	485	9	3	6	4.5	CC(=O)Nc1ccc([C@@H](C)NC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		5	6927	72	None	-	53	Guinea pig	8.5	pIC50	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
		5202	6927	72	None	-	53	Guinea pig	8.5	pIC50	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
		CHEMBL39	6927	72	None	-	53	Guinea pig	8.5	pIC50	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
		DB08839	6927	72	None	-	53	Guinea pig	8.5	pIC50	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
		10766318	44547	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	10	2	6	4.1	COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL145815	44547	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	10	2	6	4.1	COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		5	6927	72	None	-8	53	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
		5202	6927	72	None	-8	53	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
		CHEMBL39	6927	72	None	-8	53	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
		DB08839	6927	72	None	-8	53	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
		10719203	45153	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	471	9	3	6	3.9	CC(=O)Nc1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL146335	45153	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	471	9	3	6	3.9	CC(=O)Nc1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		9846928	46453	15	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	457	6	3	5	4.0	COc1ccc(NC(=O)c2ccc(-c3ccc(C(=N)N)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm990397l
		CHEMBL147503	46453	15	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	457	6	3	5	4.0	COc1ccc(NC(=O)c2ccc(-c3ccc(C(=N)N)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm990397l
		5	6927	72	None	-6	53	Human	8.5	pIC50	=	8.5	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandInhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00170a007
		5202	6927	72	None	-6	53	Human	8.5	pIC50	=	8.5	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandInhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00170a007
		CHEMBL39	6927	72	None	-6	53	Human	8.5	pIC50	=	8.5	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandInhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00170a007
		DB08839	6927	72	None	-6	53	Human	8.5	pIC50	=	8.5	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandInhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00170a007
		5	6927	72	None	-6	53	Human	8.5	pIC50	=	8.5	Binding	Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
		5202	6927	72	None	-6	53	Human	8.5	pIC50	=	8.5	Binding	Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
		CHEMBL39	6927	72	None	-6	53	Human	8.5	pIC50	=	8.5	Binding	Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
		DB08839	6927	72	None	-6	53	Human	8.5	pIC50	=	8.5	Binding	Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
		5487088	212626	38	None	-	0	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	351	5	2	5	3.9	CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
		CHEMBL83597	212626	38	None	-	0	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	351	5	2	5	3.9	CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
		10468938	17016	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm980569z
		CHEMBL116092	17016	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm980569z
		10468938	17016	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9805687
		CHEMBL116092	17016	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9805687
		10468938	17016	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9910021
		CHEMBL116092	17016	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9910021
		9817881	213331	2	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	302	6	3	5	1.3	c1ccc2c(c1)CCC(CNCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL88676	213331	2	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	302	6	3	5	1.3	c1ccc2c(c1)CCC(CNCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		44323074	213600	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	319	8	4	4	1.2	CC(C)/N=C(\N)NNCCCNCC1CCc2ccccc2O1	10.1016/0960-894X(95)00473-7
		CHEMBL90443	213600	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	319	8	4	4	1.2	CC(C)/N=C(\N)NNCCCNCC1CCc2ccccc2O1	10.1016/0960-894X(95)00473-7
		44322934	213814	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	332	7	3	6	1.3	COc1ccc2c(c1)OC(CNCCCNC1=NCCCN1)CC2	10.1016/0960-894X(95)00473-7
		CHEMBL91596	213814	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	332	7	3	6	1.3	COc1ccc2c(c1)OC(CNCCCNC1=NCCCN1)CC2	10.1016/0960-894X(95)00473-7
		44341637	16373	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	445	9	3	7	2.7	OC1(CNCc2ccccn2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL112558	16373	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	445	9	3	7	2.7	OC1(CNCc2ccccn2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		11796081	61511	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	9	2	5	3.5	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(Cn5cncn5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL161192	61511	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	9	2	5	3.5	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(Cn5cncn5)cc34)C2)cc1	10.1021/jm9805687
		44318323	111134	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	424	7	1	5	4.2	CN1C[C@@H](CN(C#N)Cc2ccccc2)C[C@@H]1Cc1c[nH]c2ccc(-n3ccnc3)cc12	10.1016/s0960-894x(99)00409-6
		CHEMBL310061	111134	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)	ChEMBL	424	7	1	5	4.2	CN1C[C@@H](CN(C#N)Cc2ccccc2)C[C@@H]1Cc1c[nH]c2ccc(-n3ccnc3)cc12	10.1016/s0960-894x(99)00409-6
		44457909	69359	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	578	12	6	4	5.8	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		CHEMBL17828	69359	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	578	12	6	4	5.8	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		1809	6922	32	None	-10	37	Human	8.5	pIC50	=	8.5	Binding	In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/S0960-894X(01)80331-0
		4	6922	32	None	-10	37	Human	8.5	pIC50	=	8.5	Binding	In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/S0960-894X(01)80331-0
		CHEMBL18840	6922	32	None	-10	37	Human	8.5	pIC50	=	8.5	Binding	In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/S0960-894X(01)80331-0
		10468938	17016	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9704558
		CHEMBL116092	17016	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9704558
		10766320	45067	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	458	10	3	6	3.7	OC[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL146265	45067	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	458	10	3	6	3.7	OC[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10468938	17016	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9704560
		CHEMBL116092	17016	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	281	4	1	4	2.4	c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1	10.1021/jm9704560
		11797562	44917	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	444	9	3	6	3.5	OC[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL146132	44917	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	444	9	3	6	3.5	OC[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10575553	209818	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		CHEMBL63432	209818	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		10644749	126762	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	2	6	2.8	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)nc1	10.1021/jm9805687
		CHEMBL349893	126762	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	2	6	2.8	c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)nc1	10.1021/jm9805687
		18691541	85146	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	285	3	3	3	2.0	N[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		CHEMBL2110299	85146	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	285	3	3	3	2.0	N[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		10575553	209818	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980204e
		CHEMBL63432	209818	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980204e
		10525100	126299	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	2	6	2.8	c1cncc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1	10.1021/jm9805687
		CHEMBL345657	126299	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	2	6	2.8	c1cncc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1	10.1021/jm9805687
		18694165	213717	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	301	6	2	4	2.5	c1ccc2c(c1)CCC(CNCCCNC1=NCCCC1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL91123	213717	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	301	6	2	4	2.5	c1ccc2c(c1)CCC(CNCCCNC1=NCCCC1)O2	10.1016/0960-894X(95)00473-7
		10812693	109530	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	433	8	1	5	4.3	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1	10.1021/jm981133m
		CHEMBL305062	109530	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	433	8	1	5	4.3	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1	10.1021/jm981133m
		10412190	59692	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	465	4	2	4	4.5	COc1ccc(NC(=O)N2CCC(c3c[nH]c4cccc(F)c34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL15961	59692	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	465	4	2	4	4.5	COc1ccc(NC(=O)N2CCC(c3c[nH]c4cccc(F)c34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		44318454	212788	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL84931	212788	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1	10.1016/s0960-894x(01)00721-1
		10665840	96050	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	354	4	2	3	2.8	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)NC(C)(C)C4=O)cc32)C1	10.1021/jm000956k
		CHEMBL2368260	96050	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	354	4	2	3	2.8	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)NC(C)(C)C4=O)cc32)C1	10.1021/jm000956k
		10614907	104961	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	310	5	2	5	1.6	c1cc2[nH]cc(CCCN3CCNCC3)c2cc1-n1cnnc1	10.1021/jm980569z
		CHEMBL274001	104961	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	310	5	2	5	1.6	c1cc2[nH]cc(CCCN3CCNCC3)c2cc1-n1cnnc1	10.1021/jm980569z
		21460878	112912	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	284	6	2	5	1.9	c1cnc(NCCNCC2CCc3ccccc3O2)nc1	10.1016/0960-894X(95)00473-7
		CHEMBL313490	112912	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	284	6	2	5	1.9	c1cnc(NCCNCC2CCc3ccccc3O2)nc1	10.1016/0960-894X(95)00473-7
		9949172	17645	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	324	5	1	5	1.9	CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		CHEMBL117249	17645	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	324	5	1	5	1.9	CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980569z
		10546537	126804	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	361	6	2	2	3.8	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(=O)NCc4ccccc4)cc32)C1	10.1021/jm000956k
		CHEMBL350277	126804	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	361	6	2	2	3.8	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(=O)NCc4ccccc4)cc32)C1	10.1021/jm000956k
		109	7689	31	None	1	7	Human	7.5	pIC50	=	7.5	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	10.1021/jm00170a007
		2689	7689	31	None	1	7	Human	7.5	pIC50	=	7.5	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	10.1021/jm00170a007
		CHEMBL27403	7689	31	None	1	7	Human	7.5	pIC50	=	7.5	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	10.1021/jm00170a007
		10549785	45859	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	8	2	6	3.3	c1cncc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm9910021
		CHEMBL146891	45859	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	8	2	6	3.3	c1cncc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm9910021
		9949172	17645	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	324	5	1	5	1.9	CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
		CHEMBL117249	17645	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	324	5	1	5	1.9	CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9704560
		10624003	210442	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	464	8	1	5	4.5	CN(Cc1ccccc1)C1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		CHEMBL67367	210442	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	464	8	1	5	4.5	CN(Cc1ccccc1)C1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		10530035	58406	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	522	8	2	5	4.2	COc1ccc(NC(=O)N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL15837	58406	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	522	8	2	5	4.2	COc1ccc(NC(=O)N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		10621020	117162	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	400	7	1	5	3.5	CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		CHEMBL324287	117162	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	400	7	1	5	3.5	CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		44364110	42309	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	456	7	3	6	3.4	O[C@H]1Cc2ccccc2C1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL143894	42309	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	456	7	3	6	3.4	O[C@H]1Cc2ccccc2C1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10323598	45673	21	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	497	6	1	7	5.0	COc1ccc(NC(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm990397l
		CHEMBL146735	45673	21	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	497	6	1	7	5.0	COc1ccc(NC(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm990397l
		10621020	117162	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	400	7	1	5	3.5	CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9704558
		CHEMBL324287	117162	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	400	7	1	5	3.5	CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9704558
		135	9310	43	None	-43	56	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		1796	9310	43	None	-43	56	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		4184	9310	43	None	-43	56	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		CHEMBL6437	9310	43	None	-43	56	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		DB06148	9310	43	None	-43	56	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		108029	10187	57	None	-19	13	Human	7.4	pIC50	=	7.4	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	10.1021/jm00170a007
		23	10187	57	None	-19	13	Human	7.4	pIC50	=	7.4	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	10.1021/jm00170a007
		CHEMBL18785	10187	57	None	-19	13	Human	7.4	pIC50	=	7.4	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	10.1021/jm00170a007
		44323156	113696	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	300	6	3	4	1.7	c1ccc2c(c1)CCC(CNCCCNC1=NCCCN1)C2	10.1016/0960-894X(95)00473-7
		CHEMBL314738	113696	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	300	6	3	4	1.7	c1ccc2c(c1)CCC(CNCCCNC1=NCCCN1)C2	10.1016/0960-894X(95)00473-7
		2543	10479	68	None	-1	32	Human	7.4	pIC50	=	7.4	Binding	Binding activity radioligand.Binding activity radioligand.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00010a025
		5358	10479	68	None	-1	32	Human	7.4	pIC50	=	7.4	Binding	Binding activity radioligand.Binding activity radioligand.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00010a025
		54	10479	68	None	-1	32	Human	7.4	pIC50	=	7.4	Binding	Binding activity radioligand.Binding activity radioligand.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00010a025
		CHEMBL128	10479	68	None	-1	32	Human	7.4	pIC50	=	7.4	Binding	Binding activity radioligand.Binding activity radioligand.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00010a025
		DB00669	10479	68	None	-1	32	Human	7.4	pIC50	=	7.4	Binding	Binding activity radioligand.Binding activity radioligand.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00010a025
		11626724	117253	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	458	9	3	6	3.6	Cc1ccccc1CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL324751	117253	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	458	9	3	6	3.6	Cc1ccccc1CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10646959	46889	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL147961	46889	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	444	9	3	6	3.5	OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10836301	59738	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	9	1	5	4.1	CN(Cc1ccccc1)C[C@@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		CHEMBL159650	59738	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	9	1	5	4.1	CN(Cc1ccccc1)C[C@@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		10788620	46821	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	427	8	2	4	5.1	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL147907	46821	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	427	8	2	4	5.1	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10767244	46863	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	485	10	3	6	4.1	CC(=O)Nc1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL147940	46863	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	485	10	3	6	4.1	CC(=O)Nc1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10504096	125713	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	9	2	6	3.8	CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](CO)c1ccccc1	10.1021/jm9910021
		CHEMBL342330	125713	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	9	2	6	3.8	CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](CO)c1ccccc1	10.1021/jm9910021
		10717709	172061	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	434	8	1	6	4.3	CN(Cc1cccs1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL423212	172061	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	434	8	1	6	4.3	CN(Cc1cccs1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10646873	45222	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	442	9	2	5	4.7	C[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL146391	45222	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	442	9	2	5	4.7	C[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		44341657	119834	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	408	9	3	6	2.5	OC1(CNCC2CC2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL331143	119834	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	408	9	3	6	2.5	OC1(CNCC2CC2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		10551857	172151	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	9	2	6	3.8	CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1	10.1021/jm9910021
		CHEMBL423749	172151	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	9	2	6	3.8	CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1	10.1021/jm9910021
		11795525	127894	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	404	8	2	6	3.5	c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1	10.1021/jm9910021
		CHEMBL357408	127894	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	404	8	2	6	3.5	c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1	10.1021/jm9910021
		10597901	17425	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	2	5	3.9	c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL117046	17425	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	8	2	5	3.9	c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10838684	125918	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	487	10	3	7	3.6	NC(=O)OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL342805	125918	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	487	10	3	7	3.6	NC(=O)OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10551525	107446	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1ccccc1CCN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		CHEMBL292262	107446	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1ccccc1CCN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		10597901	17425	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	414	8	2	5	3.9	c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704558
		CHEMBL117046	17425	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	414	8	2	5	3.9	c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9704558
		10811801	126922	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	8	1	6	2.9	c1cncc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
		CHEMBL351311	126922	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	415	8	1	6	2.9	c1cncc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm980569z
		10670211	126998	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	9	1	5	3.9	c1ccc(CCCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL352123	126998	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	9	1	5	3.9	c1ccc(CCCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		10838188	174396	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	472	4	2	5	4.2	COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C#N)cc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL430122	174396	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	472	4	2	5	4.2	COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C#N)cc34)CC2)cc1N1CCN(C)CC1	10.1021/jm9811054
		10624680	128796	17	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	483	5	2	7	4.7	Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1	10.1021/jm990397l
		CHEMBL359447	128796	17	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	483	5	2	7	4.7	Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1	10.1021/jm990397l
		4223	10764	94	None	-	3	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
		6918314	10764	94	None	-	3	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
		7427	10764	94	None	-	3	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
		CHEMBL439849	10764	94	None	-	3	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
		DB06684	10764	94	None	-	3	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
		44272400	74731	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate	ChEMBL	204	3	2	3	1.0	NCCc1coc2ccc(C(N)=O)cc12	10.1016/S0960-894X(01)80331-0
		CHEMBL19114	74731	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate	ChEMBL	204	3	2	3	1.0	NCCc1coc2ccc(C(N)=O)cc12	10.1016/S0960-894X(01)80331-0
		10105889	30955	1	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	244	3	1	2	2.8	COc1ccc2[nH]cc(C[C@@H]3CCCN3C)c2c1	10.1021/jm00101a032
		CHEMBL133939	30955	1	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	244	3	1	2	2.8	COc1ccc2[nH]cc(C[C@@H]3CCCN3C)c2c1	10.1021/jm00101a032
		132564	102433	8	None	-	4	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	230	2	1	3	2.0	Cn1cc(CCN)c2c3c(ccc21)OCCC3	10.1021/jm00098a005
		CHEMBL25800	102433	8	None	-	4	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	230	2	1	3	2.0	Cn1cc(CCN)c2c3c(ccc21)OCCC3	10.1021/jm00098a005
		10671996	125544	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	468	10	3	4	4.0	CNS(=O)(=O)Cc1ccc2[nH]cc(CCCN3CCC(N[C@H](C)c4ccccc4)CC3)c2c1	10.1021/jm9910021
		CHEMBL341897	125544	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	468	10	3	4	4.0	CNS(=O)(=O)Cc1ccc2[nH]cc(CCCN3CCC(N[C@H](C)c4ccccc4)CC3)c2c1	10.1021/jm9910021
		10696635	105685	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	497	10	3	5	4.3	COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1OCCN(C)C	10.1021/jm9811054
		CHEMBL279320	105685	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	497	10	3	5	4.3	COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1OCCN(C)C	10.1021/jm9811054
		42636941	185728	0	None	-	1	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]5OH-tryptamine rat recombinant 5HT1D receptorDisplacement of [3H]5OH-tryptamine rat recombinant 5HT1D receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		CHEMBL470432	185728	0	None	-	1	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]5OH-tryptamine rat recombinant 5HT1D receptorDisplacement of [3H]5OH-tryptamine rat recombinant 5HT1D receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		10600871	171729	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	483	5	2	7	4.7	Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1	10.1021/jm990397l
		CHEMBL422504	171729	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	483	5	2	7	4.7	Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1	10.1021/jm990397l
		14011045	42146	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	350	10	1	2	5.4	CCCN(CCC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		CHEMBL143745	42146	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	350	10	1	2	5.4	CCCN(CCC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		14011045	42146	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells	ChEMBL	350	10	1	2	5.4	CCCN(CCC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		CHEMBL143745	42146	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells	ChEMBL	350	10	1	2	5.4	CCCN(CCC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		19956256	122076	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was tested for binding affinity against 5-hydroxytryptamine 1D receptorCompound was tested for binding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	275	4	0	5	2.5	Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C	10.1016/s0960-894x(00)00691-0
		CHEMBL334923	122076	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was tested for binding affinity against 5-hydroxytryptamine 1D receptorCompound was tested for binding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	275	4	0	5	2.5	Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C	10.1016/s0960-894x(00)00691-0
		145	6928	49	None	-	30	Guinea pig	7.3	pIC50	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00101a032
		1832	6928	49	None	-	30	Guinea pig	7.3	pIC50	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00101a032
		CHEMBL7257	6928	49	None	-	30	Guinea pig	7.3	pIC50	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00101a032
		DB14010	6928	49	None	-	30	Guinea pig	7.3	pIC50	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00101a032
		145	6928	49	None	-2	30	Human	7.3	pIC50	=	7.3	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00098a005
		1832	6928	49	None	-2	30	Human	7.3	pIC50	=	7.3	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00098a005
		CHEMBL7257	6928	49	None	-2	30	Human	7.3	pIC50	=	7.3	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00098a005
		DB14010	6928	49	None	-2	30	Human	7.3	pIC50	=	7.3	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00098a005
		2543	10479	68	None	-1	32	Human	8.3	pIC50	=	8.3	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704558
		5358	10479	68	None	-1	32	Human	8.3	pIC50	=	8.3	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704558
		54	10479	68	None	-1	32	Human	8.3	pIC50	=	8.3	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704558
		CHEMBL128	10479	68	None	-1	32	Human	8.3	pIC50	=	8.3	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704558
		DB00669	10479	68	None	-1	32	Human	8.3	pIC50	=	8.3	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704558
		10601144	126166	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	490	11	2	6	4.3	COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccc(F)cc1	10.1021/jm9910021
		CHEMBL344537	126166	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	490	11	2	6	4.3	COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccc(F)cc1	10.1021/jm9910021
		2543	10479	68	None	-1	32	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
		5358	10479	68	None	-1	32	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
		54	10479	68	None	-1	32	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
		CHEMBL128	10479	68	None	-1	32	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
		DB00669	10479	68	None	-1	32	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9704560
		67650695	86302	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	500	8	2	5	4.9	F[C@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F	10.1021/jm981133m
		CHEMBL2114038	86302	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	500	8	2	5	4.9	F[C@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F	10.1021/jm981133m
		44323253	213256	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	297	7	2	4	2.9	c1ccc(NCCCNCC2CCc3ccccc3O2)nc1	10.1016/0960-894X(95)00473-7
		CHEMBL88207	213256	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	297	7	2	4	2.9	c1ccc(NCCCNCC2CCc3ccccc3O2)nc1	10.1016/0960-894X(95)00473-7
		10575553	209818	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		CHEMBL63432	209818	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		10504097	47167	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	9	3	6	3.6	CC(CO)(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL148194	47167	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	9	3	6	3.6	CC(CO)(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		11798502	63267	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	468	7	1	5	4.5	FC(F)(F)c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		CHEMBL163376	63267	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	468	7	1	5	4.5	FC(F)(F)c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm980569z
		10836290	62211	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	1	5	3.1	O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1CCc1ccccc1	10.1021/jm980569z
		CHEMBL161970	62211	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	8	1	5	3.1	O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1CCc1ccccc1	10.1021/jm980569z
		9803620	169239	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
		CHEMBL416688	169239	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm980204e
		9803620	169239	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		CHEMBL416688	169239	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	446	8	1	5	4.2	CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm981133m
		10551207	45372	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	442	9	2	5	4.4	C[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL146502	45372	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	442	9	2	5	4.4	C[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10766319	45532	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	10	3	6	3.9	OCCC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL146628	45532	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	10	3	6	3.9	OCCC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10623434	109089	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1ccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm981133m
		CHEMBL303514	109089	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1ccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm981133m
		10839082	46487	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	499	10	2	6	4.3	CC(=O)Nc1ccc(CCN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		CHEMBL147546	46487	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	499	10	2	6	4.3	CC(=O)Nc1ccc(CCN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1	10.1021/jm9910021
		10789717	86301	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(C[C@@H](F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		CHEMBL2114036	86301	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	450	8	1	5	3.6	Fc1cccc(CCN2CCN(C[C@@H](F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1	10.1021/jm981133m
		10528410	46156	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	471	8	2	5	4.6	CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1	10.1021/jm9910021
		CHEMBL147148	46156	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	471	8	2	5	4.6	CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1	10.1021/jm9910021
		10766321	46916	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	458	10	3	6	3.7	OC[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL147979	46916	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	458	10	3	6	3.7	OC[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		44322885	112712	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	329	7	3	4	1.8	CC(C)/N=C(\NC#N)NCCCNCC1CCc2ccccc2O1	10.1016/0960-894X(95)00473-7
		CHEMBL312845	112712	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	329	7	3	4	1.8	CC(C)/N=C(\NC#N)NCCCNCC1CCc2ccccc2O1	10.1016/0960-894X(95)00473-7
		10664878	96045	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	340	4	3	3	2.2	CC1(C)NC(=O)N(CCc2ccc3[nH]cc([C@H]4C[C@H](N)C4)c3c2)C1=O	10.1021/jm000956k
		CHEMBL2368255	96045	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	340	4	3	3	2.2	CC1(C)NC(=O)N(CCc2ccc3[nH]cc([C@H]4C[C@H](N)C4)c3c2)C1=O	10.1021/jm000956k
		107780	8625	54	None	-1	18	Human	7.3	pIC50	=	7.3	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm990397l
		14	8625	54	None	-1	18	Human	7.3	pIC50	=	7.3	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm990397l
		CHEMBL15928	8625	54	None	-1	18	Human	7.3	pIC50	=	7.3	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm990397l
		107780	8625	54	None	-	18	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm9811054
		14	8625	54	None	-	18	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm9811054
		CHEMBL15928	8625	54	None	-	18	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm9811054
		10694810	210546	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	449	8	1	4	5.3	FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(CCc2ccccc2)CC1	10.1021/jm981133m
		CHEMBL68019	210546	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	449	8	1	4	5.3	FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(CCc2ccccc2)CC1	10.1021/jm981133m
		10709057	126846	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	296	3	1	4	3.3	Cc1noc(-c2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1	10.1021/jm000956k
		CHEMBL350637	126846	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	296	3	1	4	3.3	Cc1noc(-c2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1	10.1021/jm000956k
		18691565	96047	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	327	4	1	3	3.0	CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1	10.1021/jm000956k
		CHEMBL2368257	96047	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	327	4	1	3	3.0	CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1	10.1021/jm000956k
		10719245	44582	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	472	10	2	6	4.1	CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1	10.1021/jm9910021
		CHEMBL145849	44582	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	472	10	2	6	4.1	CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1	10.1021/jm9910021
		10427186	212699	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	337	5	3	5	3.5	O=[N+]([O-])c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm00042a003
		CHEMBL84107	212699	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	337	5	3	5	3.5	O=[N+]([O-])c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm00042a003
		10719448	42377	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	478	9	2	6	3.4	O=S(=O)(NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL143952	42377	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	478	9	2	6	3.4	O=S(=O)(NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		10837853	174937	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	464	8	1	5	4.3	CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm981133m
		CHEMBL433108	174937	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	464	8	1	5	4.3	CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm981133m
		9930155	170811	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
		CHEMBL420874	170811	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9704558
		9930155	170811	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL420874	170811	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	387	7	1	5	3.6	c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		10552573	44915	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	476	10	4	5	3.5	O=C1N[C@@H](Cc2ccc3[nH]cc(CCCN4CCC(N[C@@H](CO)c5ccccc5)CC4)c3c2)CO1	10.1021/jm9910021
		CHEMBL146129	44915	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	476	10	4	5	3.5	O=C1N[C@@H](Cc2ccc3[nH]cc(CCCN4CCC(N[C@@H](CO)c5ccccc5)CC4)c3c2)CO1	10.1021/jm9910021
		44323254	213257	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	288	6	3	5	0.9	c1ccc2c(c1)CCC(CNCCCNC1=NCCN1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL88208	213257	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	288	6	3	5	0.9	c1ccc2c(c1)CCC(CNCCCNC1=NCCN1)O2	10.1016/0960-894X(95)00473-7
		10766235	85635	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	456	7	3	6	3.4	O[C@@H]1Cc2ccccc2[C@H]1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL2112862	85635	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	456	7	3	6	3.4	O[C@@H]1Cc2ccccc2[C@H]1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		9866484	63052	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	7	1	5	3.0	O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1	10.1021/jm980569z
		CHEMBL162899	63052	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	414	7	1	5	3.0	O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1	10.1021/jm980569z
		2543	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980569z
		5358	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980569z
		54	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980569z
		CHEMBL128	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980569z
		DB00669	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980569z
		2543	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805687
		5358	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805687
		54	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805687
		CHEMBL128	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805687
		DB00669	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805687
		2543	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9910021
		5358	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9910021
		54	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9910021
		CHEMBL128	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9910021
		DB00669	10479	68	None	-1	32	Human	8.2	pIC50	=	8.2	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9910021
		10526737	109519	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.5	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(CCc2ccccc2)CC1	10.1021/jm981133m
		CHEMBL304993	109519	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	8	1	5	3.5	FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(CCc2ccccc2)CC1	10.1021/jm981133m
		10505438	63129	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	496	9	1	8	3.9	Cc1noc(-c2ccc(CCN3CCN(CCCc4c[nH]c5ccc(-n6cnnc6)cc45)CC3)cc2)n1	10.1021/jm980569z
		CHEMBL163114	63129	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	496	9	1	8	3.9	Cc1noc(-c2ccc(CCN3CCN(CCCc4c[nH]c5ccc(-n6cnnc6)cc45)CC3)cc2)n1	10.1021/jm980569z
		131670	59294	7	None	-	0	Guinea pig	7.2	pIC50	=	7.2	Binding	Binding affinity towards guinea pig 5-hydroxytryptamine 1D receptor was determinedBinding affinity towards guinea pig 5-hydroxytryptamine 1D receptor was determined	ChEMBL	453	11	6	6	0.1	NCCc1c[nH]c2ccc(OCC(=O)NCC(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)cc12	10.1016/0960-894X(95)00091-7
		CHEMBL159174	59294	7	None	-	0	Guinea pig	7.2	pIC50	=	7.2	Binding	Binding affinity towards guinea pig 5-hydroxytryptamine 1D receptor was determinedBinding affinity towards guinea pig 5-hydroxytryptamine 1D receptor was determined	ChEMBL	453	11	6	6	0.1	NCCc1c[nH]c2ccc(OCC(=O)NCC(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)cc12	10.1016/0960-894X(95)00091-7
		10578117	50815	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	529	8	1	7	5.4	Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OCCF)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1	10.1021/jm990397l
		CHEMBL151420	50815	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	529	8	1	7	5.4	Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OCCF)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1	10.1021/jm990397l
		2543	10479	68	None	-2	32	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
		5358	10479	68	None	-2	32	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
		54	10479	68	None	-2	32	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
		CHEMBL128	10479	68	None	-2	32	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
		DB00669	10479	68	None	-2	32	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
		115	10563	80	None	-2	27	Human	6.2	pIC50	=	6.2	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	10.1021/jm00170a007
		4296	10563	80	None	-2	27	Human	6.2	pIC50	=	6.2	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	10.1021/jm00170a007
		CHEMBL274866	10563	80	None	-2	27	Human	6.2	pIC50	=	6.2	Binding	Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand	ChEMBL	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	10.1021/jm00170a007
		44323161	213345	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	288	5	3	5	0.9	c1ccc2c(c1)CCC(CNCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL88783	213345	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	288	5	3	5	0.9	c1ccc2c(c1)CCC(CNCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		10494885	96043	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	306	4	1	2	4.8	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1	10.1021/jm000956k
		CHEMBL2368253	96043	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	306	4	1	2	4.8	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1	10.1021/jm000956k
		9904205	212629	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity against 5-HT1D receptorBinding affinity against 5-HT1D receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(02)00796-5
		CHEMBL83658	212629	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity against 5-HT1D receptorBinding affinity against 5-HT1D receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(02)00796-5
		9904205	212629	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL83658	212629	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		10646633	58056	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	437	3	2	4	3.7	COc1ccc(NC(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)cc1N1CCN(C)CC1	10.1021/jm9811054
		CHEMBL15808	58056	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	437	3	2	4	3.7	COc1ccc(NC(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)cc1N1CCN(C)CC1	10.1021/jm9811054
		18691566	96046	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	299	4	3	3	2.3	CN[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		CHEMBL2368256	96046	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	299	4	3	3	2.3	CN[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		110	7957	18	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	321	5	2	3	1.9	CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C	10.1021/jm000956k
		132552	7957	18	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	321	5	2	3	1.9	CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C	10.1021/jm000956k
		CHEMBL159332	7957	18	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	321	5	2	3	1.9	CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C	10.1021/jm000956k
		44341798	16588	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	424	8	3	6	3.1	CC(C)(C)CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		CHEMBL113831	16588	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro	ChEMBL	424	8	3	6	3.1	CC(C)(C)CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1016/s0960-894x(99)00614-9
		11798621	47073	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	471	9	3	6	3.8	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1	10.1021/jm9910021
		CHEMBL148110	47073	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	471	9	3	6	3.8	C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1	10.1021/jm9910021
		10813769	127767	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	458	9	3	6	3.9	C[C@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		CHEMBL356315	127767	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	458	9	3	6	3.9	C[C@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1	10.1021/jm9910021
		11796808	59827	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	9	1	5	3.8	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1	10.1021/jm9805687
		CHEMBL159733	59827	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	428	9	1	5	3.8	CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1	10.1021/jm9805687
		44322886	213449	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	303	7	2	5	2.9	c1ccc2c(c1)CCC(CNCCCNc1nccs1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL89427	213449	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	303	7	2	5	2.9	c1ccc2c(c1)CCC(CNCCCNc1nccs1)O2	10.1016/0960-894X(95)00473-7
		44213967	213591	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	320	6	3	5	1.4	Fc1ccc2c(c1)CCC(CNCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		CHEMBL90405	213591	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra	ChEMBL	320	6	3	5	1.4	Fc1ccc2c(c1)CCC(CNCCCNC1=NCCCN1)O2	10.1016/0960-894X(95)00473-7
		10673854	51226	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	533	7	1	8	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm990397l
		CHEMBL151894	51226	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay	ChEMBL	533	7	1	8	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm990397l
		9845261	10948	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HTInhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT	ChEMBL	424	5	1	6	3.4	COc1cccc(CN2CCN(C3CCC(O)(c4ccc5c(c4)OCO5)CC3)CC2)c1	10.1016/s0960-894x(02)00879-x
		CHEMBL100086	10948	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HTInhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT	ChEMBL	424	5	1	6	3.4	COc1cccc(CN2CCN(C3CCC(O)(c4ccc5c(c4)OCO5)CC3)CC2)c1	10.1016/s0960-894x(02)00879-x
		10612178	126643	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	271	4	2	2	2.0	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(N)=O)cc32)C1	10.1021/jm000956k
		CHEMBL348811	126643	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	271	4	2	2	2.0	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(N)=O)cc32)C1	10.1021/jm000956k
		59022	127868	16	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	294	6	1	2	3.9	CN(C)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		CHEMBL357130	127868	16	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	294	6	1	2	3.9	CN(C)CCc1c[nH]c2ccc(OCc3ccccc3)cc12	10.1021/jm9604890
		26395	40990	7	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	232	5	2	2	2.8	CCN(CC)CCc1c[nH]c2ccc(O)cc12	10.1021/jm9604890
		CHEMBL142629	40990	7	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	232	5	2	2	2.8	CCN(CC)CCc1c[nH]c2ccc(O)cc12	10.1021/jm9604890
		26395	40990	7	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells	ChEMBL	232	5	2	2	2.8	CCN(CC)CCc1c[nH]c2ccc(O)cc12	10.1021/jm9604890
		CHEMBL142629	40990	7	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells	ChEMBL	232	5	2	2	2.8	CCN(CC)CCc1c[nH]c2ccc(O)cc12	10.1021/jm9604890
		44272402	74255	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate	ChEMBL	206	3	2	3	0.6	NCCC1COc2ccc(C(N)=O)cc21	10.1016/S0960-894X(01)80331-0
		CHEMBL18928	74255	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate	ChEMBL	206	3	2	3	0.6	NCCC1COc2ccc(C(N)=O)cc21	10.1016/S0960-894X(01)80331-0
		10694177	209887	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	435	7	1	4	4.9	FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1	10.1021/jm981133m
		CHEMBL64003	209887	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	435	7	1	4	4.9	FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1	10.1021/jm981133m
		2393	10107	82	None	1	5	Human	7.1	pIC50	=	7.1	Binding	Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00010a025
		5078	10107	82	None	1	5	Human	7.1	pIC50	=	7.1	Binding	Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00010a025
		51	10107	82	None	1	5	Human	7.1	pIC50	=	7.1	Binding	Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00010a025
		CHEMBL905	10107	82	None	1	5	Human	7.1	pIC50	=	7.1	Binding	Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00010a025
		DB00953	10107	82	None	1	5	Human	7.1	pIC50	=	7.1	Binding	Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00010a025
		44457907	91989	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	536	9	6	4	4.6	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		CHEMBL22553	91989	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype	ChEMBL	536	9	6	4	4.6	NC(=O)c1ccc2[nH]cc(C3=CCC(NCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1	10.1016/0960-894X(94)00470-Z
		10645715	47037	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	418	8	1	6	3.9	CN(Cc1ccoc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL148085	47037	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	418	8	1	6	3.9	CN(Cc1ccoc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10602052	126043	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	520	10	1	7	3.9	CN(Cc1ccc(S(C)(=O)=O)cc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL343667	126043	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	520	10	1	7	3.9	CN(Cc1ccc(S(C)(=O)=O)cc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10790076	46762	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	10	3	6	3.3	OC[C@@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL147853	46762	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	458	10	3	6	3.3	OC[C@@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10526642	176052	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	430	9	3	6	2.9	OC[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
		CHEMBL441296	176052	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	430	9	3	6	2.9	OC[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1	10.1021/jm9805687
		9802530	42160	1	None	2	4	Human	8.1	pIC50	=	8.1	Binding	Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.	ChEMBL	336	5	1	4	2.5	CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		CHEMBL143767	42160	1	None	2	4	Human	8.1	pIC50	=	8.1	Binding	Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.	ChEMBL	336	5	1	4	2.5	CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		10787241	61366	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	2	6	2.8	c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)ccn1	10.1021/jm9805687
		CHEMBL161066	61366	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	2	6	2.8	c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)ccn1	10.1021/jm9805687
		10671315	209790	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	451	8	1	5	4.6	FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1	10.1021/jm981133m
		CHEMBL63258	209790	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	451	8	1	5	4.6	FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1	10.1021/jm981133m
		10733823	63054	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	311	5	1	5	2.0	c1cc2[nH]cc(CCCN3CCOCC3)c2cc1-n1cnnc1	10.1021/jm980569z
		CHEMBL162930	63054	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	311	5	1	5	2.0	c1cc2[nH]cc(CCCN3CCOCC3)c2cc1-n1cnnc1	10.1021/jm980569z
		10836850	47051	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	440	7	2	5	4.4	c1ccc2c(c1)CCC2NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL148095	47051	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	440	7	2	5	4.4	c1ccc2c(c1)CCC2NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		169764	39888	8	None	-	2	Human	6.1	pIC50	=	6.1	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	260	7	2	2	3.5	CCCN(CCC)CCc1c[nH]c2ccc(O)cc12	10.1021/jm9604890
		CHEMBL141706	39888	8	None	-	2	Human	6.1	pIC50	=	6.1	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	260	7	2	2	3.5	CCCN(CCC)CCc1c[nH]c2ccc(O)cc12	10.1021/jm9604890
		169764	39888	8	None	-	2	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells	ChEMBL	260	7	2	2	3.5	CCCN(CCC)CCc1c[nH]c2ccc(O)cc12	10.1021/jm9604890
		CHEMBL141706	39888	8	None	-	2	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells	ChEMBL	260	7	2	2	3.5	CCCN(CCC)CCc1c[nH]c2ccc(O)cc12	10.1021/jm9604890
		18366015	85147	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity against calf caudate 5-hydroxytryptamine 1D receptorBinding affinity against calf caudate 5-hydroxytryptamine 1D receptor	ChEMBL	313	4	2	3	2.6	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		CHEMBL2110300	85147	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity against calf caudate 5-hydroxytryptamine 1D receptorBinding affinity against calf caudate 5-hydroxytryptamine 1D receptor	ChEMBL	313	4	2	3	2.6	CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1	10.1021/jm000956k
		10780344	126714	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	297	4	2	5	1.4	O[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		CHEMBL349528	126714	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	297	4	2	5	1.4	O[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1	10.1021/jm9805687
		10500370	59564	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	386	7	2	5	3.7	c1ccc(NC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		CHEMBL159493	59564	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	386	7	2	5	3.7	c1ccc(NC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1	10.1021/jm9805687
		10811964	175113	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	418	8	1	6	3.9	CN(Cc1ccco1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL434315	175113	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	418	8	1	6	3.9	CN(Cc1ccco1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		71450983	86424	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	514	8	1	5	5.2	CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F	10.1021/jm981133m
		CHEMBL2115112	86424	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	514	8	1	5	5.2	CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F	10.1021/jm981133m
		10786628	45229	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	390	7	1	5	3.1	CC#CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		CHEMBL146396	45229	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.	ChEMBL	390	7	1	5	3.1	CC#CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1	10.1021/jm9910021
		10625376	59225	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	505	5	3	4	4.7	CN1CCC2(CC1)COc1ccc(NC(=O)NCCN3CCC(c4c[nH]c5cc(F)ccc45)CC3)cc12	10.1021/jm9811054
		CHEMBL15909	59225	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	505	5	3	4	4.7	CN1CCC2(CC1)COc1ccc(NC(=O)NCCN3CCC(c4c[nH]c5cc(F)ccc45)CC3)cc12	10.1021/jm9811054
		10552023	105379	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	462	2	2	3	5.1	CN1CCC2(CC1)COc1ccc(NC(=O)N3CCC(c4c[nH]c5ccc(F)cc45)CC3)cc12	10.1021/jm9811054
		CHEMBL276928	105379	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.	ChEMBL	462	2	2	3	5.1	CN1CCC2(CC1)COc1ccc(NC(=O)N3CCC(c4c[nH]c5ccc(F)cc45)CC3)cc12	10.1021/jm9811054
		10244251	103499	0	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	258	3	0	3	2.6	CN(C)CCc1cn(C)c2ccc3c(c12)CCCO3	10.1021/jm00098a005
		CHEMBL26427	103499	0	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand	ChEMBL	258	3	0	3	2.6	CN(C)CCc1cn(C)c2ccc3c(c12)CCCO3	10.1021/jm00098a005
		10757342	61881	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	310	4	1	4	3.3	Cc1noc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1	10.1021/jm000956k
		CHEMBL161694	61881	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor	ChEMBL	310	4	1	4	3.3	Cc1noc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1	10.1021/jm000956k
		10834908	59439	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	1	5	4.0	c1ccc(COC[C@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1	10.1021/jm9805687
		CHEMBL159381	59439	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	ChEMBL	401	8	1	5	4.0	c1ccc(COC[C@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1	10.1021/jm9805687
		2869	10924	89	None	-2	7	Human	8.8	pKd	=	8.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		60	10924	89	None	-2	7	Human	8.8	pKd	=	8.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		60857	10924	89	None	-2	7	Human	8.8	pKd	=	8.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		CHEMBL1185	10924	89	None	-2	7	Human	8.8	pKd	=	8.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		DB00315	10924	89	None	-2	7	Human	8.8	pKd	=	8.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		2030	10444	10	None	-158	10	Human	7.0	pKd	=	7.0	Binding	Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor	ChEMBL	464	4	0	6	3.0	COc1cccc2c1C[C@H]1C[C@H](CN([C@@H]1C2)C)C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-]	10.1016/j.bmcl.2007.04.086
		5311377	10444	10	None	-158	10	Human	7.0	pKd	=	7.0	Binding	Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor	ChEMBL	464	4	0	6	3.0	COc1cccc2c1C[C@H]1C[C@H](CN([C@@H]1C2)C)C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-]	10.1016/j.bmcl.2007.04.086
		CHEMBL251541	10444	10	None	-158	10	Human	7.0	pKd	=	7.0	Binding	Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor	ChEMBL	464	4	0	6	3.0	COc1cccc2c1C[C@H]1C[C@H](CN([C@@H]1C2)C)C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-]	10.1016/j.bmcl.2007.04.086
		11655728	23416	8	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation countingDisplacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation counting	ChEMBL	468	5	1	7	3.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
		CHEMBL1241913	23416	8	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation countingDisplacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation counting	ChEMBL	468	5	1	7	3.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
		11797998	42466	0	None	-1	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	454	10	4	4	4.8	NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12	10.1021/jm7011722
		CHEMBL144030	42466	0	None	-1	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	454	10	4	4	4.8	NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12	10.1021/jm7011722
		107780	8625	54	None	-1	18	Human	9.9	pKi	=	9.9	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor betaBinding affinity against 5-hydroxytryptamine 1D receptor beta	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm00041a001
		14	8625	54	None	-1	18	Human	9.9	pKi	=	9.9	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor betaBinding affinity against 5-hydroxytryptamine 1D receptor beta	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm00041a001
		CHEMBL15928	8625	54	None	-1	18	Human	9.9	pKi	=	9.9	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor betaBinding affinity against 5-hydroxytryptamine 1D receptor beta	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm00041a001
		49850870	63163	0	None	6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631535	63163	0	None	6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
		49850673	63166	0	None	10	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	418	6	1	5	4.5	CCOC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1631538	63166	0	None	10	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	418	6	1	5	4.5	CCOC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		11304596	63170	0	None	2	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631542	63170	0	None	2	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		49850772	63173	0	None	3	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631545	63173	0	None	3	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		49852002	63234	0	None	10	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	416	6	1	4	4.5	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632208	63234	0	None	10	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	416	6	1	4	4.5	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1	10.1021/jm100714c
		49850984	63241	0	None	10	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	480	7	1	5	5.2	COc1cccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)c1	10.1021/jm100714c
		CHEMBL1632215	63241	0	None	10	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	480	7	1	5	5.2	COc1cccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)c1	10.1021/jm100714c
		49850570	63246	0	None	7	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1632220	63246	0	None	7	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		49850571	63247	0	None	12	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	431	7	2	4	4.4	CCCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1632221	63247	0	None	12	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	431	7	2	4	4.4	CCCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		9909089	193747	0	None	-1	7	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL490417	193747	0	None	-1	7	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1021/jm100714c
		9909089	193747	0	None	-1	7	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL490417	193747	0	None	-1	7	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		10319235	193916	0	None	3	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	407	4	1	5	3.1	CC1(C)Cc2cccc(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)c2O1	10.1016/j.bmcl.2008.08.084
		CHEMBL491839	193916	0	None	3	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	407	4	1	5	3.1	CC1(C)Cc2cccc(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)c2O1	10.1016/j.bmcl.2008.08.084
		10071738	199378	0	None	1	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	436	4	1	5	3.9	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL521506	199378	0	None	1	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	436	4	1	5	3.9	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2008.08.084
		9957376	182936	0	None	15	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	457	7	0	4	5.7	Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCN(C)CC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL459282	182936	0	None	15	3	Human	9.7	pKi	=	9.7	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	457	7	0	4	5.7	Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCN(C)CC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		49850669	63161	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	483	6	2	4	5.7	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5F)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631533	63161	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	483	6	2	4	5.7	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5F)c4)CC3)cccc2n1	10.1021/jm100714c
		11292933	63168	45	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631540	63168	45	None	1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		49852001	63233	0	None	6	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	402	6	1	4	4.3	CCC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1632207	63233	0	None	6	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	402	6	1	4	4.3	CCC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		49850567	63243	0	None	2	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632217	63243	0	None	2	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
		9977716	176909	0	None	1	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	390	4	2	4	3.2	Cc1cc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2[nH]1	10.1016/j.bmcl.2008.08.084
		CHEMBL444398	176909	0	None	1	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	390	4	2	4	3.2	Cc1cc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2[nH]1	10.1016/j.bmcl.2008.08.084
		10477223	191796	0	None	12	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	420	4	1	5	3.4	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL485491	191796	0	None	12	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	420	4	1	5	3.4	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2008.08.084
		10454807	193612	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	420	4	1	5	3.4	Cc1ccc2c(N3CCN(CCc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL489394	193612	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	420	4	1	5	3.4	Cc1ccc2c(N3CCN(CCc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		10478217	194866	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	436	4	1	5	3.9	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL497980	194866	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	436	4	1	5	3.9	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1	10.1016/j.bmcl.2008.08.084
		9909089	193747	0	None	-1	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL490417	193747	0	None	-1	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		44292365	194889	0	None	61	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	270	2	1	1	4.1	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C(C)(C)C)cc12	10.1016/s0960-894x(00)00322-x
		CHEMBL49826	194889	0	None	61	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	270	2	1	1	4.1	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C(C)(C)C)cc12	10.1016/s0960-894x(00)00322-x
		10150796	74382	0	None	251	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	401	6	1	5	3.6	Cc1ccc2c(OCCN3CCN(Cc4cccc5[nH]cnc45)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL190298	74382	0	None	251	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	401	6	1	5	3.6	Cc1ccc2c(OCCN3CCN(Cc4cccc5[nH]cnc45)CC3)cccc2n1	10.1021/jm049039v
		49850672	63160	0	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1631532	63160	0	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		49850770	63171	0	None	10	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	430	5	0	5	4.3	Cc1ccc2c(N3CCN(CCc4cccc(N5CCCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631543	63171	0	None	10	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	430	5	0	5	4.3	Cc1ccc2c(N3CCN(CCc4cccc(N5CCCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		49850872	63232	0	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1632206	63232	0	None	1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		11419978	63237	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	468	6	1	4	5.3	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5F)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632211	63237	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	468	6	1	4	5.3	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5F)c4)CC3)cccc2n1	10.1021/jm100714c
		49850569	63245	0	None	1	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	471	6	1	6	4.9	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5scnc5C)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632219	63245	0	None	1	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	471	6	1	6	4.9	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5scnc5C)c4)CC3)cccc2n1	10.1021/jm100714c
		49850668	63248	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	445	5	2	4	4.8	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)NC(C)(C)C)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632222	63248	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	445	5	2	4	4.8	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)NC(C)(C)C)c4)CC3)cccc2n1	10.1021/jm100714c
		10023176	193725	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	388	4	1	5	2.9	O=C1COc2ccc(CCN3CCN(c4nccc5ccccc45)CC3)cc2N1	10.1016/j.bmcl.2008.08.084
		CHEMBL490211	193725	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	388	4	1	5	2.9	O=C1COc2ccc(CCN3CCN(c4nccc5ccccc45)CC3)cc2N1	10.1016/j.bmcl.2008.08.084
		10387420	194633	0	None	-1	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	420	4	1	5	3.4	Cc1ccc2c(N3CCN(CCc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL496317	194633	0	None	-1	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	420	4	1	5	3.4	Cc1ccc2c(N3CCN(CCc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		10452875	199944	0	None	6	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	388	4	1	5	2.9	O=C1COc2ccc(CCN3CCN(c4cccc5cccnc45)CC3)cc2N1	10.1016/j.bmcl.2008.08.084
		CHEMBL523095	199944	0	None	6	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	388	4	1	5	2.9	O=C1COc2ccc(CCN3CCN(c4cccc5cccnc45)CC3)cc2N1	10.1016/j.bmcl.2008.08.084
		10151492	200161	0	None	100	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	446	8	2	4	5.0	CCNC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		CHEMBL525362	200161	0	None	100	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	446	8	2	4	5.0	CCNC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		9983460	19159	0	None	58	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	500	9	3	6	1.6	CN(C)S(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL118563	19159	0	None	58	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	500	9	3	6	1.6	CN(C)S(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL1203216	19159	0	None	58	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	500	9	3	6	1.6	CN(C)S(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		44292375	175953	0	None	36	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	256	3	1	1	3.9	CC(C)c1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1016/s0960-894x(00)00322-x
		CHEMBL44054	175953	0	None	36	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	256	3	1	1	3.9	CC(C)c1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1016/s0960-894x(00)00322-x
		10047915	120299	0	None	12	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	423	7	2	6	2.3	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4[N+](=O)[O-])CC3)cc12	10.1021/jm00018a020
		CHEMBL332142	120299	0	None	12	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	423	7	2	6	2.3	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4[N+](=O)[O-])CC3)cc12	10.1021/jm00018a020
		44394222	134332	0	None	39	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	245	1	2	3	3.0	Cc1cc(C(C)(C)C)cc(C)c1NC1=NCCN1	10.1016/j.bmcl.2004.06.085
		CHEMBL366322	134332	0	None	39	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	245	1	2	3	3.0	Cc1cc(C(C)(C)C)cc(C)c1NC1=NCCN1	10.1016/j.bmcl.2004.06.085
		6160690	126099	37	None	-28	3	Human	9.5	pKi	=	9.5	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	377	8	2	3	3.6	COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1	10.1021/jm9604890
		CHEMBL344127	126099	37	None	-28	3	Human	9.5	pKi	=	9.5	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	377	8	2	3	3.6	COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1	10.1021/jm9604890
		24882193	195428	0	None	263	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL503468	195428	0	None	263	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		10321497	21411	0	None	123	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	449	10	3	5	3.5	NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL120514	21411	0	None	123	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	449	10	3	5	3.5	NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		10342552	16708	0	None	9	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	428	4	2	2	5.4	Cc1ccc(NC(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		CHEMBL114571	16708	0	None	9	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	428	4	2	2	5.4	Cc1ccc(NC(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		49850768	63167	0	None	6	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	402	5	0	4	3.9	CC(=O)N(C)c1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1631539	63167	0	None	6	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	402	5	0	4	3.9	CC(=O)N(C)c1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		49850769	63169	0	None	10	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	429	5	1	4	3.8	Cc1ccc2c(N3CCN(CCc4cccc(N5CCCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631541	63169	0	None	10	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	429	5	1	4	3.8	Cc1ccc2c(N3CCN(CCc4cccc(N5CCCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		49852003	63235	0	None	6	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	430	5	1	4	4.9	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)(C)C)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632209	63235	0	None	6	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	430	5	1	4	4.9	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)(C)C)c4)CC3)cccc2n1	10.1021/jm100714c
		49850874	63236	0	None	3	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632210	63236	0	None	3	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
		49850877	63238	0	None	1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	468	6	1	4	5.3	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cccc(F)c5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632212	63238	0	None	1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	468	6	1	4	5.3	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cccc(F)c5)c4)CC3)cccc2n1	10.1021/jm100714c
		11397149	63249	0	None	10	7	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	465	6	2	4	5.6	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632223	63249	0	None	10	7	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	465	6	2	4	5.6	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
		10341129	193577	0	None	1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	403	4	1	6	2.6	Cc1ncc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL489195	193577	0	None	1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	403	4	1	6	2.6	Cc1ncc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		10319737	194542	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	416	4	1	5	3.6	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3C)cccc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL495705	194542	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	416	4	1	5	3.6	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3C)cccc2n1	10.1016/j.bmcl.2008.08.084
		44580784	194865	0	None	-1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	420	4	1	5	3.4	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL497979	194865	0	None	-1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	420	4	1	5	3.4	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1	10.1016/j.bmcl.2008.08.084
		9979309	199761	0	None	-1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL522257	199761	0	None	-1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		10194820	195643	0	None	158	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	432	7	0	5	3.7	CC(=O)N(C)c1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		CHEMBL506942	195643	0	None	158	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	432	7	0	5	3.7	CC(=O)N(C)c1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		4209	9937	75	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm980506g
		4893	9937	75	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm980506g
		503	9937	75	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm980506g
		5385	9937	75	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm980506g
		CHEMBL2	9937	75	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm980506g
		DB00457	9937	75	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm980506g
		10254537	22030	0	None	32	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	479	11	2	6	3.9	NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL121207	22030	0	None	32	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	479	11	2	6	3.9	NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		10321497	21411	0	None	123	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	449	10	3	5	3.5	NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL120514	21411	0	None	123	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	449	10	3	5	3.5	NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		44342784	16599	0	None	3	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	444	4	2	2	5.8	Cc1ccc(/N=C(\S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		CHEMBL113950	16599	0	None	3	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	444	4	2	2	5.8	Cc1ccc(/N=C(\S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		44342518	16746	0	None	10	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	448	4	2	2	5.8	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4ccc(Cl)cc4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL114780	16746	0	None	10	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	448	4	2	2	5.8	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4ccc(Cl)cc4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		10408880	21008	0	None	25	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	403	6	2	5	2.3	N#Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		CHEMBL119927	21008	0	None	25	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	403	6	2	5	2.3	N#Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		10275633	98729	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL241463	98729	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2006.11.031
		49850980	63239	0	None	3	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	468	6	1	4	5.3	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccc(F)cc5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632213	63239	0	None	3	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	468	6	1	4	5.3	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccc(F)cc5)c4)CC3)cccc2n1	10.1021/jm100714c
		49850568	63244	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	471	6	1	6	4.9	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5csc(C)n5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1632218	63244	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	471	6	1	6	4.9	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5csc(C)n5)c4)CC3)cccc2n1	10.1021/jm100714c
		44443130	100544	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	464	6	0	6	3.2	Cc1ccc2c(OCCN3CCN(Cc4cc(F)c5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		CHEMBL247428	100544	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	464	6	0	6	3.2	Cc1ccc2c(OCCN3CCN(Cc4cc(F)c5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		10001971	191103	0	None	-3	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	416	4	1	5	3.5	Cc1cc(N2CCN(CCc3ccc4c(c3)NC(=O)CO4)CC2)c2ccc(C)nc2c1	10.1016/j.bmcl.2008.08.084
		CHEMBL484260	191103	0	None	-3	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	416	4	1	5	3.5	Cc1cc(N2CCN(CCc3ccc4c(c3)NC(=O)CO4)CC2)c2ccc(C)nc2c1	10.1016/j.bmcl.2008.08.084
		10048342	193611	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	430	5	0	5	3.7	CCN1C(=O)COc2ccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cc21	10.1016/j.bmcl.2008.08.084
		CHEMBL489393	193611	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	430	5	0	5	3.7	CCN1C(=O)COc2ccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cc21	10.1016/j.bmcl.2008.08.084
		10454806	194664	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	420	4	1	5	3.4	Cc1ccc2c(N3CCN(CCc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL496520	194664	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	420	4	1	5	3.4	Cc1ccc2c(N3CCN(CCc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.084
		10174199	194472	0	None	3	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	481	9	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(=O)(=O)C(C)C)c4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL495213	194472	0	None	3	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	481	9	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(=O)(=O)C(C)C)c4)CC3)cccc2n1	10.1021/jm8001444
		9999722	170961	0	None	16	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL421064	170961	0	None	16	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1021/jm00018a020
		2762737	108627	20	None	35	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	230	4	1	1	3.4	CC(C)c1ccc2[nH]cc(CCN(C)C)c2c1	10.1016/s0960-894x(00)00322-x
		CHEMBL300519	108627	20	None	35	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	230	4	1	1	3.4	CC(C)c1ccc2[nH]cc(CCN(C)C)c2c1	10.1016/s0960-894x(00)00322-x
		44373641	127017	0	None	10	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	408	7	2	5	2.4	COc1cccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)c1	10.1016/0960-894X(95)00091-7
		CHEMBL352234	127017	0	None	10	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	408	7	2	5	2.4	COc1cccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)c1	10.1016/0960-894X(95)00091-7
		124	9755	47	None	-1	32	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm970513p
		2032	9755	47	None	-1	32	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm970513p
		4636	9755	47	None	-1	32	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm970513p
		CHEMBL762	9755	47	None	-1	32	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm970513p
		DB00935	9755	47	None	-1	32	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm970513p
		44279525	112289	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	444	8	2	5	4.0	CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1	10.1016/s0960-894x(98)00222-4
		CHEMBL31217	112289	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	444	8	2	5	4.0	CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1	10.1016/s0960-894x(98)00222-4
		44279525	112289	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	444	8	2	5	4.0	CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL31217	112289	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	444	8	2	5	4.0	CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1	10.1021/jm7011722
		10477386	121868	1	None	40	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	423	7	2	6	2.3	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL334323	121868	1	None	40	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	423	7	2	6	2.3	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		44342830	174760	0	None	10	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	444	5	2	3	5.1	COc1ccc(NC(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		CHEMBL431866	174760	0	None	10	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	444	5	2	3	5.1	COc1ccc(NC(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		10490521	172043	1	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	244	3	1	1	3.6	CN(C)CCc1c[nH]c2ccc(C(C)(C)C)cc12	10.1021/jm9805945
		CHEMBL423029	172043	1	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	244	3	1	1	3.6	CN(C)CCc1c[nH]c2ccc(C(C)(C)C)cc12	10.1021/jm9805945
		44292364	108802	2	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	230	2	1	2	3.0	Cn1cc(CCN)c2cc(C(C)(C)C)ccc21	10.1016/s0960-894x(00)00322-x
		CHEMBL301757	108802	2	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	230	2	1	2	3.0	Cn1cc(CCN)c2cc(C(C)(C)C)ccc21	10.1016/s0960-894x(00)00322-x
		44342508	16595	0	None	8	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	464	4	2	2	6.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4cccc5ccccc45)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL113893	16595	0	None	8	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	464	4	2	2	6.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4cccc5ccccc45)CC3)cc12	10.1016/s0960-894x(03)00779-0
		44342722	117320	0	None	10	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	414	4	2	2	5.1	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4ccccc4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL325175	117320	0	None	10	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	414	4	2	2	5.1	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4ccccc4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		10376578	127857	3	None	4	3	Human	9.4	pKi	=	9.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	230	3	2	1	3.2	CNCCc1c[nH]c2ccc(C(C)(C)C)cc12	10.1021/jm9805945
		CHEMBL357034	127857	3	None	4	3	Human	9.4	pKi	=	9.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	230	3	2	1	3.2	CNCCc1c[nH]c2ccc(C(C)(C)C)cc12	10.1021/jm9805945
		10649124	26242	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	502	5	0	7	3.1	CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6c5OCCO6)CC4)cc23)CC1	10.1021/jm9703552
		CHEMBL129813	26242	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	502	5	0	7	3.1	CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6c5OCCO6)CC4)cc23)CC1	10.1021/jm9703552
		44342785	16607	0	None	5	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	460	5	2	3	5.3	COc1ccc(NC(=S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		CHEMBL113994	16607	0	None	5	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	460	5	2	3	5.3	COc1ccc(NC(=S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		10254537	22030	0	None	32	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	479	11	2	6	3.9	NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL121207	22030	0	None	32	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	479	11	2	6	3.9	NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		44214329	66213	0	None	33	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	270	4	1	2	4.0	CN(C)CCc1c[nH]c2ccc(-c3ccsc3)cc12	10.1016/s0960-894x(00)00133-5
		CHEMBL171129	66213	0	None	33	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	270	4	1	2	4.0	CN(C)CCc1c[nH]c2ccc(-c3ccsc3)cc12	10.1016/s0960-894x(00)00133-5
		44279549	106216	0	None	1	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	606	11	4	7	4.6	CN1CCN(c2cccc3ccc(OCC(=O)Nc4ccc(NC(=O)COc5ccc6[nH]cc(CCN)c6c5)cc4)cc23)CC1	10.1016/s0960-894x(98)00222-4
		CHEMBL282950	106216	0	None	1	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	606	11	4	7	4.6	CN1CCN(c2cccc3ccc(OCC(=O)Nc4ccc(NC(=O)COc5ccc6[nH]cc(CCN)c6c5)cc4)cc23)CC1	10.1016/s0960-894x(98)00222-4
		5	6927	72	None	-6	53	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm7011722
		5202	6927	72	None	-6	53	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm7011722
		CHEMBL39	6927	72	None	-6	53	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm7011722
		DB08839	6927	72	None	-6	53	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm7011722
		10195275	182471	0	None	1	3	Human	9.3	pKi	=	9.3	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	458	7	0	5	4.6	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)CC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL458199	182471	0	None	1	3	Human	9.3	pKi	=	9.3	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	458	7	0	5	4.6	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)CC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		24865725	194863	0	None	3	12	Human	9.3	pKi	=	9.3	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL497963	194863	0	None	3	12	Human	9.3	pKi	=	9.3	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		49852105	63162	0	None	15	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	346	4	1	4	3.5	Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631534	63162	0	None	15	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	346	4	1	4	3.5	Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1	10.1021/jm100714c
		49850671	63165	0	None	5	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	483	6	2	4	5.7	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccc(F)cc5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631537	63165	0	None	5	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	483	6	2	4	5.7	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccc(F)cc5)c4)CC3)cccc2n1	10.1021/jm100714c
		49850566	63242	0	None	6	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	480	7	1	5	5.2	COc1ccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)cc1	10.1021/jm100714c
		CHEMBL1632216	63242	0	None	6	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	480	7	1	5	5.2	COc1ccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)cc1	10.1021/jm100714c
		24865725	194863	0	None	3	12	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL497963	194863	0	None	3	12	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
		44443131	100585	0	None	3	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	464	6	0	6	3.2	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4F)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		CHEMBL247609	100585	0	None	3	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	464	6	0	6	3.2	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4F)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		44443093	161472	0	None	7	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	446	6	0	6	3.1	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		CHEMBL399719	161472	0	None	7	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	446	6	0	6	3.1	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		44580741	199449	0	None	3	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	416	4	1	5	3.6	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@H](C)C3)cccc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL521873	199449	0	None	3	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	416	4	1	5	3.6	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@H](C)C3)cccc2n1	10.1016/j.bmcl.2008.08.084
		10237964	194393	0	None	39	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	418	7	1	5	3.7	CC(=O)Nc1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		CHEMBL494806	194393	0	None	39	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	418	7	1	5	3.7	CC(=O)Nc1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		24865725	194863	0	None	3	12	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL497963	194863	0	None	3	12	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		10173263	200178	0	None	39	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	417	7	1	4	4.8	CC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		CHEMBL525712	200178	0	None	39	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	417	7	1	4	4.8	CC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		44404240	79302	0	None	-1	3	Human	9.3	pKi	=	9.3	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	441	2	0	5	3.6	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C(F)(F)F)nc2)CC4)CC1	10.1016/j.bmcl.2005.06.042
		CHEMBL199088	79302	0	None	-1	3	Human	9.3	pKi	=	9.3	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	441	2	0	5	3.6	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C(F)(F)F)nc2)CC4)CC1	10.1016/j.bmcl.2005.06.042
		44404225	140311	0	None	-1	3	Human	9.3	pKi	=	9.3	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	406	2	0	4	3.8	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(Cl)cc2)CC4)CC1	10.1016/j.bmcl.2005.06.042
		CHEMBL370852	140311	0	None	-1	3	Human	9.3	pKi	=	9.3	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	406	2	0	4	3.8	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(Cl)cc2)CC4)CC1	10.1016/j.bmcl.2005.06.042
		10838063	85551	0	None	-1	3	Human	9.3	pKi	=	9.3	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	469	5	0	6	3.2	CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5ccccc5C#N)CC4)cc23)CC1	10.1021/jm9703552
		CHEMBL2112660	85551	0	None	-1	3	Human	9.3	pKi	=	9.3	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	469	5	0	6	3.2	CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5ccccc5C#N)CC4)cc23)CC1	10.1021/jm9703552
		10048222	60771	0	None	12	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	428	6	2	4	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4cccc5ccccc45)CC3)cc12	10.1016/0960-894X(95)00091-7
		CHEMBL160581	60771	0	None	12	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	428	6	2	4	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4cccc5ccccc45)CC3)cc12	10.1016/0960-894X(95)00091-7
		10458088	21377	0	None	5	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	485	9	3	6	1.4	CS(=O)(=O)NCc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		CHEMBL120480	21377	0	None	5	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	485	9	3	6	1.4	CS(=O)(=O)NCc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		44560995	185932	0	None	34	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor	ChEMBL	498	5	2	5	4.7	FC(F)(F)c1nc2c(N3CCN(CCOc4cccc5nc(C(F)(F)F)[nH]c45)CC3)cccc2[nH]1	10.1016/j.bmc.2008.05.024
		CHEMBL472117	185932	0	None	34	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor	ChEMBL	498	5	2	5	4.7	FC(F)(F)c1nc2c(N3CCN(CCOc4cccc5nc(C(F)(F)F)[nH]c45)CC3)cccc2[nH]1	10.1016/j.bmc.2008.05.024
		71461632	85553	0	None	-2	3	Human	9.3	pKi	=	9.3	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	472	6	0	5	3.6	Cc1ccccc1CN1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1	10.1021/jm9703552
		CHEMBL2112662	85553	0	None	-2	3	Human	9.3	pKi	=	9.3	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	472	6	0	5	3.6	Cc1ccccc1CN1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1	10.1021/jm9703552
		10344705	22319	0	None	56	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	471	8	3	6	1.8	CS(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL121901	22319	0	None	56	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	471	8	3	6	1.8	CS(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		44342506	16897	0	None	2	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	464	4	2	2	6.2	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4ccc(Cl)cc4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL115663	16897	0	None	2	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	464	4	2	2	6.2	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4ccc(Cl)cc4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		10047915	120299	0	None	12	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	423	7	2	6	2.3	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4[N+](=O)[O-])CC3)cc12	10.1021/jm00018a020
		CHEMBL332142	120299	0	None	12	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	423	7	2	6	2.3	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4[N+](=O)[O-])CC3)cc12	10.1021/jm00018a020
		9999722	170961	0	None	16	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1016/0960-894X(95)00091-7
		CHEMBL421064	170961	0	None	16	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1016/0960-894X(95)00091-7
		24881617	195105	0	None	165	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	756	13	4	4	10.1	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL500737	195105	0	None	165	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	756	13	4	4	10.1	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		2762736	176867	21	None	-	1	Human	9.2	pKi	=	9.2	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	216	2	2	1	3.0	CC(C)(C)c1ccc2[nH]cc(CCN)c2c1	10.1021/jm9805945
		CHEMBL444341	176867	21	None	-	1	Human	9.2	pKi	=	9.2	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	216	2	2	1	3.0	CC(C)(C)c1ccc2[nH]cc(CCN)c2c1	10.1021/jm9805945
		10601619	123614	0	None	-1	3	Human	9.2	pKi	=	9.2	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	504	7	0	7	3.3	COc1cccc(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c1OC	10.1021/jm9703552
		CHEMBL338015	123614	0	None	-1	3	Human	9.2	pKi	=	9.2	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	504	7	0	7	3.3	COc1cccc(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c1OC	10.1021/jm9703552
		10127877	196341	0	None	3	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	472	7	0	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCN(C)CC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL514429	196341	0	None	3	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	472	7	0	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCN(C)CC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		10238566	196807	0	None	3	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	458	7	1	5	4.7	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@H](C)C5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL517170	196807	0	None	3	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	458	7	1	5	4.7	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@H](C)C5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		49850670	63164	0	None	6	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	483	6	2	4	5.7	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5cccc(F)c5)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631536	63164	0	None	6	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	483	6	2	4	5.7	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5cccc(F)c5)c4)CC3)cccc2n1	10.1021/jm100714c
		49852000	63174	0	None	2	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	452	8	1	5	4.1	CCCS(=O)(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1631548	63174	0	None	2	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	452	8	1	5	4.1	CCCS(=O)(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		49850982	63240	0	None	3	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	480	7	1	5	5.2	COc1ccccc1C(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		CHEMBL1632214	63240	0	None	3	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	480	7	1	5	5.2	COc1ccccc1C(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
		10194809	194905	0	None	25	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	431	8	1	4	5.2	CCC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		CHEMBL498354	194905	0	None	25	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	431	8	1	4	5.2	CCC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		9955522	79264	0	None	-1	3	Human	9.2	pKi	=	9.2	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	452	3	0	6	3.7	Cc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccccc1	10.1016/j.bmcl.2005.06.042
		CHEMBL198975	79264	0	None	-1	3	Human	9.2	pKi	=	9.2	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	452	3	0	6	3.7	Cc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccccc1	10.1016/j.bmcl.2005.06.042
		9957274	142079	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	491	4	0	7	3.8	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		CHEMBL372743	142079	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	491	4	0	7	3.8	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		44342767	121737	0	None	8	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	430	4	2	2	5.5	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4ccccc4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL334259	121737	0	None	8	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	430	4	2	2	5.5	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4ccccc4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		9955819	124922	0	None	-2	3	Human	9.2	pKi	=	9.2	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	458	5	0	5	3.6	Cc1ccccc1N1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1	10.1021/jm9703552
		CHEMBL340786	124922	0	None	-2	3	Human	9.2	pKi	=	9.2	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	458	5	0	5	3.6	Cc1ccccc1N1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1	10.1021/jm9703552
		107780	8625	54	None	-1	18	Human	9.2	pKi	=	9.2	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/S0960-894X(97)10164-0
		14	8625	54	None	-1	18	Human	9.2	pKi	=	9.2	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/S0960-894X(97)10164-0
		CHEMBL15928	8625	54	None	-1	18	Human	9.2	pKi	=	9.2	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/S0960-894X(97)10164-0
		107780	8625	54	None	-1	18	Human	9.2	pKi	=	9.2	Binding	Affinity towards cloned human 5-hydroxytryptamine 1D receptorAffinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/j.bmcl.2005.07.024
		14	8625	54	None	-1	18	Human	9.2	pKi	=	9.2	Binding	Affinity towards cloned human 5-hydroxytryptamine 1D receptorAffinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/j.bmcl.2005.07.024
		CHEMBL15928	8625	54	None	-1	18	Human	9.2	pKi	=	9.2	Binding	Affinity towards cloned human 5-hydroxytryptamine 1D receptorAffinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/j.bmcl.2005.07.024
		11402988	65984	0	None	32	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	270	4	1	2	4.0	CN(C)CCc1c[nH]c2ccc(-c3cccs3)cc12	10.1016/s0960-894x(00)00133-5
		CHEMBL170192	65984	0	None	32	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	270	4	1	2	4.0	CN(C)CCc1c[nH]c2ccc(-c3cccs3)cc12	10.1016/s0960-894x(00)00133-5
		44342993	17782	0	None	4	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	480	4	2	2	6.7	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4cccc5ccccc45)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL117397	17782	0	None	4	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	480	4	2	2	6.7	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4cccc5ccccc45)CC3)cc12	10.1016/s0960-894x(03)00779-0
		3658	10879	53	None	4	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1016/j.bmcl.2004.06.085
		517	10879	53	None	4	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1016/j.bmcl.2004.06.085
		5709	10879	53	None	4	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1016/j.bmcl.2004.06.085
		CHEMBL312448	10879	53	None	4	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1016/j.bmcl.2004.06.085
		DB06694	10879	53	None	4	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1016/j.bmcl.2004.06.085
		3658	10879	53	None	4	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1021/jm970513p
		517	10879	53	None	4	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1021/jm970513p
		5709	10879	53	None	4	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1021/jm970513p
		CHEMBL312448	10879	53	None	4	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1021/jm970513p
		DB06694	10879	53	None	4	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1021/jm970513p
		44351692	26228	6	None	2	3	Human	9.2	pKi	=	9.2	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	242	2	1	3	2.3	COc1ccc2ccc(N3CCNCC3)cc2c1	10.1021/jm9703552
		CHEMBL129661	26228	6	None	2	3	Human	9.2	pKi	=	9.2	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	242	2	1	3	2.3	COc1ccc2ccc(N3CCNCC3)cc2c1	10.1021/jm9703552
		44351656	123876	0	None	-5	3	Human	9.1	pKi	=	9.1	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	499	6	2	7	4.3	COc1ccc(NC(=O)c2ccc(-c3ccc(C4=NC(C)ON4)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm9703552
		CHEMBL339308	123876	0	None	-5	3	Human	9.1	pKi	=	9.1	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	499	6	2	7	4.3	COc1ccc(NC(=O)c2ccc(-c3ccc(C4=NC(C)ON4)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm9703552
		44342727	16943	0	None	18	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	465	6	1	4	4.3	COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		CHEMBL115941	16943	0	None	18	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	465	6	1	4	4.3	COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		2869	10924	89	None	-2	7	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1016/s0960-894x(98)00090-0
		60	10924	89	None	-2	7	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1016/s0960-894x(98)00090-0
		60857	10924	89	None	-2	7	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1016/s0960-894x(98)00090-0
		CHEMBL1185	10924	89	None	-2	7	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1016/s0960-894x(98)00090-0
		DB00315	10924	89	None	-2	7	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1016/s0960-894x(98)00090-0
		10174078	183673	0	None	2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	472	7	1	5	5.1	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@H](C)N[C@H](C)C5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL461670	183673	0	None	2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	472	7	1	5	5.1	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@H](C)N[C@H](C)C5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		10287730	10309	40	None	251	12	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
		77	10309	40	None	251	12	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
		CHEMBL425190	10309	40	None	251	12	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
		11328382	98758	0	None	3	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL241503	98758	0	None	3	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2006.11.031
		10287730	10309	40	None	251	12	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm8001444
		77	10309	40	None	251	12	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm8001444
		CHEMBL425190	10309	40	None	251	12	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm8001444
		44404229	77261	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	397	2	0	5	3.1	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C#N)cc2)CC4)CC1	10.1016/j.bmcl.2005.06.042
		CHEMBL194647	77261	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	397	2	0	5	3.1	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C#N)cc2)CC4)CC1	10.1016/j.bmcl.2005.06.042
		10385855	21197	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		CHEMBL120055	21197	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		CHEMBL321818	21197	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		44342969	17300	0	None	21	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	449	5	1	3	4.6	Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		CHEMBL116876	17300	0	None	21	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	449	5	1	3	4.6	Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1	10.1016/s0960-894x(03)00779-0
		1043	8363	14	None	-23	29	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/jm990550b
		149	8363	14	None	-23	29	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/jm990550b
		8223	8363	14	None	-23	29	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/jm990550b
		CHEMBL442	8363	14	None	-23	29	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/jm990550b
		DB00696	8363	14	None	-23	29	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/jm990550b
		10477386	121868	1	None	40	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	423	7	2	6	2.3	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL334323	121868	1	None	40	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	423	7	2	6	2.3	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		10385855	21197	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
		CHEMBL120055	21197	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
		CHEMBL321818	21197	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
		10096890	116933	0	None	26	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	485	5	1	3	5.4	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(S(=O)(=O)c4cccc5ccccc45)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL323666	116933	0	None	26	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	485	5	1	3	5.4	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(S(=O)(=O)c4cccc5ccccc45)CC3)cc12	10.1016/s0960-894x(03)00779-0
		10672840	85552	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	494	5	0	5	4.5	CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6ccccc56)CC4)cc23)CC1	10.1021/jm9703552
		CHEMBL2112661	85552	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	494	5	0	5	4.5	CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6ccccc56)CC4)cc23)CC1	10.1021/jm9703552
		9832057	59089	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	692	16	2	6	4.8	CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12	10.1021/jm7011722
		CHEMBL158941	59089	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	692	16	2	6	4.8	CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12	10.1021/jm7011722
		9832057	59089	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	692	16	2	6	4.8	CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12	10.1016/s0960-894x(98)00090-0
		CHEMBL158941	59089	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	692	16	2	6	4.8	CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12	10.1016/s0960-894x(98)00090-0
		16	9033	8	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1016/j.bmcl.2003.09.025
		9847194	9033	8	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1016/j.bmcl.2003.09.025
		CHEMBL313714	9033	8	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1016/j.bmcl.2003.09.025
		3228	9920	23	None	186	7	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC	10.1021/jm7011722
		9909448	9920	23	None	186	7	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC	10.1021/jm7011722
		CHEMBL71838	9920	23	None	186	7	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC	10.1021/jm7011722
		24881752	178538	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	638	14	4	4	8.4	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL446745	178538	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	638	14	4	4	8.4	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		24881202	179365	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	596	11	4	4	7.2	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL448902	179365	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	596	11	4	4	7.2	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		44431536	94096	0	None	23	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	454	5	1	5	4.0	C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		CHEMBL233210	94096	0	None	23	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	454	5	1	5	4.0	C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		3228	9920	23	None	186	7	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]serotonin from recombinant human 5-HT1D receptor expressed in HEK293 cells incubated for 1 hr by competitive radioligand binding assay basedDisplacement of [3H]serotonin from recombinant human 5-HT1D receptor expressed in HEK293 cells incubated for 1 hr by competitive radioligand binding assay based	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC	10.1016/j.ejmech.2020.113073
		9909448	9920	23	None	186	7	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]serotonin from recombinant human 5-HT1D receptor expressed in HEK293 cells incubated for 1 hr by competitive radioligand binding assay basedDisplacement of [3H]serotonin from recombinant human 5-HT1D receptor expressed in HEK293 cells incubated for 1 hr by competitive radioligand binding assay based	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC	10.1016/j.ejmech.2020.113073
		CHEMBL71838	9920	23	None	186	7	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]serotonin from recombinant human 5-HT1D receptor expressed in HEK293 cells incubated for 1 hr by competitive radioligand binding assay basedDisplacement of [3H]serotonin from recombinant human 5-HT1D receptor expressed in HEK293 cells incubated for 1 hr by competitive radioligand binding assay based	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC	10.1016/j.ejmech.2020.113073
		11740144	69806	0	None	6	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	374	8	1	2	5.2	CCCN(CCCc1ccccc1)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL1788197	69806	0	None	6	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	374	8	1	2	5.2	CCCN(CCCc1ccccc1)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		3228	9920	23	None	186	7	Human	9.1	pKi	=	9.1	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC	10.1021/jm980137o
		9909448	9920	23	None	186	7	Human	9.1	pKi	=	9.1	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC	10.1021/jm980137o
		CHEMBL71838	9920	23	None	186	7	Human	9.1	pKi	=	9.1	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC	10.1021/jm980137o
		2869	10924	89	None	-2	7	Human	9.0	pKi	=	9.0	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a020
		60	10924	89	None	-2	7	Human	9.0	pKi	=	9.0	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a020
		60857	10924	89	None	-2	7	Human	9.0	pKi	=	9.0	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a020
		CHEMBL1185	10924	89	None	-2	7	Human	9.0	pKi	=	9.0	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a020
		DB00315	10924	89	None	-2	7	Human	9.0	pKi	=	9.0	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a020
		10408880	21008	0	None	25	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	403	6	2	5	2.3	N#Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		CHEMBL119927	21008	0	None	25	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	403	6	2	5	2.3	N#Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		10250834	22207	1	None	83	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	407	7	3	5	1.9	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(CN)cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL121499	22207	1	None	83	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	407	7	3	5	1.9	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(CN)cc4)CC3)cc12	10.1021/jm00018a020
		10048222	60771	0	None	12	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	428	6	2	4	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4cccc5ccccc45)CC3)cc12	10.1016/0960-894X(95)00091-7
		CHEMBL160581	60771	0	None	12	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	428	6	2	4	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4cccc5ccccc45)CC3)cc12	10.1016/0960-894X(95)00091-7
		24881689	176911	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	554	8	4	4	6.0	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL444404	176911	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	554	8	4	4	6.0	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		24881203	180010	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	624	13	4	4	8.0	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL452387	180010	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	624	13	4	4	8.0	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		10131024	182940	16	None	47	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	242	3	1	1	3.4	CCc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1016/s0960-894x(00)00322-x
		CHEMBL45929	182940	16	None	47	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	242	3	1	1	3.4	CCc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1016/s0960-894x(00)00322-x
		75	10287	7	None	3	3	Human	9.0	pKi	=	9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	10.1016/j.bmcl.2005.07.085
		9870500	10287	7	None	3	3	Human	9.0	pKi	=	9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	10.1016/j.bmcl.2005.07.085
		CHEMBL191971	10287	7	None	3	3	Human	9.0	pKi	=	9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	10.1016/j.bmcl.2005.07.085
		10458087	17540	0	None	64	2	Human	9.0	pKi	=	9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	485	9	3	6	1.4	CS(=O)(=O)NCc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL117157	17540	0	None	64	2	Human	9.0	pKi	=	9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	485	9	3	6	1.4	CS(=O)(=O)NCc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		44581260	182371	0	None	5	3	Human	9.0	pKi	=	9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	472	7	1	5	5.1	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@@H](C)NC[C@@H]5C)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL457982	182371	0	None	5	3	Human	9.0	pKi	=	9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	472	7	1	5	5.1	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@@H](C)NC[C@@H]5C)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		10127424	182834	0	None	1	3	Human	9.0	pKi	=	9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	443	7	0	4	5.9	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCCC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL459061	182834	0	None	1	3	Human	9.0	pKi	=	9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	443	7	0	4	5.9	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCCC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		10288132	183796	0	None	7	3	Human	9.0	pKi	=	9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	437	7	0	4	5.9	Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccncc5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL462916	183796	0	None	7	3	Human	9.0	pKi	=	9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	437	7	0	4	5.9	Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccncc5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		10127673	194611	0	None	6	3	Human	9.0	pKi	=	9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	460	9	1	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)CN(C)C)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL496098	194611	0	None	6	3	Human	9.0	pKi	=	9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	460	9	1	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)CN(C)C)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		10238565	197705	0	None	3	3	Human	9.0	pKi	=	9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	458	7	1	5	4.7	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@@H](C)C5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL518545	197705	0	None	3	3	Human	9.0	pKi	=	9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	458	7	1	5	4.7	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@@H](C)C5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		44443094	100746	0	None	7	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	460	7	0	6	3.5	CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21	10.1016/j.bmcl.2007.06.078
		CHEMBL248458	100746	0	None	7	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	460	7	0	6	3.5	CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21	10.1016/j.bmcl.2007.06.078
		24881618	195566	0	None	125	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	798	16	4	4	11.2	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL505750	195566	0	None	125	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	798	16	4	4	11.2	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		24865538	194358	0	None	70	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	361	6	0	4	3.7	Cc1ccc2c(OCCN3CCN(Cc4ccccc4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL494631	194358	0	None	70	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	361	6	0	4	3.7	Cc1ccc2c(OCCN3CCN(Cc4ccccc4)CC3)cccc2n1	10.1021/jm8001444
		10127673	194611	0	None	6	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	460	9	1	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)CN(C)C)c4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL496098	194611	0	None	6	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	460	9	1	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)CN(C)C)c4)CC3)cccc2n1	10.1021/jm8001444
		44431537	152019	0	None	15	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	440	5	1	5	3.6	N#Cc1ccc2c(N3CCN(CC[C@@H]4OCCc5cc(C(N)=O)ccc54)CC3)cccc2c1	10.1016/j.bmcl.2007.03.101
		CHEMBL391273	152019	0	None	15	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	440	5	1	5	3.6	N#Cc1ccc2c(N3CCN(CC[C@@H]4OCCc5cc(C(N)=O)ccc54)CC3)cccc2c1	10.1016/j.bmcl.2007.03.101
		44404268	78928	0	None	-1	3	Human	9.0	pKi	=	9	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	517	4	0	7	4.3	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		CHEMBL197947	78928	0	None	-1	3	Human	9.0	pKi	=	9	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	517	4	0	7	4.3	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		9837525	109932	1	None	33	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	230	3	1	2	3.0	Cc1cc(C(C)C)cc(C)c1CC1=NCCN1	10.1021/jm970513p
		CHEMBL308042	109932	1	None	33	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	230	3	1	2	3.0	Cc1cc(C(C)C)cc(C)c1CC1=NCCN1	10.1021/jm970513p
		15340760	50225	18	None	-	1	Human	9.0	pKi	=	9.0	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	202	3	2	1	2.8	CC(C)c1ccc2[nH]cc(CCN)c2c1	10.1021/jm9805945
		CHEMBL150798	50225	18	None	-	1	Human	9.0	pKi	=	9.0	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	202	3	2	1	2.8	CC(C)c1ccc2[nH]cc(CCN)c2c1	10.1021/jm9805945
		10456474	21311	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	451	9	2	6	3.1	NCCc1c[nH]c2ccc(OCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL120272	21311	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	451	9	2	6	3.1	NCCc1c[nH]c2ccc(OCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		9999722	170961	0	None	16	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL421064	170961	0	None	16	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1021/jm00018a020
		9999722	170961	0	None	16	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1016/0960-894X(95)00091-7
		CHEMBL421064	170961	0	None	16	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1016/0960-894X(95)00091-7
		2543	10479	68	None	-1	32	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm7011722
		5358	10479	68	None	-1	32	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm7011722
		54	10479	68	None	-1	32	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm7011722
		CHEMBL128	10479	68	None	-1	32	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm7011722
		DB00669	10479	68	None	-1	32	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm7011722
		44279550	106581	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	650	8	0	8	3.6	CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(C(=O)COc5ccc6cccc(N7CCN(C)CC7)c6c5)CC4)cc23)CC1	10.1016/s0960-894x(98)00222-4
		CHEMBL285402	106581	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	650	8	0	8	3.6	CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(C(=O)COc5ccc6cccc(N7CCN(C)CC7)c6c5)CC4)cc23)CC1	10.1016/s0960-894x(98)00222-4
		107780	8625	54	None	-1	18	Human	8.9	pKi	=	8.9	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alphaBinding affinity against 5-hydroxytryptamine 1D receptor alpha	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm00041a001
		14	8625	54	None	-1	18	Human	8.9	pKi	=	8.9	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alphaBinding affinity against 5-hydroxytryptamine 1D receptor alpha	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm00041a001
		CHEMBL15928	8625	54	None	-1	18	Human	8.9	pKi	=	8.9	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alphaBinding affinity against 5-hydroxytryptamine 1D receptor alpha	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm00041a001
		44581603	182837	0	None	5	3	Human	8.9	pKi	=	8.9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	443	7	1	4	5.3	Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCNCC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL459067	182837	0	None	5	3	Human	8.9	pKi	=	8.9	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	443	7	1	4	5.3	Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCNCC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		44443132	176263	0	None	1	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	478	7	0	6	3.6	CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)c(F)c21	10.1016/j.bmcl.2007.06.078
		CHEMBL443060	176263	0	None	1	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	478	7	0	6	3.6	CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)c(F)c21	10.1016/j.bmcl.2007.06.078
		24865542	194906	0	None	5	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	445	8	1	4	5.5	Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL498355	194906	0	None	5	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	445	8	1	4	5.5	Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1	10.1021/jm8001444
		24865543	194907	0	None	19	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	431	7	0	4	4.9	CC(=O)N(C)c1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		CHEMBL498356	194907	0	None	19	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	431	7	0	4	4.9	CC(=O)N(C)c1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		44404249	147139	0	None	-3	3	Human	8.9	pKi	=	8.9	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	412	2	0	6	2.8	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cnn3ccccc23)CC4)CC1	10.1016/j.bmcl.2005.06.042
		CHEMBL380812	147139	0	None	-3	3	Human	8.9	pKi	=	8.9	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	412	2	0	6	2.8	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cnn3ccccc23)CC4)CC1	10.1016/j.bmcl.2005.06.042
		9805881	121664	0	None	41	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	497	8	3	5	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(NC(=O)c5ccccc5)cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL334193	121664	0	None	41	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	497	8	3	5	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(NC(=O)c5ccccc5)cc4)CC3)cc12	10.1021/jm00018a020
		10324625	119680	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	527	12	3	6	3.3	CS(=O)(=O)Nc1ccc(N2CCN(C(=O)CCCCCOc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL331037	119680	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	527	12	3	6	3.3	CS(=O)(=O)Nc1ccc(N2CCN(C(=O)CCCCCOc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		10003116	17195	0	None	36	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	435	9	3	5	3.1	NCCc1c[nH]c2ccc(OCCCCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL116314	17195	0	None	36	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	435	9	3	5	3.1	NCCc1c[nH]c2ccc(OCCCCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		10324625	119680	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	527	12	3	6	3.3	CS(=O)(=O)Nc1ccc(N2CCN(C(=O)CCCCCOc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL331037	119680	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	527	12	3	6	3.3	CS(=O)(=O)Nc1ccc(N2CCN(C(=O)CCCCCOc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		10003116	17195	0	None	36	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	435	9	3	5	3.1	NCCc1c[nH]c2ccc(OCCCCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL116314	17195	0	None	36	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	435	9	3	5	3.1	NCCc1c[nH]c2ccc(OCCCCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		10365683	119855	0	None	1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	435	7	3	5	2.4	CC(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL331240	119855	0	None	1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	435	7	3	5	2.4	CC(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		15549970	126015	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	265	4	0	3	3.3	CN(C)CCn1ccc2ccc(-c3cccnc3)cc21	10.1016/j.bmcl.2003.09.025
		CHEMBL343492	126015	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	265	4	0	3	3.3	CN(C)CCn1ccc2ccc(-c3cccnc3)cc21	10.1016/j.bmcl.2003.09.025
		24881753	143980	0	None	-14	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	666	16	4	4	9.1	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL374973	143980	0	None	-14	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	666	16	4	4	9.1	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		24882268	179336	0	None	11	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	788	15	4	6	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL448555	179336	0	None	11	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	788	15	4	6	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		10848041	16146	1	None	1	3	Human	8.8	pKi	=	8.8	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	246	7	2	2	3.2	CCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		CHEMBL111376	16146	1	None	1	3	Human	8.8	pKi	=	8.8	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	246	7	2	2	3.2	CCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		10174088	196277	0	None	1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	473	7	0	5	5.5	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@H](C)O[C@H](C)C5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL513955	196277	0	None	1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	473	7	0	5	5.5	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@H](C)O[C@H](C)C5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		10296414	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1021/jm049039v
		76	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1021/jm049039v
		CHEMBL183460	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1021/jm049039v
		10150658	75420	1	None	158	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	392	6	2	6	3.0	Cc1ccc2c(OCCN3CCN(Cc4ccc(O)c(N)c4)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL191895	75420	1	None	158	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	392	6	2	6	3.0	Cc1ccc2c(OCCN3CCN(Cc4ccc(O)c(N)c4)CC3)cccc2n1	10.1021/jm049039v
		10296414	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
		76	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
		CHEMBL183460	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
		49850771	63172	0	None	1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	428	5	0	5	3.6	Cc1ccc2c(N3CCN(CCc4cccc(N5C(=O)CCC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		CHEMBL1631544	63172	0	None	1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells	ChEMBL	428	5	0	5	3.6	Cc1ccc2c(N3CCN(CCc4cccc(N5C(=O)CCC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
		10296414	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2007.06.078
		76	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2007.06.078
		CHEMBL183460	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2007.06.078
		22326688	100372	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	459	7	0	5	4.6	CCN1C(=O)COc2ccc(CC3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21	10.1016/j.bmcl.2007.06.078
		CHEMBL246598	100372	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	459	7	0	5	4.6	CCN1C(=O)COc2ccc(CC3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21	10.1016/j.bmcl.2007.06.078
		44580740	194541	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	416	4	1	5	3.6	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@@H](C)C3)cccc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL495703	194541	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	416	4	1	5	3.6	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@@H](C)C3)cccc2n1	10.1016/j.bmcl.2008.08.084
		10296414	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2008.08.110
		76	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2008.08.110
		CHEMBL183460	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2008.08.110
		10296414	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1021/jm8001444
		76	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1021/jm8001444
		CHEMBL183460	10304	15	None	-1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1021/jm8001444
		24865726	194435	0	None	7	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	467	8	0	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4cccc(N(C)S(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL495046	194435	0	None	7	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	467	8	0	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4cccc(N(C)S(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		24865724	194743	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	445	8	0	4	5.3	CCN(C(C)=O)c1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		CHEMBL497127	194743	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	445	8	0	4	5.3	CCN(C(C)=O)c1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		24865727	199892	0	None	5	11	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	479	7	0	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL522708	199892	0	None	5	11	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	479	7	0	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
		10613373	118082	1	None	1	3	Human	8.8	pKi	=	8.8	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	288	10	2	2	4.4	CCCCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		CHEMBL326667	118082	1	None	1	3	Human	8.8	pKi	=	8.8	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	288	10	2	2	4.4	CCCCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		10060289	67089	1	None	-1	4	Human	8.8	pKi	=	8.8	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	242	2	1	2	2.4	CN(C)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL1744040	67089	1	None	-1	4	Human	8.8	pKi	=	8.8	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	242	2	1	2	2.4	CN(C)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		10340549	121604	0	None	275	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	393	6	3	5	2.0	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL334159	121604	0	None	275	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	393	6	3	5	2.0	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		10198700	127574	3	None	18	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	242	3	2	2	3.4	NCCc1c[nH]c2ccc(-c3cccs3)cc12	10.1016/s0960-894x(00)00133-5
		CHEMBL355517	127574	3	None	18	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	242	3	2	2	3.4	NCCc1c[nH]c2ccc(-c3cccs3)cc12	10.1016/s0960-894x(00)00133-5
		9805881	121664	0	None	41	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	497	8	3	5	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(NC(=O)c5ccccc5)cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL334193	121664	0	None	41	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	497	8	3	5	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(NC(=O)c5ccccc5)cc4)CC3)cc12	10.1021/jm00018a020
		24881204	195201	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	680	17	4	4	9.5	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL502138	195201	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	680	17	4	4	9.5	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		5	6927	72	None	-6	53	Human	8.8	pKi	=	8.8	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950498t
		5202	6927	72	None	-6	53	Human	8.8	pKi	=	8.8	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950498t
		CHEMBL39	6927	72	None	-6	53	Human	8.8	pKi	=	8.8	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950498t
		DB08839	6927	72	None	-6	53	Human	8.8	pKi	=	8.8	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950498t
		10799383	50873	1	None	-	1	Human	8.8	pKi	=	8.8	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	228	3	2	1	3.3	NCCc1c[nH]c2ccc(C3CCCC3)cc12	10.1021/jm9805945
		CHEMBL151502	50873	1	None	-	1	Human	8.8	pKi	=	8.8	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	228	3	2	1	3.3	NCCc1c[nH]c2ccc(C3CCCC3)cc12	10.1021/jm9805945
		44279889	109971	0	None	1	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	510	7	0	6	5.0	CN1CCN(c2cccc3ccc(OCCOc4ccc5cccc(N6CCN(C)CC6)c5c4)cc23)CC1	10.1016/s0960-894x(98)00222-4
		CHEMBL30831	109971	0	None	1	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	510	7	0	6	5.0	CN1CCN(c2cccc3ccc(OCCOc4ccc5cccc(N6CCN(C)CC6)c5c4)cc23)CC1	10.1016/s0960-894x(98)00222-4
		10253939	117163	0	None	7	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	465	10	2	6	3.5	NCCc1c[nH]c2ccc(OCCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL324289	117163	0	None	7	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	465	10	2	6	3.5	NCCc1c[nH]c2ccc(OCCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		10069977	120283	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	407	7	3	5	1.9	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4CN)CC3)cc12	10.1021/jm00018a020
		CHEMBL332063	120283	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	407	7	3	5	1.9	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4CN)CC3)cc12	10.1021/jm00018a020
		44383737	139299	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	340	6	1	3	4.6	COC[C@@H]1CCCN1CCc1c[nH]c2ccc(-c3cccs3)cc12	10.1016/s0960-894x(00)00133-5
		CHEMBL369798	139299	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	340	6	1	3	4.6	COC[C@@H]1CCCN1CCc1c[nH]c2ccc(-c3cccs3)cc12	10.1016/s0960-894x(00)00133-5
		10458088	21377	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	485	9	3	6	1.4	CS(=O)(=O)NCc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		CHEMBL120480	21377	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	485	9	3	6	1.4	CS(=O)(=O)NCc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		122197405	140254	0	None	47	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	440	5	1	5	4.0	C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@H]1OCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		CHEMBL3706925	140254	0	None	47	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	440	5	1	5	4.0	C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@H]1OCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		9983460	19159	0	None	58	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	500	9	3	6	1.6	CN(C)S(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL118563	19159	0	None	58	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	500	9	3	6	1.6	CN(C)S(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL1203216	19159	0	None	58	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	500	9	3	6	1.6	CN(C)S(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		10791125	25733	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	486	5	0	5	4.2	Cc1cc(C)c(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c(C)c1	10.1021/jm9703552
		CHEMBL128699	25733	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	486	5	0	5	4.2	Cc1cc(C)c(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c(C)c1	10.1021/jm9703552
		10310285	196704	0	None	2	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	437	7	0	4	5.9	Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5cccnc5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL516997	196704	0	None	2	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	437	7	0	4	5.9	Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5cccnc5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		11270107	75021	0	None	19	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	420	7	0	6	4.0	Cc1ccc2c(OCCN3CCN(Cc4ccc(C)c([N+](=O)[O-])c4)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL191605	75021	0	None	19	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	420	7	0	6	4.0	Cc1ccc2c(OCCN3CCN(Cc4ccc(C)c([N+](=O)[O-])c4)CC3)cccc2n1	10.1021/jm049039v
		44443095	100373	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	474	8	0	6	3.9	CCCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21	10.1016/j.bmcl.2007.06.078
		CHEMBL246599	100373	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	474	8	0	6	3.9	CCCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21	10.1016/j.bmcl.2007.06.078
		44443101	100734	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	536	9	0	6	4.7	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(CCc4ccccc4)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		CHEMBL248407	100734	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	536	9	0	6	4.7	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(CCc4ccccc4)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		10216873	194579	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	443	7	0	4	5.0	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCC5=O)c4)CC3)cccc2n1	10.1021/jm8001444
		CHEMBL495895	194579	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	443	7	0	4	5.0	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCC5=O)c4)CC3)cccc2n1	10.1021/jm8001444
		75	10287	7	None	3	3	Human	8.7	pKi	=	8.7	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	10.1016/j.bmcl.2005.06.042
		9870500	10287	7	None	3	3	Human	8.7	pKi	=	8.7	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	10.1016/j.bmcl.2005.06.042
		CHEMBL191971	10287	7	None	3	3	Human	8.7	pKi	=	8.7	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	10.1016/j.bmcl.2005.06.042
		15512338	214454	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	407	3	2	4	4.2	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc(Cl)c1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL95387	214454	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	407	3	2	4	4.2	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc(Cl)c1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		10547384	214975	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	373	3	2	4	3.5	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc(Cl)c1)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL98434	214975	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	373	3	2	4	3.5	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc(Cl)c1)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		10238763	182473	0	None	-1	3	Human	8.0	pKi	=	8	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	472	7	0	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)C(=O)C5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL458200	182473	0	None	-1	3	Human	8.0	pKi	=	8	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	472	7	0	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)C(=O)C5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		44400359	75460	0	None	6	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	6	0	7	3.0	Cc1ccc2c(OCCN3CCN(CN4C=CC5=CC(=O)CC=C5O4)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL192176	75460	0	None	6	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	432	6	0	7	3.0	Cc1ccc2c(OCCN3CCN(CN4C=CC5=CC(=O)CC=C5O4)CC3)cccc2n1	10.1021/jm049039v
		11464355	134011	0	None	39	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	422	7	1	7	3.4	Cc1ccc2c(OCCN3CCN(Cc4ccc(O)c([N+](=O)[O-])c4)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL365810	134011	0	None	39	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	422	7	1	7	3.4	Cc1ccc2c(OCCN3CCN(Cc4ccc(O)c([N+](=O)[O-])c4)CC3)cccc2n1	10.1021/jm049039v
		10159927	100745	0	None	-1	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	432	6	1	6	3.1	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		CHEMBL248457	100745	0	None	-1	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	432	6	1	6	3.1	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		10024936	191742	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	416	5	1	5	3.6	Cc1ccc2c(N3CCN(CCCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL485395	191742	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	416	5	1	5	3.6	Cc1ccc2c(N3CCN(CCCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		44431535	94802	0	None	70	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	433	5	1	4	3.9	NC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(c2ccc3cc(F)ccc3c2)CC1	10.1016/j.bmcl.2007.03.101
		CHEMBL234449	94802	0	None	70	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	433	5	1	4	3.9	NC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(c2ccc3cc(F)ccc3c2)CC1	10.1016/j.bmcl.2007.03.101
		10068933	110578	0	None	3	4	Guinea pig	8.0	pKi	=	8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	389	8	1	4	4.5	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1CCCN(C)C	10.1021/jm00041a001
		CHEMBL309021	110578	0	None	3	4	Guinea pig	8.0	pKi	=	8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	389	8	1	4	4.5	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1CCCN(C)C	10.1021/jm00041a001
		17947861	78225	1	None	-1	3	Human	8.0	pKi	=	8	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	444	2	0	6	2.9	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cnn(C)c2C(F)(F)F)CC4)CC1	10.1016/j.bmcl.2005.06.042
		CHEMBL196140	78225	1	None	-1	3	Human	8.0	pKi	=	8	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	444	2	0	6	2.9	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cnn(C)c2C(F)(F)F)CC4)CC1	10.1016/j.bmcl.2005.06.042
		10733010	125948	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	300	7	1	1	5.1	CCCN(CCC)CCc1c[nH]c2ccc(C(C)(C)C)cc12	10.1021/jm9805945
		CHEMBL343025	125948	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	300	7	1	1	5.1	CCCN(CCC)CCc1c[nH]c2ccc(C(C)(C)C)cc12	10.1021/jm9805945
		7694	10284	36	None	-50	4	Human	7.0	pKi	=	7	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	426	5	2	3	4.8	N#Cc1ccc2c(c1)CN(CC2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1cc2c([nH]1)cccc2	10.1021/jm000090i
		9910352	10284	36	None	-50	4	Human	7.0	pKi	=	7	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	426	5	2	3	4.8	N#Cc1ccc2c(c1)CN(CC2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1cc2c([nH]1)cccc2	10.1021/jm000090i
		CHEMBL2219578	10284	36	None	-50	4	Human	7.0	pKi	=	7	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	426	5	2	3	4.8	N#Cc1ccc2c(c1)CN(CC2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1cc2c([nH]1)cccc2	10.1021/jm000090i
		10597855	91164	0	None	-79	4	Human	7.0	pKi	=	7	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	413	6	1	3	4.7	N#Cc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)CC2	10.1021/jm000090i
		CHEMBL2113350	91164	0	None	-79	4	Human	7.0	pKi	=	7	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	413	6	1	3	4.7	N#Cc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)CC2	10.1021/jm000090i
		CHEMBL2219579	91164	0	None	-79	4	Human	7.0	pKi	=	7	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	413	6	1	3	4.7	N#Cc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)CC2	10.1021/jm000090i
		12103248	91170	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	437	5	1	3	5.4	N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)C2	10.1021/jm000090i
		CHEMBL2113348	91170	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	437	5	1	3	5.4	N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)C2	10.1021/jm000090i
		CHEMBL2219587	91170	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	437	5	1	3	5.4	N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)C2	10.1021/jm000090i
		44402877	77906	0	None	-31	3	Human	7.0	pKi	=	7	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	520	4	0	5	6.0	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL195497	77906	0	None	-31	3	Human	7.0	pKi	=	7	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	520	4	0	5	6.0	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2	10.1016/j.bmcl.2005.07.085
		44402879	78183	0	None	-50	2	Human	7.0	pKi	=	7	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	445	4	0	4	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(Cl)c1F)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL195898	78183	0	None	-50	2	Human	7.0	pKi	=	7	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	445	4	0	4	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(Cl)c1F)CC2	10.1016/j.bmcl.2005.07.085
		10370874	89370	0	None	-31	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	484	9	1	6	5.8	COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1CCCN(C)C	10.1021/jm970457s
		CHEMBL21790	89370	0	None	-31	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	484	9	1	6	5.8	COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1CCCN(C)C	10.1021/jm970457s
		50878551	97520	61	None	-3	18	Human	7.0	pKi	=	7	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL2391541	97520	61	None	-3	18	Human	7.0	pKi	=	7	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		242	7258	124	None	-41	51	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		34	7258	124	None	-41	51	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		60795	7258	124	None	-41	51	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		CHEMBL1112	7258	124	None	-41	51	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		DB01238	7258	124	None	-41	51	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		11178830	154905	0	None	-63	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL393539	154905	0	None	-63	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		9913554	107769	0	None	-125	14	Human	7.0	pKi	=	7	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
		CHEMBL29433	107769	0	None	-125	14	Human	7.0	pKi	=	7	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
		2389	10104	118	None	-72	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		5073	10104	118	None	-72	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		96	10104	118	None	-72	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		CHEMBL85	10104	118	None	-72	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		DB00734	10104	118	None	-72	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		11067619	11907	0	None	-138	4	Human	6.0	pKi	=	6	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	334	3	2	3	3.6	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4)nc23)CC1	10.1021/jm030020m
		CHEMBL105743	11907	0	None	-138	4	Human	6.0	pKi	=	6	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	334	3	2	3	3.6	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4)nc23)CC1	10.1021/jm030020m
		10738913	211742	0	None	-1	5	Human	5.0	pKi	=	5	Binding	Affinity pKi for 5-hydroxytryptamine 1D receptor was measured in calf caudate homogenateAffinity pKi for 5-hydroxytryptamine 1D receptor was measured in calf caudate homogenate	ChEMBL	386	8	2	5	1.5	CCOC(=O)c1[nH]c2ccc(CCN3C(=O)CNC3=O)cc2c1CCN(C)C	10.1021/jm9605849
		CHEMBL76480	211742	0	None	-1	5	Human	5.0	pKi	=	5	Binding	Affinity pKi for 5-hydroxytryptamine 1D receptor was measured in calf caudate homogenateAffinity pKi for 5-hydroxytryptamine 1D receptor was measured in calf caudate homogenate	ChEMBL	386	8	2	5	1.5	CCOC(=O)c1[nH]c2ccc(CCN3C(=O)CNC3=O)cc2c1CCN(C)C	10.1021/jm9605849
		145986752	174055	0	None	-23	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
		CHEMBL4293307	174055	0	None	-23	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
		56593934	72469	0	None	-2630	8	Human	5.0	pKi	=	5	Binding	Inhibition of human 5-HT1D receptorInhibition of human 5-HT1D receptor	ChEMBL	383	3	2	4	1.7	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC2(C=N1)CCNCC2	10.1021/jm200466r
		CHEMBL1834350	72469	0	None	-2630	8	Human	5.0	pKi	=	5	Binding	Inhibition of human 5-HT1D receptorInhibition of human 5-HT1D receptor	ChEMBL	383	3	2	4	1.7	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC2(C=N1)CCNCC2	10.1021/jm200466r
		44404396	78232	0	None	-5	5	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	427	4	1	5	2.9	COc1ccc(NC(=O)N2CCN(c3ccccc3F)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL196169	78232	0	None	-5	5	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	427	4	1	5	2.9	COc1ccc(NC(=O)N2CCN(c3ccccc3F)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		10774567	110599	0	None	5	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	204	2	2	3	1.6	Cc1ccc(O)c(C)c1CC1=NCCN1	10.1021/jm970513p
		CHEMBL309162	110599	0	None	5	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	204	2	2	3	1.6	Cc1ccc(O)c(C)c1CC1=NCCN1	10.1021/jm970513p
		44269078	105373	7	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	202	1	1	2	2.3	CC(C)(C)c1ccc(C2=NCCN2)cc1	10.1016/j.bmcl.2004.06.085
		CHEMBL276868	105373	7	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	202	1	1	2	2.3	CC(C)(C)c1ccc(C2=NCCN2)cc1	10.1016/j.bmcl.2004.06.085
		10130620	110426	3	None	64	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	216	2	1	2	2.5	CC(C)(C)c1ccc(CC2=NCCN2)cc1	10.1021/jm970513p
		CHEMBL308727	110426	3	None	64	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	216	2	1	2	2.5	CC(C)(C)c1ccc(CC2=NCCN2)cc1	10.1021/jm970513p
		10478367	78445	0	None	-19	7	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL196370	78445	0	None	-19	7	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL430500	78445	0	None	-19	7	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		52899	104029	34	None	-12	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	204	3	2	2	2.0	COc1ccc2[nH]c(C)c(CCN)c2c1	10.1021/jm00164a046
		CHEMBL268800	104029	34	None	-12	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	204	3	2	2	2.0	COc1ccc2[nH]c(C)c(CCN)c2c1	10.1021/jm00164a046
		44582675	196480	0	None	-18	15	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL515472	196480	0	None	-18	15	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		145980271	173271	0	None	-2	16	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4278465	173271	0	None	-2	16	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		9972838	211082	0	None	-7	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	312	6	1	2	4.4	CCCN(CCC)C1CCc2ccc3[nH]cc(C(C)=O)c3c2C1	10.1021/jm00012a021
		CHEMBL71395	211082	0	None	-7	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	312	6	1	2	4.4	CCCN(CCC)C1CCc2ccc3[nH]cc(C(C)=O)c3c2C1	10.1021/jm00012a021
		10541847	109078	0	None	3	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	294	5	1	3	3.4	Cc1ccc(CC2=NCCN2)c(C)c1OCc1ccccc1	10.1021/jm970513p
		CHEMBL303441	109078	0	None	3	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	294	5	1	3	3.4	Cc1ccc(CC2=NCCN2)c(C)c1OCc1ccccc1	10.1021/jm970513p
		44456033	162346	3	None	-851	8	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor	ChEMBL	195	0	2	3	2.0	C[C@@H]1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL404372	162346	3	None	-851	8	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor	ChEMBL	195	0	2	3	2.0	C[C@@H]1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		10517352	14400	0	None	-5	2	Human	6.0	pKi	=	6.0	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	286	6	2	2	3.9	CCCCCCOc1ccc2[nH]c3c(c2c1)CC(N)CC3	10.1021/jm950498t
		CHEMBL108818	14400	0	None	-5	2	Human	6.0	pKi	=	6.0	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	286	6	2	2	3.9	CCCCCCOc1ccc2[nH]c3c(c2c1)CC(N)CC3	10.1021/jm950498t
		10424220	109643	0	None	-7	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	288	5	1	1	4.3	CCCN(CCC)C1CCc2cc(F)c3[nH]ccc3c2C1	10.1021/jm00012a021
		CHEMBL305743	109643	0	None	-7	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	288	5	1	1	4.3	CCCN(CCC)C1CCc2cc(F)c3[nH]ccc3c2C1	10.1021/jm00012a021
		2543	10479	68	None	-1	32	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(00)00133-5
		5358	10479	68	None	-1	32	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(00)00133-5
		54	10479	68	None	-1	32	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(00)00133-5
		CHEMBL128	10479	68	None	-1	32	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(00)00133-5
		DB00669	10479	68	None	-1	32	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(00)00133-5
		44376723	126636	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	436	6	2	3	5.3	S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C1CCCCC1	10.1016/j.bmcl.2003.11.023
		CHEMBL348756	126636	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	436	6	2	3	5.3	S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C1CCCCC1	10.1016/j.bmcl.2003.11.023
		44376588	126730	0	None	12	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	465	7	1	4	4.3	COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		CHEMBL349675	126730	0	None	12	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	465	7	1	4	4.3	COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		24881264	195086	0	None	-13	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	709	19	4	4	10.3	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL500488	195086	0	None	-13	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	709	19	4	4	10.3	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL5090884	222356	0	None	-1	7	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5096072	222356	0	None	-1	7	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		168293874	198958	0	None	-25	11	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		CHEMBL5204071	198958	0	None	-25	11	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		44339071	15207	1	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	288	4	1	3	3.2	CN(C)CCc1c[nH]c2ccc(OC(=O)C(C)(C)C)cc12	10.1021/jm950498t
		CHEMBL109360	15207	1	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	288	4	1	3	3.2	CN(C)CCc1c[nH]c2ccc(OC(=O)C(C)(C)C)cc12	10.1021/jm950498t
		11728004	11225	0	None	-5	3	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	356	8	2	3	4.7	CCCCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		CHEMBL101686	11225	0	None	-5	3	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	356	8	2	3	4.7	CCCCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		11120893	11294	0	None	-239	4	Human	6.0	pKi	=	6.0	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	324	3	2	4	3.2	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1	10.1021/jm030020m
		CHEMBL102250	11294	0	None	-239	4	Human	6.0	pKi	=	6.0	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	324	3	2	4	3.2	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1	10.1021/jm030020m
		10698907	127809	0	None	-1202	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	605	12	4	9	2.4	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(C(=O)OCCO)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		CHEMBL356623	127809	0	None	-1202	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	605	12	4	9	2.4	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(C(=O)OCCO)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		11726413	108883	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	366	6	1	2	4.9	CCCN(CCC)C1CCc2ccc3[nH]cc(C(=O)C(F)(F)F)c3c2C1	10.1021/jm00012a021
		CHEMBL302263	108883	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	366	6	1	2	4.9	CCCN(CCC)C1CCc2ccc3[nH]cc(C(=O)C(F)(F)F)c3c2C1	10.1021/jm00012a021
		71061709	156306	0	None	-7	12	Mouse	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3946540	156306	0	None	-7	12	Mouse	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		10982183	99995	0	None	-9772	3	Human	6.0	pKi	=	6.0	Binding	Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 1D receptor expressed in HEK 293 cells using [3H]LSD as radioligandBinding constant towards serotonin receptor subtype 5-hydroxytryptamine 1D receptor expressed in HEK 293 cells using [3H]LSD as radioligand	ChEMBL	396	3	2	6	1.7	Nc1ccc(S(=O)(=O)c2cc(Br)nc(N3CCNCC3)c2)cc1	10.1021/jm021085c
		CHEMBL24474	99995	0	None	-9772	3	Human	6.0	pKi	=	6.0	Binding	Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 1D receptor expressed in HEK 293 cells using [3H]LSD as radioligandBinding constant towards serotonin receptor subtype 5-hydroxytryptamine 1D receptor expressed in HEK 293 cells using [3H]LSD as radioligand	ChEMBL	396	3	2	6	1.7	Nc1ccc(S(=O)(=O)c2cc(Br)nc(N3CCNCC3)c2)cc1	10.1021/jm021085c
		46853762	131261	0	None	4	2	Human	6.0	pKi	=	6.0	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL	434	6	1	7	3.1	CC[C@H](CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cc(C)cc(C)c23)c1=O	10.6019/CHEMBL4800723
		CHEMBL3640116	131261	0	None	4	2	Human	6.0	pKi	=	6.0	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL	434	6	1	7	3.1	CC[C@H](CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cc(C)cc(C)c23)c1=O	10.6019/CHEMBL4800723
		76319310	113099	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	321	4	1	2	3.2	CNC(C)COc1ccc(Br)cc1Br	10.1007/s00044-009-9164-1
		CHEMBL2260928	113099	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	321	4	1	2	3.2	CNC(C)COc1ccc(Br)cc1Br	10.1007/s00044-009-9164-1
		CHEMBL3139131	113099	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	321	4	1	2	3.2	CNC(C)COc1ccc(Br)cc1Br	10.1007/s00044-009-9164-1
		46853762	131261	0	None	4	2	Human	6.0	pKi	=	6.0	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL	434	6	1	7	3.1	CC[C@H](CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cc(C)cc(C)c23)c1=O	10.6019/CHEMBL4800723
		CHEMBL3640116	131261	0	None	4	2	Human	6.0	pKi	=	6.0	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL	434	6	1	7	3.1	CC[C@H](CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cc(C)cc(C)c23)c1=O	10.6019/CHEMBL4800723
		CHEMBL41844	170011	0	None	-323	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	590	10	2	9	4.6	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)N=C(C)/C(=C(/O)OC)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		1220	6975	55	None	-95	44	Human	6.9	pKi	=	6.9	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/s0960-894x(98)00222-4
		31	6975	55	None	-95	44	Human	6.9	pKi	=	6.9	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/s0960-894x(98)00222-4
		7	6975	55	None	-95	44	Human	6.9	pKi	=	6.9	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/s0960-894x(98)00222-4
		CHEMBL56	6975	55	None	-95	44	Human	6.9	pKi	=	6.9	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/s0960-894x(98)00222-4
		44456395	102446	0	None	-93	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	225	1	2	4	2.0	COc1c(Cl)ccc2c1C(C)NC(N)=N2	10.1016/j.bmcl.2007.10.080
		CHEMBL258073	102446	0	None	-93	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	225	1	2	4	2.0	COc1c(Cl)ccc2c1C(C)NC(N)=N2	10.1016/j.bmcl.2007.10.080
		9881478	13423	27	None	-3	2	Human	5.9	pKi	=	5.9	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	216	1	2	2	2.0	COc1ccc2[nH]c3c(c2c1)CC(N)CC3	10.1021/jm950498t
		CHEMBL108337	13423	27	None	-3	2	Human	5.9	pKi	=	5.9	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	216	1	2	2	2.0	COc1ccc2[nH]c3c(c2c1)CC(N)CC3	10.1021/jm950498t
		44376280	126681	0	None	11	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	449	6	1	3	4.6	Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		CHEMBL349174	126681	0	None	11	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	449	6	1	3	4.6	Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		44376282	126886	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	464	6	2	3	5.4	S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccc(Cl)cc1	10.1016/j.bmcl.2003.11.023
		CHEMBL351036	126886	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	464	6	2	3	5.4	S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccc(Cl)cc1	10.1016/j.bmcl.2003.11.023
		10618751	41964	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	364	7	1	4	3.3	CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		CHEMBL143510	41964	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	364	7	1	4	3.3	CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		129503	168447	10	None	2	4	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	214	1	1	1	2.6	CN(C)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL413105	168447	10	None	2	4	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	214	1	1	1	2.6	CN(C)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		14973078	106432	0	None	-48	6	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	379	7	0	4	3.9	CCCN(CCC)C1CCc2cccc(OS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL28437	106432	0	None	-48	6	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	379	7	0	4	3.9	CCCN(CCC)C1CCc2cccc(OS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		107780	8625	54	None	-1	18	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/j.bmcl.2005.07.024
		14	8625	54	None	-1	18	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/j.bmcl.2005.07.024
		CHEMBL15928	8625	54	None	-1	18	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/j.bmcl.2005.07.024
		44402870	77890	0	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	434	3	1	4	4.3	COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)Nc1cccc(Cl)c1Cl)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL195432	77890	0	None	-3	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	434	3	1	4	4.3	COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)Nc1cccc(Cl)c1Cl)CC2	10.1016/j.bmcl.2005.07.085
		11796257	105456	1	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	417	4	1	4	3.8	COc1ccc(NC(=O)c2ccc(Br)c(C)c2)cc1N1CCN(C)CC1	10.1021/jm970457s
		CHEMBL277467	105456	1	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	417	4	1	4	3.8	COc1ccc(NC(=O)c2ccc(Br)c(C)c2)cc1N1CCN(C)CC1	10.1021/jm970457s
		44330232	114338	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	373	3	2	4	3.5	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc(Cl)c1)[C@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL318906	114338	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	373	3	2	4	3.5	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc(Cl)c1)[C@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		9843458	149433	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	391	3	2	4	3.7	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccc(F)c(Cl)c1)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL38918	149433	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	391	3	2	4	3.7	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccc(F)c(Cl)c1)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		10073139	191075	0	None	-39	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	464	5	1	5	4.6	O=C1COc2ccc(CCN3CCN(c4cccc5nc(-c6ccccc6)ccc45)CC3)cc2N1	10.1016/j.bmcl.2008.08.084
		CHEMBL484059	191075	0	None	-39	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	464	5	1	5	4.6	O=C1COc2ccc(CCN3CCN(c4cccc5nc(-c6ccccc6)ccc45)CC3)cc2N1	10.1016/j.bmcl.2008.08.084
		10048343	190998	0	None	-19	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	430	6	1	5	4.0	Cc1ccc2c(N3CCN(CCCCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL483365	190998	0	None	-19	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	430	6	1	5	4.0	Cc1ccc2c(N3CCN(CCCCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		24865539	194424	0	None	1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	391	7	0	5	3.7	COc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1	10.1021/jm8001444
		CHEMBL494991	194424	0	None	1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	391	7	0	5	3.7	COc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1	10.1021/jm8001444
		25130235	194366	1	None	-3	11	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		25130235	194366	1	None	-3	11	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		CHEMBL494678	194366	1	None	-3	11	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		CHEMBL494678	194366	1	None	-3	11	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm800670r
		10786335	18832	0	None	-63	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	385	5	1	4	3.9	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1C#CCN(C)C	10.1021/jm9702948
		CHEMBL118360	18832	0	None	-63	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	385	5	1	4	3.9	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1C#CCN(C)C	10.1021/jm9702948
		92042876	158115	0	None	-229	10	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL3961059	158115	0	None	-229	10	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		72550645	120866	0	None	-17	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT1D (unknown origin)Binding affinity to 5-HT1D (unknown origin)	ChEMBL	505	11	1	4	6.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326993	120866	0	None	-17	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT1D (unknown origin)Binding affinity to 5-HT1D (unknown origin)	ChEMBL	505	11	1	4	6.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
		44461336	112904	0	None	-14	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	469	5	2	3	5.1	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(C(F)(F)F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL313452	112904	0	None	-14	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	469	5	2	3	5.1	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(C(F)(F)F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		56649648	74630	0	None	-371	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		CHEMBL1910139	74630	0	None	-371	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		1574	6869	60	None	-12	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm00164a046
		218	6869	60	None	-12	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm00164a046
		CHEMBL266591	6869	60	None	-12	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm00164a046
		142601328	191782	0	None	-77	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4854605	191782	0	None	-77	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		62597539	112989	2	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	307	4	1	2	2.8	CNCCOc1ccc(Br)cc1Br	10.1007/s00044-009-9164-1
		CHEMBL2260923	112989	2	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	307	4	1	2	2.8	CNCCOc1ccc(Br)cc1Br	10.1007/s00044-009-9164-1
		CHEMBL3138772	112989	2	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	307	4	1	2	2.8	CNCCOc1ccc(Br)cc1Br	10.1007/s00044-009-9164-1
		10088426	20527	0	None	-4	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-HT1D alpha receptor by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-HT1D alpha receptor by using [3H]5-HT as radioligand	ChEMBL	337	5	1	4	2.8	CCCN[C@@H]1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1	10.1021/jm00008a010
		CHEMBL1195292	20527	0	None	-4	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-HT1D alpha receptor by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-HT1D alpha receptor by using [3H]5-HT as radioligand	ChEMBL	337	5	1	4	2.8	CCCN[C@@H]1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1	10.1021/jm00008a010
		CHEMBL554220	20527	0	None	-4	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-HT1D alpha receptor by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-HT1D alpha receptor by using [3H]5-HT as radioligand	ChEMBL	337	5	1	4	2.8	CCCN[C@@H]1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1	10.1021/jm00008a010
		44402878	78182	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	506	4	1	5	5.6	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL195897	78182	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	506	4	1	5	5.6	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2	10.1016/j.bmcl.2005.07.085
		44402887	78509	0	None	-79	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	479	4	0	4	4.5	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(C(F)(F)F)c1F)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL196600	78509	0	None	-79	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	479	4	0	4	4.5	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(C(F)(F)F)c1F)CC2	10.1016/j.bmcl.2005.07.085
		44402868	175124	0	None	-31	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	534	5	0	5	6.3	CCN1[C@@H](C)CN(c2cc3c(cc2OC)CCN3C(=O)c2ccc(-c3cccc(C)n3)c3ccccc23)C[C@H]1C	10.1016/j.bmcl.2005.07.085
		CHEMBL434355	175124	0	None	-31	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	534	5	0	5	6.3	CCN1[C@@H](C)CN(c2cc3c(cc2OC)CCN3C(=O)c2ccc(-c3cccc(C)n3)c3ccccc23)C[C@H]1C	10.1016/j.bmcl.2005.07.085
		127036953	144293	0	None	-12	22	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754166	144293	0	None	-12	22	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		44588698	191099	0	None	5	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	388	3	1	5	3.2	Cc1ccc2c(N3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL484205	191099	0	None	5	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	388	3	1	5	3.2	Cc1ccc2c(N3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		9935387	106218	0	None	-158	14	Human	6.9	pKi	=	6.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
		CHEMBL282971	106218	0	None	-158	14	Human	6.9	pKi	=	6.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
		10095692	31896	0	None	-7	4	Human	5.9	pKi	=	5.9	Binding	Affinity at 5-hydroxytryptamine 1D receptor from calf caudate using [3H]5-HT as radioligand (For sumatriptan = Ki(nM)-12+/-1.9)Affinity at 5-hydroxytryptamine 1D receptor from calf caudate using [3H]5-HT as radioligand (For sumatriptan = Ki(nM)-12+/-1.9)	ChEMBL	458	8	0	5	6.2	COc1ccccc1N1CCN(CCC(Oc2cccc3ccccc23)c2ccsc2)CC1	10.1021/jm001059j
		CHEMBL134743	31896	0	None	-7	4	Human	5.9	pKi	=	5.9	Binding	Affinity at 5-hydroxytryptamine 1D receptor from calf caudate using [3H]5-HT as radioligand (For sumatriptan = Ki(nM)-12+/-1.9)Affinity at 5-hydroxytryptamine 1D receptor from calf caudate using [3H]5-HT as radioligand (For sumatriptan = Ki(nM)-12+/-1.9)	ChEMBL	458	8	0	5	6.2	COc1ccccc1N1CCN(CCC(Oc2cccc3ccccc23)c2ccsc2)CC1	10.1021/jm001059j
		70683414	81256	0	None	-34	4	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL2021524	81256	0	None	-34	4	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL2028030	81256	0	None	-34	4	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		143	10288	51	None	-177	6	Human	5.9	pKi	=	5.9	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1021/jm000090i
		5311096	10288	51	None	-177	6	Human	5.9	pKi	=	5.9	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1021/jm000090i
		CHEMBL85606	10288	51	None	-177	6	Human	5.9	pKi	=	5.9	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1021/jm000090i
		9954121	103181	0	None	-1995	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	424	4	2	5	3.7	CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)cc1	10.1016/s0960-894x(01)00558-3
		CHEMBL261917	103181	0	None	-1995	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	424	4	2	5	3.7	CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)cc1	10.1016/s0960-894x(01)00558-3
		11191906	18539	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
		CHEMBL1181665	18539	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
		CHEMBL187928	18539	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
		44588743	191284	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	403	4	1	5	3.9	Cc1ccc2c(OC3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL484742	191284	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	403	4	1	5	3.9	Cc1ccc2c(OC3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		44588744	191286	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	417	5	1	5	4.2	Cc1ccc2c(OCC3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL484743	191286	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	417	5	1	5	4.2	Cc1ccc2c(OCC3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		9957068	58718	0	None	-251	5	Human	5.9	pKi	=	5.9	Binding	Evaluated for the binding affinity against 5-hydroxytryptamine 1D receptorEvaluated for the binding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	486	8	1	5	4.3	CS(=O)(=O)Oc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccc(F)cc3)CC1)C2	10.1016/s0960-894x(01)00037-3
		CHEMBL158627	58718	0	None	-251	5	Human	5.9	pKi	=	5.9	Binding	Evaluated for the binding affinity against 5-hydroxytryptamine 1D receptorEvaluated for the binding affinity against 5-hydroxytryptamine 1D receptor	ChEMBL	486	8	1	5	4.3	CS(=O)(=O)Oc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccc(F)cc3)CC1)C2	10.1016/s0960-894x(01)00037-3
		9904281	54523	28	None	-29	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	2	3	2.0	NC1=Nc2ccc(Cl)c(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
		CHEMBL1548	54523	28	None	-29	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	2	3	2.0	NC1=Nc2ccc(Cl)c(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
		14973078	106432	0	None	-48	6	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligand	ChEMBL	379	7	0	4	3.9	CCCN(CCC)C1CCc2cccc(OS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL28437	106432	0	None	-48	6	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligand	ChEMBL	379	7	0	4	3.9	CCCN(CCC)C1CCc2cccc(OS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		16006492	104245	7	None	-316	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL270177	104245	7	None	-316	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		44455943	175781	5	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	243	1	2	3	3.0	CCC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL439240	175781	5	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	243	1	2	3	3.0	CCC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
		122483223	144887	0	None	-17	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3764650	144887	0	None	-17	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765874	144887	0	None	-17	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		10198320	211389	1	None	46	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	218	2	2	1	3.1	Cc1cc(C(C)(C)C)cc(C)c1CC(=N)N	10.1021/jm970513p
		CHEMBL73281	211389	1	None	46	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	218	2	2	1	3.1	Cc1cc(C(C)(C)C)cc(C)c1CC(=N)N	10.1021/jm970513p
		24882266	195066	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	812	17	4	4	11.6	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL500230	195066	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	812	17	4	4	11.6	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		24882267	195106	0	None	776	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	840	19	4	4	12.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL500749	195106	0	None	776	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	840	19	4	4	12.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		24881619	195817	0	None	9	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	826	18	4	4	12.0	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL509314	195817	0	None	9	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	826	18	4	4	12.0	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		10475893	170710	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	396	8	1	2	5.9	CCCN(CCCOc1cccc(Cl)c1)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL420748	170710	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	396	8	1	2	5.9	CCCN(CCCOc1cccc(Cl)c1)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		10382523	211036	0	None	-21	3	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	338	6	1	2	5.0	CCCN(CCc1cccs1)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL71145	211036	0	None	-21	3	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	338	6	1	2	5.0	CCCN(CCc1cccs1)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		2393	10107	82	None	1	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00018a020
		5078	10107	82	None	1	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00018a020
		51	10107	82	None	1	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00018a020
		CHEMBL905	10107	82	None	1	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00018a020
		DB00953	10107	82	None	1	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00018a020
		44461251	112174	0	None	-8	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	426	5	2	4	3.9	N#Cc1cccc2c(C3=CCN(CCC4OCCc5cc(C(N)=O)ccc54)CC3)c[nH]c12	10.1016/j.bmcl.2004.03.003
		CHEMBL311694	112174	0	None	-8	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	426	5	2	4	3.9	N#Cc1cccc2c(C3=CCN(CCC4OCCc5cc(C(N)=O)ccc54)CC3)c[nH]c12	10.1016/j.bmcl.2004.03.003
		44461293	212113	0	None	-61	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL79561	212113	0	None	-61	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.bmcl.2004.03.003
		70681318	81258	0	None	-9	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2c(cccc2CS(=O)(=O)C(F)(F)F)C1	10.1021/jm00008a010
		CHEMBL2021538	81258	0	None	-9	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2c(cccc2CS(=O)(=O)C(F)(F)F)C1	10.1021/jm00008a010
		CHEMBL2028033	81258	0	None	-9	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2c(cccc2CS(=O)(=O)C(F)(F)F)C1	10.1021/jm00008a010
		134138168	154469	0	None	-117	10	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		CHEMBL3931889	154469	0	None	-117	10	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		49783209	24381	0	None	-2290	26	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5-HT1D receptorBinding affinity to human 5-HT1D receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258223	24381	0	None	-2290	26	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5-HT1D receptorBinding affinity to human 5-HT1D receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		10527410	212709	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in calf caudate homogenates.Binding affinity against 5-hydroxytryptamine 1D receptor in calf caudate homogenates.	ChEMBL	447	9	3	4	2.3	CN(C)CCc1c(C(=O)NCc2ccccc2)[nH]c2ccc(CCN3C(=O)CNC3=O)cc12	10.1021/jm9706325
		CHEMBL84165	212709	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in calf caudate homogenates.Binding affinity against 5-hydroxytryptamine 1D receptor in calf caudate homogenates.	ChEMBL	447	9	3	4	2.3	CN(C)CCc1c(C(=O)NCc2ccccc2)[nH]c2ccc(CCN3C(=O)CNC3=O)cc12	10.1021/jm9706325
		16118923	66920	0	None	-1230	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT1D receptorBinding affinity to 5-HT1D receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
		CHEMBL1642866	66920	0	None	-1230	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT1D receptorBinding affinity to 5-HT1D receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
		CHEMBL1739656	66920	0	None	-1230	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT1D receptorBinding affinity to 5-HT1D receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
		2574642	211213	26	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	205	2	1	1	3.1	Cc1cc(C(C)(C)C)cc(C)c1CCN	10.1021/jm970513p
		CHEMBL72158	211213	26	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	205	2	1	1	3.1	Cc1cc(C(C)(C)C)cc(C)c1CCN	10.1021/jm970513p
		135458393	162375	4	None	-102	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	259	2	2	3	2.8	CC1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL404511	162375	4	None	-102	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	259	2	2	3	2.8	CC1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		151	9194	44	None	-151	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1021/jm7011722
		20	9194	44	None	-151	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1021/jm7011722
		5311258	9194	44	None	-151	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1021/jm7011722
		CHEMBL101690	9194	44	None	-151	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1021/jm7011722
		70691866	81239	0	None	-23	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL2021539	81239	0	None	-23	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL2027935	81239	0	None	-23	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		10062659	210953	1	None	-9	4	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	288	5	1	1	4.3	CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]ccc3c2C1	10.1021/jm00012a021
		CHEMBL70710	210953	1	None	-9	4	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	288	5	1	1	4.3	CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]ccc3c2C1	10.1021/jm00012a021
		44461443	212132	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	414	5	1	3	4.8	NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2cccc3ccccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL79693	212132	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	414	5	1	3	4.8	NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2cccc3ccccc23)CC1	10.1016/j.bmcl.2004.03.003
		122197403	140252	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	433	5	1	4	4.3	C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		CHEMBL3706923	140252	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	433	5	1	4	4.3	C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		44431534	152017	0	None	21	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	447	5	1	4	4.3	C[C@H]1CN(c2ccc3cc(F)ccc3c2)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		CHEMBL391272	152017	0	None	21	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	447	5	1	4	4.3	C[C@H]1CN(c2ccc3cc(F)ccc3c2)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		24893978	7797	9	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
		8872	7797	9	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
		CHEMBL495075	7797	9	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
		44395832	129972	5	None	-64	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	351	3	1	3	4.3	CN1CCC(n2ccc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1	10.1016/j.bmcl.2004.09.079
		CHEMBL361303	129972	5	None	-64	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	351	3	1	3	4.3	CN1CCC(n2ccc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1	10.1016/j.bmcl.2004.09.079
		122483275	144888	0	None	-64	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764133	144888	0	None	-64	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765875	144888	0	None	-64	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		16093485	161842	0	None	-57	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	239	1	2	4	2.3	COc1cc(Cl)c(C)c2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		CHEMBL401745	161842	0	None	-57	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	239	1	2	4	2.3	COc1cc(Cl)c(C)c2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		44582708	193617	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
		CHEMBL489408	193617	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
		136152964	201718	0	None	-501	8	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor	ChEMBL	259	2	2	3	2.8	C[C@@H]1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL541993	201718	0	None	-501	8	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor	ChEMBL	259	2	2	3	2.8	C[C@@H]1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
		44582678	188353	0	None	-10	10	Human	5.8	pKi	=	5.8	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL476839	188353	0	None	-10	10	Human	5.8	pKi	=	5.8	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		44461266	110997	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	435	5	2	3	4.7	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(Cl)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL309872	110997	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	435	5	2	3	4.7	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(Cl)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		135458392	104201	5	None	-162	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	209	0	2	3	2.2	CNC1=Nc2cccc(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
		CHEMBL269964	104201	5	None	-162	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	209	0	2	3	2.2	CNC1=Nc2cccc(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
		135367857	171383	0	None	-9	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4215875	171383	0	None	-9	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		10924369	16108	1	None	-9332	6	Human	5.8	pKi	=	5.8	Binding	The binding affinity at 5-hydroxytryptamine 1D receptor was determined using [3H]5-CTThe binding affinity at 5-hydroxytryptamine 1D receptor was determined using [3H]5-CT	ChEMBL	294	1	0	3	3.1	COc1cccc2c1N1CCN(C)C[C@@H]1c1ccccc1C2	10.1021/jm010566d
		CHEMBL111184	16108	1	None	-9332	6	Human	5.8	pKi	=	5.8	Binding	The binding affinity at 5-hydroxytryptamine 1D receptor was determined using [3H]5-CTThe binding affinity at 5-hydroxytryptamine 1D receptor was determined using [3H]5-CT	ChEMBL	294	1	0	3	3.1	COc1cccc2c1N1CCN(C)C[C@@H]1c1ccccc1C2	10.1021/jm010566d
		50878551	97520	61	None	-3	18	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		CHEMBL2391541	97520	61	None	-3	18	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		76326516	113006	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	364	5	0	3	4.4	CN1CCN([C@@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1	10.1007/s00044-009-9164-1
		CHEMBL2260933	113006	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	364	5	0	3	4.4	CN1CCN([C@@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1	10.1007/s00044-009-9164-1
		CHEMBL3138820	113006	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	364	5	0	3	4.4	CN1CCN([C@@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1	10.1007/s00044-009-9164-1
		16117279	66910	0	None	-1479	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT1D receptorBinding affinity to 5-HT1D receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
		CHEMBL1642886	66910	0	None	-1479	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT1D receptorBinding affinity to 5-HT1D receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
		CHEMBL1739606	66910	0	None	-1479	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT1D receptorBinding affinity to 5-HT1D receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
		49799868	17311	0	None	-2	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CC=C(c2c[nH]c3c(F)cccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL1169435	17311	0	None	-2	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CC=C(c2c[nH]c3c(F)cccc23)CC1	10.1016/j.bmcl.2004.03.003
		14547414	109061	1	None	1	4	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	214	1	1	1	2.6	CN(C)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL303339	109061	1	None	1	4	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	214	1	1	1	2.6	CN(C)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		14977566	106248	1	None	-18	6	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	337	5	1	4	2.8	CCCNC1CCc2cccc(OS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL28313	106248	1	None	-18	6	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	337	5	1	4	2.8	CCCNC1CCc2cccc(OS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		44403106	78190	0	None	-1	4	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	438	6	1	6	3.3	COc1ccccc1N1CCC(C(=O)Nc2ccc(OC)c(N3CCN(C)CC3)c2)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL195927	78190	0	None	-1	4	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	438	6	1	6	3.3	COc1ccccc1N1CCC(C(=O)Nc2ccc(OC)c(N3CCN(C)CC3)c2)CC1	10.1016/j.bmcl.2005.07.024
		44402885	78589	0	None	-25	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	469	4	0	4	5.4	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3ccccc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL196848	78589	0	None	-25	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	469	4	0	4	5.4	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3ccccc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		44402894	104985	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	551	5	0	7	5.8	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL274256	104985	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	551	5	0	7	5.8	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		44330217	114187	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	407	3	2	4	4.2	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc(Cl)c1Cl)[C@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL318022	114187	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	407	3	2	4	4.2	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc(Cl)c1Cl)[C@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		44330243	114334	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	379	3	2	5	3.6	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccsc1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL318882	114334	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	379	3	2	5	3.6	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccsc1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		44404230	77294	0	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	440	2	0	4	4.2	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2C(F)(F)F)CC4)CC1	10.1016/j.bmcl.2005.06.042
		CHEMBL194701	77294	0	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	440	2	0	4	4.2	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2C(F)(F)F)CC4)CC1	10.1016/j.bmcl.2005.06.042
		50878551	97520	61	None	-3	18	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL2391541	97520	61	None	-3	18	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		152	7152	29	None	-34	19	Human	6.8	pKi	=	6.8	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm00164a046
		2107	7152	29	None	-34	19	Human	6.8	pKi	=	6.8	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm00164a046
		CHEMBL275854	7152	29	None	-34	19	Human	6.8	pKi	=	6.8	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm00164a046
		22611622	11466	8	None	-15	4	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	271	2	2	2	2.9	CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1	10.1021/jm030020m
		CHEMBL103424	11466	8	None	-15	4	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	271	2	2	2	2.9	CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1	10.1021/jm030020m
		24881687	179593	0	None	3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	776	10	4	4	10.2	O=C(Nc1ccc2[nH]cc(C3CCN(Cc4cccc(CN5CCC(c6c[nH]c7ccc(NC(=O)c8ccc(F)cc8)cc67)CC5)c4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL451394	179593	0	None	3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	776	10	4	4	10.2	O=C(Nc1ccc2[nH]cc(C3CCN(Cc4cccc(CN5CCC(c6c[nH]c7ccc(NC(=O)c8ccc(F)cc8)cc67)CC5)c4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		9948210	109898	1	None	-245	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	298	6	1	2	4.0	CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		CHEMBL307786	109898	1	None	-245	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	298	6	1	2	4.0	CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		70683414	81256	0	None	-34	4	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL2021524	81256	0	None	-34	4	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL2028030	81256	0	None	-34	4	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		44402869	140921	0	None	-5	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	548	6	0	5	6.7	CCCN1[C@@H](C)CN(c2cc3c(cc2OC)CCN3C(=O)c2ccc(-c3cccc(C)n3)c3ccccc23)C[C@H]1C	10.1016/j.bmcl.2005.07.085
		CHEMBL371655	140921	0	None	-5	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	548	6	0	5	6.7	CCCN1[C@@H](C)CN(c2cc3c(cc2OC)CCN3C(=O)c2ccc(-c3cccc(C)n3)c3ccccc23)C[C@H]1C	10.1016/j.bmcl.2005.07.085
		44402881	172593	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	480	3	1	4	5.0	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(C(F)(F)F)c1F)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL424837	172593	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	480	3	1	4	5.0	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(C(F)(F)F)c1F)CC2	10.1016/j.bmcl.2005.07.085
		44330231	214932	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	345	3	2	5	3.0	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccsc1)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL98195	214932	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	345	3	2	5	3.0	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccsc1)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		9889681	214842	0	None	-316	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	444	5	2	5	4.1	O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(-c2ccccc2)cc1	10.1016/s0960-894x(01)00558-3
		CHEMBL97637	214842	0	None	-316	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	444	5	2	5	4.1	O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(-c2ccccc2)cc1	10.1016/s0960-894x(01)00558-3
		9827938	18543	0	None	-6	12	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
		CHEMBL1181680	18543	0	None	-6	12	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
		CHEMBL188486	18543	0	None	-6	12	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
		44588722	198020	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	433	8	1	6	3.7	Cc1ccc2c(OCCCN3CC(COc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL519010	198020	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	433	8	1	6	3.7	Cc1ccc2c(OCCCN3CC(COc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1	10.1016/j.bmcl.2008.08.110
		50878551	97520	61	None	-3	18	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		CHEMBL2391541	97520	61	None	-3	18	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		3233	10285	44	None	-1174	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		3247	10285	44	None	-1174	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		6604889	10285	44	None	-1174	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		CHEMBL282199	10285	44	None	-1174	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		DB13988	10285	44	None	-1174	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
		44330272	174979	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	341	3	2	6	1.7	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cnccn1)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL433377	174979	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	341	3	2	6	1.7	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cnccn1)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		10858566	108864	1	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	270	5	1	1	4.1	CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a021
		CHEMBL302172	108864	1	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	270	5	1	1	4.1	CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a021
		10775128	195510	3	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	216	4	1	1	2.8	CCc1ccc2[nH]cc(CCN(C)C)c2c1	10.1016/s0960-894x(00)00322-x
		CHEMBL50492	195510	3	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	216	4	1	1	2.8	CCc1ccc2[nH]cc(CCN(C)C)c2c1	10.1016/s0960-894x(00)00322-x
		44376363	62126	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	480	6	2	3	5.9	S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1cccc2ccccc12	10.1016/j.bmcl.2003.11.023
		CHEMBL161894	62126	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	480	6	2	3	5.9	S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1cccc2ccccc12	10.1016/j.bmcl.2003.11.023
		106	6936	26	None	-5	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HTBinding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HT	ChEMBL	302	11	2	2	4.8	CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2	10.1021/jm00044a001
		1797	6936	26	None	-5	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HTBinding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HT	ChEMBL	302	11	2	2	4.8	CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2	10.1021/jm00044a001
		CHEMBL97450	6936	26	None	-5	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HTBinding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HT	ChEMBL	302	11	2	2	4.8	CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2	10.1021/jm00044a001
		9928474	16105	0	None	-6	3	Human	7.8	pKi	=	7.8	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	316	9	2	2	5.0	CC(C)(C)CCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		CHEMBL111150	16105	0	None	-6	3	Human	7.8	pKi	=	7.8	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	316	9	2	2	5.0	CC(C)(C)CCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		10858566	108864	1	None	-2	4	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	270	5	1	1	4.1	CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL302172	108864	1	None	-2	4	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	270	5	1	1	4.1	CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		10015980	211096	0	None	-22	4	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	270	4	1	2	3.2	CCCN(C)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL71469	211096	0	None	-22	4	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	270	4	1	2	3.2	CCCN(C)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		135966709	161934	4	None	-66	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	233	2	2	4	2.3	CNC1=Nc2c(OC(C)C)cccc2C(C)N1	10.1016/j.bmcl.2007.10.080
		CHEMBL402179	161934	4	None	-66	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	233	2	2	4	2.3	CNC1=Nc2c(OC(C)C)cccc2C(C)N1	10.1016/j.bmcl.2007.10.080
		145977799	170422	0	None	-2	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4204036	170422	0	None	-2	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		44352308	124265	0	None	-199	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor was determined using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor was determined using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
		CHEMBL339980	124265	0	None	-199	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor was determined using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor was determined using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
		1220	6975	55	None	-95	44	Human	6.8	pKi	=	6.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00012a021
		31	6975	55	None	-95	44	Human	6.8	pKi	=	6.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00012a021
		7	6975	55	None	-95	44	Human	6.8	pKi	=	6.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00012a021
		CHEMBL56	6975	55	None	-95	44	Human	6.8	pKi	=	6.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00012a021
		6603866	104204	17	None	-630	9	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm00008a010
		CHEMBL26998	104204	17	None	-630	9	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm00008a010
		CHEMBL541268	104204	17	None	-630	9	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm00008a010
		44461308	212724	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	469	5	2	3	5.4	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3c(Cl)c(Cl)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL84305	212724	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	469	5	2	3	5.4	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3c(Cl)c(Cl)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		135367405	170975	0	None	-3	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4210782	170975	0	None	-3	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		44403098	77047	0	None	-4	4	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	427	4	1	5	2.9	COc1ccc(NC(=O)N2CCN(c3ccc(F)cc3)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL194206	77047	0	None	-4	4	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	427	4	1	5	2.9	COc1ccc(NC(=O)N2CCN(c3ccc(F)cc3)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		10500422	85250	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	387	7	1	4	4.6	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C\CN(C)C	10.1021/jm9702948
		CHEMBL2111779	85250	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	387	7	1	4	4.6	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C\CN(C)C	10.1021/jm9702948
		14977566	106248	1	None	-18	6	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	337	5	1	4	2.8	CCCNC1CCc2cccc(OS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL28313	106248	1	None	-18	6	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand	ChEMBL	337	5	1	4	2.8	CCCNC1CCc2cccc(OS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		44338900	116421	1	None	3	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	260	5	1	3	2.6	CCC(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm950498t
		CHEMBL322349	116421	1	None	3	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	260	5	1	3	2.6	CCC(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm950498t
		10243466	211086	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	242	3	1	1	3.4	CCCN(C)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL71409	211086	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	242	3	1	1	3.4	CCCN(C)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		11003379	115878	0	None	-8	3	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	379	4	2	5	3.5	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4[N+](=O)[O-])nc23)CC1	10.1021/jm030020m
		CHEMBL321343	115878	0	None	-8	3	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	379	4	2	5	3.5	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4[N+](=O)[O-])nc23)CC1	10.1021/jm030020m
		178081	109426	8	None	-338	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	298	6	1	2	4.0	CCCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		CHEMBL304426	109426	8	None	-338	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	298	6	1	2	4.0	CCCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		155770281	184526	0	None	-2	9	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT1D (unknown origin)Binding affinity to 5HT1D (unknown origin)	ChEMBL	517	4	1	2	7.6	CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		CHEMBL4642592	184526	0	None	-2	9	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT1D (unknown origin)Binding affinity to 5HT1D (unknown origin)	ChEMBL	517	4	1	2	7.6	CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		155770281	184526	0	None	-2	9	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	517	4	1	2	7.6	CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.0c00745
		CHEMBL4642592	184526	0	None	-2	9	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	517	4	1	2	7.6	CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.0c00745
		10555134	47571	0	None	-416	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	573	9	2	8	4.0	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(C)=O)C2c2ccc3c(c2)OCO3)CC1	10.1021/jm980506g
		CHEMBL148552	47571	0	None	-416	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	573	9	2	8	4.0	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(C)=O)C2c2ccc3c(c2)OCO3)CC1	10.1021/jm980506g
		1534	109817	53	None	-18	12	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		9287	109817	53	None	-18	12	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		CHEMBL30713	109817	53	None	-18	12	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		9973090	109784	0	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	316	6	1	2	4.9	CCCN(CCC)C1CCc2ccc3[nH]cc(SC)c3c2C1	10.1021/jm00012a021
		CHEMBL306869	109784	0	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	316	6	1	2	4.9	CCCN(CCC)C1CCc2ccc3[nH]cc(SC)c3c2C1	10.1021/jm00012a021
		9796627	103428	0	None	-6	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	308	4	1	4	3.1	CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12	10.1021/jm010943m
		CHEMBL263700	103428	0	None	-6	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	308	4	1	4	3.1	CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12	10.1021/jm010943m
		11011968	11713	0	None	-181	4	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	298	3	2	3	2.7	CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1	10.1021/jm030020m
		CHEMBL104720	11713	0	None	-181	4	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	298	3	2	3	2.7	CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1	10.1021/jm030020m
		CHEMBL4535474	220767	39	None	-1	6	Human	6.7	pKi	=	6.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000320b HTR1DSelectivity interaction (GPCR panel (PDSP screen)) EUB0000320b HTR1D	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		136152966	102368	0	None	-102	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	289	3	2	4	2.9	COc1c(Cl)ccc2c1C(C)NC(NCC(F)F)=N2	10.1016/j.bmcl.2007.10.078
		CHEMBL257744	102368	0	None	-102	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	289	3	2	4	2.9	COc1c(Cl)ccc2c1C(C)NC(NCC(F)F)=N2	10.1016/j.bmcl.2007.10.078
		CHEMBL4748908	220814	1	None	-22	12	Human	5.7	pKi	=	5.7	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
		44582707	193777	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL490634	193777	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL347501	126494	0	None	-512	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	620	12	3	10	3.9	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)N=C(C)/C(=C(/O)OCCO)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		10698608	50101	0	None	-40	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	588	10	3	7	2.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(C(=O)N(C)C)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		CHEMBL150696	50101	0	None	-40	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	588	10	3	7	2.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(C(=O)N(C)C)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		10266598	127149	1	None	37	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	296	4	1	2	4.5	c1csc(-c2ccc3[nH]cc(CCN4CCCC4)c3c2)c1	10.1016/s0960-894x(00)00133-5
		CHEMBL353256	127149	1	None	37	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	296	4	1	2	4.5	c1csc(-c2ccc3[nH]cc(CCN4CCCC4)c3c2)c1	10.1016/s0960-894x(00)00133-5
		CHEMBL5083607	221652	0	None	-1	9	Human	7.7	pKi	=	7.7	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
		10331989	69805	1	None	-1	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	242	2	1	2	2.4	CN(C)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL1788196	69805	1	None	-1	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	242	2	1	2	2.4	CN(C)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		10791443	83969	0	None	-7	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	497	7	1	7	5.0	Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)N(CCN(C)C)CCO5)cc3)c(C)c2)no1	10.1021/jm970457s
		CHEMBL20791	83969	0	None	-7	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	497	7	1	7	5.0	Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)N(CCN(C)C)CCO5)cc3)c(C)c2)no1	10.1021/jm970457s
		10547383	214974	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	373	3	2	4	3.5	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccccc1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL98433	214974	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	373	3	2	4	3.5	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccccc1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		11476072	76176	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	436	8	0	7	3.7	COc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1[N+](=O)[O-]	10.1021/jm049039v
		CHEMBL193268	76176	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	436	8	0	7	3.7	COc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1[N+](=O)[O-]	10.1021/jm049039v
		10691904	42394	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	392	9	1	4	4.1	CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		CHEMBL143967	42394	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	392	9	1	4	4.1	CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		10655811	211217	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	204	2	2	3	1.6	Cc1ccc(CC2=NCCN2)c(C)c1O	10.1021/jm970513p
		CHEMBL72167	211217	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	204	2	2	3	1.6	Cc1ccc(CC2=NCCN2)c(C)c1O	10.1021/jm970513p
		145977338	170496	0	None	-19	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
		CHEMBL4205064	170496	0	None	-19	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
		11024618	115330	0	None	-28	4	Human	5.7	pKi	=	5.7	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	353	3	2	4	3.2	CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)nc23)CC1	10.1021/jm030020m
		CHEMBL320198	115330	0	None	-28	4	Human	5.7	pKi	=	5.7	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	353	3	2	4	3.2	CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)nc23)CC1	10.1021/jm030020m
		9856041	30886	3	None	-524	8	Human	5.7	pKi	=	5.7	Binding	Inhibitory constant against human 5-hydroxytryptamine 5A receptor using [3H]LSD radioligandInhibitory constant against human 5-hydroxytryptamine 5A receptor using [3H]LSD radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		CHEMBL133868	30886	3	None	-524	8	Human	5.7	pKi	=	5.7	Binding	Inhibitory constant against human 5-hydroxytryptamine 5A receptor using [3H]LSD radioligandInhibitory constant against human 5-hydroxytryptamine 5A receptor using [3H]LSD radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
		10064500	210938	0	None	-100	4	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	318	5	1	1	4.9	CCCN(Cc1ccccc1)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL70606	210938	0	None	-100	4	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	318	5	1	1	4.9	CCCN(Cc1ccccc1)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		10793503	126493	0	None	-1000	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	588	11	2	8	4.5	CCOC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(C)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		CHEMBL347499	126493	0	None	-1000	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	588	11	2	8	4.5	CCOC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(C)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		10792347	128784	0	None	-30	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	531	9	3	6	3.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(C)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		CHEMBL359375	128784	0	None	-30	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	531	9	3	6	3.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(C)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		71062708	161085	0	None	-11	12	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3986651	161085	0	None	-11	12	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		44402880	78008	0	None	-63	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	479	4	0	4	4.5	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(F)c1C(F)(F)F)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL195651	78008	0	None	-63	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	479	4	0	4	4.5	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(F)c1C(F)(F)F)CC2	10.1016/j.bmcl.2005.07.085
		44402888	147310	0	None	-25	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	446	3	1	4	4.6	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(Cl)c1F)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL381035	147310	0	None	-25	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	446	3	1	4	4.6	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(Cl)c1F)CC2	10.1016/j.bmcl.2005.07.085
		11794624	86987	1	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	387	3	1	3	3.8	Cc1cc(C(=O)Nc2cccc(N3CCN(C)CC3)c2)ccc1Br	10.1021/jm970457s
		CHEMBL21369	86987	1	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	387	3	1	3	3.8	Cc1cc(C(=O)Nc2cccc(N3CCN(C)CC3)c2)ccc1Br	10.1021/jm970457s
		9890119	214836	0	None	-199	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	452	4	2	5	4.3	O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1	10.1016/s0960-894x(01)00558-3
		CHEMBL97596	214836	0	None	-199	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	452	4	2	5	4.3	O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1	10.1016/s0960-894x(01)00558-3
		10413595	168620	0	None	-630	11	Human	6.7	pKi	=	6.7	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as the radioligand	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		CHEMBL414628	168620	0	None	-630	11	Human	6.7	pKi	=	6.7	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as the radioligand	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
		6918648	108336	1	None	-323	14	Human	6.7	pKi	=	6.7	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
		CHEMBL29846	108336	1	None	-323	14	Human	6.7	pKi	=	6.7	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
		24865540	194455	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	418	7	1	5	3.7	CC(=O)Nc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1	10.1021/jm8001444
		CHEMBL495160	194455	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	418	7	1	5	3.7	CC(=O)Nc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1	10.1021/jm8001444
		6918648	108336	1	None	-323	14	Human	6.7	pKi	=	6.7	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
		CHEMBL29846	108336	1	None	-323	14	Human	6.7	pKi	=	6.7	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
		10838923	59409	0	None	-63	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	494	4	1	6	5.6	Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)C4(CCN(C)CC4)CO5)cc3)c(C)c2)no1	10.1021/jm970457s
		CHEMBL15933	59409	0	None	-63	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	494	4	1	6	5.6	Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)C4(CCN(C)CC4)CO5)cc3)c(C)c2)no1	10.1021/jm970457s
		44343212	16610	0	None	-50	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D (human cloned receptor) in CHO cells using [3H]-5-HT as radioligand.Binding affinity towards 5-hydroxytryptamine 1D (human cloned receptor) in CHO cells using [3H]-5-HT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL114012	16610	0	None	-50	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D (human cloned receptor) in CHO cells using [3H]-5-HT as radioligand.Binding affinity towards 5-hydroxytryptamine 1D (human cloned receptor) in CHO cells using [3H]-5-HT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		44588771	198039	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	431	5	1	6	3.6	Cc1ccc2c(OC3CCN(CC(=O)c4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL519037	198039	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	431	5	1	6	3.6	Cc1ccc2c(OC3CCN(CC(=O)c4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		1534	109817	53	None	-18	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		9287	109817	53	None	-18	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		CHEMBL30713	109817	53	None	-18	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]GR127543 from human recombinant 5-HT1D receptor expressed in HEK293T cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		10385855	21197	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL120055	21197	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL321818	21197	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/S0960-894X(97)10164-0
		11121216	36912	0	None	3	14	Human	8.7	pKi	=	8.7	Binding	Binding affinities towards 5-hydroxytryptamine 1D receptor alphaBinding affinities towards 5-hydroxytryptamine 1D receptor alpha	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL138989	36912	0	None	3	14	Human	8.7	pKi	=	8.7	Binding	Binding affinities towards 5-hydroxytryptamine 1D receptor alphaBinding affinities towards 5-hydroxytryptamine 1D receptor alpha	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		44342783	16591	0	None	6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	436	4	2	2	5.5	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/C4CCCCC4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL113868	16591	0	None	6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	436	4	2	2	5.5	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/C4CCCCC4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		44373641	127017	0	None	10	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	408	7	2	5	2.4	COc1cccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)c1	10.1016/0960-894X(95)00091-7
		CHEMBL352234	127017	0	None	10	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	408	7	2	5	2.4	COc1cccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)c1	10.1016/0960-894X(95)00091-7
		9796492	36755	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	304	4	1	4	2.9	CN(C)CCn1ccc2ccc(C3(O)CCSCC3)cc21	10.1016/j.bmcl.2003.09.025
		CHEMBL138872	36755	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	304	4	1	4	2.9	CN(C)CCn1ccc2ccc(C3(O)CCSCC3)cc21	10.1016/j.bmcl.2003.09.025
		10044965	210947	0	None	-3	4	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	374	8	1	2	5.2	CCCN(CCCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL70680	210947	0	None	-3	4	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	374	8	1	2	5.2	CCCN(CCCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		10406614	211195	0	None	-19	4	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	366	7	1	3	4.9	CCCN(CCc1cccs1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL72062	211195	0	None	-19	4	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	366	7	1	3	4.9	CCCN(CCc1cccs1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		5	6927	72	None	-6	53	Human	8.7	pKi	=	8.7	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm9805945
		5202	6927	72	None	-6	53	Human	8.7	pKi	=	8.7	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm9805945
		CHEMBL39	6927	72	None	-6	53	Human	8.7	pKi	=	8.7	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm9805945
		DB08839	6927	72	None	-6	53	Human	8.7	pKi	=	8.7	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm9805945
		2543	10479	68	None	-1	32	Human	8.7	pKi	=	8.7	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980137o
		5358	10479	68	None	-1	32	Human	8.7	pKi	=	8.7	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980137o
		54	10479	68	None	-1	32	Human	8.7	pKi	=	8.7	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980137o
		CHEMBL128	10479	68	None	-1	32	Human	8.7	pKi	=	8.7	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980137o
		DB00669	10479	68	None	-1	32	Human	8.7	pKi	=	8.7	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm980137o
		10385855	21197	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		CHEMBL120055	21197	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		CHEMBL321818	21197	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1021/jm00018a020
		10385855	21197	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
		CHEMBL120055	21197	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
		CHEMBL321818	21197	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
		10458087	17540	0	None	64	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	485	9	3	6	1.4	CS(=O)(=O)NCc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL117157	17540	0	None	64	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	485	9	3	6	1.4	CS(=O)(=O)NCc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		1043	8363	14	None	-23	29	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2013.12.024
		149	8363	14	None	-23	29	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2013.12.024
		8223	8363	14	None	-23	29	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2013.12.024
		CHEMBL442	8363	14	None	-23	29	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2013.12.024
		DB00696	8363	14	None	-23	29	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2013.12.024
		24881754	195071	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	694	18	4	4	9.9	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL500284	195071	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	694	18	4	4	9.9	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		1884	9512	58	None	3	5	Human	8.6	pKi	=	8.6	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10.1021/jm9805945
		4440	9512	58	None	3	5	Human	8.6	pKi	=	8.6	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10.1021/jm9805945
		45	9512	58	None	3	5	Human	8.6	pKi	=	8.6	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10.1021/jm9805945
		CHEMBL1278	9512	58	None	3	5	Human	8.6	pKi	=	8.6	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10.1021/jm9805945
		DB00952	9512	58	None	3	5	Human	8.6	pKi	=	8.6	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10.1021/jm9805945
		10472143	126055	0	None	-5	16	Human	8.6	pKi	=	8.6	Binding	Binding affinities towards 5-hydroxytryptamine 1D receptor alphaBinding affinities towards 5-hydroxytryptamine 1D receptor alpha	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL343755	126055	0	None	-5	16	Human	8.6	pKi	=	8.6	Binding	Binding affinities towards 5-hydroxytryptamine 1D receptor alphaBinding affinities towards 5-hydroxytryptamine 1D receptor alpha	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		10250834	22207	1	None	83	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	407	7	3	5	1.9	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(CN)cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL121499	22207	1	None	83	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	407	7	3	5	1.9	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(CN)cc4)CC3)cc12	10.1021/jm00018a020
		10403999	66824	0	None	27	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	324	4	1	2	5.3	CC1CCC(C)N1CCc1c[nH]c2ccc(-c3cccs3)cc12	10.1016/s0960-894x(00)00133-5
		CHEMBL173656	66824	0	None	27	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	324	4	1	2	5.3	CC1CCC(C)N1CCc1c[nH]c2ccc(-c3cccs3)cc12	10.1016/s0960-894x(00)00133-5
		11777940	108208	0	None	123	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	270	3	1	1	4.1	CC(C)(C)c1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1016/s0960-894x(00)00322-x
		CHEMBL297471	108208	0	None	123	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	270	3	1	1	4.1	CC(C)(C)c1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1016/s0960-894x(00)00322-x
		10253939	117163	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	465	10	2	6	3.5	NCCc1c[nH]c2ccc(OCCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL324289	117163	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	465	10	2	6	3.5	NCCc1c[nH]c2ccc(OCCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		11740280	109703	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	376	8	1	2	5.4	CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL306197	109703	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	376	8	1	2	5.4	CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		107780	8625	54	None	-1	18	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm970457s
		14	8625	54	None	-1	18	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm970457s
		CHEMBL15928	8625	54	None	-1	18	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm970457s
		10173443	181782	0	None	3	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	429	7	0	4	5.5	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL456684	181782	0	None	3	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	429	7	0	4	5.5	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		10310423	182275	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	445	7	0	5	4.7	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCOCC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL457765	182275	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	445	7	0	5	4.7	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCOCC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		10173169	75426	0	None	100	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(OCCN3CCN(Cc4cccc5ncccc45)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL191921	75426	0	None	100	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(OCCN3CCN(Cc4cccc5ncccc45)CC3)cccc2n1	10.1021/jm049039v
		11235335	130803	0	None	125	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	413	6	0	6	3.7	Cc1ccc2c(OCCN3CCN(Cc4cccc5ncncc45)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL362992	130803	0	None	125	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	413	6	0	6	3.7	Cc1ccc2c(OCCN3CCN(Cc4cccc5ncncc45)CC3)cccc2n1	10.1021/jm049039v
		22326704	151715	0	None	12	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)c(F)ccc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL391033	151715	0	None	12	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)c(F)ccc2n1	10.1016/j.bmcl.2006.11.031
		10114480	100371	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	445	6	0	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		CHEMBL246597	100371	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	445	6	0	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		44443097	100703	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	488	8	0	6	4.1	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(CC(C)C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		CHEMBL248230	100703	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	488	8	0	6	4.1	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(CC(C)C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		10172853	194425	0	None	5	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	391	7	0	5	3.7	COc1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		CHEMBL494992	194425	0	None	5	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	391	7	0	5	3.7	COc1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1	10.1021/jm8001444
		44404236	77331	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	406	2	0	4	3.8	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2Cl)CC4)CC1	10.1016/j.bmcl.2005.06.042
		CHEMBL194809	77331	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	406	2	0	4	3.8	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2Cl)CC4)CC1	10.1016/j.bmcl.2005.06.042
		44404245	78683	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	391	2	0	6	2.8	Cc1nc(C)c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)o1	10.1016/j.bmcl.2005.06.042
		CHEMBL197169	78683	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	391	2	0	6	2.8	Cc1nc(C)c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)o1	10.1016/j.bmcl.2005.06.042
		44404253	142057	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	477	4	1	7	3.5	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCNCC5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		CHEMBL372651	142057	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	477	4	1	7	3.5	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCNCC5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		44404258	172938	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	505	5	0	7	4.2	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(CC)CC5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		CHEMBL426285	172938	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	505	5	0	7	4.2	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(CC)CC5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		1043	8363	14	None	-23	29	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2013.12.024
		149	8363	14	None	-23	29	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2013.12.024
		8223	8363	14	None	-23	29	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2013.12.024
		CHEMBL442	8363	14	None	-23	29	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2013.12.024
		DB00696	8363	14	None	-23	29	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2013.12.024
		10344705	22319	0	None	56	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	471	8	3	6	1.8	CS(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL121901	22319	0	None	56	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	471	8	3	6	1.8	CS(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		10365683	119855	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	435	7	3	5	2.4	CC(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		CHEMBL331240	119855	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	435	7	3	5	2.4	CC(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1	10.1021/jm00018a020
		10518850	41967	0	None	2	4	Human	8.6	pKi	=	8.6	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	308	4	2	4	1.9	NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		CHEMBL143512	41967	0	None	2	4	Human	8.6	pKi	=	8.6	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	308	4	2	4	1.9	NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		10021450	109479	0	None	-70	4	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	360	7	1	2	4.8	CCCN(CCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL304767	109479	0	None	-70	4	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	360	7	1	2	4.8	CCCN(CCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		10340549	121604	0	None	275	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	393	6	3	5	2.0	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL334159	121604	0	None	275	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	393	6	3	5	2.0	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12	10.1021/jm00018a020
		145	6928	49	None	-2	30	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm950498t
		1832	6928	49	None	-2	30	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm950498t
		CHEMBL7257	6928	49	None	-2	30	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm950498t
		DB14010	6928	49	None	-2	30	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm950498t
		44460810	212402	0	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	436	5	1	4	4.9	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2csc3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL81703	212402	0	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	436	5	1	4	4.9	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2csc3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL5094680	222289	0	None	-131	8	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		145964159	171108	0	None	-42	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4212435	171108	0	None	-42	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		4595	183494	106	None	-22	14	Rat	4.7	pKi	=	4.7	Binding	The binding affinity was measured on 5-hydroxytryptamine 1D receptor using [3H]- serotonin as radioligand.The binding affinity was measured on 5-hydroxytryptamine 1D receptor using [3H]- serotonin as radioligand.	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	10.1021/jm00075a026
		CHEMBL46	183494	106	None	-22	14	Rat	4.7	pKi	=	4.7	Binding	The binding affinity was measured on 5-hydroxytryptamine 1D receptor using [3H]- serotonin as radioligand.The binding affinity was measured on 5-hydroxytryptamine 1D receptor using [3H]- serotonin as radioligand.	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	10.1021/jm00075a026
		142601329	193296	5	None	-309	7	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4877603	193296	5	None	-309	7	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		9859280	113111	1	None	-56	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	219	4	1	2	2.6	CNCCOc1cccc(Cl)c1Cl	10.1007/s00044-009-9164-1
		CHEMBL2260920	113111	1	None	-56	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	219	4	1	2	2.6	CNCCOc1cccc(Cl)c1Cl	10.1007/s00044-009-9164-1
		CHEMBL3139165	113111	1	None	-56	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	219	4	1	2	2.6	CNCCOc1cccc(Cl)c1Cl	10.1007/s00044-009-9164-1
		CHEMBL4748908	220814	1	None	-22	12	Human	5.7	pKi	=	5.7	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
		78576	73776	23	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	189	1	2	1	1.5	Cc1cccc(C)c1N=C1NCCN1	10.1016/j.bmcl.2004.06.085
		CHEMBL186919	73776	23	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	189	1	2	1	1.5	Cc1cccc(C)c1N=C1NCCN1	10.1016/j.bmcl.2004.06.085
		44403101	78772	0	None	-32	6	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	485	5	1	5	4.5	COc1ccc(NC(=O)N2CCN(c3ccc(-c4ccccc4)cc3)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL197408	78772	0	None	-32	6	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	485	5	1	5	4.5	COc1ccc(NC(=O)N2CCN(c3ccc(-c4ccccc4)cc3)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		9954663	63298	0	None	20	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	435	6	1	3	4.3	O=S(=O)(c1ccccc1)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1	10.1016/j.bmcl.2003.11.023
		CHEMBL163639	63298	0	None	20	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	435	6	1	3	4.3	O=S(=O)(c1ccccc1)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1	10.1016/j.bmcl.2003.11.023
		10590370	168597	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	300	11	2	1	5.4	CCCCCCCCCCc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		CHEMBL414420	168597	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	300	11	2	1	5.4	CCCCCCCCCCc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		44395809	129882	0	None	-43	4	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	353	3	1	3	3.5	CN1CCC(N2CCc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1	10.1016/j.bmcl.2004.09.079
		CHEMBL361061	129882	0	None	-43	4	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	353	3	1	3	3.5	CN1CCC(N2CCc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1	10.1016/j.bmcl.2004.09.079
		67268994	170747	2	None	-69	7	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4207884	170747	2	None	-69	7	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		127036932	144126	0	None	-7	22	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752900	144126	0	None	-7	22	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		10425027	210991	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	302	5	0	2	4.3	CCCN(CCC)C1CCc2cc(F)c3c(ccn3C)c2C1	10.1021/jm00012a021
		CHEMBL70882	210991	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	302	5	0	2	4.3	CCCN(CCC)C1CCc2cc(F)c3c(ccn3C)c2C1	10.1021/jm00012a021
		24881552	195890	0	None	45	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	700	9	4	4	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL510280	195890	0	None	45	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	700	9	4	4	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		142601337	192749	0	None	-69	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4869695	192749	0	None	-69	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		18007501	126050	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	286	4	0	3	3.7	CN(C)CCn1ccc2ccc(C3=CCSCC3)cc21	10.1016/j.bmcl.2003.09.025
		CHEMBL343712	126050	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	286	4	0	3	3.7	CN(C)CCn1ccc2ccc(C3=CCSCC3)cc21	10.1016/j.bmcl.2003.09.025
		CHEMBL5074880	221118	0	None	-22	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5081379	221525	0	None	-33	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		145963830	170902	0	None	-21	7	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
		CHEMBL4209942	170902	0	None	-21	7	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
		24782016	211018	4	None	-26	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	188	2	1	2	1.8	Cc1cccc(C)c1CC1=NCCN1	10.1016/j.bmcl.2004.06.085
		CHEMBL71033	211018	4	None	-26	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	188	2	1	2	1.8	Cc1cccc(C)c1CC1=NCCN1	10.1016/j.bmcl.2004.06.085
		24782016	211018	4	None	-26	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	188	2	1	2	1.8	Cc1cccc(C)c1CC1=NCCN1	10.1021/jm970513p
		CHEMBL71033	211018	4	None	-26	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	188	2	1	2	1.8	Cc1cccc(C)c1CC1=NCCN1	10.1021/jm970513p
		10498633	170082	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	358	15	2	2	6.2	CCCCCCCCCOc1ccc2[nH]cc(CCNCCCC)c2c1	10.1021/jm950498t
		CHEMBL418823	170082	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	358	15	2	2	6.2	CCCCCCCCCOc1ccc2[nH]cc(CCNCCCC)c2c1	10.1021/jm950498t
		10674647	45750	0	None	-870	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	574	10	2	8	4.1	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(C)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		CHEMBL146815	45750	0	None	-870	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	574	10	2	8	4.1	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(C)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		76312088	112988	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	321	4	1	2	3.2	CNC(C)COc1c(Br)cccc1Br	10.1007/s00044-009-9164-1
		CHEMBL2260929	112988	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	321	4	1	2	3.2	CNC(C)COc1c(Br)cccc1Br	10.1007/s00044-009-9164-1
		CHEMBL3138771	112988	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	321	4	1	2	3.2	CNC(C)COc1c(Br)cccc1Br	10.1007/s00044-009-9164-1
		25067564	208079	0	None	-512	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	392	3	2	5	3.1	N[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		CHEMBL604102	208079	0	None	-512	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	392	3	2	5	3.1	N[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
		14547415	107447	1	None	-1	4	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	214	1	1	1	2.6	CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL292274	107447	1	None	-1	4	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	214	1	1	1	2.6	CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		11779840	109012	0	None	-4	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	304	5	1	1	4.8	CCCN(CCC)C1CCc2ccc3[nH]cc(Cl)c3c2C1	10.1021/jm00012a021
		CHEMBL303021	109012	0	None	-4	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	304	5	1	1	4.8	CCCN(CCC)C1CCc2ccc3[nH]cc(Cl)c3c2C1	10.1021/jm00012a021
		1150	10650	121	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm950498t
		125	10650	121	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm950498t
		CHEMBL6640	10650	121	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm950498t
		DB08653	10650	121	None	-3	25	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm950498t
		10198756	11642	1	None	1	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	245	2	1	3	2.4	COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		CHEMBL104374	11642	1	None	1	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	245	2	1	3	2.4	COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		2543	10479	68	None	-1	32	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
		5358	10479	68	None	-1	32	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
		54	10479	68	None	-1	32	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
		CHEMBL128	10479	68	None	-1	32	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
		DB00669	10479	68	None	-1	32	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
		19066200	18153	0	None	-27	3	Human	6.6	pKi	=	6.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	439	5	1	6	2.8	COc1ccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)cc1	10.1016/S0960-894X(97)10164-0
		CHEMBL108645	18153	0	None	-27	3	Human	6.6	pKi	=	6.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	439	5	1	6	2.8	COc1ccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)cc1	10.1016/S0960-894X(97)10164-0
		CHEMBL1179985	18153	0	None	-27	3	Human	6.6	pKi	=	6.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	439	5	1	6	2.8	COc1ccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)cc1	10.1016/S0960-894X(97)10164-0
		44395810	73101	0	None	-4	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	369	3	1	4	3.4	CN1CCC(N2CCOc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1	10.1016/j.bmcl.2004.09.079
		CHEMBL184994	73101	0	None	-4	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	369	3	1	4	3.4	CN1CCC(N2CCOc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1	10.1016/j.bmcl.2004.09.079
		44395762	74008	0	None	-257	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	353	3	2	3	3.9	CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1	10.1016/j.bmcl.2004.09.079
		CHEMBL187952	74008	0	None	-257	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	353	3	2	3	3.9	CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1	10.1016/j.bmcl.2004.09.079
		136152971	102132	0	None	-128	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	293	2	2	3	3.5	C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL256694	102132	0	None	-128	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	293	2	2	3	3.5	C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL4777443	220825	0	None	-11	14	Human	6.6	pKi	=	6.6	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR1DSelectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR1D	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1	10.6019/CHEMBL5212743
		73346042	98609	5	None	-2344	17	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		CHEMBL2413153	98609	5	None	-2344	17	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		10496545	16099	0	None	-13	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound against 5-HT1Dalpha Binding affinity of compound against 5-HT1D alpha receptors in humanBinding affinity of compound against 5-HT1Dalpha Binding affinity of compound against 5-HT1D alpha receptors in human	ChEMBL	328	9	2	2	5.1	CCCCCCCCCOc1ccc2[nH]c3c(c2c1)CC(N)CC3	10.1021/jm950498t
		CHEMBL111107	16099	0	None	-13	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound against 5-HT1Dalpha Binding affinity of compound against 5-HT1D alpha receptors in humanBinding affinity of compound against 5-HT1Dalpha Binding affinity of compound against 5-HT1D alpha receptors in human	ChEMBL	328	9	2	2	5.1	CCCCCCCCCOc1ccc2[nH]c3c(c2c1)CC(N)CC3	10.1021/jm950498t
		71450247	89751	0	None	-467	9	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human 5HT1D by Cerep protocol based assayBinding affinity to human 5HT1D by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
		CHEMBL2181188	89751	0	None	-467	9	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human 5HT1D by Cerep protocol based assayBinding affinity to human 5HT1D by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
		10536129	211371	1	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	202	4	1	2	2.2	CCCc1ccc(CC2=NCCN2)cc1	10.1021/jm970513p
		CHEMBL73190	211371	1	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	202	4	1	2	2.2	CCCc1ccc(CC2=NCCN2)cc1	10.1021/jm970513p
		10692095	211171	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	395	6	1	5	2.6	COc1ccc(N2CCN(CC[C@H]3OCCc4cc(C(N)=O)ccc43)CC2)cc1	10.1021/jm980137o
		CHEMBL71907	211171	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	395	6	1	5	2.6	COc1ccc(N2CCN(CC[C@H]3OCCc4cc(C(N)=O)ccc43)CC2)cc1	10.1021/jm980137o
		9888494	104947	0	None	-1071	13	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		CHEMBL273921	104947	0	None	-1071	13	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
		44461297	176045	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	420	5	2	4	3.6	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2[nH]nc3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL441259	176045	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	420	5	2	4	3.6	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2[nH]nc3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		24881550	179525	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	726	10	4	4	9.0	O=C(Nc1ccc2[nH]cc(C3CCN(C/C=C/CN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL450852	179525	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	726	10	4	4	9.0	O=C(Nc1ccc2[nH]cc(C3CCN(C/C=C/CN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		10267412	211131	0	None	-39	4	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	310	6	1	2	4.0	CCCN(CC1CC1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL71640	211131	0	None	-39	4	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	310	6	1	2	4.0	CCCN(CC1CC1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		44337731	18151	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	442	5	0	5	3.1	Cc1ccccc1N1CCN(C(=O)COc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL106807	18151	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	442	5	0	5	3.1	Cc1ccccc1N1CCN(C(=O)COc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL1179968	18151	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	442	5	0	5	3.1	Cc1ccccc1N1CCN(C(=O)COc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1	10.1016/S0960-894X(97)10164-0
		10430183	212407	0	None	-251	7	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5-HT1D receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human 5-HT1D receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.2c00633
		CHEMBL81728	212407	0	None	-251	7	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5-HT1D receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human 5-HT1D receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.2c00633
		46905266	16946	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCO[C@@H]2CCN1CC=C(c2c[nH]c3c(F)cccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL1159649	16946	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCO[C@@H]2CCN1CC=C(c2c[nH]c3c(F)cccc23)CC1	10.1016/j.bmcl.2004.03.003
		44402876	77663	0	None	-12	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	492	4	0	5	5.2	COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL195114	77663	0	None	-12	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	492	4	0	5	5.2	COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2	10.1016/j.bmcl.2005.07.085
		44402884	142070	0	None	-10	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	497	3	0	5	5.5	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Oc1cccc(C(F)(F)F)c1Cl)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL372731	142070	0	None	-10	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	497	3	0	5	5.5	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Oc1cccc(C(F)(F)F)c1Cl)CC2	10.1016/j.bmcl.2005.07.085
		10577268	89164	0	None	-15	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	498	8	1	7	5.1	Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4cc5c(c(OCCN(C)C)c4)OCC5)cc3)c(C)c2)no1	10.1021/jm970457s
		CHEMBL21724	89164	0	None	-15	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	498	8	1	7	5.1	Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4cc5c(c(OCCN(C)C)c4)OCC5)cc3)c(C)c2)no1	10.1021/jm970457s
		10028436	10305	5	None	-12	12	Human	7.6	pKi	=	7.6	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 1D receptor in CHO using [3H]5-HT as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 1D receptor in CHO using [3H]5-HT as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
		3237	10305	5	None	-12	12	Human	7.6	pKi	=	7.6	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 1D receptor in CHO using [3H]5-HT as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 1D receptor in CHO using [3H]5-HT as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
		CHEMBL95104	10305	5	None	-12	12	Human	7.6	pKi	=	7.6	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 1D receptor in CHO using [3H]5-HT as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 1D receptor in CHO using [3H]5-HT as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
		44580783	199939	0	None	-31	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	414	4	1	5	3.4	Cc1ccc2c(N3C[C@H]4C[C@@H]3CN4CCc3ccc4c(c3)NC(=O)CO4)cccc2n1	10.1016/j.bmcl.2008.08.084
		CHEMBL523064	199939	0	None	-31	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	414	4	1	5	3.4	Cc1ccc2c(N3C[C@H]4C[C@@H]3CN4CCc3ccc4c(c3)NC(=O)CO4)cccc2n1	10.1016/j.bmcl.2008.08.084
		49756	211091	13	None	-3	8	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm990550b
		CHEMBL7143	211091	13	None	-3	8	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm990550b
		10049500	84596	0	None	-165	4	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	451	9	1	4	4.5	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL2092864	84596	0	None	-165	4	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	451	9	1	4	4.5	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL2112317	84596	0	None	-165	4	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	451	9	1	4	4.5	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		10445946	174642	4	None	-50	4	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	272	2	2	3	2.3	CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		CHEMBL431041	174642	4	None	-50	4	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	272	2	2	3	2.3	CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		22132555	20480	0	None	-19	4	Human	6.6	pKi	=	6.6	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	398	7	2	3	4.0	N#Cc1ccc2c(c1)CN(CCCCNC(=O)/C=C/c1c[nH]c3ccccc13)CC2	10.1021/jm000090i
		CHEMBL1194956	20480	0	None	-19	4	Human	6.6	pKi	=	6.6	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	398	7	2	3	4.0	N#Cc1ccc2c(c1)CN(CCCCNC(=O)/C=C/c1c[nH]c3ccccc13)CC2	10.1021/jm000090i
		CHEMBL553591	20480	0	None	-19	4	Human	6.6	pKi	=	6.6	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	398	7	2	3	4.0	N#Cc1ccc2c(c1)CN(CCCCNC(=O)/C=C/c1c[nH]c3ccccc13)CC2	10.1021/jm000090i
		44402875	77229	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	413	3	0	4	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1cccc(Cl)c1)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL194610	77229	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	413	3	0	4	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1cccc(Cl)c1)CC2	10.1016/j.bmcl.2005.07.085
		11591924	78533	3	None	-79	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	537	5	1	7	5.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL196666	78533	3	None	-79	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	537	5	1	7	5.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		69836292	85793	0	None	-15	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	438	5	0	6	3.3	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc([N+](=O)[O-])c1)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL2113098	85793	0	None	-15	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	438	5	0	6	3.3	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc([N+](=O)[O-])c1)CC2	10.1016/j.bmcl.2005.07.085
		44402895	131330	0	None	-50	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	533	5	1	6	5.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4ncccn4)cc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL364056	131330	0	None	-50	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	533	5	1	6	5.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4ncccn4)cc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		44402874	140324	0	None	-19	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	447	3	0	4	4.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1cccc(Cl)c1Cl)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL370896	140324	0	None	-19	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	447	3	0	4	4.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1cccc(Cl)c1Cl)CC2	10.1016/j.bmcl.2005.07.085
		9891618	113901	0	None	-251	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	486	4	1	6	5.0	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
		CHEMBL316081	113901	0	None	-251	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	486	4	1	6	5.0	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
		276	10286	50	None	-169	13	Human	6.6	pKi	=	6.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
		5312149	10286	50	None	-169	13	Human	6.6	pKi	=	6.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
		CHEMBL431298	10286	50	None	-169	13	Human	6.6	pKi	=	6.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
		6918647	107522	2	None	-50	14	Human	6.6	pKi	=	6.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
		CHEMBL292759	107522	2	None	-50	14	Human	6.6	pKi	=	6.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
		9934284	97071	0	None	-630	10	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238520	97071	0	None	-630	10	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		22326660	97546	0	None	-12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	456	6	1	6	4.1	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(C#N)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL239167	97546	0	None	-12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	456	6	1	6	4.1	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(C#N)cc2n1	10.1016/j.bmcl.2006.11.031
		44593711	191102	0	None	-5	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	445	6	1	5	4.6	Cc1ccc2c(OCC(C)N3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL484216	191102	0	None	-5	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	445	6	1	5	4.6	Cc1ccc2c(OCC(C)N3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		44588772	191899	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	445	6	1	6	3.8	Cc1ccc2c(OCC3CCN(CC(=O)c4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL485630	191899	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	445	6	1	6	3.8	Cc1ccc2c(OCC3CCN(CC(=O)c4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		44588742	198028	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	419	7	1	6	3.4	Cc1ccc2c(OCCCN3CC(Oc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL519019	198028	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	419	7	1	6	3.4	Cc1ccc2c(OCCCN3CC(Oc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1	10.1016/j.bmcl.2008.08.110
		276	10286	50	None	-169	13	Human	6.6	pKi	=	6.6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
		5312149	10286	50	None	-169	13	Human	6.6	pKi	=	6.6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
		CHEMBL431298	10286	50	None	-169	13	Human	6.6	pKi	=	6.6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
		9870053	215063	0	None	-1995	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	486	5	2	6	4.9	CCc1c(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
		CHEMBL98965	215063	0	None	-1995	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	486	5	2	6	4.9	CCc1c(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
		10127209	75433	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	429	6	0	4	5.0	Cc1ccc2c(OCCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL191980	75433	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	429	6	0	4	5.0	Cc1ccc2c(OCCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)cccc2n1	10.1021/jm049039v
		10488933	211469	1	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	216	5	1	2	2.6	CCCCc1ccc(CC2=NCCN2)cc1	10.1021/jm970513p
		CHEMBL73943	211469	1	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	216	5	1	2	2.6	CCCCc1ccc(CC2=NCCN2)cc1	10.1021/jm970513p
		142601333	192542	0	None	-109	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4866412	192542	0	None	-109	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		136118658	83029	0	None	-2	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cellsDisplacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058426	83029	0	None	-2	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cellsDisplacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
		71461049	89750	0	None	-151	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human 5HT1D by Cerep protocol based assayBinding affinity to human 5HT1D by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
		CHEMBL2181187	89750	0	None	-151	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human 5HT1D by Cerep protocol based assayBinding affinity to human 5HT1D by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
		10434550	18871	0	None	-52	3	Human	7.6	pKi	=	7.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	463	4	1	5	3.7	COc1ccc(NC(=O)N2CCN(c3cccc4c3CCCC4)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL1183948	18871	0	None	-52	3	Human	7.6	pKi	=	7.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	463	4	1	5	3.7	COc1ccc(NC(=O)N2CCN(c3cccc4c3CCCC4)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL325359	18871	0	None	-52	3	Human	7.6	pKi	=	7.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	463	4	1	5	3.7	COc1ccc(NC(=O)N2CCN(c3cccc4c3CCCC4)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		10016864	211027	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	286	5	1	2	3.2	CCCN(CCC)C1CCc2ccc3c(c2C1)CC(=O)N3	10.1021/jm00012a021
		CHEMBL71091	211027	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	286	5	1	2	3.2	CCCN(CCC)C1CCc2ccc3c(c2C1)CC(=O)N3	10.1021/jm00012a021
		44461335	212571	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3c(F)cccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL83112	212571	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3c(F)cccc23)CC1	10.1016/j.bmcl.2004.03.003
		44461425	212638	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	430	5	1	3	4.9	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2cccc3ccc(F)cc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL83732	212638	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	430	5	1	3	4.9	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2cccc3ccc(F)cc23)CC1	10.1016/j.bmcl.2004.03.003
		11743042	210829	0	None	-13	4	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	423	8	1	3	4.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL69943	210829	0	None	-13	4	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	423	8	1	3	4.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		130	10273	47	None	-120	13	Human	6.6	pKi	=	6.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/S0960-894X(97)10164-0
		3378093	10273	47	None	-120	13	Human	6.6	pKi	=	6.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/S0960-894X(97)10164-0
		CHEMBL281350	10273	47	None	-120	13	Human	6.6	pKi	=	6.6	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1016/S0960-894X(97)10164-0
		16093484	104836	6	None	-131	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL273170	104836	6	None	-131	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
		9886269	34352	1	None	-131	4	Human	5.6	pKi	=	5.6	Binding	Affinity at 5-hydroxytryptamine 1D receptor from calf caudate using [3H]5-HT as radioligand (For sumatriptan = Ki(nM)-12+/-1.9)Affinity at 5-hydroxytryptamine 1D receptor from calf caudate using [3H]5-HT as radioligand (For sumatriptan = Ki(nM)-12+/-1.9)	ChEMBL	382	6	1	5	4.2	COc1ccccc1N1CCN(CCC(O)c2csc3ccccc23)CC1	10.1021/jm001059j
		CHEMBL136936	34352	1	None	-131	4	Human	5.6	pKi	=	5.6	Binding	Affinity at 5-hydroxytryptamine 1D receptor from calf caudate using [3H]5-HT as radioligand (For sumatriptan = Ki(nM)-12+/-1.9)Affinity at 5-hydroxytryptamine 1D receptor from calf caudate using [3H]5-HT as radioligand (For sumatriptan = Ki(nM)-12+/-1.9)	ChEMBL	382	6	1	5	4.2	COc1ccccc1N1CCN(CCC(O)c2csc3ccccc23)CC1	10.1021/jm001059j
		752521	205516	8	None	-128	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
		CHEMBL582877	205516	8	None	-128	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
		9802224	85387	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	420	5	1	4	4.5	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2ccc(F)c3ccoc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL2112307	85387	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	420	5	1	4	4.5	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2ccc(F)c3ccoc23)CC1	10.1016/j.bmcl.2004.03.003
		44376491	62264	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	485	6	1	3	5.4	O=S(=O)(c1cccc2ccccc12)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1	10.1016/j.bmcl.2003.11.023
		CHEMBL162011	62264	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	485	6	1	3	5.4	O=S(=O)(c1cccc2ccccc12)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1	10.1016/j.bmcl.2003.11.023
		10400189	112432	0	None	-26	4	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	256	4	2	2	2.8	CCCNC1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL312525	112432	0	None	-26	4	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	256	4	2	2	2.8	CCCNC1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		44568347	198430	0	None	-128	15	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at serotonin 5HT1D receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT1D receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL519609	198430	0	None	-128	15	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at serotonin 5HT1D receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT1D receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		145978665	170297	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	246	2	2	3	2.4	C[C@@H]1SC(c2c[nH]c3ccccc23)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4202582	170297	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	246	2	2	3	2.4	C[C@@H]1SC(c2c[nH]c3ccccc23)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		44554395	25495	0	None	-1737	7	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human cloned 5HT1D receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT1D receptor expressed in human HeLa cells	ChEMBL	406	3	1	6	3.0	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
		CHEMBL1277565	25495	0	None	-1737	7	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human cloned 5HT1D receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT1D receptor expressed in human HeLa cells	ChEMBL	406	3	1	6	3.0	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
		10506674	126502	0	None	-954	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	542	9	3	7	3.4	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		CHEMBL347559	126502	0	None	-954	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	542	9	3	7	3.4	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		122483292	144889	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3764335	144889	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		CHEMBL3765876	144889	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
		44461234	112184	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	435	5	2	3	4.7	C[C@H]1CC(c2c[nH]c3cc(F)ccc23)CCN1CCC1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2004.03.003
		CHEMBL311787	112184	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	435	5	2	3	4.7	C[C@H]1CC(c2c[nH]c3cc(F)ccc23)CCN1CCC1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2004.03.003
		44461298	212494	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	420	5	1	4	4.5	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2coc3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL82488	212494	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	420	5	1	4	4.5	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2coc3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		73213195	111236	0	None	1	12	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	111236	0	None	1	12	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL4576555	220796	5	None	-2	19	Human	5.6	pKi	=	5.6	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		49783419	24521	0	None	-8709	12	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5-HT1D receptorBinding affinity to human 5-HT1D receptor	ChEMBL	366	6	1	6	2.8	CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258671	24521	0	None	-8709	12	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5-HT1D receptorBinding affinity to human 5-HT1D receptor	ChEMBL	366	6	1	6	2.8	CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1	10.1021/jm100668r
		76330157	113024	0	None	1	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	233	4	1	2	3.0	CNC(C)COc1ccc(Cl)cc1Cl	10.1007/s00044-009-9164-1
		CHEMBL2260926	113024	0	None	1	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	233	4	1	2	3.0	CNC(C)COc1ccc(Cl)cc1Cl	10.1007/s00044-009-9164-1
		CHEMBL3138918	113024	0	None	1	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	233	4	1	2	3.0	CNC(C)COc1ccc(Cl)cc1Cl	10.1007/s00044-009-9164-1
		10769499	50990	0	None	-489	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	576	10	3	8	3.6	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(=O)O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		CHEMBL151668	50990	0	None	-489	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	576	10	3	8	3.6	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(=O)O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		44376494	63036	0	None	4	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	420	6	2	3	4.5	O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C1CCCCC1	10.1016/j.bmcl.2003.11.023
		CHEMBL162771	63036	0	None	4	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	420	6	2	3	4.5	O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C1CCCCC1	10.1016/j.bmcl.2003.11.023
		44376283	63282	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	488	6	2	3	5.9	S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C12CC3CC(CC(C3)C1)C2	10.1016/j.bmcl.2003.11.023
		CHEMBL163516	63282	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	488	6	2	3	5.9	S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C12CC3CC(CC(C3)C1)C2	10.1016/j.bmcl.2003.11.023
		44376278	175883	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	472	6	2	3	5.1	O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C12CC3CC(CC(C3)C1)C2	10.1016/j.bmcl.2003.11.023
		CHEMBL440008	175883	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	472	6	2	3	5.1	O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C12CC3CC(CC(C3)C1)C2	10.1016/j.bmcl.2003.11.023
		73213195	111236	0	None	1	12	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	111236	0	None	1	12	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		11200511	208509	0	None	-29	8	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cellsInhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12	10.1021/jm049243i
		CHEMBL606547	208509	0	None	-29	8	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cellsInhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12	10.1021/jm049243i
		12	8335	17	None	-12	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
		6918513	8335	17	None	-12	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
		CHEMBL267615	8335	17	None	-12	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
		118464420	145023	0	None	-489	8	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
		CHEMBL3770342	145023	0	None	-489	8	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
		10401862	109448	1	None	-79	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	288	5	1	1	4.3	CCCN(CCC)[C@H]1CCc2cc(F)c3[nH]ccc3c2C1	10.1021/jm00012a021
		CHEMBL304573	109448	1	None	-79	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	288	5	1	1	4.3	CCCN(CCC)[C@H]1CCc2cc(F)c3[nH]ccc3c2C1	10.1021/jm00012a021
		CHEMBL4534980	220766	20	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000345a HTR1DSelectivity interaction (GPCR panel (PDSP screen)) EUB0000345a HTR1D	ChEMBL		None	None	None		CN(C)[C@H]1CCN(c2cc(-c3ccccc3)nc3ccnn23)C1	10.6019/CHEMBL5212743
		10621491	211159	8	None	-1	3	Human	6.5	pKi	=	6.5	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@@H]2CCN1CCN(c2ccc(OC)cc2)CC1	10.1021/jm980137o
		CHEMBL71798	211159	8	None	-1	3	Human	6.5	pKi	=	6.5	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	409	6	1	5	2.9	CNC(=O)c1ccc2c(c1)CCO[C@@H]2CCN1CCN(c2ccc(OC)cc2)CC1	10.1021/jm980137o
		44342705	116891	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	420	4	2	2	4.9	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC4CCCCC4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL323603	116891	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	420	4	2	2	4.9	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC4CCCCC4)CC3)cc12	10.1016/s0960-894x(03)00779-0
		5	6927	72	None	-6	53	Human	8.5	pKi	=	8.5	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00164a046
		5202	6927	72	None	-6	53	Human	8.5	pKi	=	8.5	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00164a046
		CHEMBL39	6927	72	None	-6	53	Human	8.5	pKi	=	8.5	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00164a046
		DB08839	6927	72	None	-6	53	Human	8.5	pKi	=	8.5	Binding	Binding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenateBinding affinity was determined against 5-hydroxytryptamine 1D receptor in bovine caudate homogenate	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00164a046
		44581235	183795	0	None	2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	521	8	0	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCN(S(C)(=O)=O)CC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL462915	183795	0	None	2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	521	8	0	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCN(S(C)(=O)=O)CC5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		10216160	74369	0	None	125	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	6	1	4	4.2	Cc1ccc2c(OCCN3CCN(Cc4cccc5cc[nH]c45)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL190190	74369	0	None	125	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	6	1	4	4.2	Cc1ccc2c(OCCN3CCN(Cc4cccc5cc[nH]c45)CC3)cccc2n1	10.1021/jm049039v
		10194297	85764	0	None	50	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	6	1	4	4.2	Cc1ccc2c(OCCN3CCN(Cc4ccc5[nH]ccc5c4)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL2113061	85764	0	None	50	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	400	6	1	4	4.2	Cc1ccc2c(OCCN3CCN(Cc4ccc5[nH]ccc5c4)CC3)cccc2n1	10.1021/jm049039v
		10161028	97547	0	None	-6	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL239168	97547	0	None	-6	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2006.11.031
		44443096	100702	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	488	9	0	6	4.3	CCCCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21	10.1016/j.bmcl.2007.06.078
		CHEMBL248229	100702	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	488	9	0	6	4.3	CCCCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21	10.1016/j.bmcl.2007.06.078
		107780	8625	54	None	-3	18	Guinea pig	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm00041a001
		14	8625	54	None	-3	18	Guinea pig	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm00041a001
		CHEMBL15928	8625	54	None	-3	18	Guinea pig	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm00041a001
		10250531	211198	0	None	-	1	Guinea pig	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	402	5	1	5	3.8	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1N1CCN(C)CC1	10.1021/jm00041a001
		CHEMBL72088	211198	0	None	-	1	Guinea pig	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	402	5	1	5	3.8	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1N1CCN(C)CC1	10.1021/jm00041a001
		10346019	211404	0	None	-	1	Guinea pig	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	504	12	1	6	5.2	COCCOC(=O)c1ccc(-c2ccc(NC(=O)c3ccc(OC)c(CCCN(C)C)c3)cc2)c(C)c1	10.1021/jm00041a001
		CHEMBL73446	211404	0	None	-	1	Guinea pig	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	504	12	1	6	5.2	COCCOC(=O)c1ccc(-c2ccc(NC(=O)c3ccc(OC)c(CCCN(C)C)c3)cc2)c(C)c1	10.1021/jm00041a001
		44404272	147669	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	517	4	0	7	4.3	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		CHEMBL382078	147669	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	517	4	0	7	4.3	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		10016747	67072	0	None	40	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	284	4	1	2	4.3	Cc1ccc(-c2ccc3[nH]cc(CCN(C)C)c3c2)s1	10.1016/s0960-894x(00)00133-5
		CHEMBL174355	67072	0	None	40	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	284	4	1	2	4.3	Cc1ccc(-c2ccc3[nH]cc(CCN(C)C)c3c2)s1	10.1016/s0960-894x(00)00133-5
		9802530	42160	1	None	2	4	Human	8.5	pKi	=	8.5	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	336	5	1	4	2.5	CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		CHEMBL143767	42160	1	None	2	4	Human	8.5	pKi	=	8.5	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	336	5	1	4	2.5	CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12	10.1021/jm9604890
		CHEMBL5091373	222346	0	None	-1	9	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5095981	222346	0	None	-1	9	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5077293	221270	0	None	-1	9	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
		2543	10479	68	None	-1	32	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(03)00779-0
		5358	10479	68	None	-1	32	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(03)00779-0
		54	10479	68	None	-1	32	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(03)00779-0
		CHEMBL128	10479	68	None	-1	32	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(03)00779-0
		DB00669	10479	68	None	-1	32	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(03)00779-0
		2543	10479	68	None	-1	32	Human	8.5	pKi	=	8.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.bmcl.2003.11.023
		5358	10479	68	None	-1	32	Human	8.5	pKi	=	8.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.bmcl.2003.11.023
		54	10479	68	None	-1	32	Human	8.5	pKi	=	8.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.bmcl.2003.11.023
		CHEMBL128	10479	68	None	-1	32	Human	8.5	pKi	=	8.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.bmcl.2003.11.023
		DB00669	10479	68	None	-1	32	Human	8.5	pKi	=	8.5	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.bmcl.2003.11.023
		9817415	37694	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	288	4	1	4	2.2	CN(C)CCn1ccc2ccc(C3(O)CCOCC3)cc21	10.1016/j.bmcl.2003.09.025
		CHEMBL139801	37694	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	288	4	1	4	2.2	CN(C)CCn1ccc2ccc(C3(O)CCOCC3)cc21	10.1016/j.bmcl.2003.09.025
		24881201	193628	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	526	6	4	4	5.2	CN1CCC(c2c[nH]c3ccc(NC(=O)CC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		CHEMBL489453	193628	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	526	6	4	4	5.2	CN1CCC(c2c[nH]c3ccc(NC(=O)CC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	10.1021/jm7011722
		10069802	109655	0	None	-2	4	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	404	9	1	3	5.2	CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL305837	109655	0	None	-2	4	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	404	9	1	3	5.2	CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		4202024	45957	5	None	-	1	Human	8.5	pKi	=	8.5	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	242	3	2	1	3.7	NCCc1c[nH]c2ccc(C3CCCCC3)cc12	10.1021/jm9805945
		CHEMBL146976	45957	5	None	-	1	Human	8.5	pKi	=	8.5	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	242	3	2	1	3.7	NCCc1c[nH]c2ccc(C3CCCCC3)cc12	10.1021/jm9805945
		44292367	108646	0	None	33	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	228	2	1	1	3.1	Cc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1016/s0960-894x(00)00322-x
		CHEMBL300686	108646	0	None	33	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	228	2	1	1	3.1	Cc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1016/s0960-894x(00)00322-x
		10048252	18152	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	428	3	0	5	3.7	Cc1ccccc1N1CCN(C(=O)Oc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL107772	18152	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	428	3	0	5	3.7	Cc1ccccc1N1CCN(C(=O)Oc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL1179973	18152	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	428	3	0	5	3.7	Cc1ccccc1N1CCN(C(=O)Oc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1	10.1016/S0960-894X(97)10164-0
		10947658	35475	0	None	-3	16	Human	8.4	pKi	=	8.4	Binding	Binding affinities against 5-hydroxytryptamine 1D receptor alphaBinding affinities against 5-hydroxytryptamine 1D receptor alpha	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL137781	35475	0	None	-3	16	Human	8.4	pKi	=	8.4	Binding	Binding affinities against 5-hydroxytryptamine 1D receptor alphaBinding affinities against 5-hydroxytryptamine 1D receptor alpha	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		18007586	125960	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	272	4	0	3	3.1	CN(C)CCn1ccc2ccc(C3CCOCC3)cc21	10.1016/j.bmcl.2003.09.025
		CHEMBL343105	125960	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	272	4	0	3	3.1	CN(C)CCn1ccc2ccc(C3CCOCC3)cc21	10.1016/j.bmcl.2003.09.025
		188006	12240	14	None	2	3	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	188	3	2	1	2.2	CCc1ccc2[nH]cc(CCN)c2c1	10.1021/jm9805945
		CHEMBL107511	12240	14	None	2	3	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	188	3	2	1	2.2	CCc1ccc2[nH]cc(CCN)c2c1	10.1021/jm9805945
		10970604	11835	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	367	3	3	3	4.2	CN1CCC(c2c[nH]c3ccc(NC(=O)Nc4ccc(F)cc4)nc23)CC1	10.1021/jm030020m
		CHEMBL105369	11835	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	367	3	3	3	4.2	CN1CCC(c2c[nH]c3ccc(NC(=O)Nc4ccc(F)cc4)nc23)CC1	10.1021/jm030020m
		10620719	211129	0	None	64	5	Human	8.4	pKi	=	8.4	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	395	6	1	5	2.6	COc1ccc(N2CCN(CC[C@@H]3OCCc4cc(C(N)=O)ccc43)CC2)cc1	10.1021/jm980137o
		CHEMBL71635	211129	0	None	64	5	Human	8.4	pKi	=	8.4	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	395	6	1	5	2.6	COc1ccc(N2CCN(CC[C@@H]3OCCc4cc(C(N)=O)ccc43)CC2)cc1	10.1021/jm980137o
		1621	9207	17	None	-25	44	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		17	9207	17	None	-25	44	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		5761	9207	17	None	-25	44	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		CHEMBL263881	9207	17	None	-25	44	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		DB04829	9207	17	None	-25	44	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		10076876	108489	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	576	19	0	4	8.7	CCCN(CCC)C1CCc2cccc(OCCCCCCOc3cccc4c3CC(N(CCC)CCC)CC4)c2C1	10.1016/s0960-894x(98)00222-4
		CHEMBL29951	108489	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	576	19	0	4	8.7	CCCN(CCC)C1CCc2cccc(OCCCCCCOc3cccc4c3CC(N(CCC)CCC)CC4)c2C1	10.1016/s0960-894x(98)00222-4
		24881686	195168	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	832	18	4	7	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL501645	195168	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	832	18	4	7	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		10238762	181691	0	None	5	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	472	7	0	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)CC5=O)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL456458	181691	0	None	5	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	472	7	0	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)CC5=O)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		44581604	182838	0	None	3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	485	7	0	4	5.6	CC(=O)N1CCC(c2cccc(CC3CCN(CCOc4cccc5nc(C)ccc45)CC3)c2)CC1	10.1016/j.bmcl.2008.11.052
		CHEMBL459068	182838	0	None	3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	485	7	0	4	5.6	CC(=O)N1CCC(c2cccc(CC3CCN(CCOc4cccc5nc(C)ccc45)CC3)c2)CC1	10.1016/j.bmcl.2008.11.052
		10238160	130971	0	None	19	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	429	6	0	4	5.0	Cc1ccc2c(OCCN3CCN(Cc4cc(Cl)ccc4Cl)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL363413	130971	0	None	19	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	429	6	0	4	5.0	Cc1ccc2c(OCCN3CCN(Cc4cc(Cl)ccc4Cl)CC3)cccc2n1	10.1021/jm049039v
		10183895	100744	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	473	7	0	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)N(C(C)C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		CHEMBL248456	100744	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	473	7	0	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)N(C(C)C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		44404241	140222	1	None	-5	3	Human	8.4	pKi	=	8.4	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	423	2	0	5	3.7	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cccc3ncccc23)CC4)CC1	10.1016/j.bmcl.2005.06.042
		CHEMBL370625	140222	1	None	-5	3	Human	8.4	pKi	=	8.4	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	423	2	0	5	3.7	CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cccc3ncccc23)CC4)CC1	10.1016/j.bmcl.2005.06.042
		9949568	130208	0	None	61	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	334	4	0	2	5.1	Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1Cc1ccccc1	10.1016/j.bmcl.2004.06.085
		CHEMBL361729	130208	0	None	61	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	334	4	0	2	5.1	Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1Cc1ccccc1	10.1016/j.bmcl.2004.06.085
		11101187	115238	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	389	4	1	5	3.3	CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(F)cc4)nc23)CC1	10.1021/jm030020m
		CHEMBL319920	115238	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	389	4	1	5	3.3	CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(F)cc4)nc23)CC1	10.1021/jm030020m
		142601318	192324	0	None	-20	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4863036	192324	0	None	-20	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		10646816	50155	0	None	-7	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	441	8	3	6	2.3	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCCCC2)=C(C)N1	10.1021/jm980506g
		CHEMBL150743	50155	0	None	-7	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	441	8	3	6	2.3	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCCCC2)=C(C)N1	10.1021/jm980506g
		CHEMBL4576555	220796	5	None	-2	19	Human	5.5	pKi	=	5.5	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		10870264	211127	1	None	-57	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	298	6	1	2	4.0	CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		CHEMBL71625	211127	1	None	-57	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	298	6	1	2	4.0	CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		44383728	172125	1	None	15	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	330	4	1	2	5.2	Clc1ccc(-c2ccc3[nH]cc(CCN4CCCC4)c3c2)s1	10.1016/s0960-894x(00)00133-5
		CHEMBL423610	172125	1	None	15	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	330	4	1	2	5.2	Clc1ccc(-c2ccc3[nH]cc(CCN4CCCC4)c3c2)s1	10.1016/s0960-894x(00)00133-5
		15480709	16080	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	246	4	1	3	2.2	CC(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm950498t
		CHEMBL111000	16080	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	246	4	1	3	2.2	CC(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm950498t
		44461306	212710	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	431	6	2	4	4.1	COc1ccc2[nH]cc(C3=CCN(CCC4OCCc5cc(C(N)=O)ccc54)CC3)c2c1	10.1016/j.bmcl.2004.03.003
		CHEMBL84171	212710	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	431	6	2	4	4.1	COc1ccc2[nH]cc(C3=CCN(CCC4OCCc5cc(C(N)=O)ccc54)CC3)c2c1	10.1016/j.bmcl.2004.03.003
		168268877	196749	0	None	-6	12	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		CHEMBL5170784	196749	0	None	-6	12	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
		44402883	78792	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	481	3	0	5	4.9	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Oc1cccc(C(F)(F)F)c1F)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL197505	78792	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	481	3	0	5	4.9	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Oc1cccc(C(F)(F)F)c1F)CC2	10.1016/j.bmcl.2005.07.085
		71458050	85792	0	None	-3	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	410	5	0	6	2.5	COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)Cc1cccc([N+](=O)[O-])c1)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL2113097	85792	0	None	-3	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	410	5	0	6	2.5	COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)Cc1cccc([N+](=O)[O-])c1)CC2	10.1016/j.bmcl.2005.07.085
		28	10269	46	None	-13	10	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm970457s
		3292447	10269	46	None	-13	10	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm970457s
		CHEMBL20963	10269	46	None	-13	10	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm970457s
		44330218	114027	1	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	373	3	2	4	3.5	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccccc1Cl)[C@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL316885	114027	1	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	373	3	2	4	3.5	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccccc1Cl)[C@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		44330281	114141	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	391	3	2	4	3.7	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccc(F)cc1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL317732	114141	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	391	3	2	4	3.7	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccc(F)cc1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		44330148	215117	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	441	3	2	4	4.9	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cc(Cl)cc(Cl)c1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL99341	215117	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	441	3	2	4	4.9	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cc(Cl)cc(Cl)c1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		10321355	211199	0	None	-	1	Guinea pig	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	446	9	2	4	5.1	COc1ccc(C(=O)Nc2ccc(-c3ccc(C(=O)O)cc3C)cc2)cc1CCCN(C)C	10.1021/jm00041a001
		CHEMBL72092	211199	0	None	-	1	Guinea pig	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	446	9	2	4	5.1	COc1ccc(C(=O)Nc2ccc(-c3ccc(C(=O)O)cc3C)cc2)cc1CCCN(C)C	10.1021/jm00041a001
		9950390	73025	0	None	-794	4	Human	5.5	pKi	=	5.5	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	352	3	2	3	3.8	CN1CCC(c2n[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2004.09.079
		CHEMBL184597	73025	0	None	-794	4	Human	5.5	pKi	=	5.5	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	352	3	2	3	3.8	CN1CCC(c2n[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1	10.1016/j.bmcl.2004.09.079
		10811696	109259	0	None	-100	4	Human	6.5	pKi	=	6.5	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	413	6	1	3	4.7	N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)C2	10.1021/jm000090i
		CHEMBL2368612	109259	0	None	-100	4	Human	6.5	pKi	=	6.5	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	413	6	1	3	4.7	N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)C2	10.1021/jm000090i
		CHEMBL3040263	109259	0	None	-100	4	Human	6.5	pKi	=	6.5	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	413	6	1	3	4.7	N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)C2	10.1021/jm000090i
		44330028	215163	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	340	3	2	5	2.3	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccnc1)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL99584	215163	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	340	3	2	5	2.3	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccnc1)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		9891617	214761	0	None	-251	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	486	4	2	6	4.9	Cc1cc(N2CCNCC2)c2cc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)ccc2n1	10.1016/s0960-894x(01)00558-3
		CHEMBL97211	214761	0	None	-251	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	486	4	2	6	4.9	Cc1cc(N2CCNCC2)c2cc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)ccc2n1	10.1016/s0960-894x(01)00558-3
		CHEMBL5094181	222259	22	None	2	5	Human	6.5	pKi	=	6.5	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL		None	None	None		O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1	10.6019/CHEMBL5058647
		9892409	107727	0	None	-63	9	Human	6.5	pKi	=	6.5	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	505	5	1	6	5.3	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1	10.1016/s0960-894x(02)00172-5
		CHEMBL29410	107727	0	None	-63	9	Human	6.5	pKi	=	6.5	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	ChEMBL	505	5	1	6	5.3	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1	10.1016/s0960-894x(02)00172-5
		50898777	63214	0	None	-29512	8	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
		CHEMBL1632158	63214	0	None	-29512	8	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
		9863250	24767	6	None	-1023	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards 5-hydroxytryptamine 1D (human cloned receptor) in CHO cells using [3H]5-HT as radioligand.Binding affinity towards 5-hydroxytryptamine 1D (human cloned receptor) in CHO cells using [3H]5-HT as radioligand.	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
		CHEMBL12624	24767	6	None	-1023	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards 5-hydroxytryptamine 1D (human cloned receptor) in CHO cells using [3H]5-HT as radioligand.Binding affinity towards 5-hydroxytryptamine 1D (human cloned receptor) in CHO cells using [3H]5-HT as radioligand.	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
		281	10283	28	None	-100	5	Human	5.5	pKi	=	5.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
		5312148	10283	28	None	-100	5	Human	5.5	pKi	=	5.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
		CHEMBL12264	10283	28	None	-100	5	Human	5.5	pKi	=	5.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
		CHEMBL5094181	222259	22	None	2	5	Human	6.5	pKi	=	6.5	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL		None	None	None		O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1	10.6019/CHEMBL5058647
		10746433	127861	0	None	-588	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	619	13	3	9	3.0	COCCOC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		CHEMBL357061	127861	0	None	-588	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	619	13	3	9	3.0	COCCOC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		18007533	36254	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	270	4	0	3	3.0	CN(C)CCn1ccc2ccc(C3=CCOCC3)cc21	10.1016/j.bmcl.2003.09.025
		CHEMBL138462	36254	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	270	4	0	3	3.0	CN(C)CCn1ccc2ccc(C3=CCOCC3)cc21	10.1016/j.bmcl.2003.09.025
		117209962	191648	1	None	-12	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4852622	191648	1	None	-12	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		44403105	78883	0	None	-19	5	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	455	5	1	6	3.5	COc1ccc(NC(=O)N2CCN(c3ccc(SC)cc3)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL197796	78883	0	None	-19	5	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	455	5	1	6	3.5	COc1ccc(NC(=O)N2CCN(c3ccc(SC)cc3)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		142601335	193200	0	None	-275	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4876193	193200	0	None	-275	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
		9881603	130074	0	None	134	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	258	2	1	2	3.5	Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCCN1	10.1016/j.bmcl.2004.06.085
		CHEMBL361470	130074	0	None	134	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	258	2	1	2	3.5	Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCCN1	10.1016/j.bmcl.2004.06.085
		10383010	170278	0	None	-12	4	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	346	6	1	2	4.8	CCCN(Cc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL420191	170278	0	None	-12	4	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	346	6	1	2	4.8	CCCN(Cc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		11747350	114109	0	None	-16	10	Human	6.5	pKi	=	6.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	260	5	1	3	2.4	CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C	10.1021/jm010943m
		CHEMBL317535	114109	0	None	-16	10	Human	6.5	pKi	=	6.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	260	5	1	3	2.4	CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C	10.1021/jm010943m
		20255884	72837	0	None	30	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	234	2	2	5	1.6	Cc1cc([N+](=O)[O-])cc(C)c1NC1=NCCN1	10.1016/j.bmcl.2004.06.085
		CHEMBL183704	72837	0	None	30	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	234	2	2	5	1.6	Cc1cc([N+](=O)[O-])cc(C)c1NC1=NCCN1	10.1016/j.bmcl.2004.06.085
		11047115	11792	0	None	-7	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	379	4	2	5	3.5	CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc([N+](=O)[O-])c4)nc23)CC1	10.1021/jm030020m
		CHEMBL105118	11792	0	None	-7	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	379	4	2	5	3.5	CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc([N+](=O)[O-])c4)nc23)CC1	10.1021/jm030020m
		145972374	171453	0	None	-10	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
		CHEMBL4216860	171453	0	None	-10	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
		10403260	211065	0	None	-8	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	312	6	0	3	4.0	CCCN(CCC)C1CCc2ccc3c(c(C=O)cn3C)c2C1	10.1021/jm00012a021
		CHEMBL71299	211065	0	None	-8	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	312	6	0	3	4.0	CCCN(CCC)C1CCc2ccc3c(c(C=O)cn3C)c2C1	10.1021/jm00012a021
		10064361	210943	0	None	-42	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	316	6	1	2	4.1	CCCN(CCC)[C@H]1CCc2cc(F)c3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		CHEMBL70652	210943	0	None	-42	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	316	6	1	2	4.1	CCCN(CCC)[C@H]1CCc2cc(F)c3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		44404394	139593	0	None	-3	7	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	443	4	1	5	3.5	COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL370128	139593	0	None	-3	7	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	443	4	1	5	3.5	COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		19066188	18870	0	None	-19	3	Human	6.5	pKi	=	6.5	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	409	4	1	5	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL1183944	18870	0	None	-19	3	Human	6.5	pKi	=	6.5	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	409	4	1	5	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL325131	18870	0	None	-19	3	Human	6.5	pKi	=	6.5	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	409	4	1	5	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		9837108	211437	3	None	8	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	202	3	1	2	2.4	CC(C)c1ccc(CC2=NCCN2)cc1	10.1021/jm970513p
		CHEMBL73670	211437	3	None	8	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	202	3	1	2	2.4	CC(C)c1ccc(CC2=NCCN2)cc1	10.1021/jm970513p
		11777831	211361	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	268	1	1	1	3.9	c1cc2c3c(ccc2[nH]1)CCC(N1CCCCCC1)C3	10.1021/jm00012a022
		CHEMBL73112	211361	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	268	1	1	1	3.9	c1cc2c3c(ccc2[nH]1)CCC(N1CCCCCC1)C3	10.1021/jm00012a022
		10872581	11701	0	None	-43	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	379	4	2	5	3.5	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc([N+](=O)[O-])cc4)nc23)CC1	10.1021/jm030020m
		CHEMBL104692	11701	0	None	-43	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	379	4	2	5	3.5	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc([N+](=O)[O-])cc4)nc23)CC1	10.1021/jm030020m
		10088426	20527	0	None	-4	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligand	ChEMBL	337	5	1	4	2.8	CCCN[C@@H]1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1	10.1021/jm00008a010
		CHEMBL1195292	20527	0	None	-4	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligand	ChEMBL	337	5	1	4	2.8	CCCN[C@@H]1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1	10.1021/jm00008a010
		CHEMBL554220	20527	0	None	-4	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligand	ChEMBL	337	5	1	4	2.8	CCCN[C@@H]1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1	10.1021/jm00008a010
		44582677	188352	0	None	-1	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL476838	188352	0	None	-1	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
		44403102	78507	0	None	-12	6	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	477	4	1	5	3.8	COc1ccc(NC(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL196598	78507	0	None	-12	6	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	477	4	1	5	3.8	COc1ccc(NC(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		11778645	67090	0	None	-9	4	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	284	5	1	1	4.4	CCCN(CC(C)C)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL1744041	67090	0	None	-9	4	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	284	5	1	1	4.4	CCCN(CC(C)C)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		10378357	110592	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	268	5	1	1	3.9	C=CCN(CCC)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL309121	110592	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	268	5	1	1	3.9	C=CCN(CCC)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		33630	185736	99	None	-24	28	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL47050	185736	99	None	-24	28	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		13702393	161804	2	None	-36	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
		CHEMBL401541	161804	2	None	-36	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
		CHEMBL556983	161804	2	None	-36	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
		10360150	211015	0	None	-5	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	344	7	1	2	4.9	CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C(=O)CC)c3c2C1	10.1021/jm00012a021
		CHEMBL70985	211015	0	None	-5	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	344	7	1	2	4.9	CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C(=O)CC)c3c2C1	10.1021/jm00012a021
		56649649	74632	0	None	-426	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		CHEMBL1910140	74632	0	None	-426	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		19066163	18158	0	None	-28	3	Human	7.4	pKi	=	7.4	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	437	4	1	5	3.4	COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL111302	18158	0	None	-28	3	Human	7.4	pKi	=	7.4	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	437	4	1	5	3.4	COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL1180017	18158	0	None	-28	3	Human	7.4	pKi	=	7.4	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	437	4	1	5	3.4	COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		10721586	126499	0	None	-141	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	559	10	3	7	3.4	CC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		CHEMBL347522	126499	0	None	-141	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	559	10	3	7	3.4	CC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		CHEMBL5094493	222278	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		4376990	199788	5	None	-15	11	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5207529	199788	5	None	-15	11	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5222754	199788	5	None	-15	11	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		11824522	11662	0	None	-52	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	359	3	2	4	3.5	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(C#N)cc4)nc23)CC1	10.1021/jm030020m
		CHEMBL104484	11662	0	None	-52	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	359	3	2	4	3.5	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(C#N)cc4)nc23)CC1	10.1021/jm030020m
		11822996	11831	0	None	-19	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	308	3	2	4	1.7	CN1CCC(c2c[nH]c3ccc(NS(C)(=O)=O)nc23)CC1	10.1021/jm030020m
		CHEMBL105327	11831	0	None	-19	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	308	3	2	4	1.7	CN1CCC(c2c[nH]c3ccc(NS(C)(=O)=O)nc23)CC1	10.1021/jm030020m
		11754707	212936	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in calf caudate homogenates.Binding affinity against 5-hydroxytryptamine 1D receptor in calf caudate homogenates.	ChEMBL	475	9	3	4	3.1	CN(C)CCc1c(C(=O)NCc2ccccc2)[nH]c2ccc(CCN3C(=O)NC(C)(C)C3=O)cc12	10.1021/jm9706325
		CHEMBL86223	212936	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in calf caudate homogenates.Binding affinity against 5-hydroxytryptamine 1D receptor in calf caudate homogenates.	ChEMBL	475	9	3	4	3.1	CN(C)CCc1c(C(=O)NCc2ccccc2)[nH]c2ccc(CCN3C(=O)NC(C)(C)C3=O)cc12	10.1021/jm9706325
		16614092	113018	5	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	219	4	1	2	2.6	CNCCOc1cc(Cl)ccc1Cl	10.1007/s00044-009-9164-1
		CHEMBL2260922	113018	5	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	219	4	1	2	2.6	CNCCOc1cc(Cl)ccc1Cl	10.1007/s00044-009-9164-1
		CHEMBL3138881	113018	5	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	219	4	1	2	2.6	CNCCOc1cc(Cl)ccc1Cl	10.1007/s00044-009-9164-1
		118464425	145087	0	None	-100	9	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		CHEMBL3770981	145087	0	None	-100	9	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		13096730	210145	5	None	-6	4	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	270	5	1	1	4.1	CCCN(CCC)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL65196	210145	5	None	-6	4	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	270	5	1	1	4.1	CCCN(CCC)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		11043914	11552	0	None	-19	3	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	272	2	2	3	2.3	CC(=O)Nc1cc2c(C3CCN(C)CC3)c[nH]c2cn1	10.1021/jm030020m
		CHEMBL104026	11552	0	None	-19	3	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	272	2	2	3	2.3	CC(=O)Nc1cc2c(C3CCN(C)CC3)c[nH]c2cn1	10.1021/jm030020m
		11831220	199337	8	None	8	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	229	1	2	2	2.6	CN1CCC(c2c[nH]c3ccc(N)cc23)CC1	10.1021/jm7011722
		CHEMBL521235	199337	8	None	8	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	229	1	2	2	2.6	CN1CCC(c2c[nH]c3ccc(N)cc23)CC1	10.1021/jm7011722
		10597210	83906	0	None	-3	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	401	3	1	3	4.1	Cc1cc(C(=O)Nc2ccc(C)c(N3CCN(C)CC3)c2)ccc1Br	10.1021/jm970457s
		CHEMBL20771	83906	0	None	-3	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	401	3	1	3	4.1	Cc1cc(C(=O)Nc2ccc(C)c(N3CCN(C)CC3)c2)ccc1Br	10.1021/jm970457s
		10624768	106174	0	None	-15	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	485	9	2	7	5.3	COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1NCCN(C)C	10.1021/jm970457s
		CHEMBL282693	106174	0	None	-15	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	485	9	2	7	5.3	COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1NCCN(C)C	10.1021/jm970457s
		6918601	25295	0	None	-512	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	370	3	1	5	2.7	Cc1ccc(S(=O)(=O)n2cc3c4c(cccc42)[C@H](O)[C@@H](N(C)C)C3)cc1	10.1021/jm010943m
		CHEMBL127411	25295	0	None	-512	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	370	3	1	5	2.7	Cc1ccc(S(=O)(=O)n2cc3c4c(cccc42)[C@H](O)[C@@H](N(C)C)C3)cc1	10.1021/jm010943m
		76322958	113001	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	257	6	1	3	3.5	CNC(C)COc1cccc(Oc2ccccc2)c1	10.1007/s00044-009-9164-1
		CHEMBL2260930	113001	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	257	6	1	3	3.5	CNC(C)COc1cccc(Oc2ccccc2)c1	10.1007/s00044-009-9164-1
		CHEMBL3138809	113001	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	257	6	1	3	3.5	CNC(C)COc1cccc(Oc2ccccc2)c1	10.1007/s00044-009-9164-1
		44402886	78615	0	None	-125	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	497	5	1	5	5.3	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(C(C)=O)cc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL196951	78615	0	None	-125	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	497	5	1	5	5.3	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(C(C)=O)cc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		9871977	172873	0	None	-79	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	539	5	1	6	4.6	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(N4CCCC4=O)nc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL425919	172873	0	None	-79	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	539	5	1	6	4.6	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(N4CCCC4=O)nc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		127036186	144192	0	None	-12	19	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3753318	144192	0	None	-12	19	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		9891002	114185	0	None	-398	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
		CHEMBL318018	114185	0	None	-398	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
		9805456	214525	0	None	-316	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	486	4	2	6	5.0	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN[C@@H](C)C4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
		CHEMBL95823	214525	0	None	-316	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	486	4	2	6	5.0	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN[C@@H](C)C4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
		11168182	10307	25	None	-63	13	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
		264	10307	25	None	-63	13	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
		CHEMBL1181770	10307	25	None	-63	13	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 1D expressed in CHO cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
		10138727	176155	0	None	-501	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL442087	176155	0	None	-501	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		10767427	91169	1	None	-794	4	Human	5.4	pKi	=	5.4	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	491	7	1	5	4.1	CS(=O)(=O)c1cccc(/C=C/C(=O)N[C@H]2CC[C@H](CCN3CCc4cc(C#N)ccc4C3)CC2)c1	10.1021/jm000090i
		CHEMBL2113352	91169	1	None	-794	4	Human	5.4	pKi	=	5.4	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	491	7	1	5	4.1	CS(=O)(=O)c1cccc(/C=C/C(=O)N[C@H]2CC[C@H](CCN3CCc4cc(C#N)ccc4C3)CC2)c1	10.1021/jm000090i
		CHEMBL2219586	91169	1	None	-794	4	Human	5.4	pKi	=	5.4	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	491	7	1	5	4.1	CS(=O)(=O)c1cccc(/C=C/C(=O)N[C@H]2CC[C@H](CCN3CCc4cc(C#N)ccc4C3)CC2)c1	10.1021/jm000090i
		6604789	107824	5	None	-158	10	Human	4.4	pKi	=	4.4	Binding	Binding affinity against 5-Hydroxytryptamine 1D receptorBinding affinity against 5-Hydroxytryptamine 1D receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		CHEMBL294649	107824	5	None	-158	10	Human	4.4	pKi	=	4.4	Binding	Binding affinity against 5-Hydroxytryptamine 1D receptorBinding affinity against 5-Hydroxytryptamine 1D receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		2869	10924	89	None	-2	7	Human	8.4	pKi	=	8.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a020
		60	10924	89	None	-2	7	Human	8.4	pKi	=	8.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a020
		60857	10924	89	None	-2	7	Human	8.4	pKi	=	8.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a020
		CHEMBL1185	10924	89	None	-2	7	Human	8.4	pKi	=	8.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a020
		DB00315	10924	89	None	-2	7	Human	8.4	pKi	=	8.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a020
		44342823	120586	0	None	2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	472	4	2	2	5.6	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL332484	120586	0	None	2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	472	4	2	2	5.6	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)CC3)cc12	10.1016/s0960-894x(03)00779-0
		107	6929	121	None	-8	31	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm950498t
		1833	6929	121	None	-8	31	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm950498t
		CHEMBL8165	6929	121	None	-8	31	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm950498t
		1043	8363	14	None	-23	29	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation countingDisplacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation counting	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2011.09.046
		149	8363	14	None	-23	29	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation countingDisplacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation counting	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2011.09.046
		8223	8363	14	None	-23	29	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation countingDisplacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation counting	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2011.09.046
		CHEMBL442	8363	14	None	-23	29	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation countingDisplacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation counting	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2011.09.046
		DB00696	8363	14	None	-23	29	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation countingDisplacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation counting	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmcl.2011.09.046
		2393	10107	82	None	1	5	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9805945
		5078	10107	82	None	1	5	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9805945
		51	10107	82	None	1	5	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9805945
		CHEMBL905	10107	82	None	1	5	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9805945
		DB00953	10107	82	None	1	5	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm9805945
		10448470	211043	0	None	-14	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	316	6	1	2	4.1	CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		CHEMBL71176	211043	0	None	-14	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	316	6	1	2	4.1	CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		1251	8473	30	None	1	3	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	10.1021/jm9805945
		7191	8473	30	None	1	3	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	10.1021/jm9805945
		77992	8473	30	None	1	3	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	10.1021/jm9805945
		CHEMBL1279	8473	30	None	1	3	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	10.1021/jm9805945
		DB00998	8473	30	None	1	3	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	10.1021/jm9805945
		2543	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805945
		5358	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805945
		54	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805945
		CHEMBL128	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805945
		DB00669	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9805945
		9817810	24144	1	None	-1	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	300	4	1	4	2.4	NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		CHEMBL125745	24144	1	None	-1	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	300	4	1	4	2.4	NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		44383729	66701	0	None	23	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	294	4	1	2	4.3	C1=CCN(CCc2c[nH]c3ccc(-c4cccs4)cc23)C1	10.1016/s0960-894x(00)00133-5
		CHEMBL173162	66701	0	None	23	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	294	4	1	2	4.3	C1=CCN(CCc2c[nH]c3ccc(-c4cccs4)cc23)C1	10.1016/s0960-894x(00)00133-5
		11723305	176044	0	None	-9	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	316	6	1	2	4.1	CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		CHEMBL441256	176044	0	None	-9	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	316	6	1	2	4.1	CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C=O)c3c2C1	10.1021/jm00012a021
		9845148	176021	38	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	422	6	2	5	2.0	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(c2ccc(C(N)=O)cc2)CC1	10.1016/j.bmcl.2003.09.025
		CHEMBL441095	176021	38	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	422	6	2	5	2.0	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(c2ccc(C(N)=O)cc2)CC1	10.1016/j.bmcl.2003.09.025
		11384146	208512	0	None	-11	9	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cellsInhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12	10.1021/jm049243i
		CHEMBL606556	208512	0	None	-11	9	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cellsInhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12	10.1021/jm049243i
		5	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00018a020
		5202	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00018a020
		CHEMBL39	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00018a020
		DB08839	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00018a020
		10802304	115313	1	None	-4	3	Human	8.3	pKi	=	8.3	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	274	9	2	2	4.0	CCCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		CHEMBL320079	115313	1	None	-4	3	Human	8.3	pKi	=	8.3	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	274	9	2	2	4.0	CCCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		13096730	210145	5	None	-6	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	270	5	1	1	4.1	CCCN(CCC)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a021
		CHEMBL65196	210145	5	None	-6	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	270	5	1	1	4.1	CCCN(CCC)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a021
		2393	10107	82	None	1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00018a020
		5078	10107	82	None	1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00018a020
		51	10107	82	None	1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00018a020
		CHEMBL905	10107	82	None	1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00018a020
		DB00953	10107	82	None	1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1021/jm00018a020
		44460826	177207	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	439	5	1	5	4.4	NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2nsc3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL444843	177207	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	439	5	1	5	4.4	NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2nsc3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		44461248	212138	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	407	5	2	3	3.9	NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2c[nH]c3cc(F)ccc23)C1	10.1016/j.bmcl.2004.03.003
		CHEMBL79725	212138	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	407	5	2	3	3.9	NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2c[nH]c3cc(F)ccc23)C1	10.1016/j.bmcl.2004.03.003
		11808793	11301	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	301	3	3	3	2.5	CCNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		CHEMBL102292	11301	0	None	-10	2	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	301	3	3	3	2.5	CCNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		CHEMBL5093342	222343	0	None	-4	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5095971	222343	0	None	-4	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		16117151	66861	0	None	-407	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT1D receptorBinding affinity to 5-HT1D receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		CHEMBL1642882	66861	0	None	-407	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT1D receptorBinding affinity to 5-HT1D receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		CHEMBL1739102	66861	0	None	-407	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT1D receptorBinding affinity to 5-HT1D receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
		146025727	178464	0	None	-151	27	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4466483	178464	0	None	-151	27	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		44581972	182379	0	None	-13	10	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from 5HT1D receptor expressed in CHO cells	ChEMBL	499	6	2	6	4.3	O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		CHEMBL458001	182379	0	None	-13	10	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from 5HT1D receptor expressed in CHO cells	ChEMBL	499	6	2	6	4.3	O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		CHEMBL4778870	220826	8	None	-1	5	Human	6.4	pKi	=	6.4	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL		None	None	None		CC1CCN(c2ccnc(NCc3cn(C)cn3)n2)CC1	10.6019/CHEMBL4800732
		72550642	120855	0	None	-47	8	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT1D (unknown origin)Binding affinity to 5-HT1D (unknown origin)	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
		CHEMBL3326982	120855	0	None	-47	8	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT1D (unknown origin)Binding affinity to 5-HT1D (unknown origin)	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
		10065239	211068	0	None	-14	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	330	6	0	3	4.1	CCCN(CCC)C1CCc2cc(F)c3c(c(C=O)cn3C)c2C1	10.1021/jm00012a021
		CHEMBL71319	211068	0	None	-14	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	330	6	0	3	4.1	CCCN(CCC)C1CCc2cc(F)c3c(c(C=O)cn3C)c2C1	10.1021/jm00012a021
		10379784	211161	1	None	-34	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	295	5	1	2	4.0	CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C#N)c3c2C1	10.1021/jm00012a021
		CHEMBL71804	211161	1	None	-34	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	295	5	1	2	4.0	CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C#N)c3c2C1	10.1021/jm00012a021
		10828231	16126	2	None	-2	3	Human	7.4	pKi	=	7.4	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	302	10	2	2	4.7	CC(C)CCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		CHEMBL111283	16126	2	None	-2	3	Human	7.4	pKi	=	7.4	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	302	10	2	2	4.7	CC(C)CCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		10567450	16127	1	None	-1	3	Human	7.4	pKi	=	7.4	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	316	12	2	2	5.2	CCCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		CHEMBL111284	16127	1	None	-1	3	Human	7.4	pKi	=	7.4	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	316	12	2	2	5.2	CCCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		10782681	116244	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	330	12	1	2	5.4	CCCCCCCCCOc1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm950498t
		CHEMBL322054	116244	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	330	12	1	2	5.4	CCCCCCCCCOc1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm950498t
		11759467	11941	0	None	-50	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	335	3	2	4	3.0	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1	10.1021/jm030020m
		CHEMBL105958	11941	0	None	-50	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	335	3	2	4	3.0	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1	10.1021/jm030020m
		10220230	114199	2	None	-4	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	230	1	2	3	2.0	CN1CCC(c2c[nH]c3ccc(N)nc23)CC1	10.1021/jm030020m
		CHEMBL318105	114199	2	None	-4	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	230	1	2	3	2.0	CN1CCC(c2c[nH]c3ccc(N)nc23)CC1	10.1021/jm030020m
		19066235	18157	0	None	-1047	3	Human	4.4	pKi	=	4.4	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	437	6	1	6	2.5	COc1ccc(NCC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL110601	18157	0	None	-1047	3	Human	4.4	pKi	=	4.4	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	437	6	1	6	2.5	COc1ccc(NCC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL1180011	18157	0	None	-1047	3	Human	4.4	pKi	=	4.4	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	437	6	1	6	2.5	COc1ccc(NCC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		10356544	210770	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	284	5	1	1	4.5	CCCN(CCC)C1CCc2ccc3[nH]cc(C)c3c2C1	10.1021/jm00012a021
		CHEMBL69562	210770	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	284	5	1	1	4.5	CCCN(CCC)C1CCc2ccc3[nH]cc(C)c3c2C1	10.1021/jm00012a021
		151	9194	44	None	-151	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1021/jm030020m
		20	9194	44	None	-151	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1021/jm030020m
		5311258	9194	44	None	-151	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1021/jm030020m
		CHEMBL101690	9194	44	None	-151	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1021/jm030020m
		151	9194	44	None	-151	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1016/j.bmcl.2004.09.079
		20	9194	44	None	-151	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1016/j.bmcl.2004.09.079
		5311258	9194	44	None	-151	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1016/j.bmcl.2004.09.079
		CHEMBL101690	9194	44	None	-151	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity for human 5-hydroxytryptamine 1D receptorIn vitro binding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	10.1016/j.bmcl.2004.09.079
		134611895	9447	4	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	515	8	3	7	4.5	NCCCNC(=O)c1ccc(s1)c1cc(cc(c1)n1nnc(c1)c1ccc(cc1)C(F)(F)F)C(=O)O	10.1021/acs.jmedchem.0c00745
		9998	9447	4	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	515	8	3	7	4.5	NCCCNC(=O)c1ccc(s1)c1cc(cc(c1)n1nnc(c1)c1ccc(cc1)C(F)(F)F)C(=O)O	10.1021/acs.jmedchem.0c00745
		CHEMBL4212721	9447	4	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	515	8	3	7	4.5	NCCCNC(=O)c1ccc(s1)c1cc(cc(c1)n1nnc(c1)c1ccc(cc1)C(F)(F)F)C(=O)O	10.1021/acs.jmedchem.0c00745
		10490160	111063	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	238	2	1	2	2.0	Brc1ccc(CC2=NCCN2)cc1	10.1021/jm970513p
		CHEMBL309976	111063	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	238	2	1	2	2.0	Brc1ccc(CC2=NCCN2)cc1	10.1021/jm970513p
		56935645	74692	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation countingDisplacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation counting	ChEMBL	553	5	1	6	5.1	COc1ccc(NC(=O)c2ccc3c(c2)N(C)C(=O)CN3c2ccc(Cl)c(Cl)c2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2011.09.046
		CHEMBL1910792	74692	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation countingDisplacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation counting	ChEMBL	553	5	1	6	5.1	COc1ccc(NC(=O)c2ccc3c(c2)N(C)C(=O)CN3c2ccc(Cl)c(Cl)c2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2011.09.046
		10468376	108863	1	None	-97	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	270	5	1	1	4.1	CCCN(CCC)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a021
		CHEMBL302171	108863	1	None	-97	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	270	5	1	1	4.1	CCCN(CCC)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a021
		10065919	109867	0	None	-8	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	341	7	2	3	2.8	CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1	10.1021/jm00012a021
		CHEMBL307521	109867	0	None	-8	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	341	7	2	3	2.8	CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1	10.1021/jm00012a021
		11035452	11776	0	None	-36	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	348	3	2	3	3.9	Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		CHEMBL105025	11776	0	None	-36	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	348	3	2	3	3.9	Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		10468376	108863	1	None	-97	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	270	5	1	1	4.1	CCCN(CCC)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL302171	108863	1	None	-97	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	270	5	1	1	4.1	CCCN(CCC)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		145980875	173486	0	None	-33	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	443	7	1	2	6.2	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4282702	173486	0	None	-33	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	443	7	1	2	6.2	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		16006606	164440	3	None	-70	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	191	1	2	4	1.3	COc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		CHEMBL408152	164440	3	None	-70	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	191	1	2	4	1.3	COc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		15870567	193752	0	None	36	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	242	4	1	1	3.4	CCc1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1016/s0960-894x(00)00322-x
		CHEMBL49048	193752	0	None	36	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	242	4	1	1	3.4	CCc1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1016/s0960-894x(00)00322-x
		11260311	78951	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Inhibition constant against 5-hydroxytryptamine 1D receptorInhibition constant against 5-hydroxytryptamine 1D receptor	ChEMBL	487	5	1	5	5.0	C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CCC1OCCc2c1sc(C(N)=O)c2Cl	10.1021/jm058225d
		CHEMBL197982	78951	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Inhibition constant against 5-hydroxytryptamine 1D receptorInhibition constant against 5-hydroxytryptamine 1D receptor	ChEMBL	487	5	1	5	5.0	C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CCC1OCCc2c1sc(C(N)=O)c2Cl	10.1021/jm058225d
		11800278	45965	0	None	-17	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	527	10	3	8	2.4	CCOC(=O)C1CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(=O)NC)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		CHEMBL146983	45965	0	None	-17	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	527	10	3	8	2.4	CCOC(=O)C1CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(=O)NC)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		127035062	143229	0	None	-15	19	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735756	143229	0	None	-15	19	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		10793261	127831	0	None	-3235	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	575	10	3	8	3.0	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		CHEMBL356829	127831	0	None	-3235	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	575	10	3	8	3.0	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		135458394	104467	5	None	-72	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	243	0	2	3	2.9	CNC1=Nc2ccc(Cl)c(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
		CHEMBL271298	104467	5	None	-72	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	243	0	2	3	2.9	CNC1=Nc2ccc(Cl)c(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
		44581974	182483	0	None	-8	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from 5HT1D receptor expressed in CHO cells	ChEMBL	513	6	2	6	4.6	Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		CHEMBL458220	182483	0	None	-8	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from 5HT1D receptor expressed in CHO cells	ChEMBL	513	6	2	6	4.6	Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		10793504	48514	0	None	-588	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	588	10	3	8	3.2	CCOC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc3c(c2)OCO3)CC1	10.1021/jm980506g
		CHEMBL149263	48514	0	None	-588	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	588	10	3	8	3.2	CCOC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc3c(c2)OCO3)CC1	10.1021/jm980506g
		64622	103629	6	None	-1148	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT as radioligand	ChEMBL	425	8	1	4	3.9	COc1ccccc1N1CCN(CCCCNC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)CC1	10.1021/jm00112a043
		CHEMBL26533	103629	6	None	-1148	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT as radioligand	ChEMBL	425	8	1	4	3.9	COc1ccccc1N1CCN(CCCCNC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)CC1	10.1021/jm00112a043
		122483281	144886	0	None	-93	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3763779	144886	0	None	-93	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL3765873	144886	0	None	-93	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT1D receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
		CHEMBL4455357	220718	26	None	-	1	Human	5.3	pKi	=	5.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000315b HTR1DSelectivity interaction (GPCR panel (PDSP screen)) EUB0000315b HTR1D	ChEMBL		None	None	None		Cn1nc(C(F)(F)F)cc1-c1cnc(N2CCc3cc(S(=O)(=O)Nc4c(F)cc(Cl)cc4F)cc(N4CCCC4=O)c32)nc1	10.6019/CHEMBL5212743
		10721049	50496	0	None	-602	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	533	9	4	7	2.8	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(O)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		CHEMBL151045	50496	0	None	-602	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	533	9	4	7	2.8	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(O)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		10891048	11583	0	None	-2	4	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	273	2	2	4	1.7	CC(=O)Nc1ncc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		CHEMBL104158	11583	0	None	-2	4	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	273	2	2	4	1.7	CC(=O)Nc1ncc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		10251722	18149	0	None	-20	3	Human	7.3	pKi	=	7.3	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	423	4	1	5	3.1	COc1ccc(NC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL105970	18149	0	None	-20	3	Human	7.3	pKi	=	7.3	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	423	4	1	5	3.1	COc1ccc(NC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL1179958	18149	0	None	-20	3	Human	7.3	pKi	=	7.3	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	423	4	1	5	3.1	COc1ccc(NC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		10603688	127924	0	None	-1000	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	603	11	3	8	3.7	CCNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		CHEMBL357681	127924	0	None	-1000	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	603	11	3	8	3.7	CCNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		181743	185351	5	None	-24	22	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]GR127543 from human 5HT1D receptorDisplacement of [3H]GR127543 from human 5HT1D receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		CHEMBL467094	185351	5	None	-24	22	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]GR127543 from human 5HT1D receptorDisplacement of [3H]GR127543 from human 5HT1D receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		10926112	179410	0	None	-85	4	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	348	3	2	3	3.9	Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1	10.1021/jm030020m
		CHEMBL449406	179410	0	None	-85	4	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	348	3	2	3	3.9	Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1	10.1021/jm030020m
		10698630	51207	0	None	-2290	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	589	11	3	8	3.4	CCOC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		CHEMBL151878	51207	0	None	-2290	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	589	11	3	8	3.4	CCOC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		10456474	21311	0	None	6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	451	9	2	6	3.1	NCCc1c[nH]c2ccc(OCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		CHEMBL120272	21311	0	None	6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta	ChEMBL	451	9	2	6	3.1	NCCc1c[nH]c2ccc(OCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12	10.1021/jm00018a020
		10003971	69807	0	None	-8	4	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	451	9	1	4	4.5	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL1788198	69807	0	None	-8	4	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	451	9	1	4	4.5	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		10673329	106108	0	None	-10	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	512	8	0	7	5.2	COc1cc2c(cc1OCCN(C)C)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2	10.1021/jm970457s
		CHEMBL282229	106108	0	None	-10	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	512	8	0	7	5.2	COc1cc2c(cc1OCCN(C)C)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2	10.1021/jm970457s
		11259254	131947	0	None	12	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	440	7	0	6	4.3	Cc1ccc2c(OCCN3CCN(Cc4ccc(Cl)c([N+](=O)[O-])c4)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL364495	131947	0	None	12	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	440	7	0	6	4.3	Cc1ccc2c(OCCN3CCN(Cc4ccc(Cl)c([N+](=O)[O-])c4)CC3)cccc2n1	10.1021/jm049039v
		24865541	194456	0	None	251	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	418	7	1	5	3.7	CC(=O)Nc1ccccc1CN1CCN(CCOc2cccc3nc(C)ccc23)CC1	10.1021/jm8001444
		CHEMBL495161	194456	0	None	251	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	418	7	1	5	3.7	CC(=O)Nc1ccccc1CN1CCN(CCOc2cccc3nc(C)ccc23)CC1	10.1021/jm8001444
		9891594	111658	0	None	1	3	Guinea pig	8.3	pKi	=	8.3	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	486	6	1	5	4.4	COc1ccc(NC(=O)c2ccc(-c3ccc(C(=O)N(C)C)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm00041a001
		CHEMBL311150	111658	0	None	1	3	Guinea pig	8.3	pKi	=	8.3	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	486	6	1	5	4.4	COc1ccc(NC(=O)c2ccc(-c3ccc(C(=O)N(C)C)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm00041a001
		9865842	211342	0	None	251	2	Guinea pig	8.3	pKi	=	8.3	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	402	5	1	5	3.8	COc1ccc(NC(=O)c2ccc(-c3ccncc3)cc2)cc1N1CCN(C)CC1	10.1021/jm00041a001
		CHEMBL72981	211342	0	None	251	2	Guinea pig	8.3	pKi	=	8.3	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	402	5	1	5	3.8	COc1ccc(NC(=O)c2ccc(-c3ccncc3)cc2)cc1N1CCN(C)CC1	10.1021/jm00041a001
		5	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(98)00222-4
		5202	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(98)00222-4
		CHEMBL39	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(98)00222-4
		DB08839	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(98)00222-4
		10432512	109166	0	None	-6	4	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	424	9	1	3	5.7	CCCN(CCCOc1cccc(Cl)c1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL303921	109166	0	None	-6	4	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	424	9	1	3	5.7	CCCN(CCCOc1cccc(Cl)c1)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		10912152	108230	0	None	89	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	256	4	1	1	3.9	CC(C)c1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1016/s0960-894x(00)00322-x
		CHEMBL297660	108230	0	None	89	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	256	4	1	1	3.9	CC(C)c1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1016/s0960-894x(00)00322-x
		CHEMBL5094234	222352	0	None	-2	8	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		CHEMBL5096019	222352	0	None	-2	8	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		10070281	212340	0	None	28	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	412	5	1	3	4.7	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2cccc3ccccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL81191	212340	0	None	28	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	412	5	1	3	4.7	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2cccc3ccccc23)CC1	10.1016/j.bmcl.2004.03.003
		107	6929	121	None	-8	31	Human	8.3	pKi	=	8.3	Binding	Selectivity towards 5-hydroxytryptamine 1D receptor beta to that of 5-hydroxytryptamine 1D receptor alphaSelectivity towards 5-hydroxytryptamine 1D receptor beta to that of 5-hydroxytryptamine 1D receptor alpha	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm950498t
		1833	6929	121	None	-8	31	Human	8.3	pKi	=	8.3	Binding	Selectivity towards 5-hydroxytryptamine 1D receptor beta to that of 5-hydroxytryptamine 1D receptor alphaSelectivity towards 5-hydroxytryptamine 1D receptor beta to that of 5-hydroxytryptamine 1D receptor alpha	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm950498t
		CHEMBL8165	6929	121	None	-8	31	Human	8.3	pKi	=	8.3	Binding	Selectivity towards 5-hydroxytryptamine 1D receptor beta to that of 5-hydroxytryptamine 1D receptor alphaSelectivity towards 5-hydroxytryptamine 1D receptor beta to that of 5-hydroxytryptamine 1D receptor alpha	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm950498t
		2543	10479	68	None	-1	32	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(00)00322-x
		5358	10479	68	None	-1	32	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(00)00322-x
		54	10479	68	None	-1	32	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(00)00322-x
		CHEMBL128	10479	68	None	-1	32	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(00)00322-x
		DB00669	10479	68	None	-1	32	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(00)00322-x
		5	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HTBinding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HT	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00044a001
		5202	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HTBinding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HT	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00044a001
		CHEMBL39	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HTBinding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HT	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00044a001
		DB08839	6927	72	None	-6	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HTBinding affinity was measured on 5-hydroxytryptamine 1D receptor alpha in COS cells transfected with human 5-HT1D alpha gene labeled with [3H]5-HT	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00044a001
		44342507	116966	0	None	6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	488	4	2	2	6.1	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/C45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL323705	116966	0	None	6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	488	4	2	2	6.1	CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/C45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)CC3)cc12	10.1016/s0960-894x(03)00779-0
		18007572	36757	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	288	4	0	3	3.8	CN(C)CCn1ccc2ccc(C3CCSCC3)cc21	10.1016/j.bmcl.2003.09.025
		CHEMBL138873	36757	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	288	4	0	3	3.8	CN(C)CCn1ccc2ccc(C3CCSCC3)cc21	10.1016/j.bmcl.2003.09.025
		2543	10479	68	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9604890
		5358	10479	68	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9604890
		54	10479	68	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9604890
		CHEMBL128	10479	68	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9604890
		DB00669	10479	68	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm9604890
		4656	129738	7	None	39	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	355	1	2	1	2.8	Clc1cc(I)cc(Cl)c1N=C1NCCN1	10.1016/j.bmcl.2004.06.085
		CHEMBL360803	129738	7	None	39	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	355	1	2	1	2.8	Clc1cc(I)cc(Cl)c1N=C1NCCN1	10.1016/j.bmcl.2004.06.085
		44402882	139787	0	None	-19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	496	3	1	4	5.5	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(C(F)(F)F)c1Cl)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL370214	139787	0	None	-19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	496	3	1	4	5.5	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(C(F)(F)F)c1Cl)CC2	10.1016/j.bmcl.2005.07.085
		9842861	33084	0	None	-114	4	Human	5.3	pKi	=	5.3	Binding	Affinity at 5-hydroxytryptamine 1D receptor (For sumatriptan = Ki (nM)-12+/-1.9)Affinity at 5-hydroxytryptamine 1D receptor (For sumatriptan = Ki (nM)-12+/-1.9)	ChEMBL	380	6	0	5	4.3	COc1ccccc1N1CCN(CCC(=O)c2csc3ccccc23)CC1	10.1021/jm001059j
		CHEMBL135878	33084	0	None	-114	4	Human	5.3	pKi	=	5.3	Binding	Affinity at 5-hydroxytryptamine 1D receptor (For sumatriptan = Ki (nM)-12+/-1.9)Affinity at 5-hydroxytryptamine 1D receptor (For sumatriptan = Ki (nM)-12+/-1.9)	ChEMBL	380	6	0	5	4.3	COc1ccccc1N1CCN(CCC(=O)c2csc3ccccc23)CC1	10.1021/jm001059j
		44402893	76584	0	None	-63	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	470	4	1	5	4.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3cc(C)ncc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL193616	76584	0	None	-63	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	470	4	1	5	4.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3cc(C)ncc3C)cc1)CC2	10.1016/j.bmcl.2005.07.085
		130	10273	47	None	-120	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm970457s
		3378093	10273	47	None	-120	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm970457s
		CHEMBL281350	10273	47	None	-120	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.1021/jm970457s
		10573876	17234	0	None	-251	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm991151j
		CHEMBL116448	17234	0	None	-251	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm991151j
		10597140	69819	0	None	-31	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL1788231	69819	0	None	-31	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		44593711	191102	0	None	-5	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	445	6	1	5	4.6	Cc1ccc2c(OCC(C)N3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL484216	191102	0	None	-5	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	445	6	1	5	4.6	Cc1ccc2c(OCC(C)N3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		21309471	214428	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	407	3	2	4	4.2	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1c(Cl)cccc1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL95250	214428	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	407	3	2	4	4.2	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1c(Cl)cccc1Cl)[C@@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		44461168	176254	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	434	5	1	5	3.6	Cn1nc(C2=CCN(CCC3OCCc4cc(C(N)=O)ccc43)CC2)c2ccc(F)cc21	10.1016/j.bmcl.2004.03.003
		CHEMBL442974	176254	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	434	5	1	5	3.6	Cn1nc(C2=CCN(CCC3OCCc4cc(C(N)=O)ccc43)CC2)c2ccc(F)cc21	10.1016/j.bmcl.2004.03.003
		9927441	214173	0	None	-151	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1021/jm010943m
		CHEMBL93868	214173	0	None	-151	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1021/jm010943m
		10651027	127841	0	None	-13	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	588	11	3	7	3.7	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(CN(C)C)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		CHEMBL356923	127841	0	None	-13	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	588	11	3	7	3.7	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(CN(C)C)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		11725335	109047	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	348	6	1	3	3.6	CCCN(CCC)C1CCc2ccc3[nH]cc(S(C)(=O)=O)c3c2C1	10.1021/jm00012a021
		CHEMBL303269	109047	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	348	6	1	3	3.6	CCCN(CCC)C1CCc2ccc3[nH]cc(S(C)(=O)=O)c3c2C1	10.1021/jm00012a021
		56963799	81670	0	None	-13182	10	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human recombinant 5HT1D receptorBinding affinity to human recombinant 5HT1D receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
		CHEMBL2031737	81670	0	None	-13182	10	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human recombinant 5HT1D receptorBinding affinity to human recombinant 5HT1D receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
		10904295	11481	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	352	3	2	3	3.8	CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)cc23)CC1	10.1021/jm030020m
		CHEMBL103503	11481	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	352	3	2	3	3.8	CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)cc23)CC1	10.1021/jm030020m
		145975226	170712	0	None	1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
		CHEMBL4207529	170712	0	None	1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
		145978113	170616	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	207	2	1	3	1.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4206418	170616	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	207	2	1	3	1.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		9997422	211055	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	341	7	2	3	2.8	CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1	10.1021/jm00012a021
		CHEMBL71247	211055	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	341	7	2	3	2.8	CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1	10.1021/jm00012a021
		10247448	211168	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	352	6	1	1	5.3	CCCN(CCC)C1CCc2ccc3[nH]cc(CC(F)(F)F)c3c2C1	10.1021/jm00012a021
		CHEMBL71899	211168	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	352	6	1	1	5.3	CCCN(CCC)C1CCc2ccc3[nH]cc(CC(F)(F)F)c3c2C1	10.1021/jm00012a021
		12406830	72046	2	None	26	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	267	1	2	1	2.2	Cc1cc(Br)cc(C)c1N=C1NCCN1	10.1016/j.bmcl.2004.06.085
		CHEMBL182837	72046	2	None	26	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	267	1	2	1	2.2	Cc1cc(Br)cc(C)c1N=C1NCCN1	10.1016/j.bmcl.2004.06.085
		10068933	110578	0	None	-53	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	389	8	1	4	4.5	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1CCCN(C)C	10.1021/jm9702948
		CHEMBL309021	110578	0	None	-53	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	389	8	1	4	4.5	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1CCCN(C)C	10.1021/jm9702948
		76322956	112981	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	233	4	1	2	3.0	CNC(C)COc1cc(Cl)ccc1Cl	10.1007/s00044-009-9164-1
		CHEMBL2260927	112981	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	233	4	1	2	3.0	CNC(C)COc1cc(Cl)ccc1Cl	10.1007/s00044-009-9164-1
		CHEMBL3138744	112981	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	233	4	1	2	3.0	CNC(C)COc1cc(Cl)ccc1Cl	10.1007/s00044-009-9164-1
		76312090	113026	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	364	5	0	3	4.4	CN1CCN([C@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1	10.1007/s00044-009-9164-1
		CHEMBL2260934	113026	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	364	5	0	3	4.4	CN1CCN([C@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1	10.1007/s00044-009-9164-1
		CHEMBL3138934	113026	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	364	5	0	3	4.4	CN1CCN([C@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1	10.1007/s00044-009-9164-1
		10710400	15958	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	314	8	2	2	4.8	NCCc1c[nH]c2ccc(OCCCCC3CCCCC3)cc12	10.1021/jm950498t
		CHEMBL110318	15958	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	314	8	2	2	4.8	NCCc1c[nH]c2ccc(OCCCCC3CCCCC3)cc12	10.1021/jm950498t
		9802187	212627	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL83617	212627	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		44431531	94800	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	447	5	1	4	4.3	C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CCC1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		CHEMBL234447	94800	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	447	5	1	4	4.3	C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CCC1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		9802187	212627	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Inhibition constant against 5-HT 1D receptorInhibition constant against 5-HT 1D receptor	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1	10.1021/jm058225d
		CHEMBL83617	212627	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Inhibition constant against 5-HT 1D receptorInhibition constant against 5-HT 1D receptor	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1	10.1021/jm058225d
		10643939	20883	0	None	-35	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	387	7	1	4	4.6	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C/CN(C)C	10.1021/jm9702948
		CHEMBL119800	20883	0	None	-35	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	387	7	1	4	4.6	COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C/CN(C)C	10.1021/jm9702948
		10698880	127646	0	None	-912	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	603	11	3	8	3.7	CCOC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(=O)NC)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		CHEMBL355910	127646	0	None	-912	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	603	11	3	8	3.7	CCOC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(=O)NC)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		49783415	24450	0	None	-7585	12	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5-HT1D receptorBinding affinity to human 5-HT1D receptor	ChEMBL	320	7	1	5	2.9	CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1	10.1021/jm100668r
		CHEMBL1258452	24450	0	None	-7585	12	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5-HT1D receptorBinding affinity to human 5-HT1D receptor	ChEMBL	320	7	1	5	2.9	CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1	10.1021/jm100668r
		44461586	212498	0	None	-8	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	437	5	2	3	4.3	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3c(F)c(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL82523	212498	0	None	-8	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	437	5	2	3	4.3	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3c(F)c(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		44358407	37424	4	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	314	4	0	2	5.0	CN(C)CCn1ccc2ccc(-c3ccc4ccccc4c3)cc21	10.1016/j.bmcl.2003.09.025
		CHEMBL139438	37424	4	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	314	4	0	2	5.0	CN(C)CCn1ccc2ccc(-c3ccc4ccccc4c3)cc21	10.1016/j.bmcl.2003.09.025
		10398118	108898	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	207	3	1	1	2.7	CCCNC1CCc2cc(F)ccc2C1	10.1021/jm00012a021
		CHEMBL302373	108898	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	207	3	1	1	2.7	CCCNC1CCc2cc(F)ccc2C1	10.1021/jm00012a021
		10651706	128292	0	None	-97	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	637	11	3	8	4.5	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(C(=O)Oc3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		CHEMBL358406	128292	0	None	-97	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	637	11	3	8	4.5	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(C(=O)Oc3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		71062646	156322	0	None	-977	13	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
		CHEMBL3946661	156322	0	None	-977	13	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
		76315631	112990	0	None	4	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	233	4	1	2	3.0	CNC(C)COc1cccc(Cl)c1Cl	10.1007/s00044-009-9164-1
		CHEMBL2260925	112990	0	None	4	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	233	4	1	2	3.0	CNC(C)COc1cccc(Cl)c1Cl	10.1007/s00044-009-9164-1
		CHEMBL3138773	112990	0	None	4	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	233	4	1	2	3.0	CNC(C)COc1cccc(Cl)c1Cl	10.1007/s00044-009-9164-1
		9845148	176021	38	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human 5-HT1D expressed in CHO cells assessed as inhibition constant incubated for 1 hr by Cheng-Prusoff equation analysisBinding affinity to human 5-HT1D expressed in CHO cells assessed as inhibition constant incubated for 1 hr by Cheng-Prusoff equation analysis	ChEMBL	422	6	2	5	2.0	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(c2ccc(C(N)=O)cc2)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL441095	176021	38	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human 5-HT1D expressed in CHO cells assessed as inhibition constant incubated for 1 hr by Cheng-Prusoff equation analysisBinding affinity to human 5-HT1D expressed in CHO cells assessed as inhibition constant incubated for 1 hr by Cheng-Prusoff equation analysis	ChEMBL	422	6	2	5	2.0	CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(c2ccc(C(N)=O)cc2)CC1	10.1021/acs.jmedchem.2c00633
		1043	8363	14	None	-23	29	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation countingDisplacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation counting	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmc.2011.08.033
		149	8363	14	None	-23	29	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation countingDisplacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation counting	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmc.2011.08.033
		8223	8363	14	None	-23	29	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation countingDisplacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation counting	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmc.2011.08.033
		CHEMBL442	8363	14	None	-23	29	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation countingDisplacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation counting	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmc.2011.08.033
		DB00696	8363	14	None	-23	29	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation countingDisplacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation counting	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1016/j.bmc.2011.08.033
		44376263	63007	0	None	13	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	448	6	2	3	4.9	O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccc(Cl)cc1	10.1016/j.bmcl.2003.11.023
		CHEMBL162724	63007	0	None	13	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	448	6	2	3	4.9	O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccc(Cl)cc1	10.1016/j.bmcl.2003.11.023
		1342	6824	49	None	-3	19	Human	8.2	pKi	=	8.2	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1016/s0960-894x(98)00222-4
		3	6824	49	None	-3	19	Human	8.2	pKi	=	8.2	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1016/s0960-894x(98)00222-4
		CHEMBL277120	6824	49	None	-3	19	Human	8.2	pKi	=	8.2	Binding	Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1016/s0960-894x(98)00222-4
		44376395	59368	0	None	9	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	460	7	2	4	4.8	COc1ccc(C(=S)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		CHEMBL159278	59368	0	None	9	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	460	7	2	4	4.8	COc1ccc(C(=S)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		10753714	46423	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	258	5	2	1	4.0	CCCNCCc1c[nH]c2ccc(C(C)(C)C)cc12	10.1021/jm9805945
		CHEMBL147454	46423	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	258	5	2	1	4.0	CCCNCCc1c[nH]c2ccc(C(C)(C)C)cc12	10.1021/jm9805945
		1342	6824	49	None	-3	19	Human	8.2	pKi	=	8.2	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm9703552
		3	6824	49	None	-3	19	Human	8.2	pKi	=	8.2	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm9703552
		CHEMBL277120	6824	49	None	-3	19	Human	8.2	pKi	=	8.2	Binding	Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsReceptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm9703552
		10127149	181693	0	None	5	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	426	7	0	4	6.1	Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccoc5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL456460	181693	0	None	5	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	426	7	0	4	6.1	Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccoc5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		44443098	100704	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	522	8	0	6	4.7	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(Cc4ccccc4)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		CHEMBL248231	100704	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells	ChEMBL	522	8	0	6	4.7	Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(Cc4ccccc4)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2007.06.078
		44588745	191761	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	417	5	1	5	4.0	Cc1ccc2c(OC3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL485427	191761	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	417	5	1	5	4.0	Cc1ccc2c(OC3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		10128059	194473	0	None	6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	483	9	1	6	4.3	COc1ccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1NS(C)(=O)=O	10.1021/jm8001444
		CHEMBL495217	194473	0	None	6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor	ChEMBL	483	9	1	6	4.3	COc1ccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1NS(C)(=O)=O	10.1021/jm8001444
		10481003	109730	0	None	1	3	Guinea pig	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	497	6	1	7	5.0	COc1ccc(C(=O)Nc2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm00041a001
		CHEMBL306384	109730	0	None	1	3	Guinea pig	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	497	6	1	7	5.0	COc1ccc(C(=O)Nc2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1N1CCN(C)CC1	10.1021/jm00041a001
		10094227	211301	0	None	794	2	Guinea pig	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	430	9	1	4	5.2	COc1ccc(C(=O)Nc2ccc(-c3ccc(C=O)cc3C)cc2)cc1CCCN(C)C	10.1021/jm00041a001
		CHEMBL72700	211301	0	None	794	2	Guinea pig	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergine	ChEMBL	430	9	1	4	5.2	COc1ccc(C(=O)Nc2ccc(-c3ccc(C=O)cc3C)cc2)cc1CCCN(C)C	10.1021/jm00041a001
		15760	119856	57	None	5	2	Human	8.2	pKi	=	8.2	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	10.1021/jm9805945
		CHEMBL331241	119856	57	None	5	2	Human	8.2	pKi	=	8.2	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	10.1021/jm9805945
		10358173	67088	0	None	-5	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	312	6	1	2	4.2	CCCN(CC(C)C)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL1744039	67088	0	None	-5	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	312	6	1	2	4.2	CCCN(CC(C)C)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		44403095	142012	0	None	-3	6	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	443	4	1	5	3.5	COc1ccc(NC(=O)N2CCN(c3ccc(Cl)cc3)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		CHEMBL372453	142012	0	None	-3	6	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT1D receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	443	4	1	5	3.5	COc1ccc(NC(=O)N2CCN(c3ccc(Cl)cc3)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
		10402263	109976	1	None	-4	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	295	5	1	2	4.0	CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C#N)c3c2C1	10.1021/jm00012a021
		CHEMBL308347	109976	1	None	-4	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	295	5	1	2	4.0	CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C#N)c3c2C1	10.1021/jm00012a021
		70691866	81239	0	None	-23	4	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL2021539	81239	0	None	-23	4	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		CHEMBL2027935	81239	0	None	-23	4	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@@H]1CCc2cccc(CS(=O)(=O)C(F)(F)F)c2C1	10.1021/jm00008a010
		9863333	211144	0	None	-4	9	Human	8.2	pKi	=	8.2	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	352	5	0	4	3.5	COc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm980137o
		CHEMBL71724	211144	0	None	-4	9	Human	8.2	pKi	=	8.2	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	352	5	0	4	3.5	COc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm980137o
		9816035	210912	1	None	104	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	230	2	1	2	2.8	Cc1cc(C(C)(C)C)ccc1CC1=NCCN1	10.1021/jm970513p
		CHEMBL70409	210912	1	None	104	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	230	2	1	2	2.8	Cc1cc(C(C)(C)C)ccc1CC1=NCCN1	10.1021/jm970513p
		10069977	120283	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	407	7	3	5	1.9	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4CN)CC3)cc12	10.1021/jm00018a020
		CHEMBL332063	120283	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	407	7	3	5	1.9	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4CN)CC3)cc12	10.1021/jm00018a020
		9894818	105701	0	None	-223	7	Human	6.2	pKi	=	6.2	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		CHEMBL279436	105701	0	None	-223	7	Human	6.2	pKi	=	6.2	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980506g
		1150	10650	121	None	-3	25	Human	7.2	pKi	=	7.2	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm950498t
		125	10650	121	None	-3	25	Human	7.2	pKi	=	7.2	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm950498t
		CHEMBL6640	10650	121	None	-3	25	Human	7.2	pKi	=	7.2	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm950498t
		DB08653	10650	121	None	-3	25	Human	7.2	pKi	=	7.2	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm950498t
		CHEMBL4445645	220713	18	None	-7	5	Human	5.2	pKi	=	5.2	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL		None	None	None		C[C@@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C[C@H](C)C1(F)F	10.6019/CHEMBL5058646
		CHEMBL4445645	220713	18	None	-7	5	Human	5.2	pKi	=	5.2	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL		None	None	None		C[C@@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C[C@H](C)C1(F)F	10.6019/CHEMBL5058646
		6918515	9390	38	None	-190	7	Human	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
		71	9390	38	None	-190	7	Human	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
		CHEMBL7318	9390	38	None	-190	7	Human	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
		73213196	111237	4	None	-6	13	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104093	111237	4	None	-6	13	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		53324045	63845	0	None	-16	16	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL1644980	63845	0	None	-16	16	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
		76326514	113020	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	295	5	1	2	4.3	CN[C@@H](COc1cccc(Cl)c1Cl)c1ccccc1	10.1007/s00044-009-9164-1
		CHEMBL2260931	113020	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	295	5	1	2	4.3	CN[C@@H](COc1cccc(Cl)c1Cl)c1ccccc1	10.1007/s00044-009-9164-1
		CHEMBL3138903	113020	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	295	5	1	2	4.3	CN[C@@H](COc1cccc(Cl)c1Cl)c1ccccc1	10.1007/s00044-009-9164-1
		44461149	212148	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	421	5	1	5	3.9	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2noc3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL79853	212148	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	421	5	1	5	3.9	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2noc3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		10245352	211012	0	None	-18	4	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	318	6	2	1	4.5	c1ccc(CCCNCC2CCc3ccc4[nH]ccc4c3C2)cc1	10.1021/jm00012a022
		CHEMBL70980	211012	0	None	-18	4	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	318	6	2	1	4.5	c1ccc(CCCNCC2CCc3ccc4[nH]ccc4c3C2)cc1	10.1021/jm00012a022
		70681318	81258	0	None	-9	4	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2c(cccc2CS(=O)(=O)C(F)(F)F)C1	10.1021/jm00008a010
		CHEMBL2021538	81258	0	None	-9	4	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2c(cccc2CS(=O)(=O)C(F)(F)F)C1	10.1021/jm00008a010
		CHEMBL2028033	81258	0	None	-9	4	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand	ChEMBL	335	5	1	3	3.0	CCCN[C@H]1CCc2c(cccc2CS(=O)(=O)C(F)(F)F)C1	10.1021/jm00008a010
		22132503	108757	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	521	9	2	5	4.4	O=C(/C=C/c1c[nH]c2ccccc12)NCCCCN1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1	10.1021/jm000090i
		CHEMBL301475	108757	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	521	9	2	5	4.4	O=C(/C=C/c1c[nH]c2ccccc12)NCCCCN1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1	10.1021/jm000090i
		CHEMBL552599	108757	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	521	9	2	5	4.4	O=C(/C=C/c1c[nH]c2ccccc12)NCCCCN1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1	10.1021/jm000090i
		75306277	116031	0	None	-31	23	Human	7.2	pKi	=	7.2	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		CHEMBL3217984	116031	0	None	-31	23	Human	7.2	pKi	=	7.2	Binding	Binding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1D receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		10115847	98755	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	465	6	1	5	4.9	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL241500	98755	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	465	6	1	5	4.9	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1	10.1016/j.bmcl.2006.11.031
		135458410	173968	0	None	-109	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL429136	173968	0	None	-109	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		9893246	128270	0	None	-102	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	531	9	3	6	4.0	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		CHEMBL358253	128270	0	None	-102	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	531	9	3	6	4.0	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		10788822	109226	0	None	-199	3	Human	6.2	pKi	=	6.2	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	431	6	1	3	4.8	N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccc(F)cc3)CC1)C2	10.1021/jm000090i
		CHEMBL2368611	109226	0	None	-199	3	Human	6.2	pKi	=	6.2	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	431	6	1	3	4.8	N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccc(F)cc3)CC1)C2	10.1021/jm000090i
		CHEMBL3039993	109226	0	None	-199	3	Human	6.2	pKi	=	6.2	Binding	Binding activity against human 5-hydroxytryptamine 1D receptorBinding activity against human 5-hydroxytryptamine 1D receptor	ChEMBL	431	6	1	3	4.8	N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccc(F)cc3)CC1)C2	10.1021/jm000090i
		6918603	214750	1	None	-316	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
		CHEMBL97158	214750	1	None	-316	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
		10835110	121366	0	None	-158	8	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm991151j
		CHEMBL333784	121366	0	None	-158	8	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm991151j
		10249573	214372	0	None	-63	11	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		CHEMBL94984	214372	0	None	-63	11	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
		73213196	111237	4	None	-6	13	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104093	111237	4	None	-6	13	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		11248705	97070	0	None	-251	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238519	97070	0	None	-251	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		44439167	97332	0	None	-63	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238732	97332	0	None	-63	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL4778870	220826	8	None	-1	5	Human	6.2	pKi	=	6.2	Binding	GPCRScan assay: inhibition of 5-HT1DGPCRScan assay: inhibition of 5-HT1D	ChEMBL		None	None	None		CC1CCN(c2ccnc(NCc3cn(C)cn3)n2)CC1	10.6019/CHEMBL4800732
		124247485	170848	8	None	-6	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		CHEMBL4209274	170848	8	None	-6	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
		6603866	104204	17	None	-630	9	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligand	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm00008a010
		CHEMBL26998	104204	17	None	-630	9	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligand	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm00008a010
		CHEMBL541268	104204	17	None	-630	9	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligandIn vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligand	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm00008a010
		9906447	202356	2	None	-8709	13	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human recombinant 5HT1D receptorBinding affinity to human recombinant 5HT1D receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		CHEMBL2031738	202356	2	None	-8709	13	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human recombinant 5HT1D receptorBinding affinity to human recombinant 5HT1D receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		CHEMBL555146	202356	2	None	-8709	13	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human recombinant 5HT1D receptorBinding affinity to human recombinant 5HT1D receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		44461300	111730	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	433	5	1	4	4.2	Cn1cc(C2=CCN(CCC3OCCc4cc(C(N)=O)ccc43)CC2)c2ccc(F)cc21	10.1016/j.bmcl.2004.03.003
		CHEMBL311323	111730	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	433	5	1	4	4.2	Cn1cc(C2=CCN(CCC3OCCc4cc(C(N)=O)ccc43)CC2)c2ccc(F)cc21	10.1016/j.bmcl.2004.03.003
		71459954	85957	0	None	-64	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cellsInhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	495	6	3	3	4.0	O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm049243i
		CHEMBL2113386	85957	0	None	-64	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cellsInhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	495	6	3	3	4.0	O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm049243i
		11056946	115670	0	None	-91	4	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	340	3	2	4	3.7	CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1	10.1021/jm030020m
		CHEMBL321080	115670	0	None	-91	4	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	340	3	2	4	3.7	CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1	10.1021/jm030020m
		4407909	199645	1	None	-11	10	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5182943	199645	1	None	-11	10	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		CHEMBL5221893	199645	1	None	-11	10	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
		122197404	140253	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	433	5	1	4	4.3	C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@H]1OCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		CHEMBL3706924	140253	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	433	5	1	4	4.3	C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@H]1OCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		136118620	83027	0	None	-21	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cellsDisplacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
		CHEMBL2058419	83027	0	None	-21	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cellsDisplacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
		44456400	19606	0	None	-2	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL1188501	19606	0	None	-2	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL2436555	19606	0	None	-2	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL536539	19606	0	None	-2	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]5-CT from human recombinant 5-HT1D receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		10640199	15767	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	330	13	2	2	5.6	CCCCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		CHEMBL109839	15767	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.	ChEMBL	330	13	2	2	5.6	CCCCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		10376496	109676	0	None	-21	4	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	228	3	2	1	3.0	CCCNC1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL305976	109676	0	None	-21	4	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	228	3	2	1	3.0	CCCNC1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		11810310	11490	0	None	-63	4	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	352	3	2	3	3.8	CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1	10.1021/jm030020m
		CHEMBL103550	11490	0	None	-63	4	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	352	3	2	3	3.8	CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1	10.1021/jm030020m
		24839550	144093	14	None	-11	15	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752576	144093	14	None	-11	15	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
		44431532	152015	0	None	10	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	447	5	1	4	4.3	C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		CHEMBL391271	152015	0	None	10	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	447	5	1	4	4.3	C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		18007589	36692	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	270	4	0	3	3.9	CN(C)CCn1ccc2ccc(-c3ccsc3)cc21	10.1016/j.bmcl.2003.09.025
		CHEMBL138821	36692	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)	ChEMBL	270	4	0	3	3.9	CN(C)CCn1ccc2ccc(-c3ccsc3)cc21	10.1016/j.bmcl.2003.09.025
		44376383	62313	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	444	6	2	3	5.1	Cc1ccc(C(=S)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		CHEMBL162049	62313	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	444	6	2	3	5.1	Cc1ccc(C(=S)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		10449461	211238	0	None	-10	4	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	332	6	1	1	5.0	CCCN(CCc1ccccc1)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL72285	211238	0	None	-10	4	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	332	6	1	1	5.0	CCCN(CCc1ccccc1)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		9994674	210935	0	None	-8	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	295	5	1	2	4.0	CCCN(CCC)C1CCc2ccc3[nH]cc(C#N)c3c2C1	10.1021/jm00012a021
		CHEMBL70589	210935	0	None	-8	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	295	5	1	2	4.0	CCCN(CCC)C1CCc2ccc3[nH]cc(C#N)c3c2C1	10.1021/jm00012a021
		9995233	171890	0	None	39	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	304	4	1	2	4.7	CN(C)CCc1c[nH]c2ccc(-c3ccc(Cl)s3)cc12	10.1016/s0960-894x(00)00133-5
		CHEMBL422737	171890	0	None	39	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	304	4	1	2	4.7	CN(C)CCc1c[nH]c2ccc(-c3ccc(Cl)s3)cc12	10.1016/s0960-894x(00)00133-5
		44376262	173876	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	444	7	2	4	4.2	COc1ccc(C(=O)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		CHEMBL428991	173876	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	444	7	2	4	4.2	COc1ccc(C(=O)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		10216744	181692	0	None	7	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	436	7	0	3	6.5	Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccccc5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		CHEMBL456459	181692	0	None	7	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells	ChEMBL	436	7	0	3	6.5	Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccccc5)c4)CC3)cccc2n1	10.1016/j.bmcl.2008.11.052
		11774585	75948	0	None	31	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	424	7	0	6	3.8	Cc1ccc2c(OCCN3CCN(Cc4ccc(F)c([N+](=O)[O-])c4)CC3)cccc2n1	10.1021/jm049039v
		CHEMBL192536	75948	0	None	31	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	ChEMBL	424	7	0	6	3.8	Cc1ccc2c(OCCN3CCN(Cc4ccc(F)c([N+](=O)[O-])c4)CC3)cccc2n1	10.1021/jm049039v
		44588721	191125	0	None	6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	419	7	1	6	3.3	Cc1ccc2c(OCCN3CC(COc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL484387	191125	0	None	6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	419	7	1	6	3.3	Cc1ccc2c(OCCN3CC(COc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1	10.1016/j.bmcl.2008.08.110
		44404260	79127	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	519	5	0	7	4.6	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C(C)C)CC5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		CHEMBL198488	79127	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	519	5	0	7	4.6	CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C(C)C)CC5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		44404264	79317	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	505	4	1	7	4.2	CCc1c(C(=O)N2CCc3cc4ccnc(N5C[C@H](C)N[C@H](C)C5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		CHEMBL199144	79317	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	505	4	1	7	4.2	CCc1c(C(=O)N2CCc3cc4ccnc(N5C[C@H](C)N[C@H](C)C5)c4cc32)cnn1-c1ccc(C#N)cc1	10.1016/j.bmcl.2005.06.042
		44404244	79326	0	None	-3	3	Human	8.1	pKi	=	8.1	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	444	2	0	5	4.1	Cc1cc(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)c(C(F)(F)F)o1	10.1016/j.bmcl.2005.06.042
		CHEMBL199175	79326	0	None	-3	3	Human	8.1	pKi	=	8.1	Binding	Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligand	ChEMBL	444	2	0	5	4.1	Cc1cc(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)c(C(F)(F)F)o1	10.1016/j.bmcl.2005.06.042
		19066205	18154	0	None	-8	3	Human	7.2	pKi	=	7.2	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	439	5	1	6	2.8	COc1cccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)c1	10.1016/S0960-894X(97)10164-0
		CHEMBL108722	18154	0	None	-8	3	Human	7.2	pKi	=	7.2	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	439	5	1	6	2.8	COc1cccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)c1	10.1016/S0960-894X(97)10164-0
		CHEMBL1179986	18154	0	None	-8	3	Human	7.2	pKi	=	7.2	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	439	5	1	6	2.8	COc1cccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)c1	10.1016/S0960-894X(97)10164-0
		16006607	102447	4	None	-69	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	219	2	2	4	2.1	CC(C)Oc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		CHEMBL258075	102447	4	None	-69	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	219	2	2	4	2.1	CC(C)Oc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
		113	8633	14	None	-39	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	375	7	2	4	4.2	CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C	10.1021/jm9702948
		128018	8633	14	None	-39	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	375	7	2	4	4.2	CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C	10.1021/jm9702948
		CHEMBL119264	8633	14	None	-39	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligandBinding affinity for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]5-CT as radioligand	ChEMBL	375	7	2	4	4.2	CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C	10.1021/jm9702948
		44455426	161928	0	None	-10	12	Human	6.2	pKi	=	6.2	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL402143	161928	0	None	-10	12	Human	6.2	pKi	=	6.2	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		44461416	111136	0	None	6	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	430	5	1	3	4.9	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2ccc3cc(F)ccc3c2)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL310082	111136	0	None	6	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	430	5	1	3	4.9	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2ccc3cc(F)ccc3c2)CC1	10.1016/j.bmcl.2004.03.003
		44582676	196558	0	None	-5	17	Human	6.2	pKi	=	6.2	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL516088	196558	0	None	-5	17	Human	6.2	pKi	=	6.2	Binding	Inhibition of human cloned 5HT1D receptor by competitive binding experimentInhibition of human cloned 5HT1D receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		3016908	211223	24	None	47	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	202	2	1	2	2.2	Cc1cc(C)c(CC2=NCCN2)c(C)c1	10.1021/jm970513p
		CHEMBL72178	211223	24	None	47	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	202	2	1	2	2.2	Cc1cc(C)c(CC2=NCCN2)c(C)c1	10.1021/jm970513p
		6918542	211703	24	None	-363	10	Human	6.1	pKi	=	6.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		CHEMBL76237	211703	24	None	-363	10	Human	6.1	pKi	=	6.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		10020895	11477	0	None	-95	8	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	352	3	2	3	3.8	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1	10.1021/jm030020m
		CHEMBL103479	11477	0	None	-95	8	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	352	3	2	3	3.8	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1	10.1021/jm030020m
		9947817	11819	0	None	-131	9	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	286	3	2	3	2.7	CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		CHEMBL105261	11819	0	None	-131	9	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	286	3	2	3	2.7	CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		9795333	109852	0	None	21	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	266	2	1	2	2.6	Cc1cc(Br)cc(C)c1CC1=NCCN1	10.1016/j.bmcl.2004.06.085
		CHEMBL307408	109852	0	None	21	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor	ChEMBL	266	2	1	2	2.6	Cc1cc(Br)cc(C)c1CC1=NCCN1	10.1016/j.bmcl.2004.06.085
		44461247	111533	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	422	5	2	4	3.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CCN(c2c[nH]c3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL310744	111533	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	422	5	2	4	3.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CCN(c2c[nH]c3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		9795333	109852	0	None	21	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	266	2	1	2	2.6	Cc1cc(Br)cc(C)c1CC1=NCCN1	10.1021/jm970513p
		CHEMBL307408	109852	0	None	21	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	266	2	1	2	2.6	Cc1cc(Br)cc(C)c1CC1=NCCN1	10.1021/jm970513p
		44376362	171675	0	None	10	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	4	2	2	3.2	C1=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CCNC1	10.1016/j.bmcl.2003.11.023
		CHEMBL422192	171675	0	None	10	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	295	4	2	2	3.2	C1=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CCNC1	10.1016/j.bmcl.2003.11.023
		CHEMBL346649	126407	0	None	-199	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	604	11	2	9	4.9	CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		11727140	116170	0	None	-67	4	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	326	3	2	3	3.5	CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCC4)nc23)CC1	10.1021/jm030020m
		CHEMBL321967	116170	0	None	-67	4	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	326	3	2	3	3.5	CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCC4)nc23)CC1	10.1021/jm030020m
		44581973	182380	0	None	-346	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5HT from 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from 5HT1D receptor expressed in CHO cells	ChEMBL	513	6	2	6	4.6	Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		CHEMBL458002	182380	0	None	-346	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5HT from 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from 5HT1D receptor expressed in CHO cells	ChEMBL	513	6	2	6	4.6	Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
		135458428	162313	0	None	-26	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	255	3	2	4	2.2	COc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
		CHEMBL404248	162313	0	None	-26	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	255	3	2	4	2.2	COc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
		10265814	210804	0	None	-30	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	282	5	1	1	4.1	CCCN(CC1CC1)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL69729	210804	0	None	-30	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	282	5	1	1	4.1	CCCN(CC1CC1)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00012a022
		CHEMBL151825	51149	0	None	-158	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	629	12	2	10	4.8	COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)N=C(C)/C(=C(/O)OCCC#N)C2c2ccc([N+](=O)[O-])cc2)CC1	10.1021/jm980506g
		145988693	173945	0	None	-30	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4291048	173945	0	None	-30	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		127026052	144331	0	None	-45	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754496	144331	0	None	-45	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT 1D (unknown origin) by competition binding assayBinding affinity to 5-HT 1D (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		44310169	211136	0	None	-8	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	264	5	1	2	3.4	CCCN(CCC)C1CCc2c(ccc(F)c2N)C1	10.1021/jm00012a021
		CHEMBL71676	211136	0	None	-8	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	264	5	1	2	3.4	CCCN(CCC)C1CCc2c(ccc(F)c2N)C1	10.1021/jm00012a021
		10354282	210769	0	None	-97	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	240	1	1	1	3.1	c1cc2c3c(ccc2[nH]1)CCC(N1CCCC1)C3	10.1021/jm00012a022
		CHEMBL69560	210769	0	None	-97	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	240	1	1	1	3.1	c1cc2c3c(ccc2[nH]1)CCC(N1CCCC1)C3	10.1021/jm00012a022
		10326069	46070	1	None	-478	9	Human	5.1	pKi	=	5.1	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		CHEMBL147077	46070	1	None	-478	9	Human	5.1	pKi	=	5.1	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		76330159	113021	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	295	5	1	2	4.3	CN[C@H](COc1cccc(Cl)c1Cl)c1ccccc1	10.1007/s00044-009-9164-1
		CHEMBL2260932	113021	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	295	5	1	2	4.3	CN[C@H](COc1cccc(Cl)c1Cl)c1ccccc1	10.1007/s00044-009-9164-1
		CHEMBL3138904	113021	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	295	5	1	2	4.3	CN[C@H](COc1cccc(Cl)c1Cl)c1ccccc1	10.1007/s00044-009-9164-1
		135453290	140384	33	None	-2630	8	Human	5.1	pKi	=	5.1	Binding	Inhibitory activity against 5HT1D receptorInhibitory activity against 5HT1D receptor	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
		CHEMBL371300	140384	33	None	-2630	8	Human	5.1	pKi	=	5.1	Binding	Inhibitory activity against 5HT1D receptorInhibitory activity against 5HT1D receptor	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
		24882192	195581	0	None	125	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	714	10	4	4	8.9	O=C(Nc1ccc2[nH]cc(C3CCN(CCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL505954	195581	0	None	125	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	ChEMBL	714	10	4	4	8.9	O=C(Nc1ccc2[nH]cc(C3CCN(CCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		44402871	175376	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	462	3	1	4	5.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(Cl)c1Cl)CC2	10.1016/j.bmcl.2005.07.085
		CHEMBL435936	175376	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity against cloned human 5-hydroxytryptamine 1D receptorBinding affinity against cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	462	3	1	4	5.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(Cl)c1Cl)CC2	10.1016/j.bmcl.2005.07.085
		44330234	214963	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	357	3	2	4	3.0	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccc(F)cc1)[C@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		CHEMBL98388	214963	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement.	ChEMBL	357	3	2	4	3.0	CC(=O)c1ccc2c(c1)[C@H](NC(=O)c1ccc(F)cc1)[C@H](O)C(C)(C)O2	10.1016/s0960-894x(98)00728-8
		9804612	97310	0	None	-19	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL238730	97310	0	None	-19	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
		10161027	98751	0	None	-3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL241499	98751	0	None	-3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	449	6	1	5	4.3	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1	10.1016/j.bmcl.2006.11.031
		44588720	191124	0	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	445	6	1	5	4.6	Cc1ccc2c(OC(C)CN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		CHEMBL484386	191124	0	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	445	6	1	5	4.6	Cc1ccc2c(OC(C)CN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
		10115848	97545	0	None	-501	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	465	6	1	5	4.9	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL239166	97545	0	None	-501	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	465	6	1	5	4.9	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		44439165	152531	0	None	-316	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		CHEMBL391661	152531	0	None	-316	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
		9860595	16857	2	None	77	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	283	4	1	2	3.0	CN(C)CCc1c[nH]c2ccc(C3=CCN(C)CC3)cc12	10.1016/s0960-894x(03)00779-0
		CHEMBL115415	16857	2	None	77	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	283	4	1	2	3.0	CN(C)CCc1c[nH]c2ccc(C3=CCN(C)CC3)cc12	10.1016/s0960-894x(03)00779-0
		9860595	16857	2	None	77	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	283	4	1	2	3.0	CN(C)CCc1c[nH]c2ccc(C3=CCN(C)CC3)cc12	10.1016/j.bmcl.2003.11.023
		CHEMBL115415	16857	2	None	77	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	283	4	1	2	3.0	CN(C)CCc1c[nH]c2ccc(C3=CCN(C)CC3)cc12	10.1016/j.bmcl.2003.11.023
		9802187	212627	0	None	-4	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1	10.1016/j.bmcl.2007.03.101
		CHEMBL83617	212627	0	None	-4	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	419	5	2	3	4.2	NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1	10.1016/j.bmcl.2007.03.101
		11809037	11865	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	309	3	1	5	1.7	CN1CCC(c2c[nH]c3ccc(OS(C)(=O)=O)nc23)CC1	10.1021/jm030020m
		CHEMBL105556	11865	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	309	3	1	5	1.7	CN1CCC(c2c[nH]c3ccc(OS(C)(=O)=O)nc23)CC1	10.1021/jm030020m
		44383738	67040	0	None	13	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	326	5	2	3	3.9	OC[C@@H]1CCCN1CCc1c[nH]c2ccc(-c3cccs3)cc12	10.1016/s0960-894x(00)00133-5
		CHEMBL174141	67040	0	None	13	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor	ChEMBL	326	5	2	3	3.9	OC[C@@H]1CCCN1CCc1c[nH]c2ccc(-c3cccs3)cc12	10.1016/s0960-894x(00)00133-5
		10088038	211135	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	330	7	1	1	5.2	CCCc1c[nH]c2c(F)cc3c(c12)CC(N(CCC)CCC)CC3	10.1021/jm00012a021
		CHEMBL71663	211135	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	330	7	1	1	5.2	CCCc1c[nH]c2c(F)cc3c(c12)CC(N(CCC)CCC)CC3	10.1021/jm00012a021
		CHEMBL5084249	221684	0	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
		44461249	212130	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	421	5	2	3	4.3	NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2c[nH]c3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		CHEMBL79674	212130	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand	ChEMBL	421	5	2	3	4.3	NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2c[nH]c3cc(F)ccc23)CC1	10.1016/j.bmcl.2004.03.003
		2543	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00018a020
		5358	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00018a020
		54	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00018a020
		CHEMBL128	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00018a020
		DB00669	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00018a020
		2543	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
		5358	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
		54	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
		CHEMBL128	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
		DB00669	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/0960-894X(95)00091-7
		44376722	62268	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	428	6	2	3	4.5	Cc1ccc(C(=O)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		CHEMBL162012	62268	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	428	6	2	3	4.5	Cc1ccc(C(=O)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1	10.1016/j.bmcl.2003.11.023
		11098166	116564	0	None	-3	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	287	2	3	3	2.1	CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		CHEMBL323264	116564	0	None	-3	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	287	2	3	3	2.1	CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1	10.1021/jm030020m
		10358224	211099	0	None	-3	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	313	5	1	2	4.2	CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C#N)c3c2C1	10.1021/jm00012a021
		CHEMBL71474	211099	0	None	-3	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	313	5	1	2	4.2	CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C#N)c3c2C1	10.1021/jm00012a021
		44376516	63158	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	414	6	2	3	4.2	O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccccc1	10.1016/j.bmcl.2003.11.023
		CHEMBL163151	63158	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	414	6	2	3	4.2	O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccccc1	10.1016/j.bmcl.2003.11.023
		2543	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(98)00090-0
		5358	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(98)00090-0
		54	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(98)00090-0
		CHEMBL128	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(98)00090-0
		DB00669	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligandIn vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/s0960-894x(98)00090-0
		23288790	210743	0	None	16	6	Human	8.1	pKi	=	8.1	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	395	6	1	5	2.6	COc1ccc(N2CCN(CCC3OCCc4cc(C(N)=O)ccc43)CC2)cc1	10.1021/jm980137o
		CHEMBL69385	210743	0	None	16	6	Human	8.1	pKi	=	8.1	Binding	The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cellsThe compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells	ChEMBL	395	6	1	5	2.6	COc1ccc(N2CCN(CCC3OCCc4cc(C(N)=O)ccc43)CC2)cc1	10.1021/jm980137o
		44376541	172167	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	464	6	2	3	5.4	O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1cccc2ccccc12	10.1016/j.bmcl.2003.11.023
		CHEMBL423789	172167	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	464	6	2	3	5.4	O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1cccc2ccccc12	10.1016/j.bmcl.2003.11.023
		11033734	16493	1	None	-204	6	Human	7.1	pKi	=	7.1	Binding	The binding affinity at 5-hydroxytryptamine 1D receptor was determined using [3H]5-CTThe binding affinity at 5-hydroxytryptamine 1D receptor was determined using [3H]5-CT	ChEMBL	294	1	0	3	3.1	COc1cccc2c1N1CCN(C)C[C@H]1c1ccccc1C2	10.1021/jm010566d
		CHEMBL113238	16493	1	None	-204	6	Human	7.1	pKi	=	7.1	Binding	The binding affinity at 5-hydroxytryptamine 1D receptor was determined using [3H]5-CTThe binding affinity at 5-hydroxytryptamine 1D receptor was determined using [3H]5-CT	ChEMBL	294	1	0	3	3.1	COc1cccc2c1N1CCN(C)C[C@H]1c1ccccc1C2	10.1021/jm010566d
		145976085	170444	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		CHEMBL4204576	170444	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
		11046087	11719	0	None	-109	4	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	340	3	2	4	3.7	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1	10.1021/jm030020m
		CHEMBL104753	11719	0	None	-109	4	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	340	3	2	4	3.7	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1	10.1021/jm030020m
		130442480	182049	0	None	-100	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	182049	0	None	-100	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		135458427	178332	0	None	-19	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	283	4	2	4	3.0	CC(C)Oc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
		CHEMBL446459	178332	0	None	-19	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor	ChEMBL	283	4	2	4	3.0	CC(C)Oc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
		11110452	11902	0	None	-128	4	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	335	3	2	4	3.0	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1	10.1021/jm030020m
		CHEMBL105722	11902	0	None	-128	4	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	335	3	2	4	3.0	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1	10.1021/jm030020m
		10971452	11665	0	None	-20	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	402	3	2	3	4.9	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(Cl)cc4Cl)nc23)CC1	10.1021/jm030020m
		CHEMBL104496	11665	0	None	-20	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	402	3	2	3	4.9	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(Cl)cc4Cl)nc23)CC1	10.1021/jm030020m
		53325242	63844	0	None	-4	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL1644978	63844	0	None	-4	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		21509921	111235	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	111235	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		21509921	111235	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	111235	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		145972796	171375	0	None	-7	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	236	3	2	4	2.0	CNc1ccccc1C1=N[C@@H](CO)[C@H](C)S1	10.1021/acs.jnatprod.7b00317
		CHEMBL4215741	171375	0	None	-7	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	236	3	2	4	2.0	CNc1ccccc1C1=N[C@@H](CO)[C@H](C)S1	10.1021/acs.jnatprod.7b00317
		145990586	173622	0	None	-66	11	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT1D receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT1D receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
		CHEMBL4285281	173622	0	None	-66	11	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT1D receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT1D receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
		3649661	144997	7	None	-1174	8	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		CHEMBL3770106	144997	7	None	-1174	8	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]GR127543 from 5-HT1D receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
		CHEMBL5074190	221093	0	None	-33	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT1DR (unknown origin)Binding affinity to 5-HT1DR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
		9816604	211202	2	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor at a dose of 5 mg/kgBinding affinity towards human 5-hydroxytryptamine 1D receptor at a dose of 5 mg/kg	ChEMBL	258	2	0	2	3.5	Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1C	10.1016/j.bmcl.2004.06.085
		CHEMBL72107	211202	2	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor at a dose of 5 mg/kgBinding affinity towards human 5-hydroxytryptamine 1D receptor at a dose of 5 mg/kg	ChEMBL	258	2	0	2	3.5	Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1C	10.1016/j.bmcl.2004.06.085
		9816604	211202	2	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	258	2	0	2	3.5	Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1C	10.1021/jm970513p
		CHEMBL72107	211202	2	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	ChEMBL	258	2	0	2	3.5	Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1C	10.1021/jm970513p
		145967795	171602	0	None	-5	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2ccsc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		CHEMBL4218679	171602	0	None	-5	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2ccsc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
		9997421	210916	0	None	-3	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	341	7	2	3	2.8	CCCN(CCC)C1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1	10.1021/jm00012a021
		CHEMBL70431	210916	0	None	-3	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.	ChEMBL	341	7	2	3	2.8	CCCN(CCC)C1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1	10.1021/jm00012a021
		10326069	46070	1	None	-478	9	Human	5.1	pKi	=	5.1	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		CHEMBL147077	46070	1	None	-478	9	Human	5.1	pKi	=	5.1	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		19066203	18861	0	None	-47	3	Human	7.1	pKi	=	7.1	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	437	4	1	5	3.4	COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL1183904	18861	0	None	-47	3	Human	7.1	pKi	=	7.1	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	437	4	1	5	3.4	COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL323986	18861	0	None	-47	3	Human	7.1	pKi	=	7.1	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	437	4	1	5	3.4	COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		44431533	94801	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	447	5	1	4	4.3	C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@H]1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		CHEMBL234448	94801	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsDisplacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cells	ChEMBL	447	5	1	4	4.3	C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@H]1OCCc2cc(C(N)=O)ccc21	10.1016/j.bmcl.2007.03.101
		21830793	98610	10	None	-588	46	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		CHEMBL2413154	98610	10	None	-588	46	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		10326069	46070	1	None	-478	9	Human	5.1	pKi	=	5.1	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		CHEMBL147077	46070	1	None	-478	9	Human	5.1	pKi	=	5.1	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		136118661	83032	0	None	-9	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cellsDisplacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
		CHEMBL2058429	83032	0	None	-9	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cellsDisplacement of [3H]5-CT from human recombinant 5HT1D receptor expressed in HEKT cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
		130442572	178687	0	None	-190	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	178687	0	None	-190	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		142601343	192382	0	None	-30	7	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		CHEMBL4863868	192382	0	None	-30	7	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
		9862256	213899	0	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		CHEMBL92139	213899	0	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		44376492	126764	0	None	11	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	469	6	1	3	4.9	O=S(=O)(c1ccc(Cl)cc1)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1	10.1016/j.bmcl.2003.11.023
		CHEMBL349903	126764	0	None	11	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	469	6	1	3	4.9	O=S(=O)(c1ccc(Cl)cc1)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1	10.1016/j.bmcl.2003.11.023
		9803032	198232	0	None	-15	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	435	7	0	4	4.4	COc1ccccc1N1CCN(CC[C@@H](C(=O)N2CCCCCC2)c2ccccc2)CC1	10.1021/acs.jmedchem.2c00633
		CHEMBL5193178	198232	0	None	-15	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT1D receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT1D receptor (unknown origin) assessed as inhibition constant	ChEMBL	435	7	0	4	4.4	COc1ccccc1N1CCN(CC[C@@H](C(=O)N2CCCCCC2)c2ccccc2)CC1	10.1021/acs.jmedchem.2c00633
		44376272	127007	0	None	7	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	430	6	2	3	4.8	S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccccc1	10.1016/j.bmcl.2003.11.023
		CHEMBL352181	127007	0	None	7	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptorBinding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor	ChEMBL	430	6	2	3	4.8	S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccccc1	10.1016/j.bmcl.2003.11.023
		20810	15957	22	None	-7	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	202	3	2	2	1.9	CC(=O)c1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		CHEMBL110317	15957	22	None	-7	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	202	3	2	2	1.9	CC(=O)c1ccc2[nH]cc(CCN)c2c1	10.1021/jm950498t
		9981270	172053	0	None	-3	4	Human	8.0	pKi	=	8.0	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	451	9	1	4	4.5	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		CHEMBL423127	172053	0	None	-3	4	Human	8.0	pKi	=	8.0	Binding	In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligandIn vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand	ChEMBL	451	9	1	4	4.5	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]cc(C=O)c3c2C1	10.1021/jm00012a022
		10478367	78445	0	None	-19	7	Human	7.1	pKi	=	7.1	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL196370	78445	0	None	-19	7	Human	7.1	pKi	=	7.1	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		CHEMBL430500	78445	0	None	-19	7	Human	7.1	pKi	=	7.1	Binding	Affinity for 5-hydroxytryptamine 1D receptor subtypeAffinity for 5-hydroxytryptamine 1D receptor subtype	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/S0960-894X(97)10164-0
		10946905	170461	0	None	-102	4	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	312	3	2	3	3.1	CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1	10.1021/jm030020m
		CHEMBL420475	170461	0	None	-102	4	Human	6.1	pKi	=	6.1	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	312	3	2	3	3.1	CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1	10.1021/jm030020m
		117209857	191917	1	None	-21	8	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		CHEMBL4856702	191917	1	None	-21	8	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT1D receptor (unknown origin)Binding affinity to 5HT1D receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
		56649650	74633	0	None	-104	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		CHEMBL1910141	74633	0	None	-104	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
		CHEMBL4520788	220754	10	None	-4	25	Human	7.0	pKi	=	7.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR1DSelectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR1D	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		10925382	11788	0	None	-72	4	Human	6.0	pKi	=	6.0	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	324	3	2	4	3.2	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1	10.1021/jm030020m
		CHEMBL105091	11788	0	None	-72	4	Human	6.0	pKi	=	6.0	Binding	In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor	ChEMBL	324	3	2	4	3.2	CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1	10.1021/jm030020m
		75201901	173204	19	None	-691	24	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	173204	19	None	-691	24	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		16006605	104768	3	None	-407	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL272781	104768	3	None	-407	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT1D receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		145964150	171085	0	None	-4	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	279	6	1	4	3.1	CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
		CHEMBL4212246	171085	0	None	-4	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	279	6	1	4	3.1	CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
		28338386	113002	2	None	2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	219	4	1	2	2.6	CNCCOc1ccc(Cl)cc1Cl	10.1007/s00044-009-9164-1
		CHEMBL2260921	113002	2	None	2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	219	4	1	2	2.6	CNCCOc1ccc(Cl)cc1Cl	10.1007/s00044-009-9164-1
		CHEMBL3138811	113002	2	None	2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assayBinding affinity to Homo sapiens (human) 5HT1D receptor by radioligand binding assay	ChEMBL	219	4	1	2	2.6	CNCCOc1ccc(Cl)cc1Cl	10.1007/s00044-009-9164-1
		9867475	24785	0	None	-32	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	432	7	0	5	4.2	CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		CHEMBL126340	24785	0	None	-32	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand	ChEMBL	432	7	0	5	4.2	CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1	10.1021/jm010943m
		44339072	118155	1	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	274	5	1	3	2.8	CC(C)C(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm950498t
		CHEMBL327103	118155	1	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenateBinding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate	ChEMBL	274	5	1	3	2.8	CC(C)C(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm950498t
		1524	8962	96	None	-257	51	Human	8.2	pIC50	=	8.2	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	None	-257	51	Human	8.2	pIC50	=	8.2	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	None	-257	51	Human	8.2	pIC50	=	8.2	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	None	-257	51	Human	8.2	pIC50	=	8.2	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	None	-257	51	Human	8.2	pIC50	=	8.2	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	None	-257	51	Human	8.2	pIC50	=	8.2	Binding	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		2543	10479	68	None	-2	32	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	None	-2	32	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	None	-2	32	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	None	-2	32	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	None	-2	32	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		123606	7140	70	None	-1	3	Human	7.9	pIC50	=	7.9	Binding	Affinity of almotriptan at recombinant h5-HT<sub>1D</sub> receptors expressed in HeLa cells, determined in a radioligand displacement assay using [<sup>125</sup>I]GTI as tracer.Affinity of almotriptan at recombinant h5-HT<sub>1D</sub> receptors expressed in HeLa cells, determined in a radioligand displacement assay using [<sup>125</sup>I]GTI as tracer.	Guide to Pharmacology	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	11134654
		128	7140	70	None	-1	3	Human	7.9	pIC50	=	7.9	Binding	Affinity of almotriptan at recombinant h5-HT<sub>1D</sub> receptors expressed in HeLa cells, determined in a radioligand displacement assay using [<sup>125</sup>I]GTI as tracer.Affinity of almotriptan at recombinant h5-HT<sub>1D</sub> receptors expressed in HeLa cells, determined in a radioligand displacement assay using [<sup>125</sup>I]GTI as tracer.	Guide to Pharmacology	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	11134654
		7110	7140	70	None	-1	3	Human	7.9	pIC50	=	7.9	Binding	Affinity of almotriptan at recombinant h5-HT<sub>1D</sub> receptors expressed in HeLa cells, determined in a radioligand displacement assay using [<sup>125</sup>I]GTI as tracer.Affinity of almotriptan at recombinant h5-HT<sub>1D</sub> receptors expressed in HeLa cells, determined in a radioligand displacement assay using [<sup>125</sup>I]GTI as tracer.	Guide to Pharmacology	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	11134654
		CHEMBL1505	7140	70	None	-1	3	Human	7.9	pIC50	=	7.9	Binding	Affinity of almotriptan at recombinant h5-HT<sub>1D</sub> receptors expressed in HeLa cells, determined in a radioligand displacement assay using [<sup>125</sup>I]GTI as tracer.Affinity of almotriptan at recombinant h5-HT<sub>1D</sub> receptors expressed in HeLa cells, determined in a radioligand displacement assay using [<sup>125</sup>I]GTI as tracer.	Guide to Pharmacology	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	11134654
		DB00918	7140	70	None	-1	3	Human	7.9	pIC50	=	7.9	Binding	Affinity of almotriptan at recombinant h5-HT<sub>1D</sub> receptors expressed in HeLa cells, determined in a radioligand displacement assay using [<sup>125</sup>I]GTI as tracer.Affinity of almotriptan at recombinant h5-HT<sub>1D</sub> receptors expressed in HeLa cells, determined in a radioligand displacement assay using [<sup>125</sup>I]GTI as tracer.	Guide to Pharmacology	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	11134654
		40	8329	58	None	2	5	Human	8.0	pKd	=	8.0	Binding	GRAC: human 5-HT1D probeGRAC: human 5-HT1D probe	Drug Central	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	None
		77993	8329	58	None	2	5	Human	8.0	pKd	=	8.0	Binding	GRAC: human 5-HT1D probeGRAC: human 5-HT1D probe	Drug Central	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	None
		995	8329	58	None	2	5	Human	8.0	pKd	=	8.0	Binding	GRAC: human 5-HT1D probeGRAC: human 5-HT1D probe	Drug Central	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	None
		CHEMBL1510	8329	58	None	2	5	Human	8.0	pKd	=	8.0	Binding	GRAC: human 5-HT1D probeGRAC: human 5-HT1D probe	Drug Central	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	None
		DB00216	8329	58	None	2	5	Human	8.0	pKd	=	8.0	Binding	GRAC: human 5-HT1D probeGRAC: human 5-HT1D probe	Drug Central	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	None
		117	7141	19	None	1	2	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	9605573
		120	7141	19	None	1	2	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	9605573
		66004	7141	19	None	1	2	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	9605573
		CHEMBL88240	7141	19	None	1	2	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	9605573
		1220	6975	55	None	-95	44	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10431754
		31	6975	55	None	-95	44	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10431754
		7	6975	55	None	-95	44	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10431754
		CHEMBL56	6975	55	None	-95	44	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10431754
		None	222717	0	3H-5HT	2	21	Rat	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		11954224	222732	0	3H-5HT	12	59	Rat	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		11797998	42466	0	UNDEFINED	-1	3	Human	10.0	pKi	=	10.0	Binding	NoneNone	PDSP KiDatabase	454	10	4	4	4.8	NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12	None
		CHEMBL144030	42466	0	UNDEFINED	-1	3	Human	10.0	pKi	=	10.0	Binding	NoneNone	PDSP KiDatabase	454	10	4	4	4.8	NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12	None
		107780	8625	54	3H-5HT	-1	18	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		14	8625	54	3H-5HT	-1	18	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL15928	8625	54	3H-5HT	-1	18	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		None	222717	0	3H-5HT	-2	21	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		24882193	195428	0	UNDEFINED	263	2	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL503468	195428	0	UNDEFINED	263	2	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		11954224	222732	0	3H-GR125743	-28	59	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		1809	6922	32	3H-5CT	-10	37	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5CT	-10	37	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5CT	-10	37	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	6922	32	3H-5HT	-91	37	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-91	37	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-91	37	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		44279525	112289	0	UNDEFINED	1	3	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	444	8	2	5	4.0	CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1	None
		CHEMBL31217	112289	0	UNDEFINED	1	3	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	444	8	2	5	4.0	CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1	None
		5	6927	72	UNDEFINED	-6	53	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	UNDEFINED	-6	53	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	UNDEFINED	-6	53	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	UNDEFINED	-6	53	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		4106	9280	22	3H-5HT	-1	33	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-5HT	-1	33	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-5HT	-1	33	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-5HT	-1	33	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		133	9274	52	3H-5HT	-3	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	3H-5HT	-3	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	3H-5HT	-3	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	3H-5HT	-3	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	3H-5HT	-3	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		4106	9280	22	3H-5HT	-1	33	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-5HT	-1	33	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-5HT	-1	33	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-5HT	-1	33	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		24881617	195105	0	UNDEFINED	165	2	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	756	13	4	4	10.1	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL500737	195105	0	UNDEFINED	165	2	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	756	13	4	4	10.1	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		133	9274	52	3H-5HT	-3	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	3H-5HT	-3	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	3H-5HT	-3	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	3H-5HT	-3	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	3H-5HT	-3	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		12312583	222796	0	3H-5HT	-1	3	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	254	1	2	2	2.0	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)CO	None
		1809	6922	32	3H-5HT	-10	37	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-10	37	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-10	37	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		107780	8625	54	3H-5HT	-1	18	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		14	8625	54	3H-5HT	-1	18	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL15928	8625	54	3H-5HT	-1	18	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		1809	6922	32	3H-5HT	-16	37	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-16	37	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-16	37	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		133	9274	52	3H-5HT	-1	43	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	3H-5HT	-1	43	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	3H-5HT	-1	43	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	3H-5HT	-1	43	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	3H-5HT	-1	43	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		133	9274	52	3H-5HT	-1	43	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	3H-5HT	-1	43	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	3H-5HT	-1	43	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	3H-5HT	-1	43	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	3H-5HT	-1	43	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		133	9274	52	3H-5HT	-2	43	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	3H-5HT	-2	43	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	3H-5HT	-2	43	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	3H-5HT	-2	43	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	3H-5HT	-2	43	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		133	9274	52	3H-5HT	-2	43	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	3H-5HT	-2	43	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	3H-5HT	-2	43	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	3H-5HT	-2	43	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	3H-5HT	-2	43	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		9832057	59089	0	UNDEFINED	-1	3	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	692	16	2	6	4.8	CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12	None
		CHEMBL158941	59089	0	UNDEFINED	-1	3	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	692	16	2	6	4.8	CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12	None
		24881752	178538	0	UNDEFINED	1	2	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	638	14	4	4	8.4	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		CHEMBL446745	178538	0	UNDEFINED	1	2	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	638	14	4	4	8.4	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		24881202	179365	0	UNDEFINED	1	2	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	596	11	4	4	7.2	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		CHEMBL448902	179365	0	UNDEFINED	1	2	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	596	11	4	4	7.2	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		11954224	222732	0	3H-5HT	-12	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		None	224023	0	UNDEFINED	-	1	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	409	6	1	5	2.9	CNC(=O)C1=CC2=C(C=C1)C(OCC2)CCN3CCN(CC3)C4=CC=C(C=C4)OC	None
		1809	6922	32	3H-5HT	-10	37	Dog	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-10	37	Dog	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-10	37	Dog	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	6922	32	3H-5HT	-10	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-10	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-10	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		24881689	176911	0	UNDEFINED	-1	2	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	554	8	4	4	6.0	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		CHEMBL444404	176911	0	UNDEFINED	-1	2	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	554	8	4	4	6.0	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		24881203	180010	0	UNDEFINED	-1	2	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	624	13	4	4	8.0	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		CHEMBL452387	180010	0	UNDEFINED	-1	2	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	624	13	4	4	8.0	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		1809	6922	32	3H-5HT	-10	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-10	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-10	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1588	9105	27	3H-GR-125743	-48	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	9105	27	3H-GR-125743	-48	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	9105	27	3H-GR-125743	-48	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	9105	27	3H-GR-125743	-48	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	9105	27	3H-GR-125743	-48	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1809	6922	32	3H-5HT	-10	37	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-10	37	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-10	37	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		24881618	195566	0	UNDEFINED	125	2	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	798	16	4	4	11.2	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL505750	195566	0	UNDEFINED	125	2	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	798	16	4	4	11.2	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		11954224	222732	0	3H-GR-125743	-28	59	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		1809	6922	32	3H-5HT	-16	37	Bovine	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-16	37	Bovine	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-16	37	Bovine	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		133	9274	52	3H-GR-125743	-3	43	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	3H-GR-125743	-3	43	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	3H-GR-125743	-3	43	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	3H-GR-125743	-3	43	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	3H-GR-125743	-3	43	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		12312583	222796	0	3H-5HT	-1	3	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	254	1	2	2	2.0	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)CO	None
		5	6927	72	3H-5HT	-6	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-6	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-6	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-6	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		2543	10479	68	UNDEFINED	-1	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	UNDEFINED	-1	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	UNDEFINED	-1	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	UNDEFINED	-1	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	UNDEFINED	-1	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		107780	8625	54	35S-GTPGammaS	-1	18	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		14	8625	54	35S-GTPGammaS	-1	18	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL15928	8625	54	35S-GTPGammaS	-1	18	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		124	9755	47	3H-5HT	-1	32	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-5HT	-1	32	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-5HT	-1	32	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-5HT	-1	32	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-5HT	-1	32	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		124	9755	47	3H-5HT	-1	32	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-5HT	-1	32	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-5HT	-1	32	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-5HT	-1	32	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-5HT	-1	32	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		24881753	143980	0	UNDEFINED	-14	2	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	666	16	4	4	9.1	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		CHEMBL374973	143980	0	UNDEFINED	-14	2	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	666	16	4	4	9.1	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		1884	9512	58	3H-GR-125743	3	5	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	None
		4440	9512	58	3H-GR-125743	3	5	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	None
		45	9512	58	3H-GR-125743	3	5	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	None
		CHEMBL1278	9512	58	3H-GR-125743	3	5	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	None
		DB00952	9512	58	3H-GR-125743	3	5	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	None
		24882268	179336	0	UNDEFINED	11	2	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	788	15	4	6	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL448555	179336	0	UNDEFINED	11	2	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	788	15	4	6	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		1809	6922	32	3H-5HT	-10	37	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-10	37	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-10	37	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		2543	10479	68	3H-5HT	1	32	Dog	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-5HT	1	32	Dog	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-5HT	1	32	Dog	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-5HT	1	32	Dog	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-5HT	1	32	Dog	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		107	6929	121	3H-GR-125743	-8	31	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-GR-125743	-8	31	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-GR-125743	-8	31	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		2543	10479	68	3H-Alniditan	-1	32	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-Alniditan	-1	32	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-Alniditan	-1	32	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-Alniditan	-1	32	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-Alniditan	-1	32	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		2865	10915	73	3H-5CT	-7	53	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-5CT	-7	53	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-5CT	-7	53	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-5CT	-7	53	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-5CT	-7	53	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		24881204	195201	0	UNDEFINED	-3	2	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	680	17	4	4	9.5	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		CHEMBL502138	195201	0	UNDEFINED	-3	2	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	680	17	4	4	9.5	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		5	6927	72	3H-5HT	-8	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-8	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-8	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-8	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	6927	72	3H-5HT	-15	53	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-15	53	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-15	53	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-15	53	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		11954224	222732	0	3H-5HT	-27	59	Dog	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		2543	10479	68	3H-GR-125743	-1	32	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-GR-125743	-1	32	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-GR-125743	-1	32	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-GR-125743	-1	32	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-GR-125743	-1	32	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		31101	7516	40	3H-5CT	-13	35	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	7516	40	3H-5CT	-13	35	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	7516	40	3H-5CT	-13	35	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	7516	40	3H-5CT	-13	35	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	7516	40	3H-5CT	-13	35	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		3294	8787	111	3H-5CT	-15	44	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	3H-5CT	-15	44	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	3H-5CT	-15	44	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	3H-5CT	-15	44	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	3H-5CT	-15	44	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		1621	9207	17	3H-5HT	-28	44	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	3H-5HT	-28	44	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	3H-5HT	-28	44	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	3H-5HT	-28	44	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	3H-5HT	-28	44	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		46780481	114308	20	3H-5CT	-50	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	3H-5CT	-50	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	3H-5CT	-50	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	3H-5CT	-50	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		31101	7516	40	3H-GR-125743	-13	35	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	7516	40	3H-GR-125743	-13	35	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	7516	40	3H-GR-125743	-13	35	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	7516	40	3H-GR-125743	-13	35	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	7516	40	3H-GR-125743	-13	35	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		134	9292	24	3H-5HT	-53	67	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-53	67	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-53	67	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-53	67	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-53	67	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2389	10104	118	3H-5HT	-208	66	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-5HT	-208	66	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-5HT	-208	66	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-5HT	-208	66	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-5HT	-208	66	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		155	7515	25	3H-5HT	-380	13	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		163	7515	25	3H-5HT	-380	13	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		62065	7515	25	3H-5HT	-380	13	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		CHEMBL6607	7515	25	3H-5HT	-380	13	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		DB01484	7515	25	3H-5HT	-380	13	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		41	8440	0	3H-GR-125743	-794	17	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		72036	8440	0	3H-GR-125743	-794	17	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		CHEMBL1765294	8440	0	3H-GR-125743	-794	17	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		1524	8962	96	3H-5HT	-2137	51	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-5HT	-2137	51	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-5HT	-2137	51	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-5HT	-2137	51	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-5HT	-2137	51	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-5HT	-2137	51	Bovine	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		173	10036	95	3H-5HT	-18	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	10036	95	3H-5HT	-18	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	10036	95	3H-5HT	-18	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		189	10265	39	3H-5HT	-416	17	Guinea pig	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		5163	10265	39	3H-5HT	-416	17	Guinea pig	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		CHEMBL297784	10265	39	3H-5HT	-416	17	Guinea pig	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		2470	10425	50	3H-5HT	-30199	58	Dog	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2470	10425	50	3H-5HT	-23988	58	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-30199	58	Dog	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-23988	58	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-30199	58	Dog	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-23988	58	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-30199	58	Dog	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-23988	58	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-30199	58	Dog	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-23988	58	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		24840389	121991	4	3H-GR-125743	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		CHEMBL334529	121991	4	3H-GR-125743	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		54841	209906	52	3H-5HT	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	209906	52	3H-5HT	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		None	224015	0	UNDEFINED	-1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	768	9	4	4	9.4	C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CC(C(F)(F)F)N5CCC(CC5)C6=CNC7=C6C=C(C=C7)NC(=O)C8=CC=C(C=C8)F	None
		None	224016	0	UNDEFINED	-1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	507	13	3	3	6.9	C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CCCCCCCCCC(=O)O	None
		None	224017	0	UNDEFINED	-1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	422	7	2	3	4.7	CN(C)CCCN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F	None
		None	224018	0	UNDEFINED	-1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	448	6	2	3	5.2	C1CCN(CC1)CCN2CCC(CC2)C3=CNC4=C3C=C(C=C4)NC(=O)C5=CC=C(C=C5)F	None
		None	224019	0	UNDEFINED	-1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	381	5	3	3	3.7	C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CCO	None
		None	224020	0	UNDEFINED	-1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	427	5	2	2	5.9	C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CC5=CC=CC=C5	None
		None	224021	0	UNDEFINED	-1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	449	10	2	2	7.1	CCCCCCCCN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F	None
		None	224022	0	UNDEFINED	-1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	743	10	5	5	7.3	C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CC(C(=O)N)N5CCC(CC5)C6=CNC7=C6C=C(C=C7)NC(=O)C8=CC=C(C=C8)F	None
		1192	6935	47	3H-5HT	-162	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		1794	6935	47	3H-5HT	-162	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		CHEMBL501701	6935	47	3H-5HT	-162	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		1028	7079	71	3H-5HT	-1862	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	7079	71	3H-5HT	-1862	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	7079	71	3H-5HT	-1862	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	7079	71	3H-5HT	-1862	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	7079	71	3H-5HT	-1862	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	7079	71	3H-5HT	-1862	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		179	7188	115	3H-5HT	-4365	50	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	7188	115	3H-5HT	-4365	50	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	7188	115	3H-5HT	-4365	50	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	7188	115	3H-5HT	-4365	50	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	7188	115	3H-5HT	-4365	50	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2477	7532	59	3H-5HT	-1479	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		2477	7532	59	3H-5HT	-1548	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		2477	7532	59	3H-5HT	-1548	29	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	7532	59	3H-5HT	-1479	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	7532	59	3H-5HT	-1548	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	7532	59	3H-5HT	-1548	29	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	7532	59	3H-5HT	-1479	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	7532	59	3H-5HT	-1548	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	7532	59	3H-5HT	-1548	29	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	7532	59	3H-5HT	-1479	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	7532	59	3H-5HT	-1548	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	7532	59	3H-5HT	-1548	29	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	7532	59	3H-5HT	-1479	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	7532	59	3H-5HT	-1548	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	7532	59	3H-5HT	-1548	29	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		2398	7741	62	3H-GR-125743	-1230	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	7741	62	3H-GR-125743	-1230	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	7741	62	3H-GR-125743	-1230	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	7741	62	3H-GR-125743	-1230	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	7741	62	3H-GR-125743	-1230	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		3151	8244	97	3H-5HT	-12882	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		945	8244	97	3H-5HT	-12882	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		965	8244	97	3H-5HT	-12882	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		CHEMBL219916	8244	97	3H-5HT	-12882	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		DB01184	8244	97	3H-5HT	-12882	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		681	8247	72	3H-5HT	-1995	38	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-5HT	-1995	38	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-5HT	-1995	38	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-5HT	-1995	38	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-5HT	-1995	38	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1353	8692	93	3H-5HT	-3890	85	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	8692	93	3H-Alniditan	-3890	85	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	8692	93	3H-5HT	-371	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-5HT	-3890	85	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-Alniditan	-3890	85	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-5HT	-371	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-5HT	-3890	85	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-Alniditan	-3890	85	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-5HT	-371	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-5HT	-3890	85	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-Alniditan	-3890	85	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-5HT	-371	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-5HT	-3890	85	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-Alniditan	-3890	85	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-5HT	-371	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		42	8844	57	3H-5HT	-1258	18	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		56971	8844	57	3H-5HT	-1258	18	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL8412	8844	57	3H-5HT	-1258	18	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		1524	8962	96	3H-5HT	-2137	51	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1524	8962	96	3H-5HT	-257	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1524	8962	96	3H-5HT	-7585	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-5HT	-2137	51	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-5HT	-257	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-5HT	-7585	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-5HT	-2137	51	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-5HT	-257	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-5HT	-7585	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-5HT	-2137	51	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-5HT	-257	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-5HT	-7585	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-5HT	-2137	51	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-5HT	-257	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-5HT	-7585	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-5HT	-2137	51	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-5HT	-257	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-5HT	-7585	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		1588	9105	27	3H-5-CT	-48	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	9105	27	3H-5-CT	-48	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	9105	27	3H-5-CT	-48	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	9105	27	3H-5-CT	-48	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	9105	27	3H-5-CT	-48	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		206	9271	16	3H-5HT	-3162	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	9271	16	3H-5HT	-3162	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	9271	16	3H-5HT	-3162	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		1782	9296	84	3H-5HT	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		241	9296	84	3H-5HT	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		4168	9296	84	3H-5HT	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		CHEMBL86	9296	84	3H-5HT	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		DB01233	9296	84	3H-5HT	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		127	9900	52	3H-5HT	-20417	15	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		688095	9900	52	3H-5HT	-20417	15	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL117405	9900	52	3H-5HT	-20417	15	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		2176	9901	68	3H-5HT	-1995	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		2176	9901	68	3H-8-OH-DPAT	-1995	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		2176	9901	68	3H-5HT	-30902	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	9901	68	3H-5HT	-1995	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	9901	68	3H-8-OH-DPAT	-1995	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	9901	68	3H-5HT	-30902	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	9901	68	3H-5HT	-1995	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	9901	68	3H-8-OH-DPAT	-1995	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	9901	68	3H-5HT	-30902	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	9901	68	3H-5HT	-1995	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	9901	68	3H-8-OH-DPAT	-1995	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	9901	68	3H-5HT	-30902	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	9901	68	3H-5HT	-1995	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	9901	68	3H-8-OH-DPAT	-1995	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	9901	68	3H-5HT	-30902	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		2181	9902	46	3H-5HT	-8317	34	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	9902	46	3H-5HT	-8317	34	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	9902	46	3H-5HT	-8317	34	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	9902	46	3H-5HT	-8317	34	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	9902	46	3H-5HT	-8317	34	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		2202	9906	96	3H-GR-125743	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		4850	9906	96	3H-GR-125743	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		49	9906	96	3H-GR-125743	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		CHEMBL1371770	9906	96	3H-GR-125743	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		DB12478	9906	96	3H-GR-125743	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		119570	9933	96	3H-GR-125743	-208	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	9933	96	3H-GR-125743	-208	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	9933	96	3H-GR-125743	-208	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	9933	96	3H-GR-125743	-208	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	9933	96	3H-GR-125743	-208	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		4209	9937	75	3H-5HT	-26915	33	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	3H-5HT	-26915	33	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	3H-5HT	-26915	33	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	3H-5HT	-26915	33	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	3H-5HT	-26915	33	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	3H-5HT	-26915	33	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		243	9976	91	3H-Alniditan	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3052762	9976	91	3H-Alniditan	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3502	9976	91	3H-Alniditan	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		CHEMBL117287	9976	91	3H-Alniditan	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		DB06480	9976	91	3H-Alniditan	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		2337	10030	77	3H-GR-125743	-89	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-GR-125743	-89	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-GR-125743	-89	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-GR-125743	-89	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-GR-125743	-89	62	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2	10035	23	3H-GR-125743	-2089	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	10035	23	3H-GR-125743	-2089	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	10035	23	3H-GR-125743	-2089	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		128563	10237	33	3H-5-CT	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		128563	10237	33	3H-GR-125743	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		1666	10237	33	3H-5-CT	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		1666	10237	33	3H-GR-125743	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		CHEMBL445332	10237	33	3H-5-CT	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		CHEMBL445332	10237	33	3H-GR-125743	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		DB12327	10237	33	3H-5-CT	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		DB12327	10237	33	3H-GR-125743	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		121881	10263	27	3H-5HT	-489778	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
		256	10263	27	3H-5HT	-489778	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
		CHEMBL68131	10263	27	3H-5HT	-489778	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
		2470	10425	50	3H-5HT	-186208	58	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2470	10425	50	3H-5HT	-23988	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-186208	58	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-23988	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-186208	58	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-23988	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-186208	58	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-23988	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-186208	58	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-23988	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		6917970	10463	61	3H-GR-125743	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	10463	61	3H-GR-125743	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	10463	61	3H-GR-125743	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		1267	10576	49	3H-5HT	-4168	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-5HT	-4168	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-5HT	-4168	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		108182	10903	22	3H-5HT	-32	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		245	10903	22	3H-5HT	-32	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		CHEMBL18041	10903	22	3H-5HT	-32	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
		2662	18156	131	3H-GR-125743	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	18156	131	3H-GR-125743	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		5090	22333	106	3H-GR-125743	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	22333	106	3H-GR-125743	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		671690	33870	35	3H-5HT	-10	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		671690	33870	35	3H-5HT	-10	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		671690	33870	35	3H-5HT	-10	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		CHEMBL1365455	33870	35	3H-5HT	-10	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		CHEMBL1365455	33870	35	3H-5HT	-10	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		CHEMBL1365455	33870	35	3H-5HT	-10	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		10297	33885	30	3H-GR-125743	-38	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	33885	30	3H-GR-125743	-38	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		127151	42104	18	3H-GR-125743	-1584	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	None
		3022645	42104	18	3H-GR-125743	-1584	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	None
		CHEMBL14370	42104	18	3H-GR-125743	-1584	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	None
		156391	53574	99	3H-GR-125743	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	53574	99	3H-GR-125743	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	53574	99	3H-GR-125743	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		108107	86719	38	3H-5HT	-15	16	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		156592250	86719	38	3H-5HT	-15	16	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL1256878	86719	38	3H-5HT	-15	16	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL212579	86719	38	3H-5HT	-15	16	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		442108	91411	6	3H-5-CT	-1	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
		CHEMBL222287	91411	6	3H-5-CT	-1	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
		2244	101008	100	3H-GR-125743	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		CHEMBL25	101008	100	3H-GR-125743	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		5280953	104137	109	3H-5HT	-12	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	None
		CHEMBL269538	104137	109	3H-5HT	-12	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	None
		127404	104360	22	3H-5HT	-72	4	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	7	2	4	2.2	CC(C)NCC(O)COc1ccccc1-n1cccc1	None
		CHEMBL27077	104360	22	3H-5HT	-72	4	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	7	2	4	2.2	CC(C)NCC(O)COc1ccccc1-n1cccc1	None
		104870	105656	47	3H-GR-125743	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	105656	47	3H-GR-125743	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	105656	47	3H-GR-125743	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		3663	106743	83	3H-GR-125743	-288	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		CHEMBL286494	106743	83	3H-GR-125743	-288	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		446220	140299	14	3H-GR-125743	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	140299	14	3H-GR-125743	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		44208932	147485	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		CHEMBL381689	147485	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		1615	174570	24	3H-GR-125743	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	174570	24	3H-GR-125743	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		5280343	195054	124	3H-GR-125743	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL1520590	195054	124	3H-GR-125743	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL50	195054	124	3H-GR-125743	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		3672	199312	136	3H-GR-125743	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		CHEMBL521	199312	136	3H-GR-125743	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		54676228	200394	112	3H-GR-125743	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		CHEMBL527	200394	112	3H-GR-125743	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		2771	201796	74	3H-5HT	-120	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		2771	201796	74	3H-GR-125743	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	201796	74	3H-5HT	-120	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	201796	74	3H-GR-125743	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	201796	74	3H-5HT	-120	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	201796	74	3H-GR-125743	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		4495	203314	92	3H-GR-125743	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	203314	92	3H-GR-125743	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		54677470	207330	115	3H-GR-125743	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	207330	115	3H-GR-125743	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	207330	115	3H-GR-125743	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		162265	209053	22	3H-GR-125743	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	209053	22	3H-GR-125743	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	209053	22	3H-GR-125743	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		5281600	209804	92	3H-5CT	-275	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5281600	209804	92	3H-GR-125743	-275	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	209804	92	3H-5CT	-275	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	209804	92	3H-GR-125743	-275	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5656	209845	87	3H-5HT	-79	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		5656	209845	87	3H-GR-125743	-79	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	209845	87	3H-5HT	-79	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	209845	87	3H-GR-125743	-79	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		3821	211497	17	3H-GR125743	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		CHEMBL742	211497	17	3H-GR125743	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		119607	212982	113	3H-GR-125743	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	212982	113	3H-GR-125743	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		16231	214288	57	3H-5HT	-7	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		CHEMBL945	214288	57	3H-5HT	-7	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		57174031	222719	0	3H-5HT	-1778	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
		57174031	222719	0	3H-5HT	-1778	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
		57174031	222719	0	3H-5HT	-1778	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
		None	222722	0	3H-5HT	-7943	11	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		165193	222724	0	3H-5HT	-22387	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	222724	0	3H-5HT	-22387	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	222724	0	3H-5HT	-22387	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		138107169	222731	0	3H-5HT	-1778	23	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		138107169	222731	0	3H-5HT	-707	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-5HT	-1778	23	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-5HT	-707	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		None	222772	0	3H-5-CT	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
		104911	222798	0	3H-GR-125743	-20892	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		None	222799	0	3H-8-OH-DPAT	-154	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	265	5	1	2	3.5	CCCN(CCC)C1CCC2=C(C=CC(=C2C1)O)F	None
		None	222914	0	3H-KETANSERIN	-10471	23	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		25137849	222958	0	3H-GR-125743	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	222958	0	3H-GR-125743	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		62857	222960	0	3H-5HT	-154	7	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	345	6	1	2	4.9	CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl	None
		None	223033	0	3H-5HT	-8317	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		None	223090	0	3H-GR-125743	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	223091	0	3H-GR-125743	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	223092	0	3H-GR-125743	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	223093	0	3H-GR-125743	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	223095	0	3H-GR-125743	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	223096	0	3H-GR-125743	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	223097	0	3H-GR-125743	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
		None	223104	0	3H-GR-125743	-13	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		1576	223105	0	3H-GR-125743	-16	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		None	223106	0	3H-GR-125743	-16	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
		4978	223107	0	3H-GR-125743	-7	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
		None	223108	0	3H-GR-125743	-3	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		None	223109	0	3H-GR-125743	-281	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		None	223110	0	3H-GR-125743	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
		None	223121	0	3H-GR-125743	-1862	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	246	2	1	4	1.6	CCCN1CCCC2C1CC3=CN=C(N=C3C2)N	None
		135269	223168	0	3H-GR-125743	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	223169	0	3H-GR-125743	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		5018304	223170	0	3H-GR-125743	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
		84003	223171	0	3H-GR-125743	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
		123619	223172	0	3H-GR-125743	-1412	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
		119828	223173	0	3H-GR-125743	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	223268	0	3H-GR-125743	-4570	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		213	10625	55	3H-GR-125743	-2	43	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	10625	55	3H-GR-125743	-2	43	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	10625	55	3H-GR-125743	-2	43	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	10625	55	3H-GR-125743	-2	43	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	10625	55	3H-GR-125743	-2	43	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		135398745	9688	112	3H-5CT	-147	65	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-5CT	-147	65	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-5CT	-147	65	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-5CT	-147	65	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		24881264	195086	0	UNDEFINED	-13	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	709	19	4	4	10.3	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		CHEMBL500488	195086	0	UNDEFINED	-13	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	709	19	4	4	10.3	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		133	9274	52	3H-5HT	-3	43	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	3H-5HT	-3	43	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	3H-5HT	-3	43	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	3H-5HT	-3	43	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	3H-5HT	-3	43	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		42	8844	57	3H-5HT	-229	18	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		56971	8844	57	3H-5HT	-229	18	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL8412	8844	57	3H-5HT	-229	18	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		173	10036	95	3H-5HT	-18	23	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	10036	95	3H-5HT	-18	23	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	10036	95	3H-5HT	-18	23	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		1524	8962	96	3H-GR-125743	-257	51	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-GR-125743	-257	51	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-GR-125743	-257	51	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-GR-125743	-257	51	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-GR-125743	-257	51	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-GR-125743	-257	51	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		115	10563	80	3H-5HT	-2	27	Dog	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-2	27	Dog	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-2	27	Dog	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		115	10563	80	3H-5HT	-2	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-2	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-2	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		1220	6975	55	3H-5HT	-891	44	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-891	44	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-891	44	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-891	44	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		115237	62359	119	3H-Alniditan	-501	54	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-Alniditan	-501	54	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		1342	6824	49	3H-5HT	-3	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	6824	49	3H-5HT	-3	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	6824	49	3H-5HT	-3	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		107780	8625	54	3H-GR-125743	-1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		14	8625	54	3H-GR-125743	-1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL15928	8625	54	3H-GR-125743	-1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		1621	9207	17	3H-LSD	-40	44	Dog	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	3H-LSD	-40	44	Dog	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	3H-LSD	-40	44	Dog	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	3H-LSD	-40	44	Dog	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	3H-LSD	-40	44	Dog	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28	10269	46	35S-GTPGammaS	-13	10	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		3292447	10269	46	35S-GTPGammaS	-13	10	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL20963	10269	46	35S-GTPGammaS	-13	10	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		122	8219	9	3H-5HT	-4	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		156314	8219	9	3H-5HT	-4	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL1332062	8219	9	3H-5HT	-4	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		122	8219	9	3H-5HT	-15	11	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		156314	8219	9	3H-5HT	-15	11	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL1332062	8219	9	3H-5HT	-15	11	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		134	9292	24	3H-5HT	-9	67	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-9	67	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-9	67	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-9	67	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-9	67	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		277	8083	62	3H-5HT	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	3H-5HT	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	3H-5HT	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	3H-5HT	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	3H-5HT	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		7153	104796	77	3H-5HT	-30	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	104796	77	3H-5HT	-30	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		25058166	222739	0	3H-GR-125743	-616	26	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-GR-125743	-616	26	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		11957541	8241	40	3H-5HT	-281	16	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		1229	8241	40	3H-5HT	-281	16	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		147	8241	40	3H-5HT	-281	16	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		170617	8241	40	3H-5HT	-281	16	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		CHEMBL6616	8241	40	3H-5HT	-281	16	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
		132	8058	13	3H-5HT	-3715	15	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		155346	8058	13	3H-5HT	-3715	15	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		CHEMBL378501	8058	13	3H-5HT	-3715	15	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		2543	10479	68	3H-5HT	-11	32	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-5HT	-11	32	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-5HT	-11	32	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-5HT	-11	32	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-5HT	-11	32	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1220	6975	55	3H-5HT	-891	44	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		1220	6975	55	3H-5HT	-95	44	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-891	44	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-95	44	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-891	44	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-95	44	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-891	44	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-95	44	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		173	10036	95	3H-5HT	-14	23	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	10036	95	3H-5HT	-14	23	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	10036	95	3H-5HT	-14	23	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		3337	213146	27	3H-GR-125743	-60	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	3H-GR-125743	-60	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	3H-GR-125743	-60	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	3H-GR-125743	-60	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	3H-GR-125743	-60	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		127404	104360	22	3H-5HT	-72	4	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	274	7	2	4	2.2	CC(C)NCC(O)COc1ccccc1-n1cccc1	None
		CHEMBL27077	104360	22	3H-5HT	-72	4	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	274	7	2	4	2.2	CC(C)NCC(O)COc1ccccc1-n1cccc1	None
		24882266	195066	0	UNDEFINED	2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	812	17	4	4	11.6	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL500230	195066	0	UNDEFINED	2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	812	17	4	4	11.6	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		24882267	195106	0	UNDEFINED	776	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	840	19	4	4	12.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL500749	195106	0	UNDEFINED	776	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	840	19	4	4	12.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		24881619	195817	0	UNDEFINED	9	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	826	18	4	4	12.0	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL509314	195817	0	UNDEFINED	9	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	826	18	4	4	12.0	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		2105	9828	37	3H-GR-125743	-4	32	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	9828	37	3H-GR-125743	-4	32	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	9828	37	3H-GR-125743	-4	32	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	9828	37	3H-GR-125743	-4	32	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	9828	37	3H-GR-125743	-4	32	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		135398737	7745	93	3H-5CT	-99	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-5CT	-99	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-5CT	-99	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-5CT	-99	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-5CT	-99	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		277	8083	62	3H-5HT	-208	50	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	3H-5HT	-208	50	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	3H-5HT	-208	50	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	3H-5HT	-208	50	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	3H-5HT	-208	50	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		7153	104796	77	3H-5HT	-30	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	104796	77	3H-5HT	-30	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		165193	222724	0	3H-5HT	-5495	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	222724	0	3H-5HT	-5495	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	222724	0	3H-5HT	-5495	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		179	7188	115	3H-5CT	-38	50	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	7188	115	3H-5CT	-38	50	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	7188	115	3H-5CT	-38	50	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	7188	115	3H-5CT	-38	50	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	7188	115	3H-5CT	-38	50	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		151	9194	44	UNDEFINED	-151	4	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	None
		20	9194	44	UNDEFINED	-151	4	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	None
		5311258	9194	44	UNDEFINED	-151	4	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	None
		CHEMBL101690	9194	44	UNDEFINED	-151	4	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.4	CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F	None
		173	10036	95	3H-5HT	-14	23	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	10036	95	3H-5HT	-14	23	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	10036	95	3H-5HT	-14	23	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		2402	10143	62	3H-GR-125743	-5	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	10143	62	3H-GR-125743	-5	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	10143	62	3H-GR-125743	-5	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	10143	62	3H-GR-125743	-5	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	10143	62	3H-GR-125743	-5	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		1621	9207	17	3H-5HT	-25	44	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	3H-5HT	-25	44	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	3H-5HT	-25	44	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	3H-5HT	-25	44	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	3H-5HT	-25	44	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1342	6824	49	3H-5HT	-6	19	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	6824	49	3H-5HT	-6	19	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	6824	49	3H-5HT	-6	19	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		1342	6824	49	3H-5HT	-6	19	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	6824	49	3H-5HT	-6	19	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	6824	49	3H-5HT	-6	19	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		2389	10104	118	3H-Alniditan	-72	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-Alniditan	-72	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-Alniditan	-72	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-Alniditan	-72	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-Alniditan	-72	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		7153	104796	77	3H-5HT	-77	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	104796	77	3H-5HT	-77	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		132	8058	13	3H-5HT	-3715	15	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		155346	8058	13	3H-5HT	-3715	15	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		CHEMBL378501	8058	13	3H-5HT	-3715	15	Bovine	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		155	7515	25	3H-5HT	-380	13	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		163	7515	25	3H-5HT	-380	13	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		62065	7515	25	3H-5HT	-380	13	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		CHEMBL6607	7515	25	3H-5HT	-380	13	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		DB01484	7515	25	3H-5HT	-380	13	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		1342	6824	49	3H-5HT	-6	19	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	6824	49	3H-5HT	-6	19	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	6824	49	3H-5HT	-6	19	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3294	8787	111	3H-5CT	-15	44	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	3H-5CT	-15	44	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	3H-5CT	-15	44	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	3H-5CT	-15	44	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	3H-5CT	-15	44	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		115237	62359	119	3H-GR-125743	-107	54	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-GR-125743	-107	54	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		5	6927	72	3H-LSD	-20	53	Dog	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-LSD	-20	53	Dog	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-LSD	-20	53	Dog	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-LSD	-20	53	Dog	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		138107169	222731	0	3H-5HT	-707	23	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-5HT	-707	23	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		135398745	9688	112	3H-5CT	-147	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-5CT	-147	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-5CT	-147	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-5CT	-147	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		115	10563	80	3H-5HT	-9	27	Bovine	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-9	27	Bovine	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-9	27	Bovine	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		42	8844	57	3H-5HT	-229	18	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		56971	8844	57	3H-5HT	-229	18	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL8412	8844	57	3H-5HT	-229	18	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		24881687	179593	0	UNDEFINED	3	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	776	10	4	4	10.2	O=C(Nc1ccc2[nH]cc(C3CCN(Cc4cccc(CN5CCC(c6c[nH]c7ccc(NC(=O)c8ccc(F)cc8)cc67)CC5)c4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL451394	179593	0	UNDEFINED	3	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	776	10	4	4	10.2	O=C(Nc1ccc2[nH]cc(C3CCN(Cc4cccc(CN5CCC(c6c[nH]c7ccc(NC(=O)c8ccc(F)cc8)cc67)CC5)c4)CC3)c2c1)c1ccc(F)cc1	None
		7153	104796	77	3H-5HT	-77	33	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	104796	77	3H-5HT	-77	33	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		5475158	73987	25	3H-5HT	-380	14	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		CHEMBL18786	73987	25	3H-5HT	-380	14	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		135398745	9688	112	3H-GR-125743	-147	65	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-GR-125743	-147	65	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-GR-125743	-147	65	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-GR-125743	-147	65	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		7153	104796	77	UNDEFINED	-83	33	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	104796	77	UNDEFINED	-83	33	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		2435	10362	83	3H-5CT	-52	48	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	3H-5CT	-52	48	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	3H-5CT	-52	48	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	3H-5CT	-52	48	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	3H-5CT	-52	48	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		2601	10552	33	3H-GR-125743	-14	21	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	10552	33	3H-GR-125743	-14	21	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	10552	33	3H-GR-125743	-14	21	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	10552	33	3H-GR-125743	-14	21	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	10552	33	3H-GR-125743	-14	21	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		None	222725	0	3H-5HT	-16	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		102	10899	48	3H-5HT	-102	49	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-102	49	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-102	49	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-102	49	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-102	49	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		135398737	7745	93	3H-5HT	-426	90	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-5HT	-426	90	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-5HT	-426	90	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-5HT	-426	90	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-5HT	-426	90	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		None	222993	0	3H-5HT	-144	14	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	438	5	1	4	4.8	C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45	None
		119570	9933	96	3H-GR-125743	-208	39	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	9933	96	3H-GR-125743	-208	39	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	9933	96	3H-GR-125743	-208	39	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	9933	96	3H-GR-125743	-208	39	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	9933	96	3H-GR-125743	-208	39	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		5475158	73987	25	3H-5HT	-380	14	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		CHEMBL18786	73987	25	3H-5HT	-380	14	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		4106	9280	22	3H-5HT	-44	33	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-5HT	-44	33	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-5HT	-44	33	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-5HT	-44	33	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		2543	10479	68	3H-5HT	-11	32	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-5HT	-11	32	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-5HT	-11	32	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-5HT	-11	32	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-5HT	-11	32	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		4106	9280	22	3H-5HT	-44	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-5HT	-44	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-5HT	-44	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-5HT	-44	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		115237	62359	119	3H-Alniditan	-107	54	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-Alniditan	-107	54	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		1574	6869	60	3H-5HT	-12	21	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	6869	60	3H-5HT	-12	21	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	6869	60	3H-5HT	-12	21	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		206	9271	16	3H-5HT	-3162	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	9271	16	3H-5HT	-3162	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	9271	16	3H-5HT	-3162	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		103	10925	61	3H-GR-125743	-19	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-GR-125743	-19	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-GR-125743	-19	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-GR-125743	-19	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-GR-125743	-19	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		242	7258	124	3H-5CT	-41	51	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-5CT	-41	51	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-5CT	-41	51	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-5CT	-41	51	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-5CT	-41	51	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		5	6927	72	3H-5HT	-8	53	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-8	53	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-8	53	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-8	53	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		46780481	114308	20	3H-5HT	-107	53	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	3H-5HT	-107	53	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	3H-5HT	-107	53	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	3H-5HT	-107	53	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		None	222725	0	3H-5HT	-16	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		155	7515	25	3H-5HT	-776	13	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		163	7515	25	3H-5HT	-776	13	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		62065	7515	25	3H-5HT	-776	13	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		CHEMBL6607	7515	25	3H-5HT	-776	13	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		DB01484	7515	25	3H-5HT	-776	13	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		15897	9637	0	3H-GR-125743	-46	36	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	9637	0	3H-GR-125743	-46	36	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	9637	0	3H-GR-125743	-46	36	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		115237	62359	119	3H-5CT	-107	54	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-5CT	-107	54	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		None	222717	0	3H-5HT	-338	21	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		102	10899	48	35S-GTPGammaS	-102	49	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	35S-GTPGammaS	-102	49	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	35S-GTPGammaS	-102	49	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	35S-GTPGammaS	-102	49	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	35S-GTPGammaS	-102	49	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		141	8209	35	3H-5HT	-1	22	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6089	8209	35	3H-5HT	-1	22	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		CHEMBL12420	8209	35	3H-5HT	-1	22	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		DB01488	8209	35	3H-5HT	-1	22	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		5	6927	72	3H-5HT	-6	53	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-6	53	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-6	53	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-6	53	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	6927	72	3H-5HT	-6	53	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	6927	72	3H-5HT	-8	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-6	53	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-8	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-6	53	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-8	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-6	53	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-8	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107780	8625	54	3H-GR-125743	-1	18	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		14	8625	54	3H-GR-125743	-1	18	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL15928	8625	54	3H-GR-125743	-1	18	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		71299720	222730	0	3H-5HT	-1	17	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		5	6927	72	3H-5HT	-15	53	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-15	53	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-15	53	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-15	53	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	6929	121	3H-5HT	-8	31	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-8	31	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-8	31	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		107	6929	121	3H-5HT	-8	31	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-8	31	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-8	31	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		24881754	195071	0	UNDEFINED	-3	2	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	694	18	4	4	9.9	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		CHEMBL500284	195071	0	UNDEFINED	-3	2	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	694	18	4	4	9.9	CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		107	6929	121	3H-5HT	-33	31	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-33	31	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-33	31	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1809	6922	32	3H-5HT	-16	37	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	6922	32	3H-5HT	-10	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1809	6922	32	3H-GR-125743	-10	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-16	37	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-10	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-GR-125743	-10	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-16	37	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-10	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-GR-125743	-10	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		107	6929	121	3H-5HT	-33	31	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-33	31	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-33	31	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		2865	10915	73	3H-5CT	-7	53	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-5CT	-7	53	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-5CT	-7	53	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-5CT	-7	53	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-5CT	-7	53	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		1809	6922	32	3H-5HT	-16	37	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-16	37	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-16	37	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		5	6927	72	3H-5HT	-8	53	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-8	53	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-8	53	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-8	53	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	6929	121	3H-5HT	-4	31	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-4	31	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-4	31	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		5	6927	72	3H-5HT	-8	53	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-8	53	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-8	53	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-8	53	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107780	8625	54	35S-GTPGammaS	-1	18	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		14	8625	54	35S-GTPGammaS	-1	18	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL15928	8625	54	35S-GTPGammaS	-1	18	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		71299720	222730	0	3H-5HT	-1	17	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		71299720	222730	0	3H-5HT	-1	17	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		71299720	222730	0	3H-5HT	-1	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		2435	10362	83	3H-5CT	-52	48	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	3H-5CT	-52	48	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	3H-5CT	-52	48	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	3H-5CT	-52	48	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	3H-5CT	-52	48	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		None	222717	0	3H-5HT	-338	21	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		138107169	222731	0	3H-5HT	-1778	23	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-5HT	-1778	23	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		None	223057	0	3H-5CT	-223	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	6	0	6	3.4	C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54	None
		10257	7525	31	3H-5HT	-3	19	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		144	7525	31	3H-5HT	-3	19	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		CHEMBL416526	7525	31	3H-5HT	-3	19	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		DB01445	7525	31	3H-5HT	-3	19	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		1220	6975	55	3H-5HT	-891	44	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-891	44	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-891	44	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-891	44	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		1524	8962	96	3H-5HT	-2137	51	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-5HT	-2137	51	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-5HT	-2137	51	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-5HT	-2137	51	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-5HT	-2137	51	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-5HT	-2137	51	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		None	222738	0	3H-5HT	-3235	6	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	358	4	0	3	2.8	CCCS(=O)(=O)N(C)C1CCN2CCC3=CC=CC=C3C2C1.Cl	None
		4595	183494	106	3H-Serotonin	-22	14	Rat	4.7	pKi	=	4.7	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		CHEMBL46	183494	106	3H-Serotonin	-22	14	Rat	4.7	pKi	=	4.7	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		173	10036	95	3H-5HT	-14	23	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	10036	95	3H-5HT	-14	23	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	10036	95	3H-5HT	-14	23	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		102	10899	48	3H-5HT	-102	49	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-102	49	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-102	49	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-102	49	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-102	49	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		None	222725	0	3H-5HT	-16	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		115	10563	80	3H-5HT	-2	27	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-2	27	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-2	27	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		7153	104796	77	3H-5HT	-30	33	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	104796	77	3H-5HT	-30	33	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		10624	77075	19	3H-GR-125743	-165	32	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	77075	19	3H-GR-125743	-165	32	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	77075	19	3H-GR-125743	-165	32	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		135398737	7745	93	3H-GR-125743	-99	90	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-GR-125743	-99	90	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-GR-125743	-99	90	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-GR-125743	-99	90	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-GR-125743	-99	90	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		24881552	195890	0	UNDEFINED	45	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	700	9	4	4	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL510280	195890	0	UNDEFINED	45	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	700	9	4	4	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		None	222725	0	3H-5HT	-16	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		None	222717	0	3H-5HT	-338	21	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		138107169	222731	0	3H-5HT	-1778	23	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-5HT	-1778	23	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		135	9310	43	3H-5HT	-43	56	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-5HT	-43	56	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-5HT	-43	56	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-5HT	-43	56	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-5HT	-43	56	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		115	10563	80	3H-5HT	-4	27	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-4	27	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-4	27	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		None	222725	0	3H-5HT	-16	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		1621	9207	17	3H-5HT	-42	44	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	3H-5HT	-42	44	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	3H-5HT	-42	44	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	3H-5HT	-42	44	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	3H-5HT	-42	44	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		None	224014	0	UNDEFINED	4	2	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	726	10	4	4	9.0	C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CC=CCN5CCC(CC5)C6=CNC7=C6C=C(C=C7)NC(=O)C8=CC=C(C=C8)F	None
		104911	222798	0	3H-8-OH-DPAT	-20892	37	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		134	9292	24	3H-5HT	-13	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-13	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-13	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-13	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-13	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		None	222725	0	3H-5HT	-28	24	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		28	10269	46	35S-GTPGammaS	-13	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		3292447	10269	46	35S-GTPGammaS	-13	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL20963	10269	46	35S-GTPGammaS	-13	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		102	10899	48	3H-GR-125743	-102	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-GR-125743	-102	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-GR-125743	-102	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-GR-125743	-102	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-GR-125743	-102	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		258	10340	31	3H-5HT	-501	8	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	300	7	1	5	2.4	CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		5191	10340	31	3H-5HT	-501	8	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	300	7	1	5	2.4	CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		CHEMBL287045	10340	31	3H-5HT	-501	8	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	300	7	1	5	2.4	CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		None	223101	0	3H-5HT	-83	6	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	390	4	1	4	3.2	C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)C(F)(F)F	None
		2220	9908	82	3H-5HT	-851	14	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		27400	9908	82	3H-5HT	-851	14	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		93	9908	82	3H-5HT	-851	14	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		CHEMBL294951	9908	82	3H-5HT	-851	14	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		DB06153	9908	82	3H-5HT	-851	14	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		15897	9637	0	3H-GR-125743	-46	36	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	9637	0	3H-GR-125743	-46	36	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	9637	0	3H-GR-125743	-46	36	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		134	9292	24	3H-5HT	-13	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-13	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-13	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-13	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-13	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1220	6975	55	3H-5HT	-95	44	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-95	44	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-95	44	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-95	44	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		4106	9280	22	3H-5HT	-323	33	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-5HT	-323	33	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-5HT	-323	33	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-5HT	-323	33	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		102	10899	48	3H-5HT	-102	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-102	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-102	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-102	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-102	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		141	8209	35	3H-5HT	-1	22	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6089	8209	35	3H-5HT	-1	22	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		CHEMBL12420	8209	35	3H-5HT	-1	22	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		DB01488	8209	35	3H-5HT	-1	22	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		115	10563	80	3H-5HT	-9	27	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-9	27	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-9	27	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		2220	9908	82	3H-5HT	-851	14	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		27400	9908	82	3H-5HT	-851	14	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		93	9908	82	3H-5HT	-851	14	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		CHEMBL294951	9908	82	3H-5HT	-851	14	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		DB06153	9908	82	3H-5HT	-851	14	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		145	6928	49	3H-5HT	-9	30	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	6928	49	3H-5HT	-9	30	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	6928	49	3H-5HT	-9	30	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	6928	49	3H-5HT	-9	30	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1621	9207	17	3H-5HT	-42	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	3H-5HT	-42	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	3H-5HT	-42	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	3H-5HT	-42	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	3H-5HT	-42	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		115	10563	80	3H-5HT	-9	27	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-9	27	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-9	27	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		206	9271	16	3H-5HT	-645	25	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	9271	16	3H-5HT	-645	25	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	9271	16	3H-5HT	-645	25	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		115	10563	80	3H-5HT	-9	27	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-9	27	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-9	27	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		102	10899	48	3H-5HT	-102	49	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-102	49	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-102	49	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-102	49	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-102	49	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		2543	10479	68	3H-5HT	-11	32	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-5HT	-11	32	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-5HT	-11	32	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-5HT	-11	32	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-5HT	-11	32	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		2389	10104	118	3H-GR-125743	-72	66	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-GR-125743	-72	66	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-GR-125743	-72	66	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-GR-125743	-72	66	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-GR-125743	-72	66	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		4452	9538	19	3H-5CT	-9999	18	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		983	9538	19	3H-5CT	-9999	18	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		CHEMBL20734	9538	19	3H-5CT	-9999	18	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		1150	10650	121	3H-5HT	-3	25	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	10650	121	3H-5HT	-3	25	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	10650	121	3H-5HT	-3	25	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	10650	121	3H-5HT	-3	25	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		5	6927	72	3H-5HT	-15	53	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-15	53	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-15	53	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-15	53	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	6927	72	35S-GTPGammaS	-6	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	35S-GTPGammaS	-6	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	35S-GTPGammaS	-6	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	35S-GTPGammaS	-6	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		2543	10479	68	3H-5HT	-1	32	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-5HT	-1	32	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-5HT	-1	32	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-5HT	-1	32	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-5HT	-1	32	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5	6927	72	3H-GR-125743	-6	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-GR-125743	-6	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-GR-125743	-6	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-GR-125743	-6	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		24881201	193628	0	UNDEFINED	4	2	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	526	6	4	4	5.2	CN1CCC(c2c[nH]c3ccc(NC(=O)CC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		CHEMBL489453	193628	0	UNDEFINED	4	2	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	526	6	4	4	5.2	CN1CCC(c2c[nH]c3ccc(NC(=O)CC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1	None
		5	6927	72	3H-5HT	-15	53	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-15	53	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-15	53	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-15	53	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		134	9292	24	3H-5HT	-13	67	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-13	67	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-13	67	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-13	67	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-13	67	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2543	10479	68	3H-5HT	-1	32	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-5HT	-1	32	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-5HT	-1	32	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-5HT	-1	32	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-5HT	-1	32	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		10257	7525	31	3H-5HT	-3	19	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		144	7525	31	3H-5HT	-3	19	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		CHEMBL416526	7525	31	3H-5HT	-3	19	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		DB01445	7525	31	3H-5HT	-3	19	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		2543	10479	68	3H-5HT	-1	32	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-5HT	-1	32	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-5HT	-1	32	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-5HT	-1	32	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-5HT	-1	32	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		134	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		5	6927	72	3H-5HT	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		2389	10104	118	3H-5CT	-72	66	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-5CT	-72	66	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-5CT	-72	66	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-5CT	-72	66	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-5CT	-72	66	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		24881686	195168	0	UNDEFINED	8	2	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	832	18	4	7	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL501645	195168	0	UNDEFINED	8	2	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	832	18	4	7	8.5	O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		5	6927	72	35S-GTPGammaS	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	35S-GTPGammaS	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	35S-GTPGammaS	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	35S-GTPGammaS	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	6929	121	3H-5HT	-4	31	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-4	31	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-4	31	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		134	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		135	9310	43	3H-5HT	-15	56	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-5HT	-15	56	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-5HT	-15	56	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-5HT	-15	56	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-5HT	-15	56	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		135	9310	43	3H-5HT	-15	56	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-5HT	-15	56	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-5HT	-15	56	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-5HT	-15	56	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-5HT	-15	56	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		107	6929	121	3H-5HT	-20	31	Dog	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-20	31	Dog	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-20	31	Dog	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1588	9105	27	3H-5HT	-91	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	9105	27	3H-5HT	-91	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	9105	27	3H-5HT	-91	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	9105	27	3H-5HT	-91	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	9105	27	3H-5HT	-91	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		102	10899	48	3H-5HT	-77	49	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-77	49	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-77	49	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-77	49	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-77	49	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		1220	6975	55	3H-5HT	-95	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-95	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-95	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-95	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		202	8290	77	3H-5HT	-1	33	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	8290	77	3H-5HT	-1	33	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	8290	77	3H-5HT	-1	33	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	8290	77	3H-5HT	-1	33	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	8290	77	3H-5HT	-1	33	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		2470	10425	50	3H-5HT	-23988	58	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-23988	58	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-23988	58	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-23988	58	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-23988	58	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		None	223018	0	3H-GR-125743	-30199	29	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		102	10899	48	3H-5HT	-77	49	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-77	49	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-77	49	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-77	49	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-77	49	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		1588	9105	27	3H-5HT	-91	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	9105	27	3H-5HT	-91	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	9105	27	3H-5HT	-91	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	9105	27	3H-5HT	-91	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	9105	27	3H-5HT	-91	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		16362	9899	71	3H-5CT	-691	29	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	3H-5CT	-691	29	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	3H-5CT	-691	29	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	3H-5CT	-691	29	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	3H-5CT	-691	29	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2470	10425	50	3H-5HT	-23988	58	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-23988	58	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-23988	58	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-23988	58	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-23988	58	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1353	8692	93	3H-5HT	-3890	85	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-5HT	-3890	85	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-5HT	-3890	85	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-5HT	-3890	85	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-5HT	-3890	85	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3036864	209533	19	3H-5HT	-14791	27	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-5HT	-14791	27	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-5HT	-14791	27	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-5HT	-14791	27	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		165193	222724	0	3H-5HT	-22387	30	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	222724	0	3H-5HT	-22387	30	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	222724	0	3H-5HT	-22387	30	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		71299720	222730	0	3H-5HT	-25	17	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		102	10899	48	3H-5HT	-81	49	Dog	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-81	49	Dog	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-81	49	Dog	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-81	49	Dog	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-81	49	Dog	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		71299720	222730	0	3H-5HT	-25	17	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		1524	8962	96	3H-5HT	-2137	51	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-5HT	-2137	51	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-5HT	-2137	51	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-5HT	-2137	51	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-5HT	-2137	51	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-5HT	-2137	51	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		165193	222724	0	3H-5HT	-22387	30	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	222724	0	3H-5HT	-22387	30	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	222724	0	3H-5HT	-22387	30	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		None	223018	0	3H-GR-125743	-30199	29	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		1809	6922	32	3H-5HT	-91	37	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-91	37	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-91	37	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		206	9271	16	3H-5HT	-645	25	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	9271	16	3H-5HT	-645	25	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	9271	16	3H-5HT	-645	25	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		1353	8692	93	3H-5HT	-3890	85	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-5HT	-3890	85	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-5HT	-3890	85	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-5HT	-3890	85	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-5HT	-3890	85	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1212	8443	50	3H-GR-125743	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-GR-125743	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-GR-125743	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-GR-125743	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-GR-125743	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		107	6929	121	3H-5HT	-8	31	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-8	31	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-8	31	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		None	222735	0	3H-5HT	-4	6	Dog	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.9	CCC(=O)C1=CC=C(C=C1)N	None
		155	7515	25	3H-5HT	-776	13	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		163	7515	25	3H-5HT	-776	13	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		62065	7515	25	3H-5HT	-776	13	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		CHEMBL6607	7515	25	3H-5HT	-776	13	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		DB01484	7515	25	3H-5HT	-776	13	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
		15387	52596	55	3H-5CT	-19	24	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	52596	55	3H-5CT	-19	24	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		141	8209	35	3H-5HT	-1	22	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6089	8209	35	3H-5HT	-1	22	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		CHEMBL12420	8209	35	3H-5HT	-1	22	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		DB01488	8209	35	3H-5HT	-1	22	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		1150	10650	121	3H-5HT	-15	25	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	10650	121	3H-5HT	-15	25	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	10650	121	3H-5HT	-15	25	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	10650	121	3H-5HT	-15	25	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		1613	9127	53	3H-GR-125743	-38	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	3H-GR-125743	-38	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	3H-GR-125743	-38	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	3H-GR-125743	-38	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	3H-GR-125743	-38	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		132	8058	13	3H-5HT	-1023	15	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		155346	8058	13	3H-5HT	-1023	15	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		CHEMBL378501	8058	13	3H-5HT	-1023	15	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		4106	9280	22	3H-5HT	-323	33	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-5HT	-323	33	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-5HT	-323	33	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-5HT	-323	33	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		1150	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		132	8058	13	3H-5HT	-1023	15	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		155346	8058	13	3H-5HT	-1023	15	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		CHEMBL378501	8058	13	3H-5HT	-1023	15	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		5074	10105	80	3H-5HT	-323	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	10105	80	3H-5HT	-323	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	10105	80	3H-5HT	-323	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	10105	80	3H-5HT	-323	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		7153	104796	77	3H-5HT	-30	33	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	104796	77	3H-5HT	-30	33	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		44668	222721	0	3H-5HT	-1	4	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	228	3	2	1	3.1	C1CNCCC1CCC2=CNC3=CC=CC=C32	None
		165193	222724	0	3H-5HT	-19498	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	222724	0	3H-5HT	-19498	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	222724	0	3H-5HT	-19498	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		3012003	222924	0	3H-5HT	-147	12	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
		173	10036	95	3H-5HT	-18	23	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	10036	95	3H-5HT	-18	23	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	10036	95	3H-5HT	-18	23	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		None	222738	0	3H-5HT	-3235	6	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	358	4	0	3	2.8	CCCS(=O)(=O)N(C)C1CCN2CCC3=CC=CC=C3C2C1.Cl	None
		11831220	199337	8	UNDEFINED	8	2	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	2	2.6	CN1CCC(c2c[nH]c3ccc(N)cc23)CC1	None
		CHEMBL521235	199337	8	UNDEFINED	8	2	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	2	2.6	CN1CCC(c2c[nH]c3ccc(N)cc23)CC1	None
		1150	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		3025067	106158	64	3H-5HT	-19	15	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		65853	106158	64	3H-5HT	-19	15	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		CHEMBL282614	106158	64	3H-5HT	-19	15	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		1574	6869	60	3H-5HT	-4	21	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	6869	60	3H-5HT	-4	21	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	6869	60	3H-5HT	-4	21	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		5	6927	72	3H-5HT	-15	53	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-15	53	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-15	53	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-15	53	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		135	9310	43	3H-5HT	-223	56	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		135	9310	43	3H-5HT	-43	56	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-5HT	-223	56	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-5HT	-43	56	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-5HT	-223	56	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-5HT	-43	56	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-5HT	-223	56	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-5HT	-43	56	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-5HT	-223	56	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-5HT	-43	56	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		182585	22219	15	3H-5HT	-1	4	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	386	7	1	5	2.9	O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2O1	None
		CHEMBL12152	22219	15	3H-5HT	-1	4	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	386	7	1	5	2.9	O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2O1	None
		152662	222736	0	3H-5HT	-109	7	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	276	5	3	3	2.6	CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)O	None
		3036864	209533	19	3H-5HT	-14791	27	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-5HT	-14791	27	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-5HT	-14791	27	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-5HT	-14791	27	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		5	6927	72	3H-5HT	-15	53	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-15	53	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-15	53	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-15	53	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		107	6929	121	3H-5HT	-4	31	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-4	31	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-4	31	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		134	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-9	67	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		133	9274	52	3H-5HT	-2	43	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	3H-5HT	-2	43	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	3H-5HT	-2	43	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	3H-5HT	-2	43	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	3H-5HT	-2	43	Bovine	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		5	6927	72	3H-5HT	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-6	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		4595	183494	106	None	-22	14	Rat	8.3	pKi	=	8.3	Binding	The binding affinity was measured on 5-hydroxytryptamine 1D receptor using [3H]- serotonin as radioligand.The binding affinity was measured on 5-hydroxytryptamine 1D receptor using [3H]- serotonin as radioligand.	Drug Central	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		CHEMBL46	183494	106	None	-22	14	Rat	8.3	pKi	=	8.3	Binding	The binding affinity was measured on 5-hydroxytryptamine 1D receptor using [3H]- serotonin as radioligand.The binding affinity was measured on 5-hydroxytryptamine 1D receptor using [3H]- serotonin as radioligand.	Drug Central	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		107	6929	121	3H-5HT	-8	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-8	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-8	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		71299720	222730	0	3H-5HT	-3	17	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		71299720	222730	0	3H-5HT	-3	17	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		1353	8692	93	3H-5CT	-371	85	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-5CT	-371	85	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-5CT	-371	85	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-5CT	-371	85	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-5CT	-371	85	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1150	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	10650	121	3H-5HT	-3	25	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		138107169	222731	0	3H-5HT	-707	23	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-5HT	-707	23	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		2220	9908	82	3H-5HT	-851	14	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		27400	9908	82	3H-5HT	-851	14	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		93	9908	82	3H-5HT	-851	14	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		CHEMBL294951	9908	82	3H-5HT	-851	14	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		DB06153	9908	82	3H-5HT	-851	14	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
		134	9292	24	3H-5HT	-53	67	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-53	67	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-53	67	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-53	67	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-53	67	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1150	10650	121	3H-5HT	-3	25	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	10650	121	3H-5HT	-3	25	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	10650	121	3H-5HT	-3	25	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	10650	121	3H-5HT	-3	25	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		122	8219	9	3H-5HT	-4	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		156314	8219	9	3H-5HT	-4	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL1332062	8219	9	3H-5HT	-4	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		1209	8439	75	3H-5HT	-794	32	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	8439	75	3H-5HT	-794	32	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	8439	75	3H-5HT	-794	32	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	8439	75	3H-5HT	-794	32	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	8439	75	3H-5HT	-794	32	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		135	9310	43	3H-5HT	-223	56	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-5HT	-223	56	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-5HT	-223	56	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-5HT	-223	56	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-5HT	-223	56	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		152662	222736	0	3H-5HT	-109	7	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	276	5	3	3	2.6	CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)O	None
		None	222725	0	3H-5HT	-16	24	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		None	222725	0	3H-5HT	-28	24	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		2726	7706	68	3H-GR-125743	-31	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-GR-125743	-31	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-GR-125743	-31	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-GR-125743	-31	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-GR-125743	-31	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1150	10650	121	3H-5HT	-3	25	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	10650	121	3H-5HT	-3	25	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	10650	121	3H-5HT	-3	25	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	10650	121	3H-5HT	-3	25	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		None	222725	0	3H-5HT	-33	24	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		15897	9637	0	3H-GR-125743	-46	36	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	9637	0	3H-GR-125743	-46	36	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	9637	0	3H-GR-125743	-46	36	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		1220	6975	55	3H-GR-125743	-95	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-GR-125743	-95	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-GR-125743	-95	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-GR-125743	-95	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		None	222725	0	3H-5HT	-33	24	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		102	10899	48	3H-5HT	-102	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-102	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-102	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-102	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-102	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		None	222725	0	3H-5HT	-28	24	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		135398737	7745	93	3H-5CT	-99	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-5CT	-99	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-5CT	-99	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-5CT	-99	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-5CT	-99	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135409468	8816	69	3H-GR-125743	-169	39	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	8816	69	3H-GR-125743	-169	39	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	8816	69	3H-GR-125743	-169	39	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		1809	6922	32	3H-5HT	-91	37	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		4	6922	32	3H-5HT	-91	37	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL18840	6922	32	3H-5HT	-91	37	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
		103	10925	61	3H-5CT	-19	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-5CT	-19	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-5CT	-19	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-5CT	-19	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-5CT	-19	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		135	9310	43	3H-5HT	-223	56	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-5HT	-223	56	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-5HT	-223	56	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-5HT	-223	56	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-5HT	-223	56	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		None	223158	0	3H-5CT	-537	11	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	243	3	1	4	2.7	CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N	None
		42	8844	57	3H-5HT	-1258	18	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		56971	8844	57	3H-5HT	-1258	18	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL8412	8844	57	3H-5HT	-1258	18	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		43815	193699	64	3H-5HT	-977	25	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	193699	64	3H-5HT	-977	25	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	193699	64	3H-5HT	-977	25	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		2176	9901	68	3H-5HT	-1995	27	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	9901	68	3H-5HT	-1995	27	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	9901	68	3H-5HT	-1995	27	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	9901	68	3H-5HT	-1995	27	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	9901	68	3H-5HT	-1995	27	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		5	6927	72	3H-5HT	-20	53	Dog	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-20	53	Dog	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-20	53	Dog	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-20	53	Dog	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		2865	10915	73	3H-Alniditan	-7	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-Alniditan	-7	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-Alniditan	-7	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-Alniditan	-7	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-Alniditan	-7	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		5029	22317	92	None	13	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	359	8	1	5	3.0	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C	None
		CHEMBL1219	22317	92	None	13	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	359	8	1	5	3.0	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C	None
		145	6928	49	3H-5HT	1	30	Dog	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	6928	49	3H-5HT	1	30	Dog	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	6928	49	3H-5HT	1	30	Dog	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	6928	49	3H-5HT	1	30	Dog	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		2176	9901	68	None	-1995	27	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	9901	68	None	-1995	27	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	9901	68	None	-1995	27	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	9901	68	None	-1995	27	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	9901	68	None	-1995	27	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		138107169	222731	0	3H-5HT	-14	23	Dog	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-5HT	-14	23	Dog	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		2303	9961	68	None	-11	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		4946	9961	68	None	-11	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		564	9961	68	None	-11	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		63	9961	68	None	-11	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		91536	9961	68	None	-11	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL27	9961	68	None	-11	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL452861	9961	68	None	-11	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		DB00571	9961	68	None	-11	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		33630	185736	99	None	-24	28	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL47050	185736	99	None	-24	28	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		1613	9127	53	None	-38	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	None	-38	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	None	-38	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	None	-38	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	None	-38	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		15387	52596	55	None	-19	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	52596	55	None	-19	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		16362	9899	71	None	-691	29	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	None	-691	29	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	None	-691	29	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	None	-691	29	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	None	-691	29	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2337	10030	77	None	-89	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	None	-89	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	None	-89	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	None	-89	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	None	-89	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		4106	9280	22	3H-5HT	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-5HT	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-5HT	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-5HT	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		4106	9280	22	3H-5HT	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-5HT	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-5HT	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-5HT	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		2402	10143	62	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	10143	62	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	10143	62	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	10143	62	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	10143	62	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		277	8083	62	None	-208	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	None	-208	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	None	-208	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	None	-208	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	None	-208	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		66265	100788	15	None	-1	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL248702	100788	15	None	-1	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		4106	9280	22	3H-GR-125743	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-GR-125743	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-GR-125743	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-GR-125743	-44	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		4106	9280	22	3H-5HT	-323	33	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-5HT	-323	33	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-5HT	-323	33	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-5HT	-323	33	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		None	222725	0	3H-5HT	-28	24	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		1222	8445	49	3H-Alniditan	-512	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	8445	49	3H-Alniditan	-512	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	8445	49	3H-Alniditan	-512	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	8445	49	3H-Alniditan	-512	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	8445	49	3H-Alniditan	-512	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1353	8692	93	3H-Alniditan	-371	85	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-Alniditan	-371	85	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-Alniditan	-371	85	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-Alniditan	-371	85	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-Alniditan	-371	85	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2337	10030	77	3H-Alniditan	-89	62	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-Alniditan	-89	62	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-Alniditan	-89	62	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-Alniditan	-89	62	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-Alniditan	-89	62	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2470	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		None	223229	0	UNDEFINED	-33	28	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		2470	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		138107169	222731	0	3H-5HT	-1778	23	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-5HT	-1778	23	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		102	10899	48	3H-5HT	-102	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-102	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-102	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-102	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-102	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		2470	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		115	10563	80	3H-5HT	-4	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-4	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-4	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		1150	10650	121	3H-5HT	-3	25	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	10650	121	3H-5HT	-3	25	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	10650	121	3H-5HT	-3	25	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	10650	121	3H-5HT	-3	25	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		3337	213146	27	3H-GR-125743	-60	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	3H-GR-125743	-60	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	3H-GR-125743	-60	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	3H-GR-125743	-60	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	3H-GR-125743	-60	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		130	10273	47	35S-GTPGammaS	-120	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		3378093	10273	47	35S-GTPGammaS	-120	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		CHEMBL281350	10273	47	35S-GTPGammaS	-120	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
		2470	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-186208	58	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		138107169	222731	0	3H-5HT	-1778	23	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-5HT	-1778	23	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		135398745	9688	112	3H-Alniditan	-147	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-Alniditan	-147	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-Alniditan	-147	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-Alniditan	-147	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		165193	222724	0	3H-5HT	-19498	30	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	222724	0	3H-5HT	-19498	30	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	222724	0	3H-5HT	-19498	30	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		2337	10030	77	3H-5CT	-89	62	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-5CT	-89	62	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-5CT	-89	62	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-5CT	-89	62	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-5CT	-89	62	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		4106	9280	22	3H-5HT	-323	33	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-5HT	-323	33	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-5HT	-323	33	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-5HT	-323	33	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		122	8219	9	3H-5HT	-15	11	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		156314	8219	9	3H-5HT	-15	11	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL1332062	8219	9	3H-5HT	-15	11	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		18971832	9196	0	3H-5HT	-97	13	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		21	9196	0	3H-5HT	-97	13	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		CHEMBL3186179	9196	0	3H-5HT	-97	13	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		100	10577	58	3H-GR-125743	-28	54	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-GR-125743	-28	54	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-GR-125743	-28	54	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-GR-125743	-28	54	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-GR-125743	-28	54	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		115	10563	80	3H-5HT	-4	27	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-4	27	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-4	27	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		102	10899	48	3H-5HT	-102	49	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-102	49	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-102	49	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-102	49	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-102	49	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		135398737	7745	93	3H-Alniditan	-99	90	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-Alniditan	-99	90	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-Alniditan	-99	90	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-Alniditan	-99	90	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-Alniditan	-99	90	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		206	9271	16	3H-5HT	-3162	25	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	9271	16	3H-5HT	-3162	25	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	9271	16	3H-5HT	-3162	25	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		127	9900	52	3H-5HT	-14791	15	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		688095	9900	52	3H-5HT	-14791	15	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL117405	9900	52	3H-5HT	-14791	15	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		115	10563	80	3H-5HT	-4	27	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-4	27	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-4	27	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		102	10899	48	3H-5HT	-177	49	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		102	10899	48	3H-5HT	-102	49	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-177	49	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-102	49	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-177	49	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-102	49	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-177	49	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-102	49	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-177	49	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-102	49	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		None	222737	0	3H-5HT	-3715	19	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		1222	8445	49	None	-512	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	8445	49	None	-512	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	8445	49	None	-512	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	8445	49	None	-512	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	8445	49	None	-512	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2470	10425	50	None	-23988	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	None	-23988	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	None	-23988	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	None	-23988	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	None	-23988	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		11954224	222732	0	3H-5CT	-28	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		135398745	9688	112	None	-147	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	None	-147	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	None	-147	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	None	-147	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		107	6929	121	3H-5HT	-8	31	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-8	31	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-8	31	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		212	10578	47	None	-5	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		2639	10578	47	None	-5	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		941651	10578	47	None	-5	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		CHEMBL1201	10578	47	None	-5	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		DB01623	10578	47	None	-5	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		1342	6824	49	3H-5HT	-3	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	6824	49	3H-5HT	-3	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	6824	49	3H-5HT	-3	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		100	10577	58	None	-28	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	None	-28	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	None	-28	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	None	-28	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	None	-28	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		145	6928	49	3H-5-CT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	6928	49	3H-5-CT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	6928	49	3H-5-CT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	6928	49	3H-5-CT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		107	6929	121	3H-LSD	-20	31	Dog	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-LSD	-20	31	Dog	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-LSD	-20	31	Dog	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1621	9207	17	3H-5HT	-42	44	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	3H-5HT	-42	44	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	3H-5HT	-42	44	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	3H-5HT	-42	44	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	3H-5HT	-42	44	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		3652	10869	79	3H-5HT	2	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	10869	79	3H-5HT	2	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	10869	79	3H-5HT	2	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	10869	79	3H-5HT	2	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	10869	79	3H-5HT	2	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		2726	7706	68	None	-31	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	None	-31	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	None	-31	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	None	-31	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	None	-31	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398737	7745	93	None	-99	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-99	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-99	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-99	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-99	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		5	6927	72	3H-5HT	-6	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-6	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-6	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-6	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		1212	8443	50	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3389	224490	0	None	-1	26	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
		2351	10059	64	None	4	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		2820	10059	64	None	4	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		5035	10059	64	None	4	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		CHEMBL81	10059	64	None	4	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		DB00481	10059	64	None	4	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		1353	8692	93	None	-371	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	None	-371	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	None	-371	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	None	-371	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	None	-371	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2181	9902	46	None	-74	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	9902	46	None	-74	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	9902	46	None	-74	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	9902	46	None	-74	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	9902	46	None	-74	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		2389	10104	118	3H-5CT	-72	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-5CT	-72	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-5CT	-72	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-5CT	-72	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-5CT	-72	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		213	10625	55	None	-2	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	10625	55	None	-2	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	10625	55	None	-2	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	10625	55	None	-2	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	10625	55	None	-2	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		135	9310	43	None	-43	56	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	None	-43	56	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	None	-43	56	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	None	-43	56	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	None	-43	56	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2389	10104	118	3H-Alniditan	-208	66	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-Alniditan	-208	66	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-Alniditan	-208	66	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-Alniditan	-208	66	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-Alniditan	-208	66	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2470	10425	50	3H-5HT	-1862	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-1862	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-1862	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-1862	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-1862	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		54477	91428	36	3H-5HT	-85	22	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		CHEMBL22242	91428	36	3H-5HT	-85	22	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		2470	10425	50	3H-5HT	-1862	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-5HT	-1862	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-5HT	-1862	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-5HT	-1862	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-5HT	-1862	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		7153	104796	77	3H-5HT	-30	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	104796	77	3H-5HT	-30	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		2337	10030	77	3H-5HT	-691	62	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-5HT	-691	62	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-5HT	-691	62	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-5HT	-691	62	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-5HT	-691	62	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		242	7258	124	3H-GR-125743	-41	51	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-GR-125743	-41	51	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-GR-125743	-41	51	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-GR-125743	-41	51	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-GR-125743	-41	51	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		122	8219	9	3H-5HT	-15	11	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		156314	8219	9	3H-5HT	-15	11	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL1332062	8219	9	3H-5HT	-15	11	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		103	10925	61	3H-Alniditan	-19	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-Alniditan	-19	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-Alniditan	-19	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-Alniditan	-19	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-Alniditan	-19	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		None	222725	0	3H-LSD	-44	24	Dog	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
		122	8219	9	3H-5HT	-15	11	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		156314	8219	9	3H-5HT	-15	11	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		CHEMBL1332062	8219	9	3H-5HT	-15	11	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
		219050	10146	25	3H-GR-125743	-436	21	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		52	10146	25	3H-GR-125743	-436	21	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		CHEMBL431367	10146	25	3H-GR-125743	-436	21	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		None	223229	0	UNDEFINED	-41	28	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		2176	9901	68	3H-5HT	-19952	27	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	9901	68	3H-5HT	-19952	27	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	9901	68	3H-5HT	-19952	27	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	9901	68	3H-5HT	-19952	27	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	9901	68	3H-5HT	-19952	27	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		115	10563	80	3H-5HT	-9	27	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-9	27	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-9	27	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		206	9271	16	3H-5HT	-4265	25	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	9271	16	3H-5HT	-4265	25	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	9271	16	3H-5HT	-4265	25	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		127	9900	52	3H-5HT	-14791	15	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		688095	9900	52	3H-5HT	-14791	15	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL117405	9900	52	3H-5HT	-14791	15	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		3337	213146	27	3H-GR-125743	-60	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	3H-GR-125743	-60	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	3H-GR-125743	-60	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	3H-GR-125743	-60	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	3H-GR-125743	-60	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		115	10563	80	3H-5HT	-2	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-2	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-2	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		2181	9902	46	3H-Alniditan	-74	34	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	9902	46	3H-Alniditan	-74	34	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	9902	46	3H-Alniditan	-74	34	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	9902	46	3H-Alniditan	-74	34	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	9902	46	3H-Alniditan	-74	34	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		152662	222736	0	3H-5HT	-169	7	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	276	5	3	3	2.6	CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)O	None
		None	222737	0	3H-5HT	-4073	19	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		206	9271	16	3H-5HT	-4265	25	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	9271	16	3H-5HT	-4265	25	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	9271	16	3H-5HT	-4265	25	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		11954259	222758	0	3H-GR-125743	-2187	43	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		18922713	105274	0	3H-5HT	-870	9	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	None
		CHEMBL276031	105274	0	3H-5HT	-870	9	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	None
		115	10563	80	3H-5HT	-9	27	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-9	27	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-9	27	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		277	8083	62	3H-5CT	-208	50	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	3H-5CT	-208	50	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	3H-5CT	-208	50	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	3H-5CT	-208	50	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	3H-5CT	-208	50	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		None	222750	0	3H-5HT	-1621	15	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
		115	10563	80	3H-5HT	-9	27	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-9	27	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-9	27	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		5475158	73987	25	3H-5HT	-1584	14	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		CHEMBL18786	73987	25	3H-5HT	-1584	14	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		242	7258	124	3H-GR-125743	-41	51	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-GR-125743	-41	51	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-GR-125743	-41	51	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-GR-125743	-41	51	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-GR-125743	-41	51	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		134	9292	24	3H-GR-125743	-13	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		134	9292	24	3H-GR125743	-13	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-GR-125743	-13	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-GR125743	-13	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-GR-125743	-13	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-GR125743	-13	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-GR-125743	-13	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-GR125743	-13	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-GR-125743	-13	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-GR125743	-13	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1353	8692	93	3H-5HT	-3890	85	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-5HT	-3890	85	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-5HT	-3890	85	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-5HT	-3890	85	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-5HT	-3890	85	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1621	9207	17	3H-5HT	-42	44	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	3H-5HT	-42	44	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	3H-5HT	-42	44	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	3H-5HT	-42	44	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	3H-5HT	-42	44	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		242	7258	124	None	-41	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	None	-41	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	None	-41	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	None	-41	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	None	-41	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		2435	10362	83	None	-52	48	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	None	-52	48	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	None	-52	48	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	None	-52	48	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	None	-52	48	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		49831411	224525	0	None	-1	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	659	19	0	6	8.7	CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12	None
		10257	7525	31	3H-5HT	-3	19	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		144	7525	31	3H-5HT	-3	19	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		CHEMBL416526	7525	31	3H-5HT	-3	19	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		DB01445	7525	31	3H-5HT	-3	19	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		4806	10780	88	None	-1	13	Human	8.1	pKi	=	8.1	Binding	Mechanism of ActionMechanism of Action	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		7351	10780	88	None	-1	13	Human	8.1	pKi	=	8.1	Binding	Mechanism of ActionMechanism of Action	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		9966051	10780	88	None	-1	13	Human	8.1	pKi	=	8.1	Binding	Mechanism of ActionMechanism of Action	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		CHEMBL2104993	10780	88	None	-1	13	Human	8.1	pKi	=	8.1	Binding	Mechanism of ActionMechanism of Action	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		DB09068	10780	88	None	-1	13	Human	8.1	pKi	=	8.1	Binding	Mechanism of ActionMechanism of Action	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		107	6929	121	3H-5HT	-8	31	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-8	31	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-8	31	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		46780481	114308	20	3H-Alniditan	-50	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	3H-Alniditan	-50	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	3H-Alniditan	-50	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	3H-Alniditan	-50	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		1342	6824	49	3H-5HT	-3	19	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		3	6824	49	3H-5HT	-3	19	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		CHEMBL277120	6824	49	3H-5HT	-3	19	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
		123606	7140	70	None	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	None
		128	7140	70	None	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	None
		7110	7140	70	None	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	None
		CHEMBL1505	7140	70	None	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	None
		DB00918	7140	70	None	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	None
		None	222735	0	3H-5HT	4	6	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.9	CCC(=O)C1=CC=C(C=C1)N	None
		2389	10104	118	None	-72	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	None	-72	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	None	-72	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	None	-72	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	None	-72	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		102	10899	48	None	-102	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	None	-102	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	None	-102	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	None	-102	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	None	-102	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		1621	9207	17	3H-5HT	-28	44	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	3H-5HT	-28	44	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	3H-5HT	-28	44	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	3H-5HT	-28	44	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	3H-5HT	-28	44	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2543	10479	68	3H-5HT	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-5HT	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-5HT	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-5HT	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-5HT	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		115237	62359	119	None	-107	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	None	-107	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		134	9292	24	3H-5HT	-6	67	Dog	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-6	67	Dog	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-6	67	Dog	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-6	67	Dog	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-6	67	Dog	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2601	10552	33	None	-14	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	10552	33	None	-14	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	10552	33	None	-14	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	10552	33	None	-14	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	10552	33	None	-14	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		6971132	222788	0	3H-5-CT	-1	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	268	1	2	2	2.1	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)O	None
		3294	8787	111	None	-15	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	None	-15	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	None	-15	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	None	-15	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	None	-15	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		2105	9828	37	None	-4	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	9828	37	None	-4	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	9828	37	None	-4	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	9828	37	None	-4	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	9828	37	None	-4	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		2393	10107	82	None	1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	None
		5078	10107	82	None	1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	None
		51	10107	82	None	1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	None
		CHEMBL905	10107	82	None	1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	None
		DB00953	10107	82	None	1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	None
		10257	7525	31	3H-5HT	-3	19	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		144	7525	31	3H-5HT	-3	19	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		CHEMBL416526	7525	31	3H-5HT	-3	19	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		DB01445	7525	31	3H-5HT	-3	19	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
		2543	10479	68	3H-LSD	1	32	Dog	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-LSD	1	32	Dog	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-LSD	1	32	Dog	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-LSD	1	32	Dog	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-LSD	1	32	Dog	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		107	6929	121	3H-5HT	-33	31	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-33	31	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-33	31	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1220	6975	55	3H-5HT	-891	44	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-891	44	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-891	44	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-891	44	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		127	9900	52	3H-5HT	-14791	15	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		688095	9900	52	3H-5HT	-14791	15	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL117405	9900	52	3H-5HT	-14791	15	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		141	8209	35	3H-5HT	-1	22	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6089	8209	35	3H-5HT	-1	22	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		CHEMBL12420	8209	35	3H-5HT	-1	22	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		DB01488	8209	35	3H-5HT	-1	22	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		135398737	7745	93	3H-Alniditan	-426	90	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-Alniditan	-426	90	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-Alniditan	-426	90	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-Alniditan	-426	90	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-Alniditan	-426	90	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		42	8844	57	3H-5HT	-1258	18	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		56971	8844	57	3H-5HT	-1258	18	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL8412	8844	57	3H-5HT	-1258	18	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		107	6929	121	3H-5HT	-33	31	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		1833	6929	121	3H-5HT	-33	31	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		CHEMBL8165	6929	121	3H-5HT	-33	31	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
		5074	10105	80	3H-GR-125743	-323	30	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	10105	80	3H-GR-125743	-323	30	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	10105	80	3H-GR-125743	-323	30	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	10105	80	3H-GR-125743	-323	30	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		165193	222724	0	3H-5HT	-22387	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	222724	0	3H-5HT	-22387	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	222724	0	3H-5HT	-22387	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		102	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		102	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		138107169	222731	0	3H-5HT	-707	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-5HT	-707	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		1353	8692	93	3H-GR-125743	-371	85	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-GR-125743	-371	85	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-GR-125743	-371	85	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-GR-125743	-371	85	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-GR-125743	-371	85	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		145	6928	49	3H-5HT	-9	30	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	6928	49	3H-5HT	-9	30	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	6928	49	3H-5HT	-9	30	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	6928	49	3H-5HT	-9	30	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		127	9900	52	3H-5HT	-20417	15	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		688095	9900	52	3H-5HT	-20417	15	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL117405	9900	52	3H-5HT	-20417	15	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
		102	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-5HT	-177	49	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		24882192	195581	0	UNDEFINED	125	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	714	10	4	4	8.9	O=C(Nc1ccc2[nH]cc(C3CCN(CCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		CHEMBL505954	195581	0	UNDEFINED	125	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	714	10	4	4	8.9	O=C(Nc1ccc2[nH]cc(C3CCN(CCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	None
		None	222750	0	3H-8-OH-DPAT	-1621	15	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
		31101	7516	40	None	-13	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	7516	40	None	-13	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	7516	40	None	-13	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	7516	40	None	-13	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	7516	40	None	-13	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		37	7565	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		460	7565	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		54746	7565	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		CHEMBL1201087	7565	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		DB00248	7565	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		3652	10869	79	None	2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	10869	79	None	2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	10869	79	None	2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	10869	79	None	2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	10869	79	None	2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		1251	8473	30	None	1	3	Human	8.1	pKi	=	8.1	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	Drug Central	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	None
		7191	8473	30	None	1	3	Human	8.1	pKi	=	8.1	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	Drug Central	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	None
		77992	8473	30	None	1	3	Human	8.1	pKi	=	8.1	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	Drug Central	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	None
		CHEMBL1279	8473	30	None	1	3	Human	8.1	pKi	=	8.1	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	Drug Central	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	None
		DB00998	8473	30	None	1	3	Human	8.1	pKi	=	8.1	Binding	In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor	Drug Central	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	None
		46780481	114308	20	None	-50	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	None	-50	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	None	-50	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	None	-50	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		2543	10479	68	3H-GR-125743	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-GR-125743	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-GR-125743	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-GR-125743	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-GR-125743	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1621	9207	17	None	-25	44	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	None	-25	44	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	None	-25	44	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	None	-25	44	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	None	-25	44	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligandBinding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2865	10915	73	None	-7	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	None	-7	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	None	-7	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	None	-7	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	None	-7	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		None	223120	0	3H-GR-125743	-11	19	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	451	8	2	4	3.2	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C	None
		134	9292	24	3H-5HT	-9	67	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-9	67	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-9	67	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-9	67	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-9	67	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		134	9292	24	None	-13	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	None	-13	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	None	-13	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	None	-13	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	None	-13	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2869	10924	89	None	-2	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		60	10924	89	None	-2	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		60857	10924	89	None	-2	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		CHEMBL1185	10924	89	None	-2	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		DB00315	10924	89	None	-2	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		5	6927	72	3H-5HT	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	6927	72	3H-5HT	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-5HT	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-5HT	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-5HT	-6	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		2543	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	None	-1	32	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		103	10925	61	3H-5CT	-19	53	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-5CT	-19	53	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-5CT	-19	53	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-5CT	-19	53	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-5CT	-19	53	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398745	9688	112	3H-5HT	-407	65	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-5HT	-407	65	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-5HT	-407	65	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-5HT	-407	65	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		173	10036	95	3H-5HT	-14	23	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	10036	95	3H-5HT	-14	23	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	10036	95	3H-5HT	-14	23	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		1220	6975	55	3H-5HT	-407	44	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-407	44	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-407	44	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-407	44	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		1353	8692	93	3H-5HT	-3890	85	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-5HT	-3890	85	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-5HT	-3890	85	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-5HT	-3890	85	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-5HT	-3890	85	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1220	6975	55	3H-5HT	-95	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-95	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-95	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-95	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		132	8058	13	3H-5HT	-2344	15	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		155346	8058	13	3H-5HT	-2344	15	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		CHEMBL378501	8058	13	3H-5HT	-2344	15	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		115	10563	80	3H-5HT	-2	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		4296	10563	80	3H-5HT	-2	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		CHEMBL274866	10563	80	3H-5HT	-2	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
		1150	10650	121	3H-5HT	-3	25	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	10650	121	3H-5HT	-3	25	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	10650	121	3H-5HT	-3	25	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	10650	121	3H-5HT	-3	25	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		132	8058	13	3H-5HT	-2344	15	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		155346	8058	13	3H-5HT	-2344	15	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		CHEMBL378501	8058	13	3H-5HT	-2344	15	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
		1150	10650	121	3H-5HT	-3	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		125	10650	121	3H-5HT	-3	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		CHEMBL6640	10650	121	3H-5HT	-3	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		DB08653	10650	121	3H-5HT	-3	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
		1574	6869	60	3H-5HT	-12	21	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	6869	60	3H-5HT	-12	21	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	6869	60	3H-5HT	-12	21	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		1220	6975	55	3H-5HT	-407	44	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-407	44	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-407	44	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-407	44	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		21830793	98610	10	3H-8-OH-DPAT	-588	46	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	98610	10	3H-8-OH-DPAT	-588	46	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		1220	6975	55	3H-5HT	-891	44	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-891	44	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-891	44	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-891	44	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		1588	9105	27	None	-48	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	9105	27	None	-48	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	9105	27	None	-48	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	9105	27	None	-48	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	9105	27	None	-48	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2865	10915	73	3H-GR-125743	-7	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-GR-125743	-7	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-GR-125743	-7	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-GR-125743	-7	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-GR-125743	-7	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		11954224	222732	0	None	-28	59	Human	8.0	pKi	=	8.0	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		3658	10879	53	None	4	8	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		517	10879	53	None	4	8	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		5709	10879	53	None	4	8	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		CHEMBL312448	10879	53	None	4	8	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		DB06694	10879	53	None	4	8	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		133	9274	52	None	-3	43	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	None	-3	43	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	None	-3	43	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	None	-3	43	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	None	-3	43	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		103	10925	61	None	-19	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	None	-19	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	None	-19	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	None	-19	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	None	-19	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		124	9755	47	None	-1	32	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	None	-1	32	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	None	-1	32	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	None	-1	32	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	None	-1	32	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4209	9937	75	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		2543	10479	68	3H-5HT	-2	32	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-5HT	-2	32	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-5HT	-2	32	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-5HT	-2	32	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-5HT	-2	32	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		2543	10479	68	3H-5HT	-2	32	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		5358	10479	68	3H-5HT	-2	32	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		54	10479	68	3H-5HT	-2	32	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL128	10479	68	3H-5HT	-2	32	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB00669	10479	68	3H-5HT	-2	32	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		10531	8202	21	None	-4	24	Human	8.0	pKi	=	8	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		121	8202	21	None	-4	24	Human	8.0	pKi	=	8	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		888	8202	21	None	-4	24	Human	8.0	pKi	=	8	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		CHEMBL1732	8202	21	None	-4	24	Human	8.0	pKi	=	8	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		DB00320	8202	21	None	-4	24	Human	8.0	pKi	=	8	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		1782	9296	84	3H-5HT	-602	23	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		241	9296	84	3H-5HT	-602	23	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		4168	9296	84	3H-5HT	-602	23	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		CHEMBL86	9296	84	3H-5HT	-602	23	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		DB01233	9296	84	3H-5HT	-602	23	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		206	9271	16	3H-5HT	-645	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		68848	9271	16	3H-5HT	-645	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		CHEMBL12314	9271	16	3H-5HT	-645	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
		141	8209	35	3H-5-CT	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6089	8209	35	3H-5-CT	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		CHEMBL12420	8209	35	3H-5-CT	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		DB01488	8209	35	3H-5-CT	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		134	9292	24	3H-5HT	-13	67	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-5HT	-13	67	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-5HT	-13	67	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-5HT	-13	67	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-5HT	-13	67	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2477	7532	59	3H-5HT	-1479	29	Bovine	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	7532	59	3H-5HT	-1479	29	Bovine	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	7532	59	3H-5HT	-1479	29	Bovine	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	7532	59	3H-5HT	-1479	29	Bovine	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	7532	59	3H-5HT	-1479	29	Bovine	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		2176	9901	68	3H-5HT	-30902	27	Rat	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		4828	9901	68	3H-5HT	-30902	27	Rat	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		91	9901	68	3H-5HT	-30902	27	Rat	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		CHEMBL500	9901	68	3H-5HT	-30902	27	Rat	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		DB00960	9901	68	3H-5HT	-30902	27	Rat	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
		1220	6975	55	3H-5HT	-407	44	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-407	44	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-407	44	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-407	44	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		2435	10362	83	3H-Alniditan	-52	48	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	3H-Alniditan	-52	48	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	3H-Alniditan	-52	48	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	3H-Alniditan	-52	48	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	3H-Alniditan	-52	48	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		135398737	7745	93	3H-5HT	-426	90	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-5HT	-426	90	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-5HT	-426	90	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-5HT	-426	90	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-5HT	-426	90	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1220	6975	55	3H-5HT	-407	44	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-5HT	-407	44	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-5HT	-407	44	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-5HT	-407	44	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		242	7258	124	None	-41	51	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	12784105
		34	7258	124	None	-41	51	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	12784105
		60795	7258	124	None	-41	51	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	12784105
		CHEMBL1112	7258	124	None	-41	51	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	12784105
		DB01238	7258	124	None	-41	51	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	12784105
		2389	10104	118	None	-72	66	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8935801
		2389	10104	118	None	-72	66	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8967979
		5073	10104	118	None	-72	66	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8935801
		5073	10104	118	None	-72	66	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8967979
		96	10104	118	None	-72	66	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8935801
		96	10104	118	None	-72	66	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8967979
		CHEMBL85	10104	118	None	-72	66	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8935801
		CHEMBL85	10104	118	None	-72	66	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8967979
		DB00734	10104	118	None	-72	66	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8935801
		DB00734	10104	118	None	-72	66	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8967979
		10	7510	28	None	1	9	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
		3654103	7510	28	None	1	9	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
		CHEMBL534232	7510	28	None	1	9	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
		2393	10107	82	None	1	5	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10193663
		5078	10107	82	None	1	5	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10193663
		51	10107	82	None	1	5	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10193663
		CHEMBL905	10107	82	None	1	5	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10193663
		DB00953	10107	82	None	1	5	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10193663
		2543	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10193663
		2543	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10611634
		2543	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	1565658
		2543	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	1652050
		2543	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8967979
		5358	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10193663
		5358	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10611634
		5358	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	1565658
		5358	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	1652050
		5358	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8967979
		54	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10193663
		54	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10611634
		54	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	1565658
		54	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	1652050
		54	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8967979
		CHEMBL128	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10193663
		CHEMBL128	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10611634
		CHEMBL128	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	1565658
		CHEMBL128	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	1652050
		CHEMBL128	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8967979
		DB00669	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10193663
		DB00669	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10611634
		DB00669	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	1565658
		DB00669	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	1652050
		DB00669	10479	68	None	-1	32	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8967979
		10446	7318	0	None	4	4	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	458	9	2	7	1.8	COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)CS(=O)(=O)NC	9050026
		133081	7318	0	None	4	4	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	458	9	2	7	1.8	COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)CS(=O)(=O)NC	9050026
		CHEMBL2110755	7318	0	None	4	4	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	458	9	2	7	1.8	COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)CS(=O)(=O)NC	9050026
		1251	8473	30	None	1	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	9986723
		7191	8473	30	None	1	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	9986723
		77992	8473	30	None	1	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	9986723
		CHEMBL1279	8473	30	None	1	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	9986723
		DB00998	8473	30	None	1	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	2	4	2	2.1	CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O	9986723
		1884	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10193663
		1884	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	7780656
		1884	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	9303569
		4440	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10193663
		4440	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	7780656
		4440	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	9303569
		45	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10193663
		45	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	7780656
		45	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	9303569
		CHEMBL1278	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10193663
		CHEMBL1278	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	7780656
		CHEMBL1278	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	9303569
		DB00952	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	10193663
		DB00952	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	7780656
		DB00952	9512	58	None	3	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	5	2	3	2.1	CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C	9303569
		40	8329	58	None	2	5	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10193663
		77993	8329	58	None	2	5	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10193663
		995	8329	58	None	2	5	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10193663
		CHEMBL1510	8329	58	None	2	5	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10193663
		DB00216	8329	58	None	2	5	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10193663
		2869	10924	89	None	-2	7	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10193663
		60	10924	89	None	-2	7	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10193663
		60857	10924	89	None	-2	7	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10193663
		CHEMBL1185	10924	89	None	-2	7	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10193663
		DB00315	10924	89	None	-2	7	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10193663
		132059	9016	57	None	-1	3	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	411	7	3	6	2.7	NCCc1c[nH]c2c1cc(cc2)c1onc(n1)Cc1ccc(cc1)NS(=O)(=O)C	9855638
		15	9016	57	None	-1	3	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	411	7	3	6	2.7	NCCc1c[nH]c2c1cc(cc2)c1onc(n1)Cc1ccc(cc1)NS(=O)(=O)C	9855638
		CHEMBL39317	9016	57	None	-1	3	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	411	7	3	6	2.7	NCCc1c[nH]c2c1cc(cc2)c1onc(n1)Cc1ccc(cc1)NS(=O)(=O)C	9855638
		1043	8363	14	None	-23	29	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10715164
		149	8363	14	None	-23	29	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10715164
		8223	8363	14	None	-23	29	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10715164
		CHEMBL442	8363	14	None	-23	29	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10715164
		DB00696	8363	14	None	-23	29	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10715164
		10287730	10309	40	None	251	12	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	15887956
		77	10309	40	None	251	12	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	15887956
		CHEMBL425190	10309	40	None	251	12	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	15887956
		10531	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	1652050
		10531	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8967979
		10531	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	9605573
		121	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	1652050
		121	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8967979
		121	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	9605573
		888	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	1652050
		888	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8967979
		888	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	9605573
		CHEMBL1732	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	1652050
		CHEMBL1732	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8967979
		CHEMBL1732	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	9605573
		DB00320	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	1652050
		DB00320	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8967979
		DB00320	8202	21	None	-4	24	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	9605573
		202	8290	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	8290	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	8290	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	8290	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	8290	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		119570	9933	96	None	-208	39	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	9933	96	None	-208	39	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	9933	96	None	-208	39	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	9933	96	None	-208	39	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	9933	96	None	-208	39	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		179	7188	115	None	-38	50	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	7188	115	None	-38	50	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	7188	115	None	-38	50	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	7188	115	None	-38	50	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	7188	115	None	-38	50	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		228	7233	28	None	-1	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	7233	28	None	-1	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	7233	28	None	-1	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	7233	28	None	-1	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	7233	28	None	-1	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		3337	213146	27	None	-60	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	None	-60	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	None	-60	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	None	-60	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	None	-60	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		29	7579	0	None	-12589	9	Human	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
		9805719	7579	0	None	-12589	9	Human	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
		CHEMBL2027925	7579	0	None	-12589	9	Human	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
		6918515	9390	38	None	-190	7	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
		71	9390	38	None	-190	7	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
		CHEMBL7318	9390	38	None	-190	7	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
		2337	10030	77	None	-89	62	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	8935801
		50	10030	77	None	-89	62	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	8935801
		5002	10030	77	None	-89	62	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	8935801
		CHEMBL716	10030	77	None	-89	62	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	8935801
		DB01224	10030	77	None	-89	62	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	8935801
		2470	10425	50	None	-23988	58	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1565658
		2470	10425	50	None	-23988	58	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1652050
		3300	10425	50	None	-23988	58	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1565658
		3300	10425	50	None	-23988	58	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1652050
		5265	10425	50	None	-23988	58	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1565658
		5265	10425	50	None	-23988	58	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1652050
		99	10425	50	None	-23988	58	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1565658
		99	10425	50	None	-23988	58	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1652050
		CHEMBL267930	10425	50	None	-23988	58	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1565658
		CHEMBL267930	10425	50	None	-23988	58	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1652050
		143	10288	51	None	-177	6	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
		5311096	10288	51	None	-177	6	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
		CHEMBL85606	10288	51	None	-177	6	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
		1574	6869	60	None	-12	21	Human	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	1565658
		1574	6869	60	None	-12	21	Human	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8967979
		218	6869	60	None	-12	21	Human	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	1565658
		218	6869	60	None	-12	21	Human	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8967979
		CHEMBL266591	6869	60	None	-12	21	Human	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	1565658
		CHEMBL266591	6869	60	None	-12	21	Human	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8967979
		1222	8445	49	None	-512	32	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8935801
		3396	8445	49	None	-512	32	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8935801
		85	8445	49	None	-512	32	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8935801
		CHEMBL46516	8445	49	None	-512	32	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8935801
		DB04842	8445	49	None	-512	32	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8935801
		18971832	9196	0	None	-97	13	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
		21	9196	0	None	-97	13	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
		CHEMBL3186179	9196	0	None	-97	13	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
		135398745	9688	112	None	-147	65	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8935801
		47	9688	112	None	-147	65	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8935801
		CHEMBL715	9688	112	None	-147	65	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8935801
		DB00334	9688	112	None	-147	65	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8935801
		130	10273	47	None	-120	13	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9548813
		130	10273	47	None	-120	13	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9776361
		3378093	10273	47	None	-120	13	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9548813
		3378093	10273	47	None	-120	13	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9776361
		CHEMBL281350	10273	47	None	-120	13	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9548813
		CHEMBL281350	10273	47	None	-120	13	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9776361
		152	7152	29	None	-34	19	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8967979
		2107	7152	29	None	-34	19	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8967979
		CHEMBL275854	7152	29	None	-34	19	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8967979
		135398737	7745	93	None	-99	90	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8935801
		38	7745	93	None	-99	90	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8935801
		722	7745	93	None	-99	90	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8935801
		CHEMBL42	7745	93	None	-99	90	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8935801
		DB00363	7745	93	None	-99	90	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8935801
		12	8335	17	None	-12	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
		6918513	8335	17	None	-12	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
		CHEMBL267615	8335	17	None	-12	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
		1353	8692	93	None	-371	85	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8935801
		3559	8692	93	None	-371	85	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8935801
		86	8692	93	None	-371	85	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8935801
		CHEMBL54	8692	93	None	-371	85	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8935801
		DB00502	8692	93	None	-371	85	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8935801
		1355	8792	88	None	-12	16	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	1652050
		142	8792	88	None	-12	16	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	1652050
		CHEMBL478	8792	88	None	-12	16	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	1652050
		DB12110	8792	88	None	-12	16	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	1652050
		2181	9902	46	None	-74	34	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	8935801
		4830	9902	46	None	-74	34	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	8935801
		92	9902	46	None	-74	34	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	8935801
		CHEMBL440294	9902	46	None	-74	34	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	8935801
		DB09286	9902	46	None	-74	34	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	8935801
		129	10213	10	None	-446	8	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
		9868452	10213	10	None	-446	8	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
		CHEMBL65280	10213	10	None	-446	8	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
		1150	10650	121	None	-3	25	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	1565658
		1150	10650	121	None	-3	25	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8967979
		125	10650	121	None	-3	25	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	1565658
		125	10650	121	None	-3	25	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8967979
		CHEMBL6640	10650	121	None	-3	25	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	1565658
		CHEMBL6640	10650	121	None	-3	25	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8967979
		DB08653	10650	121	None	-3	25	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	1565658
		DB08653	10650	121	None	-3	25	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8967979
		1220	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10193663
		1220	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8967979
		1220	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9303569
		31	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10193663
		31	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8967979
		31	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9303569
		7	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10193663
		7	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8967979
		7	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9303569
		CHEMBL56	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10193663
		CHEMBL56	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8967979
		CHEMBL56	6975	55	None	-95	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9303569
		219050	10146	25	None	-436	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	10431754
		219050	10146	25	None	-436	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
		52	10146	25	None	-436	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	10431754
		52	10146	25	None	-436	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
		CHEMBL431367	10146	25	None	-436	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	10431754
		CHEMBL431367	10146	25	None	-436	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
		132	8058	13	None	-2344	15	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	1652050
		155346	8058	13	None	-2344	15	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	1652050
		CHEMBL378501	8058	13	None	-2344	15	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	1652050
		141	8209	35	None	-1	22	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	8967979
		6089	8209	35	None	-1	22	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	8967979
		CHEMBL12420	8209	35	None	-1	22	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	8967979
		DB01488	8209	35	None	-1	22	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	8967979
		115	10563	80	None	-2	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	1565658
		115	10563	80	None	-2	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	1652050
		4296	10563	80	None	-2	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	1565658
		4296	10563	80	None	-2	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	1652050
		CHEMBL274866	10563	80	None	-2	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	1565658
		CHEMBL274866	10563	80	None	-2	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	1652050
		2435	10362	83	None	-52	48	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	8935801
		60149	10362	83	None	-52	48	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	8935801
		98	10362	83	None	-52	48	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	8935801
		CHEMBL12713	10362	83	None	-52	48	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	8935801
		DB06144	10362	83	None	-52	48	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	8935801
		102	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10611634
		102	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1565658
		102	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1652050
		102	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8967979
		3659	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10611634
		3659	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1565658
		3659	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1652050
		3659	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8967979
		8969	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10611634
		8969	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1565658
		8969	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1652050
		8969	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8967979
		CHEMBL15245	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10611634
		CHEMBL15245	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1565658
		CHEMBL15245	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1652050
		CHEMBL15245	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8967979
		DB01392	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10611634
		DB01392	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1565658
		DB01392	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1652050
		DB01392	10899	48	None	-102	49	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8967979
		1524	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8967979
		1524	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9303569
		197	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8967979
		197	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9303569
		3822	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8967979
		3822	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9303569
		88	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8967979
		88	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9303569
		CHEMBL51	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8967979
		CHEMBL51	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9303569
		DB12465	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8967979
		DB12465	8962	96	None	-257	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9303569
		5074	10105	80	None	-323	30	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8967979
		97	10105	80	None	-323	30	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8967979
		CHEMBL267777	10105	80	None	-323	30	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8967979
		DB12693	10105	80	None	-323	30	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8967979
		28	10269	46	None	-13	10	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		3292447	10269	46	None	-13	10	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		CHEMBL20963	10269	46	None	-13	10	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		126	10842	8	None	-19	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.5	COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1	9208142
		6604840	10842	8	None	-19	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.5	COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1	9208142
		CHEMBL38288	10842	8	None	-19	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.5	COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1	9208142
		108029	10187	57	None	-19	13	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	1652050
		23	10187	57	None	-19	13	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	1652050
		CHEMBL18785	10187	57	None	-19	13	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	1652050
		4106	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	1652050
		4106	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8957260
		4106	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8967979
		4106	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9303569
		5358812	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	1652050
		5358812	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8957260
		5358812	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8967979
		5358812	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9303569
		89	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	1652050
		89	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8957260
		89	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8967979
		89	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9303569
		CHEMBL93240	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	1652050
		CHEMBL93240	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8957260
		CHEMBL93240	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8967979
		CHEMBL93240	9280	22	None	-44	33	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9303569
		136	10065	32	None	-25	16	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1565658
		223	10065	32	None	-25	16	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1565658
		643606	10065	32	None	-25	16	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1565658
		CHEMBL10347	10065	32	None	-25	16	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1565658
		2601	10552	33	None	-14	21	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		443951	10552	33	None	-14	21	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		56	10552	33	None	-14	21	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		CHEMBL73151	10552	33	None	-14	21	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		DB13399	10552	33	None	-14	21	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		10257	7525	31	None	-5	19	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8967979
		144	7525	31	None	-5	19	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8967979
		CHEMBL416526	7525	31	None	-5	19	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8967979
		DB01445	7525	31	None	-5	19	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8967979
		475100	6977	0	None	-12	6	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	4	1	7	2.6	OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F	8935801
		67	6977	0	None	-12	6	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	4	1	7	2.6	OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F	8935801
		CHEMBL3542429	6977	0	None	-12	6	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	4	1	7	2.6	OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F	8935801
		2105	9828	37	None	-4	32	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		47811	9828	37	None	-4	32	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		48	9828	37	None	-4	32	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		CHEMBL531	9828	37	None	-4	32	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		DB01186	9828	37	None	-4	32	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		31101	7516	40	None	-13	35	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		35	7516	40	None	-13	35	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		403	7516	40	None	-13	35	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		CHEMBL493	7516	40	None	-13	35	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		DB01200	7516	40	None	-13	35	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		107	6929	121	None	-8	31	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	1565658
		107	6929	121	None	-8	31	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	1652050
		107	6929	121	None	-8	31	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8967979
		1833	6929	121	None	-8	31	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	1565658
		1833	6929	121	None	-8	31	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	1652050
		1833	6929	121	None	-8	31	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8967979
		CHEMBL8165	6929	121	None	-8	31	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	1565658
		CHEMBL8165	6929	121	None	-8	31	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	1652050
		CHEMBL8165	6929	121	None	-8	31	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8967979
		37	7565	60	None	-3	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		460	7565	60	None	-3	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		54746	7565	60	None	-3	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		CHEMBL1201087	7565	60	None	-3	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		DB00248	7565	60	None	-3	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		1342	6824	49	None	-3	19	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	1565658
		1342	6824	49	None	-3	19	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9397179
		3	6824	49	None	-3	19	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	1565658
		3	6824	49	None	-3	19	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9397179
		CHEMBL277120	6824	49	None	-3	19	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	1565658
		CHEMBL277120	6824	49	None	-3	19	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9397179
		3652	10869	79	None	2	18	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		57	10869	79	None	2	18	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		60809	10869	79	None	2	18	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		CHEMBL21536	10869	79	None	2	18	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		DB15357	10869	79	None	2	18	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		163091	7282	34	None	-66	10	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	8935801
		22	7282	34	None	-66	10	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	8935801
		CHEMBL504548	7282	34	None	-66	10	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	8935801
		107780	8625	54	None	-1	18	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	8967979
		14	8625	54	None	-1	18	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	8967979
		CHEMBL15928	8625	54	None	-1	18	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	8967979
		5	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10431754
		5	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1565658
		5	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1652050
		5	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8957260
		5	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8967979
		5	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9208142
		5	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9776361
		5202	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10431754
		5202	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1565658
		5202	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1652050
		5202	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8957260
		5202	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8967979
		5202	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9208142
		5202	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9776361
		CHEMBL39	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10431754
		CHEMBL39	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1565658
		CHEMBL39	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1652050
		CHEMBL39	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8957260
		CHEMBL39	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8967979
		CHEMBL39	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9208142
		CHEMBL39	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9776361
		DB08839	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10431754
		DB08839	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1565658
		DB08839	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1652050
		DB08839	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8957260
		DB08839	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8967979
		DB08839	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9208142
		DB08839	6927	72	None	-6	53	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9776361
		109	7689	31	None	1	7	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	1565658
		109	7689	31	None	1	7	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	1652050
		2689	7689	31	None	1	7	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	1565658
		2689	7689	31	None	1	7	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	1652050
		CHEMBL27403	7689	31	None	1	7	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	1565658
		CHEMBL27403	7689	31	None	1	7	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	1652050
		134	9292	24	None	-13	67	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	1565658
		134	9292	24	None	-13	67	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8967979
		1775	9292	24	None	-13	67	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	1565658
		1775	9292	24	None	-13	67	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8967979
		9681	9292	24	None	-13	67	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	1565658
		9681	9292	24	None	-13	67	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8967979
		CHEMBL1065	9292	24	None	-13	67	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	1565658
		CHEMBL1065	9292	24	None	-13	67	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8967979
		DB00247	9292	24	None	-13	67	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	1565658
		DB00247	9292	24	None	-13	67	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8967979
		75	10287	7	None	3	3	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	11454652
		9870500	10287	7	None	3	3	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	11454652
		CHEMBL191971	10287	7	None	3	3	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	11454652
		46	9680	0	None	-8	5	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	420	4	0	6	4.0	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C	8967979
		71351	9680	0	None	-8	5	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	420	4	0	6	4.0	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C	8967979
		CHEMBL2104619	9680	0	None	-8	5	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	420	4	0	6	4.0	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C	8967979
		DB06229	9680	0	None	-8	5	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	420	4	0	6	4.0	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C	8967979
		10296414	10304	15	None	-1	9	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	15887956
		76	10304	15	None	-1	9	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	15887956
		CHEMBL183460	10304	15	None	-1	9	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	15887956
		107780	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	8957260
		107780	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		107780	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9397179
		107780	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9548813
		107780	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9776361
		14	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	8957260
		14	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		14	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9397179
		14	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9548813
		14	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9776361
		CHEMBL15928	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	8957260
		CHEMBL15928	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
		CHEMBL15928	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9397179
		CHEMBL15928	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9548813
		CHEMBL15928	8625	54	None	-1	18	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9776361
		1809	6922	32	None	-10	37	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	1565658
		1809	6922	32	None	-10	37	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	1652050
		1809	6922	32	None	-10	37	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8967979
		4	6922	32	None	-10	37	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	1565658
		4	6922	32	None	-10	37	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	1652050
		4	6922	32	None	-10	37	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8967979
		CHEMBL18840	6922	32	None	-10	37	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	1565658
		CHEMBL18840	6922	32	None	-10	37	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	1652050
		CHEMBL18840	6922	32	None	-10	37	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8967979
		133	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	1652050
		133	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8967979
		133	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9303569
		1723	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	1652050
		1723	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8967979
		1723	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9303569
		28693	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	1652050
		28693	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8967979
		28693	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9303569
		CHEMBL19215	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	1652050
		CHEMBL19215	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8967979
		CHEMBL19215	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9303569
		DB13520	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	1652050
		DB13520	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8967979
		DB13520	9274	52	None	-3	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9303569
		122130461	9206	0	None	1584	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	268	1	2	2	2.1	CN1C[C@@H](C=C2C1Cc1c[nH]c3c1c2ccc3)C(=O)O	8967979
		139	9206	0	None	1584	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	268	1	2	2	2.1	CN1C[C@@H](C=C2C1Cc1c[nH]c3c1c2ccc3)C(=O)O	8967979
		6717	9206	0	None	1584	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	268	1	2	2	2.1	CN1C[C@@H](C=C2C1Cc1c[nH]c3c1c2ccc3)C(=O)O	8967979
		1588	9105	27	None	-48	44	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		28864	9105	27	None	-48	44	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		43	9105	27	None	-48	44	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		CHEMBL157138	9105	27	None	-48	44	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		DB00589	9105	27	None	-48	44	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		2865	10915	73	None	-7	53	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	8935801
		59	10915	73	None	-7	53	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	8935801
		60854	10915	73	None	-7	53	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	8935801
		CHEMBL708	10915	73	None	-7	53	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	8935801
		DB00246	10915	73	None	-7	53	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	8935801
		117	7141	19	None	1	2	Human	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	8967979
		117	7141	19	None	1	2	Human	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	9605573
		120	7141	19	None	1	2	Human	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	8967979
		120	7141	19	None	1	2	Human	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	9605573
		66004	7141	19	None	1	2	Human	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	8967979
		66004	7141	19	None	1	2	Human	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	9605573
		CHEMBL88240	7141	19	None	1	2	Human	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	8967979
		CHEMBL88240	7141	19	None	1	2	Human	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	302	6	3	5	1.3	C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1	9605573
		14533720	6970	0	None	3	3	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	275	6	1	3	2.2	O=C(OCC1OC1)NCC[Si]([Si](C)(C)C)(C)C	9397179
		6	6970	0	None	3	3	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	275	6	1	3	2.2	O=C(OCC1OC1)NCC[Si]([Si](C)(C)C)(C)C	9397179
		123	9208	41	None	10	3	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	1	2	2	2.0	OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3	1565658
		14987	9208	41	None	10	3	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	1	2	2	2.0	OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3	1565658
		CHEMBL39947	9208	41	None	10	3	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	1	2	2	2.0	OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3	1565658
		197706	8246	0	None	-2	10	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	2	5	2.3	NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2	10381763
		39	8246	0	None	-2	10	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	2	5	2.3	NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2	10381763
		CHEMBL1742428	8246	0	None	-2	10	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	2	5	2.3	NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2	10381763
		103	10925	61	None	-19	53	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	8935801
		2875	10925	61	None	-19	53	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	8935801
		5736	10925	61	None	-19	53	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	8935801
		CHEMBL285802	10925	61	None	-19	53	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	8935801
		DB09225	10925	61	None	-19	53	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	8935801
		124	9755	47	None	-1	32	Human	9.4	pKi	None	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9632357
		2032	9755	47	None	-1	32	Human	9.4	pKi	None	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9632357
		4636	9755	47	None	-1	32	Human	9.4	pKi	None	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9632357
		CHEMBL762	9755	47	None	-1	32	Human	9.4	pKi	None	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9632357
		DB00935	9755	47	None	-1	32	Human	9.4	pKi	None	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9632357
		197706	8246	0	None	-1	10	Rat	9.6	pKi	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	2	5	2.3	NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2	10381763
		39	8246	0	None	-1	10	Rat	9.6	pKi	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	2	5	2.3	NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2	10381763
		CHEMBL1742428	8246	0	None	-1	10	Rat	9.6	pKi	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	2	5	2.3	NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2	10381763

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Ligand source activities (1 row/activity)