Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1153	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	12668023	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026874	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026875	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	3341	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	6603851	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	933	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	939	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	985	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1160786	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1161520	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL588	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	DB00800	1615	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	2407	3347	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3347	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3347	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3347	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3347	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	138	3059	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	1882	3059	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	5280723	3059	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	CHEMBL495	3059	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	DB00770	3059	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	4150	785	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	785	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	785	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	785	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	785	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	2389	3306	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3306	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3306	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3306	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3306	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2105	3032	37	None	-85	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3032	37	None	-85	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3032	37	None	-85	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3032	37	None	-85	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3032	37	None	-85	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	3042	1402	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1402	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1402	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1402	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1402	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	17676	7040	29	None	-77	13	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7040	29	None	-77	13	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7040	29	None	-77	13	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	11001318	78121	69	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	2	1	3	4.5	O=C(O)c1ccc2nc(-c3cc(Cl)cc(Cl)c3)oc2c1	10.1038/s41467-023-40064-9
	CHEMBL2103837	78121	69	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	2	1	3	4.5	O=C(O)c1ccc2nc(-c3cc(Cl)cc(Cl)c3)oc2c1	10.1038/s41467-023-40064-9
	135398737	955	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	36811	1442	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	535	1442	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	937	1442	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL926	1442	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00841	1442	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	25102847	78192	93	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78192	93	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	228	444	28	None	-14	20	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	444	28	None	-14	20	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	444	28	None	-14	20	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	444	28	None	-14	20	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	444	28	None	-14	20	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	168871	89101	14	None	1	13	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89101	14	None	1	13	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	6077	150674	31	None	-44	11	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL39560	150674	31	None	-44	11	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	54682461	84657	62	None	-3	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84657	62	None	-3	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	55645	84341	8	None	-53	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84341	8	None	-53	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	31101	726	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	26879	37264	63	None	13	2	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	204	1	0	3	2.1	c1ccc([C@H]2CN3CCSC3=N2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1454	37264	63	None	13	2	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	204	1	0	3	2.1	c1ccc([C@H]2CN3CCSC3=N2)cc1	10.1038/s41467-023-40064-9
	24826799	10766	104	None	-50	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10766	104	None	-50	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	2335	11816	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11816	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11816	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11816	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	4066	204603	78	None	-1071	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204603	78	None	-1071	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	154257	178595	67	None	-77	19	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178595	67	None	-77	19	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	54454	5226	88	None	-2	14	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5226	88	None	-2	14	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	60606	61530	73	None	-9	8	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61530	73	None	-9	8	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	102	4096	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4096	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4096	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4096	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4096	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	5284537	33583	31	None	2	2	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	374	1	1	3	4.0	CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL142130	33583	31	None	2	2	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	374	1	1	3	4.0	CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	1201549	594	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	594	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	594	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	594	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	594	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	594	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2136	3073	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3073	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3073	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3073	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3073	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	10184665	3960	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3960	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3960	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3960	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3960	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	1209	1645	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1645	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1645	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1645	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1645	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	55483	205074	40	None	-144	11	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	CHEMBL77622	205074	40	None	-144	11	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	46780481	107504	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107504	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107504	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107504	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	71137	78214	18	None	-	1	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	12	2	9	2.7	CCOC(=O)Oc1ccc(CCNC(=O)[C@H](CCSC)NC(C)=O)cc1OC(=O)OCC	10.1038/s41467-023-40064-9
	CHEMBL2106351	78214	18	None	-	1	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	12	2	9	2.7	CCOC(=O)Oc1ccc(CCNC(=O)[C@H](CCSC)NC(C)=O)cc1OC(=O)OCC	10.1038/s41467-023-40064-9
	104850	3305	96	None	-2290	28	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3305	96	None	-2290	28	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3305	96	None	-2290	28	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3305	96	None	-2290	28	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3305	96	None	-2290	28	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	135564886	14461	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	135673376	14461	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	137157436	14461	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	145948239	14461	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	71587099	14461	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1201304	14461	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	71496458	115538	87	None	-72	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115538	87	None	-72	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	150	2492	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2492	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2492	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2492	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2492	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1960	2838	67	None	-25	19	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	2838	67	None	-25	19	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	2838	67	None	-25	19	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	2838	67	None	-25	19	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	2838	67	None	-25	19	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	213046	2370	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2370	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2370	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2370	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2370	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	2146	3078	67	None	-851	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	3078	67	None	-851	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	3078	67	None	-851	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	3078	67	None	-851	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	3078	67	None	-851	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL508338	188942	0	None	-89	15	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	1028	289	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	289	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	289	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	289	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	289	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	289	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	135398745	2893	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2893	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2893	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2893	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-208	36	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-208	36	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-208	36	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	10531	1408	21	None	-1949	26	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1408	21	None	-1949	26	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1408	21	None	-1949	26	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1408	21	None	-1949	26	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1408	21	None	-1949	26	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	37	775	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	775	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	775	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	775	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	775	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	1816	2523	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2523	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2523	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2523	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2523	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	2865	4112	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4112	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4112	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4112	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4112	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	68555	103085	21	None	3	7	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	CHEMBL307739	103085	21	None	3	7	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	214	3831	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3831	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3831	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3831	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3831	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3831	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	25382	9125	37	None	-120	21	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9125	37	None	-120	21	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	49806720	60050	99	None	-9	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1738797	60050	99	None	-9	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	5472	205795	75	None	-7	16	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1717	205795	75	None	-7	16	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL833	205795	75	None	-7	16	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2601	3751	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3751	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3751	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3751	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3751	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	242	469	124	None	-794	33	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-794	33	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-794	33	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-794	33	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-794	33	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	103	4122	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4122	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4122	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4122	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4122	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	3718	52007	73	None	-	1	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	281	3	1	2	3.0	CC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL15870	52007	73	None	-	1	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	281	3	1	2	3.0	CC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	1043	1569	14	None	-5011	23	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	1569	14	None	-5011	23	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	1569	14	None	-5011	23	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	1569	14	None	-5011	23	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	1569	14	None	-5011	23	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	1353	1898	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2220	3112	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3112	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3112	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3112	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3112	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	2337	3232	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5852	2599	55	None	-91	6	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9931891	2599	55	None	-91	6	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL239226	2599	55	None	-91	6	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	16363	593	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	593	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	593	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	593	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	593	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	1830	2572	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2572	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2572	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2572	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2572	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	681	1453	72	None	-77	15	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	940	1453	72	None	-77	15	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	947	1453	72	None	-77	15	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL59	1453	72	None	-77	15	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00988	1453	72	None	-77	15	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	212	3777	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3777	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3777	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3777	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3777	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	10020353	13857	18	None	12022	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL1196161	13857	18	None	12022	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL556024	13857	18	None	12022	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	133538	3592	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	8443	3592	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL574558	3592	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	146025713	171587	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465393	171587	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025713	171587	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465393	171587	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75201901	166401	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166401	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75201901	166401	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166401	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75202022	170786	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1016/j.ejmech.2022.114378
	CHEMBL4453318	170786	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1016/j.ejmech.2022.114378
	16219951	172036	2	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL4472022	172036	2	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	75202022	170786	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL4453318	170786	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	173871	3587	2	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/acs.jmedchem.8b00435
	936	3587	2	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1193571	3587	2	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/acs.jmedchem.8b00435
	46869265	16225	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
	CHEMBL1224527	16225	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
	10742	3590	31	None	4	3	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	1225	3590	31	None	4	3	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL35354	3590	31	None	4	3	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	92044504	171703	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4467080	171703	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	92044504	171703	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4467080	171703	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	1241	100151	24	None	22	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL288090	100151	24	None	22	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL552611	100151	24	None	22	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	44320092	161863	0	None	346	2	Human	9.0	pEC50	=	9.0	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL415080	161863	0	None	346	2	Human	9.0	pEC50	=	9.0	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	167715	2856	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	969	2856	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL225230	2856	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	167715	2856	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	969	2856	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL225230	2856	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	1242	3586	27	None	1	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/acs.jmedchem.8b00435
	935	3586	27	None	1	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/acs.jmedchem.8b00435
	CHEMBL286080	3586	27	None	1	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/acs.jmedchem.8b00435
	10506	2507	20	None	20	3	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.8b01767
	86290953	2507	20	None	20	3	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.8b01767
	CHEMBL3421729	2507	20	None	20	3	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.8b01767
	135	169258	123	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	138	1	2	2	1.1	O=C(O)c1ccc(O)cc1	10.1021/acs.jmedchem.8b01767
	3702506	169258	123	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	138	1	2	2	1.1	O=C(O)c1ccc(O)cc1	10.1021/acs.jmedchem.8b01767
	CHEMBL441343	169258	123	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	138	1	2	2	1.1	O=C(O)c1ccc(O)cc1	10.1021/acs.jmedchem.8b01767
	75201961	169606	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4437012	169606	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	75201961	169606	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4437012	169606	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	146025701	170547	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	CHEMBL4450338	170547	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	146025701	170547	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	CHEMBL4450338	170547	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	44320024	107040	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315750	107040	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	130442480	175246	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175246	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	44320050	106804	0	None	1	3	Rat	8.8	pEC50	=	8.8	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL314459	106804	0	None	1	3	Rat	8.8	pEC50	=	8.8	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	130442480	175246	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175246	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	146025715	176172	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4593703	176172	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025715	176172	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4593703	176172	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	122324	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	6077	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	CHEMBL86931	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	122324	205	22	None	4	4	Rat	8.7	pEC50	=	8.7	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm9502100
	6077	205	22	None	4	4	Rat	8.7	pEC50	=	8.7	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm9502100
	CHEMBL86931	205	22	None	4	4	Rat	8.7	pEC50	=	8.7	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm9502100
	122324	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	6077	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	CHEMBL86931	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	90134269	174182	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4548284	174182	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	75201899	171892	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
	CHEMBL4469983	171892	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
	71722299	102453	0	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397383	102453	0	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040217	102453	0	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	44282985	120454	0	None	-1	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL35426	120454	0	None	-1	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	146025707	171083	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4457872	171083	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44320256	206290	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87172	206290	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	13720688	11522	0	None	1	2	Rat	7.0	pEC50	=	7	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	329	3	3	4	3.1	C=CCN1CCc2c(cc(O)c(O)c2F)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1180542	11522	0	None	1	2	Rat	7.0	pEC50	=	7	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	329	3	3	4	3.1	C=CCN1CCc2c(cc(O)c(O)c2F)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL129634	11522	0	None	1	2	Rat	7.0	pEC50	=	7	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	329	3	3	4	3.1	C=CCN1CCc2c(cc(O)c(O)c2F)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	146025696	169679	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4437975	169679	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	44331742	4408	0	None	-	1	Rat	6.0	pEC50	=	6	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	269	3	3	3	2.7	Oc1ccc2c(c1O)CCC(NCc1ccccc1)C2	10.1021/jm9502100
	CHEMBL101617	4408	0	None	-	1	Rat	6.0	pEC50	=	6	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	269	3	3	3	2.7	Oc1ccc2c(c1O)CCC(NCc1ccccc1)C2	10.1021/jm9502100
	14708665	168181	1	None	-	1	Rat	5.0	pEC50	=	5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	CHEMBL43345	168181	1	None	-	1	Rat	5.0	pEC50	=	5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	146025696	169679	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4437975	169679	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	146025707	171083	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4457872	171083	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75201901	166401	19	None	95	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166401	19	None	95	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	146034919	192176	3	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2cccc(OC(F)F)c2)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5204559	192176	3	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2cccc(OC(F)F)c2)cc1	10.1021/acs.jmedchem.2c00949
	146025721	171685	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4466769	171685	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	10684715	160616	0	None	-	1	Goldfish	8.0	pEC50	=	8.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL41132	160616	0	None	-	1	Goldfish	8.0	pEC50	=	8.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	71563083	87543	0	None	19	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335737	87543	0	None	19	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	75201901	166401	19	None	95	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
	CHEMBL4277264	166401	19	None	95	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
	146025721	171685	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4466769	171685	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	44276535	98361	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	CHEMBL275379	98361	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	44417647	82132	0	None	-52	3	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	CHEMBL1203924	82132	0	None	-52	3	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	CHEMBL216945	82132	0	None	-52	3	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	24878061	141386	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
	CHEMBL384046	141386	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
	146025709	174557	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4556763	174557	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	145982261	166708	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	CHEMBL4283176	166708	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	146192959	170491	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1cc(F)ccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4449550	170491	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1cc(F)ccc1Cl	10.1021/acsmedchemlett.9b00547
	44282985	120454	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL35426	120454	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	130442557	167049	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4289538	167049	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	146025709	174557	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4556763	174557	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	71722297	102445	0	None	-34	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397382	102445	0	None	-34	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040156	102445	0	None	-34	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	85090332	180695	0	None	-9	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4755709	180695	0	None	-9	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	90134199	172218	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4474245	172218	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	90134199	172218	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4474245	172218	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	44320303	163943	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL420788	163943	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	130442471	176060	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4591207	176060	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	681	1453	72	None	-77	15	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	940	1453	72	None	-77	15	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	947	1453	72	None	-77	15	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	CHEMBL59	1453	72	None	-77	15	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	DB00988	1453	72	None	-77	15	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	44554468	106241	0	None	-151	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	233	1	1	3	1.6	CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099225	106241	0	None	-151	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	233	1	1	3	1.6	CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139011	106241	0	None	-151	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	233	1	1	3	1.6	CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	146025716	173941	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4541632	173941	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44276651	99712	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL284959	99712	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	85090319	180586	0	None	-5	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4754602	180586	0	None	-5	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	130442534	166873	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4286177	166873	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	2030130	20947	16	None	-6	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL1311333	20947	16	None	-6	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	146025716	173941	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4541632	173941	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	145988779	167255	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
	CHEMBL4293356	167255	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
	44320328	206205	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
	CHEMBL86669	206205	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
	10689581	100135	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL287931	100135	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	3106	48490	16	None	-25	3	Rat	4.9	pEC50	=	4.9	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1021/jm00390a009
	CHEMBL15564	48490	16	None	-25	3	Rat	4.9	pEC50	=	4.9	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1021/jm00390a009
	168278276	191092	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	295	5	1	3	2.6	CNS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5187937	191092	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	295	5	1	3	2.6	CNS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	146192950	176007	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	397	4	2	3	3.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1F	10.1021/acsmedchemlett.9b00547
	CHEMBL4590150	176007	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	397	4	2	3	3.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1F	10.1021/acsmedchemlett.9b00547
	168280742	191060	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	230	4	0	2	3.5	O=Cc1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5187578	191060	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	230	4	0	2	3.5	O=Cc1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	130442471	176060	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4591207	176060	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	146192960	171495	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4464150	171495	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	44320116	164084	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL420972	164084	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	117720272	118788	3	None	18	3	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	CHEMBL3421730	118788	3	None	18	3	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	1242	3586	27	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.12.016
	935	3586	27	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.12.016
	CHEMBL286080	3586	27	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.12.016
	146025697	175327	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4574454	175327	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	168276676	190438	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	280	4	0	3	3.1	CS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5178743	190438	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	280	4	0	3	3.1	CS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	146025697	175327	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4574454	175327	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	130442561	166869	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4286110	166869	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	161665	172561	35	None	-28	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL448891	172561	35	None	-28	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	85090324	180668	0	None	-4	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4755481	180668	0	None	-4	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	6603820	95745	19	None	1	7	Human	7.9	pEC50	=	7.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL25856	95745	19	None	1	7	Human	7.9	pEC50	=	7.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	146025712	175459	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4577432	175459	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	10666053	100358	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL289927	100358	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	146025703	171243	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4460394	171243	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	75201901	166401	19	None	95	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166401	19	None	95	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	146025703	171243	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4460394	171243	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	15696481	79637	0	None	75	2	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL2115213	79637	0	None	75	2	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	146025712	175459	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4577432	175459	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	132435	130683	6	None	8	2	Rat	7.8	pEC50	=	7.8	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	345	3	3	4	3.6	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL130795	130683	6	None	8	2	Rat	7.8	pEC50	=	7.8	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	345	3	3	4	3.6	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL368456	130683	6	None	8	2	Rat	7.8	pEC50	=	7.8	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	345	3	3	4	3.6	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	146025704	172324	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4475848	172324	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44554818	104239	0	None	-89	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099234	104239	0	None	-89	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	44554472	106256	0	None	-1071	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	247	2	1	3	2.0	CCCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099226	106256	0	None	-1071	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	247	2	1	3	2.0	CCCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139040	106256	0	None	-1071	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	247	2	1	3	2.0	CCCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	85090328	181011	0	None	-6	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4759339	181011	0	None	-6	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090323	181898	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4779641	181898	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
	146025813	175563	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	175563	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025813	175563	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	175563	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	90134304	166490	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b00435
	CHEMBL4278861	166490	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b00435
	146025821	169647	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4437552	169647	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025821	169647	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4437552	169647	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025820	173198	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4523054	173198	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025820	173198	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4523054	173198	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	85090329	182658	0	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4789255	182658	0	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	137364078	192201	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	4	0	3	3.7	CN=S(C)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5204914	192201	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	4	0	3	3.7	CN=S(C)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	3246443	37656	2	None	-16	3	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL1457510	37656	2	None	-16	3	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	146025704	172324	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4475848	172324	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44320053	205750	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL82899	205750	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	11938	2396	7	None	11	4	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	146192952	2396	7	None	11	4	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4468760	2396	7	None	11	4	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	44287454	13196	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL1191276	13196	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL542351	13196	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	146025718	175169	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4570859	175169	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	117720272	118788	3	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421730	118788	3	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	146025718	175169	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4570859	175169	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	85090333	181277	0	None	-10	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4762375	181277	0	None	-10	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	76284419	183224	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4796389	183224	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
	85090325	179725	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4744261	179725	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	75201901	166401	19	None	95	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b00435
	CHEMBL4277264	166401	19	None	95	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b00435
	10854877	141990	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL38757	141990	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	10733562	146989	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL39266	146989	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
	1242	3586	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assayAgonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.05.057
	935	3586	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assayAgonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.05.057
	CHEMBL286080	3586	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assayAgonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.05.057
	136326241	179404	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4740312	179404	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	146192966	175292	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acsmedchemlett.9b00547
	CHEMBL4573538	175292	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acsmedchemlett.9b00547
	44319988	206056	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85552	206056	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10758745	100405	0	None	-	1	Goldfish	5.8	pEC50	=	5.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115373	100405	0	None	-	1	Goldfish	5.8	pEC50	=	5.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL290438	100405	0	None	-	1	Goldfish	5.8	pEC50	=	5.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	44276414	97600	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL27101	97600	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	155548298	173727	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	473	6	2	5	3.9	C[C@H]1c2cccc(-c3cnn(CCO)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4536851	173727	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	473	6	2	5	3.9	C[C@H]1c2cccc(-c3cnn(CCO)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	44320001	205993	0	None	-3	2	Rat	7.7	pEC50	=	7.7	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84983	205993	0	None	-3	2	Rat	7.7	pEC50	=	7.7	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	1242	3586	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2014.09.024
	935	3586	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2014.09.024
	CHEMBL286080	3586	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2014.09.024
	146025729	174135	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4546823	174135	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	44276652	99466	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	CHEMBL283247	99466	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	146025729	174135	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4546823	174135	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	85090322	179435	0	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4740678	179435	0	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090321	182789	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4790909	182789	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	168294420	192486	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccccc2OC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5209228	192486	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccccc2OC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	6603820	95745	19	None	1	7	Human	7.7	pEC50	=	7.7	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
	CHEMBL25856	95745	19	None	1	7	Human	7.7	pEC50	=	7.7	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
	44554820	106259	0	None	-31	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	307	4	1	4	2.7	CCCN1C[C@H](CSC)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099222	106259	0	None	-31	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	307	4	1	4	2.7	CCCN1C[C@H](CSC)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139044	106259	0	None	-31	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	307	4	1	4	2.7	CCCN1C[C@H](CSC)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	146025724	172240	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4474567	172240	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025819	175628	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4581262	175628	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025819	175628	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4581262	175628	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025724	172240	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4474567	172240	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	85090334	180601	0	None	-11	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4754761	180601	0	None	-11	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090331	181429	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4764398	181429	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	12668019	10207	8	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
	CHEMBL1160787	10207	8	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
	44320061	106005	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313304	106005	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	14809027	107002	0	None	3	3	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315468	107002	0	None	3	3	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	122324	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	6077	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	CHEMBL86931	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	146025727	171661	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171661	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025727	171661	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171661	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442572	171884	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171884	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442572	171884	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171884	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	10506	2507	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	86290953	2507	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	CHEMBL3421729	2507	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	130442473	167313	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4294397	167313	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442473	167313	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4294397	167313	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	1153	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	12668023	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	30026874	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	30026875	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	3341	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	6603851	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	933	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	939	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	985	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1160786	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1161520	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL588	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	DB00800	1615	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	681	1453	72	None	-77	15	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	940	1453	72	None	-77	15	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	947	1453	72	None	-77	15	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	CHEMBL59	1453	72	None	-77	15	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	DB00988	1453	72	None	-77	15	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	75201899	171892	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1016/j.ejmech.2022.114378
	CHEMBL4469983	171892	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1016/j.ejmech.2022.114378
	201536	111441	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL3276140	111441	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	201536	111441	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL3276140	111441	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	133741	199043	11	None	-38	2	Rat	4.7	pEC50	=	4.7	Functional	Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	276	7	2	3	2.6	CCCN(CCC)CCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	CHEMBL587	199043	11	None	-38	2	Rat	4.7	pEC50	=	4.7	Functional	Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	276	7	2	3	2.6	CCCN(CCC)CCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	90134211	174005	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4543306	174005	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	71722293	102448	0	None	-4	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	CHEMBL2397380	102448	0	None	-4	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	CHEMBL3040164	102448	0	None	-4	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	44554984	104236	0	None	-208	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099231	104236	0	None	-208	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	155541775	173020	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	CHEMBL4519136	173020	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	137364059	190296	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	3.4	C[S+]([O-])c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5176312	190296	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	3.4	C[S+]([O-])c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	168289194	191470	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	4.5	O=Cc1ccc(-c2ccccc2SC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5193714	191470	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	4.5	O=Cc1ccc(-c2ccccc2SC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	10662054	84383	0	None	-	1	Goldfish	7.7	pEC50	=	7.7	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114444	84383	0	None	-	1	Goldfish	7.7	pEC50	=	7.7	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219803	84383	0	None	-	1	Goldfish	7.7	pEC50	=	7.7	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	90134211	174005	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4543306	174005	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	155519631	170381	0	None	15	2	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	CHEMBL4448100	170381	0	None	15	2	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	145979741	166661	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4282096	166661	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	6917970	3665	61	None	40	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	8370	3665	61	None	40	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	CHEMBL487387	3665	61	None	40	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	44276412	97637	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL27117	97637	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	44320116	164084	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL420972	164084	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	44554649	104240	0	None	-457	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099235	104240	0	None	-457	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	44276557	99288	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL282136	99288	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	21936384	191488	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccc(OC(F)F)cc2)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5193924	191488	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccc(OC(F)F)cc2)cc1	10.1021/acs.jmedchem.2c00949
	681	1453	72	None	-77	15	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	940	1453	72	None	-77	15	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	947	1453	72	None	-77	15	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	CHEMBL59	1453	72	None	-77	15	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	DB00988	1453	72	None	-77	15	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	15696482	79530	0	None	21	2	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL2114209	79530	0	None	21	2	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	85090326	182749	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4790277	182749	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	44320218	206401	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
	CHEMBL87897	206401	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
	146025811	171737	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	171737	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025811	171737	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	171737	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	10640108	84382	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114441	84382	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219802	84382	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	9841398	99491	4	None	-2	3	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL28338	99491	4	None	-2	3	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	44320267	206189	0	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86576	206189	0	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10588327	13749	0	None	-	1	Goldfish	6.6	pEC50	=	6.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL1195441	13749	0	None	-	1	Goldfish	6.6	pEC50	=	6.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL554571	13749	0	None	-	1	Goldfish	6.6	pEC50	=	6.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	145990190	166829	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4285528	166829	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	85090337	183257	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4796761	183257	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	21786101	155708	0	None	-38	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	261	2	2	3	2.7	CCCN1CCC[C@@H]2Cc3c(ccc(O)c3O)C[C@H]21	10.1016/j.bmc.2007.06.036
	CHEMBL405519	155708	0	None	-38	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	261	2	2	3	2.7	CCCN1CCC[C@@H]2Cc3c(ccc(O)c3O)C[C@H]21	10.1016/j.bmc.2007.06.036
	1241	100151	24	None	-22	3	Rat	7.6	pEC50	=	7.6	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00384a006
	CHEMBL288090	100151	24	None	-22	3	Rat	7.6	pEC50	=	7.6	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00384a006
	CHEMBL552611	100151	24	None	-22	3	Rat	7.6	pEC50	=	7.6	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00384a006
	228	444	28	None	-14	20	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	33	444	28	None	-14	20	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	6005	444	28	None	-14	20	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	CHEMBL53	444	28	None	-14	20	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	DB00714	444	28	None	-14	20	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	155541775	173020	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	CHEMBL4519136	173020	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	145979741	166661	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b00435
	CHEMBL4282096	166661	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b00435
	145979741	166661	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1016/j.ejmech.2022.114378
	CHEMBL4282096	166661	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1016/j.ejmech.2022.114378
	4901726	180775	9	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4756486	180775	9	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	146025714	170274	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4446525	170274	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025714	170274	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4446525	170274	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	130442473	167313	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4294397	167313	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
	146025730	171944	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4470740	171944	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025730	171944	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4470740	171944	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	9796958	146553	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115374	146553	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL39230	146553	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL544814	146553	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	44320304	107008	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	367	5	3	4	4.5	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNCc1ccccc1	10.1021/jm00112a034
	CHEMBL315516	107008	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	367	5	3	4	4.5	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNCc1ccccc1	10.1021/jm00112a034
	85090318	179421	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4740497	179421	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	10758744	100479	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL291100	100479	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	10710466	156391	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL40667	156391	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	2407	3347	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	59227	3347	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	941	3347	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	CHEMBL1303	3347	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	DB05271	3347	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	146192958	170490	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4449549	170490	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1Cl	10.1021/acsmedchemlett.9b00547
	146192964	174686	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4559891	174686	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	10519435	171445	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL446350	171445	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	15981509	141933	1	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
	CHEMBL387250	141933	1	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
	10856744	59995	11	None	6	2	Rat	6.5	pEC50	=	6.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.	ChEMBL	210	2	3	5	1.2	NCCc1ccc(O)c2nc(O)sc12	10.1021/jm00390a009
	CHEMBL17357	59995	11	None	6	2	Rat	6.5	pEC50	=	6.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.	ChEMBL	210	2	3	5	1.2	NCCc1ccc(O)c2nc(O)sc12	10.1021/jm00390a009
	85090330	181049	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4759814	181049	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	10506	2507	20	None	20	3	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	86290953	2507	20	None	20	3	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	CHEMBL3421729	2507	20	None	20	3	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	44320050	106804	0	None	-1	3	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL314459	106804	0	None	-1	3	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44320357	206376	0	None	54	2	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87734	206376	0	None	54	2	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	86293768	118789	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421836	118789	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	228	444	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	33	444	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6005	444	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL53	444	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	DB00714	444	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6604773	16226	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CC2	10.1016/j.bmc.2010.07.052
	CHEMBL1224528	16226	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CC2	10.1016/j.bmc.2010.07.052
	228	444	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	33	444	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6005	444	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL53	444	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	DB00714	444	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6852376	91570	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	CHEMBL1467585	91570	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	CHEMBL24077	91570	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	CHEMBL503958	91570	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	6603820	95745	19	None	-1	7	Rat	7.5	pEC50	=	7.5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	CHEMBL25856	95745	19	None	-1	7	Rat	7.5	pEC50	=	7.5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	145867041	174505	4	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL4555682	174505	4	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	44320327	163400	0	None	1	2	Rat	7.5	pEC50	=	7.5	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL419680	163400	0	None	1	2	Rat	7.5	pEC50	=	7.5	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	1242	3586	27	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assayAgonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	935	3586	27	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assayAgonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	CHEMBL286080	3586	27	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assayAgonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	137364067	191051	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	5	1	3	4.1	CCS(=N)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5187471	191051	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	5	1	3	4.1	CCS(=N)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	10709445	101336	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115377	101336	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL296993	101336	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	3033200	174503	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	CHEMBL4555547	174503	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	3033200	174503	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	CHEMBL4555547	174503	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	117720272	118788	3	None	-34	3	Mouse	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421730	118788	3	None	-34	3	Mouse	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	71722291	102433	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397385	102433	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040059	102433	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	146025708	173500	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4531083	173500	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	25142456	82377	2	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
	CHEMBL217299	82377	2	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
	146025708	173500	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4531083	173500	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44276404	99050	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL28054	99050	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	10802235	13227	0	None	-	1	Goldfish	5.5	pEC50	=	5.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL1191487	13227	0	None	-	1	Goldfish	5.5	pEC50	=	5.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL542593	13227	0	None	-	1	Goldfish	5.5	pEC50	=	5.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	10732044	84384	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114440	84384	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219804	84384	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	75201901	166401	19	None	95	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166401	19	None	95	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	44554474	106258	0	None	-301	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	3	1.7	C=CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099227	106258	0	None	-301	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	3	1.7	C=CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139043	106258	0	None	-301	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	3	1.7	C=CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	155519631	170381	0	None	-15	2	Rat	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to controlPositive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to control	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	CHEMBL4448100	170381	0	None	-15	2	Rat	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to controlPositive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to control	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	146025818	169738	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4438800	169738	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	44320076	206403	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87910	206403	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	681	1453	72	None	-77	15	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	940	1453	72	None	-77	15	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	947	1453	72	None	-77	15	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	CHEMBL59	1453	72	None	-77	15	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	DB00988	1453	72	None	-77	15	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	146025706	171600	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465592	171600	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	681	1453	72	None	-1380	15	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	940	1453	72	None	-1380	15	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	947	1453	72	None	-1380	15	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	CHEMBL59	1453	72	None	-1380	15	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	DB00988	1453	72	None	-1380	15	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	146025818	169738	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4438800	169738	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025706	171600	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465592	171600	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	44555137	104237	0	None	-28	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099232	104237	0	None	-28	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	155537335	172288	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	388	2	1	6	3.2	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1nccc2occc12	10.1021/acsmedchemlett.9b00050
	CHEMBL4475239	172288	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	388	2	1	6	3.2	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1nccc2occc12	10.1021/acsmedchemlett.9b00050
	681	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	940	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	947	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	CHEMBL59	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	DB00988	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	44320002	107014	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315535	107014	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44276556	99674	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL284644	99674	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	146025814	172755	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	172755	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	6852376	91570	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL1467585	91570	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL24077	91570	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL503958	91570	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	1242	3586	27	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	935	3586	27	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	CHEMBL286080	3586	27	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	146025814	172755	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	172755	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	10540201	100201	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL288536	100201	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
	681	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	940	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	947	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	CHEMBL59	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	DB00988	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	44320267	206189	0	None	-1	2	Rat	7.4	pEC50	=	7.4	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86576	206189	0	None	-1	2	Rat	7.4	pEC50	=	7.4	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44555138	104238	0	None	-117	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099233	104238	0	None	-117	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	49866139	16220	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CO2	10.1016/j.bmc.2010.07.052
	CHEMBL1224452	16220	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CO2	10.1016/j.bmc.2010.07.052
	1218	3589	30	None	-177	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	938	3589	30	None	-177	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	CHEMBL353335	3589	30	None	-177	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	44554987	104241	0	None	-114	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099239	104241	0	None	-114	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	13720694	12940	1	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	325	3	3	4	3.3	C=CCN1CCc2c(cc(O)c(O)c2C)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1189465	12940	1	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	325	3	3	4	3.3	C=CCN1CCc2c(cc(O)c(O)c2C)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL538785	12940	1	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	325	3	3	4	3.3	C=CCN1CCc2c(cc(O)c(O)c2C)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	13720690	13058	0	None	-1	2	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	311	3	3	4	3.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1190300	13058	0	None	-1	2	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	311	3	3	4	3.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL540575	13058	0	None	-1	2	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	311	3	3	4	3.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	155521159	170507	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	374	2	1	6	2.9	Cc1c(-c2ccc3c(c2)CCN3c2nccc3occc23)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	CHEMBL4449782	170507	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	374	2	1	6	2.9	Cc1c(-c2ccc3c(c2)CCN3c2nccc3occc23)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	6917970	3665	61	None	-2454	3	Rat	4.4	pEC50	=	4.4	Functional	Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activityAgonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	8370	3665	61	None	-2454	3	Rat	4.4	pEC50	=	4.4	Functional	Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activityAgonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	CHEMBL487387	3665	61	None	-2454	3	Rat	4.4	pEC50	=	4.4	Functional	Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activityAgonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	90134304	166490	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
	CHEMBL4278861	166490	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
	85090339	182281	0	None	-8	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
	CHEMBL4784143	182281	0	None	-8	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
	10518837	100445	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL290842	100445	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
	76284418	182294	0	None	-1	2	Human	7.4	pEC50	=	7.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4784295	182294	0	None	-1	2	Human	7.4	pEC50	=	7.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090320	182539	0	None	-10	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4787728	182539	0	None	-10	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	53494980	66464	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	3	3	2.7	Oc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1822918	66464	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	3	3	2.7	Oc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1852340	66464	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	3	3	2.7	Oc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	10830234	100349	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL289867	100349	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	681	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	940	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	947	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	CHEMBL59	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	DB00988	1453	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	86302251	172831	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	448	4	1	5	3.5	CN(Cc1nc2cc(Br)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	CHEMBL4514994	172831	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	448	4	1	5	3.5	CN(Cc1nc2cc(Br)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	155549423	173789	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	349	3	2	7	2.3	Cc1c(-c2ccc(Nc3nccc4occc34)nc2)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	CHEMBL4538358	173789	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	349	3	2	7	2.3	Cc1c(-c2ccc(Nc3nccc4occc34)nc2)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	44320327	163400	0	None	-1	2	Human	7.3	pEC50	=	7.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL419680	163400	0	None	-1	2	Human	7.3	pEC50	=	7.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	85470885	174636	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	438	4	1	5	3.8	CN(Cc1nc2cc(C(F)(F)F)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	CHEMBL4558647	174636	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	438	4	1	5	3.8	CN(Cc1nc2cc(C(F)(F)F)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	10081286	98746	2	None	1	2	Rat	5.3	pEC50	=	5.3	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effectDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effect	ChEMBL	192	2	3	3	0.4	NCCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	CHEMBL278188	98746	2	None	1	2	Rat	5.3	pEC50	=	5.3	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effectDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effect	ChEMBL	192	2	3	3	0.4	NCCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	10588326	158842	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL40950	158842	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
	10831251	163149	0	None	-	1	Goldfish	6.3	pEC50	=	6.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL41809	163149	0	None	-	1	Goldfish	6.3	pEC50	=	6.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	13864380	206409	1	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87958	206409	1	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
	13864381	208321	3	None	5	3	Human	6.3	pEC50	=	6.3	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL542683	208321	3	None	5	3	Human	6.3	pEC50	=	6.3	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL99361	208321	3	None	5	3	Human	6.3	pEC50	=	6.3	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	44331310	107339	1	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9502100
	CHEMBL317741	107339	1	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9502100
	168291403	191982	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	281	4	1	3	2.3	NS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5201584	191982	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	281	4	1	3	2.3	NS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	71563084	87542	0	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335736	87542	0	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	64638	106114	2	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313530	106114	2	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	6603703	208	10	None	-1	4	Rat	8.3	pEC50	=	8.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm9502100
	9637	208	10	None	-1	4	Rat	8.3	pEC50	=	8.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm9502100
	CHEMBL291143	208	10	None	-1	4	Rat	8.3	pEC50	=	8.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm9502100
	44320001	205993	0	None	3	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84983	205993	0	None	3	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	86764103	132411	13	None	2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL3697578	132411	13	None	2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	6453963	71510	9	None	10000	2	Human	8.3	pEC50	=	8.3	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmcl.2012.01.005
	CHEMBL1950491	71510	9	None	10000	2	Human	8.3	pEC50	=	8.3	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmcl.2012.01.005
	CHEMBL1962947	71510	9	None	10000	2	Human	8.3	pEC50	=	8.3	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmcl.2012.01.005
	130442590	169775	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4439333	169775	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	130442590	169775	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4439333	169775	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	44320026	206076	0	None	131	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85689	206076	0	None	131	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	117720272	118788	3	None	18	3	Human	8.2	pEC50	=	8.2	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421730	118788	3	None	18	3	Human	8.2	pEC50	=	8.2	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	10851849	169909	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL44414	169909	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	13720686	11528	0	None	3	2	Rat	7.3	pEC50	=	7.3	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	389	3	3	4	3.7	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1180562	11528	0	None	3	2	Rat	7.3	pEC50	=	7.3	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	389	3	3	4	3.7	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL131313	11528	0	None	3	2	Rat	7.3	pEC50	=	7.3	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	389	3	3	4	3.7	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	681	1453	72	None	-1380	15	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	940	1453	72	None	-1380	15	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	947	1453	72	None	-1380	15	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	CHEMBL59	1453	72	None	-1380	15	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	DB00988	1453	72	None	-1380	15	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	146025816	169954	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4442011	169954	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	146025816	169954	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4442011	169954	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	9796958	146553	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115374	146553	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL39230	146553	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL544814	146553	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	228	444	28	None	-14	20	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	33	444	28	None	-14	20	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	6005	444	28	None	-14	20	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	CHEMBL53	444	28	None	-14	20	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	DB00714	444	28	None	-14	20	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	44320053	205750	0	None	-3	2	Rat	7.3	pEC50	=	7.3	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL82899	205750	0	None	-3	2	Rat	7.3	pEC50	=	7.3	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	146025720	172924	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4517022	172924	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025720	172924	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4517022	172924	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025700	175348	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4574838	175348	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	146192953	171586	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1ccc(F)cc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4465386	171586	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1ccc(F)cc1Cl	10.1021/acsmedchemlett.9b00547
	145992269	166929	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4287192	166929	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
	146025700	175348	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4574838	175348	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	85090335	181090	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
	CHEMBL4760355	181090	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
	6852376	91570	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1467585	91570	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	CHEMBL24077	91570	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	CHEMBL503958	91570	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	145867041	174505	4	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL4555682	174505	4	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	1153	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	12668023	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	30026874	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	30026875	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	3341	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	6603851	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	933	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	939	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	985	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	CHEMBL1160786	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	CHEMBL1161520	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	CHEMBL588	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	DB00800	1615	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	53494976	66570	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	283	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3OC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1822919	66570	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	283	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3OC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1852625	66570	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	283	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3OC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	155560177	174906	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	378	3	1	6	2.7	Cc1nc2c(c(Oc3ccc(-c4c(C)c(=O)[nH]c(=O)n4C)c(C)c3)n1)CCC2	10.1021/acsmedchemlett.9b00050
	CHEMBL4565185	174906	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	378	3	1	6	2.7	Cc1nc2c(c(Oc3ccc(-c4c(C)c(=O)[nH]c(=O)n4C)c(C)c3)n1)CCC2	10.1021/acsmedchemlett.9b00050
	53494978	66472	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	299	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3ccccc3SC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1822920	66472	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	299	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3ccccc3SC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1852349	66472	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	299	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3ccccc3SC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	44320129	167870	0	None	56	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL431220	167870	0	None	56	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	44319976	106936	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
	CHEMBL315005	106936	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
	44320378	206040	0	None	63	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85409	206040	0	None	63	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10015860	99249	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL281932	99249	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	12170	3879	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	10.1021/acs.jmedchem.2c00949
	137364063	3879	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	10.1021/acs.jmedchem.2c00949
	CHEMBL5172089	3879	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	10.1021/acs.jmedchem.2c00949
	146025699	170463	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4449153	170463	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025710	170092	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4443737	170092	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025699	170463	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4449153	170463	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	155534541	171949	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	380	4	2	6	2.5	CC(=O)Nc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	10.1021/acsmedchemlett.9b00050
	CHEMBL4470808	171949	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	380	4	2	6	2.5	CC(=O)Nc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	10.1021/acsmedchemlett.9b00050
	146025710	170092	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4443737	170092	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	10506	2507	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	86290953	2507	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	CHEMBL3421729	2507	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	44276405	100081	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
	CHEMBL287513	100081	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
	130442514	166508	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4279267	166508	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
	10666423	162278	0	None	-	1	Goldfish	6.2	pEC50	=	6.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	363	1	3	4	4.7	Cc1cccc(-c2cc3c(s2)CN[C@H]2CCc4cc(O)c(O)cc4[C@H]32)c1	10.1021/jm970038v
	CHEMBL416435	162278	0	None	-	1	Goldfish	6.2	pEC50	=	6.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	363	1	3	4	4.7	Cc1cccc(-c2cc3c(s2)CN[C@H]2CCc4cc(O)c(O)cc4[C@H]32)c1	10.1021/jm970038v
	146025719	171183	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4459395	171183	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025719	171183	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4459395	171183	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44319915	205942	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84557	205942	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	146025726	170743	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4452764	170743	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025823	169553	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	CHEMBL4435882	169553	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	1242	3586	27	None	1	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 minsAgonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2019.04.014
	935	3586	27	None	1	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 minsAgonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2019.04.014
	CHEMBL286080	3586	27	None	1	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 minsAgonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2019.04.014
	146025823	169553	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	CHEMBL4435882	169553	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	146025726	170743	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4452764	170743	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	44320123	107056	0	None	4	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL315849	107056	0	None	4	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	15696487	163775	1	None	97	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL420604	163775	1	None	97	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10758745	100405	0	None	-	1	Goldfish	7.2	pEC50	=	7.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115373	100405	0	None	-	1	Goldfish	7.2	pEC50	=	7.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL290438	100405	0	None	-	1	Goldfish	7.2	pEC50	=	7.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	14809027	107002	0	None	-3	3	Rat	8.2	pEC50	=	8.2	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315468	107002	0	None	-3	3	Rat	8.2	pEC50	=	8.2	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	6603820	95745	19	None	1	7	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2011.07.057
	CHEMBL25856	95745	19	None	1	7	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2011.07.057
	146025728	175989	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4589664	175989	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025728	175989	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4589664	175989	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	6604005	157093	2	None	1	4	Rat	6.2	pEC50	=	6.2	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm9502100
	CHEMBL407489	157093	2	None	1	4	Rat	6.2	pEC50	=	6.2	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm9502100
	133642	171927	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL4470553	171927	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	133642	171927	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL4470553	171927	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	44554986	106257	0	None	-35	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099236	106257	0	None	-35	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139041	106257	0	None	-35	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	71722301	102446	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	CHEMBL3040157	102446	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	CHEMBL3216146	102446	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	130442508	171059	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	CHEMBL4457399	171059	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	71563082	87252	0	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2331599	87252	0	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	86293768	118789	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	CHEMBL3421836	118789	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	10664137	162731	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL417164	162731	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	130442508	171059	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	CHEMBL4457399	171059	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	146025725	171525	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4464545	171525	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025725	171525	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4464545	171525	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	71722295	102440	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397381	102440	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040115	102440	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	10546132	161231	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL41196	161231	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	146025711	173008	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4518891	173008	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025711	173008	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4518891	173008	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	71562964	87546	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335740	87546	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	6603703	208	10	None	-2	4	Goldfish	8.1	pEC50	=	8.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	9637	208	10	None	-2	4	Goldfish	8.1	pEC50	=	8.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	CHEMBL291143	208	10	None	-2	4	Goldfish	8.1	pEC50	=	8.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	64638	106114	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313530	106114	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44276551	97347	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL26965	97347	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	44276552	99852	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL285924	99852	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	10497993	168450	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL43514	168450	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
	44276572	96619	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL26365	96619	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	75201961	169606	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
	CHEMBL4437012	169606	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
	146192955	171502	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	409	4	1	4	3.8	C[C@H]1c2cccc(-c3cnn(C)c3)c2C[C@H](CO)N1C(=O)Cc1ccccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4464215	171502	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	409	4	1	4	3.8	C[C@H]1c2cccc(-c3cnn(C)c3)c2C[C@H](CO)N1C(=O)Cc1ccccc1Cl	10.1021/acsmedchemlett.9b00547
	10519436	11194	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL1178784	11194	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL41238	11194	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	118445551	167291	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
	CHEMBL4294009	167291	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
	13851595	174481	2	None	-489	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	2	3.0	CCCN1CCC[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3098131	174481	2	None	-489	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	2	3.0	CCCN1CCC[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL455497	174481	2	None	-489	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	2	3.0	CCCN1CCC[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	85090338	180737	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4756163	180737	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	14809026	205764	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL83080	205764	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
	14809026	205764	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL83080	205764	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10684714	100282	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115372	100282	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL289283	100282	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	146025817	175993	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4589737	175993	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025817	175993	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4589737	175993	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	6603820	95745	19	None	-6	7	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL25856	95745	19	None	-6	7	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
	10592479	100237	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL288846	100237	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	146025705	170590	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4450916	170590	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44554982	104235	0	None	-58	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099230	104235	0	None	-58	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	44320257	206152	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86325	206152	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	146025705	170590	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4450916	170590	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	90142280	167272	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	CHEMBL4293757	167272	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	9841398	99491	4	None	2	3	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL28338	99491	4	None	2	3	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	10546131	100381	0	None	-	1	Goldfish	7.0	pEC50	=	7.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL290149	100381	0	None	-	1	Goldfish	7.0	pEC50	=	7.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
	6852376	91570	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL1467585	91570	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL24077	91570	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL503958	91570	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	155558060	174660	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	414	4	1	6	3.0	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1ncccc1OC(F)F	10.1021/acsmedchemlett.9b00050
	CHEMBL4559240	174660	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	414	4	1	6	3.0	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1ncccc1OC(F)F	10.1021/acsmedchemlett.9b00050
	146025822	173767	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4537900	173767	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025822	173767	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4537900	173767	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	107930	1517	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	3304	1517	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	CHEMBL298406	1517	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	DB12273	1517	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	3036864	202731	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL1256645	202731	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL1814790	202731	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL62	202731	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	155561845	175694	0	None	-5	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL4582377	175694	0	None	-5	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	15061351	86450	0	None	-2	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	367	2	0	6	3.0	COc1ccc2c(c1OC(C)=O)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL2314734	86450	0	None	-2	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	367	2	0	6	3.0	COc1ccc2c(c1OC(C)=O)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	71453989	83499	0	None	-1	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	298	0	0	4	4.0	Cn1c2cnc1OCC/C=C\CCCCOc1ccccc1-2	10.1021/jm1012374
	CHEMBL2203622	83499	0	None	-1	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	298	0	0	4	4.0	Cn1c2cnc1OCC/C=C\CCCCOc1ccccc1-2	10.1021/jm1012374
	70682088	76039	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057446	76039	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	46931072	202022	1	None	-1	2	Human	5.9	pIC50	=	5.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL608530	202022	1	None	-1	2	Human	5.9	pIC50	=	5.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	3246545	202451	1	None	-3	3	Human	6.9	pIC50	=	6.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL1573438	202451	1	None	-3	3	Human	6.9	pIC50	=	6.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL611207	202451	1	None	-3	3	Human	6.9	pIC50	=	6.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	70690500	76044	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057455	76044	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	155538443	172358	0	None	-2	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL4476383	172358	0	None	-2	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	146025811	171737	0	None	-416	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	171737	0	None	-416	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	1353	1898	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	3559	1898	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	86	1898	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	CHEMBL54	1898	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	DB00502	1898	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	72301	186094	76	None	-3	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2019.04.014
	CHEMBL487182	186094	76	None	-3	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2019.04.014
	44299467	197533	0	None	-30	2	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	CHEMBL57029	197533	0	None	-30	2	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	3246443	37656	2	None	-16	3	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL1457510	37656	2	None	-16	3	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	44537919	198113	0	None	-60	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL574700	198113	0	None	-60	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	72699716	115163	0	None	-12	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344459	115163	0	None	-12	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	161665	172561	35	None	-28	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL448891	172561	35	None	-28	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	70690498	76038	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057445	76038	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	13869636	101678	0	None	-83	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	397	8	0	4	4.7	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1021/jm00393a037
	CHEMBL299471	101678	0	None	-83	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	397	8	0	4	4.7	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1021/jm00393a037
	44299213	100605	0	None	-77	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@@H]1C	10.1021/jm00393a037
	CHEMBL292006	100605	0	None	-77	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@@H]1C	10.1021/jm00393a037
	44299579	197696	0	None	-33	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	CHEMBL57140	197696	0	None	-33	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	18367	194920	30	None	-60	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	341	6	1	3	3.8	O=C(CCCN1CCC(O)(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	CHEMBL54206	194920	30	None	-60	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	341	6	1	3	3.8	O=C(CCCN1CCC(O)(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	3036864	202731	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	CHEMBL1256645	202731	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	CHEMBL1814790	202731	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	CHEMBL62	202731	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	3036864	202731	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	CHEMBL1256645	202731	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	CHEMBL1814790	202731	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	CHEMBL62	202731	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	44299566	196755	0	None	-67	2	Rat	5.5	pIC50	=	5.5	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@H]1C	10.1021/jm00393a037
	CHEMBL56547	196755	0	None	-67	2	Rat	5.5	pIC50	=	5.5	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@H]1C	10.1021/jm00393a037
	44537925	198721	0	None	-162	3	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL582945	198721	0	None	-162	3	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	129103318	167290	0	None	-39	6	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assayAntagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assay	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	CHEMBL4293999	167290	0	None	-39	6	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assayAntagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assay	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	228	444	28	None	-131	20	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	33	444	28	None	-131	20	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	6005	444	28	None	-131	20	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	CHEMBL53	444	28	None	-131	20	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	DB00714	444	28	None	-131	20	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	146025812	174867	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4564103	174867	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025812	174867	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4564103	174867	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	90899701	169711	0	None	-5	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	313	1	3	5	2.5	COc1ccc2c(c1O)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	CHEMBL4438471	169711	0	None	-5	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	313	1	3	5	2.5	COc1ccc2c(c1O)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	453215	86452	8	None	7	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)C1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2019.04.014
	CHEMBL2314745	86452	8	None	7	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)C1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2019.04.014
	3246545	202451	1	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL1573438	202451	1	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL611207	202451	1	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	146025813	175563	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	175563	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025813	175563	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	175563	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	3036864	202731	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL1256645	202731	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL1814790	202731	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL62	202731	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	1353	1898	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	3559	1898	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	86	1898	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	CHEMBL54	1898	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	DB00502	1898	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	3036864	202731	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1256645	202731	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1814790	202731	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL62	202731	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	3036864	202731	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1256645	202731	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1814790	202731	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL62	202731	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	72699817	115162	0	None	1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	CHEMBL3344458	115162	0	None	1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	5018	3523	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	943	3523	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	946	3523	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	CHEMBL13668	3523	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	12269810	86453	8	None	-15	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	327	2	2	5	2.8	COc1ccc2c(c1OC)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	CHEMBL2314747	86453	8	None	-15	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	327	2	2	5	2.8	COc1ccc2c(c1OC)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	24837531	174750	1	None	-4	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	311	2	1	4	3.1	COc1cc2c(cc1OC)C1Cc3ccc(O)cc3CN1CC2	10.1016/j.bmc.2019.04.014
	CHEMBL4561303	174750	1	None	-4	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	311	2	1	4	3.1	COc1cc2c(cc1OC)C1Cc3ccc(O)cc3CN1CC2	10.1016/j.bmc.2019.04.014
	9549058	173126	0	None	3	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.bmc.2019.04.014
	CHEMBL4521450	173126	0	None	3	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.bmc.2019.04.014
	146025814	172755	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	172755	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	155552483	174035	0	None	-6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	2	1	6	2.8	COc1cc2c(c(OC)c1O)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL4544045	174035	0	None	-6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	2	1	6	2.8	COc1cc2c(c(OC)c1O)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	146025814	172755	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	172755	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	13869644	197229	0	None	-109	2	Rat	5.1	pIC50	=	5.1	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	325	6	0	2	4.7	O=C(CCCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	CHEMBL56843	197229	0	None	-109	2	Rat	5.1	pIC50	=	5.1	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	325	6	0	2	4.7	O=C(CCCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	146025815	169755	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4439029	169755	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	146025815	169755	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4439029	169755	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	156017431	177753	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
	CHEMBL4643069	177753	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
	11681599	75144	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL203637	75144	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	133538	3592	24	None	-	1	Human	8.9	pKi	=	8.9	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	8443	3592	24	None	-	1	Human	8.9	pKi	=	8.9	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	CHEMBL574558	3592	24	None	-	1	Human	8.9	pKi	=	8.9	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	11558055	73123	1	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL1204122	73123	1	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL201170	73123	1	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	11573628	74670	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
	CHEMBL203047	74670	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
	9992499	73357	0	None	-	0	Human	6.0	pKi	=	6	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
	CHEMBL201483	73357	0	None	-	0	Human	6.0	pKi	=	6	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
	11716449	141190	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	CHEMBL382850	141190	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	10071501	9847	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	CHEMBL114228	9847	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	1242	3586	27	None	1	3	Human	6.7	pKi	=	6.7	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	935	3586	27	None	1	3	Human	6.7	pKi	=	6.7	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	CHEMBL286080	3586	27	None	1	3	Human	6.7	pKi	=	6.7	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	11716438	140857	1	None	-	0	Human	8.6	pKi	=	8.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
	CHEMBL382010	140857	1	None	-	0	Human	8.6	pKi	=	8.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
	16090814	81552	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL216258	81552	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	11566745	74665	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL1202298	74665	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL203029	74665	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	11558247	75393	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	CHEMBL204098	75393	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	11637457	73058	1	None	-	0	Human	6.7	pKi	=	6.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
	CHEMBL201093	73058	1	None	-	0	Human	6.7	pKi	=	6.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
	9952858	7522	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
	CHEMBL108764	7522	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
	44408818	140140	1	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
	CHEMBL380330	140140	1	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
	11573806	75387	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	CHEMBL204065	75387	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	10467946	48439	4	None	-	0	Human	8.5	pKi	=	8.5	Functional	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1016/j.ejmech.2022.114378
	CHEMBL155596	48439	4	None	-	0	Human	8.5	pKi	=	8.5	Functional	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1016/j.ejmech.2022.114378
	11623343	140817	1	None	-	0	Human	8.5	pKi	=	8.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL381936	140817	1	None	-	0	Human	8.5	pKi	=	8.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	11493746	141298	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL383451	141298	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
	16090821	81804	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
	CHEMBL216439	81804	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
	11718008	75262	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL203734	75262	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	137284323	184829	0	None	-	1	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	341	1	1	3	4.9	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CC1	10.1016/j.bmcl.2021.127911
	CHEMBL4852403	184829	0	None	-	1	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	341	1	1	3	4.9	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CC1	10.1016/j.bmcl.2021.127911
	11536995	139530	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL379662	139530	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	147230103	180129	0	None	-	2	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2021.127911
	CHEMBL4748915	180129	0	None	-	2	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2021.127911
	5249956	73366	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	CHEMBL201525	73366	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	135398737	955	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	38	955	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	722	955	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	CHEMBL42	955	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	DB00363	955	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	11500677	140823	1	None	-	0	Human	6.3	pKi	=	6.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL381946	140823	1	None	-	0	Human	6.3	pKi	=	6.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	147200197	185690	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	317	1	1	3	4.7	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	CHEMBL4865663	185690	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	317	1	1	3	4.7	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	11595240	140163	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	CHEMBL380464	140163	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	11558055	73123	1	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL1204122	73123	1	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL201170	73123	1	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	4350931	169289	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL441618	169289	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	4350931	169289	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
	CHEMBL441618	169289	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
	11522339	75223	1	None	-	0	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
	CHEMBL203689	75223	1	None	-	0	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
	5249952	73379	7	None	-	0	Human	6.1	pKi	=	6.1	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.4	CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1	10.1021/jm050846j
	CHEMBL201584	73379	7	None	-	0	Human	6.1	pKi	=	6.1	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.4	CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1	10.1021/jm050846j
	135409468	2022	69	None	-	5	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1016/j.bmcl.2021.127911
	333	2022	69	None	-	5	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1016/j.bmcl.2021.127911
	CHEMBL845	2022	69	None	-	5	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1016/j.bmcl.2021.127911
	164623328	185852	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	331	2	1	3	5.0	CCc1ccc2c(c1)C(C1=CCN(C)CC1)=Nc1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	CHEMBL4868181	185852	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	331	2	1	3	5.0	CCc1ccc2c(c1)C(C1=CCN(C)CC1)=Nc1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	149505732	186207	0	None	-	1	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	321	1	1	3	4.6	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2021.127911
	CHEMBL4873426	186207	0	None	-	1	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	321	1	1	3	4.6	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2021.127911
	1225	1459	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	1459	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	1459	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	1459	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	1459	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	133538	3592	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.	Guide to Pharmacology	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	25660762
	8443	3592	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.	Guide to Pharmacology	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	25660762
	CHEMBL574558	3592	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.	Guide to Pharmacology	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	25660762
	12170	3879	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Ligand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamineLigand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamine	Guide to Pharmacology	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	36044544
	137364063	3879	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Ligand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamineLigand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamine	Guide to Pharmacology	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	36044544
	CHEMBL5172089	3879	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Ligand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamineLigand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamine	Guide to Pharmacology	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	36044544
	10506	2507	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	86290953	2507	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	CHEMBL3421729	2507	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	10506	2507	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	86290953	2507	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	CHEMBL3421729	2507	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	122324	205	22	None	-4	4	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	6077	205	22	None	-4	4	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	CHEMBL86931	205	22	None	-4	4	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	11938	2396	7	None	11	4	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	35175768
	146192952	2396	7	None	11	4	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	35175768
	CHEMBL4468760	2396	7	None	11	4	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	35175768
	100	3776	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3294	1993	111	None	-56	45	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	1993	111	None	-56	45	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	1993	111	None	-56	45	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	1993	111	None	-56	45	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	1993	111	None	-56	45	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	103	4122	61	None	-28	54	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4122	61	None	-28	54	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4122	61	None	-28	54	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4122	61	None	-28	54	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4122	61	None	-28	54	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	46780481	107504	20	None	-29	54	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107504	20	None	-29	54	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107504	20	None	-29	54	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107504	20	None	-29	54	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	17676	7040	29	None	-	3	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7040	29	None	-	3	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7040	29	None	-	3	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2105	3032	37	None	-537	33	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3032	37	None	-537	33	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3032	37	None	-537	33	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3032	37	None	-537	33	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3032	37	None	-537	33	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL508338	188942	0	None	-	6	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	6237	86775	46	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	518	3	1	3	5.1	CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL232201	86775	46	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	518	3	1	3	5.1	CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1	10.1038/s41467-023-40064-9
	2237	3140	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
	3634	3140	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
	4887	3140	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
	CHEMBL21333	3140	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
	DB01411	3140	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
	60663	175645	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1421212	175645	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1534525	175645	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL45816	175645	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	1613	2333	53	None	-5	45	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2333	53	None	-5	45	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2333	53	None	-5	45	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2333	53	None	-5	45	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2333	53	None	-5	45	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2993	114666	24	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL121663	114666	24	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL333826	114666	24	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	7099	195499	59	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
	CHEMBL55400	195499	59	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
	4151	3580	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	493	3580	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	5312125	3580	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	CHEMBL24778	3580	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	DB06207	3580	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	2284	3160	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3160	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3160	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3160	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3160	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	1830	2572	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2572	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2572	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2572	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2572	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	2520	203985	70	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	203985	70	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	203985	70	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	2865	4112	73	None	-114	54	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4112	73	None	-114	54	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4112	73	None	-114	54	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4112	73	None	-114	54	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4112	73	None	-114	54	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	5354	155632	21	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL404849	155632	21	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
	82146	4498	113	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
	CHEMBL1023	4498	113	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
	27901	78178	22	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2105458	78178	22	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	7019	167952	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL1308088	167952	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL43184	167952	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	133	2479	52	None	-30	43	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	1723	2479	52	None	-30	43	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	28693	2479	52	None	-30	43	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	CHEMBL19215	2479	52	None	-30	43	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	DB13520	2479	52	None	-30	43	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	213046	2370	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2370	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2370	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2370	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2370	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	1577	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	164512405	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	2537	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	5355	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	5501	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	643497	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	688272	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	958	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	960	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL196677	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL26	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL267044	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	DB00391	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	DB16021	3677	110	None	-389	26	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	3652	4066	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	4066	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	4066	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	4066	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	4066	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	72287	61031	38	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1764	61031	38	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	237	204842	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL546257	204842	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL554190	204842	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL7568	204842	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	1027	1563	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	3241	1563	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	7176	1563	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL1106	1563	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB00751	1563	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	3055	1421	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	313	1421	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	7163	1421	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL936	1421	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	DB01231	1421	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	213	3824	55	None	-12	44	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3824	55	None	-12	44	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3824	55	None	-12	44	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3824	55	None	-12	44	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3824	55	None	-12	44	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2337	3232	77	None	-53	63	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-53	63	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-53	63	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-53	63	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-53	63	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	2406	100376	89	None	-	12	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
	CHEMBL290106	100376	89	None	-	12	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
	214	3831	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3831	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3831	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3831	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3831	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3831	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	9417	133487	54	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL1524185	133487	54	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL370753	133487	54	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	47979	78181	59	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2105581	78181	59	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	9429	202110	58	None	-	5	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	202110	58	None	-	5	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	213046	2370	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2370	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2370	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2370	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2370	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	60860	205616	30	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
	CHEMBL1615777	205616	30	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
	CHEMBL818	205616	30	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
	2749	343	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	5574	343	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7237	343	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL829	343	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01246	343	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	26987	946	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	946	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	946	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	946	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	946	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	3166	169396	23	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL442444	169396	23	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	135398745	2893	112	None	-26	66	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2893	112	None	-26	66	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2893	112	None	-26	66	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2893	112	None	-26	66	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	2398	951	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	951	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	951	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	951	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	951	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	9419	35892	35	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1442422	35892	35	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	6726	1269	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7151	1269	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	749	1269	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL648	1269	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB01176	1269	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	16960	14455	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1201287	14455	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	5584	203188	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL644	203188	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	9853053	120493	74	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL354541	120493	74	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	1765	3788	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
	4184	3788	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
	9871419	3788	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
	CHEMBL398435	3788	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
	DB08816	3788	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
	54454	5226	88	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5226	88	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	12488	1644	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	941361	1644	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	CHEMBL30008	1644	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	DB04841	1644	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	68802	110008	37	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	226	0	1	2	2.9	Cc1ccc2c(c1)c1c3n2CCNC3CCC1	10.1038/s41467-023-40064-9
	CHEMBL32350	110008	37	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	226	0	1	2	2.9	Cc1ccc2c(c1)c1c3n2CCNC3CCC1	10.1038/s41467-023-40064-9
	49843517	78265	41	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2107831	78265	41	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
	3606	203465	60	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL6615	203465	60	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	135	2515	43	None	-91	58	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2515	43	None	-91	58	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2515	43	None	-91	58	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2515	43	None	-91	58	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2515	43	None	-91	58	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	10219	188772	37	None	-	5	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	CHEMBL493439	188772	37	None	-	5	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	CHEMBL50588	188772	37	None	-	5	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	134	2497	24	None	-263	68	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2497	24	None	-263	68	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2497	24	None	-263	68	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2497	24	None	-263	68	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2497	24	None	-263	68	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1890	2739	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2739	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2739	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2739	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2739	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	5489013	57375	32	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
	CHEMBL1651913	57375	32	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
	115358	101535	38	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	463	9	2	6	5.9	COc1cc(C)c2c(Oc3cccc(C(F)(F)F)c3)c(OC)cc(NC(C)CCCN)c2n1	10.1038/s41467-023-40064-9
	CHEMBL298470	101535	38	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	463	9	2	6	5.9	COc1cc(C)c2c(Oc3cccc(C(F)(F)F)c3)c(OC)cc(NC(C)CCCN)c2n1	10.1038/s41467-023-40064-9
	1577	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	164512405	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	2537	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	5355	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	5501	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	643497	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	688272	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	958	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	960	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL196677	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL26	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL267044	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	DB00391	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	DB16021	3677	110	None	-389	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	2162	41484	100	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41484	100	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL508338	188942	0	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	5568	197477	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	66069	197477	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	CHEMBL1201102	197477	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	CHEMBL570	197477	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	71277	84510	27	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	789	9	4	15	2.7	CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C	10.1038/s41467-023-40064-9
	CHEMBL2220427	84510	27	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	789	9	4	15	2.7	CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C	10.1038/s41467-023-40064-9
	2286	3161	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3161	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3161	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3161	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3161	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	22323	15267	32	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15267	32	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15267	32	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2146	3078	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	3078	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	3078	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	3078	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	3078	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6834	205529	45	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL811	205529	45	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	191	402	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	402	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	402	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	402	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	402	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	1909	2803	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	2559	2803	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	4474	2803	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	CHEMBL1484	2803	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	CHEMBL3302409	2803	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	DB00622	2803	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	212	3777	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3777	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3777	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3777	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3777	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2335	11816	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11816	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11816	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11816	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	25025298	78122	39	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
	CHEMBL2103855	78122	39	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
	103	4122	61	None	-28	54	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4122	61	None	-28	54	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4122	61	None	-28	54	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4122	61	None	-28	54	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4122	61	None	-28	54	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	3601	14471	9	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1201349	14471	9	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
	2762	3834	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	5587	3834	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	7318	3834	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL1241	3834	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	DB00792	3834	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	5583	13012	51	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL119	13012	51	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
	22530	56100	58	None	-	3	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1600878	56100	58	None	-	3	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1625607	56100	58	None	-	3	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	62867	3107	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	7557	3107	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL398880	3107	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01621	3107	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	9822750	78380	65	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL2111097	78380	65	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
	25151352	140581	67	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	CHEMBL3813873	140581	67	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	1547484	937	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	654	937	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	9072	937	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL43064	937	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00568	937	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4167	14468	43	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1201342	14468	43	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	40973	46005	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
	CHEMBL1533	46005	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
	4418	34192	85	None	-	7	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34192	85	None	-	7	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	3344	198295	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
	CHEMBL576127	198295	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
	242	469	124	None	-281	52	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-281	52	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-281	52	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-281	52	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-281	52	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	9601226	102373	7	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	563	14	1	6	6.1	CCC(=O)O[C@@H](O[P@](=O)(CCCCc1ccccc1)CC(=O)N1C[C@H](C2CCCCC2)C[C@H]1C(=O)O)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL3039598	102373	7	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	563	14	1	6	6.1	CCC(=O)O[C@@H](O[P@](=O)(CCCCc1ccccc1)CC(=O)N1C[C@H](C2CCCCC2)C[C@H]1C(=O)O)C(C)C	10.1038/s41467-023-40064-9
	138106885	166887	75	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	36314	166887	75	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	CHEMBL428647	166887	75	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	3336	94972	30	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1405922	94972	30	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL254832	94972	30	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4601	206724	35	None	-	17	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201023	206724	35	None	-	17	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL900	206724	35	None	-	17	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	102	4096	48	None	-25118	50	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4096	48	None	-25118	50	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4096	48	None	-25118	50	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4096	48	None	-25118	50	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4096	48	None	-25118	50	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	25295	13588	37	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1194287	13588	37	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	9417	133487	54	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL1524185	133487	54	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL370753	133487	54	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	11057	176125	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	3468	176125	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL459265	176125	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL64894	176125	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	2585	800	103	None	-112	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	800	103	None	-112	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	800	103	None	-112	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	800	103	None	-112	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	800	103	None	-112	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	3117	207818	103	None	-2	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	10.1038/s41467-023-40064-9
	CHEMBL964	207818	103	None	-2	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	10.1038/s41467-023-40064-9
	1599	2326	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	3955	2326	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7215	2326	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL841	2326	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00836	2326	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135398737	955	93	None	-44	92	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-44	92	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-44	92	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-44	92	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-44	92	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	16564	204972	32	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
	CHEMBL76725	204972	32	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
	4417	55532	54	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL1439099	55532	54	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL1620794	55532	54	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL4744444	214011	32	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@@H]([C@H](C)CC(=O)O)C(=O)N[C@@H](CC(=O)c2ccccc2N)C(=O)O[C@@H]1C	10.1038/s41467-023-40064-9
	31101	726	40	None	-436	36	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-436	36	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-436	36	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-436	36	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-436	36	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	1613	2333	53	None	-5	45	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2333	53	None	-5	45	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2333	53	None	-5	45	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2333	53	None	-5	45	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2333	53	None	-5	45	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3627	44099	18	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1515447	44099	18	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	93154	5404	29	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL107360	5404	29	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
	16222096	80454	67	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	CHEMBL2146883	80454	67	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	1227	2472	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	2331	2472	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	3957	2472	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	4992	2472	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL511	2472	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	DB06691	2472	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	5022	1638	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	6918248	1638	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	8182	1638	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL231068	1638	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	DB04908	1638	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	6077	150674	31	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL39560	150674	31	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	3561	19045	39	None	-1	11	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1289	19045	39	None	-1	11	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
	441383	20301	57	None	-12	17	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1306	20301	57	None	-12	17	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	259329	60474	31	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	519	7	2	4	5.3	C[C@]12CC[C@@H]3c4ccc(OC(=O)N(CCCl)CCCl)cc4CC[C@H]3[C@@H]1CC[C@@H]2OP(=O)(O)O	10.1038/s41467-023-40064-9
	CHEMBL1756	60474	31	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	519	7	2	4	5.3	C[C@]12CC[C@@H]3c4ccc(OC(=O)N(CCCl)CCCl)cc4CC[C@H]3[C@@H]1CC[C@@H]2OP(=O)(O)O	10.1038/s41467-023-40064-9
	2181	3106	46	None	-	35	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	4830	3106	46	None	-	35	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	92	3106	46	None	-	35	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	CHEMBL440294	3106	46	None	-	35	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	DB09286	3106	46	None	-	35	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	CHEMBL5291995	194513	0	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	4098	32475	30	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1255739	32475	30	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1411979	32475	30	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	1153	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	12668023	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026874	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026875	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	3341	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	6603851	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	933	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	939	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	985	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1160786	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1161520	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL588	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	DB00800	1615	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	4485	69350	118	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL193	69350	118	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	1190	879	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	25074887	879	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	583	879	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	CHEMBL1200490	879	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	DB00050	879	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	48041	107054	46	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
	CHEMBL315838	107054	46	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
	40	1535	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	77993	1535	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	995	1535	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1510	1535	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	DB00216	1535	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	37464	19189	26	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1290	19189	26	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
	3584	3748	64	None	-	14	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	5401	3748	64	None	-	14	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	7302	3748	64	None	-	14	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL611	3748	64	None	-	14	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	DB01162	3748	64	None	-	14	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	3158	56237	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	2237	3140	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
	3634	3140	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
	4887	3140	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
	CHEMBL21333	3140	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
	DB01411	3140	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
	25025298	78122	39	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
	CHEMBL2103855	78122	39	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
	228	444	28	None	-35	24	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	444	28	None	-35	24	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	444	28	None	-35	24	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	444	28	None	-35	24	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	444	28	None	-35	24	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	9571107	167495	33	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
	CHEMBL430	167495	33	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
	2600	3750	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3750	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3750	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3750	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3750	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	150311	9780	102	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	409	6	2	3	4.9	O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL1138	9780	102	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	409	6	2	3	4.9	O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1	10.1038/s41467-023-40064-9
	2444	14446	26	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201245	14446	26	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	2799	39764	55	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	364	4	1	1	7.0	CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1476605	39764	55	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	364	4	1	1	7.0	CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1	10.1038/s41467-023-40064-9
	11154555	797	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	5037	797	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	7671	797	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL2028019	797	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL3085826	797	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB06016	797	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	11976	917	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	667467	917	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	CHEMBL908	917	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	DB01239	917	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	2865	4112	73	None	-114	54	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4112	73	None	-114	54	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4112	73	None	-114	54	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4112	73	None	-114	54	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4112	73	None	-114	54	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL4743867	214010	14	None	-	0	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	3158	56237	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	277	1289	62	None	-47	46	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	2913	1289	62	None	-47	46	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	765	1289	62	None	-47	46	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL516	1289	62	None	-47	46	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB00434	1289	62	None	-47	46	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	1427	2000	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2000	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2000	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2000	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2000	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	15387	45792	55	None	-	24	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1531134	45792	55	None	-	24	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	2286	3161	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3161	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3161	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3161	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3161	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	124087	1377	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1377	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1377	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1377	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1377	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	2105	3032	37	None	-537	33	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3032	37	None	-537	33	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3032	37	None	-537	33	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3032	37	None	-537	33	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3032	37	None	-537	33	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	9571107	167495	33	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
	CHEMBL430	167495	33	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
	3678	94763	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL253371	94763	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	2335	11816	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11816	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11816	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11816	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	54758501	139042	58	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
	CHEMBL3786343	139042	58	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
	71109	78177	10	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
	CHEMBL2105453	78177	10	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
	1971	2846	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2846	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2846	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2846	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2846	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2389	3306	118	None	-489	68	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3306	118	None	-489	68	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3306	118	None	-489	68	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3306	118	None	-489	68	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3306	118	None	-489	68	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2771	194994	74	None	-120	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	194994	74	None	-120	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	194994	74	None	-120	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	34040	28054	72	None	-	1	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	CHEMBL1372950	28054	72	None	-	1	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	2865	4112	73	None	-114	54	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4112	73	None	-114	54	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4112	73	None	-114	54	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4112	73	None	-114	54	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4112	73	None	-114	54	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	2601	3751	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3751	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3751	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3751	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3751	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	12555	17929	53	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL12610	17929	53	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
	11167602	70431	116	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1946170	70431	116	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
	1548955	88552	20	None	-	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	2800	88552	20	None	-	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL2355051	88552	20	None	-	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	1212	1649	50	None	-51	66	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1649	50	None	-51	66	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1649	50	None	-51	66	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1649	50	None	-51	66	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1649	50	None	-51	66	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	25102847	78192	93	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78192	93	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	1588	2311	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	28864	2311	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	43	2311	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL157138	2311	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB00589	2311	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	135398737	955	93	None	-44	92	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-44	92	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-44	92	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-44	92	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-44	92	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	180	400	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	193962	103766	106	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
	CHEMBL308954	103766	106	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
	1353	1898	93	None	-38	86	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-38	86	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-38	86	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-38	86	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-38	86	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3157	1458	71	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1458	71	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1458	71	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1458	71	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1458	71	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	5328940	100188	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL288441	100188	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	135398737	955	93	None	-44	92	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-44	92	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-44	92	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-44	92	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-44	92	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	65772	60373	8	None	-	6	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL174984	60373	8	None	-	6	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1038/s41467-023-40064-9
	5329102	194703	86	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194703	86	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	135	2515	43	None	-91	58	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2515	43	None	-91	58	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2515	43	None	-91	58	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2515	43	None	-91	58	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2515	43	None	-91	58	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	2683	102861	25	None	-	16	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL305906	102861	25	None	-	16	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL334255	102861	25	None	-	16	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	16362	3103	71	None	-52480	30	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3103	71	None	-52480	30	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3103	71	None	-52480	30	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3103	71	None	-52480	30	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3103	71	None	-52480	30	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	5351322	94762	38	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL25336	94762	38	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	65863	14433	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1201196	14433	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
	115368	3034	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	2112	3034	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	7556	3034	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1472975	3034	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	DB08922	3034	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	208898	66169	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	CHEMBL184412	66169	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	1086	1577	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	3290	1577	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	7181	1577	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	CHEMBL1206	1577	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	DB00392	1577	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	2337	3232	77	None	-53	63	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-53	63	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-53	63	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-53	63	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-53	63	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	2726	916	68	None	-36	73	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	916	68	None	-36	73	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	916	68	None	-36	73	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	916	68	None	-36	73	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	916	68	None	-36	73	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	448537	160226	89	None	-28	25	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160226	89	None	-28	25	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	10531	1408	21	None	-218	24	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1408	21	None	-218	24	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1408	21	None	-218	24	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1408	21	None	-218	24	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1408	21	None	-218	24	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	4822	45002	47	None	-	1	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL152408	45002	47	None	-	1	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
	2407	3347	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3347	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3347	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3347	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3347	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	49843517	78265	41	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2107831	78265	41	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
	25151352	140581	67	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	CHEMBL3813873	140581	67	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	11167602	70431	116	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1946170	70431	116	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
	10071196	3102	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	5142	3102	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	8423	3102	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	CHEMBL2111101	3102	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	DB05316	3102	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	71897	78219	19	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
	CHEMBL2106537	78219	19	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
	2805	161866	38	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL415087	161866	38	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	114948	60267	14	None	-	3	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL1743263	60267	14	None	-	3	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	16351	102703	47	None	-	6	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102703	47	None	-	6	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	123879	3262	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
	1910	3262	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
	1911	3262	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
	2354	3262	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
	CHEMBL361812	3262	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
	DB13036	3262	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
	10180	98841	47	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	CHEMBL279014	98841	47	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	3598	187797	76	None	-	7	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL496	187797	76	None	-	7	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
	37	775	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	775	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	775	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	775	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	775	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	1524	2168	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	197	2168	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	3822	2168	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	88	2168	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL51	2168	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB12465	2168	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	242	469	124	None	-281	52	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-281	52	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-281	52	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-281	52	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-281	52	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	21855	84217	42	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL22108	84217	42	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	5353853	17954	47	None	-19	15	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9556529	17954	47	None	-19	15	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1262	17954	47	None	-19	15	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2389	3306	118	None	-489	68	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3306	118	None	-489	68	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3306	118	None	-489	68	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3306	118	None	-489	68	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3306	118	None	-489	68	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	6077	150674	31	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL39560	150674	31	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	3294	1993	111	None	-56	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	1993	111	None	-56	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	1993	111	None	-56	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	1993	111	None	-56	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	1993	111	None	-56	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	2710	84279	31	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL22150	84279	31	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	43082	60253	37	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1742452	60253	37	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	98941	46920	17	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL154126	46920	17	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	2107	3033	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	4747	3033	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	9216	3033	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL251940	3033	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB01608	3033	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5440	28693	37	None	-1	9	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28693	37	None	-1	9	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	104903	56314	17	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1630578	56314	17	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
	1712	2475	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4078	2475	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	7227	2475	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	CHEMBL1088	2475	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	DB00933	2475	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	2771	194994	74	None	-120	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	194994	74	None	-120	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	194994	74	None	-120	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	2446	154629	57	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	7	2	4	2.1	CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL399510	154629	57	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	7	2	4	2.1	CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC	10.1038/s41467-023-40064-9
	681	1453	72	None	-154	39	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	940	1453	72	None	-154	39	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	947	1453	72	None	-154	39	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL59	1453	72	None	-154	39	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00988	1453	72	None	-154	39	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	3103	41628	49	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1492	41628	49	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	135398745	2893	112	None	-26	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2893	112	None	-26	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2893	112	None	-26	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2893	112	None	-26	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	212	3777	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3777	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3777	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3777	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3777	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	242	469	124	None	-281	52	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-281	52	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-281	52	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-281	52	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-281	52	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	3952	1875	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5353646	1875	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5443	1875	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5702063	1875	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	CHEMBL1331786	1875	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	CHEMBL420	1875	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	2389	3306	118	None	-489	68	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3306	118	None	-489	68	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3306	118	None	-489	68	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3306	118	None	-489	68	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3306	118	None	-489	68	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	129893322	28587	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	4923	28587	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353897	28587	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	6178111	28587	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1377	28587	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	2337	3232	77	None	-53	63	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-53	63	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-53	63	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-53	63	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-53	63	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	1209	1645	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1645	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1645	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1645	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1645	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	5591	157507	90	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157507	90	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	3280	48419	28	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
	CHEMBL1555736	48419	28	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
	4209	3141	75	None	-	34	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3141	75	None	-	34	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3141	75	None	-	34	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3141	75	None	-	34	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3141	75	None	-	34	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3141	75	None	-	34	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	3053	205111	95	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL780	205111	95	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	5205	78158	58	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL2104895	78158	58	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL1630575	56313	0	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
	443869	78112	45	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL2103761	78112	45	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	1353	1898	93	None	-38	86	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-38	86	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-38	86	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-38	86	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-38	86	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2600	3750	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3750	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3750	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3750	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3750	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	180	400	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2580	78366	18	None	-	2	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL2110775	78366	18	None	-	2	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
	4756	16617	50	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	CHEMBL1201022	16617	50	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	CHEMBL1242	16617	50	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	1153	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	12668023	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026874	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026875	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	3341	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	6603851	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	933	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	939	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	985	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1160786	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1161520	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL588	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	DB00800	1615	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	1353	1898	93	None	-38	86	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-38	86	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-38	86	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-38	86	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-38	86	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	3783	13973	23	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1197051	13973	23	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	6075	150084	42	None	-	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	CHEMBL395110	150084	42	None	-	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	4735	195092	96	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL361506	195092	96	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL55	195092	96	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	4034	55792	55	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55792	55	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	2247	504	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	146025821	169647	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4437552	169647	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025821	169647	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4437552	169647	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025817	175993	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4589737	175993	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025817	175993	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4589737	175993	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146192964	174686	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL4559891	174686	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	681	1453	72	None	-154	39	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
	940	1453	72	None	-154	39	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
	947	1453	72	None	-154	39	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
	CHEMBL59	1453	72	None	-154	39	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
	DB00988	1453	72	None	-154	39	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
	6852376	91570	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
	CHEMBL1467585	91570	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
	CHEMBL24077	91570	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
	CHEMBL503958	91570	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
	11938	2396	7	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	146192952	2396	7	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL4468760	2396	7	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	75201901	166401	19	None	-1	24	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166401	19	None	-1	24	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	130442471	176060	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4591207	176060	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	75201961	169606	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
	CHEMBL4437012	169606	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
	130442471	176060	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4591207	176060	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	75201901	166401	19	None	-1	24	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166401	19	None	-1	24	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	4901726	180775	9	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4756486	180775	9	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	12668019	10207	8	None	204	3	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
	CHEMBL1160787	10207	8	None	204	3	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
	6603820	95745	19	None	-4	13	Human	7.9	pEC50	=	7.9	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
	CHEMBL25856	95745	19	None	-4	13	Human	7.9	pEC50	=	7.9	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
	146025820	173198	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4523054	173198	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	681	1453	72	None	-154	39	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	940	1453	72	None	-154	39	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	947	1453	72	None	-154	39	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	CHEMBL59	1453	72	None	-154	39	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	DB00988	1453	72	None	-154	39	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	85090318	179421	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4740497	179421	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	146192966	175292	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acs.jmedchem.1c01887
	CHEMBL4573538	175292	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acs.jmedchem.1c01887
	85090319	180586	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4754602	180586	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090338	180737	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4756163	180737	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090320	182539	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4787728	182539	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090337	183257	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4796761	183257	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	11938	2396	7	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	146192952	2396	7	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL4468760	2396	7	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	85090325	179725	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4744261	179725	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090334	180601	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4754761	180601	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	132016545	173052	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	333	2	0	1	4.7	C[C@H]1c2ccccc2CCN1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL4519818	173052	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	333	2	0	1	4.7	C[C@H]1c2ccccc2CCN1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	9796958	146553	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
	CHEMBL2115374	146553	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
	CHEMBL39230	146553	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
	CHEMBL544814	146553	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
	130442473	167313	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4294397	167313	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442473	167313	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4294397	167313	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	85090335	181090	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
	CHEMBL4760355	181090	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
	85090330	181049	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4759814	181049	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	167715	2856	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	969	2856	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL225230	2856	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	24133757	171576	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	340	1	1	2	5.2	CC1c2ccsc2CCN1C(=O)Nc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL4465320	171576	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	340	1	1	2	5.2	CC1c2ccsc2CCN1C(=O)Nc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	167715	2856	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	969	2856	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL225230	2856	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	133642	171927	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL4470553	171927	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	133642	171927	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL4470553	171927	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	10742	3590	31	None	-2	8	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	1225	3590	31	None	-2	8	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL35354	3590	31	None	-2	8	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	10020353	13857	18	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL1196161	13857	18	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL556024	13857	18	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	85090328	181011	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4759339	181011	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	146025701	170547	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	CHEMBL4450338	170547	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	146025713	171587	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465393	171587	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025701	170547	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	CHEMBL4450338	170547	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	146025713	171587	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465393	171587	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	130442480	175246	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175246	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	130442480	175246	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175246	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	146025816	169954	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4442011	169954	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	1242	3586	27	None	-5	18	Human	6.6	pEC50	=	6.6	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	nan
	935	3586	27	None	-5	18	Human	6.6	pEC50	=	6.6	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	nan
	CHEMBL286080	3586	27	None	-5	18	Human	6.6	pEC50	=	6.6	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	nan
	146192967	191088	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	485	5	1	5	4.5	C[C@H]1c2cccc(-c3cnn(C4COC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL5187909	191088	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	485	5	1	5	4.5	C[C@H]1c2cccc(-c3cnn(C4COC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	146025816	169954	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4442011	169954	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	130442590	169775	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4439333	169775	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	130442590	169775	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4439333	169775	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	130442572	171884	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171884	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442572	171884	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171884	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	6603703	208	10	None	-1	5	Human	8.5	pEC50	=	8.5	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
	9637	208	10	None	-1	5	Human	8.5	pEC50	=	8.5	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
	CHEMBL291143	208	10	None	-1	5	Human	8.5	pEC50	=	8.5	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
	1153	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	12668023	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	30026874	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	30026875	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	3341	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	6603851	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	933	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	939	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	985	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1160786	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1161520	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL588	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	DB00800	1615	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	75201901	166401	19	None	-1	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
	CHEMBL4277264	166401	19	None	-1	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
	2030130	20947	16	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL1311333	20947	16	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090324	180668	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4755481	180668	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	76284418	182294	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4784295	182294	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	75202022	170786	2	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL4453318	170786	2	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	146025815	169755	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4439029	169755	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	1218	3589	30	None	-11	8	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	938	3589	30	None	-11	8	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	CHEMBL353335	3589	30	None	-11	8	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	146025815	169755	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4439029	169755	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	85090321	182789	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4790909	182789	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090323	181898	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4779641	181898	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
	146266	100670	8	None	-2	4	Human	7.4	pEC50	=	7.4	Binding	Antagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assayAntagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
	CHEMBL292418	100670	8	None	-2	4	Human	7.4	pEC50	=	7.4	Binding	Antagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assayAntagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
	CHEMBL540857	100670	8	None	-2	4	Human	7.4	pEC50	=	7.4	Binding	Antagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assayAntagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
	146025823	169553	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	CHEMBL4435882	169553	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	146025823	169553	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	CHEMBL4435882	169553	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	85090322	179435	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4740678	179435	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	75201899	171892	0	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
	CHEMBL4469983	171892	0	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
	228	444	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	33	444	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6005	444	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL53	444	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	DB00714	444	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	3033200	174503	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	CHEMBL4555547	174503	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	85090333	181277	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4762375	181277	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090326	182749	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4790277	182749	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	228	444	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	33	444	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6005	444	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL53	444	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	DB00714	444	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	3033200	174503	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	CHEMBL4555547	174503	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	85090332	180695	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4755709	180695	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	6852376	91570	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
	CHEMBL1467585	91570	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
	CHEMBL24077	91570	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
	CHEMBL503958	91570	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
	146192960	171495	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL4464150	171495	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	85090339	182281	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
	CHEMBL4784143	182281	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
	136326241	179404	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4740312	179404	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	92044504	171703	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4467080	171703	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	92044504	171703	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4467080	171703	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	3045992	176051	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4591021	176051	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	90134269	174182	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4548284	174182	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	90134269	174182	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4548284	174182	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	3045992	176051	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4591021	176051	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	85090329	182658	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4789255	182658	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090331	181429	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4764398	181429	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	76284419	183224	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4796389	183224	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
	9841398	99491	4	None	-3	4	Human	8.1	pEC50	=	8.1	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
	CHEMBL28338	99491	4	None	-3	4	Human	8.1	pEC50	=	8.1	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
	1218	3589	30	None	-11	8	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assayAgonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
	938	3589	30	None	-11	8	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assayAgonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
	CHEMBL353335	3589	30	None	-11	8	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assayAgonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
	72548703	161543	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	CHEMBL4128926	161543	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	3036864	202731	19	None	-2	28	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
	CHEMBL1256645	202731	19	None	-2	28	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
	CHEMBL1814790	202731	19	None	-2	28	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
	CHEMBL62	202731	19	None	-2	28	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
	3036864	202731	19	None	-2	28	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL1256645	202731	19	None	-2	28	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL1814790	202731	19	None	-2	28	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL62	202731	19	None	-2	28	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	5281878	1647	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
	5281881	1647	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
	948	1647	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
	968	1647	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
	CHEMBL42055	1647	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
	CHEMBL54661	1647	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
	DB00875	1647	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
	5018	3523	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
	943	3523	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
	946	3523	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
	CHEMBL13668	3523	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
	5018	3523	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
	943	3523	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
	946	3523	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
	CHEMBL13668	3523	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
	44358126	26648	0	None	-	0	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	315	1	1	2	4.2	C[C@H]1N(C)CCc2cc(Cl)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm00022a004
	CHEMBL136190	26648	0	None	-	0	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	315	1	1	2	4.2	C[C@H]1N(C)CCc2cc(Cl)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm00022a004
	3036864	202731	19	None	-2	28	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
	CHEMBL62	202731	19	None	-2	28	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
	11795296	26736	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136260	26736	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	3036864	202731	19	None	-2	28	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
	CHEMBL1256645	202731	19	None	-2	28	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
	CHEMBL1814790	202731	19	None	-2	28	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
	CHEMBL62	202731	19	None	-2	28	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
	10809333	27160	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136630	27160	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	10522247	26700	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136235	26700	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
	3036864	202731	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
	CHEMBL1256645	202731	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
	CHEMBL1814790	202731	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
	CHEMBL62	202731	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
	10784787	26690	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	360	2	0	3	5.0	CN1CCN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136226	26690	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	360	2	0	3	5.0	CN1CCN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	11795296	26736	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136260	26736	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	3036864	202731	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
	CHEMBL1256645	202731	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
	CHEMBL1814790	202731	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
	CHEMBL62	202731	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
	10712649	119181	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	CHEMBL343282	119181	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	10810927	119270	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	CHEMBL343922	119270	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	10522247	26700	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136235	26700	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
	11794473	119304	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCC2	10.1021/jm00022a004
	CHEMBL344206	119304	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCC2	10.1021/jm00022a004
	10810927	119270	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	CHEMBL343922	119270	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	3036864	202731	19	None	-2	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL1256645	202731	19	None	-2	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL1814790	202731	19	None	-2	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL62	202731	19	None	-2	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	10787324	26825	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	402	4	1	3	4.4	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCO	10.1021/jm00022a004
	CHEMBL136340	26825	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	402	4	1	3	4.4	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCO	10.1021/jm00022a004
	10574585	27394	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	CHEMBL136822	27394	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	3036864	202731	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
	CHEMBL62	202731	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
	3036864	202731	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
	CHEMBL62	202731	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
	10043978	27217	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	CHEMBL136683	27217	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	10525990	27541	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	5	1	3	4.8	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCCO	10.1021/jm00022a004
	CHEMBL136932	27541	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	5	1	3	4.8	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCCO	10.1021/jm00022a004
	10247592	28873	1	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL137960	28873	1	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	6603950	203301	9	None	-6	9	Rat	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
	CHEMBL64875	203301	9	None	-6	9	Rat	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
	6603950	203301	9	None	-6	9	Rat	8.9	pIC50	=	8.9	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
	CHEMBL64875	203301	9	None	-6	9	Rat	8.9	pIC50	=	8.9	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
	107995	97097	20	None	-	5	Rat	8.9	pIC50	=	8.9	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmcl.2003.08.063
	29982233	97097	20	None	-	5	Rat	8.9	pIC50	=	8.9	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmcl.2003.08.063
	CHEMBL267723	97097	20	None	-	5	Rat	8.9	pIC50	=	8.9	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmcl.2003.08.063
	10809333	27160	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136630	27160	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	3036864	202731	19	None	-2	28	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
	CHEMBL1256645	202731	19	None	-2	28	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
	CHEMBL1814790	202731	19	None	-2	28	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
	CHEMBL62	202731	19	None	-2	28	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
	10712649	119181	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	CHEMBL343282	119181	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	3036864	202731	19	None	-2	28	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
	CHEMBL1256645	202731	19	None	-2	28	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
	CHEMBL1814790	202731	19	None	-2	28	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
	CHEMBL62	202731	19	None	-2	28	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
	10835172	119153	0	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	406	2	0	2	5.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL343078	119153	0	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	406	2	0	2	5.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1(C)C	10.1021/jm00022a004
	10247592	28873	1	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL137960	28873	1	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	10525999	27332	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Br)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136776	27332	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Br)cc32)CC1(C)C	10.1021/jm00022a004
	10574585	27394	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	CHEMBL136822	27394	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	5016	109142	8	None	-	2	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00086a016
	CHEMBL32145	109142	8	None	-	2	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00086a016
	CHEMBL544114	109142	8	None	-	2	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00086a016
	146025812	174867	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4564103	174867	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	10049758	204622	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	457	2	0	7	3.7	CN1CCN(C2=Nc3ccccc3Sc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
	CHEMBL73589	204622	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	457	2	0	7	3.7	CN1CCN(C2=Nc3ccccc3Sc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
	177725	173242	2	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)C[C@H]1c3c(ccc(O)c3O2)CCN1C	10.1021/jm060959i
	CHEMBL452510	173242	2	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)C[C@H]1c3c(ccc(O)c3O2)CCN1C	10.1021/jm060959i
	159034	173243	3	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1ccc2c(c1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL452512	173243	3	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1ccc2c(c1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	15657216	12965	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	303	6	0	1	4.8	C=CCN(CC=C)C1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
	CHEMBL1189682	12965	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	303	6	0	1	4.8	C=CCN(CC=C)C1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
	CHEMBL539274	12965	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	303	6	0	1	4.8	C=CCN(CC=C)C1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
	15657214	13206	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	263	4	1	1	3.9	C=CCNC1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
	CHEMBL1191339	13206	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	263	4	1	1	3.9	C=CCNC1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
	CHEMBL542419	13206	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	263	4	1	1	3.9	C=CCNC1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
	10252000	98519	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL27650	98519	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL50188	98519	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	15065270	112329	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	249	2	1	4	2.5	CCCN1CCC2=C(CCc3sc(N)nc32)C1	10.1021/jm00113a010
	CHEMBL329444	112329	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	249	2	1	4	2.5	CCCN1CCC2=C(CCc3sc(N)nc32)C1	10.1021/jm00113a010
	194775	207296	27	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	223	3	1	4	2.2	CCCN1CCC=C(c2csc(N)n2)C1	10.1021/jm00113a010
	CHEMBL93428	207296	27	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	223	3	1	4	2.2	CCCN1CCC=C(c2csc(N)n2)C1	10.1021/jm00113a010
	10008463	11217	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	457	9	0	4	4.3	CCC[N+](C)(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL1178971	11217	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	457	9	0	4	4.3	CCC[N+](C)(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL51985	11217	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	457	9	0	4	4.3	CCC[N+](C)(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	11743327	98674	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	1	5	3.9	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1	10.1021/jm00038a007
	CHEMBL27763	98674	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	1	5	3.9	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1	10.1021/jm00038a007
	131001	98965	7	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	249	5	1	3	2.8	CCCN(CCC)C1COc2cccc(O)c2C1	10.1021/jm00038a007
	CHEMBL27995	98965	7	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	249	5	1	3	2.8	CCCN(CCC)C1COc2cccc(O)c2C1	10.1021/jm00038a007
	10364722	99057	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL280608	99057	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL51888	99057	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	3082597	99531	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL283606	99531	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	9975915	99708	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	362	9	0	5	2.8	CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL284912	99708	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	362	9	0	5	2.8	CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10338595	162475	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	360	9	0	4	4.0	CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL416747	162475	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	360	9	0	4	4.0	CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10707563	28324	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	275	3	0	3	3.3	CCCN1CCCCC12COc1cccc(OC)c1C2	10.1021/jm950861w
	CHEMBL137478	28324	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	275	3	0	3	3.3	CCCN1CCCCC12COc1cccc(OC)c1C2	10.1021/jm950861w
	3082597	99531	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm950861w
	CHEMBL283606	99531	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm950861w
	14138285	145130	6	None	-	1	Human	6.0	pIC50	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
	CHEMBL3912178	145130	6	None	-	1	Human	6.0	pIC50	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
	71109989	153751	0	None	6	2	Human	7.0	pIC50	=	7.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	CHEMBL3982119	153751	0	None	6	2	Human	7.0	pIC50	=	7.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	9992356	9724	1	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
	CHEMBL113477	9724	1	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
	440585	12659	15	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	596	8	3	8	6.2	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2	10.1021/np50087a016
	CHEMBL1187468	12659	15	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	596	8	3	8	6.2	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2	10.1021/np50087a016
	CHEMBL503882	12659	15	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	596	8	3	8	6.2	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2	10.1021/np50087a016
	135221	145194	5	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
	CHEMBL3912606	145194	5	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
	135398737	955	93	None	-44	92	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	955	93	None	-44	92	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	955	93	None	-44	92	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	955	93	None	-44	92	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	955	93	None	-44	92	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	10015045	13620	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
	CHEMBL119455	13620	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
	6603799	99686	17	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@H](c1ccccc1)CNCC2	10.1021/jm00086a016
	CHEMBL284746	99686	17	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@H](c1ccccc1)CNCC2	10.1021/jm00086a016
	150	2492	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	1764	2492	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	8226	2492	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	CHEMBL1201356	2492	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	DB00353	2492	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	14901831	13352	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	CHEMBL1192581	13352	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	CHEMBL543838	13352	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	3168	9230	92	None	-89	22	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	CHEMBL1108	9230	92	None	-89	22	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	16104	161893	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm991005d
	CHEMBL415300	161893	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm991005d
	16104	161893	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm9704457
	CHEMBL415300	161893	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm9704457
	6603820	95745	19	None	1	13	Rat	7.9	pIC50	=	7.9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
	CHEMBL25856	95745	19	None	1	13	Rat	7.9	pIC50	=	7.9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
	1353	1898	93	None	-38	86	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	3559	1898	93	None	-38	86	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	86	1898	93	None	-38	86	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	CHEMBL54	1898	93	None	-38	86	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	DB00502	1898	93	None	-38	86	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	10015045	13620	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
	CHEMBL119455	13620	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
	146025812	174867	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4564103	174867	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	10043978	27217	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	CHEMBL136683	27217	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	14901827	13021	1	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	225	6	1	2	2.8	CCCN(CC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	CHEMBL1190039	13021	1	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	225	6	1	2	2.8	CCCN(CC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	CHEMBL540036	13021	1	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	225	6	1	2	2.8	CCCN(CC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	44584684	12410	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@H](Cc1ccc(OC)c(c1)-c1cc(ccc1O)C(=O)[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
	CHEMBL1186001	12410	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@H](Cc1ccc(OC)c(c1)-c1cc(ccc1O)C(=O)[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
	CHEMBL445011	12410	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@H](Cc1ccc(OC)c(c1)-c1cc(ccc1O)C(=O)[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
	2398	951	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	2801	951	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	701	951	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	CHEMBL415	951	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	DB01242	951	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	44317479	205722	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.	ChEMBL	243	4	3	3	2.4	NCC(Cc1ccccc1)c1ccc(O)c(O)c1	10.1021/jm00013a015
	CHEMBL82706	205722	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.	ChEMBL	243	4	3	3	2.4	NCC(Cc1ccccc1)c1ccc(O)c(O)c1	10.1021/jm00013a015
	10885636	110989	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL326263	110989	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	10024827	13105	2	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1cccc(O)c1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL1190552	13105	2	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1cccc(O)c1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL541096	13105	2	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1cccc(O)c1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	70684206	76036	0	None	11	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
	CHEMBL2057442	76036	0	None	11	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
	70692652	76035	0	None	8	2	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
	CHEMBL2057441	76035	0	None	8	2	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
	10547041	23782	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.8	Oc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
	CHEMBL133615	23782	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.8	Oc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
	14901829	13111	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	239	7	1	2	3.2	CCCN(CCC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	CHEMBL1190633	13111	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	239	7	1	2	3.2	CCCN(CCC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	CHEMBL541304	13111	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	239	7	1	2	3.2	CCCN(CCC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	10264849	9335	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	265	0	1	2	3.3	CN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
	CHEMBL111348	9335	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	265	0	1	2	3.3	CN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
	107715	200922	22	None	-144	20	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL1255837	200922	22	None	-144	20	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL601773	200922	22	None	-144	20	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	8447	188925	84	None	-8	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
	CHEMBL508112	188925	84	None	-8	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
	3191	102831	97	None	-12	25	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	CHEMBL305660	102831	97	None	-12	25	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	13154762	103083	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
	CHEMBL307717	103083	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
	15648961	107374	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	341	2	0	1	5.4	CN1CCC(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
	CHEMBL317982	107374	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	341	2	0	1	5.4	CN1CCC(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
	6603820	95745	19	None	1	13	Rat	7.9	pIC50	=	7.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00168a034
	CHEMBL25856	95745	19	None	1	13	Rat	7.9	pIC50	=	7.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00168a034
	6917970	3665	61	None	-1	34	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	8370	3665	61	None	-1	34	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	CHEMBL487387	3665	61	None	-1	34	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	6604005	157093	2	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm00168a034
	CHEMBL407489	157093	2	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm00168a034
	10361722	22188	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.5	Oc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
	CHEMBL132304	22188	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.5	Oc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
	10333742	59370	1	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	277	2	0	1	4.1	c1ccc(CN2CCCC3Cc4ccccc4CC32)cc1	10.1016/s0960-894x(01)00076-2
	CHEMBL170974	59370	1	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	277	2	0	1	4.1	c1ccc(CN2CCCC3Cc4ccccc4CC32)cc1	10.1016/s0960-894x(01)00076-2
	42	2050	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
	56971	2050	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
	CHEMBL8412	2050	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
	42	2050	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950861w
	56971	2050	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950861w
	CHEMBL8412	2050	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950861w
	44370646	48185	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@H](C2)N(C)CC3	10.1021/jm00164a022
	CHEMBL155246	48185	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@H](C2)N(C)CC3	10.1021/jm00164a022
	44269133	33905	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	356	2	3	3	2.1	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
	CHEMBL14239	33905	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	356	2	3	3	2.1	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
	72329	95619	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	337	2	2	5	4.0	COc1c(O)c2c3c(nccc3c1OC)C(C)(C)c1cc(O)ccc1-2	10.1021/jm060959i
	CHEMBL257958	95619	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	337	2	2	5	4.0	COc1c(O)c2c3c(nccc3c1OC)C(C)(C)c1cc(O)ccc1-2	10.1021/jm060959i
	64143	198841	62	None	-1	8	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
	CHEMBL584	198841	62	None	-1	8	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
	10523361	29794	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC(C)N1C	10.1021/jm00022a004
	CHEMBL138745	29794	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC(C)N1C	10.1021/jm00022a004
	10567738	119380	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	320	2	0	2	4.3	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL344680	119380	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	320	2	0	2	4.3	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
	71109797	145871	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
	CHEMBL3917753	145871	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
	135398737	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
	38	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
	722	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
	CHEMBL42	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
	DB00363	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
	15653096	207867	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1	10.1021/jm00022a004
	CHEMBL1788129	207867	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1	10.1021/jm00022a004
	CHEMBL96618	207867	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1	10.1021/jm00022a004
	135398737	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
	38	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
	722	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
	CHEMBL42	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
	DB00363	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
	135398737	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
	38	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
	722	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
	CHEMBL42	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
	DB00363	955	93	None	-83	92	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
	100	3776	58	None	-16	56	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
	2637	3776	58	None	-16	56	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
	5452	3776	58	None	-16	56	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
	CHEMBL479	3776	58	None	-16	56	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
	DB00679	3776	58	None	-16	56	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
	131213	5270	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
	CHEMBL106622	5270	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
	131213	5270	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	CHEMBL106622	5270	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	44312870	204554	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
	CHEMBL73082	204554	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
	44285576	142226	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C/c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
	CHEMBL38848	142226	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C/c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
	12545	47629	12	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	281	1	1	3	3.2	COc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
	CHEMBL154709	47629	12	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	281	1	1	3	3.2	COc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
	195158	43121	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
	CHEMBL150550	43121	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
	44267161	163018	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	456	10	0	5	4.4	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
	CHEMBL417608	163018	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	456	10	0	5	4.4	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
	70690498	76038	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057445	76038	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	71109805	87476	0	None	27	3	Human	7.8	pIC50	=	7.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
	CHEMBL2334881	87476	0	None	27	3	Human	7.8	pIC50	=	7.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
	70690500	76044	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
	CHEMBL2057455	76044	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
	70692653	76037	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
	CHEMBL2057443	76037	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
	70692653	76037	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	CHEMBL2057443	76037	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	146025817	175993	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4589737	175993	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	22857296	29119	0	None	-	4	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	CHEMBL13816	29119	0	None	-	4	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	146025817	175993	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4589737	175993	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	15720219	68636	1	None	-	1	Rat	4.8	pIC50	=	4.8	Binding	Compound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranesCompound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranes	ChEMBL	220	5	0	2	2.9	CCCN(CCC)[C@H]1CCn2cccc2C1	10.1016/S0960-894X(00)80003-7
	CHEMBL192037	68636	1	None	-	1	Rat	4.8	pIC50	=	4.8	Binding	Compound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranesCompound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranes	ChEMBL	220	5	0	2	2.9	CCCN(CCC)[C@H]1CCn2cccc2C1	10.1016/S0960-894X(00)80003-7
	146025813	175563	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	175563	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	6603820	95745	19	None	1	13	Rat	6.8	pIC50	=	6.8	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
	CHEMBL25856	95745	19	None	1	13	Rat	6.8	pIC50	=	6.8	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
	2585	800	103	None	-112	22	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	522	800	103	None	-112	22	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	551	800	103	None	-112	22	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	CHEMBL723	800	103	None	-112	22	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	DB01136	800	103	None	-112	22	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	71474024	144443	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
	CHEMBL3906676	144443	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
	10247592	28873	1	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL137960	28873	1	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	146025816	169954	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4442011	169954	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	146025816	169954	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4442011	169954	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	44190762	176856	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from dopamine D1 receptorDisplacement of radioligand from dopamine D1 receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
	CHEMBL461571	176856	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from dopamine D1 receptorDisplacement of radioligand from dopamine D1 receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
	26987	946	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	6063	946	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	671	946	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	CHEMBL1626	946	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	DB00283	946	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	9851833	12408	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	608	3	1	8	6.9	COc1ccc2cc1Oc1ccc(cc1)C[C@@H]1c3c(cc(OC)c(O)c3Oc3cc4c(cc3OC)CCN(C)[C@H]4C2)CCN1C	10.1021/np50087a016
	CHEMBL1185978	12408	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	608	3	1	8	6.9	COc1ccc2cc1Oc1ccc(cc1)C[C@@H]1c3c(cc(OC)c(O)c3Oc3cc4c(cc3OC)CCN(C)[C@H]4C2)CCN1C	10.1021/np50087a016
	CHEMBL443953	12408	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	608	3	1	8	6.9	COc1ccc2cc1Oc1ccc(cc1)C[C@@H]1c3c(cc(OC)c(O)c3Oc3cc4c(cc3OC)CCN(C)[C@H]4C2)CCN1C	10.1021/np50087a016
	2274	3151	58	None	-16	32	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	4917	3151	58	None	-16	32	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	7279	3151	58	None	-16	32	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	CHEMBL728	3151	58	None	-16	32	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	DB00433	3151	58	None	-16	32	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	44284723	138096	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C/C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
	CHEMBL37661	138096	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C/C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
	277	1289	62	None	-47	46	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2913	1289	62	None	-47	46	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	765	1289	62	None	-47	46	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	CHEMBL516	1289	62	None	-47	46	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	DB00434	1289	62	None	-47	46	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	146025815	169755	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4439029	169755	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	15115476	27075	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	2	0	2	4.2	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
	CHEMBL136553	27075	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	2	0	2	4.2	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
	10320519	27084	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	4	1	3	3.2	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
	CHEMBL136562	27084	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	4	1	3	3.2	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
	146025815	169755	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4439029	169755	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	10732779	188247	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	297	4	2	3	3.7	CCCN1CCc2cc(O)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm001128u
	CHEMBL49995	188247	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	297	4	2	3	3.7	CCCN1CCc2cc(O)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm001128u
	10264176	111299	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
	CHEMBL326781	111299	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
	10048240	13362	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	347	9	2	3	4.6	CCCN(CCCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL1192639	13362	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	347	9	2	3	4.6	CCCN(CCCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL543914	13362	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	347	9	2	3	4.6	CCCN(CCCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	44358170	28256	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	378	2	0	2	4.7	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
	CHEMBL137430	28256	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	378	2	0	2	4.7	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
	100	3776	58	None	-16	56	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
	2637	3776	58	None	-16	56	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
	5452	3776	58	None	-16	56	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
	CHEMBL479	3776	58	None	-16	56	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
	DB00679	3776	58	None	-16	56	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
	44370644	48771	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm060959i
	CHEMBL155884	48771	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm060959i
	240	941	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
	2769	941	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
	44279790	941	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
	660	941	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
	CHEMBL1729	941	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
	CHEMBL560739	941	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
	DB00604	941	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
	44370644	48771	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
	CHEMBL155884	48771	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
	6603798	100152	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
	CHEMBL1613539	100152	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
	CHEMBL288096	100152	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
	6603798	100152	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	CHEMBL1613539	100152	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	CHEMBL288096	100152	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	14140118	95567	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	1	4	3.2	COc1c(O)c2c3c(c1OC)CCN(C)C3Cc1ccccc1-2	10.1021/jm060959i
	CHEMBL257747	95567	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	1	4	3.2	COc1c(O)c2c3c(c1OC)CCN(C)C3Cc1ccccc1-2	10.1021/jm060959i
	1043	1569	14	None	-9549	29	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	149	1569	14	None	-9549	29	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	8223	1569	14	None	-9549	29	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL442	1569	14	None	-9549	29	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00696	1569	14	None	-9549	29	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	1588	2311	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	28864	2311	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	43	2311	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	CHEMBL157138	2311	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	DB00589	2311	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	15653097	207169	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
	CHEMBL2111567	207169	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
	CHEMBL92560	207169	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
	9979207	13806	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL1195842	13806	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL555427	13806	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	44370749	48709	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
	CHEMBL155833	48709	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
	70692652	76035	0	None	8	2	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057441	76035	0	None	8	2	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	6603729	99928	2	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@H](c2ccccc2)C1	10.1021/jm00086a016
	CHEMBL286424	99928	2	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@H](c2ccccc2)C1	10.1021/jm00086a016
	192611	13537	7	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	301	2	1	2	4.1	CN(C)[C@H]1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
	CHEMBL1193985	13537	7	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	301	2	1	2	4.1	CN(C)[C@H]1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
	CHEMBL545477	13537	7	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	301	2	1	2	4.1	CN(C)[C@H]1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
	10595484	119064	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)C(C)CN1C	10.1021/jm00022a004
	CHEMBL342698	119064	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)C(C)CN1C	10.1021/jm00022a004
	71240	207694	14	None	-	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	408	4	1	3	4.0	OCCN1CCN([C@@H]2C[C@@H](c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00072a006
	CHEMBL95636	207694	14	None	-	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	408	4	1	3	4.0	OCCN1CCN([C@@H]2C[C@@H](c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00072a006
	1241	100151	24	None	-1	8	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00086a016
	CHEMBL288090	100151	24	None	-1	8	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00086a016
	CHEMBL552611	100151	24	None	-1	8	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00086a016
	1242	3586	27	None	1	18	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00086a016
	935	3586	27	None	1	18	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00086a016
	CHEMBL286080	3586	27	None	1	18	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00086a016
	44269117	97284	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	352	2	2	4	3.2	CN1C[C@H](C(=O)Nc2nccs2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	CHEMBL269160	97284	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	352	2	2	4	3.2	CN1C[C@H](C(=O)Nc2nccs2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	10831881	116446	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	4.1	I/C=C/CN1CCC[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm980284m
	CHEMBL336128	116446	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	4.1	I/C=C/CN1CCC[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm980284m
	71474025	145302	0	None	131	2	Human	5.7	pIC50	=	5.7	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	CHEMBL3913343	145302	0	None	131	2	Human	5.7	pIC50	=	5.7	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	135398737	955	93	None	-83	92	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
	38	955	93	None	-83	92	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
	722	955	93	None	-83	92	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
	CHEMBL42	955	93	None	-83	92	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
	DB00363	955	93	None	-83	92	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
	135398737	955	93	None	-83	92	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
	38	955	93	None	-83	92	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
	722	955	93	None	-83	92	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
	CHEMBL42	955	93	None	-83	92	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
	DB00363	955	93	None	-83	92	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
	100	3776	58	None	-47	56	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2637	3776	58	None	-47	56	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	5452	3776	58	None	-47	56	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	CHEMBL479	3776	58	None	-47	56	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	DB00679	3776	58	None	-47	56	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	129503	161644	10	None	-	5	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
	CHEMBL413105	161644	10	None	-	5	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
	2750	204038	76	None	-5	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	CHEMBL7002	204038	76	None	-5	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	10043978	27217	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	CHEMBL136683	27217	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	10641744	31298	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	352	2	0	2	4.7	Cc1ccc2c(c1)C(N1CCN(C)C(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	CHEMBL140189	31298	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	352	2	0	2	4.7	Cc1ccc2c(c1)C(N1CCN(C)C(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	10810109	115469	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	Fc1ccc(C2CC(N3CCN4CCCCC4C3)c3cc(Cl)ccc32)cc1	10.1021/jm00022a004
	CHEMBL335155	115469	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	Fc1ccc(C2CC(N3CCN4CCCCC4C3)c3cc(Cl)ccc32)cc1	10.1021/jm00022a004
	9819535	98919	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.	ChEMBL	344	2	1	4	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(N=C=S)c2)C1	10.1016/0960-894X(96)00186-2
	CHEMBL279634	98919	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.	ChEMBL	344	2	1	4	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(N=C=S)c2)C1	10.1016/0960-894X(96)00186-2
	2726	916	68	None	-18	73	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
	621	916	68	None	-18	73	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
	83	916	68	None	-18	73	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
	CHEMBL71	916	68	None	-18	73	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
	DB00477	916	68	None	-18	73	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
	12765746	102253	4	None	-18	10	Rat	8.7	pIC50	=	8.7	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
	CHEMBL303313	102253	4	None	-18	10	Rat	8.7	pIC50	=	8.7	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
	12765746	102253	4	None	-18	10	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
	CHEMBL303313	102253	4	None	-18	10	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
	1238	203151	24	None	-5	17	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
	CHEMBL64249	203151	24	None	-5	17	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
	12765746	102253	4	None	-18	10	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00072a006
	CHEMBL303313	102253	4	None	-18	10	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00072a006
	10666149	119306	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	0	2	4.7	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
	CHEMBL344216	119306	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	0	2	4.7	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
	10246528	27261	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136722	27261	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
	3036864	202731	19	None	-2	28	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL1256645	202731	19	None	-2	28	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL1814790	202731	19	None	-2	28	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL62	202731	19	None	-2	28	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	5018	3523	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	943	3523	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	946	3523	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	CHEMBL13668	3523	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	10810514	27185	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	392	2	1	2	5.1	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CCN1	10.1021/jm00022a004
	CHEMBL136648	27185	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	392	2	1	2	5.1	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CCN1	10.1021/jm00022a004
	135514603	204091	14	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	474	2	1	7	4.0	CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
	CHEMBL70319	204091	14	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	474	2	1	7	4.0	CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
	681	1453	72	None	-23	39	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
	940	1453	72	None	-23	39	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
	947	1453	72	None	-23	39	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
	CHEMBL59	1453	72	None	-23	39	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
	DB00988	1453	72	None	-23	39	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
	15653098	207225	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1	10.1021/jm00022a004
	CHEMBL92896	207225	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1	10.1021/jm00022a004
	121852	10134	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL11592	10134	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL301060	10134	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	9978353	11221	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
	CHEMBL1178987	11221	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
	CHEMBL52785	11221	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
	9981024	96068	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL26018	96068	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL300735	96068	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10319624	98959	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL27991	98959	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL298534	98959	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	9980269	99055	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL280586	99055	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL54266	99055	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10321248	99398	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL28287	99398	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL50722	99398	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	121852	10134	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
	CHEMBL11592	10134	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
	CHEMBL301060	10134	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
	10333685	88515	3	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	276	1	1	1	3.8	CN1CCc2c([nH]c3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
	CHEMBL23529	88515	3	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	276	1	1	1	3.8	CN1CCc2c([nH]c3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
	14233815	206983	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CCC21	10.1021/jm00113a010
	CHEMBL91453	206983	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CCC21	10.1021/jm00113a010
	71109993	143222	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
	CHEMBL3896617	143222	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
	14547414	102257	1	None	-	5	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
	CHEMBL303339	102257	1	None	-	5	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
	28417	40009	49	None	-1	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
	CHEMBL1479	40009	49	None	-1	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
	10480509	142306	0	None	-	2	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	483	2	2	5	4.4	COc1cc2c(c(Br)c1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
	CHEMBL388564	142306	0	None	-	2	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	483	2	2	5	4.4	COc1cc2c(c(Br)c1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
	44312605	204412	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
	CHEMBL72162	204412	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
	44323851	206951	0	None	3	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
	CHEMBL91310	206951	0	None	3	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
	13154801	27420	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	370	5	1	4	3.0	COc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	CHEMBL136841	27420	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	370	5	1	4	3.0	COc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	24121307	103016	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(C)(=O)=O)cc32)CC1	10.1021/jm991005d
	CHEMBL307163	103016	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(C)(=O)=O)cc32)CC1	10.1021/jm991005d
	3117	207818	103	None	-2	16	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	CHEMBL964	207818	103	None	-2	16	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	147080	205953	5	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.	ChEMBL	365	6	0	6	2.8	O=c1ccoc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc12	10.1021/jm00105a039
	CHEMBL84639	205953	5	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.	ChEMBL	365	6	0	6	2.8	O=c1ccoc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc12	10.1021/jm00105a039
	44354812	25097	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	3.8	I/C=C/CN1CCCC2Cc3ccccc3CC21	10.1021/jm980284m
	CHEMBL134746	25097	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	3.8	I/C=C/CN1CCCC2Cc3ccccc3CC21	10.1021/jm980284m
	44285034	149743	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C\C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
	CHEMBL39483	149743	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C\C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
	135493554	204137	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3cc(OS(C)(=O)=O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
	CHEMBL70609	204137	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3cc(OS(C)(=O)=O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
	125720	26283	5	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	338	2	2	3	1.7	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	CHEMBL13588	26283	5	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	338	2	2	3	1.7	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	9911120	9591	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
	CHEMBL11265	9591	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
	2726	916	68	None	-36	73	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	916	68	None	-36	73	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	916	68	None	-36	73	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	916	68	None	-36	73	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	916	68	None	-36	73	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	4913274	17968	2	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	408	4	1	3	4.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
	CHEMBL12628	17968	2	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	408	4	1	3	4.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
	15648962	108325	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	339	2	0	1	5.3	CN1CC=C(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
	CHEMBL319810	108325	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	339	2	0	1	5.3	CN1CC=C(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
	1212	1649	50	None	-51	66	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1649	50	None	-51	66	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1649	50	None	-51	66	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1649	50	None	-51	66	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1649	50	None	-51	66	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	146025814	172755	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	172755	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	9911120	9591	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
	CHEMBL11265	9591	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
	11744707	164885	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	454	6	0	5	4.3	COc1cccc2c1CC1(CCCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
	CHEMBL422283	164885	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	454	6	0	5	4.3	COc1cccc2c1CC1(CCCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
	228	444	28	None	-30	24	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
	33	444	28	None	-30	24	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
	6005	444	28	None	-30	24	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
	CHEMBL53	444	28	None	-30	24	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
	DB00714	444	28	None	-30	24	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
	10400783	194862	0	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	267	2	1	3	2.8	c1ccc(C[C@@H]2NCCc3cc4c(cc32)OCO4)cc1	10.1021/jm001128u
	CHEMBL54051	194862	0	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	267	2	1	3	2.8	c1ccc(C[C@@H]2NCCc3cc4c(cc32)OCO4)cc1	10.1021/jm001128u
	10531	1408	21	None	-218	24	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	121	1408	21	None	-218	24	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	888	1408	21	None	-218	24	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL1732	1408	21	None	-218	24	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00320	1408	21	None	-218	24	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	440989	95271	27	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	285	3	3	4	2.5	COc1cc2c(cc1O)[C@@H](Cc1ccc(O)cc1)NCC2	10.1021/np980008a
	CHEMBL256448	95271	27	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	285	3	3	4	2.5	COc1cc2c(cc1O)[C@@H](Cc1ccc(O)cc1)NCC2	10.1021/np980008a
	10408602	13664	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	317	8	1	2	4.5	CCCN(CCc1ccccc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL1194852	13664	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	317	8	1	2	4.5	CCCN(CCc1ccccc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL553399	13664	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	317	8	1	2	4.5	CCCN(CCc1ccccc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	2284	3160	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	4926	3160	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	7281	3160	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	CHEMBL564	3160	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	DB00420	3160	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	10246528	27261	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136722	27261	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
	22179	186241	42	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	3	5	2.5	COc1cc2c(cc1O)C[C@@H]1NCCc3cc(O)c(OC)c-2c31	10.1021/jm060959i
	CHEMBL487388	186241	42	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	3	5	2.5	COc1cc2c(cc1O)C[C@@H]1NCCc3cc(O)c(OC)c-2c31	10.1021/jm060959i
	11035765	9856	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	359	6	2	6	3.3	Oc1nc2ccccc2n1CCCNCc1cc2c(cc1Cl)OCO2	10.1021/jm010878g
	CHEMBL114280	9856	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	359	6	2	6	3.3	Oc1nc2ccccc2n1CCCNCc1cc2c(cc1Cl)OCO2	10.1021/jm010878g
	49836496	18523	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	246	2	1	1	3.5	CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1	10.1021/jm100515z
	CHEMBL1275791	18523	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	246	2	1	1	3.5	CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1	10.1021/jm100515z
	146025814	172755	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	172755	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	197505	13659	16	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	171	2	2	2	1.5	NCCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL1194829	13659	16	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	171	2	2	2	1.5	NCCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL553361	13659	16	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	171	2	2	2	1.5	NCCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	441383	20301	57	None	-12	17	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	CHEMBL1306	20301	57	None	-12	17	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	2600	3750	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	2608	3750	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	5405	3750	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	CHEMBL17157	3750	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	DB00342	3750	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	10762505	164833	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	4.1	COc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
	CHEMBL421914	164833	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	4.1	COc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
	2477	742	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
	36	742	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
	437	742	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
	CHEMBL49	742	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
	DB00490	742	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
	44342270	9898	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
	CHEMBL114484	9898	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
	2286	3161	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	4927	3161	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	7282	3161	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	CHEMBL643	3161	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	DB01069	3161	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	11730467	10996	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	CHEMBL117537	10996	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	11080	29054	79	None	-5	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	CHEMBL1381098	29054	79	None	-5	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	5352624	67209	44	None	-3	5	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
	CHEMBL18797	67209	44	None	-3	5	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
	2662	11352	131	None	-3	31	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
	CHEMBL118	11352	131	None	-3	31	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
	13154762	103083	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
	CHEMBL307717	103083	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
	6603997	99882	12	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00086a016
	CHEMBL286120	99882	12	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00086a016
	15723883	206096	1	None	-	1	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	294	6	0	2	3.8	c1ccc(CCCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm00116a003
	CHEMBL85879	206096	1	None	-	1	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	294	6	0	2	3.8	c1ccc(CCCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm00116a003
	31101	726	40	None	-436	36	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	35	726	40	None	-436	36	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	403	726	40	None	-436	36	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	CHEMBL493	726	40	None	-436	36	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	DB01200	726	40	None	-436	36	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	10264175	108574	1	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@@H]21	10.1021/jm00002a013
	CHEMBL320481	108574	1	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@@H]21	10.1021/jm00002a013
	196129	67769	17	None	-1819	15	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	CHEMBL1909065	67769	17	None	-1819	15	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	70684207	76041	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	CHEMBL2057452	76041	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	70684207	76041	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
	CHEMBL2057452	76041	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
	14547415	100643	1	None	-	4	Rat	4.5	pIC50	=	4.5	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
	CHEMBL292274	100643	1	None	-	4	Rat	4.5	pIC50	=	4.5	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
	73453	29585	24	None	-208	17	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	CHEMBL1385840	29585	24	None	-208	17	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	195158	43121	1	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
	CHEMBL150550	43121	1	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
	21589014	144047	0	None	1	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	CHEMBL3903297	144047	0	None	1	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	10246528	27261	0	None	-	0	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136722	27261	0	None	-	0	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
	10004036	95200	0	None	33	2	Rat	8.5	pIC50	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
	CHEMBL256075	95200	0	None	33	2	Rat	8.5	pIC50	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
	10570260	28410	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(F)c32)CC1(C)C	10.1021/jm00022a004
	CHEMBL137536	28410	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(F)c32)CC1(C)C	10.1021/jm00022a004
	70692655	76045	0	None	8	2	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
	CHEMBL2057456	76045	0	None	8	2	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
	15723897	9462	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	330	5	0	2	4.6	c1ccc(N2CCN(CCCc3ccc4ccccc4c3)CC2)cc1	10.1021/jm00116a003
	CHEMBL112037	9462	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	330	5	0	2	4.6	c1ccc(N2CCN(CCCc3ccc4ccccc4c3)CC2)cc1	10.1021/jm00116a003
	228	444	28	None	-30	24	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
	33	444	28	None	-30	24	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
	6005	444	28	None	-30	24	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
	CHEMBL53	444	28	None	-30	24	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
	DB00714	444	28	None	-30	24	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
	681	1453	72	None	-97	39	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
	940	1453	72	None	-97	39	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
	947	1453	72	None	-97	39	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
	CHEMBL59	1453	72	None	-97	39	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
	DB00988	1453	72	None	-97	39	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
	9861399	33267	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	307	2	0	2	4.9	CCN1CCc2c(sc3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
	CHEMBL141863	33267	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	307	2	0	2	4.9	CCN1CCc2c(sc3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
	10251234	11213	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL1178932	11213	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL50530	11213	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10429859	12010	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
	CHEMBL1183429	12010	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
	CHEMBL296395	12010	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
	10476735	13699	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL1195096	13699	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL553833	13699	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	9981024	96068	0	None	-	1	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL26018	96068	0	None	-	1	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL300735	96068	0	None	-	1	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	44312603	103746	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	350	1	0	2	4.9	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
	CHEMBL308843	103746	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	350	1	0	2	4.9	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
	14728694	5317	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	2	0	3	4.1	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/jm00174a002
	CHEMBL106886	5317	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	2	0	3	4.1	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/jm00174a002
	44319215	13172	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	265	2	0	1	4.1	CN(C)[C@@]1(C)Cc2ccccc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
	CHEMBL1191117	13172	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	265	2	0	1	4.1	CN(C)[C@@]1(C)Cc2ccccc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
	CHEMBL542167	13172	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	265	2	0	1	4.1	CN(C)[C@@]1(C)Cc2ccccc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
	11057	176125	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	3468	176125	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL459265	176125	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL64894	176125	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	10809334	26816	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136334	26816	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1(C)C	10.1021/jm00022a004
	6761	67770	19	None	-5	18	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	CHEMBL1909072	67770	19	None	-5	18	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	44285043	154786	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C\c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
	CHEMBL40031	154786	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C\c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
	10043093	203836	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(Br)cc3CC[C@H]21	10.1021/jm00002a013
	CHEMBL68680	203836	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(Br)cc3CC[C@H]21	10.1021/jm00002a013
	70690497	76034	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
	CHEMBL2057438	76034	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
	70690497	76034	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	CHEMBL2057438	76034	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	13994412	11132	1	None	-117	3	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
	CHEMBL117841	11132	1	None	-117	3	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
	7055406	189319	3	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	299	4	2	4	2.8	COc1ccc(C[C@H]2NCCc3cc(O)c(OC)cc32)cc1	10.1021/np980008a
	CHEMBL512542	189319	3	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	299	4	2	4	2.8	COc1ccc(C[C@H]2NCCc3cc(O)c(OC)cc32)cc1	10.1021/np980008a
	9816455	16759	8	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@H]2CNC3	10.1021/jm0101545
	CHEMBL124561	16759	8	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@H]2CNC3	10.1021/jm0101545
	130907	194660	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	CHEMBL53294	194660	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	10091430	9849	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	384	7	1	4	3.3	O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2C1	10.1016/0960-894X(96)00174-6
	CHEMBL11425	9849	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	384	7	1	4	3.3	O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2C1	10.1016/0960-894X(96)00174-6
	457825	172630	40	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3cc(c(OC)cc3CCN1C)Oc1c(OC)c(OC)cc3c1[C@@H](C2)N(C)CC3	10.1021/np50087a016
	CHEMBL449690	172630	40	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3cc(c(OC)cc3CCN1C)Oc1c(OC)c(OC)cc3c1[C@@H](C2)N(C)CC3	10.1021/np50087a016
	CHEMBL506025	172630	40	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3cc(c(OC)cc3CCN1C)Oc1c(OC)c(OC)cc3c1[C@@H](C2)N(C)CC3	10.1021/np50087a016
	130907	194660	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
	CHEMBL53294	194660	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
	44370718	119514	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
	CHEMBL345822	119514	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
	1353	1898	93	None	-74	86	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
	3559	1898	93	None	-74	86	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
	86	1898	93	None	-74	86	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
	CHEMBL54	1898	93	None	-74	86	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
	DB00502	1898	93	None	-74	86	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
	10548369	30414	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	388	2	0	2	5.6	CN1CCN(C2CC(c3ccc(Cl)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL139258	30414	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	388	2	0	2	5.6	CN1CCN(C2CC(c3ccc(Cl)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	9979258	98088	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	415	3	2	2	4.9	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	CHEMBL273526	98088	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	415	3	2	2	4.9	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	44267181	9579	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.	ChEMBL	277	7	0	3	3.4	CCCN(CCC)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
	CHEMBL11262	9579	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.	ChEMBL	277	7	0	3	3.4	CCCN(CCC)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
	6852376	91570	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
	CHEMBL1467585	91570	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
	CHEMBL24077	91570	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
	CHEMBL503958	91570	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
	44269085	24957	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	CHEMBL13464	24957	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	180	400	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	200	400	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	2160	400	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	CHEMBL629	400	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	DB00321	400	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	1353	1898	93	None	-74	86	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
	3559	1898	93	None	-74	86	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
	86	1898	93	None	-74	86	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
	CHEMBL54	1898	93	None	-74	86	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
	DB00502	1898	93	None	-74	86	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
	1353	1898	93	None	-74	86	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
	3559	1898	93	None	-74	86	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
	86	1898	93	None	-74	86	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
	CHEMBL54	1898	93	None	-74	86	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
	DB00502	1898	93	None	-74	86	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
	164710	95566	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	4	2.5	Oc1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
	CHEMBL257746	95566	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	4	2.5	Oc1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
	736083	162190	17	None	-50	2	Rat	5.4	pIC50	=	5.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00164a022
	CHEMBL416288	162190	17	None	-50	2	Rat	5.4	pIC50	=	5.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00164a022
	10619325	27478	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136891	27478	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1(C)C	10.1021/jm00022a004
	71110290	147135	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	CHEMBL3927835	147135	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	681	1453	72	None	-97	39	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
	940	1453	72	None	-97	39	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
	947	1453	72	None	-97	39	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
	CHEMBL59	1453	72	None	-97	39	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
	DB00988	1453	72	None	-97	39	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
	4011	82379	49	None	-64	24	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	CHEMBL21731	82379	49	None	-64	24	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	11005810	10434	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL116463	10434	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	44358128	26982	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	324	2	0	2	4.0	Cc1ccc2c(c1)C(N1CCN(C)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	CHEMBL136480	26982	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	324	2	0	2	4.0	Cc1ccc2c(c1)C(N1CCN(C)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	14901835	12883	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(O)c(F)c1	10.1021/jm00171a014
	CHEMBL1189074	12883	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(O)c(F)c1	10.1021/jm00171a014
	CHEMBL538012	12883	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(O)c(F)c1	10.1021/jm00171a014
	10527884	28343	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	458	8	1	5	3.9	COc1cccc2c1CC1(CCCCN1CCCCNS(=O)(=O)c1ccc(C)cc1)CO2	10.1021/jm950861w
	CHEMBL137486	28343	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	458	8	1	5	3.9	COc1cccc2c1CC1(CCCCN1CCCCNS(=O)(=O)c1ccc(C)cc1)CO2	10.1021/jm950861w
	44269075	28588	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	CHEMBL13770	28588	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	10550367	115181	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	426	7	1	4	4.2	COc1cccc2c1CC1(CCCCN1CCCCNC(=O)c1ccc(F)cc1)CO2	10.1021/jm950861w
	CHEMBL334498	115181	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	426	7	1	4	4.2	COc1cccc2c1CC1(CCCCN1CCCCNC(=O)c1ccc(F)cc1)CO2	10.1021/jm950861w
	228	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
	33	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
	6005	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
	CHEMBL53	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
	DB00714	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
	228	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
	33	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
	6005	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
	CHEMBL53	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
	DB00714	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
	228	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
	33	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
	6005	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
	CHEMBL53	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
	DB00714	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
	2351	3261	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	2820	3261	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	5035	3261	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	CHEMBL81	3261	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	DB00481	3261	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	12488	1644	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	941361	1644	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	CHEMBL30008	1644	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	DB04841	1644	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	13154803	116723	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	386	5	1	4	3.7	CSc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	CHEMBL337542	116723	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	386	5	1	4	3.7	CSc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	100231	177894	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3c(cc(OC)c(OC)c3Oc3cc4c(cc3OC)CCN(C)[C@@H]4C2)CCN1C	10.1021/np50087a016
	CHEMBL451211	177894	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3c(cc(OC)c(OC)c3Oc3cc4c(cc3OC)CCN(C)[C@@H]4C2)CCN1C	10.1021/np50087a016
	CHEMBL464525	177894	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3c(cc(OC)c(OC)c3Oc3cc4c(cc3OC)CCN(C)[C@@H]4C2)CCN1C	10.1021/np50087a016
	191	402	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	201	402	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2170	402	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	CHEMBL1113	402	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	DB00543	402	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	121852	10134	7	None	-	1	Human	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
	CHEMBL11592	10134	7	None	-	1	Human	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
	CHEMBL301060	10134	7	None	-	1	Human	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
	10452020	118249	3	None	-	3	Rat	8.4	pIC50	=	8.4	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm00086a016
	CHEMBL34095	118249	3	None	-	3	Rat	8.4	pIC50	=	8.4	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm00086a016
	3036864	202731	19	None	-2	28	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
	CHEMBL1256645	202731	19	None	-2	28	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
	CHEMBL1814790	202731	19	None	-2	28	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
	CHEMBL62	202731	19	None	-2	28	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
	3036864	202731	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1256645	202731	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1814790	202731	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL62	202731	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	3036864	202731	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1256645	202731	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1814790	202731	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL62	202731	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	10809335	26968	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccccc3F)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136468	26968	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccccc3F)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	70690500	76044	0	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057455	76044	0	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	3496768	95711	4	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	0	1	4	2.9	CN1CCc2cc3c(c4c2C1Cc1cccc(O)c1-4)OCO3	10.1021/jm060959i
	CHEMBL258370	95711	4	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	0	1	4	2.9	CN1CCc2cc3c(c4c2C1Cc1cccc(O)c1-4)OCO3	10.1021/jm060959i
	10154	142104	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
	CHEMBL388342	142104	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
	10154	142104	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/np990433j
	CHEMBL388342	142104	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/np990433j
	9981671	14509	0	None	-	1	Rat	6.4	pIC50	=	6.4	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	459	7	1	9	3.1	COc1ccccc1N1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
	CHEMBL12028	14509	0	None	-	1	Rat	6.4	pIC50	=	6.4	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	459	7	1	9	3.1	COc1ccccc1N1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
	121852	10134	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL11592	10134	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL301060	10134	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10251234	11213	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL1178932	11213	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL50530	11213	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10047322	97111	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
	CHEMBL26783	97111	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
	CHEMBL50993	97111	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
	10251673	99462	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL283207	99462	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL52396	99462	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10070029	165393	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL423841	165393	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL54089	165393	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10265863	193300	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	283	5	0	2	4.3	CCCN(CCC)C1COc2ccc3ccccc3c2C1	10.1021/jm00038a007
	CHEMBL52438	193300	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	283	5	0	2	4.3	CCCN(CCC)C1COc2ccc3ccccc3c2C1	10.1021/jm00038a007
	121852	10134	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
	CHEMBL11592	10134	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
	CHEMBL301060	10134	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
	2247	504	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	504	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	504	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	504	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	504	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	134551	357	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	271	357	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	885	357	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	CHEMBL1403281	357	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	146025811	171737	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	171737	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025811	171737	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	171737	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	5353853	17954	47	None	-19	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	9556529	17954	47	None	-19	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1262	17954	47	None	-19	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	10498684	31609	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	359	3	2	2	3.6	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	CHEMBL14048	31609	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	359	3	2	2	3.6	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	71474079	143239	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	CHEMBL3896731	143239	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	2337	3232	77	None	-53	63	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	50	3232	77	None	-53	63	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	5002	3232	77	None	-53	63	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	CHEMBL716	3232	77	None	-53	63	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	DB01224	3232	77	None	-53	63	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	11016	203584	38	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	173	3	0	1	0.0	O=P(N1CC1)(N1CC1)N1CC1	10.1021/jm980284m
	CHEMBL670	203584	38	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	173	3	0	1	0.0	O=P(N1CC1)(N1CC1)N1CC1	10.1021/jm980284m
	228	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
	33	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
	6005	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
	CHEMBL53	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
	DB00714	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
	228	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
	33	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
	6005	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
	CHEMBL53	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
	DB00714	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
	332915	29687	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	240	0	1	1	3.1	C[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
	CHEMBL13866	29687	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	240	0	1	1	3.1	C[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
	10712649	119181	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	CHEMBL343282	119181	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
	5353432	97467	89	None	-1	3	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
	CHEMBL270299	97467	89	None	-1	3	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
	44323870	111564	0	None	3	4	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
	CHEMBL328246	111564	0	None	3	4	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
	228	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
	33	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
	6005	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
	CHEMBL53	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
	DB00714	444	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
	9864292	30077	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL138964	30077	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1(C)C	10.1021/jm00022a004
	70682088	76039	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057446	76039	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	14004813	59254	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	307	3	0	2	4.1	COc1cccc2c1CC1CCCN(Cc3ccccc3)C1C2	10.1016/s0960-894x(01)00076-2
	CHEMBL170475	59254	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	307	3	0	2	4.1	COc1cccc2c1CC1CCCN(Cc3ccccc3)C1C2	10.1016/s0960-894x(01)00076-2
	CHEMBL1200633	208577	3	None	-7	8	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
	44269057	31313	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	412	2	3	3	3.4	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
	CHEMBL14020	31313	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	412	2	3	3	3.4	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
	71110293	143354	0	None	6	3	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	CHEMBL3897805	143354	0	None	6	3	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	2389	3306	118	None	-489	68	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	5073	3306	118	None	-489	68	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	96	3306	118	None	-489	68	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	CHEMBL85	3306	118	None	-489	68	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	DB00734	3306	118	None	-489	68	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	44358098	119258	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	292	2	0	2	3.5	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
	CHEMBL343820	119258	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	292	2	0	2	3.5	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
	133381	95565	9	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	4	2.8	COc1c2c3c(c4c1OCO4)-c1ccccc1C[C@H]3NCC2	10.1021/jm060959i
	CHEMBL257745	95565	9	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	4	2.8	COc1c2c3c(c4c1OCO4)-c1ccccc1C[C@H]3NCC2	10.1021/jm060959i
	71110293	143354	0	None	6	3	Human	6.3	pIC50	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	CHEMBL3897805	143354	0	None	6	3	Human	6.3	pIC50	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	71474026	154275	0	None	1	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
	CHEMBL3986624	154275	0	None	1	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
	45482789	198902	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
	CHEMBL584554	198902	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
	5024	119224	25	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	297	3	0	3	3.3	COc1cc2c(cc1OC)C(c1ccccc1)CN(C)CC2	10.1021/jm980156y
	CHEMBL343569	119224	25	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	297	3	0	3	3.3	COc1cc2c(cc1OC)C(c1ccccc1)CN(C)CC2	10.1021/jm980156y
	10742	3590	31	None	2	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00086a016
	1225	3590	31	None	2	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00086a016
	CHEMBL35354	3590	31	None	2	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00086a016
	13154762	103083	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
	CHEMBL307717	103083	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
	6603820	95745	19	None	1	13	Rat	8.3	pIC50	=	8.3	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
	CHEMBL25856	95745	19	None	1	13	Rat	8.3	pIC50	=	8.3	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
	10617001	31125	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	1	2	4.4	Cc1ccc2c(c1)C(N1CCNC(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	CHEMBL140032	31125	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	1	2	4.4	Cc1ccc2c(c1)C(N1CCNC(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	6852376	91570	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
	CHEMBL1467585	91570	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
	CHEMBL24077	91570	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
	CHEMBL503958	91570	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
	11794523	30207	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	385	2	0	2	5.7	CCN1CCc2c(sc3ccccc23)C(c2cccc(Br)c2)C1	10.1021/jm980156y
	CHEMBL139081	30207	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	385	2	0	2	5.7	CCN1CCc2c(sc3ccccc23)C(c2cccc(Br)c2)C1	10.1021/jm980156y
	10712993	118722	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	352	3	0	4	4.8	CCN1CCc2c(sc3ccccc23)C(c2cccc([N+](=O)[O-])c2)C1	10.1021/jm980156y
	CHEMBL341805	118722	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	352	3	0	4	4.8	CCN1CCc2c(sc3ccccc23)C(c2cccc([N+](=O)[O-])c2)C1	10.1021/jm980156y
	10251234	11213	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL1178932	11213	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL50530	11213	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10364722	99057	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL280608	99057	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL51888	99057	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10072866	197452	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL51561	197452	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL56990	197452	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	11099480	189121	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1ccc2c(c1O)Oc1c(OC)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL510777	189121	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1ccc2c(c1O)Oc1c(OC)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	44370629	51029	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
	CHEMBL157879	51029	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
	10246432	13769	2	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	255	7	1	2	3.7	CCCN(CCC)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL1195595	13769	2	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	255	7	1	2	3.7	CCCN(CCC)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	CHEMBL554950	13769	2	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	255	7	1	2	3.7	CCCN(CCC)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
	44379650	120731	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
	CHEMBL355107	120731	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
	10574585	27394	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	CHEMBL136822	27394	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	13154795	28869	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	4	1	3	3.3	Cc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	CHEMBL137954	28869	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	4	1	3	3.3	Cc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	10582557	194707	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	309	4	0	3	4.0	CCCN1CCc2cc3c(cc2[C@@H]1Cc1ccccc1)OCO3	10.1021/jm001128u
	CHEMBL53520	194707	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	309	4	0	3	4.0	CCCN1CCc2cc3c(cc2[C@@H]1Cc1ccccc1)OCO3	10.1021/jm001128u
	11795296	26736	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136260	26736	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	10424479	108841	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	293	2	1	2	4.1	CCCN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
	CHEMBL321040	108841	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	293	2	1	2	4.1	CCCN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
	10923047	16477	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@@H]2CNC3	10.1021/jm0101545
	CHEMBL123642	16477	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@@H]2CNC3	10.1021/jm0101545
	1971	2846	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	2404	2846	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	4543	2846	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	CHEMBL445	2846	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	DB00540	2846	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	44312870	204554	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
	CHEMBL73082	204554	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
	44323876	206559	0	None	2	4	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
	CHEMBL88870	206559	0	None	2	4	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
	135	2515	43	None	-91	58	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	1796	2515	43	None	-91	58	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	4184	2515	43	None	-91	58	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	CHEMBL6437	2515	43	None	-91	58	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	DB06148	2515	43	None	-91	58	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	10828627	103137	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm991005d
	CHEMBL308090	103137	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm991005d
	15521599	204515	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm991005d
	CHEMBL72794	204515	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm991005d
	10828627	103137	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm9704457
	CHEMBL308090	103137	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm9704457
	15521599	204515	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm9704457
	CHEMBL72794	204515	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm9704457
	10264174	9656	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@H]21	10.1021/jm00002a013
	CHEMBL113053	9656	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@H]21	10.1021/jm00002a013
	70692656	76046	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	CHEMBL2057457	76046	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	70692656	76046	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
	CHEMBL2057457	76046	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
	10031670	12432	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	610	9	2	8	6.5	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3OC)cc1)N(C)CC2	10.1021/np50087a016
	CHEMBL1186148	12432	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	610	9	2	8	6.5	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3OC)cc1)N(C)CC2	10.1021/np50087a016
	CHEMBL451734	12432	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	610	9	2	8	6.5	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3OC)cc1)N(C)CC2	10.1021/np50087a016
	44370651	46720	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1c(Cl)ccc(O)c1-3	10.1021/jm00164a022
	CHEMBL153960	46720	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1c(Cl)ccc(O)c1-3	10.1021/jm00164a022
	3561	19045	39	None	-1	11	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
	CHEMBL1289	19045	39	None	-1	11	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
	14137099	172667	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	638	11	0	8	7.1	COc1cc2c(cc1OC)[C@H](Cc1ccc(OC)c(Oc3ccc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)cc3)c1)N(C)CC2	10.1021/np50087a016
	CHEMBL450147	172667	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	638	11	0	8	7.1	COc1cc2c(cc1OC)[C@H](Cc1ccc(OC)c(Oc3ccc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)cc3)c1)N(C)CC2	10.1021/np50087a016
	CHEMBL507970	172667	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	638	11	0	8	7.1	COc1cc2c(cc1OC)[C@H](Cc1ccc(OC)c(Oc3ccc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)cc3)c1)N(C)CC2	10.1021/np50087a016
	44269131	30880	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	381	2	2	4	3.2	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	CHEMBL13979	30880	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	381	2	2	4	3.2	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	71041800	162717	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	290	7	3	6	2.2	CCC[C@@H](CCO)Nc1nc(N)nc2cc(OC)ccc12	10.1021/acs.jmedchem.8b00643
	CHEMBL4171368	162717	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	290	7	3	6	2.2	CCC[C@@H](CCO)Nc1nc(N)nc2cc(OC)ccc12	10.1021/acs.jmedchem.8b00643
	44285013	153716	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	319	7	0	1	5.4	C(=C\C1CCCN(CCCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
	CHEMBL39818	153716	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	319	7	0	1	5.4	C(=C\C1CCCN(CCCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
	1042	1568	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	148	1568	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	443884	1568	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	CHEMBL119443	1568	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	DB01253	1568	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	10693049	119342	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	412	2	0	2	6.0	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCCC2	10.1021/jm00022a004
	CHEMBL344426	119342	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	412	2	0	2	6.0	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCCC2	10.1021/jm00022a004
	10810927	119270	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	CHEMBL343922	119270	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
	146299	173353	8	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL452776	173353	8	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	44267790	15491	0	None	-	1	Rat	6.2	pIC50	=	6.2	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	431	6	1	10	1.9	Cc1sc2nc(SCCCN3CCN(c4ncccn4)CC3)n(N)c(=O)c2c1C	10.1021/jm950866t
	CHEMBL12177	15491	0	None	-	1	Rat	6.2	pIC50	=	6.2	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	431	6	1	10	1.9	Cc1sc2nc(SCCCN3CCN(c4ncccn4)CC3)n(N)c(=O)c2c1C	10.1021/jm950866t
	118731187	118153	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	613	10	3	7	6.1	CCOc1nc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCC4)c(-c4ccc(F)cn4)n(C)c3c2)ccc1/C=C/C(=O)O	10.1016/j.bmcl.2014.12.078
	CHEMBL3408841	118153	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	613	10	3	7	6.1	CCOc1nc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCC4)c(-c4ccc(F)cn4)n(C)c3c2)ccc1/C=C/C(=O)O	10.1016/j.bmcl.2014.12.078
	10092409	12014	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL1183479	12014	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL299561	12014	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10095594	12336	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL1185501	12336	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL417550	12336	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10364722	99057	0	None	-	1	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL280608	99057	0	None	-	1	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL51888	99057	0	None	-	1	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL3215298	211208	13	None	-6	2	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(C=C[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(C=C[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
	14901811	13505	6	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	155	2	2	2	1.0	NCCc1ccc(F)c(O)c1	10.1021/jm00171a014
	CHEMBL1193777	13505	6	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	155	2	2	2	1.0	NCCc1ccc(F)c(O)c1	10.1021/jm00171a014
	CHEMBL545240	13505	6	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	155	2	2	2	1.0	NCCc1ccc(F)c(O)c1	10.1021/jm00171a014
	10809333	27160	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136630	27160	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	4189	206899	96	None	-25	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206899	96	None	-25	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206899	96	None	-25	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	16104	161893	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00130a006
	CHEMBL415300	161893	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00130a006
	16104	161893	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00164a053
	CHEMBL415300	161893	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00164a053
	44285030	132465	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	291	5	0	1	4.7	C(=C\C1CCCN(CCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
	CHEMBL36979	132465	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	291	5	0	1	4.7	C(=C\C1CCCN(CCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
	23930365	95618	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c3c(c1OC)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1021/jm060959i
	CHEMBL257957	95618	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c3c(c1OC)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1021/jm060959i
	44370725	119526	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(Cl)c(O)c1-3	10.1021/jm00164a022
	CHEMBL345907	119526	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(Cl)c(O)c1-3	10.1021/jm00164a022
	9954899	204440	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
	CHEMBL72292	204440	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
	9954899	204440	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm9704457
	CHEMBL72292	204440	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm9704457
	167715	2856	14	None	-954	5	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
	969	2856	14	None	-954	5	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
	CHEMBL225230	2856	14	None	-954	5	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
	71109986	150609	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
	CHEMBL3955446	150609	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
	9904738	101629	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	309	2	2	3	3.8	CCCN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
	CHEMBL299161	101629	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	309	2	2	3	3.8	CCCN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
	13154798	26739	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	382	5	1	3	4.1	CC(C)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	CHEMBL136262	26739	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	382	5	1	3	4.1	CC(C)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	10026300	167810	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	441	2	0	7	3.3	CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
	CHEMBL430798	167810	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	441	2	0	7	3.3	CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
	10409038	85213	0	None	-41	4	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
	CHEMBL225853	85213	0	None	-41	4	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
	3081681	98486	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	compound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissuecompound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissue	ChEMBL	442	6	0	7	3.4	O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2nsc3ccccc23)CC1	10.1021/jm00107a028
	CHEMBL276175	98486	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	compound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissuecompound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissue	ChEMBL	442	6	0	7	3.4	O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2nsc3ccccc23)CC1	10.1021/jm00107a028
	5249490	15126	1	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1C2CNC3	10.1021/jm0101545
	CHEMBL120995	15126	1	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1C2CNC3	10.1021/jm0101545
	2105	3032	37	None	-537	33	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	47811	3032	37	None	-537	33	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	48	3032	37	None	-537	33	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	CHEMBL531	3032	37	None	-537	33	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	DB01186	3032	37	None	-537	33	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	70690499	76042	0	None	9	2	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057453	76042	0	None	9	2	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
	160597	155051	30	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	3	2.8	c1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
	CHEMBL401798	155051	30	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	3	2.8	c1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
	70682090	76040	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	CHEMBL2057451	76040	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	70682090	76040	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
	CHEMBL2057451	76040	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
	3158	56237	27	None	-2398	20	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL1628227	56237	27	None	-2398	20	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	2601	3751	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
	443951	3751	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
	56	3751	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
	CHEMBL73151	3751	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
	DB13399	3751	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
	13154822	30460	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	418	5	1	5	2.4	CS(=O)(=O)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	CHEMBL139304	30460	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	418	5	1	5	2.4	CS(=O)(=O)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
	6603820	95745	19	None	1	13	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
	CHEMBL25856	95745	19	None	1	13	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
	71474025	145302	0	None	131	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	CHEMBL3913343	145302	0	None	131	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	11539632	70532	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	CHEMBL194837	70532	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	44354823	24542	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	241	1	1	2	2.2	C#CCN1CCCC2Cc3c(O)cccc3CC21	10.1021/jm980284m
	CHEMBL134273	24542	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	241	1	1	2	2.2	C#CCN1CCCC2Cc3c(O)cccc3CC21	10.1021/jm980284m
	16038374	94318	95	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptorDisplacement of [3H]SCH-23390 from dopamine D1 receptor	ChEMBL	357	5	1	4	4.9	COc1cc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc(OC)c1	10.1073/pnas.0611364104
	CHEMBL250699	94318	95	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptorDisplacement of [3H]SCH-23390 from dopamine D1 receptor	ChEMBL	357	5	1	4	4.9	COc1cc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc(OC)c1	10.1073/pnas.0611364104
	10571551	116541	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	375	2	0	2	6.2	CCN1CCc2c(sc3ccccc23)C(c2ccc(Cl)c(Cl)c2)C1	10.1021/jm980156y
	CHEMBL336437	116541	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	375	2	0	2	6.2	CCN1CCc2c(sc3ccccc23)C(c2ccc(Cl)c(Cl)c2)C1	10.1021/jm980156y
	135398745	2893	112	None	-26	66	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	47	2893	112	None	-26	66	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	CHEMBL715	2893	112	None	-26	66	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	DB00334	2893	112	None	-26	66	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	49836386	18518	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	253	2	1	2	3.2	CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1	10.1021/jm100515z
	CHEMBL1275709	18518	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	253	2	1	2	3.2	CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1	10.1021/jm100515z
	44269142	32099	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	CHEMBL14089	32099	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	15115475	26814	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	322	4	1	3	2.9	OCCN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
	CHEMBL136333	26814	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	322	4	1	3	2.9	OCCN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
	12441	51061	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm00164a022
	CHEMBL157912	51061	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm00164a022
	44269091	98393	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	CHEMBL275539	98393	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
	44312604	204428	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	338	1	0	2	4.6	CC1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
	CHEMBL72220	204428	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	338	1	0	2	4.6	CC1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
	133	2479	52	None	-30	43	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	1723	2479	52	None	-30	43	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	28693	2479	52	None	-30	43	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	CHEMBL19215	2479	52	None	-30	43	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	DB13520	2479	52	None	-30	43	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	12441	51061	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm060959i
	CHEMBL157912	51061	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm060959i
	5018	3523	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	943	3523	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	946	3523	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	CHEMBL13668	3523	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	135686415	204553	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm991005d
	CHEMBL73074	204553	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm991005d
	135686415	204553	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm9704457
	CHEMBL73074	204553	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm9704457
	3294	1993	111	None	-	45	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
	71360	1993	111	None	-	45	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
	87	1993	111	None	-	45	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
	CHEMBL14376	1993	111	None	-	45	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
	DB04946	1993	111	None	-	45	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
	10144	138385	46	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	275	0	0	4	3.2	O=C1c2ccccc2-c2c3c(cc4ccnc1c24)OCO3	10.1021/jm060959i
	CHEMBL37736	138385	46	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	275	0	0	4	3.2	O=C1c2ccccc2-c2c3c(cc4ccnc1c24)OCO3	10.1021/jm060959i
	44269092	29055	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	296	0	1	1	4.4	C[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
	CHEMBL13811	29055	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	296	0	1	1	4.4	C[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
	11059058	10059	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
	CHEMBL115444	10059	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
	71110287	146300	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	CHEMBL3921127	146300	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	448537	160226	89	None	-28	25	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	CHEMBL411	160226	89	None	-28	25	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	44312605	204412	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
	CHEMBL72162	204412	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
	13720693	99645	4	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00086a016
	CHEMBL284473	99645	4	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00086a016
	71109897	87484	0	None	7	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
	CHEMBL2334893	87484	0	None	7	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
	10478809	164854	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
	CHEMBL422067	164854	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
	10787201	28701	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	4	0	2	5.9	CCC1(CC)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
	CHEMBL137805	28701	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	4	0	2	5.9	CCC1(CC)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
	44354809	116516	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	3.8	COc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
	CHEMBL336274	116516	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	3.8	COc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
	100	3776	58	None	-16	56	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
	2637	3776	58	None	-16	56	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
	5452	3776	58	None	-16	56	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
	CHEMBL479	3776	58	None	-16	56	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
	DB00679	3776	58	None	-16	56	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
	681	1453	72	None	-97	39	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
	940	1453	72	None	-97	39	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
	947	1453	72	None	-97	39	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
	CHEMBL59	1453	72	None	-97	39	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
	DB00988	1453	72	None	-97	39	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
	442203	174534	5	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1cc2c(cc1OC)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL455633	174534	5	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1cc2c(cc1OC)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	10504100	47710	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membrane	ChEMBL	458	7	1	8	4.2	COc1ccccc1C1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
	CHEMBL154787	47710	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membrane	ChEMBL	458	7	1	8	4.2	COc1ccccc1C1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
	14901825	13056	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	287	7	1	2	3.6	CCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	CHEMBL1190275	13056	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	287	7	1	2	3.6	CCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	CHEMBL540546	13056	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	287	7	1	2	3.6	CCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
	10024943	97361	0	None	-	1	Bovine	4.1	pIC50	=	4.1	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL26975	97361	0	None	-	1	Bovine	4.1	pIC50	=	4.1	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	CHEMBL52485	97361	0	None	-	1	Bovine	4.1	pIC50	=	4.1	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
	10406315	193301	0	None	-	2	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	361	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(Cl)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
	CHEMBL524439	193301	0	None	-	2	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	361	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(Cl)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
	146025813	175563	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	175563	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	44370706	47942	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1cc(Br)cc(O)c1-3	10.1021/jm00164a022
	CHEMBL154989	47942	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1cc(Br)cc(O)c1-3	10.1021/jm00164a022
	10409556	162348	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	414	8	1	5	3.3	COc1cccc2c1CC(CNCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1016/0960-894X(96)00174-6
	CHEMBL416523	162348	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	414	8	1	5	3.3	COc1cccc2c1CC(CNCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1016/0960-894X(96)00174-6
	15657207	206314	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	287	2	2	2	3.7	CNC1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00069a013
	CHEMBL87321	206314	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	287	2	2	2	3.7	CNC1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00069a013
	44269058	31336	0	None	-	1	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
	CHEMBL14022	31336	0	None	-	1	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
	1016	3720	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3720	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3720	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3720	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3720	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3720	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	44370645	119536	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
	CHEMBL346017	119536	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
	1530	2169	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	3827	2169	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	7206	2169	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	CHEMBL534	2169	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	DB00920	2169	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	10522247	26700	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136235	26700	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
	16103	204615	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00130a006
	CHEMBL73538	204615	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00130a006
	16103	204615	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00164a053
	CHEMBL73538	204615	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00164a053
	71454427	78491	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
	CHEMBL2111937	78491	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
	44329358	107497	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
	CHEMBL318714	107497	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
	10833129	27459	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3cccc(F)c3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	CHEMBL136873	27459	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3cccc(F)c3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
	15648963	16862	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	340	2	0	2	5.1	CN1CC=C(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1	10.1021/jm00072a006
	CHEMBL12507	16862	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	340	2	0	2	5.1	CN1CC=C(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1	10.1021/jm00072a006
	70690500	76044	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
	CHEMBL2057455	76044	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
	9804849	67426	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	CHEMBL189118	67426	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	2812	4747	101	None	-32	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	CHEMBL104	4747	101	None	-32	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	44584686	12660	0	None	-	0	Rat	4.0	pIC50	=	4.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@@H](C(=O)c1ccc(O)c(c1)-c1cc(ccc1OC)C[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
	CHEMBL1187479	12660	0	None	-	0	Rat	4.0	pIC50	=	4.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@@H](C(=O)c1ccc(O)c(c1)-c1cc(ccc1OC)C[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
	CHEMBL504303	12660	0	None	-	0	Rat	4.0	pIC50	=	4.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@@H](C(=O)c1ccc(O)c(c1)-c1cc(ccc1OC)C[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
	11543723	189075	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
	CHEMBL51017	189075	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
	176	397	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	397	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	397	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	397	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	397	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	3198	205490	76	None	-31	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205490	76	None	-31	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205490	76	None	-31	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	114876	12761	5	None	-	5	Rat	4.0	pIC50	=	4.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm00101a018
	CHEMBL1188090	12761	5	None	-	5	Rat	4.0	pIC50	=	4.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm00101a018
	CHEMBL545783	12761	5	None	-	5	Rat	4.0	pIC50	=	4.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm00101a018
	135515198	104723	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
	CHEMBL310712	104723	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
	135515198	104723	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
	CHEMBL310712	104723	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
	134	2497	24	None	-263	68	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	1775	2497	24	None	-263	68	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	9681	2497	24	None	-263	68	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	CHEMBL1065	2497	24	None	-263	68	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	DB00247	2497	24	None	-263	68	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	11778475	163271	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3ccc(O)c(O)c3CC[C@H]21	10.1021/jm00002a013
	CHEMBL418791	163271	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3ccc(O)c(O)c3CC[C@H]21	10.1021/jm00002a013
	66572162	75666	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	363	6	1	3	5.2	OC(CCN1CC=C(Cc2ccccc2)CC1)c1cc2ccccc2s1	10.1016/j.ejmech.2012.04.030
	CHEMBL2047561	75666	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	363	6	1	3	5.2	OC(CCN1CC=C(Cc2ccccc2)CC1)c1cc2ccccc2s1	10.1016/j.ejmech.2012.04.030
	10907460	9796	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL113956	9796	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	25053021	109645	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
	CHEMBL322574	109645	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
	25053021	109645	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	CHEMBL322574	109645	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	70686343	76043	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057454	76043	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	135508767	204102	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
	CHEMBL70377	204102	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
	13891896	188907	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	297	2	2	4	2.8	COc1c(O)c2c3c(c1OC)CCN[C@@H]3Cc1ccccc1-2	10.1021/jm060959i
	CHEMBL508011	188907	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	297	2	2	4	2.8	COc1c(O)c2c3c(c1OC)CCN[C@@H]3Cc1ccccc1-2	10.1021/jm060959i
	135508767	204102	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
	CHEMBL70377	204102	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
	3082777	168298	10	None	-	1	Human	9.8	pKd	=	9.8	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2C(c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00119a003
	CHEMBL434215	168298	10	None	-	1	Human	9.8	pKd	=	9.8	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2C(c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00119a003
	164612037	185353	0	None	-144	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	CHEMBL4860528	185353	0	None	-144	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	168290235	192944	0	None	-1513	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5201074	192944	0	None	-1513	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222491	192944	0	None	-1513	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	168294767	192995	0	None	-457	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5207281	192995	0	None	-457	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222802	192995	0	None	-457	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	168295528	193007	0	None	-338	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5206565	193007	0	None	-338	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222872	193007	0	None	-338	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	44366049	43425	0	None	-	1	Human	9.6	pKd	=	9.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
	CHEMBL150800	43425	0	None	-	1	Human	9.6	pKd	=	9.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
	2869	4121	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
	60	4121	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
	60857	4121	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
	CHEMBL1185	4121	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
	DB00315	4121	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
	3036864	202731	19	None	-2	28	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
	CHEMBL1256645	202731	19	None	-2	28	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
	CHEMBL1814790	202731	19	None	-2	28	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
	CHEMBL62	202731	19	None	-2	28	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
	129244	118645	7	None	-	1	Rat	8.9	pKd	=	8.9	Binding	In vitro binding affinity to the rat striatal homogenateIn vitro binding affinity to the rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
	CHEMBL2114388	118645	7	None	-	1	Rat	8.9	pKd	=	8.9	Binding	In vitro binding affinity to the rat striatal homogenateIn vitro binding affinity to the rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
	CHEMBL34170	118645	7	None	-	1	Rat	8.9	pKd	=	8.9	Binding	In vitro binding affinity to the rat striatal homogenateIn vitro binding affinity to the rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
	118736406	118930	0	None	3	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	673	16	7	7	2.7	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423404	118930	0	None	3	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	673	16	7	7	2.7	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
	16731521	85426	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	630	10	4	5	3.5	CC(C)[C@H](NC(=O)[C@H](CCC1CCCCC1)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
	CHEMBL226639	85426	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	630	10	4	5	3.5	CC(C)[C@H](NC(=O)[C@H](CCC1CCCCC1)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
	118736409	118933	0	None	-1	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	693	16	6	6	3.3	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)c(F)c1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423407	118933	0	None	-1	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	693	16	6	6	3.3	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)c(F)c1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
	6852376	91570	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
	CHEMBL1467585	91570	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
	CHEMBL24077	91570	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
	CHEMBL503958	91570	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
	118736412	118937	0	None	-6	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423410	118937	0	None	-6	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	118736405	118929	0	None	-9	3	Human	4.8	pKd	=	4.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423403	118929	0	None	-9	3	Human	4.8	pKd	=	4.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	118736413	118938	0	None	-2	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423411	118938	0	None	-2	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	167715	2856	14	None	-194	5	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
	969	2856	14	None	-194	5	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
	CHEMBL225230	2856	14	None	-194	5	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
	1153	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	12668023	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	30026874	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	30026875	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	3341	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	6603851	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	933	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	939	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	985	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	CHEMBL1160786	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	CHEMBL1161520	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	CHEMBL588	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	DB00800	1615	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	118736408	118932	0	None	1	3	Human	5.7	pKd	=	5.7	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	696	16	7	6	3.5	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423406	118932	0	None	1	3	Human	5.7	pKd	=	5.7	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	696	16	7	6	3.5	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
	5311428	100079	9	None	-32	2	Rat	6.7	pKd	=	6.7	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	CHEMBL1744078	100079	9	None	-32	2	Rat	6.7	pKd	=	6.7	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	CHEMBL287504	100079	9	None	-32	2	Rat	6.7	pKd	=	6.7	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	10088113	162253	6	None	-4	2	Rat	8.6	pKd	=	8.6	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	CHEMBL1744079	162253	6	None	-4	2	Rat	8.6	pKd	=	8.6	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	CHEMBL416401	162253	6	None	-4	2	Rat	8.6	pKd	=	8.6	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	118736412	118937	0	None	-6	2	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423410	118937	0	None	-6	2	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	681	1453	72	None	-154	39	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
	940	1453	72	None	-154	39	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
	947	1453	72	None	-154	39	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
	CHEMBL59	1453	72	None	-154	39	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
	DB00988	1453	72	None	-154	39	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
	118736402	118926	0	None	-5	4	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	659	11	5	6	2.4	CCCC[C@H](NC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423400	118926	0	None	-5	4	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	659	11	5	6	2.4	CCCC[C@H](NC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
	1153	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	12668023	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	30026874	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	30026875	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	3341	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	6603851	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	933	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	939	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	985	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	CHEMBL1160786	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	CHEMBL1161520	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	CHEMBL588	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	DB00800	1615	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
	118736404	118928	0	None	-2	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	18	7	7	3.5	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423402	118928	0	None	-2	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	18	7	7	3.5	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	118736413	118938	0	None	-2	2	Human	4.5	pKd	=	4.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423411	118938	0	None	-2	2	Human	4.5	pKd	=	4.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
	118736411	118935	0	None	-1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	788	22	7	7	3.8	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423409	118935	0	None	-1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	788	22	7	7	3.8	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
	118736407	118931	0	None	1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	17	7	7	3.5	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423405	118931	0	None	1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	17	7	7	3.5	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
	118736403	118927	0	None	-6	3	Human	4.4	pKd	=	4.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	786	22	8	8	3.4	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423401	118927	0	None	-6	3	Human	4.4	pKd	=	4.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	786	22	8	8	3.4	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
	10452020	118249	3	None	10	3	Human	6.4	pKd	=	6.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm950447w
	CHEMBL34095	118249	3	None	10	3	Human	6.4	pKd	=	6.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm950447w
	118736410	118934	0	None	-1	3	Human	5.4	pKd	=	5.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	772	17	6	7	3.1	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
	CHEMBL3423408	118934	0	None	-1	3	Human	5.4	pKd	=	5.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	772	17	6	7	3.1	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
	122132	202541	17	None	-87	4	Human	5.3	pKd	=	5.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm950447w
	CHEMBL611801	202541	17	None	-87	4	Human	5.3	pKd	=	5.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm950447w
	1960	2838	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	439260	2838	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	505	2838	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	CHEMBL1437	2838	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	DB00368	2838	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	1028	289	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	139148732	289	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	479	289	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	5816	289	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	CHEMBL679	289	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	DB00668	289	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
	16731518	142257	0	None	26	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	628	9	4	5	2.5	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
	CHEMBL388509	142257	0	None	26	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	628	9	4	5	2.5	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
	228	444	28	None	-35	24	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
	33	444	28	None	-35	24	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
	6005	444	28	None	-35	24	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
	CHEMBL53	444	28	None	-35	24	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
	DB00714	444	28	None	-35	24	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
	16732431	144006	0	None	-34	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	735	11	4	7	3.3	CN1C[C@H](C(=O)N[C@@H](Cc2ccc([N+](=O)[O-])cc2)C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCCC(C(N)=O)C2)C=C2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm060947x
	CHEMBL390299	144006	0	None	-34	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	735	11	4	7	3.3	CN1C[C@H](C(=O)N[C@@H](Cc2ccc([N+](=O)[O-])cc2)C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCCC(C(N)=O)C2)C=C2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm060947x
	16732899	168681	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
	CHEMBL436797	168681	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
	16731520	142326	0	None	-	1	Human	5.1	pKd	=	5.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
	CHEMBL388732	142326	0	None	-	1	Human	5.1	pKd	=	5.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
	5	139	72	None	-23442	55	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
	5202	139	72	None	-23442	55	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
	CHEMBL39	139	72	None	-23442	55	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
	DB08839	139	72	None	-23442	55	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
	4350931	169289	44	None	63	7	Rat	10.1	pKi	=	10.1	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
	CHEMBL441618	169289	44	None	63	7	Rat	10.1	pKi	=	10.1	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
	127026236	138093	0	None	1	3	Rat	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	450	8	1	4	3.9	O=C(NCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
	CHEMBL3763331	138093	0	None	1	3	Rat	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	450	8	1	4	3.9	O=C(NCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
	CHEMBL3765893	138093	0	None	1	3	Rat	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	450	8	1	4	3.9	O=C(NCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
	3036864	202731	19	None	-26	28	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1256645	202731	19	None	-26	28	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1814790	202731	19	None	-26	28	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL62	202731	19	None	-26	28	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	3036864	202731	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
	CHEMBL1256645	202731	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
	CHEMBL1814790	202731	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
	CHEMBL62	202731	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
	3036864	202731	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL1256645	202731	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL1814790	202731	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL62	202731	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	3036864	202731	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL1256645	202731	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL1814790	202731	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL62	202731	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	3036864	202731	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
	CHEMBL1256645	202731	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
	CHEMBL1814790	202731	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
	CHEMBL62	202731	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
	3036864	202731	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
	CHEMBL62	202731	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
	11465618	102371	23	None	1	19	Human	9.9	pKi	=	9.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2020.127563
	CHEMBL3039528	102371	23	None	1	19	Human	9.9	pKi	=	9.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2020.127563
	CHEMBL5191141	102371	23	None	1	19	Human	9.9	pKi	=	9.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2020.127563
	3036864	202731	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
	CHEMBL62	202731	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
	3036864	202731	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1256645	202731	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1814790	202731	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL62	202731	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	3036864	202731	19	None	-26	28	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1256645	202731	19	None	-26	28	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1814790	202731	19	None	-26	28	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL62	202731	19	None	-26	28	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	3036864	202731	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL1256645	202731	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL1814790	202731	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL62	202731	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
	3036864	202731	19	None	-2	28	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
	CHEMBL1256645	202731	19	None	-2	28	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
	CHEMBL1814790	202731	19	None	-2	28	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
	CHEMBL62	202731	19	None	-2	28	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
	11154178	200203	0	None	64	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	412	4	1	3	4.6	CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1	10.1016/j.bmcl.2009.12.100
	CHEMBL596824	200203	0	None	64	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	412	4	1	3	4.6	CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1	10.1016/j.bmcl.2009.12.100
	162657549	180960	0	None	630	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	355	1	1	3	5.3	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
	CHEMBL4758723	180960	0	None	630	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	355	1	1	3	5.3	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
	46231926	200556	0	None	12	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	446	4	1	4	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL599135	200556	0	None	12	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	446	4	1	4	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	46231992	200620	0	None	398	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	389	1	1	2	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL599528	200620	0	None	398	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	389	1	1	2	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	3036864	202731	19	None	-2	28	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL62	202731	19	None	-2	28	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
	14896355	26802	0	None	10	3	Rat	9.6	pKi	=	9.6	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(Br)c2)C1	10.1016/s0960-894x(00)00185-2
	CHEMBL13632	26802	0	None	10	3	Rat	9.6	pKi	=	9.6	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(Br)c2)C1	10.1016/s0960-894x(00)00185-2
	1243	3591	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1021/jm00115a012
	944	3591	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1021/jm00115a012
	CHEMBL324017	3591	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1021/jm00115a012
	3038603	101838	8	None	2	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
	CHEMBL300647	101838	8	None	2	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
	3036864	202731	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
	CHEMBL1256645	202731	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
	CHEMBL1814790	202731	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
	CHEMBL62	202731	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
	3036864	202731	19	None	-2	28	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL62	202731	19	None	-2	28	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
	3036864	202731	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
	CHEMBL1256645	202731	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
	CHEMBL1814790	202731	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
	CHEMBL62	202731	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
	11269330	201470	0	None	34	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	390	1	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL605127	201470	0	None	34	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	390	1	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	3039881	174233	10	None	4	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
	CHEMBL45491	174233	10	None	4	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
	11558055	73123	1	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
	CHEMBL1204122	73123	1	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
	CHEMBL201170	73123	1	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
	3036864	202731	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL1256645	202731	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL1814790	202731	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL62	202731	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	11558055	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL1204122	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL201170	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	11558055	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL1204122	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL201170	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
	11558055	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
	CHEMBL1204122	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
	CHEMBL201170	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
	3036864	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	CHEMBL62	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	11558055	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL1204122	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL201170	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	14787973	102640	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1cccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)c1	10.1021/jm00170a025
	CHEMBL304535	102640	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1cccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)c1	10.1021/jm00170a025
	3036864	202731	19	None	2	28	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
	CHEMBL1256645	202731	19	None	2	28	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
	CHEMBL1814790	202731	19	None	2	28	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
	CHEMBL62	202731	19	None	2	28	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
	3036864	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL62	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	11558055	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
	CHEMBL1204122	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
	CHEMBL201170	73123	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
	46231993	200384	0	None	562	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	407	1	1	2	5.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL598104	200384	0	None	562	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	407	1	1	2	5.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	3036864	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
	CHEMBL62	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
	3036864	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL62	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	3036864	202731	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
	CHEMBL1256645	202731	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
	CHEMBL1814790	202731	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
	CHEMBL62	202731	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
	3036864	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
	CHEMBL62	202731	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
	11595240	140163	0	None	-5	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	CHEMBL380464	140163	0	None	-5	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	162655154	180749	0	None	204	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
	CHEMBL4756254	180749	0	None	204	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
	44320357	206376	0	None	1202	2	Rat	9.3	pKi	=	9.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87734	206376	0	None	1202	2	Rat	9.3	pKi	=	9.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	11235174	200358	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NS(C)(=O)=O)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL597909	200358	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NS(C)(=O)=O)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	11374299	200585	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	448	5	1	4	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C3CCC3)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL599282	200585	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	448	5	1	4	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C3CCC3)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
	46231588	201238	0	None	12022	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	408	4	1	4	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL603901	201238	0	None	12022	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	408	4	1	4	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
	3036864	202731	19	None	-2	28	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
	CHEMBL1256645	202731	19	None	-2	28	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
	CHEMBL1814790	202731	19	None	-2	28	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
	CHEMBL62	202731	19	None	-2	28	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
	44439943	93337	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL245570	93337	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2006.11.093
	11465618	102371	23	None	1	19	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL3039528	102371	23	None	1	19	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL5191141	102371	23	None	1	19	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	44439943	93337	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2008.04.081
	CHEMBL245570	93337	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2008.04.081
	86346162	132414	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	433	3	1	4	4.2	Cc1cc(Oc2ncccc2I)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697581	132414	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	433	3	1	4	4.2	Cc1cc(Oc2ncccc2I)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	10088113	162253	6	None	4	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL1744079	162253	6	None	4	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL416401	162253	6	None	4	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
	11488247	200616	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	470	5	1	4	4.5	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL599487	200616	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	470	5	1	4	4.5	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
	46232135	200301	0	None	85	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	428	1	2	2	6.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc5[nH]ccc5c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL597503	200301	0	None	85	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	428	1	2	2	6.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc5[nH]ccc5c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	46231994	200385	0	None	5	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	414	1	1	3	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL598105	200385	0	None	5	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	414	1	1	3	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	46231784	201315	0	None	2	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	329	0	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL604314	201315	0	None	2	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	329	0	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	46231995	201511	0	None	7	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	434	2	1	4	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL605339	201511	0	None	7	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	434	2	1	4	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	44268809	98237	0	None	46	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
	CHEMBL274577	98237	0	None	46	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
	24873463	148019	0	None	3467	2	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	557	10	0	5	6.0	O=C(CCCN1CCN2CC3C(CC2C1)c1ccccc1N3CCCC(=O)c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
	CHEMBL393466	148019	0	None	3467	2	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	557	10	0	5	6.0	O=C(CCCN1CCN2CC3C(CC2C1)c1ccccc1N3CCCC(=O)c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
	46231645	200328	0	None	776	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	518	6	1	3	7.2	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(Cc3ccccc3)c3ccc(F)cc3F)cc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL597702	200328	0	None	776	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	518	6	1	3	7.2	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(Cc3ccccc3)c3ccc(F)cc3F)cc2)C1	10.1016/j.bmcl.2009.12.100
	46231709	200684	0	None	1548	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)Nc4c(Cl)cccc4Cl)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL599977	200684	0	None	1548	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)Nc4c(Cl)cccc4Cl)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	11452916	200806	0	None	7	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	CHEMBL600986	200806	0	None	7	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	44268693	23317	0	None	16	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2Br)C1	10.1016/s0960-894x(00)00185-2
	CHEMBL13325	23317	0	None	16	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2Br)C1	10.1016/s0960-894x(00)00185-2
	3036864	202731	19	None	-2	28	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
	CHEMBL1256645	202731	19	None	-2	28	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
	CHEMBL1814790	202731	19	None	-2	28	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
	CHEMBL62	202731	19	None	-2	28	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
	46232067	200266	0	None	16	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	2	1	3	5.7	CN(C)c1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
	CHEMBL597310	200266	0	None	16	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	2	1	3	5.7	CN(C)c1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
	46232066	201233	0	None	8	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	1	3	5.7	COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
	CHEMBL603872	201233	0	None	8	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	1	3	5.7	COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
	46232134	201293	0	None	125	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	2	3	5.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc(CO)cc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL604176	201293	0	None	125	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	2	3	5.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc(CO)cc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	3036864	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
	CHEMBL62	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
	3036864	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
	CHEMBL62	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
	10516818	25619	0	None	2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL135197	25619	0	None	2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	14787971	170048	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccccc1[C@H]1CN(C)CCc2cc(Cl)c(O)cc21	10.1021/jm00170a025
	CHEMBL444321	170048	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccccc1[C@H]1CN(C)CCc2cc(Cl)c(O)cc21	10.1021/jm00170a025
	3036864	202731	19	None	-2	28	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
	CHEMBL1256645	202731	19	None	-2	28	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
	CHEMBL1814790	202731	19	None	-2	28	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
	CHEMBL62	202731	19	None	-2	28	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
	242	469	124	None	-74	52	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
	34	469	124	None	-74	52	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
	60795	469	124	None	-74	52	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
	CHEMBL1112	469	124	None	-74	52	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
	DB01238	469	124	None	-74	52	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
	11681599	75144	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1016/j.bmcl.2008.04.081
	CHEMBL203637	75144	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1016/j.bmcl.2008.04.081
	44439942	151841	0	None	4	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2[nH]c3c(c2c1)CCN(C)CCc1ccccc1C3	10.1016/j.bmcl.2006.11.093
	CHEMBL396560	151841	0	None	4	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2[nH]c3c(c2c1)CCN(C)CCc1ccccc1C3	10.1016/j.bmcl.2006.11.093
	11681599	75144	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL203637	75144	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	10802788	168214	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL433652	168214	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	10802788	168214	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL433652	168214	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	3036864	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
	CHEMBL1256645	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
	CHEMBL1814790	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
	CHEMBL62	202731	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
	46231541	200165	0	None	4	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	370	4	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNC3CCC3)cc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL596622	200165	0	None	4	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	370	4	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNC3CCC3)cc2)C1	10.1016/j.bmcl.2009.12.100
	107930	1517	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
	3304	1517	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
	CHEMBL298406	1517	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
	DB12273	1517	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
	149506840	183124	0	None	120	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	371	1	1	3	5.8	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
	CHEMBL4795230	183124	0	None	120	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	371	1	1	3	5.8	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
	46232065	200236	0	None	346	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	425	1	1	2	5.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cc(F)cc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL597100	200236	0	None	346	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	425	1	1	2	5.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cc(F)cc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	46216855	200355	0	None	2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	395	1	1	3	5.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL597900	200355	0	None	2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	395	1	1	3	5.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	15111050	13316	0	None	707	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	357	3	1	2	4.3	C=CCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL1192259	13316	0	None	707	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	357	3	1	2	4.3	C=CCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL543473	13316	0	None	707	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	357	3	1	2	4.3	C=CCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
	130844	13170	14	None	512	2	Human	9.1	pKi	=	9.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)C(c2ccccc2)C1	10.1021/jm00116a004
	CHEMBL1191103	13170	14	None	512	2	Human	9.1	pKi	=	9.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)C(c2ccccc2)C1	10.1021/jm00116a004
	CHEMBL543398	13170	14	None	512	2	Human	9.1	pKi	=	9.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)C(c2ccccc2)C1	10.1021/jm00116a004
	71451380	81208	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	435	3	5	6	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1.O=C(O)/C(O)=C(/O)C(=O)O	10.1016/j.bmc.2012.08.058
	CHEMBL2158641	81208	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	435	3	5	6	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1.O=C(O)/C(O)=C(/O)C(=O)O	10.1016/j.bmc.2012.08.058
	6852376	91570	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL1467585	91570	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL24077	91570	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL503958	91570	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
	167715	2856	14	None	-194	5	Human	9.0	pKi	=	9	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	969	2856	14	None	-194	5	Human	9.0	pKi	=	9	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	CHEMBL225230	2856	14	None	-194	5	Human	9.0	pKi	=	9	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	11393666	192962	0	None	-2	19	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5201983	192962	0	None	-2	19	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5222597	192962	0	None	-2	19	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	46231927	201513	0	None	2	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	3	1	4	5.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL605354	201513	0	None	2	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	3	1	4	5.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	13805900	43979	0	None	-2	6	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	261	5	1	2	3.6	CCCN(CCC)[C@@H]1Cc2cccc(O)c2C[C@H]1C	10.1021/jm020990u
	CHEMBL15136	43979	0	None	-2	6	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	261	5	1	2	3.6	CCCN(CCC)[C@@H]1Cc2cccc(O)c2C[C@H]1C	10.1021/jm020990u
	162646534	179559	0	None	123	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	362	1	1	4	5.0	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(C#N)cc32)CCN1C	10.1016/j.bmcl.2020.127563
	CHEMBL4742056	179559	0	None	123	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	362	1	1	4	5.0	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(C#N)cc32)CCN1C	10.1016/j.bmcl.2020.127563
	1242	3586	27	None	-5	18	Human	9.0	pKi	=	9.0	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
	935	3586	27	None	-5	18	Human	9.0	pKi	=	9.0	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
	CHEMBL286080	3586	27	None	-5	18	Human	9.0	pKi	=	9.0	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
	133538	3592	24	None	-1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2008.09.049
	8443	3592	24	None	-1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2008.09.049
	CHEMBL574558	3592	24	None	-1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2008.09.049
	107930	1517	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
	3304	1517	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
	CHEMBL298406	1517	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
	DB12273	1517	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
	5018	3523	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	943	3523	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	946	3523	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	CHEMBL13668	3523	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	107930	1517	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
	3304	1517	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
	CHEMBL298406	1517	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
	DB12273	1517	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
	15111051	13338	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	313	3	1	2	4.2	C=CCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL1192465	13338	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	313	3	1	2	4.2	C=CCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL543704	13338	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	313	3	1	2	4.2	C=CCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
	13697621	13709	0	None	1148	2	Human	8.9	pKi	=	8.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	347	1	2	3	3.5	CN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
	CHEMBL1195188	13709	0	None	1148	2	Human	8.9	pKi	=	8.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	347	1	2	3	3.5	CN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
	CHEMBL554009	13709	0	None	1148	2	Human	8.9	pKi	=	8.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	347	1	2	3	3.5	CN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
	1153	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	12668023	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	30026874	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	30026875	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	3341	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	6603851	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	933	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	939	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	985	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	CHEMBL1160786	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	CHEMBL1161520	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	CHEMBL588	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	DB00800	1615	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	3036864	202731	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL1256645	202731	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL1814790	202731	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL62	202731	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	5018	3523	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	943	3523	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	946	3523	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	CHEMBL13668	3523	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
	134139606	146323	0	None	288	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	419	3	2	5	3.9	CCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3921278	146323	0	None	288	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	419	3	2	5	3.9	CCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	3036864	202731	19	None	-5	28	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
	CHEMBL1256645	202731	19	None	-5	28	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
	CHEMBL1814790	202731	19	None	-5	28	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
	CHEMBL62	202731	19	None	-5	28	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
	10638646	26183	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL135735	26183	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
	11486421	201171	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	400	2	2	4	4.5	CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	CHEMBL603485	201171	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	400	2	2	4	4.5	CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	3036864	202731	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL1256645	202731	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL1814790	202731	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL62	202731	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
	142405815	181140	0	None	-10	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	365	2	1	3	5.7	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
	CHEMBL4760903	181140	0	None	-10	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	365	2	1	3	5.7	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
	11223303	200807	0	None	4	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	CHEMBL600987	200807	0	None	4	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	14787975	102205	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1	10.1021/jm00170a025
	CHEMBL303012	102205	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1	10.1021/jm00170a025
	162646218	179452	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
	CHEMBL4740880	179452	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
	122324	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	6077	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	CHEMBL86931	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	122324	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	6077	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	CHEMBL86931	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	44415569	165910	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	CHEMBL425069	165910	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	44415569	165910	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	CHEMBL425069	165910	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	46231849	201395	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	356	1	2	4	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL604732	201395	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	356	1	2	4	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	3036864	202731	19	None	-2	28	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
	CHEMBL1256645	202731	19	None	-2	28	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
	CHEMBL1814790	202731	19	None	-2	28	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
	CHEMBL62	202731	19	None	-2	28	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
	129244	118645	7	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
	CHEMBL2114388	118645	7	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
	CHEMBL34170	118645	7	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
	10638646	26183	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL135735	26183	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
	37461	17102	14	None	-2	8	Rat	8.7	pKi	=	8.7	Binding	Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm9911478
	CHEMBL1255588	17102	14	None	-2	8	Rat	8.7	pKi	=	8.7	Binding	Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm9911478
	46231925	201355	0	None	5	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	384	3	1	4	4.4	CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
	CHEMBL604525	201355	0	None	5	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	384	3	1	4	4.4	CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
	73671785	129395	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	3	2	6	2.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3671278	129395	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	3	2	6	2.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	4350931	169289	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
	CHEMBL441618	169289	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
	10656804	116533	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL336366	116533	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
	107930	1517	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
	3304	1517	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
	CHEMBL298406	1517	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
	DB12273	1517	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
	107930	1517	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
	3304	1517	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
	CHEMBL298406	1517	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
	DB12273	1517	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
	4350931	169289	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
	CHEMBL441618	169289	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
	4350931	169289	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL441618	169289	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	4350931	169289	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL441618	169289	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
	4350931	169289	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1039/C5MD00258C
	CHEMBL441618	169289	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1039/C5MD00258C
	12765746	102253	4	None	-18	10	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL303313	102253	4	None	-18	10	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	12765746	102253	4	None	-18	10	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	CHEMBL303313	102253	4	None	-18	10	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	9797664	166213	1	None	-4	3	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	331	1	0	4	3.8	CN1CCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	CHEMBL426763	166213	1	None	-4	3	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	331	1	0	4	3.8	CN1CCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	107930	1517	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
	3304	1517	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
	CHEMBL298406	1517	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
	DB12273	1517	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
	133538	3592	24	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	8443	3592	24	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	CHEMBL574558	3592	24	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	12765746	102253	4	None	-18	10	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL303313	102253	4	None	-18	10	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	4106	2485	22	None	-5	34	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
	5358812	2485	22	None	-5	34	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
	89	2485	22	None	-5	34	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
	CHEMBL93240	2485	22	None	-5	34	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
	44348383	16271	0	None	-10	2	Rat	8.7	pKi	=	8.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1021/jm9706832
	CHEMBL122536	16271	0	None	-10	2	Rat	8.7	pKi	=	8.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1021/jm9706832
	135398745	2893	112	None	-26	66	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
	47	2893	112	None	-26	66	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
	CHEMBL715	2893	112	None	-26	66	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
	DB00334	2893	112	None	-26	66	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
	15937726	165125	0	None	177	2	Rat	8.0	pKi	=	8	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	293	1	1	2	4.2	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL422796	165125	0	None	177	2	Rat	8.0	pKi	=	8	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	293	1	1	2	4.2	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
	44579030	189657	0	None	10	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	377	7	0	3	5.7	CCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
	CHEMBL515342	189657	0	None	10	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	377	7	0	3	5.7	CCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
	44415558	80133	0	None	93	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4n3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213443	80133	0	None	93	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4n3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	44415657	168717	0	None	17	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	4	1	7	4.9	CCOc1csc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
	CHEMBL437112	168717	0	None	17	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	4	1	7	4.9	CCOc1csc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
	117773683	132416	0	None	-	1	Human	8.0	pKi	=	8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	403	5	1	6	3.5	Cc1cc(Oc2nccc(C)c2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697583	132416	0	None	-	1	Human	8.0	pKi	=	8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	403	5	1	6	3.5	Cc1cc(Oc2nccc(C)c2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	56594534	70571	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO	10.1021/jm200676f
	CHEMBL1949728	70571	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO	10.1021/jm200676f
	90140327	129386	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]c(C)c23)cc1	nan
	CHEMBL3671269	129386	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]c(C)c23)cc1	nan
	74223724	129391	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3671274	129391	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	74223826	129411	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
	CHEMBL3671293	129411	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
	11637457	73058	1	None	1	5	Human	8.0	pKi	=	8.0	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
	CHEMBL201093	73058	1	None	1	5	Human	8.0	pKi	=	8.0	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
	86764102	132453	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1ccnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)cc2)c1Cl	nan
	CHEMBL3697619	132453	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1ccnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)cc2)c1Cl	nan
	135398745	2893	112	None	-26	66	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	47	2893	112	None	-26	66	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	CHEMBL715	2893	112	None	-26	66	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	DB00334	2893	112	None	-26	66	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	11271099	204634	0	None	-501	4	Rat	7.0	pKi	=	7	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	458	9	2	5	4.3	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(N)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
	CHEMBL73665	204634	0	None	-501	4	Rat	7.0	pKi	=	7	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	458	9	2	5	4.3	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(N)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
	15937722	115198	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	294	1	1	3	3.1	CN1CCc2cc(Cl)c(O)cc2C(N2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL334650	115198	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	294	1	1	3	3.1	CN1CCc2cc(Cl)c(O)cc2C(N2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
	49782398	17420	0	None	-138	5	Pig	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	471	6	1	3	5.7	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
	CHEMBL1257688	17420	0	None	-138	5	Pig	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	471	6	1	3	5.7	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
	6603820	95745	19	None	1	13	Rat	7.0	pKi	=	7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL25856	95745	19	None	1	13	Rat	7.0	pKi	=	7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
	15711850	13207	0	None	-1	5	Goldfish	7.0	pKi	=	7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
	CHEMBL1191350	13207	0	None	-1	5	Goldfish	7.0	pKi	=	7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
	CHEMBL542436	13207	0	None	-1	5	Goldfish	7.0	pKi	=	7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
	242	469	124	None	-281	52	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	34	469	124	None	-281	52	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	60795	469	124	None	-281	52	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	CHEMBL1112	469	124	None	-281	52	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	DB01238	469	124	None	-281	52	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	135398737	955	93	None	-44	92	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	38	955	93	None	-44	92	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	722	955	93	None	-44	92	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	CHEMBL42	955	93	None	-44	92	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	DB00363	955	93	None	-44	92	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	2337	3232	77	None	-53	63	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	50	3232	77	None	-53	63	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	5002	3232	77	None	-53	63	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	CHEMBL716	3232	77	None	-53	63	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	DB01224	3232	77	None	-53	63	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	2389	3306	118	None	-489	68	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	5073	3306	118	None	-489	68	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	96	3306	118	None	-489	68	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	CHEMBL85	3306	118	None	-489	68	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	DB00734	3306	118	None	-489	68	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	17449900	139517	13	None	-3548	6	Pig	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	348	5	0	5	3.2	COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
	CHEMBL379602	139517	13	None	-3548	6	Pig	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	348	5	0	5	3.2	COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
	137633863	156601	0	None	-436	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4069145	156601	0	None	-436	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	44372154	54195	0	None	-11	4	Bovine	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	434	4	0	4	5.4	Cc1nn2c(-c3ccc(F)cc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
	CHEMBL160749	54195	0	None	-11	4	Bovine	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	434	4	0	4	5.4	Cc1nn2c(-c3ccc(F)cc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
	9864676	127782	0	None	-58	5	Bovine	6.0	pKi	=	6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	380	6	0	3	4.5	O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL366388	127782	0	None	-58	5	Bovine	6.0	pKi	=	6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	380	6	0	3	4.5	O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	15115530	12886	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	659	3	7	9	6.4	O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N/C(S)=N\c3ccc(C4CNCCc5cc(O)c(O)cc54)cc3)cc21	10.1021/jm00115a012
	CHEMBL1189085	12886	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	659	3	7	9	6.4	O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N/C(S)=N\c3ccc(C4CNCCc5cc(O)c(O)cc54)cc3)cc21	10.1021/jm00115a012
	CHEMBL538023	12886	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	659	3	7	9	6.4	O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N/C(S)=N\c3ccc(C4CNCCc5cc(O)c(O)cc54)cc3)cc21	10.1021/jm00115a012
	44339879	172258	0	None	-186	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
	CHEMBL447476	172258	0	None	-186	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
	10357869	4852	0	None	-158	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3cccc3-c3cnco3)CC2)cc1	10.1016/s0960-894x(99)00540-5
	CHEMBL104453	4852	0	None	-158	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3cccc3-c3cnco3)CC2)cc1	10.1016/s0960-894x(99)00540-5
	44412458	139269	3	None	-3090	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	316	4	0	4	3.6	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)nn2)C1	10.1016/j.bmcl.2006.02.075
	CHEMBL379177	139269	3	None	-3090	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	316	4	0	4	3.6	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)nn2)C1	10.1016/j.bmcl.2006.02.075
	45112568	198783	0	None	-229	3	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
	CHEMBL583422	198783	0	None	-229	3	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
	145980271	166468	0	None	-19	16	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL4278465	166468	0	None	-19	16	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	145986752	167252	0	None	-23	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
	CHEMBL4293307	167252	0	None	-23	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
	10633305	35964	1	None	-28	2	Bovine	4.0	pKi	=	4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2ccc(C)cc2C)C1	10.1021/jm9708700
	CHEMBL144302	35964	1	None	-28	2	Bovine	4.0	pKi	=	4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2ccc(C)cc2C)C1	10.1021/jm9708700
	44329093	207689	0	None	-309	3	Bovine	4.0	pKi	=	4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@@H]1CCn2ccc(CO)c2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL95618	207689	0	None	-309	3	Bovine	4.0	pKi	=	4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@@H]1CCn2ccc(CO)c2C1	10.1016/s0960-894x(01)00564-9
	44304814	202849	0	None	-16	4	Bovine	4.0	pKi	=	4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	505	8	1	5	5.9	COc1c(-c2nc(CNC[C@@H]3CCN(Cc4ccccc4)C3)co2)cc(Br)c2ccccc12	10.1016/s0960-894x(00)00405-4
	CHEMBL62601	202849	0	None	-16	4	Bovine	4.0	pKi	=	4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	505	8	1	5	5.9	COc1c(-c2nc(CNC[C@@H]3CCN(Cc4ccccc4)C3)co2)cc(Br)c2ccccc12	10.1016/s0960-894x(00)00405-4
	71109993	143222	0	None	-	1	Human	6.0	pKi	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
	CHEMBL3896617	143222	0	None	-	1	Human	6.0	pKi	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
	228	444	28	None	-4	24	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
	33	444	28	None	-4	24	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
	6005	444	28	None	-4	24	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
	CHEMBL53	444	28	None	-4	24	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
	DB00714	444	28	None	-4	24	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
	228	444	28	None	-30	24	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
	33	444	28	None	-30	24	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
	6005	444	28	None	-30	24	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
	CHEMBL53	444	28	None	-30	24	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
	DB00714	444	28	None	-30	24	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
	74223776	129406	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1C#N	nan
	CHEMBL3671289	129406	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1C#N	nan
	28417	40009	49	None	-1	12	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
	CHEMBL1479	40009	49	None	-1	12	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
	15711865	13143	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
	CHEMBL1190906	13143	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
	CHEMBL541838	13143	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
	3246545	202451	1	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL1573438	202451	1	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL611207	202451	1	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	44415394	141808	0	None	15	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	471	3	1	5	4.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)/C=C/c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL386424	141808	0	None	15	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	471	3	1	5	4.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)/C=C/c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	13864380	206409	1	None	4	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87958	206409	1	None	4	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
	13864381	208321	3	None	4	4	Rat	6.0	pKi	=	6.0	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL542683	208321	3	None	4	4	Rat	6.0	pKi	=	6.0	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL99361	208321	3	None	4	4	Rat	6.0	pKi	=	6.0	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	10637496	112857	0	None	-58	3	Rat	6.0	pKi	=	6.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	2	0	2	4.0	CCc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	CHEMBL331005	112857	0	None	-58	3	Rat	6.0	pKi	=	6.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	2	0	2	4.0	CCc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	44405995	72967	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
	CHEMBL200802	72967	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
	56593482	3910	3	None	-954	9	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	7650	3910	3	None	-954	9	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	CHEMBL2165119	3910	3	None	-954	9	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	156018236	177888	0	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	377	4	1	3	4.9	C=CCN1CCc2cc(OC)c(O)cc2C(c2c(Cl)cccc2Cl)C1	10.1016/j.bmcl.2020.127305
	CHEMBL4645139	177888	0	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	377	4	1	3	4.9	C=CCN1CCc2cc(OC)c(O)cc2C(c2c(Cl)cccc2Cl)C1	10.1016/j.bmcl.2020.127305
	154706030	176521	1	None	-50	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4580817	176521	1	None	-50	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4597188	176521	1	None	-50	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	76325156	106363	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
	CHEMBL3115585	106363	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
	CHEMBL3139393	106363	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
	12050197	100847	0	None	-79	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	457	6	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
	CHEMBL293645	100847	0	None	-79	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	457	6	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
	10570422	164881	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	6	2	3	4.0	CNCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL422267	164881	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	6	2	3	4.0	CNCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	15627832	98506	0	None	-6	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	345	0	2	3	3.6	CN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	CHEMBL276326	98506	0	None	-6	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	345	0	2	3	3.6	CN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	13646434	124628	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
	CHEMBL1743799	124628	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
	CHEMBL36416	124628	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
	70692652	76035	0	None	8	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057441	76035	0	None	8	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	72708059	92167	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425369	92167	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	161665	172561	35	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
	CHEMBL448891	172561	35	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
	1353	1898	93	None	-38	86	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
	3559	1898	93	None	-38	86	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
	86	1898	93	None	-38	86	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
	CHEMBL54	1898	93	None	-38	86	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
	DB00502	1898	93	None	-38	86	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
	72708059	92167	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425369	92167	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	45112462	196943	0	None	-831	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
	CHEMBL566533	196943	0	None	-831	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
	154706123	176264	1	None	-134	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4593394	176264	1	None	-134	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4595145	176264	1	None	-134	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	11724078	41677	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cccnc3Oc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
	CHEMBL149240	41677	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cccnc3Oc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
	154706513	176562	1	None	-16	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
	CHEMBL4440698	176562	1	None	-16	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
	CHEMBL4597532	176562	1	None	-16	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
	3117	207818	103	None	-2	16	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	CHEMBL964	207818	103	None	-2	16	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	44448066	94846	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	10.1021/jm060959i
	CHEMBL253948	94846	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	10.1021/jm060959i
	154704141	176655	1	None	-46	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	3	5.0	CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4561808	176655	1	None	-46	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	3	5.0	CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4598299	176655	1	None	-46	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	3	5.0	CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	117774721	132419	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	5	1	6	2.8	Cc1c(-c2ccc(Oc3ncccc3OC(F)F)cc2)n(C)c(=O)[nH]c1=O	nan
	CHEMBL3697586	132419	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	5	1	6	2.8	Cc1c(-c2ccc(Oc3ncccc3OC(F)F)cc2)n(C)c(=O)[nH]c1=O	nan
	112500032	132444	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)cnc(=O)n1C	nan
	CHEMBL3697610	132444	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)cnc(=O)n1C	nan
	10333842	98403	1	None	-50	8	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
	CHEMBL27559	98403	1	None	-50	8	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
	76325156	106363	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
	CHEMBL3115585	106363	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
	CHEMBL3139393	106363	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
	9951964	206335	0	None	-22	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm00042a009
	CHEMBL87458	206335	0	None	-22	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm00042a009
	44415644	141796	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	583	4	1	5	7.3	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4N(NC(=O)c4ccccc4Cl)c4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
	CHEMBL386336	141796	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	583	4	1	5	7.3	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4N(NC(=O)c4ccccc4Cl)c4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
	10490043	113694	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960189i
	CHEMBL332332	113694	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960189i
	44386623	61025	0	None	-1	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	376	3	0	4	4.2	COc1c(Cl)c2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
	CHEMBL176356	61025	0	None	-1	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	376	3	0	4	4.2	COc1c(Cl)c2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
	1212	1649	50	None	-51	66	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1649	50	None	-51	66	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1649	50	None	-51	66	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1649	50	None	-51	66	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1649	50	None	-51	66	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	44415633	79978	0	None	8	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	7	5.1	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
	CHEMBL212807	79978	0	None	8	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	7	5.1	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
	44415578	141478	0	None	57	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL384500	141478	0	None	57	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	134151737	152950	0	None	12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	5	2	5	3.9	CCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3975220	152950	0	None	12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	5	2	5	3.9	CCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	127031424	138844	0	None	5	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	6	1	5	4.2	CCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
	CHEMBL3781840	138844	0	None	5	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	6	1	5	4.2	CCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
	75201901	166401	19	None	-1	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166401	19	None	-1	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	44370173	48455	1	None	-18	2	Bovine	7.0	pKi	=	7.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	331	6	2	4	4.0	CCCN(CCc1cccs1)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
	CHEMBL155613	48455	1	None	-18	2	Bovine	7.0	pKi	=	7.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	331	6	2	4	4.0	CCCN(CCc1cccs1)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
	75201901	166401	19	None	-1	24	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166401	19	None	-1	24	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	122189393	123222	0	None	-20	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	455	6	0	7	4.0	Clc1cccc(N2CCN(CCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
	CHEMBL3613879	123222	0	None	-20	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	455	6	0	7	4.0	Clc1cccc(N2CCN(CCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
	122189394	123223	0	None	-354	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	7	0	7	4.4	Clc1cccc(N2CCN(CCCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
	CHEMBL3613880	123223	0	None	-354	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	7	0	7	4.4	Clc1cccc(N2CCN(CCCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
	21302486	109773	0	None	-117	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	379	5	1	4	3.9	O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCN3)c1ccc(F)cc1	10.1021/jm401958n
	CHEMBL3233143	109773	0	None	-117	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	379	5	1	4	3.9	O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCN3)c1ccc(F)cc1	10.1021/jm401958n
	10092819	16741	0	None	-1412	12	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm025558r
	CHEMBL124444	16741	0	None	-1412	12	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm025558r
	11133602	30744	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
	CHEMBL139600	30744	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
	44276404	99050	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL28054	99050	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	44276557	99288	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL282136	99288	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	11761412	116925	0	None	-2290	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	411	9	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)/C=C/c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.09.142
	CHEMBL338606	116925	0	None	-2290	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	411	9	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)/C=C/c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.09.142
	10490043	113694	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm060959i
	CHEMBL332332	113694	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm060959i
	71459761	84051	0	None	-181	7	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	540	7	0	5	6.1	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	CHEMBL2207642	84051	0	None	-181	7	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	540	7	0	5	6.1	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	137635685	155981	0	None	-38	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	417	7	1	7	3.6	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12	10.1021/acs.jmedchem.7b00363
	CHEMBL4061986	155981	0	None	-38	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	417	7	1	7	3.6	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12	10.1021/acs.jmedchem.7b00363
	25072633	159197	0	None	-1584	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4098803	159197	0	None	-1584	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	118709166	113385	0	None	-19	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	25	0	8	12.9	O=C(CCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318838	113385	0	None	-19	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	25	0	8	12.9	O=C(CCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	164615845	185166	0	None	-1	6	Human	6.0	pKi	=	6.0	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
	CHEMBL4857492	185166	0	None	-1	6	Human	6.0	pKi	=	6.0	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
	10833953	31094	0	None	-1445	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cc2c1	10.1021/jm0009989
	CHEMBL140006	31094	0	None	-1445	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cc2c1	10.1021/jm0009989
	44380697	58063	0	None	-61	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	CHEMBL167414	58063	0	None	-61	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	44380685	58705	0	None	-77	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	CHEMBL168566	58705	0	None	-77	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	44380815	58980	0	None	-234	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
	CHEMBL169193	58980	0	None	-234	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
	44264682	97289	0	None	-2754	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)c1	10.1016/s0960-894x(98)00692-1
	CHEMBL269202	97289	0	None	-2754	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)c1	10.1016/s0960-894x(98)00692-1
	15508243	5271	22	None	-7	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	366	3	0	2	3.9	Ic1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
	CHEMBL106635	5271	22	None	-7	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	366	3	0	2	3.9	Ic1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
	25099153	187229	0	None	-257039	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	436	9	2	5	4.7	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	CHEMBL492664	187229	0	None	-257039	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	436	9	2	5	4.7	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	45270021	195141	0	None	-158	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	335	3	0	5	3.0	Cc1cc2nc(C)c(CN3CCN(c4ccccc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
	CHEMBL550392	195141	0	None	-158	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	335	3	0	5	3.0	Cc1cc2nc(C)c(CN3CCN(c4ccccc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
	45272580	196433	0	None	-165	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cnc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
	CHEMBL563109	196433	0	None	-165	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cnc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
	102262219	140034	0	None	-22908	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	CHEMBL3800400	140034	0	None	-22908	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	137655029	158922	0	None	-2691	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	452	8	1	9	2.6	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12	10.1016/j.bmc.2017.08.037
	CHEMBL4095881	158922	0	None	-2691	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	452	8	1	9	2.6	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12	10.1016/j.bmc.2017.08.037
	137657427	159535	0	None	-9772	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	476	7	3	6	3.5	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	CHEMBL4102628	159535	0	None	-9772	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	476	7	3	6	3.5	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	10361512	54409	0	None	-4786	5	Bovine	5.0	pKi	=	5.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	365	3	0	5	3.5	Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
	CHEMBL160932	54409	0	None	-4786	5	Bovine	5.0	pKi	=	5.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	365	3	0	5	3.5	Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
	154706590	176285	1	None	-58	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4590839	176285	1	None	-58	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4595264	176285	1	None	-58	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
	71110301	92169	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425371	92169	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	44415368	79574	0	None	17	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	465	4	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCC3CCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL211461	79574	0	None	17	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	465	4	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCC3CCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	14198586	201810	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1016/j.bmc.2009.05.079
	CHEMBL60706	201810	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1016/j.bmc.2009.05.079
	156013666	177255	0	None	-10	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	3	1	4	3.6	COc1cc2c3c(c1OC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4636318	177255	0	None	-10	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	3	1	4	3.6	COc1cc2c3c(c1OC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	2726	916	68	None	-36	73	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	916	68	None	-36	73	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	916	68	None	-36	73	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	916	68	None	-36	73	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	916	68	None	-36	73	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	154704536	176423	1	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4467528	176423	1	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4596340	176423	1	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	154703875	176424	1	None	-87	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4586582	176424	1	None	-87	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4596341	176424	1	None	-87	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	11335419	67070	1	None	-11	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	7	0	2	4.1	c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1	10.1021/jm049720x
	CHEMBL187367	67070	1	None	-11	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	7	0	2	4.1	c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1	10.1021/jm049720x
	74223726	129393	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	10.1021/acs.jmedchem.8b01767
	CHEMBL3671276	129393	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	10.1021/acs.jmedchem.8b01767
	74223726	129393	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
	CHEMBL3671276	129393	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
	10497993	168450	0	None	2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL43514	168450	0	None	2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
	3038495	705	37	None	-616	19	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
	7625	705	37	None	-616	19	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
	CHEMBL25236	705	37	None	-616	19	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
	136074293	203034	0	None	-3	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1cnc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm00067a009
	CHEMBL63590	203034	0	None	-3	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1cnc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm00067a009
	45481842	198038	0	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	3	1	2	3.8	CCCCC1c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
	CHEMBL574112	198038	0	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	3	1	2	3.8	CCCCC1c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
	56589561	70572	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO	10.1021/jm200676f
	CHEMBL1949729	70572	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO	10.1021/jm200676f
	135398737	955	93	None	-83	92	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
	38	955	93	None	-83	92	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
	722	955	93	None	-83	92	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
	CHEMBL42	955	93	None	-83	92	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
	DB00363	955	93	None	-83	92	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
	242	469	124	None	-281	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	34	469	124	None	-281	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	60795	469	124	None	-281	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	CHEMBL1112	469	124	None	-281	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	DB01238	469	124	None	-281	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	242	469	124	None	-281	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	34	469	124	None	-281	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	60795	469	124	None	-281	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	CHEMBL1112	469	124	None	-281	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	DB01238	469	124	None	-281	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	76325154	106379	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
	CHEMBL3115580	106379	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
	CHEMBL3139475	106379	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
	154703647	176341	1	None	-20	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4450429	176341	1	None	-20	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4595728	176341	1	None	-20	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	135398737	955	93	None	-83	92	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
	38	955	93	None	-83	92	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
	722	955	93	None	-83	92	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
	CHEMBL42	955	93	None	-83	92	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
	DB00363	955	93	None	-83	92	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
	156016177	177630	0	None	-114	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
	CHEMBL4641502	177630	0	None	-114	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
	12049520	101038	5	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	319	4	0	4	3.7	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)co2)cc1	10.1016/s0960-894x(00)00405-4
	CHEMBL294780	101038	5	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	319	4	0	4	3.7	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)co2)cc1	10.1016/s0960-894x(00)00405-4
	44593524	184032	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2008.05.077
	CHEMBL482276	184032	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2008.05.077
	76325154	106379	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
	CHEMBL3115580	106379	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
	CHEMBL3139475	106379	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
	44448062	94819	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
	CHEMBL253737	94819	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
	117774133	132392	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	5	4.1	Cc1cc(Oc2ncc(Cl)cc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697559	132392	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	5	4.1	Cc1cc(Oc2ncc(Cl)cc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	90644065	111634	0	None	-8	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	5	0	4	4.2	Clc1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL3286429	111634	0	None	-8	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	5	0	4	4.2	Clc1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
	53318565	58571	0	None	-6	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
	CHEMBL1684134	58571	0	None	-6	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
	10000788	47963	0	None	-41	3	Rat	5.9	pKi	=	5.9	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	395	6	1	4	3.9	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCN(c3ccccc3OC)CC1)CC2	10.1016/0960-894X(95)00076-6
	CHEMBL155006	47963	0	None	-41	3	Rat	5.9	pKi	=	5.9	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	395	6	1	4	3.9	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCN(c3ccccc3OC)CC1)CC2	10.1016/0960-894X(95)00076-6
	10832461	51234	0	None	-1	2	Rat	4.9	pKi	=	4.9	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)c2c(c1)CCN(C)C2Cc1ccccc1O	10.1021/jm991034o
	CHEMBL158067	51234	0	None	-1	2	Rat	4.9	pKi	=	4.9	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)c2c(c1)CCN(C)C2Cc1ccccc1O	10.1021/jm991034o
	86763998	132448	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697614	132448	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	135398745	2893	112	None	-23	66	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	47	2893	112	None	-23	66	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	CHEMBL715	2893	112	None	-23	66	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	DB00334	2893	112	None	-23	66	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	91899760	129421	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	1	5	4.3	Cc1cc(Oc2nccc3n[nH]cc23)c(F)cc1-c1c(C)ncnc1C	nan
	CHEMBL3671302	129421	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	1	5	4.3	Cc1cc(Oc2nccc3n[nH]cc23)c(F)cc1-c1c(C)ncnc1C	nan
	12304090	87479	36	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@H]21	10.1016/j.bmc.2012.12.016
	CHEMBL2334886	87479	36	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@H]21	10.1016/j.bmc.2012.12.016
	135398745	2893	112	None	-26	66	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
	47	2893	112	None	-26	66	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
	CHEMBL715	2893	112	None	-26	66	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
	DB00334	2893	112	None	-26	66	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
	168289523	191475	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysisDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysis	ChEMBL	422	5	1	2	6.0	FC(F)(F)c1cccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)c1	10.1016/j.bmcl.2022.128615
	CHEMBL5193761	191475	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysisDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysis	ChEMBL	422	5	1	2	6.0	FC(F)(F)c1cccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)c1	10.1016/j.bmcl.2022.128615
	10276451	200262	37	None	-12022	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
	CHEMBL2112910	200262	37	None	-12022	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
	CHEMBL59725	200262	37	None	-12022	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
	10531	1408	21	None	-218	24	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	121	1408	21	None	-218	24	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	888	1408	21	None	-218	24	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL1732	1408	21	None	-218	24	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00320	1408	21	None	-218	24	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	2435	3563	83	None	-43	49	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
	60149	3563	83	None	-43	49	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
	98	3563	83	None	-43	49	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
	CHEMBL12713	3563	83	None	-43	49	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
	DB06144	3563	83	None	-43	49	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
	25141414	182457	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	5	0	3	4.9	CCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
	CHEMBL478671	182457	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	5	0	3	4.9	CCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
	44415721	80013	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	605	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212936	80013	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	605	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	44415703	79792	0	None	537	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)c(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL212077	79792	0	None	537	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)c(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	44415688	80142	0	None	30	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213477	80142	0	None	30	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	134143833	150491	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	355	4	2	5	3.6	CCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3954556	150491	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	355	4	2	5	3.6	CCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	127031403	138709	0	None	4	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	381	5	1	5	3.9	COc1cc2c(cc1O)C1Cc3ccc(OCC4CC4)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
	CHEMBL3780184	138709	0	None	4	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	381	5	1	5	3.9	COc1cc2c(cc1O)C1Cc3ccc(OCC4CC4)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
	10733562	146989	0	None	25	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL39266	146989	0	None	25	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
	9819042	13125	3	None	23	2	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	333	1	3	3	3.1	Oc1cc2c(c(Br)c1O)CCNCC2c1ccccc1	10.1021/jm00116a004
	CHEMBL1190761	13125	3	None	23	2	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	333	1	3	3	3.1	Oc1cc2c(c(Br)c1O)CCNCC2c1ccccc1	10.1021/jm00116a004
	CHEMBL541559	13125	3	None	23	2	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	333	1	3	3	3.1	Oc1cc2c(c(Br)c1O)CCNCC2c1ccccc1	10.1021/jm00116a004
	1241	100151	24	None	-2	8	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00116a004
	CHEMBL288090	100151	24	None	-2	8	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00116a004
	CHEMBL552611	100151	24	None	-2	8	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00116a004
	117773867	132428	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	1	4	4.9	Cc1cc(Oc2nccc(C)c2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697594	132428	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	1	4	4.9	Cc1cc(Oc2nccc(C)c2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	6917970	3665	61	None	-1	34	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	8370	3665	61	None	-1	34	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	CHEMBL487387	3665	61	None	-1	34	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	127031422	138693	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	4	1	5	3.5	CCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
	CHEMBL3779928	138693	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	4	1	5	3.5	CCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
	14198584	198246	0	None	12	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00118a012
	CHEMBL57579	198246	0	None	12	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00118a012
	117773559	132458	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	416	3	2	5	3.7	Cc1c(-c2ccc(Oc3ncccc3C(F)(F)F)c3[nH]ccc23)n(C)c(=O)[nH]c1=O	nan
	CHEMBL3697624	132458	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	416	3	2	5	3.7	Cc1c(-c2ccc(Oc3ncccc3C(F)(F)F)c3[nH]ccc23)n(C)c(=O)[nH]c1=O	nan
	10005244	111324	0	None	7	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	476	5	1	3	5.9	CN(C)c1ccc(/C=C/CN2CCc3cc(Br)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	CHEMBL326927	111324	0	None	7	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	476	5	1	3	5.9	CN(C)c1ccc(/C=C/CN2CCc3cc(Br)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	44323876	206559	0	None	2	4	Rat	6.9	pKi	=	6.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
	CHEMBL88870	206559	0	None	2	4	Rat	6.9	pKi	=	6.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
	1353	1898	93	None	-38	86	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
	3559	1898	93	None	-38	86	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
	86	1898	93	None	-38	86	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
	CHEMBL54	1898	93	None	-38	86	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
	DB00502	1898	93	None	-38	86	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
	117773696	132400	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	6	2.7	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1F	nan
	CHEMBL3697567	132400	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	6	2.7	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1F	nan
	86764101	132452	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
	CHEMBL3697618	132452	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
	276	3487	50	None	-81	13	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
	5312149	3487	50	None	-81	13	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
	CHEMBL431298	3487	50	None	-81	13	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
	11575479	94714	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
	CHEMBL253096	94714	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
	1353	1898	93	None	-38	86	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
	3559	1898	93	None	-38	86	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
	86	1898	93	None	-38	86	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
	CHEMBL54	1898	93	None	-38	86	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
	DB00502	1898	93	None	-38	86	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
	118709178	113321	0	None	-69	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1154	32	0	17	9.5	O=C(CCc1cn(CCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3317465	113321	0	None	-69	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1154	32	0	17	9.5	O=C(CCc1cn(CCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	122189392	123221	0	None	-54	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	441	5	0	7	3.6	Clc1cccc(N2CCN(CCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
	CHEMBL3613878	123221	0	None	-54	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	441	5	0	7	3.6	Clc1cccc(N2CCN(CCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
	71458071	79471	0	None	-102	6	Bovine	5.9	pKi	=	5.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(02)00316-5
	CHEMBL2113718	79471	0	None	-102	6	Bovine	5.9	pKi	=	5.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(02)00316-5
	6603820	95745	19	None	-4	13	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9800292
	CHEMBL25856	95745	19	None	-4	13	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9800292
	6603954	202582	2	None	-81	3	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm9800292
	CHEMBL612083	202582	2	None	-81	3	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm9800292
	11068912	30833	0	None	-39	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	CHEMBL139722	30833	0	None	-39	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	11057969	33241	0	None	-1778	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
	CHEMBL141845	33241	0	None	-1778	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
	44360992	119378	0	None	-134	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1	10.1021/jm025558r
	CHEMBL344677	119378	0	None	-134	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1	10.1021/jm025558r
	11036640	121121	0	None	-29	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	CHEMBL357684	121121	0	None	-29	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	44264642	204780	0	None	-398	4	Bovine	5.9	pKi	=	5.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
	CHEMBL7506	204780	0	None	-398	4	Bovine	5.9	pKi	=	5.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
	56833463	68307	0	None	-602	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	578	17	1	9	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
	CHEMBL1916552	68307	0	None	-602	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	578	17	1	9	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
	137643951	158235	0	None	-831	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	8	1	7	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4088639	158235	0	None	-831	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	8	1	7	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	56837635	69279	0	None	-3981	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1129	44	2	17	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928132	69279	0	None	-3981	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1129	44	2	17	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	118709164	113383	0	None	-199	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	902	22	0	8	11.7	O=C(CCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318836	113383	0	None	-199	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	902	22	0	8	11.7	O=C(CCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	44371932	119622	0	None	-467	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	354	4	0	5	3.1	O=Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
	CHEMBL346805	119622	0	None	-467	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	354	4	0	5	3.1	O=Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
	10404144	205279	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(02)00316-5
	CHEMBL7927	205279	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(02)00316-5
	10404144	205279	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm015522j
	CHEMBL7927	205279	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm015522j
	44380785	120777	0	None	-363	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
	CHEMBL355566	120777	0	None	-363	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
	10404144	205279	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	CHEMBL7927	205279	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	10404144	205279	23	None	-2187	10	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm060166w
	CHEMBL7927	205279	23	None	-2187	10	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm060166w
	44340097	9408	0	None	-4365	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	CHEMBL111749	9408	0	None	-4365	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	45270861	195057	0	None	-33	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	353	3	0	5	3.1	Cc1cc2nc(C)c(CN3CCN(c4ccc(F)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
	CHEMBL549638	195057	0	None	-33	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	353	3	0	5	3.1	Cc1cc2nc(C)c(CN3CCN(c4ccc(F)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
	681	1453	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
	940	1453	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
	947	1453	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
	CHEMBL59	1453	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
	DB00988	1453	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
	137651322	157451	0	None	-13489	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	465	8	2	9	2.2	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12	10.1016/j.bmc.2017.08.037
	CHEMBL4079375	157451	0	None	-13489	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	465	8	2	9	2.2	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12	10.1016/j.bmc.2017.08.037
	137640189	156929	0	None	-15848	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	466	7	3	7	2.6	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	CHEMBL4072780	156929	0	None	-15848	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	466	7	3	7	2.6	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	681	1453	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
	940	1453	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
	947	1453	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
	CHEMBL59	1453	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
	DB00988	1453	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
	107995	97097	20	None	-28840	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmc.2007.07.017
	29982233	97097	20	None	-28840	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmc.2007.07.017
	CHEMBL267723	97097	20	None	-28840	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmc.2007.07.017
	44329282	169091	0	None	-19	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL440143	169091	0	None	-19	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
	10404144	205279	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
	CHEMBL7927	205279	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
	10247720	13022	1	None	-794	5	Bovine	4.9	pKi	=	4.9	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	320	4	1	4	2.2	c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(01)00484-x
	CHEMBL1190042	13022	1	None	-794	5	Bovine	4.9	pKi	=	4.9	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	320	4	1	4	2.2	c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(01)00484-x
	CHEMBL540039	13022	1	None	-794	5	Bovine	4.9	pKi	=	4.9	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	320	4	1	4	2.2	c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(01)00484-x
	10474964	130445	0	None	-8511	7	Bovine	4.9	pKi	=	4.9	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL368061	130445	0	None	-8511	7	Bovine	4.9	pKi	=	4.9	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL5206021	130445	0	None	-8511	7	Bovine	4.9	pKi	=	4.9	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	10404144	205279	23	None	-4466	10	Human	4.9	pKi	=	4.9	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/acs.jmedchem.7b00151
	CHEMBL7927	205279	23	None	-4466	10	Human	4.9	pKi	=	4.9	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/acs.jmedchem.7b00151
	45481841	198037	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(Cl)c(O)cc21	10.1016/j.bmc.2009.05.079
	CHEMBL574111	198037	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(Cl)c(O)cc21	10.1016/j.bmc.2009.05.079
	90142280	167272	1	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	CHEMBL4293757	167272	1	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	15711855	13380	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	CHEMBL1192799	13380	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	CHEMBL544099	13380	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	13838742	99373	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
	CHEMBL282710	99373	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
	117773223	132425	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	350	4	2	5	2.6	Cc1cc(Oc2ncccc2C(N)=O)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697591	132425	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	350	4	2	5	2.6	Cc1cc(Oc2ncccc2C(N)=O)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	25129807	103267	0	None	-63	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	366	3	2	2	4.8	O[C@@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
	CHEMBL3084502	103267	0	None	-63	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	366	3	2	2	4.8	O[C@@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
	91899762	129426	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cn[nH]c(=O)c1C	nan
	CHEMBL3671307	129426	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cn[nH]c(=O)c1C	nan
	491	192	9	None	-151356	12	Rat	4.9	pKi	=	4.9	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
	9891167	192	9	None	-151356	12	Rat	4.9	pKi	=	4.9	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
	CHEMBL13856	192	9	None	-151356	12	Rat	4.9	pKi	=	4.9	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
	2284	3160	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	4926	3160	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	7281	3160	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	CHEMBL564	3160	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	DB00420	3160	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	44415582	138965	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	444	1	0	4	5.3	Cc1ccccc1C(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	CHEMBL378543	138965	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	444	1	0	4	5.3	Cc1ccccc1C(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	681	1453	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
	940	1453	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
	947	1453	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
	CHEMBL59	1453	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
	DB00988	1453	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
	44241581	13989	0	None	-81	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	373	2	3	4	4.6	CCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL1197218	13989	0	None	-81	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	373	2	3	4	4.6	CCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL562935	13989	0	None	-81	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	373	2	3	4	4.6	CCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	3032727	13444	1	None	-562	2	Rat	6.9	pKi	=	6.9	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	281	1	2	3	3.2	CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
	CHEMBL1193245	13444	1	None	-562	2	Rat	6.9	pKi	=	6.9	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	281	1	2	3	3.2	CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
	CHEMBL544618	13444	1	None	-562	2	Rat	6.9	pKi	=	6.9	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	281	1	2	3	3.2	CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
	74223828	129417	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	4	1	6	3.8	COc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
	CHEMBL3671299	129417	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	4	1	6	3.8	COc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
	10519436	11194	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL1178784	11194	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL41238	11194	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	10664137	162731	0	None	10	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL417164	162731	0	None	10	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	15711851	13508	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
	CHEMBL1193797	13508	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
	CHEMBL545264	13508	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
	9838572	63423	0	None	-23	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	279	1	0	3	2.6	CN1CCN(C2=Cc3ccccc3Cn3cccc32)CC1	10.1021/jm049629t
	CHEMBL179775	63423	0	None	-23	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	279	1	0	3	2.6	CN1CCN(C2=Cc3ccccc3Cn3cccc32)CC1	10.1021/jm049629t
	10072800	96633	4	None	-6	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	384	4	0	5	4.7	O=C1c2ccsc2CC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
	CHEMBL263790	96633	4	None	-6	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	384	4	0	5	4.7	O=C1c2ccsc2CC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
	CHEMBL554199	96633	4	None	-6	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	384	4	0	5	4.7	O=C1c2ccsc2CC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
	12050193	203173	0	None	-2	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	443	5	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
	CHEMBL64325	203173	0	None	-2	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	443	5	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
	12050199	100785	0	None	-32	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	7	1	5	4.9	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL293225	100785	0	None	-32	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	7	1	5	4.9	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
	10068602	100175	1	None	-4677	3	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	384	6	0	4	3.1	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
	CHEMBL28831	100175	1	None	-4677	3	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	384	6	0	4	3.1	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
	71528209	86943	0	None	-1949	7	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
	CHEMBL2323582	86943	0	None	-1949	7	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
	57398351	70129	0	None	-13	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	347	6	0	2	5.1	Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940406	70129	0	None	-13	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	347	6	0	2	5.1	Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
	10801923	177740	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	269	2	2	3	2.7	COc1cc2c(cc1O)C(c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL4642805	177740	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	269	2	2	3	2.7	COc1cc2c(cc1O)C(c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
	44555445	199906	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)Cc1ccccc1C2	10.1016/j.bmc.2009.08.028
	CHEMBL594789	199906	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)Cc1ccccc1C2	10.1016/j.bmc.2009.08.028
	127027739	137959	0	None	-11220	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	382	7	1	6	1.7	O=C(NCCCN1CCN(Cc2ccc3c(c2)OCO3)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
	CHEMBL3764390	137959	0	None	-11220	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	382	7	1	6	1.7	O=C(NCCCN1CCN(Cc2ccc3c(c2)OCO3)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
	60167166	75266	0	None	-41	8	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL2037430	75266	0	None	-41	8	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
	441383	20301	57	None	-12	17	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	CHEMBL1306	20301	57	None	-12	17	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	154705038	176622	1	None	-38	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.2	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4584481	176622	1	None	-38	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.2	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4598001	176622	1	None	-38	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.2	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
	145967904	165073	0	None	-11	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	247	6	1	2	3.8	CCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4227192	165073	0	None	-11	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	247	6	1	2	3.8	CCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	145988180	165207	0	None	-10	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	10	1	2	5.3	CCCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4229178	165207	0	None	-10	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	10	1	2	5.3	CCCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	72699716	115163	0	None	-16	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344459	115163	0	None	-16	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	44326751	108588	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm981094e
	CHEMBL320572	108588	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm981094e
	CHEMBL539544	108588	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm981094e
	24949690	181582	0	None	-1819	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
	CHEMBL477200	181582	0	None	-1819	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
	154705015	176490	1	None	-295	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4454380	176490	1	None	-295	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4596929	176490	1	None	-295	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4576555	213994	5	None	-1	19	Human	5.9	pKi	=	5.9	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
	9930475	206267	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm981094e
	CHEMBL87026	206267	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm981094e
	9930475	206267	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm00042a009
	CHEMBL87026	206267	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm00042a009
	91899761	129423	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	317	3	1	5	3.8	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
	CHEMBL3671304	129423	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	317	3	1	5	3.8	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
	15937725	117079	0	None	158	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	279	1	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C(C2CCCC2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL339342	117079	0	None	158	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	279	1	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C(C2CCCC2)C1	10.1016/S0960-894X(00)80155-9
	44415615	139510	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	CHEMBL379560	139510	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	44415507	80258	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
	CHEMBL214016	80258	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
	10710466	156391	0	None	11	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL40667	156391	0	None	11	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	74223725	129392	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C	nan
	CHEMBL3671275	129392	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C	nan
	117774412	132429	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.5	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)F	nan
	CHEMBL3697595	132429	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.5	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)F	nan
	44281202	100377	3	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	379	1	1	2	3.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	CHEMBL290118	100377	3	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	379	1	1	2	3.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
	44320061	106005	0	None	75	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313304	106005	0	None	75	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	17755866	142859	1	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm070388+
	CHEMBL389356	142859	1	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm070388+
	681	1453	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
	940	1453	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
	947	1453	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
	CHEMBL59	1453	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
	DB00988	1453	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
	15115517	9681	0	None	-426	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL113196	9681	0	None	-426	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	6852376	91570	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
	CHEMBL1467585	91570	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
	CHEMBL24077	91570	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
	CHEMBL503958	91570	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
	2865	4112	73	None	-114	54	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
	59	4112	73	None	-114	54	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
	60854	4112	73	None	-114	54	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
	CHEMBL708	4112	73	None	-114	54	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
	DB00246	4112	73	None	-114	54	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
	146025727	171661	0	None	-4	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171661	0	None	-4	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	44415686	79950	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	7	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212700	79950	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	7	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	24800527	155696	0	None	-4	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	1	3	3.5	CCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
	CHEMBL405369	155696	0	None	-4	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	1	3	3.5	CCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
	57403525	70125	0	None	-85	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940402	70125	0	None	-85	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	118709159	113378	0	None	-21	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	832	17	0	8	9.7	O=C(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318831	113378	0	None	-21	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	832	17	0	8	9.7	O=C(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	2337	3232	77	None	-53	63	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
	50	3232	77	None	-53	63	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
	5002	3232	77	None	-53	63	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
	CHEMBL716	3232	77	None	-53	63	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
	DB01224	3232	77	None	-53	63	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
	44403219	71875	0	None	-1174	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)nc1	10.1016/j.bmcl.2005.07.037
	CHEMBL197162	71875	0	None	-1174	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)nc1	10.1016/j.bmcl.2005.07.037
	10448562	115094	1	None	12	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL334350	115094	1	None	12	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	16105549	67756	0	None	-2884	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1	10.1021/jm0611152
	CHEMBL1908879	67756	0	None	-2884	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1	10.1021/jm0611152
	CHEMBL221640	67756	0	None	-2884	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1	10.1021/jm0611152
	71459759	84042	0	None	-81	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	432	4	0	3	5.5	COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	CHEMBL2207633	84042	0	None	-81	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	432	4	0	3	5.5	COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	44567686	192043	0	None	-1	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	265	1	0	2	3.4	COc1cc2c3c(c1)-c1ccccc1C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.06.016
	CHEMBL520262	192043	0	None	-1	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	265	1	0	2	3.4	COc1cc2c3c(c1)-c1ccccc1C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.06.016
	53327663	66449	0	None	-134	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	342	3	3	5	2.9	CN1CCc2cc(SCCN)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	CHEMBL1852239	66449	0	None	-134	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	342	3	3	5	2.9	CN1CCc2cc(SCCN)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	CHEMBL3215641	66449	0	None	-134	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	342	3	3	5	2.9	CN1CCc2cc(SCCN)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	137643309	158391	0	None	-1174	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccn2ncc(C=O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4090208	158391	0	None	-1174	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccn2ncc(C=O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	122181326	121841	0	None	-426	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	413	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.12.012
	CHEMBL3590077	121841	0	None	-426	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	413	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.12.012
	122181329	121844	0	None	-4168	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	394	10	1	2	4.6	CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590080	121844	0	None	-4168	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	394	10	1	2	4.6	CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	57402787	69166	0	None	-371	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	977	28	2	17	4.4	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1926700	69166	0	None	-371	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	977	28	2	17	4.4	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
	9995904	31189	4	None	-14454	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm060166w
	CHEMBL140099	31189	4	None	-14454	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm060166w
	11626748	140134	0	None	-14	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	459	4	0	7	3.1	CN1CCN(c2ccc3nc(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)cn3n2)CC1	10.1021/jm060166w
	CHEMBL380287	140134	0	None	-14	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	459	4	0	7	3.1	CN1CCN(c2ccc3nc(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)cn3n2)CC1	10.1021/jm060166w
	44340186	9628	0	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
	CHEMBL112831	9628	0	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
	9995904	31189	4	None	-14454	5	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm0009989
	CHEMBL140099	31189	4	None	-14454	5	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm0009989
	25139180	184317	0	None	-42	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	490	10	1	2	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
	CHEMBL484357	184317	0	None	-42	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	490	10	1	2	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
	25099152	187262	0	None	-20417	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	466	9	2	5	5.1	CCCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c2ccccc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	CHEMBL492883	187262	0	None	-20417	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	466	9	2	5	5.1	CCCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c2ccccc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	25130817	187488	0	None	-5888	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	518	9	2	5	6.5	CC(C)CCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	CHEMBL494309	187488	0	None	-5888	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	518	9	2	5	6.5	CC(C)CCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	73347474	91030	0	None	-12882	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
	CHEMBL2397478	91030	0	None	-12882	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
	137655556	158515	0	None	-3801	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	2	7	3.3	O=c1ccc2c(N3CCCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
	CHEMBL4091507	158515	0	None	-3801	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	2	7	3.3	O=c1ccc2c(N3CCCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
	71733935	90954	0	None	-30902	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
	CHEMBL2396663	90954	0	None	-30902	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
	14665503	91205	0	None	-21379	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	382	7	1	4	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
	CHEMBL240106	91205	0	None	-21379	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	382	7	1	4	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
	44437896	152444	0	None	-1174	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	400	6	1	3	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)ccc1OC	10.1016/j.bmc.2007.07.017
	CHEMBL397103	152444	0	None	-1174	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	400	6	1	3	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)ccc1OC	10.1016/j.bmc.2007.07.017
	44329283	207618	0	None	-30	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@H]1CCn2c(CO)ccc2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL95230	207618	0	None	-30	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@H]1CCn2c(CO)ccc2C1	10.1016/s0960-894x(01)00564-9
	53321194	58572	0	None	-56	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
	CHEMBL1684135	58572	0	None	-56	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
	154724650	176313	1	None	-74	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4543870	176313	1	None	-74	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4595492	176313	1	None	-74	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
	154706711	176491	1	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4439535	176491	1	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4596930	176491	1	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
	10024430	207590	0	None	-41	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
	CHEMBL95098	207590	0	None	-41	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
	135398737	955	93	None	-44	92	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
	38	955	93	None	-44	92	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
	722	955	93	None	-44	92	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
	CHEMBL42	955	93	None	-44	92	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
	DB00363	955	93	None	-44	92	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
	135398737	955	93	None	-44	92	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
	38	955	93	None	-44	92	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
	722	955	93	None	-44	92	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
	CHEMBL42	955	93	None	-44	92	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
	DB00363	955	93	None	-44	92	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
	156011597	177355	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
	CHEMBL4637938	177355	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
	72699717	115164	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	5	1	4	4.9	CCCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	CHEMBL3344460	115164	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	5	1	4	4.9	CCCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	2600	3750	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	2608	3750	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	5405	3750	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	CHEMBL17157	3750	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	DB00342	3750	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	57393083	70138	0	None	-21	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	314	6	0	4	2.8	Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940415	70138	0	None	-21	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	314	6	0	4	2.8	Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	45483261	197863	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	380	3	0	6	3.4	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2ncncc21	10.1016/j.bmcl.2009.09.041
	CHEMBL572708	197863	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	380	3	0	6	3.4	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2ncncc21	10.1016/j.bmcl.2009.09.041
	11795165	9337	1	None	-3	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2sccc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
	CHEMBL111352	9337	1	None	-3	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2sccc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
	CHEMBL541842	9337	1	None	-3	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2sccc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
	45267373	13986	0	None	-11	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	295	1	2	3	3.5	CCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL1197201	13986	0	None	-11	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	295	1	2	3	3.5	CCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL562460	13986	0	None	-11	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	295	1	2	3	3.5	CCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	44278589	98422	0	None	-11	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@@H]1Cc1ccccc1-3	10.1021/jm00402a024
	CHEMBL27574	98422	0	None	-11	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@@H]1Cc1ccccc1-3	10.1021/jm00402a024
	5311191	112604	7	None	-35	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
	CHEMBL330274	112604	7	None	-35	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
	15021875	104342	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm00111a046
	CHEMBL310153	104342	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm00111a046
	15021875	104342	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm981094e
	CHEMBL310153	104342	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm981094e
	10645469	110530	0	None	-5	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
	CHEMBL325253	110530	0	None	-5	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
	CHEMBL542428	110530	0	None	-5	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
	9979654	207896	0	None	-14	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
	CHEMBL96781	207896	0	None	-14	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
	155516042	176269	0	None	-891	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4443039	176269	0	None	-891	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4595150	176269	0	None	-891	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	12442999	87481	6	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL2334890	87481	6	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	57391307	70134	0	None	-19	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	348	6	0	3	4.1	Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940411	70134	0	None	-19	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	348	6	0	3	4.1	Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
	71722301	102446	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	CHEMBL3040157	102446	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	CHEMBL3216146	102446	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	53324045	57041	0	None	-3	16	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL1644980	57041	0	None	-3	16	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
	44358192	202120	5	None	-676	2	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	345	1	2	2	2.3	CN1C[C@H](C(N)=O)C=C2c3cccc4[nH]c(Br)c(c34)C[C@H]21	10.1021/jm9800292
	CHEMBL609151	202120	5	None	-676	2	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	345	1	2	2	2.3	CN1C[C@H](C(N)=O)C=C2c3cccc4[nH]c(Br)c(c34)C[C@H]21	10.1021/jm9800292
	10862670	18470	0	None	-281	5	Rat	5.9	pKi	=	5.9	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3n2)CC1	10.1021/jm0211220
	CHEMBL126439	18470	0	None	-281	5	Rat	5.9	pKi	=	5.9	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3n2)CC1	10.1021/jm0211220
	CHEMBL127317	18470	0	None	-281	5	Rat	5.9	pKi	=	5.9	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3n2)CC1	10.1021/jm0211220
	15467373	101827	0	None	-107	4	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(99)00302-9
	CHEMBL300553	101827	0	None	-107	4	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(99)00302-9
	53946795	67703	1	None	-1122	2	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
	CHEMBL1907814	67703	1	None	-1122	2	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
	136074292	203547	0	None	-3	2	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cnccc3Nc3ccccc32)CC1	10.1021/jm00067a009
	CHEMBL66730	203547	0	None	-3	2	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cnccc3Nc3ccccc32)CC1	10.1021/jm00067a009
	44304652	200299	0	None	-28	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
	CHEMBL59749	200299	0	None	-28	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
	71062646	149519	0	None	-2238	13	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
	CHEMBL3946661	149519	0	None	-2238	13	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
	13373172	199760	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	251	0	1	2	3.0	Oc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
	CHEMBL593897	199760	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	251	0	1	2	3.0	Oc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
	17756212	86339	1	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
	CHEMBL231374	86339	1	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
	2286	3161	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	4927	3161	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	7282	3161	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	CHEMBL643	3161	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	DB01069	3161	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	11080	29054	79	None	-5	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	CHEMBL1381098	29054	79	None	-5	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	44210226	116505	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
	CHEMBL336218	116505	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
	117773821	132435	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	1	4	4.0	Cc1cc(Oc2ncc(F)cc2C)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697601	132435	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	1	4	4.0	Cc1cc(Oc2ncc(F)cc2C)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	10851717	78448	1	None	-15	5	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	CHEMBL2111782	78448	1	None	-15	5	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	154725484	176441	1	None	-630	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4439544	176441	1	None	-630	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4596514	176441	1	None	-630	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	9970201	170619	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
	CHEMBL445129	170619	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
	168295528	193007	0	None	-338	20	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5206565	193007	0	None	-338	20	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222872	193007	0	None	-338	20	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	10249506	8773	0	None	-6	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
	CHEMBL109673	8773	0	None	-6	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
	CHEMBL544091	8773	0	None	-6	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
	10851717	78448	1	None	-15	5	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	CHEMBL2111782	78448	1	None	-15	5	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	155770281	177723	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	517	4	1	2	7.6	CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
	CHEMBL4642592	177723	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	517	4	1	2	7.6	CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
	23656544	170087	0	None	-575	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	2	3	2.6	CN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
	CHEMBL444368	170087	0	None	-575	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	2	3	2.6	CN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
	5352624	67209	44	None	-3	5	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
	CHEMBL18797	67209	44	None	-3	5	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
	2662	11352	131	None	-3	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
	CHEMBL118	11352	131	None	-3	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
	16104	161893	19	None	-1	5	Rat	7.9	pKi	=	7.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00043a008
	CHEMBL415300	161893	19	None	-1	5	Rat	7.9	pKi	=	7.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00043a008
	44415544	80208	0	None	169	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Br)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213775	80208	0	None	169	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Br)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	44415628	139767	0	None	104	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccs3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL379874	139767	0	None	104	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccs3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	156017431	177753	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
	CHEMBL4643069	177753	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
	10981731	15237	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	CHEMBL121274	15237	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	11014679	114762	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	CHEMBL333955	114762	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	16351	102703	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
	CHEMBL304902	102703	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
	9841398	99491	4	None	3	4	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL28338	99491	4	None	3	4	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	44320024	107040	0	None	51	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315750	107040	0	None	51	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	86767093	129397	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
	CHEMBL3671280	129397	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
	16351	102703	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
	CHEMBL304902	102703	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
	11014679	114762	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	CHEMBL333955	114762	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	10981731	15237	0	None	-3	3	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	CHEMBL121274	15237	0	None	-3	3	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	44276412	97637	0	None	10	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL27117	97637	0	None	10	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	44276556	99674	0	None	30	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL284644	99674	0	None	30	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	45482180	197881	0	None	-17	4	Pig	6.9	pKi	=	6.9	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	544	12	1	7	4.6	COc1ccc(-n2cc(CCCC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
	CHEMBL572867	197881	0	None	-17	4	Pig	6.9	pKi	=	6.9	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	544	12	1	7	4.6	COc1ccc(-n2cc(CCCC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
	130442480	175246	0	None	-1	24	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175246	0	None	-1	24	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	53328903	66428	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	353	0	2	5	3.5	CN1CCc2c3c(cc4c2[C@H]1Cc1ccc(O)c(O)c1-4)SCCC3=O	10.1016/j.ejmech.2011.04.028
	CHEMBL1802237	66428	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	353	0	2	5	3.5	CN1CCc2c3c(cc4c2[C@H]1Cc1ccc(O)c(O)c1-4)SCCC3=O	10.1016/j.ejmech.2011.04.028
	CHEMBL1852107	66428	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	353	0	2	5	3.5	CN1CCc2c3c(cc4c2[C@H]1Cc1ccc(O)c(O)c1-4)SCCC3=O	10.1016/j.ejmech.2011.04.028
	52919	14418	48	None	-15	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL1200986	14418	48	None	-15	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	14198590	203363	1	None	-1	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00118a012
	CHEMBL65397	203363	1	None	-1	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00118a012
	10895106	32197	0	None	-27	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	CHEMBL140968	32197	0	None	-27	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	10053476	116720	0	None	-2570	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	559	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[te]1	10.1021/jm025558r
	CHEMBL337531	116720	0	None	-2570	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	559	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[te]1	10.1021/jm025558r
	44454707	97803	0	None	-28	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2007.12.026
	CHEMBL272073	97803	0	None	-28	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2007.12.026
	44393411	66063	0	None	-316	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	587	7	1	4	6.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2s1	10.1016/j.bmcl.2004.05.052
	CHEMBL183871	66063	0	None	-316	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	587	7	1	4	6.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2s1	10.1016/j.bmcl.2004.05.052
	71459760	84043	0	None	-74	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	398	5	0	3	5.3	CCCC#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
	CHEMBL2207634	84043	0	None	-74	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	398	5	0	3	5.3	CCCC#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
	25072941	156450	0	None	-331	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4067439	156450	0	None	-331	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	137640371	156790	0	None	-933	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccc2c(C=O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4071185	156790	0	None	-933	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccc2c(C=O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	118709165	113384	0	None	-66	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	916	23	0	8	12.1	O=C(CCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318837	113384	0	None	-66	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	916	23	0	8	12.1	O=C(CCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	118709167	113386	0	None	-16	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	972	27	0	8	13.6	O=C(CCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318839	113386	0	None	-16	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	972	27	0	8	13.6	O=C(CCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	118709170	113390	0	None	-53	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1057	33	0	8	16.0	O=C(CCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318842	113390	0	None	-53	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1057	33	0	8	16.0	O=C(CCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	44372296	119461	0	None	-72	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1ccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn2c1	10.1016/s0960-894x(01)00814-9
	CHEMBL345357	119461	0	None	-72	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1ccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn2c1	10.1016/s0960-894x(01)00814-9
	CHEMBL5074765	214309	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		O=C(O)c1cc(-c2ccc([C@@H]3C[C@@H]4C[C@H]3CN4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	10.1021/acs.jmedchem.1c01964
	CHEMBL5079653	214608	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		O=C(O)c1cc(-c2ccc([C@H]3C[C@H]4C[C@@H]3NC4=O)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	10.1021/acs.jmedchem.1c01964
	CHEMBL5085145	214928	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		N[C@H]1C[C@@H](CO)[C@H](c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)C1	10.1021/acs.jmedchem.1c01964
	CHEMBL5087121	215047	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		CN(C)C(=O)COC(=O)c1cc(-c2ccc([C@H]3C[C@H]4C[C@@H]3CN4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	10.1021/acs.jmedchem.1c01964
	44380774	120449	0	None	-851	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
	CHEMBL354180	120449	0	None	-851	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
	44336571	4799	0	None	-61	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
	CHEMBL104201	4799	0	None	-61	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
	15508239	6224	0	None	-5	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	336	3	0	2	4.6	C[Si](C)(C)C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
	CHEMBL108160	6224	0	None	-5	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	336	3	0	2	4.6	C[Si](C)(C)C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
	15508240	110500	0	None	-15	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	264	3	0	2	3.3	C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
	CHEMBL325104	110500	0	None	-15	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	264	3	0	2	3.3	C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
	10496727	13230	0	None	-24	3	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	331	2	0	3	4.7	COc1c(-c2ccco2)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	CHEMBL119150	13230	0	None	-24	3	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	331	2	0	3	4.7	COc1c(-c2ccco2)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	90644066	112013	0	None	-17	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	5	0	3	4.8	Clc1ccc(N2CCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289653	112013	0	None	-17	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	5	0	3	4.8	Clc1ccc(N2CCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
	53328721	66405	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	CHEMBL1851968	66405	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	CHEMBL3216523	66405	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	279	1648	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00067a009
	49381	1648	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00067a009
	CHEMBL63756	1648	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00067a009
	279	1648	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00030a011
	49381	1648	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00030a011
	CHEMBL63756	1648	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00030a011
	44210226	116505	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
	CHEMBL336218	116505	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
	14198588	171483	2	None	2	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
	CHEMBL446396	171483	2	None	2	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
	14198590	203363	1	None	1	4	Human	6.9	pKi	=	6.9	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00129a006
	CHEMBL65397	203363	1	None	1	4	Human	6.9	pKi	=	6.9	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00129a006
	44582676	189755	0	None	-10	17	Human	5.9	pKi	=	5.9	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL516088	189755	0	None	-10	17	Human	5.9	pKi	=	5.9	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	13922235	99512	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
	CHEMBL283489	99512	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
	13922235	99512	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
	CHEMBL283489	99512	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
	13922235	99512	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
	CHEMBL283489	99512	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
	10433336	78489	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	439	8	1	4	4.3	BC#N.CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL2111925	78489	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	439	8	1	4	4.3	BC#N.CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	135	2515	43	None	-46	58	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	1796	2515	43	None	-46	58	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	4184	2515	43	None	-46	58	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	CHEMBL6437	2515	43	None	-46	58	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	DB06148	2515	43	None	-46	58	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	5320227	95808	59	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	354	6	1	5	4.6	CC(C)=CC(O)C/C(C)=C/COc1c2ccoc2cc2oc(=O)ccc12	10.1016/j.bmc.2007.12.021
	CHEMBL258939	95808	59	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	354	6	1	5	4.6	CC(C)=CC(O)C/C(C)=C/COc1c2ccoc2cc2oc(=O)ccc12	10.1016/j.bmc.2007.12.021
	154706461	176324	1	None	-60	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	6.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4470439	176324	1	None	-60	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	6.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4595600	176324	1	None	-60	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	6.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
	44537925	198721	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL582945	198721	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	156010755	177117	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	351	2	1	3	4.3	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
	CHEMBL4633950	177117	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	351	2	1	3	4.3	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
	11112574	18475	0	None	-131	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	419	8	1	6	3.0	COc1ccccc1N1CCN(CCCCNC(=O)c2cnc3ccccc3n2)CC1	10.1021/jm0211220
	CHEMBL127344	18475	0	None	-131	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	419	8	1	6	3.0	COc1ccccc1N1CCN(CCCCNC(=O)c2cnc3ccccc3n2)CC1	10.1021/jm0211220
	10732337	112964	0	None	-13	3	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	291	2	0	2	4.1	C=Cc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	CHEMBL331100	112964	0	None	-13	3	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	291	2	0	2	4.1	C=Cc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	70684207	76041	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	CHEMBL2057452	76041	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	70684207	76041	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
	CHEMBL2057452	76041	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
	31101	726	40	None	-436	36	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	35	726	40	None	-436	36	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	403	726	40	None	-436	36	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	CHEMBL493	726	40	None	-436	36	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	DB01200	726	40	None	-436	36	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	44582490	190113	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	4.2	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL517349	190113	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	4.2	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
	1353	1898	93	None	-74	86	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
	3559	1898	93	None	-74	86	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
	86	1898	93	None	-74	86	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
	CHEMBL54	1898	93	None	-74	86	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
	DB00502	1898	93	None	-74	86	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
	196129	67769	17	None	-1819	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	CHEMBL1909065	67769	17	None	-1819	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	154704368	176447	1	None	-31	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4569006	176447	1	None	-31	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4596571	176447	1	None	-31	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	11408148	128694	0	None	-371	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	443	6	1	4	4.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	CHEMBL366904	128694	0	None	-371	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	443	6	1	4	4.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	154725234	176268	1	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	CHEMBL4585289	176268	1	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	CHEMBL4595149	176268	1	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	73453	29585	24	None	-208	17	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	CHEMBL1385840	29585	24	None	-208	17	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	33630	178933	99	None	-5	28	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL47050	178933	99	None	-5	28	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	2389	3306	118	None	-346	68	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	5073	3306	118	None	-346	68	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	96	3306	118	None	-346	68	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	CHEMBL85	3306	118	None	-346	68	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	DB00734	3306	118	None	-346	68	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	156014482	177188	0	None	3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	303	2	2	3	3.3	COc1cc2c(cc1O)C(c1ccccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL4635423	177188	0	None	3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	303	2	2	3	3.3	COc1cc2c(cc1O)C(c1ccccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
	2389	3306	118	None	-489	68	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
	5073	3306	118	None	-489	68	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
	96	3306	118	None	-489	68	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
	CHEMBL85	3306	118	None	-489	68	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
	DB00734	3306	118	None	-489	68	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
	21589014	144047	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	CHEMBL3903297	144047	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	10044334	207098	18	None	-64	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
	CHEMBL92145	207098	18	None	-64	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
	44415568	140118	0	None	9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C(F)(F)F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL380236	140118	0	None	9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C(F)(F)F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	155529453	171414	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranesDisplacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranes	ChEMBL	385	4	2	3	4.3	COc1ccc2[nH]cc(C3=CCN(Cc4cc(=O)[nH]c5ccccc45)CC3)c2c1	10.1016/j.ejmech.2019.07.050
	CHEMBL4463034	171414	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranesDisplacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranes	ChEMBL	385	4	2	3	4.3	COc1ccc2[nH]cc(C3=CCN(Cc4cc(=O)[nH]c5ccccc45)CC3)c2c1	10.1016/j.ejmech.2019.07.050
	11406143	66102	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	372	7	0	3	4.5	c1ccc(Cc2ccccc2OCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm049720x
	CHEMBL184073	66102	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	372	7	0	3	4.5	c1ccc(Cc2ccccc2OCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm049720x
	10895039	18488	0	None	-3019	8	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
	CHEMBL127400	18488	0	None	-3019	8	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
	CHEMBL129022	18488	0	None	-3019	8	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
	44593524	184032	0	None	-12	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.11.025
	CHEMBL482276	184032	0	None	-12	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.11.025
	10740666	26091	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	416	6	1	3	4.5	CN(C)CCCCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL135616	26091	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	416	6	1	3	4.5	CN(C)CCCCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL4576555	213994	5	None	-1	19	Human	5.8	pKi	=	5.8	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
	CHEMBL4576555	213994	5	None	-1	19	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a DRD1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL5212743
	117773324	132405	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2cc(C3CC3)ccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697572	132405	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2cc(C3CC3)ccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	1218	3589	30	None	-11	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	938	3589	30	None	-11	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	CHEMBL353335	3589	30	None	-11	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	44415611	166235	0	None	54	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	435	2	1	6	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccco3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL426868	166235	0	None	54	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	435	2	1	6	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccco3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	11567963	155031	0	None	40	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	419	3	1	5	3.9	COc1cc2c(cc1OC)-c1c(OC)c(O)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL401689	155031	0	None	40	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	419	3	1	5	3.9	COc1cc2c(cc1OC)-c1c(OC)c(O)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	10220	138735	16	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)C1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
	CHEMBL3780481	138735	16	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)C1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
	86763997	132447	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697613	132447	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	9884087	14605	0	None	-5	3	Rat	7.8	pKi	=	7.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	CHEMBL120512	14605	0	None	-5	3	Rat	7.8	pKi	=	7.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	86767098	129404	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
	CHEMBL3671287	129404	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
	130442572	171884	0	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171884	0	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	44415395	138136	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	423	2	1	5	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL376928	138136	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	423	2	1	5	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	53328901	66451	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	371	4	3	5	3.4	CN1CCc2cc(SCCC(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	CHEMBL1802236	66451	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	371	4	3	5	3.4	CN1CCc2cc(SCCC(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	CHEMBL1852245	66451	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	371	4	3	5	3.4	CN1CCc2cc(SCCC(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	90644226	111752	0	None	-72	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	490	9	0	7	4.8	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287395	111752	0	None	-72	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	490	9	0	7	4.8	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	118709179	113399	0	None	-61	4	Pig	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1198	35	0	18	9.5	O=C(CCc1cn(CCOCCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318851	113399	0	None	-61	4	Pig	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1198	35	0	18	9.5	O=C(CCc1cn(CCOCCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	681	1453	72	None	-97	39	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
	940	1453	72	None	-97	39	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
	947	1453	72	None	-97	39	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
	CHEMBL59	1453	72	None	-97	39	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
	DB00988	1453	72	None	-97	39	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
	10546131	100381	0	None	20	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL290149	100381	0	None	20	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
	10476504	33457	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	CHEMBL142020	33457	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	44361021	118760	0	None	-537	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1	10.1021/jm025558r
	CHEMBL342060	118760	0	None	-537	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1	10.1021/jm025558r
	10884046	165345	0	None	-107	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
	CHEMBL423735	165345	0	None	-107	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
	44436602	145188	0	None	-245	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2007.08.038
	CHEMBL391256	145188	0	None	-245	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2007.08.038
	44436598	149271	0	None	-3388	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
	CHEMBL394473	149271	0	None	-3388	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
	53361302	63820	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
	CHEMBL1803049	63820	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
	11696910	77718	0	None	-1174	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	395	3	0	5	4.0	Clc1ccc2nc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cn2n1	10.1021/jm060166w
	CHEMBL209034	77718	0	None	-1174	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	395	3	0	5	4.0	Clc1ccc2nc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cn2n1	10.1021/jm060166w
	53361302	63820	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
	CHEMBL1803049	63820	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
	45268292	196664	0	None	-446	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	460	4	1	6	3.5	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
	CHEMBL564688	196664	0	None	-446	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	460	4	1	6	3.5	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
	71583848	87702	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
	CHEMBL2336892	87702	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
	137636498	156172	0	None	-660	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	446	7	2	6	3.8	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	CHEMBL4064186	156172	0	None	-660	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	446	7	2	6	3.8	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	118709171	113391	0	None	-5	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1085	35	0	8	16.8	O=C(CCCCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318843	113391	0	None	-5	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1085	35	0	8	16.8	O=C(CCCCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	122189389	123218	0	None	-346	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	497	8	0	8	4.2	O=Cc1cnn2ccc(-n3cc(CCCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
	CHEMBL3613875	123218	0	None	-346	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	497	8	0	8	4.2	O=Cc1cnn2ccc(-n3cc(CCCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
	13678304	101686	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	229	3	3	3	2.3	NCCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
	CHEMBL299511	101686	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	229	3	3	3	2.3	NCCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
	44371996	53593	0	None	-8	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	500	6	0	6	4.6	Clc1ccc(N2CCN(Cc3cnn4c(N5CCN(Cc6ccccc6)CC5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
	CHEMBL160266	53593	0	None	-8	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	500	6	0	6	4.6	Clc1ccc(N2CCN(Cc3cnn4c(N5CCN(Cc6ccccc6)CC5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
	44371980	53905	0	None	-57	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	514	6	0	6	4.9	Cc1nn2c(N3CCN(Cc4ccccc4)CC3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
	CHEMBL160536	53905	0	None	-57	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	514	6	0	6	4.9	Cc1nn2c(N3CCN(Cc4ccccc4)CC3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
	44400674	125163	0	None	-3019	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL364516	125163	0	None	-3019	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	44264623	204990	0	None	-1174	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnc4ccccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	CHEMBL7686	204990	0	None	-1174	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnc4ccccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	11659604	138549	0	None	-30	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4ccncc4n3)CC2)cc1	10.1021/jm060166w
	CHEMBL377542	138549	0	None	-30	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4ccncc4n3)CC2)cc1	10.1021/jm060166w
	44336552	111313	1	None	-53	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
	CHEMBL326864	111313	1	None	-53	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
	9977478	204920	2	None	-234422	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	386	6	2	5	2.4	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
	CHEMBL76402	204920	2	None	-234422	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	386	6	2	5	2.4	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
	56926586	68980	0	None	-2089	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	344	3	1	5	2.6	Oc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
	CHEMBL1923415	68980	0	None	-2089	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	344	3	1	5	2.6	Oc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
	44381217	59116	0	None	-9	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
	CHEMBL169889	59116	0	None	-9	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
	44371997	49900	0	None	-10000	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	364	3	0	4	3.6	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)c(C)nn12	10.1016/s0960-894x(01)00814-9
	CHEMBL156851	49900	0	None	-10000	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	364	3	0	4	3.6	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)c(C)nn12	10.1016/s0960-894x(01)00814-9
	154704941	176603	1	None	-47	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	470	11	0	6	5.8	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4578364	176603	1	None	-47	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	470	11	0	6	5.8	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4597877	176603	1	None	-47	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	470	11	0	6	5.8	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	167715	2856	14	None	-194	5	Human	5.8	pKi	=	5.8	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9800292
	969	2856	14	None	-194	5	Human	5.8	pKi	=	5.8	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9800292
	CHEMBL225230	2856	14	None	-194	5	Human	5.8	pKi	=	5.8	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9800292
	46231834	200889	0	None	-117	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	488	3	1	5	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCN(c5ccccn5)CC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL601635	200889	0	None	-117	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	488	3	1	5	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCN(c5ccccn5)CC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	10684714	100282	0	None	13	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115372	100282	0	None	13	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL289283	100282	0	None	13	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL5289958	194463	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constantDisplacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constant	ChEMBL	429	4	1	2	5.6	Fc1ccc(CN2CCCC3(CCN(Cc4cc5ccc(Cl)cc5[nH]4)C3)C2)cc1F	10.1016/j.ejmech.2022.114840
	72301	186094	76	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
	CHEMBL487182	186094	76	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
	44415367	79919	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	411	3	1	5	3.9	CCCC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	CHEMBL212597	79919	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	411	3	1	5	3.9	CCCC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	44401105	69547	0	None	-17	9	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL193435	69547	0	None	-17	9	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
	44320327	163400	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL419680	163400	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10623632	48264	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	453	4	1	3	5.1	CCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
	CHEMBL155351	48264	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	453	4	1	3	5.1	CCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
	44326982	8627	0	None	-7	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm981094e
	CHEMBL109548	8627	0	None	-7	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm981094e
	CHEMBL545727	8627	0	None	-7	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm981094e
	9886130	206407	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
	CHEMBL87943	206407	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
	9886130	206407	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm00042a009
	CHEMBL87943	206407	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm00042a009
	131990	43915	11	None	-6	2	Rat	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cnccc3Sc3ccccc32)CC1	10.1021/jm00030a011
	CHEMBL151263	43915	11	None	-6	2	Rat	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cnccc3Sc3ccccc32)CC1	10.1021/jm00030a011
	156018868	177903	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	378	5	1	4	4.0	C=CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4645375	177903	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	378	5	1	4	4.0	C=CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	12050195	203261	0	None	-21	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	6	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL64696	203261	0	None	-21	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	6	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
	11057	176125	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	3468	176125	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL459265	176125	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL64894	176125	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	117772791	132396	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	323	3	1	5	2.5	Cc1cc(Oc2ccccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697563	132396	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	323	3	1	5	2.5	Cc1cc(Oc2ccccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	44415625	80066	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL213145	80066	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	11732785	163696	0	None	-1819	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	432	7	0	5	3.7	COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc43)C2=O)CC1	10.1021/jm0211220
	CHEMBL420510	163696	0	None	-1819	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	432	7	0	5	3.7	COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc43)C2=O)CC1	10.1021/jm0211220
	44278409	100306	0	None	-616	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	418	6	0	4	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
	CHEMBL28946	100306	0	None	-616	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	418	6	0	4	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
	44415543	79921	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212608	79921	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	44415543	79921	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL212608	79921	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	10052433	165333	0	None	-501	4	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	521	10	1	6	4.1	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
	CHEMBL423671	165333	0	None	-501	4	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	521	10	1	6	4.1	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
	16090821	81804	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
	CHEMBL216439	81804	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
	10851717	78448	1	None	-15	5	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	CHEMBL2111782	78448	1	None	-15	5	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	1353	1898	93	None	-74	86	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
	3559	1898	93	None	-74	86	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
	86	1898	93	None	-74	86	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
	CHEMBL54	1898	93	None	-74	86	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
	DB00502	1898	93	None	-74	86	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
	9817779	114406	0	None	-2	3	Rat	6.8	pKi	=	6.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
	CHEMBL333246	114406	0	None	-2	3	Rat	6.8	pKi	=	6.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
	1830	2572	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
	207	2572	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
	23897	2572	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
	CHEMBL460	2572	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
	DB01618	2572	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
	10851717	78448	1	None	-15	5	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	CHEMBL2111782	78448	1	None	-15	5	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	44323894	168076	0	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	304	1	0	2	3.9	CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
	CHEMBL432762	168076	0	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	304	1	0	2	3.9	CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
	15115524	108983	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	735	3	5	8	7.8	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N/C(S)=N/c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)cc2)C1	10.1021/jm00115a012
	CHEMBL321223	108983	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	735	3	5	8	7.8	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N/C(S)=N/c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)cc2)C1	10.1021/jm00115a012
	6761	67770	19	None	-5	18	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	CHEMBL1909072	67770	19	None	-5	18	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	44415701	80057	0	None	16	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	569	5	1	8	5.1	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
	CHEMBL213110	80057	0	None	16	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	569	5	1	8	5.1	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
	44415584	138669	0	None	50	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Br)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL377877	138669	0	None	50	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Br)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	44415601	141436	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	481	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL384269	141436	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	481	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	156018764	177771	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	2	1	3	3.8	COc1cc2c(cc1O)C(c1ccccc1Br)CN(C)CC2	10.1016/j.bmcl.2020.127305
	CHEMBL4643426	177771	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	2	1	3	3.8	COc1cc2c(cc1O)C(c1ccccc1Br)CN(C)CC2	10.1016/j.bmcl.2020.127305
	9844271	130656	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL368324	130656	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	9884087	14605	0	None	-5	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	CHEMBL120512	14605	0	None	-5	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	9844271	130656	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL368324	130656	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	9844271	130656	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	CHEMBL368324	130656	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	11716449	141190	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	CHEMBL382850	141190	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	72699815	115170	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	349	3	1	4	3.9	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344467	115170	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	349	3	1	4	3.9	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	117773776	132433	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	3	1	5	3.9	Cc1cc(Sc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697599	132433	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	3	1	5	3.9	Cc1cc(Sc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	9817779	114406	0	None	-2	3	Rat	6.8	pKi	=	6.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
	CHEMBL333246	114406	0	None	-2	3	Rat	6.8	pKi	=	6.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
	45269168	195907	0	None	-10	4	Bovine	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	410	4	1	6	2.3	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(F)cc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
	CHEMBL559399	195907	0	None	-10	4	Bovine	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	410	4	1	6	2.3	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(F)cc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
	122189390	123219	0	None	-16	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	6	0	8	3.4	O=Cc1cnn2ccc(-n3cc(CCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
	CHEMBL3613876	123219	0	None	-16	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	6	0	8	3.4	O=Cc1cnn2ccc(-n3cc(CCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
	10973768	107533	0	None	-4073	10	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	563	6	1	8	4.4	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
	CHEMBL318901	107533	0	None	-4073	10	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	563	6	1	8	4.4	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
	681	1453	72	None	-23	39	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	940	1453	72	None	-23	39	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	947	1453	72	None	-23	39	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	CHEMBL59	1453	72	None	-23	39	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	DB00988	1453	72	None	-23	39	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	10403608	78131	5	None	-1584	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	CHEMBL210405	78131	5	None	-1584	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	44412468	165906	0	None	-616	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cnn(-c4ccccn4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	CHEMBL425057	165906	0	None	-616	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cnn(-c4ccccn4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	53317282	58568	0	None	-173	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
	CHEMBL1684131	58568	0	None	-173	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
	24949534	189494	0	None	-2041	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
	CHEMBL514074	189494	0	None	-2041	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
	10403608	78131	5	None	-1584	6	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
	CHEMBL210405	78131	5	None	-1584	6	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
	145979897	166582	0	None	-158	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	480	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(I)cc1)CC2	10.1021/acsmedchemlett.8b00229
	CHEMBL4280542	166582	0	None	-158	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	480	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(I)cc1)CC2	10.1021/acsmedchemlett.8b00229
	57400556	69281	0	None	-2398	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	3.1	CCOCCOc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
	CHEMBL1928134	69281	0	None	-2398	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	3.1	CCOCCOc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
	10476504	33457	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1016/j.bmc.2017.04.036
	CHEMBL142020	33457	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1016/j.bmc.2017.04.036
	10824155	57210	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	243	5	0	1	3.6	C#CC(C#C)=C1CCC(N(CCC)CCC)CC1	10.1021/jm991098z
	CHEMBL165022	57210	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	243	5	0	1	3.6	C#CC(C#C)=C1CCC(N(CCC)CCC)CC1	10.1021/jm991098z
	44436601	91914	0	None	-1584	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(C#Cc3ccccc3)cc2)CC1	10.1016/j.bmc.2007.08.038
	CHEMBL241424	91914	0	None	-1584	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(C#Cc3ccccc3)cc2)CC1	10.1016/j.bmc.2007.08.038
	15508238	4763	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	340	3	0	2	4.7	C(#Cc1cccn1C1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/s0960-894x(99)00540-5
	CHEMBL104092	4763	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	340	3	0	2	4.7	C(#Cc1cccn1C1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/s0960-894x(99)00540-5
	72544787	93101	0	None	-501	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	587	12	3	12	1.2	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4F)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443008	93101	0	None	-501	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	587	12	3	12	1.2	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4F)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	57400562	69289	0	None	-16	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(N2CCN(CCCCNC(=O)c3ccccc3)CC2)c(OC)c1	10.1016/j.bmc.2011.10.063
	CHEMBL1928247	69289	0	None	-16	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(N2CCN(CCCCNC(=O)c3ccccc3)CC2)c(OC)c1	10.1016/j.bmc.2011.10.063
	71449034	78394	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL2111526	78394	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	44319361	205697	0	None	-7	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
	CHEMBL82527	205697	0	None	-7	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
	10200496	83564	0	None	-295	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	391	6	1	3	3.6	O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm1013693
	CHEMBL2204343	83564	0	None	-295	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	391	6	1	3	3.6	O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm1013693
	11653679	181167	1	None	-24	11	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
	CHEMBL476108	181167	1	None	-24	11	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
	9872676	78166	0	None	-4073	17	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
	CHEMBL210514	78166	0	None	-4073	17	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
	11419055	129278	0	None	-24	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	431	4	1	5	3.0	O=C1NCCN1CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	CHEMBL367087	129278	0	None	-24	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	431	4	1	5	3.0	O=C1NCCN1CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	10335576	120905	5	None	2	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3ccccc3Sc3ncccc32)CC1	10.1021/jm00030a011
	CHEMBL356076	120905	5	None	2	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3ccccc3Sc3ncccc32)CC1	10.1021/jm00030a011
	44278267	100236	0	None	-53	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	368	6	0	2	4.6	O=C1c2ccccc2CN1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
	CHEMBL28884	100236	0	None	-53	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	368	6	0	2	4.6	O=C1c2ccccc2CN1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
	16090821	81804	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
	CHEMBL216439	81804	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
	46889212	7437	0	None	-263	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccncc1	10.1016/j.bmcl.2010.02.106
	CHEMBL1086958	7437	0	None	-263	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccncc1	10.1016/j.bmcl.2010.02.106
	13678338	100694	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.8	Oc1ccc(-c2c(O)c(O)c(Cl)c3c2CCNCC3)cc1	10.1021/jm00160a018
	CHEMBL292611	100694	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.8	Oc1ccc(-c2c(O)c(O)c(Cl)c3c2CCNCC3)cc1	10.1021/jm00160a018
	14198580	197939	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	301	3	0	2	4.1	COc1cc2c(cc1Cl)CCN(C)C2Cc1ccccc1	10.1016/j.bmc.2009.05.079
	CHEMBL573412	197939	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	301	3	0	2	4.1	COc1cc2c(cc1Cl)CCN(C)C2Cc1ccccc1	10.1016/j.bmc.2009.05.079
	154725766	176621	1	None	-1380	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4527244	176621	1	None	-1380	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4598000	176621	1	None	-1380	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	10546132	161231	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL41196	161231	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	44299852	198112	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	245	3	4	4	2.0	NCCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
	CHEMBL57470	198112	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	245	3	4	4	2.0	NCCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
	11346967	125401	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	3	3.4	O=C(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
	CHEMBL364586	125401	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	3	3.4	O=C(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
	11812345	16881	0	None	-213	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1cc2ccccc2o1	10.1021/jm0211220
	CHEMBL125193	16881	0	None	-213	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1cc2ccccc2o1	10.1021/jm0211220
	15711860	13826	0	None	1	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
	CHEMBL1195937	13826	0	None	1	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
	CHEMBL555619	13826	0	None	1	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
	15069443	100944	0	None	3	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@H]21	10.1021/jm00128a038
	CHEMBL294215	100944	0	None	3	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@H]21	10.1021/jm00128a038
	154726922	176517	1	None	-19	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4442936	176517	1	None	-19	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4597157	176517	1	None	-19	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	15696481	79637	0	None	21	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL2115213	79637	0	None	21	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	11404156	66252	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	311	6	0	3	3.4	CC1CN(CCOc2ccccc2Cc2ccccc2)CCO1	10.1021/jm049720x
	CHEMBL184724	66252	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	311	6	0	3	3.4	CC1CN(CCOc2ccccc2Cc2ccccc2)CCO1	10.1021/jm049720x
	71722295	102440	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397381	102440	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040115	102440	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	145990190	166829	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4285528	166829	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	127035062	136426	0	None	-58	19	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	136426	0	None	-58	19	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	135398737	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
	38	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
	722	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
	CHEMBL42	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
	DB00363	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
	135398737	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	38	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	722	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	CHEMBL42	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	DB00363	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	24800688	155694	0	None	-15	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	309	3	1	3	3.9	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
	CHEMBL405345	155694	0	None	-15	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	309	3	1	3	3.9	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
	10498848	120026	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)cc2c1C(Cc1ccccc1O)N(C)CC2	10.1021/jm991034o
	CHEMBL350471	120026	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)cc2c1C(Cc1ccccc1O)N(C)CC2	10.1021/jm991034o
	72708061	92170	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
	CHEMBL2425372	92170	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
	44582461	181893	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	350	5	0	4	2.3	O=C1c2ccccc2CCN1CCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL477961	181893	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	350	5	0	4	2.3	O=C1c2ccccc2CCN1CCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
	70692655	76045	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
	CHEMBL2057456	76045	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
	71109804	87477	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	nan
	CHEMBL2334882	87477	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	nan
	70692655	76045	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL2057456	76045	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	117772871	132455	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697621	132455	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	74223831	129427	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	2	6	2.1	Cc1c(-c2ccc(Oc3nccc4n[nH]cc34)cc2)n(C)c(=O)[nH]c1=O	nan
	CHEMBL3671308	129427	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	2	6	2.1	Cc1c(-c2ccc(Oc3nccc4n[nH]cc34)cc2)n(C)c(=O)[nH]c1=O	nan
	15115518	8905	0	None	-380	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL109787	8905	0	None	-380	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
	135398737	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
	38	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
	722	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
	CHEMBL42	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
	DB00363	955	93	None	-83	92	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
	44447996	155479	0	None	-44	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
	CHEMBL404137	155479	0	None	-44	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
	145967572	164909	0	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	275	8	1	2	4.5	CCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4224763	164909	0	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	275	8	1	2	4.5	CCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	122167	12209	13	None	-56	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards Dopamine receptor D1In vitro binding affinity towards Dopamine receptor D1	ChEMBL	263	5	2	3	3.1	CCCN(CCC)C1CCc2c(ccc(O)c2O)C1	10.1021/jm0307786
	CHEMBL11845	12209	13	None	-56	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards Dopamine receptor D1In vitro binding affinity towards Dopamine receptor D1	ChEMBL	263	5	2	3	3.1	CCCN(CCC)C1CCc2c(ccc(O)c2O)C1	10.1021/jm0307786
	44340302	9720	0	None	-3	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL113471	9720	0	None	-3	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	25139329	187079	0	None	-11	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	514	10	0	4	7.6	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
	CHEMBL491466	187079	0	None	-11	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	514	10	0	4	7.6	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
	71583848	87702	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
	CHEMBL2336892	87702	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
	137636460	156096	0	None	-120	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	7	1	6	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4063282	156096	0	None	-120	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	7	1	6	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
	122189387	123216	0	None	-45	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	417	7	0	8	2.7	COc1ccccc1N1CCN(CCCc2cn(-c3ccn4nccc4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
	CHEMBL3613873	123216	0	None	-45	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	417	7	0	8	2.7	COc1ccccc1N1CCN(CCCc2cn(-c3ccn4nccc4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
	44400594	133550	0	None	-85	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL371165	133550	0	None	-85	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	240	941	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
	2769	941	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
	44279790	941	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
	660	941	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
	CHEMBL1729	941	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
	CHEMBL560739	941	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
	DB00604	941	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
	4420454	56229	6	None	-41	5	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
	CHEMBL162762	56229	6	None	-41	5	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
	10454684	204782	0	None	-5623	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	418	3	0	4	3.3	Ic1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	CHEMBL7508	204782	0	None	-5623	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	418	3	0	4	3.3	Ic1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	44340186	9628	0	None	-45	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
	CHEMBL112831	9628	0	None	-45	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
	137640152	156729	0	None	-10715	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	631	15	3	10	4.0	CCCCn1cc(CCCOc2ccc(C(=O)NCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
	CHEMBL4070604	156729	0	None	-10715	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	631	15	3	10	4.0	CCCCn1cc(CCCOc2ccc(C(=O)NCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
	44437897	153029	0	None	-776	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	352	6	1	3	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)ccc1OC	10.1016/j.bmc.2007.07.017
	CHEMBL397592	153029	0	None	-776	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	352	6	1	3	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)ccc1OC	10.1016/j.bmc.2007.07.017
	90644059	112003	0	None	-22	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
	CHEMBL3289643	112003	0	None	-22	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
	25132869	103268	0	None	-269	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	400	3	2	2	5.5	O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
	CHEMBL3084503	103268	0	None	-269	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	400	3	2	2	5.5	O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
	154705296	176370	1	None	-39	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	6.9	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4444691	176370	1	None	-39	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	6.9	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4595970	176370	1	None	-39	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	6.9	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
	154726793	176209	1	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4590966	176209	1	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4594692	176209	1	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	45481839	198071	0	None	-22	2	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	4	1	2	3.7	CCCCC1NCCc2cc(Cl)c(OC)cc21	10.1016/j.bmc.2009.05.079
	CHEMBL574418	198071	0	None	-22	2	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	4	1	2	3.7	CCCCC1NCCc2cc(Cl)c(OC)cc21	10.1016/j.bmc.2009.05.079
	46227284	199692	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.5	COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2	10.1016/j.bmc.2009.08.028
	CHEMBL593394	199692	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.5	COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2	10.1016/j.bmc.2009.08.028
	11351639	60494	0	None	-93	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	459	6	1	4	5.3	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
	CHEMBL175734	60494	0	None	-93	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	459	6	1	4	5.3	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
	44299993	101895	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
	CHEMBL301003	101895	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
	72708058	92166	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425368	92166	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	25256817	181402	0	None	-169	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	445	6	0	3	5.0	O=C1c2ccccc2CCCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL476394	181402	0	None	-169	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	445	6	0	3	5.0	O=C1c2ccccc2CCCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
	44582489	189776	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	3.9	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL516270	189776	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	3.9	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
	14198596	101616	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL299056	101616	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
	145969667	164941	0	None	-30	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4225278	164941	0	None	-30	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	14198596	101616	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00118a012
	CHEMBL299056	101616	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00118a012
	13678327	202031	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	329	8	3	4	4.1	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
	CHEMBL60861	202031	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	329	8	3	4	4.1	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
	11151583	129437	0	None	-15	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	327	2	1	5	2.6	CN1CCN(C2=Cn3c(CO)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
	CHEMBL367180	129437	0	None	-15	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	327	2	1	5	2.6	CN1CCN(C2=Cn3c(CO)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
	44415738	79865	0	None	22	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	1	1	4	6.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(C(=O)Nc3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212384	79865	0	None	22	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	1	1	4	6.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(C(=O)Nc3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	135995891	202937	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	413	4	1	5	4.1	Oc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL62996	202937	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	413	4	1	5	4.1	Oc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
	154726046	176287	1	None	-446	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4442408	176287	1	None	-446	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4595266	176287	1	None	-446	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	44582678	181550	0	None	-12	10	Human	5.8	pKi	=	5.8	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL476839	181550	0	None	-12	10	Human	5.8	pKi	=	5.8	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	15696482	79530	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL2114209	79530	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	14198596	101616	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL299056	101616	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
	14198600	101864	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	CHEMBL300778	101864	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	14198601	100874	1	None	1	4	Human	6.8	pKi	=	6.8	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
	CHEMBL293828	100874	1	None	1	4	Human	6.8	pKi	=	6.8	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
	44582115	181651	0	None	-154	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	6	0	3	4.6	O=C1c2ccccc2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL477646	181651	0	None	-154	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	6	0	3	4.6	O=C1c2ccccc2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
	180	400	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	200	400	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	2160	400	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	CHEMBL629	400	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	DB00321	400	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	130907	194660	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	CHEMBL53294	194660	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	1704	3496	85	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
	4331799	3496	85	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
	CHEMBL1334465	3496	85	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
	23656545	146745	0	None	-83	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	3	3.5	COc1cc2c3c(c1)-c1c(ccc(C)c1O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2007.05.057
	CHEMBL392447	146745	0	None	-83	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	3	3.5	COc1cc2c3c(c1)-c1c(ccc(C)c1O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2007.05.057
	14198600	101864	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	CHEMBL300778	101864	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	1212	1649	50	None	-51	66	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
	204	1649	50	None	-51	66	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
	3372	1649	50	None	-51	66	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
	CHEMBL726	1649	50	None	-51	66	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
	DB00623	1649	50	None	-51	66	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
	14198601	100874	1	None	-1	4	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
	CHEMBL293828	100874	1	None	-1	4	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
	13678309	194903	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	255	1	3	3	2.5	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2	10.1021/jm00160a018
	CHEMBL54168	194903	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	255	1	3	3	2.5	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2	10.1021/jm00160a018
	3036864	202731	19	None	-26	28	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1256645	202731	19	None	-26	28	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1814790	202731	19	None	-26	28	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL62	202731	19	None	-26	28	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	10084583	104751	4	None	-33	6	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	271	5	0	3	3.3	CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
	CHEMBL310867	104751	4	None	-33	6	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	271	5	0	3	3.3	CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
	5281878	1647	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
	5281881	1647	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
	948	1647	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
	968	1647	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
	CHEMBL42055	1647	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
	CHEMBL54661	1647	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
	DB00875	1647	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
	44578927	189638	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	335	4	0	3	4.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)CC)c1-3	10.1016/j.bmc.2008.08.056
	CHEMBL515187	189638	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	335	4	0	3	4.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)CC)c1-3	10.1016/j.bmc.2008.08.056
	11976	917	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
	667467	917	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
	CHEMBL908	917	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
	DB01239	917	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
	10684714	100282	0	None	13	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115372	100282	0	None	13	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL289283	100282	0	None	13	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	9796958	146553	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115374	146553	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL39230	146553	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL544814	146553	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	10684715	160616	0	None	11	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL41132	160616	0	None	11	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	11089340	12856	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	2	0	4	4.0	CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL118889	12856	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	2	0	4	4.0	CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	17756101	98556	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1021/jm070388+
	CHEMBL276778	98556	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1021/jm070388+
	86764103	132411	13	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697578	132411	13	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	10457445	103166	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	470	14	4	6	5.0	CCCN(CCCCCCN1CCC[C@@H]1Cc1ccc(O)c(O)c1)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
	CHEMBL308295	103166	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	470	14	4	6	5.0	CCCN(CCCCCCN1CCC[C@@H]1Cc1ccc(O)c(O)c1)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
	10656804	116533	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL336366	116533	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
	1621	2413	17	None	-112	45	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	17	2413	17	None	-112	45	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	5761	2413	17	None	-112	45	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	CHEMBL263881	2413	17	None	-112	45	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	DB04829	2413	17	None	-112	45	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	44276414	97600	0	None	12	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL27101	97600	0	None	12	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	45482169	197815	0	None	-6	4	Pig	6.8	pKi	=	6.8	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	559	12	1	8	4.5	O=C(CCCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2009.06.041
	CHEMBL572379	197815	0	None	-6	4	Pig	6.8	pKi	=	6.8	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	559	12	1	8	4.5	O=C(CCCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2009.06.041
	135398737	955	93	None	-44	92	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	38	955	93	None	-44	92	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	722	955	93	None	-44	92	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	CHEMBL42	955	93	None	-44	92	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	DB00363	955	93	None	-44	92	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	44209472	70143	2	None	-97	11	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940420	70143	2	None	-97	11	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	90644228	111759	0	None	-29	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287402	111759	0	None	-29	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	11092112	207605	0	None	-3162	9	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	485	6	0	6	4.9	O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
	CHEMBL95175	207605	0	None	-3162	9	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	485	6	0	6	4.9	O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
	44403232	71047	0	None	-112	5	Pig	5.8	pKi	=	5.8	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	459	8	1	4	4.0	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
	CHEMBL195247	71047	0	None	-112	5	Pig	5.8	pKi	=	5.8	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	459	8	1	4	4.0	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
	44436610	91920	0	None	-234	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
	CHEMBL241436	91920	0	None	-234	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
	130907	194660	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	CHEMBL53294	194660	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	52937680	61143	0	None	-3235	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	466	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1Cc2cccn3ncc(c23)C1	10.1021/jm101639t
	CHEMBL1765632	61143	0	None	-3235	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	466	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1Cc2cccn3ncc(c23)C1	10.1021/jm101639t
	137659990	159206	0	None	-3019	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccn2ncc(/C=N\O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4098859	159206	0	None	-3019	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccn2ncc(/C=N\O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	57393627	69278	0	None	-199	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1101	42	2	17	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928131	69278	0	None	-199	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1101	42	2	17	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	11077918	206571	0	None	-13	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccc4ccnn34)CC2)cc1	10.1021/jm015522j
	CHEMBL88937	206571	0	None	-13	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccc4ccnn34)CC2)cc1	10.1021/jm015522j
	46869265	16225	0	None	-4	7	Human	4.8	pKi	=	4.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
	CHEMBL1224527	16225	0	None	-4	7	Human	4.8	pKi	=	4.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
	73353534	91029	0	None	-4168	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
	CHEMBL2397477	91029	0	None	-4168	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
	71733932	91023	0	None	-24547	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
	CHEMBL2397389	91023	0	None	-24547	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
	23642427	91770	0	None	-38904	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	430	7	1	4	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
	CHEMBL241169	91770	0	None	-38904	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	430	7	1	4	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
	24824061	97869	0	None	-25	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
	CHEMBL272396	97869	0	None	-25	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
	10021692	146357	19	None	-23442	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	364	10	1	4	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
	CHEMBL392158	146357	19	None	-23442	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	364	10	1	4	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
	132060743	162212	0	None	-7	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
	CHEMBL4163428	162212	0	None	-7	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
	145969667	164941	0	None	-30	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4225278	164941	0	None	-30	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	228	444	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
	33	444	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
	6005	444	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
	CHEMBL53	444	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
	DB00714	444	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
	11559090	155537	0	None	-60	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	335	1	2	3	3.8	CC1(c2cccc(O)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
	CHEMBL404352	155537	0	None	-60	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	335	1	2	3	3.8	CC1(c2cccc(O)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
	44567689	183785	0	None	-7	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	309	3	1	3	3.9	CCCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
	CHEMBL480525	183785	0	None	-7	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	309	3	1	3	3.9	CCCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
	145979855	166504	0	None	-83	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	405	7	2	5	3.5	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccnc3ccccc13)CC2	10.1021/acsmedchemlett.8b00229
	CHEMBL4279136	166504	0	None	-83	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	405	7	2	5	3.5	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccnc3ccccc13)CC2	10.1021/acsmedchemlett.8b00229
	72708058	92166	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425368	92166	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	70690497	76034	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
	CHEMBL2057438	76034	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
	70690497	76034	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	CHEMBL2057438	76034	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	681	1453	72	None	-154	39	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
	940	1453	72	None	-154	39	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
	947	1453	72	None	-154	39	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
	CHEMBL59	1453	72	None	-154	39	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
	DB00988	1453	72	None	-154	39	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
	13903144	100058	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	285	1	0	1	4.2	Fc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(F)ccc32)cc1	10.1021/jm00391a028
	CHEMBL1743798	100058	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	285	1	0	1	4.2	Fc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(F)ccc32)cc1	10.1021/jm00391a028
	CHEMBL287332	100058	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	285	1	0	1	4.2	Fc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(F)ccc32)cc1	10.1021/jm00391a028
	46227317	200140	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.4	COc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
	CHEMBL596448	200140	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.4	COc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
	45379377	7425	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21	10.1021/jm901291r
	CHEMBL1086790	7425	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21	10.1021/jm901291r
	10107367	102407	1	None	-7	4	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL303993	102407	1	None	-7	4	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	11777127	25778	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	CHEMBL135318	25778	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	117773975	132408	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	367	4	1	6	2.9	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1C	nan
	CHEMBL3697575	132408	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	367	4	1	6	2.9	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1C	nan
	4011	82379	49	None	-64	24	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	CHEMBL21731	82379	49	None	-64	24	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	71722293	102448	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	CHEMBL2397380	102448	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	CHEMBL3040164	102448	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	135398737	955	93	None	-44	92	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
	38	955	93	None	-44	92	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
	722	955	93	None	-44	92	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
	CHEMBL42	955	93	None	-44	92	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
	DB00363	955	93	None	-44	92	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
	60165416	75267	0	None	-478	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL2037431	75267	0	None	-478	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
	44439944	151845	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2c(c1)CCN(C)CCc1c([nH]c3ccccc13)C2	10.1016/j.bmcl.2006.11.093
	CHEMBL396561	151845	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2c(c1)CCN(C)CCc1c([nH]c3ccccc13)C2	10.1016/j.bmcl.2006.11.093
	49782600	17421	0	None	-4	5	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	1	3	4.4	Cc1ccc(C)c(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
	CHEMBL1257689	17421	0	None	-4	5	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	1	3	4.4	Cc1ccc(C)c(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
	127031397	138705	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	397	7	1	5	4.6	CCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
	CHEMBL3780140	138705	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	397	7	1	5	4.6	CCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
	44401106	124301	0	None	-29	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL363581	124301	0	None	-29	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	9796255	129022	0	None	-17	8	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm0309811
	CHEMBL367045	129022	0	None	-17	8	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm0309811
	9796255	129022	0	None	-17	8	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm049629t
	CHEMBL367045	129022	0	None	-17	8	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm049629t
	10894826	10454	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	CHEMBL116542	10454	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	9884087	14605	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	CHEMBL120512	14605	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	71733935	90954	0	None	-457	6	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
	CHEMBL2396663	90954	0	None	-457	6	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
	1242	3586	27	None	-5	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2008.09.049
	935	3586	27	None	-5	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2008.09.049
	CHEMBL286080	3586	27	None	-5	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2008.09.049
	25110707	12575	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	2	3	3	4.7	Oc1cc2c(c(-c3ccc(Cl)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	CHEMBL1186974	12575	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	2	3	3	4.7	Oc1cc2c(c(-c3ccc(Cl)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	CHEMBL485036	12575	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	2	3	3	4.7	Oc1cc2c(c(-c3ccc(Cl)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	10594054	31383	1	None	-562	4	Bovine	5.7	pKi	=	5.7	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2cc(CN3CCN(c4ccccc4Cl)CC3)[nH]c2c1	10.1021/jm0009989
	CHEMBL140258	31383	1	None	-562	4	Bovine	5.7	pKi	=	5.7	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2cc(CN3CCN(c4ccccc4Cl)CC3)[nH]c2c1	10.1021/jm0009989
	14198600	101864	2	None	3	2	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	CHEMBL300778	101864	2	None	3	2	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	54583898	61581	0	None	-3801	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	417	7	0	4	3.3	C#Cc1ccc2c(c1)CCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
	CHEMBL1771114	61581	0	None	-3801	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	417	7	0	4	3.3	C#Cc1ccc2c(c1)CCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
	44412482	78130	0	None	-4365	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cnn(-c3ccccn3)c2)CC1	10.1016/j.bmcl.2006.02.075
	CHEMBL210404	78130	0	None	-4365	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cnn(-c3ccccn3)c2)CC1	10.1016/j.bmcl.2006.02.075
	17475863	168760	3	None	-660	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	CHEMBL437490	168760	3	None	-660	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	53317208	58525	0	None	-234	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	634	14	0	8	6.4	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCn2cc(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
	CHEMBL1684029	58525	0	None	-234	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	634	14	0	8	6.4	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCn2cc(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
	24854106	161037	1	None	-95	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
	CHEMBL411663	161037	1	None	-95	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
	10960333	206961	0	None	-2	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	398	5	0	6	3.5	CCOC(=O)c1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
	CHEMBL91362	206961	0	None	-2	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	398	5	0	6	3.5	CCOC(=O)c1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
	44339953	109673	0	None	-707	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
	CHEMBL322802	109673	0	None	-707	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
	21559988	113400	3	None	-30	4	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	389	5	1	3	4.0	O=C(CCC(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318852	113400	3	None	-30	4	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	389	5	1	3	4.0	O=C(CCC(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2014.06.079
	9797495	68975	0	None	-17378	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	328	3	0	4	2.9	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cc1	10.1021/jm200762g
	CHEMBL1923292	68975	0	None	-17378	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	328	3	0	4	2.9	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cc1	10.1021/jm200762g
	44381279	58709	0	None	-41	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
	CHEMBL168571	58709	0	None	-41	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
	44415837	139514	0	None	5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	3	1	5	5.9	CC(C)N1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL379593	139514	0	None	5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	3	1	5	5.9	CC(C)N1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	154724369	176665	1	None	-51	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	484	12	0	6	6.1	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4584372	176665	1	None	-51	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	484	12	0	6	6.1	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4598389	176665	1	None	-51	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	484	12	0	6	6.1	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	681	1453	72	None	-154	39	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
	940	1453	72	None	-154	39	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
	947	1453	72	None	-154	39	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
	CHEMBL59	1453	72	None	-154	39	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
	DB00988	1453	72	None	-154	39	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
	6603800	3522	11	None	1	2	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2c([C@@H](C1)c1ccccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
	956	3522	11	None	1	2	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2c([C@@H](C1)c1ccccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
	CHEMBL63321	3522	11	None	1	2	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2c([C@@H](C1)c1ccccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
	5281148	203886	50	None	5	4	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	260	8	2	2	2.8	C=C[C@@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC	10.1016/j.bmc.2007.12.021
	CHEMBL69018	203886	50	None	5	4	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	260	8	2	2	2.8	C=C[C@@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC	10.1016/j.bmc.2007.12.021
	14198585	100774	1	None	1	4	Rat	4.7	pKi	=	4.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL293158	100774	1	None	1	4	Rat	4.7	pKi	=	4.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
	44582705	186972	0	None	-12	13	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL490632	186972	0	None	-12	13	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	2351	3261	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	2820	3261	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	5035	3261	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	CHEMBL81	3261	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	DB00481	3261	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	12488	1644	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	941361	1644	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	CHEMBL30008	1644	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	DB04841	1644	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	10338282	34657	1	None	-2	6	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143022	34657	1	None	-2	6	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
	13678325	101893	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	313	8	2	3	4.4	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
	CHEMBL300995	101893	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	313	8	2	3	4.4	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
	6937303	203184	7	None	-43	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	335	4	0	4	4.1	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)cs2)cc1	10.1016/s0960-894x(00)00405-4
	CHEMBL64376	203184	7	None	-43	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	335	4	0	4	4.1	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)cs2)cc1	10.1016/s0960-894x(00)00405-4
	44278364	99392	0	None	-169	3	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	334	6	0	2	3.9	O=C1c2ccccc2CN1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
	CHEMBL282822	99392	0	None	-169	3	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	334	6	0	2	3.9	O=C1c2ccccc2CN1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
	68950	127513	12	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	8	0	2	4.0	CCN(CC)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
	CHEMBL366265	127513	12	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	8	0	2	4.0	CCN(CC)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
	191	402	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	201	402	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2170	402	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	CHEMBL1113	402	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	DB00543	402	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	242	469	124	None	-74	52	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
	34	469	124	None	-74	52	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
	60795	469	124	None	-74	52	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
	CHEMBL1112	469	124	None	-74	52	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
	DB01238	469	124	None	-74	52	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
	46931072	202022	1	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL608530	202022	1	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	15711870	12924	0	None	1	3	Goldfish	6.7	pKi	=	6.7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	CHEMBL1189332	12924	0	None	1	3	Goldfish	6.7	pKi	=	6.7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	CHEMBL538520	12924	0	None	1	3	Goldfish	6.7	pKi	=	6.7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	164610779	185059	0	None	-81	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	558	7	2	5	4.5	COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccc(I)c(OC)c1)CC2	10.1016/j.bmcl.2021.128047
	CHEMBL4855891	185059	0	None	-81	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	558	7	2	5	4.5	COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccc(I)c(OC)c1)CC2	10.1016/j.bmcl.2021.128047
	10046389	61386	0	None	-1122	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
	CHEMBL177031	61386	0	None	-1122	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
	15136	108083	2	None	-154	2	Rat	5.7	pKi	=	5.7	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
	CHEMBL319557	108083	2	None	-154	2	Rat	5.7	pKi	=	5.7	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
	44432812	87539	0	None	-5	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	3	2	3	3.4	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
	CHEMBL233567	87539	0	None	-5	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	3	2	3	3.4	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
	154703541	176275	1	None	-85	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	464	11	1	3	6.1	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4541924	176275	1	None	-85	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	464	11	1	3	6.1	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4595195	176275	1	None	-85	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	464	11	1	3	6.1	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	11186895	87478	25	None	-5	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmcl.2017.01.090
	CHEMBL2334885	87478	25	None	-5	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmcl.2017.01.090
	1353	1898	93	None	-74	86	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
	3559	1898	93	None	-74	86	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
	86	1898	93	None	-74	86	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
	CHEMBL54	1898	93	None	-74	86	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
	DB00502	1898	93	None	-74	86	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
	46231589	201278	0	None	999	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNc3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL604108	201278	0	None	999	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNc3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
	37459	743	13	None	-10	25	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127053
	62	743	13	None	-10	25	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127053
	CHEMBL8514	743	13	None	-10	25	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127053
	142405827	179841	0	None	-14	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	421	2	1	4	6.1	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(OC(F)(F)F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
	CHEMBL4745489	179841	0	None	-14	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	421	2	1	4	6.1	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(OC(F)(F)F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
	142405818	180835	0	None	34	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	367	2	1	4	5.2	COc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
	CHEMBL4757297	180835	0	None	34	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	367	2	1	4	5.2	COc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
	15937728	19963	0	None	288	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C(C2C=CCCC2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL130328	19963	0	None	288	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C(C2C=CCCC2)C1	10.1016/S0960-894X(00)80155-9
	11623343	140817	1	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL381936	140817	1	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	44415702	139874	0	None	87	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	2	1	5	5.4	Cc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
	CHEMBL379942	139874	0	None	87	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	2	1	5	5.4	Cc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
	16665071	93372	0	None	-8	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	334	1	0	3	3.8	COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL245764	93372	0	None	-8	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	334	1	0	3	3.8	COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1	10.1016/j.bmcl.2006.11.093
	10004036	95200	0	None	33	2	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
	CHEMBL256075	95200	0	None	33	2	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
	71563084	87542	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335736	87542	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	46231847	200551	0	None	3	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	343	1	2	3	3.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL599116	200551	0	None	3	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	343	1	2	3	3.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	6603950	203301	9	None	-6	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL64875	203301	9	None	-6	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	6603950	203301	9	None	-6	9	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	CHEMBL64875	203301	9	None	-6	9	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	16090814	81552	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
	CHEMBL216258	81552	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
	6603950	203301	9	None	-6	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL64875	203301	9	None	-6	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	10935201	20852	0	None	758	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.1	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCCC2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL131054	20852	0	None	758	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.1	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCCC2)C1	10.1016/S0960-894X(00)80155-9
	16090814	81552	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL216258	81552	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	134151764	153120	0	None	31	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	433	4	2	5	4.3	CCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3976659	153120	0	None	31	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	433	4	2	5	4.3	CCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	1238	203151	24	None	-5	17	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL64249	203151	24	None	-5	17	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	15115523	108842	1	None	691	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	346	1	2	3	3.4	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N)cc2)C1	10.1021/jm00115a012
	CHEMBL321042	108842	1	None	691	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	346	1	2	3	3.4	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N)cc2)C1	10.1021/jm00115a012
	11315462	200443	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)C4CC4)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL598516	200443	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)C4CC4)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	46231833	200888	0	None	218	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	384	2	2	3	4.3	CCC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	CHEMBL601634	200888	0	None	218	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	384	2	2	3	4.3	CCC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	142405825	179815	0	None	-24	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
	CHEMBL4745124	179815	0	None	-24	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
	134135947	144364	0	None	46	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	5	2	5	4.7	CCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3905947	144364	0	None	46	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	5	2	5	4.7	CCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	37459	743	13	None	-10	25	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2016.03.037
	62	743	13	None	-10	25	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2016.03.037
	CHEMBL8514	743	13	None	-10	25	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2016.03.037
	46231782	200480	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	371	1	1	4	3.8	COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
	CHEMBL598730	200480	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	371	1	1	4	3.8	COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
	46232064	201325	0	None	707	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	473	2	1	3	6.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(OC(F)(F)F)c4)c3CC[C@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL604383	201325	0	None	707	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	473	2	1	3	6.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(OC(F)(F)F)c4)c3CC[C@H]21	10.1016/j.bmcl.2009.12.094
	1238	203151	24	None	-5	17	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL64249	203151	24	None	-5	17	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	10662054	84383	0	None	151	2	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114444	84383	0	None	151	2	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219803	84383	0	None	151	2	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	146266	100670	8	None	2	4	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00118a012
	CHEMBL292418	100670	8	None	2	4	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00118a012
	CHEMBL540857	100670	8	None	2	4	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00118a012
	46231772	201286	0	None	371	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	CHEMBL604132	201286	0	None	371	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	162676091	183300	0	None	512	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	401	2	1	4	5.7	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(OC(F)(F)F)ccc1N2	10.1016/j.bmcl.2020.127563
	CHEMBL4797375	183300	0	None	512	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	401	2	1	4	5.7	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(OC(F)(F)F)ccc1N2	10.1016/j.bmcl.2020.127563
	75202022	170786	2	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL4453318	170786	2	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	10537185	25653	0	None	-12	2	Rat	8.6	pKi	=	8.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL135224	25653	0	None	-12	2	Rat	8.6	pKi	=	8.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	44415672	80145	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213492	80145	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	70690500	76044	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.12.016
	CHEMBL2057455	76044	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.12.016
	70690500	76044	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057455	76044	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	70690500	76044	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
	CHEMBL2057455	76044	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
	44415689	139084	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	494	2	2	6	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL378669	139084	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	494	2	2	6	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	46231846	201316	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	341	1	1	3	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL604316	201316	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	341	1	1	3	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	17755867	86080	1	None	-1	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
	CHEMBL231070	86080	1	None	-1	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
	9993922	59936	0	None	3	2	Rat	8.6	pKi	=	8.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	282	1	0	2	3.5	CN1CCc2cccc3c2C(C1)CN3c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
	CHEMBL173315	59936	0	None	3	2	Rat	8.6	pKi	=	8.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	282	1	0	2	3.5	CN1CCc2cccc3c2C(C1)CN3c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
	46231768	199457	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL591685	199457	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	11439190	201282	0	None	31	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	338	0	1	3	3.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL604127	201282	0	None	31	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	338	0	1	3	3.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	37461	17102	14	None	-3	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1016/j.bmcl.2021.128047
	CHEMBL1255588	17102	14	None	-3	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1016/j.bmcl.2021.128047
	44268688	166551	0	None	37	2	Rat	8.5	pKi	=	8.5	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
	CHEMBL427996	166551	0	None	37	2	Rat	8.5	pKi	=	8.5	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
	4350931	169289	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
	CHEMBL441618	169289	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
	4350931	169289	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
	CHEMBL441618	169289	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
	1353	1898	93	None	-74	86	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
	3559	1898	93	None	-74	86	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
	86	1898	93	None	-74	86	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
	CHEMBL54	1898	93	None	-74	86	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
	DB00502	1898	93	None	-74	86	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
	44331310	107339	1	None	25	3	Human	7.7	pKi	=	7.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9800292
	CHEMBL317741	107339	1	None	25	3	Human	7.7	pKi	=	7.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9800292
	44415649	138399	0	None	162	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
	CHEMBL377420	138399	0	None	162	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
	135398745	2893	112	None	-23	66	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
	47	2893	112	None	-23	66	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
	CHEMBL715	2893	112	None	-23	66	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
	DB00334	2893	112	None	-23	66	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
	10894826	10454	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	CHEMBL116542	10454	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
	10519435	171445	0	None	87	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL446350	171445	0	None	87	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	10015045	13620	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00004a011
	CHEMBL119455	13620	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00004a011
	10015045	13620	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960188q
	CHEMBL119455	13620	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960188q
	10015045	13620	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
	CHEMBL119455	13620	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
	16103	204615	47	None	-2	4	Rat	6.7	pKi	=	6.7	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00043a008
	CHEMBL73538	204615	47	None	-2	4	Rat	6.7	pKi	=	6.7	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00043a008
	155515982	169986	0	None	-794	17	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	CHEMBL4442460	169986	0	None	-794	17	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	56833464	68367	0	None	-99	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1138	38	2	16	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
	CHEMBL1916720	68367	0	None	-99	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1138	38	2	16	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
	14378574	108560	0	None	-7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(O)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
	CHEMBL320397	108560	0	None	-7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(O)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
	57390116	69269	0	None	-323	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928122	69269	0	None	-323	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
	118709175	113396	0	None	-107	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	474	10	0	5	4.9	CN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318848	113396	0	None	-107	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	474	10	0	5	4.9	CN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	10378194	197742	0	None	-338	6	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	265	3	1	2	2.3	C#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
	CHEMBL57176	197742	0	None	-338	6	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	265	3	1	2	2.3	C#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
	10862425	116607	0	None	-467	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccnn3c2)CC1	10.1021/jm025558r
	CHEMBL336930	116607	0	None	-467	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccnn3c2)CC1	10.1021/jm025558r
	10613676	13824	0	None	-165	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1021/jm060959i
	CHEMBL119593	13824	0	None	-165	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1021/jm060959i
	10092819	16741	0	None	-1412	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
	CHEMBL124444	16741	0	None	-1412	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
	52947756	17138	0	None	-478	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	567	6	0	2	8.3	O=C(CCCN1CCC(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
	CHEMBL1256170	17138	0	None	-478	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	567	6	0	2	8.3	O=C(CCCN1CCC(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
	44319368	106037	0	None	-7	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
	CHEMBL313320	106037	0	None	-7	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
	44319369	205796	0	None	-11	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
	CHEMBL83306	205796	0	None	-11	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
	44380802	161667	0	None	-131	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
	CHEMBL413343	161667	0	None	-131	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
	6469693	79926	17	None	-7079	6	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	322	4	0	5	2.7	COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1	10.1021/jm060166w
	CHEMBL212631	79926	17	None	-7079	6	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	322	4	0	5	2.7	COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1	10.1021/jm060166w
	44319369	205796	0	None	-11	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
	CHEMBL83306	205796	0	None	-11	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
	2247	504	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	504	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	504	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	504	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	504	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	24949857	181743	0	None	-7413	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
	CHEMBL477765	181743	0	None	-7413	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
	53318500	58520	0	None	-57	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	630	10	0	7	6.9	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
	CHEMBL1684024	58520	0	None	-57	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	630	10	0	7	6.9	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
	2993172	127141	4	None	1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	0	3	3.0	c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1	10.1021/jm049720x
	CHEMBL365697	127141	4	None	1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	0	3	3.0	c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1	10.1021/jm049720x
	134551	357	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	271	357	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	885	357	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	CHEMBL1403281	357	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	2105	3032	37	None	-537	33	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
	47811	3032	37	None	-537	33	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
	48	3032	37	None	-537	33	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
	CHEMBL531	3032	37	None	-537	33	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
	DB01186	3032	37	None	-537	33	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
	25212275	174397	0	None	-4897	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	CHEMBL455288	174397	0	None	-4897	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	25212276	190042	0	None	-575	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	CHEMBL517244	190042	0	None	-575	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	135446209	9553	58	None	-22	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	298	0	2	5	3.1	Cc1cc2c(s1)Nc1ccccc1N=C2N1CCNCC1	10.1016/S0960-894X(96)00567-7
	CHEMBL1125	9553	58	None	-22	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	298	0	2	5	3.1	Cc1cc2c(s1)Nc1ccccc1N=C2N1CCNCC1	10.1016/S0960-894X(96)00567-7
	71061709	149503	0	None	-14	12	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL3946540	149503	0	None	-14	12	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	44582113	181611	0	None	-169	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	364	6	0	4	2.7	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL477434	181611	0	None	-169	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	364	6	0	4	2.7	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
	10474964	130445	0	None	-8511	7	Bovine	5.7	pKi	=	5.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL368061	130445	0	None	-8511	7	Bovine	5.7	pKi	=	5.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL5206021	130445	0	None	-8511	7	Bovine	5.7	pKi	=	5.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	5353853	17954	47	None	-19	15	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	9556529	17954	47	None	-19	15	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1262	17954	47	None	-19	15	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	127262	13448	12	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	CHEMBL1193274	13448	12	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	46227325	200104	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2C1	10.1016/j.bmc.2009.08.028
	CHEMBL596179	200104	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2C1	10.1016/j.bmc.2009.08.028
	71474079	143239	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	CHEMBL3896731	143239	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	10550785	163408	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	433	4	1	2	5.9	Oc1cc2c(cc1Br)CCN(C/C=C/c1ccccc1)CC2c1ccccc1	10.1021/jm960143p
	CHEMBL419759	163408	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	433	4	1	2	5.9	Oc1cc2c(cc1Br)CCN(C/C=C/c1ccccc1)CC2c1ccccc1	10.1021/jm960143p
	53359025	62323	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	339	5	1	3	2.5	O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1	10.1016/j.bmcl.2011.04.098
	CHEMBL1779058	62323	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	339	5	1	3	2.5	O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1	10.1016/j.bmcl.2011.04.098
	6603703	208	10	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
	9637	208	10	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
	CHEMBL291143	208	10	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
	2389	3306	118	None	-489	68	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
	5073	3306	118	None	-489	68	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
	96	3306	118	None	-489	68	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
	CHEMBL85	3306	118	None	-489	68	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
	DB00734	3306	118	None	-489	68	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
	86764100	132451	30	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697617	132451	30	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	6603820	95745	19	None	-2	13	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
	CHEMBL25856	95745	19	None	-2	13	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
	135398737	955	93	None	-44	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
	38	955	93	None	-44	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
	722	955	93	None	-44	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
	CHEMBL42	955	93	None	-44	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
	DB00363	955	93	None	-44	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
	75201901	166401	19	None	-1	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166401	19	None	-1	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	17756101	98556	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
	CHEMBL276778	98556	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
	10903748	78447	0	None	-11	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL2111781	78447	0	None	-11	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	2435	3563	83	None	-72	49	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
	60149	3563	83	None	-72	49	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
	98	3563	83	None	-72	49	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
	CHEMBL12713	3563	83	None	-72	49	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
	DB06144	3563	83	None	-72	49	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
	228	444	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
	33	444	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
	6005	444	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
	CHEMBL53	444	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
	DB00714	444	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
	53364153	63811	0	None	-38	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	929	25	0	16	7.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCCCCCCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	CHEMBL1803023	63811	0	None	-38	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	929	25	0	16	7.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCCCCCCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	135398737	955	93	None	-83	92	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
	38	955	93	None	-83	92	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
	722	955	93	None	-83	92	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
	CHEMBL42	955	93	None	-83	92	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
	DB00363	955	93	None	-83	92	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
	52945819	17521	0	None	-14	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	354	6	0	3	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
	CHEMBL1258037	17521	0	None	-14	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	354	6	0	3	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
	127047996	139621	0	None	-46	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	303	8	3	5	2.3	COc1ccccc1OCCNCCc1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
	CHEMBL3797758	139621	0	None	-46	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	303	8	3	5	2.3	COc1ccccc1OCCNCCc1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
	137636351	155849	0	None	-602	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	459	7	1	6	4.0	O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
	CHEMBL4060403	155849	0	None	-602	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	459	7	1	6	4.0	O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
	25072002	156090	0	None	-1047	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4063235	156090	0	None	-1047	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	122189388	123217	0	None	-40	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	483	7	0	8	3.8	O=Cc1cnn2ccc(-n3cc(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
	CHEMBL3613874	123217	0	None	-40	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	483	7	0	8	3.8	O=Cc1cnn2ccc(-n3cc(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
	44300865	201972	0	None	-173	7	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/s0960-894x(02)00316-5
	CHEMBL60815	201972	0	None	-173	7	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/s0960-894x(02)00316-5
	44340302	9720	0	None	-3	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL113471	9720	0	None	-3	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	44340376	110619	0	None	-24	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL325818	110619	0	None	-24	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	54581963	61571	0	None	-7762	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	437	8	0	5	3.7	COc1ccc2c(c1)CCCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
	CHEMBL1771105	61571	0	None	-7762	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	437	8	0	5	3.7	COc1ccc2c(c1)CCCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
	44300865	201972	0	None	-173	7	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/j.bmcl.2006.02.075
	CHEMBL60815	201972	0	None	-173	7	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/j.bmcl.2006.02.075
	9980998	31004	0	None	-3981	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	CHEMBL139926	31004	0	None	-3981	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	CHEMBL2112911	31004	0	None	-3981	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	45273442	196428	0	None	-100	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	403	3	0	5	4.3	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
	CHEMBL563078	196428	0	None	-100	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	403	3	0	5	4.3	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
	44567594	172609	0	None	-34	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	339	4	2	4	4.0	CCCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
	CHEMBL449461	172609	0	None	-34	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	339	4	2	4	4.0	CCCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
	49783040	17658	0	None	-446	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	395	8	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1	10.1021/jm100899z
	CHEMBL1258494	17658	0	None	-446	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	395	8	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1	10.1021/jm100899z
	137660837	159056	0	None	-3019	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4097330	159056	0	None	-3019	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	11154555	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	5037	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	7671	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL2028019	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL3085826	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	DB06016	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	11154555	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
	5037	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
	7671	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
	CHEMBL2028019	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
	CHEMBL3085826	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
	DB06016	797	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
	15723715	13382	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	337	1	2	3	4.0	CN1CCc2c(Cl)c(O)c(O)c(Cl)c2C(c2ccccc2)C1	10.1021/jm00116a004
	CHEMBL1192815	13382	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	337	1	2	3	4.0	CN1CCc2c(Cl)c(O)c(O)c(Cl)c2C(c2ccccc2)C1	10.1021/jm00116a004
	CHEMBL544118	13382	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	337	1	2	3	4.0	CN1CCc2c(Cl)c(O)c(O)c(Cl)c2C(c2ccccc2)C1	10.1021/jm00116a004
	44316315	205496	0	None	-1318	5	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	215	2	0	3	2.1	CCCN1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
	CHEMBL80845	205496	0	None	-1318	5	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	215	2	0	3	2.1	CCCN1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
	44264622	97114	4	None	-72	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	327	3	0	5	2.7	Clc1ccc(N2CCN(Cc3cnc4ncccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	CHEMBL267853	97114	4	None	-72	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	327	3	0	5	2.7	Clc1ccc(N2CCN(Cc3cnc4ncccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	44412268	78338	9	None	-2089	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cn(-c4ccccc4)nn3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	CHEMBL211026	78338	9	None	-2089	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cn(-c4ccccc4)nn3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	72544789	93103	0	None	-912	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	363	9	0	7	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443010	93103	0	None	-912	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	363	9	0	7	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
	45379515	7424	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3[nH]c4ccccc4c3C21	10.1021/jm901291r
	CHEMBL1086789	7424	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3[nH]c4ccccc4c3C21	10.1021/jm901291r
	44448027	155006	0	None	2	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	481	4	0	5	4.1	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL401567	155006	0	None	2	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	481	4	0	5	4.1	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	12301195	199693	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.2	COc1ccc2c(c1)CCN1CCc3ccccc3C21	10.1016/j.bmc.2009.08.028
	CHEMBL593395	199693	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.2	COc1ccc2c(c1)CCN1CCc3ccccc3C21	10.1016/j.bmc.2009.08.028
	9817779	114406	0	None	-2	3	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	CHEMBL333246	114406	0	None	-2	3	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	10085633	119970	0	None	-3	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	290	4	1	3	2.4	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCOCC1)CC2	10.1016/0960-894X(95)00076-6
	CHEMBL349997	119970	0	None	-3	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	290	4	1	3	2.4	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCOCC1)CC2	10.1016/0960-894X(95)00076-6
	15654855	102636	0	None	4	2	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3cc(Cl)ccc32)CC1	10.1021/jm00067a009
	CHEMBL304493	102636	0	None	4	2	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3cc(Cl)ccc32)CC1	10.1021/jm00067a009
	2337	3232	77	None	-53	63	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	50	3232	77	None	-53	63	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	5002	3232	77	None	-53	63	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	CHEMBL716	3232	77	None	-53	63	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	DB01224	3232	77	None	-53	63	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	9927411	203030	0	None	-89	4	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
	CHEMBL63576	203030	0	None	-89	4	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
	CHEMBL4566600	213991	0	None	-1	6	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1	ChEMBL		None	None	None		Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12	10.6019/CHEMBL5212743
	CHEMBL4745071	213991	0	None	-1	6	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1	ChEMBL		None	None	None		Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12	10.6019/CHEMBL5212743
	112500026	132436	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)ncc(=O)n1C	nan
	CHEMBL3697602	132436	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)ncc(=O)n1C	nan
	118711262	113930	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1cccc(-c2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
	CHEMBL3325913	113930	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1cccc(-c2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
	9817779	114406	0	None	-2	3	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	CHEMBL333246	114406	0	None	-2	3	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
	168290235	192944	0	None	-1513	20	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5201074	192944	0	None	-1513	20	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222491	192944	0	None	-1513	20	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	9998826	120451	0	None	-33113	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
	CHEMBL354210	120451	0	None	-33113	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
	2389	3306	118	None	-346	68	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
	5073	3306	118	None	-346	68	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
	96	3306	118	None	-346	68	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
	CHEMBL85	3306	118	None	-346	68	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
	DB00734	3306	118	None	-346	68	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
	9884087	14605	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	CHEMBL120512	14605	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	44415624	80076	0	None	19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL213193	80076	0	None	19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	44415577	80116	0	None	20	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	436	2	1	7	3.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccon3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213372	80116	0	None	20	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	436	2	1	7	3.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccon3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	25142456	82377	2	None	-10	9	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
	CHEMBL217299	82377	2	None	-10	9	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
	439654	16466	39	None	9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL1235966	16466	39	None	9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
	21527771	70127	1	None	-8	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940404	70127	1	None	-8	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	10903748	78447	0	None	-11	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL2111781	78447	0	None	-11	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	10830234	100349	0	None	20	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL289867	100349	0	None	20	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	11186523	127485	0	None	-15	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL366164	127485	0	None	-15	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	44408818	140140	1	None	-12	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
	CHEMBL380330	140140	1	None	-12	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
	53361301	63812	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
	CHEMBL1803024	63812	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
	54585810	61574	0	None	-22	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3c(cccc3-c3ccccc3)C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771108	61574	0	None	-22	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3c(cccc3-c3ccccc3)C2=O)CC1	10.1016/j.bmcl.2010.12.083
	53361301	63812	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	CHEMBL1803024	63812	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	53364226	63816	0	None	-67	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	989	29	0	18	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	CHEMBL1803028	63816	0	None	-67	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	989	29	0	18	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	118709160	113379	0	None	-18	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	846	18	0	8	10.1	O=C(CCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318832	113379	0	None	-18	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	846	18	0	8	10.1	O=C(CCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	118709161	113380	0	None	-83	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	860	19	0	8	10.5	O=C(CCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318833	113380	0	None	-83	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	860	19	0	8	10.5	O=C(CCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	10524751	57324	0	None	-1	4	Bovine	5.7	pKi	=	5.7	Binding	Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	395	5	0	1	6.5	CCCN(CCC)C1CCC(=C(C#Cc2ccccc2)C#Cc2ccccc2)CC1	10.1021/jm991098z
	CHEMBL165171	57324	0	None	-1	4	Bovine	5.7	pKi	=	5.7	Binding	Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	395	5	0	1	6.5	CCCN(CCC)C1CCC(=C(C#Cc2ccccc2)C#Cc2ccccc2)CC1	10.1021/jm991098z
	11036641	31748	0	None	-147	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
	CHEMBL140612	31748	0	None	-147	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
	11517928	77074	0	None	-18	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	444	4	0	6	4.3	Clc1ccc(N2CCN(Cc3cn4nc(N5CCCCC5)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
	CHEMBL207543	77074	0	None	-18	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	444	4	0	6	4.3	Clc1ccc(N2CCN(Cc3cn4nc(N5CCCCC5)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
	15548770	66420	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	375	2	2	4	5.0	CN1CCc2cc(Sc3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	CHEMBL1802234	66420	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	375	2	2	4	5.0	CN1CCc2cc(Sc3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	CHEMBL1852041	66420	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	375	2	2	4	5.0	CN1CCc2cc(Sc3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	122181333	121848	0	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	366	8	1	2	3.8	CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590084	121848	0	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	366	8	1	2	3.8	CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	57402365	69266	0	None	-169	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	441	12	1	6	3.1	CCOCCOc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
	CHEMBL1928119	69266	0	None	-169	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	441	12	1	6	3.1	CCOCCOc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
	44270558	165264	0	None	-812	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
	CHEMBL423247	165264	0	None	-812	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
	44400553	70750	0	None	-2398	5	Pig	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL195083	70750	0	None	-2398	5	Pig	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	15467372	169086	0	None	-138	4	Bovine	4.7	pKi	=	4.7	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(99)00302-9
	CHEMBL440120	169086	0	None	-138	4	Bovine	4.7	pKi	=	4.7	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(99)00302-9
	44264644	204720	0	None	-1737	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	330	3	0	4	3.2	Clc1ccc(N2CCN(Cc3cnn4c3CCCC4)CC2)cc1	10.1016/s0960-894x(98)00692-1
	CHEMBL7442	204720	0	None	-1737	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	330	3	0	4	3.2	Clc1ccc(N2CCN(Cc3cnn4c3CCCC4)CC2)cc1	10.1016/s0960-894x(98)00692-1
	45269161	196312	0	None	-181	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	336	3	0	6	2.4	Cc1cc2nc(C)c(CN3CCN(c4ccccn4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
	CHEMBL562384	196312	0	None	-181	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	336	3	0	6	2.4	Cc1cc2nc(C)c(CN3CCN(c4ccccn4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
	46850462	76533	0	None	-16	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccccc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
	CHEMBL2062849	76533	0	None	-16	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccccc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
	46850464	76535	0	None	-87	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
	CHEMBL2062851	76535	0	None	-87	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
	5353432	97467	89	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
	CHEMBL270299	97467	89	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
	45481889	198992	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	637	10	2	10	5.4	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5nsc6ccccc56)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
	CHEMBL585741	198992	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	637	10	2	10	5.4	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5nsc6ccccc56)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
	90644062	112007	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289647	112007	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	90644062	112007	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289647	112007	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	44448065	155456	0	None	-2	2	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
	CHEMBL404037	155456	0	None	-2	2	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
	117773891	132399	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	379	5	1	6	3.1	Cc1cc(Oc2ncccc2OC2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697566	132399	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	379	5	1	6	3.1	Cc1cc(Oc2ncccc2OC2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	145979741	166661	1	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4282096	166661	1	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	46231835	200809	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	410	2	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCCCC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL600998	200809	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	410	2	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCCCC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL1200633	208577	3	None	-7	8	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
	112500027	132437	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
	CHEMBL3697603	132437	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
	44320257	206152	0	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86325	206152	0	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	49783209	17577	0	None	-3981	27	Rat	5.6	pKi	=	5.6	Binding	Binding affinity to rat dopamine D1 receptorBinding affinity to rat dopamine D1 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	CHEMBL1258223	17577	0	None	-3981	27	Rat	5.6	pKi	=	5.6	Binding	Binding affinity to rat dopamine D1 receptorBinding affinity to rat dopamine D1 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	19795148	116564	0	None	97	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	265	0	1	2	3.3	CN1CCc2cc(Cl)c(O)cc2C2(CCCC2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL336610	116564	0	None	97	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	265	0	1	2	3.3	CN1CCc2cc(Cl)c(O)cc2C2(CCCC2)C1	10.1016/S0960-894X(00)80155-9
	44447998	155369	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	363	6	0	3	5.3	CCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
	CHEMBL403550	155369	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	363	6	0	3	5.3	CCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
	44415844	80097	0	None	20	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3nccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213278	80097	0	None	20	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3nccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	17756102	86115	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	309	1	0	2	4.1	COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2	10.1021/jm070388+
	CHEMBL231171	86115	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	309	1	0	2	4.1	COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2	10.1021/jm070388+
	15069442	100673	0	None	104	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
	CHEMBL292451	100673	0	None	104	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
	71110293	143354	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	CHEMBL3897805	143354	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	71110293	143354	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	CHEMBL3897805	143354	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	70682088	76039	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057446	76039	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	117773010	132427	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.9	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C	nan
	CHEMBL3697593	132427	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.9	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C	nan
	10947658	28671	0	None	-208	16	Mouse	6.6	pKi	=	6.6	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL137781	28671	0	None	-208	16	Mouse	6.6	pKi	=	6.6	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	6603954	202582	2	None	-81	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL612083	202582	2	None	-81	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	11392229	62949	0	None	-15	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	293	1	0	3	2.9	Cc1ccc2n1Cc1ccccc1C=C2N1CCN(C)CC1	10.1021/jm049629t
	CHEMBL178564	62949	0	None	-15	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	293	1	0	3	2.9	Cc1ccc2n1Cc1ccccc1C=C2N1CCN(C)CC1	10.1021/jm049629t
	44360984	35051	0	None	-208	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1	10.1021/jm025558r
	CHEMBL143352	35051	0	None	-208	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1	10.1021/jm025558r
	11516033	139093	5	None	-1949	6	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	360	3	0	4	4.0	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1Cl	10.1021/jm060166w
	CHEMBL378680	139093	5	None	-1949	6	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	360	3	0	4	4.0	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1Cl	10.1021/jm060166w
	54583897	61572	0	None	-1445	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	411	7	0	4	3.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(F)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771106	61572	0	None	-1445	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	411	7	0	4	3.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(F)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	53363109	63818	0	None	-691	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	465	11	0	8	4.0	CCCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
	CHEMBL1803030	63818	0	None	-691	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	465	11	0	8	4.0	CCCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
	137660046	159319	0	None	-3235	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	437	7	2	8	2.4	O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1	10.1021/acs.jmedchem.7b00363
	CHEMBL4100183	159319	0	None	-3235	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	437	7	2	8	2.4	O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1	10.1021/acs.jmedchem.7b00363
	52937871	61142	0	None	-588	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	458	11	1	5	4.6	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(C=O)c2C1	10.1021/jm101639t
	CHEMBL1765631	61142	0	None	-588	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	458	11	1	5	4.6	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(C=O)c2C1	10.1021/jm101639t
	122177644	121186	0	None	-19054	6	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
	CHEMBL3577345	121186	0	None	-19054	6	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
	56926585	68976	0	None	-5495	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	358	4	0	5	2.9	COc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
	CHEMBL1923293	68976	0	None	-5495	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	358	4	0	5	2.9	COc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
	44381424	59041	0	None	-190	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
	CHEMBL169562	59041	0	None	-190	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
	44381432	120692	0	None	-6	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
	CHEMBL354748	120692	0	None	-6	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
	72301	186094	76	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL487182	186094	76	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	44591134	176176	0	None	-194	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	CHEMBL459373	176176	0	None	-194	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	154726381	176503	1	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4522558	176503	1	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4597048	176503	1	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	90644057	112005	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289645	112005	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	90644057	112005	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289645	112005	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	145992269	166929	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4287192	166929	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
	46227273	199788	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	3	0	2	3.8	COc1ccc2c(c1)CCN(C)C2Cc1ccccc1C	10.1016/j.bmc.2009.08.028
	CHEMBL594127	199788	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	3	0	2	3.8	COc1ccc2c(c1)CCN(C)C2Cc1ccccc1C	10.1016/j.bmc.2009.08.028
	135398737	955	93	None	-83	92	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
	38	955	93	None	-83	92	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
	722	955	93	None	-83	92	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
	CHEMBL42	955	93	None	-83	92	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
	DB00363	955	93	None	-83	92	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
	14198576	197865	0	None	-2	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	3	1	2	3.8	COc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
	CHEMBL572720	197865	0	None	-2	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	3	1	2	3.8	COc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
	228	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
	33	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
	6005	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
	CHEMBL53	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
	DB00714	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
	228	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
	33	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
	6005	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
	CHEMBL53	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
	DB00714	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
	228	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
	33	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
	6005	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
	CHEMBL53	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
	DB00714	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
	228	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
	33	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
	6005	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
	CHEMBL53	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
	DB00714	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
	44415613	78038	0	None	15	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	543	3	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCN(C)CC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL210016	78038	0	None	15	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	543	3	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCN(C)CC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	72708061	92170	0	None	-1	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
	CHEMBL2425372	92170	0	None	-1	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
	CHEMBL5274285	193782	0	None	-20	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constantDisplacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constant	ChEMBL	415	4	1	2	5.3	Fc1ccc(CN2CCCC23CCN(Cc2cc4ccc(Cl)cc4[nH]2)C3)cc1F	10.1016/j.ejmech.2022.114840
	44415645	139319	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	613	4	1	7	6.5	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc4c(c3)OCCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	CHEMBL379286	139319	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	613	4	1	7	6.5	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc4c(c3)OCCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	44209480	70141	0	None	-218	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940418	70141	0	None	-218	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	10264172	10401	0	None	-7413	2	Rat	4.6	pKi	=	4.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	2	2	3.1	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960188q
	CHEMBL116367	10401	0	None	-7413	2	Rat	4.6	pKi	=	4.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	2	2	3.1	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960188q
	3037308	44049	27	None	-99	6	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	452	7	1	7	4.2	O=c1c(CO)coc2cc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm9810396
	CHEMBL151475	44049	27	None	-99	6	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	452	7	1	7	4.2	O=c1c(CO)coc2cc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm9810396
	9928073	203626	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00030a011
	CHEMBL67284	203626	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00030a011
	10108504	38876	0	None	6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3ccccc3Oc3ncccc32)CC1	10.1021/jm00030a011
	CHEMBL146741	38876	0	None	6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3ccccc3Oc3ncccc32)CC1	10.1021/jm00030a011
	44582518	181569	0	None	-10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.6	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL477055	181569	0	None	-10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.6	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
	3036864	202731	19	None	-2	28	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1256645	202731	19	None	-2	28	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1814790	202731	19	None	-2	28	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL62	202731	19	None	-2	28	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	44385451	59562	0	None	-7	2	Rat	7.6	pKi	=	7.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	284	3	0	2	3.9	Cc1cccc2c1C(CN(C)C)CN2c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
	CHEMBL171903	59562	0	None	-7	2	Rat	7.6	pKi	=	7.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	284	3	0	2	3.9	Cc1cccc2c1C(CN(C)C)CN2c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
	13838745	94703	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
	CHEMBL25305	94703	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
	1353	1898	93	None	-74	86	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
	3559	1898	93	None	-74	86	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
	86	1898	93	None	-74	86	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
	CHEMBL54	1898	93	None	-74	86	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
	DB00502	1898	93	None	-74	86	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
	15937721	19073	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	255	2	1	3	2.6	CCOC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
	CHEMBL128917	19073	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	255	2	1	3	2.6	CCOC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
	44415670	138891	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	565	2	1	5	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL378341	138891	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	565	2	1	5	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	44415745	166298	0	None	25	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL427230	166298	0	None	25	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	86764211	132420	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697587	132420	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	90140334	129387	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc2n[nH]cc2c(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)n1	nan
	CHEMBL3671270	129387	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc2n[nH]cc2c(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)n1	nan
	44276535	98361	0	None	50	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	CHEMBL275379	98361	0	None	50	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	10432808	58719	0	None	-6	4	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
	CHEMBL168611	58719	0	None	-6	4	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
	2389	3306	118	None	-489	68	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	5073	3306	118	None	-489	68	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	96	3306	118	None	-489	68	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	CHEMBL85	3306	118	None	-489	68	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	DB00734	3306	118	None	-489	68	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	10042942	155478	0	None	3	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1OC)-c1c(OC)c(O)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL404136	155478	0	None	3	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1OC)-c1c(OC)c(O)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	137642380	158483	0	None	-48	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	431	6	1	5	4.2	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1	10.1021/acs.jmedchem.6b01857
	CHEMBL4091155	158483	0	None	-48	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	431	6	1	5	4.2	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1	10.1021/acs.jmedchem.6b01857
	90644227	111753	0	None	-186	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	448	8	1	6	4.1	OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287396	111753	0	None	-186	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	448	8	1	6	4.1	OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	228	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
	33	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
	6005	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
	CHEMBL53	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
	DB00714	444	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
	9928073	203626	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00067a009
	CHEMBL67284	203626	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00067a009
	53362716	63932	0	None	-26	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
	CHEMBL1806871	63932	0	None	-26	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
	49783039	17621	0	None	-954	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	421	7	1	4	4.9	Cc1ccc(C)c(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1	10.1021/jm100899z
	CHEMBL1258383	17621	0	None	-954	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	421	7	1	4	4.9	Cc1ccc(C)c(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1	10.1021/jm100899z
	57400557	69283	0	None	-1995	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	509	14	1	8	3.2	CCOCCOCc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
	CHEMBL1928136	69283	0	None	-1995	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	509	14	1	8	3.2	CCOCCOCc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
	15654854	102228	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cccnc3Nc3ccccc32)CC1	10.1021/jm00067a009
	CHEMBL303173	102228	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cccnc3Nc3ccccc32)CC1	10.1021/jm00067a009
	11589069	96218	0	None	-1479	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
	CHEMBL260994	96218	0	None	-1479	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
	15115513	108653	0	None	-218	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL320779	108653	0	None	-218	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	681	1453	72	None	-154	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	940	1453	72	None	-154	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	947	1453	72	None	-154	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	CHEMBL59	1453	72	None	-154	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	DB00988	1453	72	None	-154	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	44299917	169425	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@@H]21	10.1021/jm00128a038
	CHEMBL442740	169425	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@@H]21	10.1021/jm00128a038
	90134304	166490	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
	CHEMBL4278861	166490	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
	71562963	87547	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335741	87547	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	10691657	119888	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	387	3	0	3	5.1	CCCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
	CHEMBL349311	119888	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	387	3	0	3	5.1	CCCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
	168294767	192995	0	None	-457	20	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5207281	192995	0	None	-457	20	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222802	192995	0	None	-457	20	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	117773347	132401	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	378	4	1	6	2.8	Cc1cc(Oc2ncccc2N2CCC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697568	132401	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	378	4	1	6	2.8	Cc1cc(Oc2ncccc2N2CCC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	71110290	147135	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	CHEMBL3927835	147135	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	15711860	13826	0	None	-1	2	Goldfish	6.6	pKi	=	6.6	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
	CHEMBL1195937	13826	0	None	-1	2	Goldfish	6.6	pKi	=	6.6	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
	CHEMBL555619	13826	0	None	-1	2	Goldfish	6.6	pKi	=	6.6	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
	14198588	171483	2	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
	CHEMBL446396	171483	2	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
	44320001	205993	0	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84983	205993	0	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44591135	190153	0	None	-158	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	532	10	0	4	8.0	CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	CHEMBL517407	190153	0	None	-158	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	532	10	0	4	8.0	CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	71110293	143354	0	None	6	3	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	CHEMBL3897805	143354	0	None	6	3	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
	135398745	2893	112	None	-23	66	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
	47	2893	112	None	-23	66	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
	CHEMBL715	2893	112	None	-23	66	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
	DB00334	2893	112	None	-23	66	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
	1353	1898	93	None	-38	86	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
	3559	1898	93	None	-38	86	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
	86	1898	93	None	-38	86	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
	CHEMBL54	1898	93	None	-38	86	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
	DB00502	1898	93	None	-38	86	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
	1242	3586	27	None	-5	18	Human	7.6	pKi	=	7.6	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
	935	3586	27	None	-5	18	Human	7.6	pKi	=	7.6	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
	CHEMBL286080	3586	27	None	-5	18	Human	7.6	pKi	=	7.6	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
	75306277	109227	0	None	-12	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	CHEMBL3217984	109227	0	None	-12	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	9884087	14605	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	CHEMBL120512	14605	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	71474026	154275	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
	CHEMBL3986624	154275	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
	11718008	75262	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL203734	75262	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	44415954	81072	0	None	72	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	467	6	1	5	5.4	CCCC(CCC)C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	CHEMBL215581	81072	0	None	72	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	467	6	1	5	5.4	CCCC(CCC)C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	135398745	2893	112	None	-26	66	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
	47	2893	112	None	-26	66	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
	CHEMBL715	2893	112	None	-26	66	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
	DB00334	2893	112	None	-26	66	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
	53364154	63813	0	None	-13	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1013	31	0	16	9.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	CHEMBL1803025	63813	0	None	-13	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1013	31	0	16	9.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	45273443	195608	0	None	-66	4	Bovine	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	392	4	1	6	2.2	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
	CHEMBL556288	195608	0	None	-66	4	Bovine	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	392	4	1	6	2.2	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
	137644966	158470	0	None	-363	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	456	6	1	6	4.1	N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
	CHEMBL4091064	158470	0	None	-363	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	456	6	1	6	4.1	N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
	122191607	123696	0	None	-346	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	468	9	1	3	5.0	CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1	10.1021/acsmedchemlett.5b00131
	CHEMBL3622099	123696	0	None	-346	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	468	9	1	3	5.0	CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1	10.1021/acsmedchemlett.5b00131
	56837636	69268	0	None	-177	5	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	897	28	2	13	5.1	COc1ccccc1N1CCN(CCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928121	69268	0	None	-177	5	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	897	28	2	13	5.1	COc1ccccc1N1CCN(CCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
	44401042	124803	0	None	-67	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL364270	124803	0	None	-67	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	11575799	78100	0	None	-2511	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	438	3	0	4	4.7	Clc1ccc(N2CCN(Cc3cn4cc(Br)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
	CHEMBL210341	78100	0	None	-2511	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	438	3	0	4	4.7	Clc1ccc(N2CCN(Cc3cn4cc(Br)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
	25256814	181588	0	None	-1318	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL477250	181588	0	None	-1318	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	53363110	63821	0	None	-194	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	507	14	0	8	4.8	CCCCn1cc(CCCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
	CHEMBL1803050	63821	0	None	-194	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	507	14	0	8	4.8	CCCCn1cc(CCCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
	24823922	160769	0	None	-15	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
	CHEMBL411437	160769	0	None	-15	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
	11725531	54024	2	None	-1659	5	Bovine	5.6	pKi	=	5.6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	351	3	0	5	3.2	N#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
	CHEMBL160626	54024	2	None	-1659	5	Bovine	5.6	pKi	=	5.6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	351	3	0	5	3.2	N#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
	15522515	98133	0	None	-1479	4	Bovine	4.6	pKi	=	4.6	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	292	3	0	4	2.7	c1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	CHEMBL273860	98133	0	None	-1479	4	Bovine	4.6	pKi	=	4.6	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	292	3	0	4	2.7	c1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	71734028	91024	0	None	-7762	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
	CHEMBL2397390	91024	0	None	-7762	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
	2389	3306	118	None	-346	68	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
	5073	3306	118	None	-346	68	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
	96	3306	118	None	-346	68	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
	CHEMBL85	3306	118	None	-346	68	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
	DB00734	3306	118	None	-346	68	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
	44320002	107014	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315535	107014	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44582491	181531	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	6	0	4	3.3	COc1ccccc1N1CCN(CCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL476641	181531	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	6	0	4	3.3	COc1ccccc1N1CCN(CCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
	10022123	53286	0	None	-28	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm981094e
	CHEMBL159969	53286	0	None	-28	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm981094e
	CHEMBL92673	53286	0	None	-28	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm981094e
	71562966	87544	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
	CHEMBL2335738	87544	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
	44478261	192273	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	0	3	6	3.0	CN1CCc2c3c(cc4nc(N)sc24)-c2c(ccc(O)c2O)C[C@H]31	10.1016/j.bmc.2008.05.077
	CHEMBL520610	192273	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	0	3	6	3.0	CN1CCc2c3c(cc4nc(N)sc24)-c2c(ccc(O)c2O)C[C@H]31	10.1016/j.bmc.2008.05.077
	175	3628	44	None	-831	7	Mouse	5.6	pKi	=	5.6	Binding	Tested for binding affinity against dopamine receptor D1Tested for binding affinity against dopamine receptor D1	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00069a010
	68186	3628	44	None	-831	7	Mouse	5.6	pKi	=	5.6	Binding	Tested for binding affinity against dopamine receptor D1Tested for binding affinity against dopamine receptor D1	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00069a010
	CHEMBL79834	3628	44	None	-831	7	Mouse	5.6	pKi	=	5.6	Binding	Tested for binding affinity against dopamine receptor D1Tested for binding affinity against dopamine receptor D1	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00069a010
	145988779	167255	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
	CHEMBL4293356	167255	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
	72164182	92121	0	None	-41	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	3	0	3	4.4	Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl	10.1016/j.bmcl.2013.07.033
	CHEMBL2420777	92121	0	None	-41	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	3	0	3	4.4	Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl	10.1016/j.bmcl.2013.07.033
	10092819	16741	0	None	-2454	12	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm0211220
	CHEMBL124444	16741	0	None	-2454	12	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm0211220
	44415647	139215	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	639	5	1	6	7.6	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	CHEMBL378893	139215	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	639	5	1	6	7.6	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	164612037	185353	0	None	-144	20	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	CHEMBL4860528	185353	0	None	-144	20	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	57396484	70140	2	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	316	6	0	5	2.2	Fc1ccc(OCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940417	70140	2	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	316	6	0	5	2.2	Fc1ccc(OCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	13015797	205874	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	400	6	0	5	3.7	COc1cc2c(cc1OC)C(CCN1CCN(c3ccc(F)cc3)CC1)OCC2	10.1021/jm960084f
	CHEMBL83915	205874	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	400	6	0	5	3.7	COc1cc2c(cc1OC)C(CCN1CCN(c3ccc(F)cc3)CC1)OCC2	10.1021/jm960084f
	44415836	80107	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	4	1	5	5.9	CCCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL213335	80107	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	4	1	5	5.9	CCCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	70607606	177180	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	333	1	3	3	3.1	Oc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL4635277	177180	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	333	1	3	3	3.1	Oc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
	6852376	91570	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
	CHEMBL1467585	91570	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
	CHEMBL24077	91570	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
	CHEMBL503958	91570	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
	72699812	115160	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	315	2	1	4	3.7	CCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	CHEMBL3344456	115160	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	315	2	1	4	3.7	CCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	10566865	115953	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL335515	115953	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	10015045	13620	1	None	-2	6	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
	CHEMBL119455	13620	1	None	-2	6	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
	86764215	132431	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697597	132431	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	14198587	203108	1	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm00129a006
	CHEMBL64117	203108	1	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm00129a006
	11728201	13947	0	None	-7	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL119687	13947	0	None	-7	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	9884087	14605	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL120512	14605	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	15115514	9039	0	None	-54	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL109897	9039	0	None	-54	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	90644061	112006	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289646	112006	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	136056636	111761	0	None	-309	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287404	111761	0	None	-309	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	118709174	113395	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	946	23	0	10	9.6	CN(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)CCN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318847	113395	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	946	23	0	10	9.6	CN(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)CCN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	10917953	207965	0	None	-7585	10	Rat	5.6	pKi	=	5.6	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	489	6	0	8	3.6	Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
	CHEMBL97242	207965	0	None	-7585	10	Rat	5.6	pKi	=	5.6	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	489	6	0	8	3.6	Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
	71583849	87703	0	None	-147	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(-n2cc(CN3CCN(c4cc5ccc4CCc4ccc(cc4)CC5)CC3)cn2)cc1	10.1016/j.bmc.2013.01.065
	CHEMBL2336893	87703	0	None	-147	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(-n2cc(CN3CCN(c4cc5ccc4CCc4ccc(cc4)CC5)CC3)cn2)cc1	10.1016/j.bmc.2013.01.065
	14659268	79609	2	None	-35	3	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1016/j.bmc.2008.02.038
	CHEMBL2115032	79609	2	None	-35	3	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1016/j.bmc.2008.02.038
	122180956	121745	0	None	-263	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	404	7	1	3	4.8	CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3589577	121745	0	None	-263	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	404	7	1	3	4.8	CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	122177641	121183	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
	CHEMBL3577342	121183	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
	72544566	93102	0	None	-1318	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	375	10	0	6	3.1	COc1ccccc1N1CCN(Cc2cn(CCCCCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443009	93102	0	None	-1318	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	375	10	0	6	3.1	COc1ccccc1N1CCN(Cc2cn(CCCCCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
	9865384	173471	35	None	-30902	7	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm100835q
	CHEMBL45305	173471	35	None	-30902	7	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm100835q
	10014924	107244	0	None	-1548	5	Bovine	4.6	pKi	=	4.6	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL316983	107244	0	None	-1548	5	Bovine	4.6	pKi	=	4.6	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
	11472028	66737	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	1	3	3.2	OC(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
	CHEMBL185875	66737	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	1	3	3.2	OC(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
	15711855	13380	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	CHEMBL1192799	13380	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	CHEMBL544099	13380	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	11696813	187894	12	None	-316	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm100294b
	CHEMBL496739	187894	12	None	-316	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm100294b
	90644061	112006	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289646	112006	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	72708126	92173	0	None	-7	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425375	92173	0	None	-7	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	14198588	171483	2	None	2	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
	CHEMBL446396	171483	2	None	2	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
	57401706	70142	0	None	-45	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940419	70142	0	None	-45	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	44320218	206401	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
	CHEMBL87897	206401	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
	10993765	78738	0	None	-36	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	433	5	0	5	4.1	COc1ccccc1N1CCN(CC2CCN(C(=O)c3cc4ccccc4o3)CC2)CC1	10.1021/jm0211220
	CHEMBL2112643	78738	0	None	-36	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	433	5	0	5	4.1	COc1ccccc1N1CCN(CC2CCN(C(=O)c3cc4ccccc4o3)CC2)CC1	10.1021/jm0211220
	91899757	129414	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-n1c(C)nc2cnccc21	nan
	CHEMBL3671296	129414	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-n1c(C)nc2cnccc21	nan
	1971	2846	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	2404	2846	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	4543	2846	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	CHEMBL445	2846	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	DB00540	2846	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	25256816	181584	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL477206	181584	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
	9884087	14605	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	CHEMBL120512	14605	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
	21533446	70126	0	None	-7	10	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940403	70126	0	None	-7	10	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	11728201	13947	0	None	-7	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL119687	13947	0	None	-7	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	9884087	14605	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL120512	14605	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	70684965	77805	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL2092940	77805	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	1353	1898	93	None	-38	86	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
	3559	1898	93	None	-38	86	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
	86	1898	93	None	-38	86	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
	CHEMBL54	1898	93	None	-38	86	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
	DB00502	1898	93	None	-38	86	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
	44249745	195420	1	None	-363	6	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2010.09.142
	CHEMBL552373	195420	1	None	-363	6	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2010.09.142
	CHEMBL567286	195420	1	None	-363	6	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2010.09.142
	24878061	141386	0	None	25	2	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
	CHEMBL384046	141386	0	None	25	2	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
	10061323	11874	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL118254	11874	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
	53364227	63817	0	None	-50	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1033	32	0	19	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	CHEMBL1803029	63817	0	None	-50	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1033	32	0	19	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	10061323	11874	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
	CHEMBL118254	11874	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
	11405107	199040	0	None	-32	4	Bovine	5.6	pKi	=	5.6	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	341	3	1	2	3.7	C(#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1)c1ccccc1	10.1016/s0960-894x(02)00316-5
	CHEMBL58662	199040	0	None	-32	4	Bovine	5.6	pKi	=	5.6	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	341	3	1	2	3.7	C(#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1)c1ccccc1	10.1016/s0960-894x(02)00316-5
	44403210	70514	0	None	-630	5	Pig	5.6	pKi	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	385	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
	CHEMBL194727	70514	0	None	-630	5	Pig	5.6	pKi	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	385	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
	9970201	170619	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
	CHEMBL445129	170619	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
	52938728	58524	0	None	-1000	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
	CHEMBL1684028	58524	0	None	-1000	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
	137636066	156209	0	None	-1698	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	480	7	3	7	3.0	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	CHEMBL4064742	156209	0	None	-1698	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	480	7	3	7	3.0	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	4150	785	39	None	-69	12	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
	5288	785	39	None	-69	12	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
	644019	785	39	None	-69	12	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
	CHEMBL190461	785	39	None	-69	12	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
	DB09061	785	39	None	-69	12	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
	11689612	79810	0	None	-28840	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	388	5	0	7	2.9	COc1ccccc1N1CCN(Cc2cn3c(-n4cccn4)cccc3n2)CC1	10.1021/jm060166w
	CHEMBL212160	79810	0	None	-28840	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	388	5	0	7	2.9	COc1ccccc1N1CCN(Cc2cn3c(-n4cccn4)cccc3n2)CC1	10.1021/jm060166w
	44412269	78071	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2006.02.075
	CHEMBL210232	78071	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2006.02.075
	44412269	78071	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL210232	78071	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	45271653	195212	0	None	-2238	4	Bovine	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)ncn34)CC2)cc1	10.1016/j.bmc.2009.05.015
	CHEMBL550920	195212	0	None	-2238	4	Bovine	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)ncn34)CC2)cc1	10.1016/j.bmc.2009.05.015
	10046389	61386	0	None	-1122	5	Bovine	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
	CHEMBL177031	61386	0	None	-1122	5	Bovine	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
	135	2515	43	None	-91	58	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	1796	2515	43	None	-91	58	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	4184	2515	43	None	-91	58	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	CHEMBL6437	2515	43	None	-91	58	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	DB06148	2515	43	None	-91	58	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	44406077	132793	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
	CHEMBL370136	132793	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
	90644071	112015	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	368	5	0	3	5.2	Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289655	112015	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	368	5	0	3	5.2	Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
	131396	206712	6	None	-549	5	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligandCompound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligand	ChEMBL	435	6	0	5	4.6	CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1	10.1021/jm00092a024
	CHEMBL89934	206712	6	None	-549	5	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligandCompound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligand	ChEMBL	435	6	0	5	4.6	CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1	10.1021/jm00092a024
	118711255	113926	0	None	-26	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(NCc3cccc(Cl)c3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	CHEMBL3325905	113926	0	None	-26	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(NCc3cccc(Cl)c3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	45269964	13589	0	None	-30	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	309	2	2	3	3.9	CCCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL1194295	13589	0	None	-30	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	309	2	2	3	3.9	CCCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL550180	13589	0	None	-30	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	309	2	2	3	3.9	CCCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	10825256	10146	0	None	-6	3	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	260	0	0	2	3.3	CN1CCc2cccc3c2[C@H]1Cc1cccc(C#N)c1-3	10.1021/jm960189i
	CHEMBL115969	10146	0	None	-6	3	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	260	0	0	2	3.3	CN1CCc2cccc3c2[C@H]1Cc1cccc(C#N)c1-3	10.1021/jm960189i
	44432811	87538	0	None	-5	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	323	3	1	3	4.2	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1016/j.bmcl.2007.05.057
	CHEMBL233566	87538	0	None	-5	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	323	3	1	3	4.2	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1016/j.bmcl.2007.05.057
	44366021	121001	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
	CHEMBL356597	121001	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
	44415559	80134	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213444	80134	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	44415673	139219	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	545	4	1	7	6.1	CCOc1c(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)sc2ccccc12	10.1016/j.bmcl.2006.06.022
	CHEMBL378914	139219	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	545	4	1	7	6.1	CCOc1c(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)sc2ccccc12	10.1016/j.bmcl.2006.06.022
	16104	161893	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
	CHEMBL415300	161893	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
	74223830	129424	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
	CHEMBL3671305	129424	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
	16104	161893	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
	CHEMBL415300	161893	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
	17755999	142860	1	None	-5	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
	CHEMBL389357	142860	1	None	-5	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
	86767095	129401	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	345	3	1	5	4.1	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
	CHEMBL3671284	129401	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	345	3	1	5	4.1	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
	10566865	115953	0	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL335515	115953	0	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	44408818	140140	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
	CHEMBL380330	140140	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
	44408818	140140	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2006.11.093
	CHEMBL380330	140140	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2006.11.093
	44408818	140140	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmc.2009.08.028
	CHEMBL380330	140140	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmc.2009.08.028
	45379370	7491	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1	10.1021/jm901291r
	CHEMBL1087301	7491	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1	10.1021/jm901291r
	10090424	34667	1	None	-3	6	Rat	7.5	pKi	=	7.5	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143027	34667	1	None	-3	6	Rat	7.5	pKi	=	7.5	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
	70692656	76046	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL2057457	76046	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.12.016
	70692656	76046	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	CHEMBL2057457	76046	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	70692656	76046	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
	CHEMBL2057457	76046	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
	70692656	76046	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
	CHEMBL2057457	76046	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
	44276651	99712	0	None	32	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL284959	99712	0	None	32	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	15225749	80656	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	341	0	1	5	3.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(N)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL215140	80656	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	341	0	1	5	3.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(N)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	137651073	157444	0	None	-53	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4079301	157444	0	None	-53	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	118709162	113381	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	874	20	0	8	10.9	O=C(CCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318834	113381	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	874	20	0	8	10.9	O=C(CCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	10689581	100135	0	None	1	2	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL287931	100135	0	None	1	2	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	44380770	165688	0	None	-91	4	Bovine	5.6	pKi	=	5.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
	CHEMBL424575	165688	0	None	-91	4	Bovine	5.6	pKi	=	5.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
	11706497	78148	0	None	-776	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	535	7	1	3	6.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
	CHEMBL210461	78148	0	None	-776	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	535	7	1	3	6.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
	56833379	68305	0	None	-234	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1155	37	2	18	8.6	COc1cc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
	CHEMBL1916550	68305	0	None	-234	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1155	37	2	18	8.6	COc1cc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
	44340415	8546	0	None	-3	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL109472	8546	0	None	-3	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
	127045854	139539	0	None	-218	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	CHEMBL3797205	139539	0	None	-218	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	127046949	139884	0	None	-446	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	472	12	3	5	4.6	COc1cc(CCNCCc2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	CHEMBL3799455	139884	0	None	-446	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	472	12	3	5	4.6	COc1cc(CCNCCc2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	24936042	157565	0	None	-218	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4080762	157565	0	None	-218	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
	57390115	69267	0	None	-575	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.4	CCOCCOc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
	CHEMBL1928120	69267	0	None	-575	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.4	CCOCCOc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
	24824065	97923	0	None	-1	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
	CHEMBL272602	97923	0	None	-1	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
	10404144	205279	23	None	-2187	10	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
	CHEMBL7927	205279	23	None	-2187	10	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
	14198593	198651	1	None	4	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
	CHEMBL57988	198651	1	None	4	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
	14198594	200080	1	None	6	2	Human	6.6	pKi	=	6.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNC[C@H]2c1ccccc1	10.1021/jm00129a006
	CHEMBL59603	200080	1	None	6	2	Human	6.6	pKi	=	6.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNC[C@H]2c1ccccc1	10.1021/jm00129a006
	44582178	181235	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	378	6	0	4	3.1	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL476185	181235	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	378	6	0	4	3.1	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
	9951008	206374	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm981094e
	CHEMBL87717	206374	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm981094e
	9951008	206374	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm00042a009
	CHEMBL87717	206374	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm00042a009
	3561	19045	39	None	-1	11	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
	CHEMBL1289	19045	39	None	-1	11	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
	15711852	13307	0	None	-6	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	CHEMBL1192193	13307	0	None	-6	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	CHEMBL543389	13307	0	None	-6	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	5041	3269	6	None	-11220	6	Human	5.6	pKi	=	5.6	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	465	6	0	4	4.6	CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C	10.1021/acs.jmedchem.7b00151
	981	3269	6	None	-11220	6	Human	5.6	pKi	=	5.6	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	465	6	0	4	4.6	CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C	10.1021/acs.jmedchem.7b00151
	CHEMBL4096543	3269	6	None	-11220	6	Human	5.6	pKi	=	5.6	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	465	6	0	4	4.6	CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C	10.1021/acs.jmedchem.7b00151
	15711851	13508	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
	CHEMBL1193797	13508	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
	CHEMBL545264	13508	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
	14198586	201810	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
	CHEMBL60706	201810	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
	91899758	129415	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cc(=O)[nH]nc1C	nan
	CHEMBL3671297	129415	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cc(=O)[nH]nc1C	nan
	117773787	132415	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.7	Cc1cc(Oc2ncccc2C2COC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697582	132415	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.7	Cc1cc(Oc2ncccc2C2COC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	10333195	48156	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
	CHEMBL155208	48156	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
	1353	1898	93	None	-74	86	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
	3559	1898	93	None	-74	86	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
	86	1898	93	None	-74	86	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
	CHEMBL54	1898	93	None	-74	86	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
	DB00502	1898	93	None	-74	86	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
	103	4122	61	None	-28	54	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
	2875	4122	61	None	-28	54	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
	5736	4122	61	None	-28	54	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
	CHEMBL285802	4122	61	None	-28	54	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
	DB09225	4122	61	None	-28	54	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
	10379766	4874	0	None	14	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.2	CCc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
	CHEMBL104571	4874	0	None	14	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.2	CCc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
	17755999	142860	1	None	-5	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1021/jm070388+
	CHEMBL389357	142860	1	None	-5	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1021/jm070388+
	86767097	129403	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	359	3	1	5	4.5	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
	CHEMBL3671286	129403	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	359	3	1	5	4.5	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
	135398737	955	93	None	-44	92	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
	38	955	93	None	-44	92	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
	722	955	93	None	-44	92	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
	CHEMBL42	955	93	None	-44	92	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
	DB00363	955	93	None	-44	92	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
	10472143	119251	0	None	-645	16	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL343755	119251	0	None	-645	16	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	11777127	25778	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	CHEMBL135318	25778	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	228	444	28	None	-35	24	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
	33	444	28	None	-35	24	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
	6005	444	28	None	-35	24	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
	CHEMBL53	444	28	None	-35	24	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
	DB00714	444	28	None	-35	24	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
	10154	142104	59	None	-58	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
	CHEMBL388342	142104	59	None	-58	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
	9980998	31004	0	None	-3981	8	Human	5.5	pKi	=	5.5	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm025558r
	CHEMBL139926	31004	0	None	-3981	8	Human	5.5	pKi	=	5.5	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm025558r
	CHEMBL2112911	31004	0	None	-3981	8	Human	5.5	pKi	=	5.5	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm025558r
	11697270	77281	0	None	-3467	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	412	5	0	5	4.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1	10.1021/jm060166w
	CHEMBL208274	77281	0	None	-3467	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	412	5	0	5	4.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1	10.1021/jm060166w
	44340376	110619	0	None	-24	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL325818	110619	0	None	-24	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	25256816	181584	0	None	-4466	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL477206	181584	0	None	-4466	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	16754	85545	50	None	-67	7	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL228082	85545	50	None	-67	7	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	25139181	184318	0	None	-1513	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	414	10	1	2	5.7	C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm800895v
	CHEMBL484358	184318	0	None	-1513	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	414	10	1	2	5.7	C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm800895v
	44567587	178211	0	None	-66	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	311	2	2	4	3.2	CCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
	CHEMBL465055	178211	0	None	-66	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	311	2	2	4	3.2	CCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
	127046951	139877	0	None	-61	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	CHEMBL3799427	139877	0	None	-61	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	137633705	156594	0	None	-5370	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	474	7	2	7	4.0	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1	10.1021/acs.jmedchem.6b01857
	CHEMBL4069091	156594	0	None	-5370	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	474	7	2	7	4.0	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1	10.1021/acs.jmedchem.6b01857
	122177645	121187	0	None	-13803	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
	CHEMBL3577346	121187	0	None	-13803	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
	57391897	69280	0	None	-301	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	481	12	1	8	2.7	CCOCCOc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
	CHEMBL1928133	69280	0	None	-301	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	481	12	1	8	2.7	CCOCCOc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
	57393634	69290	0	None	-26	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1cc(COCCOCCOCCOCCOCc2ccc(N3CCN(CCCCNC(=O)c4ccccc4)CC3)c(OC)c2)ccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928248	69290	0	None	-26	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1cc(COCCOCCOCCOCCOCc2ccc(N3CCN(CCCCNC(=O)c4ccccc4)CC3)c(OC)c2)ccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1	10.1016/j.bmc.2011.10.063
	24824063	97973	11	None	-5	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cc4ccccn4n3)CC2)cc1	10.1021/jm701375u
	CHEMBL272853	97973	11	None	-5	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cc4ccccn4n3)CC2)cc1	10.1021/jm701375u
	44381216	120306	0	None	-19054	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
	CHEMBL352925	120306	0	None	-19054	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
	44329314	207919	0	None	-69	3	Bovine	4.5	pKi	=	4.5	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL96958	207919	0	None	-69	3	Bovine	4.5	pKi	=	4.5	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
	154706546	176422	1	None	-63	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4452329	176422	1	None	-63	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4596339	176422	1	None	-63	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
	17755991	152274	0	None	1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	267	0	2	2	3.1	Oc1ccc2c(c1)CCCNCCc1ccccc1C2	10.1021/jm070388+
	CHEMBL396950	152274	0	None	1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	267	0	2	2	3.1	Oc1ccc2c(c1)CCCNCCc1ccccc1C2	10.1021/jm070388+
	96918	12458	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
	CHEMBL1186488	12458	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
	118711257	113928	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccccc1CNc1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
	CHEMBL3325907	113928	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccccc1CNc1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
	44568534	174292	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	265	0	2	3	2.6	CN1CCc2cc(N)cc3c2[C@H]1Cc1cccc(N)c1-3	10.1016/j.bmc.2008.05.077
	CHEMBL455051	174292	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	265	0	2	3	2.6	CN1CCc2cc(N)cc3c2[C@H]1Cc1cccc(N)c1-3	10.1016/j.bmc.2008.05.077
	10438027	66158	0	None	-954	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
	CHEMBL184383	66158	0	None	-954	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
	44415805	81506	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	561	4	1	5	7.1	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(CC3CCCCC3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	CHEMBL216047	81506	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	561	4	1	5	7.1	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(CC3CCCCC3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	96918	12458	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
	CHEMBL1186488	12458	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
	154704705	176301	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	11	1	6	4.9	CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4590356	176301	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	11	1	6	4.9	CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4595409	176301	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	11	1	6	4.9	CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	10367486	9262	1	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
	CHEMBL110948	9262	1	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
	CHEMBL543613	9262	1	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
	1042	1568	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	148	1568	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	443884	1568	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	CHEMBL119443	1568	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	DB01253	1568	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	72708126	92173	0	None	-7	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425375	92173	0	None	-7	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	71450550	83778	0	None	-6	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to D1 dopamine receptorBinding affinity to D1 dopamine receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	CHEMBL2205836	83778	0	None	-6	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to D1 dopamine receptorBinding affinity to D1 dopamine receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	736083	162190	17	None	-50	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	CHEMBL416288	162190	17	None	-50	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	10452020	118249	3	None	10	3	Human	8.5	pKi	=	8.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm9800292
	CHEMBL34095	118249	3	None	10	3	Human	8.5	pKi	=	8.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm9800292
	10516818	25619	0	None	2	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL135197	25619	0	None	2	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	122324	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00114a002
	6077	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00114a002
	CHEMBL86931	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00114a002
	10467946	48439	4	None	-1	4	Bovine	8.5	pKi	=	8.5	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
	CHEMBL155596	48439	4	None	-1	4	Bovine	8.5	pKi	=	8.5	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
	14809027	107002	0	None	257	4	Rat	8.5	pKi	=	8.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315468	107002	0	None	257	4	Rat	8.5	pKi	=	8.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	122324	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	6077	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	CHEMBL86931	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	44415690	80108	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	CHEMBL213336	80108	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	44415690	80108	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	CHEMBL213336	80108	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	44415506	80210	0	None	169	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
	CHEMBL213793	80210	0	None	169	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
	46231845	200710	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	391	0	1	2	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL600083	200710	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	391	0	1	2	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	1153	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	12668023	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	30026874	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	30026875	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	3341	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	6603851	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	933	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	939	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	985	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	CHEMBL1160786	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	CHEMBL1161520	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	CHEMBL588	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	DB00800	1615	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
	44401164	69787	0	None	-19	9	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL193639	69787	0	None	-19	9	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	11573628	74670	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
	CHEMBL203047	74670	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
	46231848	200515	0	None	8	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	396	1	1	3	4.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL598949	200515	0	None	8	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	396	1	1	3	4.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	3038603	101838	8	None	2	3	Human	8.5	pKi	=	8.5	Binding	The compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligandThe compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligand	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
	CHEMBL300647	101838	8	None	2	3	Human	8.5	pKi	=	8.5	Binding	The compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligandThe compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligand	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
	86763997	132447	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697613	132447	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	11778580	66097	1	None	-5	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	0	1	3	2.9	CN1CCOc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm049720x
	CHEMBL184050	66097	1	None	-5	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	0	1	3	2.9	CN1CCOc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm049720x
	11493746	141298	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL383451	141298	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
	17755867	86080	1	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm070388+
	CHEMBL231070	86080	1	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm070388+
	44415704	80130	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	474	2	2	6	4.4	Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	CHEMBL213424	80130	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	474	2	2	6	4.4	Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	15937717	20615	0	None	346	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	253	2	1	2	3.4	CCCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
	CHEMBL130851	20615	0	None	346	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	253	2	1	2	3.4	CCCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
	56944383	112092	0	None	-6	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3290012	112092	0	None	-6	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	9861622	199421	5	None	1202	2	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	10.1021/jm00128a038
	CHEMBL59139	199421	5	None	1202	2	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	10.1021/jm00128a038
	44415723	141755	0	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL386122	141755	0	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	6917970	3665	61	None	-1	34	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.12.016
	8370	3665	61	None	-1	34	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.12.016
	CHEMBL487387	3665	61	None	-1	34	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.12.016
	11079319	131774	1	None	-13	3	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	1	0	4	3.9	CN1CCN(C2=Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm0309811
	CHEMBL369367	131774	1	None	-13	3	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	1	0	4	3.9	CN1CCN(C2=Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm0309811
	5249956	73366	1	None	-4	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
	CHEMBL201525	73366	1	None	-4	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
	44415536	138605	0	None	95	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(I)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL377584	138605	0	None	95	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(I)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	117774127	132397	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697564	132397	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	142405812	180979	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	381	3	1	4	5.6	CCOc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
	CHEMBL4758966	180979	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	381	3	1	4	5.6	CCOc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
	15937730	18919	0	None	478	2	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	301	1	1	2	3.9	CN1CCc2cc(Cl)c(O)cc2C(C2C=CC=CC=C2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL128649	18919	0	None	478	2	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	301	1	1	2	3.9	CN1CCc2cc(Cl)c(O)cc2C(C2C=CC=CC=C2)C1	10.1016/S0960-894X(00)80155-9
	44439945	93338	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2cc(O)ccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL245571	93338	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2cc(O)ccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
	71474025	145302	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	CHEMBL3913343	145302	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	71474025	145302	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	CHEMBL3913343	145302	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	44561317	188950	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	1	2	3.4	CCN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
	CHEMBL508399	188950	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	1	2	3.4	CCN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
	44415593	80218	0	None	-3	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213834	80218	0	None	-3	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	6603703	208	10	None	1	5	Pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysisDisplacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysis	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1016/j.ejmech.2020.113073
	9637	208	10	None	1	5	Pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysisDisplacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysis	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1016/j.ejmech.2020.113073
	CHEMBL291143	208	10	None	1	5	Pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysisDisplacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysis	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1016/j.ejmech.2020.113073
	12668019	10207	8	None	204	3	Human	7.5	pKi	=	7.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/jm9800292
	CHEMBL1160787	10207	8	None	204	3	Human	7.5	pKi	=	7.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/jm9800292
	44415338	155732	0	None	69	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	579	3	1	7	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnn(-c4ccccc4)c3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL405751	155732	0	None	69	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	579	3	1	7	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnn(-c4ccccc4)c3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	6603703	208	10	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	9637	208	10	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	CHEMBL291143	208	10	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	74223723	129389	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	334	3	1	4	4.6	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
	CHEMBL3671272	129389	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	334	3	1	4	4.6	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
	44320378	206040	0	None	25	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85409	206040	0	None	25	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	86764212	132422	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	4	4.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697589	132422	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	4	4.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	9949441	114435	0	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	CHEMBL333455	114435	0	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	53364155	63814	0	None	-27	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1041	33	0	16	10.2	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCCc1cn(CCCCCCCCCCn2cc(CCCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	CHEMBL1803026	63814	0	None	-27	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1041	33	0	16	10.2	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCCc1cn(CCCCCCCCCCn2cc(CCCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	71733932	91023	0	None	-416	6	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
	CHEMBL2397389	91023	0	None	-416	6	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
	145988693	167142	0	None	-12	17	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL4291048	167142	0	None	-12	17	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	10310103	107285	0	None	-776	9	Rat	5.5	pKi	=	5.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	425	5	0	5	5.3	N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
	CHEMBL317333	107285	0	None	-776	9	Rat	5.5	pKi	=	5.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	425	5	0	5	5.3	N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
	3038495	705	37	None	-2041	19	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
	7625	705	37	None	-2041	19	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
	CHEMBL25236	705	37	None	-2041	19	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
	44436600	91773	0	None	-3019	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2007.08.038
	CHEMBL241212	91773	0	None	-3019	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2007.08.038
	44340227	110614	0	None	-2137	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL325772	110614	0	None	-2137	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
	10663221	33683	1	None	-60	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4)CC3)c2c1	10.1021/jm0009989
	CHEMBL142217	33683	1	None	-60	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4)CC3)c2c1	10.1021/jm0009989
	11983282	138918	0	None	-5128	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	315	4	0	3	4.2	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1	10.1016/j.bmcl.2006.02.075
	CHEMBL378455	138918	0	None	-5128	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	315	4	0	3	4.2	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1	10.1016/j.bmcl.2006.02.075
	10333195	48156	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
	CHEMBL155208	48156	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
	25128757	103277	0	None	-831	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	383	3	1	3	5.6	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1csc2ccccc12	10.1021/jm800532x
	CHEMBL3084512	103277	0	None	-831	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	383	3	1	3	5.6	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1csc2ccccc12	10.1021/jm800532x
	44448058	155180	0	None	2	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
	CHEMBL402517	155180	0	None	2	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
	72545007	93093	0	None	-199	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	407	12	0	8	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443000	93093	0	None	-199	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	407	12	0	8	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
	24824060	155691	0	None	-12	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
	CHEMBL405292	155691	0	None	-12	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
	10404663	166837	10	None	-1000	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	334	9	1	3	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)ccc1OC	10.1016/j.bmc.2007.07.017
	CHEMBL428561	166837	10	None	-1000	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	334	9	1	3	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)ccc1OC	10.1016/j.bmc.2007.07.017
	12050198	200231	0	None	-87	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	347	6	1	4	4.1	c1ccc(CN2CCC(NCc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
	CHEMBL59702	200231	0	None	-87	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	347	6	1	4	4.1	c1ccc(CN2CCC(NCc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
	156012196	177308	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	296	1	2	4	2.7	COc1cc2c3c(c1O)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4637246	177308	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	296	1	2	4	2.7	COc1cc2c3c(c1O)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	46227242	199907	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	2	1	2	3.5	Cc1ccccc1CC1c2ccc(O)cc2CCN1C	10.1016/j.bmc.2009.08.028
	CHEMBL594798	199907	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	2	1	2	3.5	Cc1ccccc1CC1c2ccc(O)cc2CCN1C	10.1016/j.bmc.2009.08.028
	10809507	119658	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(OC)cc(Br)c2C1Cc1ccccc1O	10.1021/jm991034o
	CHEMBL347243	119658	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(OC)cc(Br)c2C1Cc1ccccc1O	10.1021/jm991034o
	76314268	106407	0	None	-2630	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3115577	106407	0	None	-2630	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3139633	106407	0	None	-2630	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	188249	39623	4	None	-2	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm00030a011
	CHEMBL147463	39623	4	None	-2	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm00030a011
	CHEMBL2022280	39623	4	None	-2	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm00030a011
	15654862	203628	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ccncc32)CC1	10.1021/jm00067a009
	CHEMBL67298	203628	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ccncc32)CC1	10.1021/jm00067a009
	15654863	203414	0	None	7	2	Rat	5.5	pKi	=	5.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ccncc32)CC1	10.1021/jm00067a009
	CHEMBL65768	203414	0	None	7	2	Rat	5.5	pKi	=	5.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ccncc32)CC1	10.1021/jm00067a009
	15654861	100714	0	None	3	2	Rat	4.5	pKi	=	4.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ncccc32)CC1	10.1021/jm00067a009
	CHEMBL292738	100714	0	None	3	2	Rat	4.5	pKi	=	4.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ncccc32)CC1	10.1021/jm00067a009
	44591099	176166	0	None	-1122	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	CHEMBL459350	176166	0	None	-1122	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	9796958	146553	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
	CHEMBL2115374	146553	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
	CHEMBL39230	146553	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
	CHEMBL544814	146553	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
	CHEMBL3215298	211208	13	None	-6	2	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(C=C[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(C=C[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
	681	1453	72	None	-97	39	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
	940	1453	72	None	-97	39	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
	947	1453	72	None	-97	39	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
	CHEMBL59	1453	72	None	-97	39	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
	DB00988	1453	72	None	-97	39	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
	10474964	130445	0	None	-8511	7	Bovine	5.5	pKi	=	5.5	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL368061	130445	0	None	-8511	7	Bovine	5.5	pKi	=	5.5	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL5206021	130445	0	None	-8511	7	Bovine	5.5	pKi	=	5.5	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	10693836	9305	0	None	-19	4	Rat	5.5	pKi	=	5.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
	CHEMBL111189	9305	0	None	-19	4	Rat	5.5	pKi	=	5.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
	CHEMBL545488	9305	0	None	-19	4	Rat	5.5	pKi	=	5.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
	44579031	189811	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	391	8	0	3	6.1	CCCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
	CHEMBL516580	189811	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	391	8	0	3	6.1	CCCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
	44415835	139769	0	None	181	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
	CHEMBL379875	139769	0	None	181	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
	45271622	13999	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	357	2	2	3	4.9	CCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL1197278	13999	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	357	2	2	3	4.9	CCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL564909	13999	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	357	2	2	3	4.9	CCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	134147903	149403	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	383	6	2	5	4.3	CCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3945856	149403	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	383	6	2	5	4.3	CCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	9949441	114435	0	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	CHEMBL333455	114435	0	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	117774096	132404	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	5	3.7	Cc1cc(Oc2ncccc2C(C)C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697571	132404	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	5	3.7	Cc1cc(Oc2ncccc2C(C)C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	135398737	955	93	None	-44	92	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
	38	955	93	None	-44	92	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
	722	955	93	None	-44	92	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
	CHEMBL42	955	93	None	-44	92	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
	DB00363	955	93	None	-44	92	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
	64638	106114	2	None	40	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313530	106114	2	None	40	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44320053	205750	0	None	257	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL82899	205750	0	None	257	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	44319976	106936	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
	CHEMBL315005	106936	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
	11186895	87478	25	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
	CHEMBL2334885	87478	25	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
	242	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
	34	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
	60795	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
	CHEMBL1112	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
	DB01238	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
	242	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	34	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	60795	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	CHEMBL1112	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	DB01238	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	242	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	34	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	60795	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	CHEMBL1112	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	DB01238	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	242	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	34	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	60795	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL1112	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	DB01238	469	124	None	-281	52	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	44436599	91772	0	None	-257	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
	CHEMBL241211	91772	0	None	-257	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
	136043855	141503	0	None	-389	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	482	2	1	6	5.6	FC1(F)Oc2cccc(CN3CCN(C4=Nc5cc(Cl)ccc5Nc5ccccc54)CC3)c2O1	10.1016/j.bmcl.2006.06.034
	CHEMBL384634	141503	0	None	-389	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	482	2	1	6	5.6	FC1(F)Oc2cccc(CN3CCN(C4=Nc5cc(Cl)ccc5Nc5ccccc54)CC3)c2O1	10.1016/j.bmcl.2006.06.034
	127031949	138730	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	317	7	2	5	2.8	COc1cc(CCN(C)Cc2cccc(O)c2OC)ccc1O	10.1016/j.bmc.2016.03.037
	CHEMBL3780438	138730	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	317	7	2	5	2.8	COc1cc(CCN(C)Cc2cccc(O)c2OC)ccc1O	10.1016/j.bmc.2016.03.037
	4189	206899	96	None	-25	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206899	96	None	-25	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206899	96	None	-25	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	117773625	132387	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.4	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2)c(C)c(=O)[nH]c1=O	nan
	CHEMBL3697554	132387	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.4	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2)c(C)c(=O)[nH]c1=O	nan
	44319988	206056	0	None	3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85552	206056	0	None	3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	156012433	177290	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	326	2	1	5	3.1	COc1cc2c3c(c1O)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4636948	177290	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	326	2	1	5	3.1	COc1cc2c3c(c1O)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	1353	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
	3559	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
	86	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
	CHEMBL54	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
	DB00502	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
	135398737	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
	38	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
	722	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
	CHEMBL42	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
	DB00363	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
	3246545	202451	1	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL1573438	202451	1	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL611207	202451	1	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	1353	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
	3559	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
	86	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
	CHEMBL54	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
	DB00502	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
	1353	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
	3559	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
	86	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
	CHEMBL54	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
	DB00502	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
	1353	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
	3559	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
	86	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
	CHEMBL54	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
	DB00502	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
	1353	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
	3559	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
	86	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
	CHEMBL54	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
	DB00502	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
	1353	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
	3559	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
	86	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
	CHEMBL54	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
	DB00502	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
	44319915	205942	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84557	205942	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44415848	79880	0	None	40	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212438	79880	0	None	40	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	134150852	151671	0	None	12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	461	6	2	5	5.1	CCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3964242	151671	0	None	12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	461	6	2	5	5.1	CCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	86764320	132443	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
	CHEMBL3697609	132443	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
	15711869	13308	0	None	-6	6	Goldfish	7.5	pKi	=	7.5	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	CHEMBL1192194	13308	0	None	-6	6	Goldfish	7.5	pKi	=	7.5	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	CHEMBL543390	13308	0	None	-6	6	Goldfish	7.5	pKi	=	7.5	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	6852376	91570	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
	CHEMBL1467585	91570	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
	CHEMBL24077	91570	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
	CHEMBL503958	91570	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
	71109986	150609	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
	CHEMBL3955446	150609	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
	54585811	61580	0	None	-2454	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	418	7	0	5	3.2	COc1ccccc1N1CCN(CCCCN2CCc3cc(C#N)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771113	61580	0	None	-2454	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	418	7	0	5	3.2	COc1ccccc1N1CCN(CCCCN2CCc3cc(C#N)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	49783042	17659	0	None	-112	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	1	3	4.3	Cc1ccc(C)c(C(=O)NCCCCN2CCN(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
	CHEMBL1258495	17659	0	None	-112	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	1	3	4.3	Cc1ccc(C)c(C(=O)NCCCCN2CCN(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
	10871118	206784	0	None	-489	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccn4nccc34)CC2)cc1	10.1021/jm015522j
	CHEMBL90374	206784	0	None	-489	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccn4nccc34)CC2)cc1	10.1021/jm015522j
	10667043	28518	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	7	2	3	4.6	NCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL137637	28518	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	7	2	3	4.6	NCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	44537929	198057	0	None	-53	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(O)c(Cl)cc21	10.1016/j.bmc.2009.05.079
	CHEMBL574296	198057	0	None	-53	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(O)c(Cl)cc21	10.1016/j.bmc.2009.05.079
	2470	3626	50	None	-4168	60	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
	3300	3626	50	None	-4168	60	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
	5265	3626	50	None	-4168	60	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
	99	3626	50	None	-4168	60	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
	CHEMBL267930	3626	50	None	-4168	60	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
	15021876	103383	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm00111a046
	CHEMBL308480	103383	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm00111a046
	15021876	103383	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm981094e
	CHEMBL308480	103383	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm981094e
	10093238	207594	0	None	-1	3	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	414	8	0	5	3.9	O=C(CCCN1CCN(CCC2Cc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
	CHEMBL95112	207594	0	None	-1	3	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	414	8	0	5	3.9	O=C(CCCN1CCN(CCC2Cc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
	10738913	204940	0	None	-5	5	Rat	4.5	pKi	=	4.5	Binding	Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.	ChEMBL	386	8	2	5	1.5	CCOC(=O)c1[nH]c2ccc(CCN3C(=O)CNC3=O)cc2c1CCN(C)C	10.1021/jm9605849
	CHEMBL76480	204940	0	None	-5	5	Rat	4.5	pKi	=	4.5	Binding	Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.	ChEMBL	386	8	2	5	1.5	CCOC(=O)c1[nH]c2ccc(CCN3C(=O)CNC3=O)cc2c1CCN(C)C	10.1021/jm9605849
	73356845	92175	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
	CHEMBL2425377	92175	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
	235224	128129	29	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
	CHEMBL36654	128129	29	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
	45481864	198111	0	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	2	2	3.5	Oc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
	CHEMBL574695	198111	0	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	2	2	3.5	Oc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
	2402	3345	62	None	-74	25	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
	5095	3345	62	None	-74	25	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
	7295	3345	62	None	-74	25	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
	CHEMBL589	3345	62	None	-74	25	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
	DB00268	3345	62	None	-74	25	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
	44320328	206205	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
	CHEMBL86669	206205	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
	11696813	187894	12	None	-316	9	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm800689g
	CHEMBL496739	187894	12	None	-316	9	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm800689g
	73356845	92175	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
	CHEMBL2425377	92175	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
	6603820	95745	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
	CHEMBL25856	95745	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
	6603820	95745	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL25856	95745	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	15937720	116848	0	None	81	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	271	2	1	3	3.3	CCSC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
	CHEMBL338237	116848	0	None	81	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	271	2	1	3	3.3	CCSC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
	86763999	132450	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.5	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2C)n(C)c(=O)[nH]c1=O	nan
	CHEMBL3697616	132450	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.5	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2C)n(C)c(=O)[nH]c1=O	nan
	45483269	196936	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	426	4	0	7	4.1	CSc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
	CHEMBL566508	196936	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	426	4	0	7	4.1	CSc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
	44396220	125397	1	None	-1	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	2	4.1	c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1	10.1021/jm049720x
	CHEMBL364565	125397	1	None	-1	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	2	4.1	c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1	10.1021/jm049720x
	90666899	109418	0	None	-6	7	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	381	3	1	4	4.2	Cc1nc2c(o1)CC(CN1CCC(c3c[nH]c4cc(F)ccc34)CC1)CC2=O	10.1039/C1MD00202C
	CHEMBL3220215	109418	0	None	-6	7	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	381	3	1	4	4.2	Cc1nc2c(o1)CC(CN1CCC(c3c[nH]c4cc(F)ccc34)CC1)CC2=O	10.1039/C1MD00202C
	2865	4112	73	None	-114	54	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
	59	4112	73	None	-114	54	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
	60854	4112	73	None	-114	54	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
	CHEMBL708	4112	73	None	-114	54	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
	DB00246	4112	73	None	-114	54	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
	511482	97223	6	None	-251	5	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	325	3	1	2	4.1	Clc1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	CHEMBL268799	97223	6	None	-251	5	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	325	3	1	2	4.1	Clc1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	46917637	68303	0	None	-275	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1053	34	1	15	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(CN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
	CHEMBL1916548	68303	0	None	-275	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1053	34	1	15	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(CN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
	44417647	82132	0	None	1	2	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	CHEMBL1203924	82132	0	None	1	2	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	CHEMBL216945	82132	0	None	1	2	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	44400519	133104	0	None	-549	5	Pig	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL370297	133104	0	None	-549	5	Pig	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	10438027	66158	0	None	-1096	6	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1016/j.bmcl.2004.05.052
	CHEMBL184383	66158	0	None	-1096	6	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1016/j.bmcl.2004.05.052
	44381147	58699	0	None	-93	4	Bovine	5.5	pKi	=	5.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
	CHEMBL168544	58699	0	None	-93	4	Bovine	5.5	pKi	=	5.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
	44340415	8546	0	None	-3	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL109472	8546	0	None	-3	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
	44340333	9630	0	None	-1071	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL112833	9630	0	None	-1071	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
	122181330	121845	0	None	-3890	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590081	121845	0	None	-3890	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	44372153	120138	0	None	-89	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	416	4	0	4	5.3	Cc1nn2c(-c3ccccc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
	CHEMBL351550	120138	0	None	-89	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	416	4	0	4	5.3	Cc1nn2c(-c3ccccc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
	71734127	91028	0	None	-6760	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
	CHEMBL2397476	91028	0	None	-6760	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
	10247561	97976	0	None	-3	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
	CHEMBL272873	97976	0	None	-3	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
	118711252	113923	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(N)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	CHEMBL3325901	113923	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(N)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	71562965	87545	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
	CHEMBL2335739	87545	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
	24829343	158997	0	None	-4265	9	Human	5.5	pKi	=	5.5	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
	CHEMBL409662	158997	0	None	-4265	9	Human	5.5	pKi	=	5.5	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
	112500031	132442	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	0	5	4.3	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)cnc(=O)n1C	nan
	CHEMBL3697608	132442	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	0	5	4.3	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)cnc(=O)n1C	nan
	70682090	76040	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	CHEMBL2057451	76040	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
	70682090	76040	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
	CHEMBL2057451	76040	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
	72708128	92176	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
	CHEMBL2425378	92176	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
	11154555	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	5037	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	7671	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	CHEMBL2028019	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	CHEMBL3085826	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	DB06016	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	2105	3032	37	None	-537	33	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	47811	3032	37	None	-537	33	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	48	3032	37	None	-537	33	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	CHEMBL531	3032	37	None	-537	33	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	DB01186	3032	37	None	-537	33	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	86764215	132431	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697597	132431	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	10537185	25653	0	None	-12	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	CHEMBL135224	25653	0	None	-12	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
	86767087	129390	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	318	3	1	4	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnn1C	nan
	CHEMBL3671273	129390	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	318	3	1	4	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnn1C	nan
	9948254	108242	0	None	-141	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm00402a024
	CHEMBL31973	108242	0	None	-141	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm00402a024
	15115515	108579	0	None	-47	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL320526	108579	0	None	-47	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
	167715	2856	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
	969	2856	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
	CHEMBL225230	2856	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
	53317727	57913	0	None	-14	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	313	3	1	3	3.5	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
	CHEMBL1672313	57913	0	None	-14	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	313	3	1	3	3.5	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
	11121216	30108	0	None	-169	14	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL138989	30108	0	None	-169	14	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	167715	2856	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00105a005
	969	2856	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00105a005
	CHEMBL225230	2856	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00105a005
	44395741	181557	0	None	-23	10	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm100899z
	CHEMBL476935	181557	0	None	-23	10	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm100899z
	CHEMBL558392	181557	0	None	-23	10	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm100899z
	56597938	3909	3	None	-870	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	7651	3909	3	None	-870	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	CHEMBL2165126	3909	3	None	-870	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	167715	2856	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
	969	2856	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
	CHEMBL225230	2856	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
	44454734	97699	0	None	-912	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2ccc(OCCF)cc2)CC1	10.1016/j.bmcl.2007.12.026
	CHEMBL271513	97699	0	None	-912	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2ccc(OCCF)cc2)CC1	10.1016/j.bmcl.2007.12.026
	25130816	187687	0	None	-4786	3	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	490	8	2	5	5.8	CCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	CHEMBL495327	187687	0	None	-4786	3	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	490	8	2	5	5.8	CCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	45483654	198095	0	None	-14	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7cccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)c7)nn6)cc5)cc4)nn3)c2)CC1	10.1021/jm901120h
	CHEMBL574569	198095	0	None	-14	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7cccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)c7)nn6)cc5)cc4)nn3)c2)CC1	10.1021/jm901120h
	2779264	111315	38	None	-30	4	Bovine	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	240	3	0	2	3.3	c1ccc(CN2CCC(n3cccc3)CC2)cc1	10.1016/s0960-894x(99)00540-5
	CHEMBL326877	111315	38	None	-30	4	Bovine	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	240	3	0	2	3.3	c1ccc(CN2CCC(n3cccc3)CC2)cc1	10.1016/s0960-894x(99)00540-5
	42605994	17842	0	None	-16	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(Br)cs3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259071	17842	0	None	-16	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(Br)cs3)CC2)nc1	10.1021/jm100835q
	11566745	74665	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL1202298	74665	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL203029	74665	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	167715	2856	14	None	-954	5	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
	969	2856	14	None	-954	5	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
	CHEMBL225230	2856	14	None	-954	5	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
	11154555	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	5037	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	7671	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	CHEMBL2028019	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	CHEMBL3085826	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	DB06016	797	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
	7077	66929	27	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
	CHEMBL186720	66929	27	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
	CHEMBL3925724	66929	27	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
	3158	56237	27	None	-2398	20	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL1628227	56237	27	None	-2398	20	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	72708128	92176	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
	CHEMBL2425378	92176	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
	117774393	132432	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	307	3	1	4	3.5	Cc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c1	nan
	CHEMBL3697598	132432	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	307	3	1	4	3.5	Cc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c1	nan
	44588898	12571	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	331	2	3	3	4.0	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	CHEMBL1186959	12571	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	331	2	3	3	4.0	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	CHEMBL484352	12571	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	331	2	3	3	4.0	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	25256815	189530	0	None	-51	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	397	6	0	3	3.9	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL514382	189530	0	None	-51	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	397	6	0	3	3.9	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2009.01.067
	10833201	168587	0	None	-	1	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	373	2	0	3	4.7	CCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
	CHEMBL436042	168587	0	None	-	1	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	373	2	0	3	4.7	CCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
	10707972	169032	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
	CHEMBL439639	169032	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
	72708127	92174	0	None	-40	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425376	92174	0	None	-40	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
	13091359	113512	0	None	-489	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321790	113512	0	None	-489	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	112500033	132445	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
	CHEMBL3697611	132445	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
	118711265	113932	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	345	2	2	3	4.4	CN1CCc2cc(-c3ccc(O)cc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	CHEMBL3325916	113932	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	345	2	2	3	4.4	CN1CCc2cc(-c3ccc(O)cc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	44415551	80280	0	None	269	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL214142	80280	0	None	269	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	2726	916	68	None	-18	73	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
	621	916	68	None	-18	73	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
	83	916	68	None	-18	73	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
	CHEMBL71	916	68	None	-18	73	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
	DB00477	916	68	None	-18	73	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
	6852376	91570	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL1467585	91570	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL24077	91570	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL503958	91570	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	2726	916	68	None	-18	73	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
	621	916	68	None	-18	73	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
	83	916	68	None	-18	73	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
	CHEMBL71	916	68	None	-18	73	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
	DB00477	916	68	None	-18	73	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
	10402378	66095	0	None	-19	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	1	0	3	3.2	COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2	10.1021/jm049720x
	CHEMBL184049	66095	0	None	-19	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	1	0	3	3.2	COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2	10.1021/jm049720x
	86764105	132457	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	3	1	5	3.6	Cc1cc(Sc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697623	132457	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	3	1	5	3.6	Cc1cc(Sc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	6603820	95745	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2009.08.028
	CHEMBL25856	95745	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2009.08.028
	90140110	129412	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cn[nH]c(=O)c1C	nan
	CHEMBL3671294	129412	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cn[nH]c(=O)c1C	nan
	70690499	76042	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057453	76042	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
	70690499	76042	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.12.016
	CHEMBL2057453	76042	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.12.016
	135398737	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
	38	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
	722	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
	CHEMBL42	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
	DB00363	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
	24882561	95312	0	None	-2041	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	408	8	0	5	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
	CHEMBL256637	95312	0	None	-2041	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	408	8	0	5	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
	44403225	70519	0	None	-346	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	421	9	1	5	2.7	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
	CHEMBL194755	70519	0	None	-346	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	421	9	1	5	2.7	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
	44436596	91967	1	None	-436	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1ccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
	CHEMBL241631	91967	1	None	-436	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1ccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
	10707972	169032	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
	CHEMBL439639	169032	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
	44567588	190203	0	None	-45	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	325	3	2	4	3.6	CCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
	CHEMBL517491	190203	0	None	-45	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	325	3	2	4	3.6	CCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
	90644230	111763	0	None	-1819	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287406	111763	0	None	-1819	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	10479188	202850	0	None	-316	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL62602	202850	0	None	-316	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	44319370	107020	0	None	-1	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
	CHEMBL315564	107020	0	None	-1	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
	44380717	120323	0	None	-138	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	CHEMBL353087	120323	0	None	-138	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	56926587	68981	0	None	-2290	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	329	3	0	5	2.3	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cn1	10.1021/jm200762g
	CHEMBL1923416	68981	0	None	-2290	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	329	3	0	5	2.3	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cn1	10.1021/jm200762g
	118711253	113924	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(O)c(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	CHEMBL3325903	113924	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(O)c(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	135398737	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
	38	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
	722	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
	CHEMBL42	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
	DB00363	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
	135398737	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
	38	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
	722	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
	CHEMBL42	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
	DB00363	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
	135398737	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
	38	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
	722	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
	CHEMBL42	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
	DB00363	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
	135398737	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
	38	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
	722	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
	CHEMBL42	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
	DB00363	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
	112500030	132441	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
	CHEMBL3697607	132441	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
	135398737	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
	38	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
	722	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
	CHEMBL42	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
	DB00363	955	93	None	-83	92	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
	1353	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
	3559	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
	86	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
	CHEMBL54	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
	DB00502	1898	93	None	-74	86	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
	681	1453	72	None	-23	39	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	940	1453	72	None	-23	39	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	947	1453	72	None	-23	39	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	CHEMBL59	1453	72	None	-23	39	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	DB00988	1453	72	None	-23	39	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	135398745	2893	112	None	-26	66	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	47	2893	112	None	-26	66	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	CHEMBL715	2893	112	None	-26	66	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	DB00334	2893	112	None	-26	66	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	117772904	132393	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	5	3.0	Cc1cc(Oc2nccc(C)c2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697560	132393	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	5	3.0	Cc1cc(Oc2nccc(C)c2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	90666903	109422	0	None	-4	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	452	4	1	5	5.0	O=C1CC(CN2CCC(c3c[nH]c4cc(F)ccc34)CC2)Cc2nc(N3CCCC3)sc21	10.1039/C1MD00202C
	CHEMBL3220219	109422	0	None	-4	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	452	4	1	5	5.0	O=C1CC(CN2CCC(c3c[nH]c4cc(F)ccc34)CC2)Cc2nc(N3CCCC3)sc21	10.1039/C1MD00202C
	155552185	174037	0	None	-660	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	CHEMBL4544086	174037	0	None	-660	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	118709173	113394	0	None	-218	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	20	0	10	9.4	O=C(CCN1CCN(CCC(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318846	113394	0	None	-218	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	20	0	10	9.4	O=C(CCN1CCN(CCC(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	72545240	93100	0	None	-229	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	469	12	0	8	3.4	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443007	93100	0	None	-229	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	469	12	0	8	3.4	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	52937777	61141	0	None	-6165	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	464	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(Cl)c2C1	10.1021/jm101639t
	CHEMBL1765630	61141	0	None	-6165	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	464	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(Cl)c2C1	10.1021/jm101639t
	57395340	69271	0	None	-407	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
	CHEMBL1928124	69271	0	None	-407	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
	71734029	91026	0	None	-10964	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
	CHEMBL2397392	91026	0	None	-10964	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
	14198593	198651	1	None	4	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
	CHEMBL57988	198651	1	None	4	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
	10064053	95878	0	None	-1995	6	Rat	5.4	pKi	=	5.4	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm960189i
	CHEMBL25924	95878	0	None	-1995	6	Rat	5.4	pKi	=	5.4	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm960189i
	10546334	65216	0	None	-2187	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	358	4	2	4	4.0	c1ccc2c(N3CCN(CCc4ccc5c(c4)NCN5)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
	CHEMBL182721	65216	0	None	-2187	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	358	4	2	4	4.0	c1ccc2c(N3CCN(CCc4ccc5c(c4)NCN5)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
	57580939	92172	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425374	92172	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
	154726529	176421	1	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4467486	176421	1	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4596338	176421	1	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	15711870	12924	0	None	-1	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	CHEMBL1189332	12924	0	None	-1	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	CHEMBL538520	12924	0	None	-1	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	154704418	176563	1	None	1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4546749	176563	1	None	1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4597533	176563	1	None	1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
	44567688	192251	0	None	-8	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	295	2	1	3	3.5	CCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
	CHEMBL520573	192251	0	None	-8	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	295	2	1	3	3.5	CCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
	42625293	56219	0	None	-912	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	549	8	2	6	3.3	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
	CHEMBL1627319	56219	0	None	-912	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	549	8	2	6	3.3	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
	3036864	202731	19	None	-26	28	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1256645	202731	19	None	-26	28	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL1814790	202731	19	None	-26	28	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	CHEMBL62	202731	19	None	-26	28	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
	133	2479	52	None	-30	43	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	1723	2479	52	None	-30	43	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	28693	2479	52	None	-30	43	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	CHEMBL19215	2479	52	None	-30	43	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	DB13520	2479	52	None	-30	43	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	24847750	183179	9	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/np50094a001
	CHEMBL479587	183179	9	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/np50094a001
	5281878	1647	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
	5281881	1647	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
	948	1647	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
	968	1647	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
	CHEMBL42055	1647	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
	CHEMBL54661	1647	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
	DB00875	1647	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
	11777127	25778	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	CHEMBL135318	25778	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
	118711256	113927	0	None	-37	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1cccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
	CHEMBL3325906	113927	0	None	-37	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1cccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
	15115516	9736	0	None	-1148	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL113527	9736	0	None	-1148	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	53317511	57908	0	None	-107	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	329	3	2	4	3.2	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
	CHEMBL1672308	57908	0	None	-107	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	329	3	2	4	3.2	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
	44380816	120325	0	None	-77	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	CHEMBL353090	120325	0	None	-77	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	44448059	94791	0	None	5	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
	CHEMBL253530	94791	0	None	5	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
	137655451	158829	0	None	-288	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4094869	158829	0	None	-288	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	3033769	3256	61	None	-10232	19	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
	3299	3256	61	None	-10232	19	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
	94	3256	61	None	-10232	19	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
	CHEMBL8809	3256	61	None	-10232	19	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
	DB12518	3256	61	None	-10232	19	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
	10544858	170004	0	None	-40	4	Rat	5.4	pKi	=	5.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm981094e
	CHEMBL444269	170004	0	None	-40	4	Rat	5.4	pKi	=	5.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm981094e
	CHEMBL542181	170004	0	None	-40	4	Rat	5.4	pKi	=	5.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm981094e
	228	444	28	None	-35	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
	33	444	28	None	-35	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
	6005	444	28	None	-35	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
	CHEMBL53	444	28	None	-35	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
	DB00714	444	28	None	-35	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
	16573	177595	34	None	-18	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL464099	177595	34	None	-18	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	44320267	206189	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86576	206189	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44278297	99048	0	None	-2511	3	Rat	4.4	pKi	=	4.4	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	382	4	0	2	5.0	O=C(c1cccc(CN2CCC(c3ccc(Cl)cc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
	CHEMBL280534	99048	0	None	-2511	3	Rat	4.4	pKi	=	4.4	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	382	4	0	2	5.0	O=C(c1cccc(CN2CCC(c3ccc(Cl)cc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
	130442557	167049	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4289538	167049	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	71110287	146300	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	CHEMBL3921127	146300	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	235224	128129	29	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
	CHEMBL36654	128129	29	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
	72708127	92174	0	None	-40	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425376	92174	0	None	-40	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
	44396235	168513	1	None	-23	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	281	6	0	2	3.8	c1ccc(Cc2ccccc2OCCN2CCCC2)cc1	10.1021/jm049720x
	CHEMBL435505	168513	1	None	-23	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	281	6	0	2	3.8	c1ccc(Cc2ccccc2OCCN2CCCC2)cc1	10.1021/jm049720x
	72699718	115168	0	None	-11	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	355	3	1	4	4.5	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CCC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344465	115168	0	None	-11	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	355	3	1	4	4.5	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CCC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	135458464	81099	0	None	-1122	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	486	3	1	5	6.2	FC(F)(F)Oc1cccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c1	10.1016/j.bmcl.2006.06.034
	CHEMBL215669	81099	0	None	-1122	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	486	3	1	5	6.2	FC(F)(F)Oc1cccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c1	10.1016/j.bmcl.2006.06.034
	46231783	200510	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	357	1	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C(=O)O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL598915	200510	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	357	1	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C(=O)O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	130442473	167313	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4294397	167313	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
	86764318	132434	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	349	4	1	5	3.1	Cc1c(-c2ccc(Oc3ncccc3C3CC3)cc2)n(C)c(=O)[nH]c1=O	nan
	CHEMBL3697600	132434	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	349	4	1	5	3.1	Cc1c(-c2ccc(Oc3ncccc3C3CC3)cc2)n(C)c(=O)[nH]c1=O	nan
	117773358	132391	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	3	1	5	4.2	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697558	132391	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	3	1	5	4.2	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	23625925	93542	0	None	-18	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	368	3	1	5	3.3	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]ncc21	10.1039/C1MD00202C
	CHEMBL246484	93542	0	None	-18	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	368	3	1	5	3.3	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]ncc21	10.1039/C1MD00202C
	10436653	32762	1	None	-562	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	521	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[te]2)CC1	10.1021/jm025558r
	CHEMBL141419	32762	1	None	-562	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	521	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[te]2)CC1	10.1021/jm025558r
	147230103	180129	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2020.127563
	CHEMBL4748915	180129	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2020.127563
	53327908	61579	0	None	-3162	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	470	8	0	5	4.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccncc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771112	61579	0	None	-3162	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	470	8	0	5	4.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccncc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	3082625	194705	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL53510	194705	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
	53327665	66450	0	None	-38	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	400	4	3	7	2.4	COC(=O)[C@@H](N)CSc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.ejmech.2011.04.028
	CHEMBL1852240	66450	0	None	-38	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	400	4	3	7	2.4	COC(=O)[C@@H](N)CSc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.ejmech.2011.04.028
	CHEMBL3216759	66450	0	None	-38	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	400	4	3	7	2.4	COC(=O)[C@@H](N)CSc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.ejmech.2011.04.028
	128434	195683	8	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	227	1	3	3	2.2	NCC1c2ccccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
	CHEMBL55693	195683	8	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	227	1	3	3	2.2	NCC1c2ccccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
	10386748	104725	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
	CHEMBL310734	104725	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
	10386748	104725	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
	CHEMBL310734	104725	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
	53363199	63822	0	None	-457	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	481	12	0	9	3.2	CCOCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
	CHEMBL1803051	63822	0	None	-457	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	481	12	0	9	3.2	CCOCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
	25139477	184221	0	None	-870	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	486	10	1	2	6.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
	CHEMBL483593	184221	0	None	-870	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	486	10	1	2	6.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
	49782603	17457	0	None	-151	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	385	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
	CHEMBL1257811	17457	0	None	-151	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	385	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
	137634397	156081	0	None	-11748	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
	CHEMBL4063145	156081	0	None	-11748	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
	10802235	13227	0	None	-1	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL1191487	13227	0	None	-1	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL542593	13227	0	None	-1	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	72545238	93098	0	None	-7413	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	425	9	0	7	3.3	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443005	93098	0	None	-7413	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	425	9	0	7	3.3	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	112500028	132439	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
	CHEMBL3697605	132439	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
	56971032	69220	0	None	-114	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccccn1	10.1016/j.ejmech.2011.11.023
	CHEMBL1927094	69220	0	None	-114	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccccn1	10.1016/j.ejmech.2011.11.023
	3082625	194705	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00004a011
	CHEMBL53510	194705	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00004a011
	3082625	194705	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	CHEMBL53510	194705	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	44582675	189677	0	None	-64	15	Human	5.4	pKi	=	5.4	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL515472	189677	0	None	-64	15	Human	5.4	pKi	=	5.4	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	10786190	114706	0	None	-50	3	Rat	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	383	2	0	4	3.7	CN1CCc2cccc3c2[C@H]1Cc1cccc(OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm960189i
	CHEMBL333836	114706	0	None	-50	3	Rat	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	383	2	0	4	3.7	CN1CCc2cccc3c2[C@H]1Cc1cccc(OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm960189i
	44406003	133133	0	None	4	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
	CHEMBL370364	133133	0	None	4	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
	448537	160226	89	None	-28	25	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	CHEMBL411	160226	89	None	-28	25	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	10813037	47127	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	439	3	1	3	4.7	COc1ccc(Br)c(CC2c3c(O)ccc(Br)c3CCN2C)c1	10.1021/jm991034o
	CHEMBL154301	47127	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	439	3	1	3	4.7	COc1ccc(Br)c(CC2c3c(O)ccc(Br)c3CCN2C)c1	10.1021/jm991034o
	90644059	112003	0	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
	CHEMBL3289643	112003	0	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
	10781204	120023	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	309	3	0	3	4.4	CCCN1CCc2cccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
	CHEMBL350457	120023	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	309	3	0	3	4.4	CCCN1CCc2cccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
	76321556	106350	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3115578	106350	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3139302	106350	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	76325150	106395	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
	CHEMBL3115575	106395	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
	CHEMBL3139554	106395	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
	44415658	141547	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	527	3	1	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3sccc3-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL384916	141547	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	527	3	1	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3sccc3-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	25110706	12572	0	None	19	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	345	2	3	3	4.4	Cc1cccc(-c2c(O)c(O)cc3c2CCNCC3c2ccccc2)c1	10.1016/j.bmc.2008.09.049
	CHEMBL1186960	12572	0	None	19	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	345	2	3	3	4.4	Cc1cccc(-c2c(O)c(O)cc3c2CCNCC3c2ccccc2)c1	10.1016/j.bmc.2008.09.049
	CHEMBL484356	12572	0	None	19	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	345	2	3	3	4.4	Cc1cccc(-c2c(O)c(O)cc3c2CCNCC3c2ccccc2)c1	10.1016/j.bmc.2008.09.049
	86767096	129402	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C#N	nan
	CHEMBL3671285	129402	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C#N	nan
	2337	3232	77	None	-53	63	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
	50	3232	77	None	-53	63	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
	5002	3232	77	None	-53	63	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
	CHEMBL716	3232	77	None	-53	63	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
	DB01224	3232	77	None	-53	63	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
	44276572	96619	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL26365	96619	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	53364225	63815	0	None	-117	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	932	25	0	18	5.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCOCCOCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	CHEMBL1803027	63815	0	None	-117	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	932	25	0	18	5.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCOCCOCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	30133	67608	8	None	-6	3	Rat	6.4	pKi	=	6.4	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	253	0	3	3	2.5	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm00163a007
	CHEMBL190519	67608	8	None	-6	3	Rat	6.4	pKi	=	6.4	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	253	0	3	3	2.5	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm00163a007
	CHEMBL541862	67608	8	None	-6	3	Rat	6.4	pKi	=	6.4	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	253	0	3	3	2.5	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm00163a007
	10667966	57130	0	None	-2	4	Bovine	5.4	pKi	=	5.4	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	387	5	0	1	6.1	CCCN(CCC)C1CCC(=C(C#C[Si](C)(C)C)C#C[Si](C)(C)C)CC1	10.1021/jm991098z
	CHEMBL164736	57130	0	None	-2	4	Bovine	5.4	pKi	=	5.4	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	387	5	0	1	6.1	CCCN(CCC)C1CCC(=C(C#C[Si](C)(C)C)C#C[Si](C)(C)C)CC1	10.1021/jm991098z
	44412182	77237	0	None	-3890	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1nn(-c2ccccc2)cc1CN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2006.02.075
	CHEMBL208018	77237	0	None	-3890	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1nn(-c2ccccc2)cc1CN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2006.02.075
	122177642	121184	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
	CHEMBL3577343	121184	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
	24823921	97868	0	None	-21	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
	CHEMBL272395	97868	0	None	-21	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
	9995378	5441	0	None	-301	4	Bovine	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3ccc(-c4cnco4)c3)CC2)cc1	10.1016/s0960-894x(99)00540-5
	CHEMBL107529	5441	0	None	-301	4	Bovine	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3ccc(-c4cnco4)c3)CC2)cc1	10.1016/s0960-894x(99)00540-5
	10359539	59024	10	None	-125	4	Bovine	4.4	pKi	=	4.4	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
	CHEMBL169459	59024	10	None	-125	4	Bovine	4.4	pKi	=	4.4	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
	91899759	129419	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	342	3	1	6	3.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1C#N	nan
	CHEMBL3671300	129419	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	342	3	1	6	3.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1C#N	nan
	57580939	92172	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425374	92172	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
	1242	3586	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	935	3586	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	CHEMBL286080	3586	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	1242	3586	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.ejmech.2014.07.059
	935	3586	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.ejmech.2014.07.059
	CHEMBL286080	3586	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.ejmech.2014.07.059
	10333837	113507	0	None	-51	3	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	0	2	3.8	COc1c(C)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	CHEMBL332178	113507	0	None	-51	3	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	0	2	3.8	COc1c(C)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	25130157	103280	0	None	-5495	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	367	3	1	3	5.1	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1coc2ccccc12	10.1021/jm800532x
	CHEMBL3084515	103280	0	None	-5495	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	367	3	1	3	5.1	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1coc2ccccc12	10.1021/jm800532x
	135409492	169146	50	None	-4	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	0	1	5	3.5	Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[N+](C)([O-])CC1	10.1016/S0960-894X(96)00567-7
	CHEMBL440512	169146	50	None	-4	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	0	1	5	3.5	Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[N+](C)([O-])CC1	10.1016/S0960-894X(96)00567-7
	15467370	102291	0	None	-3630	4	Bovine	4.4	pKi	=	4.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
	CHEMBL303538	102291	0	None	-3630	4	Bovine	4.4	pKi	=	4.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
	76321556	106350	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3115578	106350	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3139302	106350	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	151086	91949	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
	CHEMBL2414991	91949	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
	3802	203000	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm960084f
	CHEMBL63329	203000	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm960084f
	3802	203000	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm00067a009
	CHEMBL63329	203000	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm00067a009
	4302960	101034	63	None	-1258	6	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	485	10	1	5	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(C(C)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
	CHEMBL294747	101034	63	None	-1258	6	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	485	10	1	5	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(C(C)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
	10247701	85854	0	None	-2398	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	4	1	3	4.1	c1ccc2c(N3CCN(CCc4ccc5[nH]cnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
	CHEMBL2298806	85854	0	None	-2398	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	4	1	3	4.1	c1ccc2c(N3CCN(CCc4ccc5[nH]cnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
	162657175	180809	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	331	2	1	3	5.1	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
	CHEMBL4756987	180809	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	331	2	1	3	5.1	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
	16007117	80007	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL212912	80007	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	44415518	80049	0	None	45	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213084	80049	0	None	45	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	44415724	80229	0	None	97	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	547	2	1	5	6.4	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cc(Cl)cc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213881	80229	0	None	97	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	547	2	1	5	6.4	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cc(Cl)cc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	11637457	73058	1	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1039/C5MD00258C
	CHEMBL201093	73058	1	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1039/C5MD00258C
	71562964	87546	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335740	87546	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	37459	743	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127305
	62	743	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127305
	CHEMBL8514	743	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127305
	16007117	80007	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212912	80007	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	15111049	13923	0	None	1412	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	317	1	2	2	3.4	Oc1cc2c(cc1Br)CCNCC2c1ccccc1	10.1021/jm00079a008
	CHEMBL1196674	13923	0	None	1412	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	317	1	2	2	3.4	Oc1cc2c(cc1Br)CCNCC2c1ccccc1	10.1021/jm00079a008
	CHEMBL557799	13923	0	None	1412	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	317	1	2	2	3.4	Oc1cc2c(cc1Br)CCNCC2c1ccccc1	10.1021/jm00079a008
	74223771	129394	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
	CHEMBL3671277	129394	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
	86764214	132430	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	4	1	5	4.6	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)(F)F	nan
	CHEMBL3697596	132430	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	4	1	5	4.6	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)(F)F	nan
	71109897	87484	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL2334893	87484	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	10.1016/j.bmc.2012.12.016
	134145434	149385	0	None	173	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	449	5	2	6	3.6	COCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3945691	149385	0	None	173	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	449	5	2	6	3.6	COCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	45379369	7490	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1	10.1021/jm901291r
	CHEMBL1087300	7490	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1	10.1021/jm901291r
	71109897	87484	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
	CHEMBL2334893	87484	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
	37459	743	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2020.115578
	62	743	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2020.115578
	CHEMBL8514	743	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2020.115578
	10518837	100445	0	None	33	2	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL290842	100445	0	None	33	2	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
	46231924	200555	0	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	370	2	1	4	4.0	CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
	CHEMBL599134	200555	0	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	370	2	1	4	4.0	CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
	5249956	73366	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL201525	73366	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2006.11.093
	5249956	73366	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1039/C5MD00258C
	CHEMBL201525	73366	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1039/C5MD00258C
	440229	87482	53	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL2334891	87482	53	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	5249956	73366	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	CHEMBL201525	73366	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	74223826	129411	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
	CHEMBL3671293	129411	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
	228	444	28	None	-35	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	33	444	28	None	-35	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	6005	444	28	None	-35	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	CHEMBL53	444	28	None	-35	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	DB00714	444	28	None	-35	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	86767083	129385	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	4	5.3	[C-]#[N+]c1c[nH]c2ccnc(Oc3ccc(-c4c(C)ncnc4C)c(C)c3)c12	nan
	CHEMBL3671268	129385	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	4	5.3	[C-]#[N+]c1c[nH]c2ccnc(Oc3ccc(-c4c(C)ncnc4C)c(C)c3)c12	nan
	44323851	206951	0	None	3	4	Rat	8.3	pKi	=	8.3	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
	CHEMBL91310	206951	0	None	3	4	Rat	8.3	pKi	=	8.3	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
	46231770	201287	0	None	213	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NS(C)(=O)=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL604135	201287	0	None	213	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NS(C)(=O)=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	74223772	129396	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3671279	129396	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	25110705	12708	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	409	2	2	3	5.8	Cc1cccc(C2CN(C)CCc3c2cc(O)c(O)c3-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2008.09.049
	CHEMBL1187785	12708	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	409	2	2	3	5.8	Cc1cccc(C2CN(C)CCc3c2cc(O)c(O)c3-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2008.09.049
	CHEMBL520821	12708	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	409	2	2	3	5.8	Cc1cccc(C2CN(C)CCc3c2cc(O)c(O)c3-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2008.09.049
	146266	100670	8	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00079a008
	CHEMBL292418	100670	8	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00079a008
	CHEMBL540857	100670	8	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00079a008
	11324141	63828	0	None	1	3	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	303	1	0	5	3.2	CN1CCN(C2=Cn3cccc3Sc3sccc32)CC1	10.1021/jm049629t
	CHEMBL180319	63828	0	None	1	3	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	303	1	0	5	3.2	CN1CCN(C2=Cn3cccc3Sc3sccc32)CC1	10.1021/jm049629t
	44386836	62992	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	342	3	0	4	3.6	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
	CHEMBL178797	62992	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	342	3	0	4	3.6	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
	1153	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	12668023	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	30026874	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	30026875	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	3341	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	6603851	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	933	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	939	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	985	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	CHEMBL1160786	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	CHEMBL1161520	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	CHEMBL588	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	DB00800	1615	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
	122205438	137375	0	None	-26	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	307	0	0	2	4.5	CN1CCc2ccccc2Cc2sc3ccccc3c2CC1	10.1039/C5MD00258C
	CHEMBL3753266	137375	0	None	-26	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	307	0	0	2	4.5	CN1CCc2ccccc2Cc2sc3ccccc3c2CC1	10.1039/C5MD00258C
	71722299	102453	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397383	102453	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040217	102453	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	127031398	138782	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	411	8	1	5	5.0	CCCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
	CHEMBL3781035	138782	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	411	8	1	5	5.0	CCCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
	14198584	198246	0	None	12	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1016/j.bmc.2009.05.079
	CHEMBL57579	198246	0	None	12	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1016/j.bmc.2009.05.079
	86763998	132448	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697614	132448	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	74223832	129425	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
	CHEMBL3671306	129425	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
	53364083	63824	0	None	-28	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	658	21	0	11	6.2	CCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	CHEMBL1803053	63824	0	None	-28	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	658	21	0	11	6.2	CCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	44339992	109157	0	None	-501	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL321492	109157	0	None	-501	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	49782841	17620	0	None	-2511	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	523	7	1	4	6.1	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccccc2s1	10.1021/jm100899z
	CHEMBL1258382	17620	0	None	-2511	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	523	7	1	4	6.1	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccccc2s1	10.1021/jm100899z
	137633454	156567	0	None	-1230	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	645	16	3	10	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
	CHEMBL4068702	156567	0	None	-1230	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	645	16	3	10	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
	71454405	78396	0	None	-30	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
	CHEMBL2111528	78396	0	None	-30	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
	44319102	206118	0	None	-16	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
	CHEMBL86060	206118	0	None	-16	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
	11631892	78082	0	None	-30902	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	4	0	6	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1	10.1021/jm060166w
	CHEMBL210283	78082	0	None	-30902	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	4	0	6	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1	10.1021/jm060166w
	151086	91949	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
	CHEMBL2414991	91949	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
	4011	82379	49	None	-64	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1016/j.bmcl.2008.09.012
	CHEMBL21731	82379	49	None	-64	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1016/j.bmcl.2008.09.012
	118717796	115166	0	None	-14	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	4	1	4	4.7	CCC(C)Cc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	CHEMBL3344462	115166	0	None	-14	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	4	1	4	4.7	CCC(C)Cc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	11349297	85851	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	372	5	2	4	2.7	O=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
	CHEMBL2298800	85851	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	372	5	2	4	2.7	O=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
	72708060	92168	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425370	92168	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	44320123	107056	0	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL315849	107056	0	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	72708060	92168	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425370	92168	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	70692801	76534	0	None	-5	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
	CHEMBL2062850	76534	0	None	-5	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
	118709751	113514	0	None	-3162	10	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
	CHEMBL3321792	113514	0	None	-3162	10	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
	156020547	178134	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	387	4	1	3	4.3	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
	CHEMBL4649012	178134	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	387	4	1	3	4.3	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
	74223830	129424	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
	CHEMBL3671305	129424	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
	9909648	205550	3	None	-134	12	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm960084f
	CHEMBL81330	205550	3	None	-134	12	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm960084f
	71463207	84045	0	None	-169	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	357	4	0	4	4.0	COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	CHEMBL2207636	84045	0	None	-169	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	357	4	0	4	4.0	COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	137640203	156938	0	None	-54	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	452	10	0	8	3.5	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1	10.1021/acs.jmedchem.6b01857
	CHEMBL4072821	156938	0	None	-54	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	452	10	0	8	3.5	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1	10.1021/acs.jmedchem.6b01857
	10917920	111419	0	None	-5128	10	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	487	6	1	6	3.8	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
	CHEMBL327527	111419	0	None	-5128	10	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	487	6	1	6	3.8	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
	45482151	197986	0	None	-831	4	Pig	5.4	pKi	=	5.4	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	451	8	1	9	1.7	COc1ccccc1N1CCN(CCNC(=O)c2cn(-c3ccc([N+](=O)[O-])cc3)nn2)CC1	10.1016/j.bmc.2009.06.041
	CHEMBL573791	197986	0	None	-831	4	Pig	5.4	pKi	=	5.4	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	451	8	1	9	1.7	COc1ccccc1N1CCN(CCNC(=O)c2cn(-c3ccc([N+](=O)[O-])cc3)nn2)CC1	10.1016/j.bmc.2009.06.041
	44403220	71897	0	None	-169	5	Pig	5.4	pKi	=	5.4	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(F)n2)CC1	10.1016/j.bmcl.2005.07.037
	CHEMBL197214	71897	0	None	-169	5	Pig	5.4	pKi	=	5.4	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(F)n2)CC1	10.1016/j.bmcl.2005.07.037
	44380921	58299	0	None	-11	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
	CHEMBL168274	58299	0	None	-11	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
	9977532	111164	1	None	-9999	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	CHEMBL326454	111164	1	None	-9999	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	71457844	84047	0	None	-2137	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	429	6	0	4	5.1	COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	CHEMBL2207638	84047	0	None	-2137	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	429	6	0	4	5.1	COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	44381117	57801	0	None	-120	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	CHEMBL167032	57801	0	None	-120	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	9909648	205550	3	None	-134	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.7b00151
	CHEMBL81330	205550	3	None	-134	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.7b00151
	161379	187191	8	None	-79	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
	CHEMBL492418	187191	8	None	-79	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
	681	1453	72	None	-97	39	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
	940	1453	72	None	-97	39	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
	947	1453	72	None	-97	39	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
	CHEMBL59	1453	72	None	-97	39	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
	DB00988	1453	72	None	-97	39	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
	10085358	110192	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
	CHEMBL323771	110192	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
	76328713	106377	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
	CHEMBL3115576	106377	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
	CHEMBL3139455	106377	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
	1816	2523	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	4205	2523	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	7241	2523	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	CHEMBL654	2523	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	DB00370	2523	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	21119297	92171	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425373	92171	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	44299940	100940	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
	CHEMBL294186	100940	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
	44415535	80121	0	None	42	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213388	80121	0	None	42	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	24900557	198364	0	None	-17	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	409	4	1	7	3.4	CNc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
	CHEMBL576756	198364	0	None	-17	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	409	4	1	7	3.4	CNc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
	135398737	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
	38	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
	722	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
	CHEMBL42	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
	DB00363	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
	135398737	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
	38	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
	722	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
	CHEMBL42	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
	DB00363	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
	135398737	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
	38	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
	722	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
	CHEMBL42	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
	DB00363	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
	44393403	65048	0	None	-416	6	Pig	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1016/j.bmcl.2004.05.052
	CHEMBL182379	65048	0	None	-416	6	Pig	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1016/j.bmcl.2004.05.052
	135398737	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
	38	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
	722	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
	CHEMBL42	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
	DB00363	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
	135398737	955	93	None	-37	92	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
	38	955	93	None	-37	92	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
	722	955	93	None	-37	92	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
	CHEMBL42	955	93	None	-37	92	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
	DB00363	955	93	None	-37	92	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
	135398737	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
	38	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
	722	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
	CHEMBL42	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
	DB00363	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
	135398737	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
	38	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
	722	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
	CHEMBL42	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
	DB00363	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
	135398737	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
	38	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
	722	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
	CHEMBL42	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
	DB00363	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
	57393628	69284	0	None	-1230	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	5.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928137	69284	0	None	-1230	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	5.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
	135398737	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
	38	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
	722	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
	CHEMBL42	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
	DB00363	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
	135398737	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
	38	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
	722	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
	CHEMBL42	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
	DB00363	955	93	None	-204	92	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
	44339984	167773	0	None	-186	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL430522	167773	0	None	-186	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	53362841	63931	0	None	-16	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
	CHEMBL1806870	63931	0	None	-16	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
	53328719	66442	0	None	-20	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	CHEMBL1852163	66442	0	None	-20	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	CHEMBL3216980	66442	0	None	-20	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
	70690651	76532	0	None	-3	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]21	10.1016/j.ejmech.2012.07.025
	CHEMBL2062848	76532	0	None	-3	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]21	10.1016/j.ejmech.2012.07.025
	44588932	12576	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	2	3	3	4.2	Oc1cc2c(c(-c3ccc(F)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	CHEMBL1186975	12576	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	2	3	3	4.2	Oc1cc2c(c(-c3ccc(F)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	CHEMBL485041	12576	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	2	3	3	4.2	Oc1cc2c(c(-c3ccc(F)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	68663	27251	23	None	-6	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
	CHEMBL136711	27251	23	None	-6	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
	2337	3232	77	None	-53	63	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
	50	3232	77	None	-53	63	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
	5002	3232	77	None	-53	63	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
	CHEMBL716	3232	77	None	-53	63	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
	DB01224	3232	77	None	-53	63	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
	1016	3720	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3720	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3720	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3720	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3720	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3720	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	44582140	182474	0	None	-10	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	7	0	4	3.3	COc1cccc(N2CCN(CCCCN3CCc4ccccc4C3=O)CC2)c1	10.1016/j.bmcl.2009.01.067
	CHEMBL478688	182474	0	None	-10	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	7	0	4	3.3	COc1cccc(N2CCN(CCCCN3CCc4ccccc4C3=O)CC2)c1	10.1016/j.bmcl.2009.01.067
	44327167	9346	0	None	-3	4	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm981094e
	CHEMBL111393	9346	0	None	-3	4	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm981094e
	CHEMBL544319	9346	0	None	-3	4	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm981094e
	10516949	47889	0	None	2	2	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1cc2c3c(c1)Oc1ccccc1CC3N(C)CC2	10.1021/jm991034o
	CHEMBL154948	47889	0	None	2	2	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1cc2c3c(c1)Oc1ccccc1CC3N(C)CC2	10.1021/jm991034o
	117774121	132421	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	384	4	1	6	3.0	Cc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C#N)n(C)c(=O)[nH]c1=O	nan
	CHEMBL3697588	132421	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	384	4	1	6	3.0	Cc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C#N)n(C)c(=O)[nH]c1=O	nan
	9945168	123639	0	None	-41	3	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	325	2	0	5	3.0	CN1CCN(C2=Cn3c(C=O)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
	CHEMBL362060	123639	0	None	-41	3	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	325	2	0	5	3.0	CN1CCN(C2=Cn3c(C=O)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
	76325150	106395	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
	CHEMBL3115575	106395	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
	CHEMBL3139554	106395	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
	135398737	955	93	None	-83	92	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
	38	955	93	None	-83	92	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
	722	955	93	None	-83	92	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
	CHEMBL42	955	93	None	-83	92	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
	DB00363	955	93	None	-83	92	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
	124618	198357	7	None	134	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	243	1	4	4	1.9	NCC1c2cc(O)ccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
	CHEMBL57672	198357	7	None	134	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	243	1	4	4	1.9	NCC1c2cc(O)ccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
	86764319	132438	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
	CHEMBL3697604	132438	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
	127047221	139905	0	None	-1	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
	CHEMBL3799593	139905	0	None	-1	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
	127046950	140020	0	None	-23	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	CHEMBL3800303	140020	0	None	-23	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	25071385	159133	0	None	-208	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4098236	159133	0	None	-208	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	681	1453	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
	940	1453	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
	947	1453	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
	CHEMBL59	1453	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
	DB00988	1453	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
	681	1453	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
	940	1453	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
	947	1453	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
	CHEMBL59	1453	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
	DB00988	1453	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
	10333842	98403	1	None	-31	8	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
	CHEMBL27559	98403	1	None	-31	8	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
	44448070	94864	0	None	3	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	10.1021/jm060959i
	CHEMBL254147	94864	0	None	3	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	10.1021/jm060959i
	25071691	111760	0	None	-2818	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287403	111760	0	None	-2818	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	72545239	93099	0	None	-426	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	499	14	0	9	3.0	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCOCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443006	93099	0	None	-426	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	499	14	0	9	3.0	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCOCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	21119297	92171	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425373	92171	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	25186021	188000	0	None	-1318	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	10.1021/jm800689g
	CHEMBL497574	188000	0	None	-1318	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	10.1021/jm800689g
	10333842	98403	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
	CHEMBL27559	98403	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
	10333842	98403	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
	CHEMBL27559	98403	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
	1530	2169	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	3827	2169	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	7206	2169	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	CHEMBL534	2169	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	DB00920	2169	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	76328713	106377	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
	CHEMBL3115576	106377	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
	CHEMBL3139455	106377	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
	71722291	102433	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397385	102433	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040059	102433	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	11712530	187866	0	None	-41686	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1021/jm800689g
	CHEMBL496531	187866	0	None	-41686	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1021/jm800689g
	135398737	955	93	None	-44	92	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
	38	955	93	None	-44	92	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
	722	955	93	None	-44	92	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
	CHEMBL42	955	93	None	-44	92	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
	DB00363	955	93	None	-44	92	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
	44415849	141388	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	509	3	1	6	5.1	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
	CHEMBL384069	141388	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	509	3	1	6	5.1	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
	86764104	132456	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697622	132456	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	74223775	129405	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	316	3	1	4	4.4	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
	CHEMBL3671288	129405	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	316	3	1	4	4.4	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
	681	1453	72	None	-23	39	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
	940	1453	72	None	-23	39	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
	947	1453	72	None	-23	39	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
	CHEMBL59	1453	72	None	-23	39	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
	DB00988	1453	72	None	-23	39	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
	137657115	159731	0	None	-173	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4105030	159731	0	None	-173	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	10831251	163149	0	None	4	2	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL41809	163149	0	None	4	2	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	44340084	9056	0	None	-2238	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	CHEMBL109912	9056	0	None	-2238	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	25131137	187523	0	None	-190	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	558	9	2	5	7.4	Nc1nc2c(s1)C[C@@H](N(CCC1CCCCC1)CC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
	CHEMBL494509	187523	0	None	-190	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	558	9	2	5	7.4	Nc1nc2c(s1)C[C@@H](N(CCC1CCCCC1)CC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
	681	1453	72	None	-97	39	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
	940	1453	72	None	-97	39	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
	947	1453	72	None	-97	39	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
	CHEMBL59	1453	72	None	-97	39	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
	DB00988	1453	72	None	-97	39	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
	70696888	76544	0	None	-8	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
	CHEMBL2062860	76544	0	None	-8	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
	44329039	208114	0	None	-56	3	Bovine	4.4	pKi	=	4.4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL98072	208114	0	None	-56	3	Bovine	4.4	pKi	=	4.4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
	14198585	100774	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL293158	100774	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
	14198585	100774	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00118a012
	CHEMBL293158	100774	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00118a012
	44320076	206403	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87910	206403	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	11282465	193094	1	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL522746	193094	1	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
	11406615	85874	0	None	-162	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	388	5	2	4	4.1	S=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
	CHEMBL2298832	85874	0	None	-162	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	388	5	2	4	4.1	S=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
	14198585	100774	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL293158	100774	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
	14198585	100774	1	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00129a006
	CHEMBL293158	100774	1	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00129a006
	44415759	141663	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	3	1	5	6.5	CC(C)(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL385590	141663	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	3	1	5	6.5	CC(C)(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	681	1453	72	None	-154	39	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	940	1453	72	None	-154	39	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	947	1453	72	None	-154	39	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	CHEMBL59	1453	72	None	-154	39	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	DB00988	1453	72	None	-154	39	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	44276551	97347	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL26965	97347	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	10333842	98403	1	None	-31	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmc.2008.08.056
	CHEMBL27559	98403	1	None	-31	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmc.2008.08.056
	10588327	13749	0	None	22	2	Rat	7.4	pKi	=	7.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL1195441	13749	0	None	22	2	Rat	7.4	pKi	=	7.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL554571	13749	0	None	22	2	Rat	7.4	pKi	=	7.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	72699903	115172	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)Cl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344469	115172	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)Cl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	122197088	132389	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	362	3	1	5	3.4	[C-]#[N+]c1c(C)ccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
	CHEMBL3697556	132389	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	362	3	1	5	3.4	[C-]#[N+]c1c(C)ccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
	71563082	87252	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2331599	87252	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	9908125	119318	0	None	-20	4	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c2c1	10.1021/jm0009989
	CHEMBL344270	119318	0	None	-20	4	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c2c1	10.1021/jm0009989
	11016418	106095	0	None	-7244	9	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	488	6	0	7	4.2	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
	CHEMBL313424	106095	0	None	-7244	9	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	488	6	0	7	4.2	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
	71456046	84046	0	None	-2951	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	389	6	0	4	4.2	COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	CHEMBL2207637	84046	0	None	-2951	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	389	6	0	4	4.2	COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	127045853	139768	0	None	-17782	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	CHEMBL3798748	139768	0	None	-17782	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	137655795	158558	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	453	7	2	7	3.0	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	CHEMBL4091933	158558	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	453	7	2	7	3.0	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	12050201	202851	0	None	-31	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	7	1	5	5.3	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
	CHEMBL62624	202851	0	None	-31	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	7	1	5	5.3	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
	44319361	205697	0	None	-7	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
	CHEMBL82527	205697	0	None	-7	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
	44264629	97337	0	None	-316	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4c3ccc3ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	CHEMBL269576	97337	0	None	-316	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4c3ccc3ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	72545011	93097	0	None	-3162	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	411	8	0	7	2.9	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443004	93097	0	None	-3162	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	411	8	0	7	2.9	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
	42606339	17899	0	None	-97	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	397	5	1	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1	10.1021/jm100835q
	CHEMBL1259241	17899	0	None	-97	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	397	5	1	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1	10.1021/jm100835q
	71734126	91025	0	None	-4466	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
	CHEMBL2397391	91025	0	None	-4466	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
	2812	4747	101	None	-32	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	CHEMBL104	4747	101	None	-32	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	127027737	137962	0	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	342	6	1	4	2.2	O=C(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
	CHEMBL3764420	137962	0	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	342	6	1	4	2.2	O=C(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
	44399174	67983	0	None	-870	4	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatumInhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatum	ChEMBL	449	6	0	5	3.0	O=C1C2C3C=CC(C3)C2C(=O)N1OCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm050246k
	CHEMBL191226	67983	0	None	-870	4	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatumInhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatum	ChEMBL	449	6	0	5	3.0	O=C1C2C3C=CC(C3)C2C(=O)N1OCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm050246k
	44282127	116543	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	309	3	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
	CHEMBL1743804	116543	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	309	3	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
	CHEMBL33644	116543	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	309	3	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
	3083157	63006	2	None	-229	2	Rat	6.3	pKi	=	6.3	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	277	2	1	2	3.7	C=CCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
	CHEMBL1788212	63006	2	None	-229	2	Rat	6.3	pKi	=	6.3	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	277	2	1	2	3.7	C=CCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
	15711852	13307	0	None	5	3	Goldfish	6.3	pKi	=	6.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	CHEMBL1192193	13307	0	None	5	3	Goldfish	6.3	pKi	=	6.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	CHEMBL543389	13307	0	None	5	3	Goldfish	6.3	pKi	=	6.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
	176	397	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	397	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	397	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	397	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	397	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	145968810	165014	0	None	-120	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
	CHEMBL4226226	165014	0	None	-120	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
	15937731	117464	6	None	5	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	211	0	1	2	2.1	CN1CCc2cc(O)c(Cl)cc2CC1	10.1016/S0960-894X(00)80155-9
	CHEMBL340006	117464	6	None	5	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	211	0	1	2	2.1	CN1CCc2cc(O)c(Cl)cc2CC1	10.1016/S0960-894X(00)80155-9
	24766199	97496	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm701045j
	CHEMBL270426	97496	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm701045j
	24766199	97496	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm9015763
	CHEMBL270426	97496	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm9015763
	44301054	196125	0	None	-218	6	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
	CHEMBL56118	196125	0	None	-218	6	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
	25139481	184816	0	None	-32	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	392	10	1	2	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCCCC1	10.1021/jm800895v
	CHEMBL485227	184816	0	None	-32	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	392	10	1	2	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCCCC1	10.1021/jm800895v
	25186569	176958	0	None	-45708	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
	CHEMBL462508	176958	0	None	-45708	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
	122177643	121185	0	None	-2884	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	632	20	3	9	5.1	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1	10.1021/jm501889t
	CHEMBL3577344	121185	0	None	-2884	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	632	20	3	9	5.1	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1	10.1021/jm501889t
	3198	205490	76	None	-31	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205490	76	None	-31	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205490	76	None	-31	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	10803661	110895	0	None	-2	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	1	1	3	3.3	CC(=O)c1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	CHEMBL326159	110895	0	None	-2	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	1	1	3	3.3	CC(=O)c1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	25141534	56205	0	None	-2238	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	460	7	3	4	3.8	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	CHEMBL1627305	56205	0	None	-2238	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	460	7	3	4	3.8	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	76314268	106407	0	None	-2630	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3115577	106407	0	None	-2630	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3139633	106407	0	None	-2630	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	1353	1898	93	None	-74	86	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
	3559	1898	93	None	-74	86	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
	86	1898	93	None	-74	86	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
	CHEMBL54	1898	93	None	-74	86	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
	DB00502	1898	93	None	-74	86	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
	10042602	66260	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1016/j.bmcl.2004.06.005
	CHEMBL184770	66260	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1016/j.bmcl.2004.06.005
	3106	48490	16	None	-87	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
	CHEMBL15564	48490	16	None	-87	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
	10042602	66260	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1007/s00044-012-0055-5
	CHEMBL184770	66260	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1007/s00044-012-0055-5
	10683943	114355	0	None	-81	3	Rat	5.3	pKi	=	5.3	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	277	1	0	2	3.6	CC(=O)c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
	CHEMBL333134	114355	0	None	-81	3	Rat	5.3	pKi	=	5.3	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	277	1	0	2	3.6	CC(=O)c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
	135398745	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
	47	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
	CHEMBL715	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
	DB00334	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
	1353	1898	93	None	-74	86	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	3559	1898	93	None	-74	86	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	86	1898	93	None	-74	86	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	CHEMBL54	1898	93	None	-74	86	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	DB00502	1898	93	None	-74	86	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	46869265	16225	0	None	-4	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2012.08.058
	CHEMBL1224527	16225	0	None	-4	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2012.08.058
	44415839	79868	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212402	79868	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	44415345	81285	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
	CHEMBL215885	81285	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
	44415517	80048	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213083	80048	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	44415345	81285	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
	CHEMBL215885	81285	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
	11186086	63343	0	None	-12	4	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	313	1	0	3	3.2	CN1CCN(C2=Cc3cc(Cl)ccc3Cn3cccc32)CC1	10.1021/jm049629t
	CHEMBL179557	63343	0	None	-12	4	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	313	1	0	3	3.2	CN1CCN(C2=Cc3cc(Cl)ccc3Cn3cccc32)CC1	10.1021/jm049629t
	45482153	198015	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	502	9	1	7	3.9	COc1ccc(-n2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
	CHEMBL574030	198015	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	502	9	1	7	3.9	COc1ccc(-n2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
	137644833	158115	0	None	-87	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4087187	158115	0	None	-87	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	44436606	91968	0	None	-1445	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
	CHEMBL241641	91968	0	None	-1445	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
	44339992	109157	0	None	-501	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL321492	109157	0	None	-501	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	9977532	111164	1	None	-9999	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	CHEMBL326454	111164	1	None	-9999	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	71734129	91032	0	None	-10964	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
	CHEMBL2397480	91032	0	None	-10964	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
	137654675	158610	0	None	-1230	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	433	7	2	7	2.9	O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
	CHEMBL4092441	158610	0	None	-1230	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	433	7	2	7	2.9	O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
	11652518	165908	0	None	-16	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4cccnc4n3)CC2)cc1	10.1021/jm060166w
	CHEMBL425064	165908	0	None	-16	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4cccnc4n3)CC2)cc1	10.1021/jm060166w
	44329090	208003	0	None	-26	3	Bovine	4.3	pKi	=	4.3	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL97436	208003	0	None	-26	3	Bovine	4.3	pKi	=	4.3	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
	134	2497	24	None	-263	68	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	1775	2497	24	None	-263	68	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	9681	2497	24	None	-263	68	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	CHEMBL1065	2497	24	None	-263	68	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	DB00247	2497	24	None	-263	68	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	14787976	196957	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
	CHEMBL56666	196957	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
	44320303	163943	0	None	2	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL420788	163943	0	None	2	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	11358377	202316	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	295	0	0	3	3.5	CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3	10.1016/j.bmc.2009.08.028
	CHEMBL610449	202316	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	295	0	0	3	3.5	CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3	10.1016/j.bmc.2009.08.028
	44415646	139753	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	635	4	1	7	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OC(F)(F)O4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	CHEMBL379862	139753	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	635	4	1	7	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OC(F)(F)O4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	10264969	48265	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
	CHEMBL155352	48265	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
	15696487	163775	1	None	9	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL420604	163775	1	None	9	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	15654858	102273	0	None	2	2	Rat	4.3	pKi	=	4.3	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3cccnc3N(C=O)c3ccccc32)CC1	10.1021/jm00067a009
	CHEMBL303435	102273	0	None	2	2	Rat	4.3	pKi	=	4.3	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3cccnc3N(C=O)c3ccccc32)CC1	10.1021/jm00067a009
	44415807	141611	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccccc1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
	CHEMBL385295	141611	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccccc1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
	15111052	12743	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	279	3	1	2	3.6	C=CCN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL1187965	12743	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	279	3	1	2	3.6	C=CCN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL534678	12743	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	279	3	1	2	3.6	C=CCN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
	156017805	177802	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	343	4	1	3	4.2	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1	10.1016/j.bmcl.2020.127305
	CHEMBL4643886	177802	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	343	4	1	3	4.2	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1	10.1016/j.bmcl.2020.127305
	21171	186952	33	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
	CHEMBL490533	186952	33	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
	46893146	61577	0	None	-3981	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	475	8	0	5	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771110	61577	0	None	-3981	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	475	8	0	5	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	53363202	63826	0	None	-26	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	961	28	0	15	8.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(C5CCCCC5)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	CHEMBL1803055	63826	0	None	-26	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	961	28	0	15	8.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(C5CCCCC5)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	122191605	123694	0	None	-23	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	426	7	2	3	4.2	Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1	10.1021/acsmedchemlett.5b00131
	CHEMBL3622097	123694	0	None	-23	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	426	7	2	3	4.2	Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1	10.1021/acsmedchemlett.5b00131
	44319370	107020	0	None	-1	4	Bovine	6.3	pKi	=	6.3	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
	CHEMBL315564	107020	0	None	-1	4	Bovine	6.3	pKi	=	6.3	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
	10264969	48265	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
	CHEMBL155352	48265	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
	137634397	156081	0	None	-11748	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
	CHEMBL4063145	156081	0	None	-11748	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
	24824062	155688	0	None	-79	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cc3ccccn3n2)CC1	10.1021/jm701375u
	CHEMBL405260	155688	0	None	-79	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cc3ccccn3n2)CC1	10.1021/jm701375u
	44372312	53755	0	None	-43	3	Bovine	5.3	pKi	=	5.3	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
	CHEMBL160396	53755	0	None	-43	3	Bovine	5.3	pKi	=	5.3	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
	11492	37475	61	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	137	2	2	2	0.9	NCCc1cccc(O)c1	10.1021/jm9800292
	59111271	37475	61	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	137	2	2	2	0.9	NCCc1cccc(O)c1	10.1021/jm9800292
	CHEMBL145584	37475	61	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	137	2	2	2	0.9	NCCc1cccc(O)c1	10.1021/jm9800292
	42606573	17814	0	None	-81	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	381	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1	10.1021/jm100835q
	CHEMBL1258999	17814	0	None	-81	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	381	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1	10.1021/jm100835q
	136043859	138880	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	430	2	1	4	5.9	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
	CHEMBL378301	138880	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	430	2	1	4	5.9	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
	10618131	28472	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	354	6	2	4	3.4	CN(C)CCCCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL137583	28472	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	354	6	2	4	3.4	CN(C)CCCCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	10518820	110373	0	None	-31	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	307	2	0	3	3.7	COc1c(C(C)=O)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	CHEMBL324372	110373	0	None	-31	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	307	2	0	3	3.7	COc1c(C(C)=O)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	12049521	203168	0	None	-13	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	427	5	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL64288	203168	0	None	-13	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	427	5	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
	117773325	132395	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	5	2.7	Cc1cc(Oc2ncccc2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697562	132395	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	5	2.7	Cc1cc(Oc2ncccc2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	44582517	181615	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.3	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL477446	181615	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.3	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
	154726792	176560	1	None	-1202	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4475406	176560	1	None	-1202	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4597530	176560	1	None	-1202	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	9841398	99491	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
	CHEMBL28338	99491	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
	9841398	99491	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL28338	99491	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	44276552	99852	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL285924	99852	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	1353	1898	93	None	-38	86	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	3559	1898	93	None	-38	86	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	86	1898	93	None	-38	86	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	CHEMBL54	1898	93	None	-38	86	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	DB00502	1898	93	None	-38	86	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	44415822	168818	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(F)cc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL437917	168818	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(F)cc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	10409038	85213	0	None	-41	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
	CHEMBL225853	85213	0	None	-41	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
	118709176	113397	0	None	-34	4	Pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1106	29	0	14	11.8	O=C(CCc1cn(CCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318849	113397	0	None	-34	4	Pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1106	29	0	14	11.8	O=C(CCc1cn(CCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	9952858	7522	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
	CHEMBL108764	7522	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
	9952858	7522	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL108764	7522	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	167715	2856	14	None	-194	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	969	2856	14	None	-194	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	CHEMBL225230	2856	14	None	-194	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	11504230	78188	0	None	-870	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
	CHEMBL210567	78188	0	None	-870	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
	10830557	31271	0	None	-4	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(F)cc4)CC3)c2c1	10.1021/jm0009989
	CHEMBL140165	31271	0	None	-4	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(F)cc4)CC3)c2c1	10.1021/jm0009989
	46905072	10145	0	None	-28	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL1159663	10145	0	None	-28	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	25131138	187525	0	None	-9549	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	480	8	2	6	5.4	CCCN(CC[C@H]1CC[C@H](NC(=O)c2cc3ccccc3o2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	CHEMBL494511	187525	0	None	-9549	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	480	8	2	6	5.4	CCCN(CC[C@H]1CC[C@H](NC(=O)c2cc3ccccc3o2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	49782602	17137	0	None	-162	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	583	6	1	3	7.4	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
	CHEMBL1256169	17137	0	None	-162	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	583	6	1	3	7.4	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
	57390117	69270	0	None	-346	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.2	CCOCCOCc1ccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
	CHEMBL1928123	69270	0	None	-346	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.2	CCOCCOCc1ccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
	70690653	76545	0	None	-32	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
	CHEMBL2062861	76545	0	None	-32	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
	45481890	198993	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	9	2	9	4.4	COc1ccccc1N1CCN(CCCn2cc(CN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL585742	198993	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	9	2	9	4.4	COc1ccccc1N1CCN(CCCn2cc(CN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	228	444	28	None	-35	24	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	33	444	28	None	-35	24	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	6005	444	28	None	-35	24	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	CHEMBL53	444	28	None	-35	24	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	DB00714	444	28	None	-35	24	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	15225750	141360	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	383	1	1	5	3.2	CC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	CHEMBL383869	141360	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	383	1	1	5	3.2	CC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	57391216	70139	0	None	-23	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	332	6	0	5	2.9	Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940416	70139	0	None	-23	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	332	6	0	5	2.9	Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	44304603	203115	0	None	-43	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
	CHEMBL64139	203115	0	None	-43	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
	42625211	56209	0	None	-81	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	450	10	3	5	3.3	CCCOc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm900095y
	CHEMBL1627309	56209	0	None	-81	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	450	10	3	5	3.3	CCCOc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm900095y
	14138285	145130	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
	CHEMBL3912178	145130	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
	5016	109142	8	None	125	2	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
	CHEMBL32145	109142	8	None	125	2	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
	CHEMBL544114	109142	8	None	125	2	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
	74223772	129396	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3671279	129396	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	86767101	129410	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	393	4	1	5	4.4	Cc1ncnc(N2CC(F)C2)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
	CHEMBL3671292	129410	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	393	4	1	5	4.4	Cc1ncnc(N2CC(F)C2)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
	6852376	91570	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
	CHEMBL1467585	91570	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
	CHEMBL24077	91570	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
	CHEMBL503958	91570	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
	15711869	13308	0	None	6	6	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	CHEMBL1192194	13308	0	None	6	6	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	CHEMBL543390	13308	0	None	6	6	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
	15937729	118136	0	None	301	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	277	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCC2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL340855	118136	0	None	301	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	277	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCC2)C1	10.1016/S0960-894X(00)80155-9
	70690500	76044	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
	CHEMBL2057455	76044	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
	44401164	69787	0	None	-19	9	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL193639	69787	0	None	-19	9	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	15115525	109663	0	None	134	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	509	4	2	8	5.0	CN1CCc2cc(Br)c(O)cc2C(c2ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc2)C1	10.1021/jm00115a012
	CHEMBL322760	109663	0	None	134	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	509	4	2	8	5.0	CN1CCc2cc(Br)c(O)cc2C(c2ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc2)C1	10.1021/jm00115a012
	134155502	151404	0	None	20	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	341	3	2	5	3.2	CCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3961827	151404	0	None	20	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	341	3	2	5	3.2	CCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	15696466	4236	0	None	208	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00114a002
	CHEMBL100572	4236	0	None	208	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00114a002
	44320050	106804	0	None	138	3	Rat	8.3	pKi	=	8.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL314459	106804	0	None	138	3	Rat	8.3	pKi	=	8.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	86764106	132407	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	4	4.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697574	132407	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	4	4.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	44356291	22703	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	269	1	3	3	2.7	C[C@@]1(N)Cc2cc(O)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm960318v
	CHEMBL132766	22703	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	269	1	3	3	2.7	C[C@@]1(N)Cc2cc(O)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm960318v
	162643108	181632	0	None	83	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	335	1	1	3	5.0	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2020.127563
	CHEMBL4776090	181632	0	None	83	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	335	1	1	3	5.0	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2020.127563
	71563083	87543	0	None	2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335737	87543	0	None	2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	10742	3590	31	None	-2	8	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00116a004
	1225	3590	31	None	-2	8	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00116a004
	CHEMBL35354	3590	31	None	-2	8	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00116a004
	5290	200010	40	None	17	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)C1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
	CHEMBL595489	200010	40	None	17	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)C1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
	46231769	201034	0	None	371	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)C4CC4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL602659	201034	0	None	371	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)C4CC4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	15937718	115207	0	None	48	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	251	2	1	2	3.2	C=CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
	CHEMBL334728	115207	0	None	48	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	251	2	1	2	3.2	C=CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
	10732044	84384	0	None	41	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114440	84384	0	None	41	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219804	84384	0	None	41	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	46231771	200957	0	None	107	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	CHEMBL602052	200957	0	None	107	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
	11727683	62019	0	None	-1	3	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	345	1	0	4	4.2	CN1CCCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	CHEMBL177455	62019	0	None	-1	3	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	345	1	0	4	4.2	CN1CCCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
	6917970	3665	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.ejmech.2016.09.036
	8370	3665	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.ejmech.2016.09.036
	CHEMBL487387	3665	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.ejmech.2016.09.036
	6917970	3665	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2009.08.028
	8370	3665	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2009.08.028
	CHEMBL487387	3665	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2009.08.028
	161665	172561	35	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL448891	172561	35	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	2389	3306	118	None	-346	68	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
	5073	3306	118	None	-346	68	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
	96	3306	118	None	-346	68	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
	CHEMBL85	3306	118	None	-346	68	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
	DB00734	3306	118	None	-346	68	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
	2726	916	68	None	-18	73	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
	621	916	68	None	-18	73	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
	83	916	68	None	-18	73	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
	CHEMBL71	916	68	None	-18	73	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
	DB00477	916	68	None	-18	73	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
	71109989	153751	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	CHEMBL3982119	153751	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
	2407	3347	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
	59227	3347	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
	941	3347	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
	CHEMBL1303	3347	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
	DB05271	3347	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
	3716121	84052	16	None	-1258	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	332	4	0	3	4.1	COc1ccccc1N1CCN(Cc2ccc3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	CHEMBL2207643	84052	16	None	-1258	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	332	4	0	3	4.1	COc1ccccc1N1CCN(Cc2ccc3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	145986441	167148	0	None	-147	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	432	7	2	4	3.7	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Br)cc1)CC2	10.1021/acsmedchemlett.8b00229
	CHEMBL4291172	167148	0	None	-147	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	432	7	2	4	3.7	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Br)cc1)CC2	10.1021/acsmedchemlett.8b00229
	71454294	84048	0	None	-1096	7	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	431	6	0	5	4.0	COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	CHEMBL2207639	84048	0	None	-1096	7	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	431	6	0	5	4.0	COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	1577	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	164512405	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	2537	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	5355	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	5501	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	643497	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	688272	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	958	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	960	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	CHEMBL196677	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	CHEMBL26	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	CHEMBL267044	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	DB00391	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	DB16021	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
	1577	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	164512405	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	2537	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	5355	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	5501	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	643497	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	688272	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	958	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	960	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	CHEMBL196677	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	CHEMBL26	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	CHEMBL267044	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	DB00391	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	DB16021	3677	110	None	-50	26	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
	10827222	6953	1	None	-457	5	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligandBinding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligand	ChEMBL	288	3	0	2	3.6	C(#Cc1cccnc1)CCN1CC=C(c2ccccc2)CC1	10.1021/jm950721m
	CHEMBL108463	6953	1	None	-457	5	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligandBinding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligand	ChEMBL	288	3	0	2	3.6	C(#Cc1cccnc1)CCN1CC=C(c2ccccc2)CC1	10.1021/jm950721m
	45481875	198096	0	None	-12	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL574595	198096	0	None	-12	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	10939222	204379	1	None	-1000	5	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	445	8	1	4	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(Br)cc2)CC1	10.1016/0960-894X(95)00011-H
	CHEMBL71960	204379	1	None	-1000	5	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	445	8	1	4	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(Br)cc2)CC1	10.1016/0960-894X(95)00011-H
	44415825	81087	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	573	4	1	5	6.8	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccccc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	CHEMBL215641	81087	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	573	4	1	5	6.8	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccccc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	44415786	80021	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	549	6	1	5	6.9	CCC(CC)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212966	80021	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	549	6	1	5	6.9	CCC(CC)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	25141538	56211	0	None	-2089	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	440	8	3	5	2.6	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm900095y
	CHEMBL1627311	56211	0	None	-2089	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	440	8	3	5	2.6	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm900095y
	154705884	176339	1	None	-15	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4469584	176339	1	None	-15	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4595726	176339	1	None	-15	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
	11522476	74494	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	311	2	0	3	3.3	COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2	10.1021/jm050846j
	CHEMBL202924	74494	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	311	2	0	3	3.3	COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2	10.1021/jm050846j
	162660874	181859	0	None	9	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
	CHEMBL4779001	181859	0	None	9	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
	86764103	132411	13	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL3697578	132411	13	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	75201899	171892	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
	CHEMBL4469983	171892	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
	44415838	139055	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL378648	139055	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	44415560	80341	0	None	8	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	4	1	6	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Oc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL214407	80341	0	None	8	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	4	1	6	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Oc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	9883454	113939	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	CHEMBL332600	113939	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	10758745	100405	0	None	18	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115373	100405	0	None	18	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL290438	100405	0	None	18	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	9883454	113939	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	CHEMBL332600	113939	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	56833378	68304	0	None	-281	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1121	39	2	14	10.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN(CCC)C5Cc6ccccc6C5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
	CHEMBL1916549	68304	0	None	-281	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1121	39	2	14	10.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN(CCC)C5Cc6ccccc6C5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
	10665598	35053	1	None	-30	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4Cl)CC3)c2c1	10.1021/jm0009989
	CHEMBL143355	35053	1	None	-30	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4Cl)CC3)c2c1	10.1021/jm0009989
	164609519	184427	0	None	-426	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2	10.1016/j.bmcl.2021.128047
	CHEMBL4846574	184427	0	None	-426	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2	10.1016/j.bmcl.2021.128047
	44454685	95024	0	None	-63	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1cccc(CN2CCN(c3ccc(Cl)cc3)CC2)c1	10.1016/j.bmcl.2007.12.026
	CHEMBL255163	95024	0	None	-63	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1cccc(CN2CCN(c3ccc(Cl)cc3)CC2)c1	10.1016/j.bmcl.2007.12.026
	44380715	58983	0	None	-269	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
	CHEMBL169222	58983	0	None	-269	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
	155569483	176175	0	None	-154	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	2	2	5	2.9	CCNc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
	CHEMBL4593728	176175	0	None	-154	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	2	2	5	2.9	CCNc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
	14787977	198859	2	None	1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
	CHEMBL58422	198859	2	None	1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
	14787976	196957	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
	CHEMBL56666	196957	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
	44405965	74984	0	None	-3	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	449	5	2	5	3.2	O=c1[nH]c2[nH]c(-c3ccccc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
	CHEMBL203362	74984	0	None	-3	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	449	5	2	5	3.2	O=c1[nH]c2[nH]c(-c3ccccc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
	135398745	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
	47	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
	CHEMBL715	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
	DB00334	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
	44320092	161863	0	None	39	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL415080	161863	0	None	39	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	57401820	70132	0	None	-6	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	364	6	0	3	4.8	Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940409	70132	0	None	-6	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	364	6	0	3	4.8	Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
	135398745	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
	47	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
	CHEMBL715	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
	DB00334	2893	112	None	-26	66	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
	10592479	100237	0	None	48	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL288846	100237	0	None	48	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	21302490	112778	32	None	-8	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	10.1021/jm401958n
	CHEMBL3233142	112778	32	None	-8	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	10.1021/jm401958n
	CHEMBL3306803	112778	32	None	-8	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	10.1021/jm401958n
	74223829	129422	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	351	3	1	5	4.5	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1Cl	nan
	CHEMBL3671303	129422	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	351	3	1	5	4.5	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1Cl	nan
	70686343	76043	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057454	76043	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	56971028	69216	0	None	-3	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	392	8	1	6	2.5	CCOc1ccccc1N1CCN(CCCN/C(=N\C#N)c2ccccn2)CC1	10.1016/j.ejmech.2011.11.023
	CHEMBL1927090	69216	0	None	-3	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	392	8	1	6	2.5	CCOc1ccccc1N1CCN(CCCN/C(=N\C#N)c2ccccn2)CC1	10.1016/j.ejmech.2011.11.023
	15711865	13143	0	None	1	2	Goldfish	7.3	pKi	=	7.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
	CHEMBL1190906	13143	0	None	1	2	Goldfish	7.3	pKi	=	7.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
	CHEMBL541838	13143	0	None	1	2	Goldfish	7.3	pKi	=	7.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
	117774289	132386	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.1	CCc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
	CHEMBL3697553	132386	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.1	CCc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
	164585473	184538	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
	CHEMBL4848380	184538	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
	44393372	66296	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	549	8	1	5	4.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3s2)CC1	10.1016/j.bmcl.2004.05.052
	CHEMBL184993	66296	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	549	8	1	5	4.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3s2)CC1	10.1016/j.bmcl.2004.05.052
	1257607	155288	2	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	433	4	0	5	4.2	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL403032	155288	2	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	433	4	0	5	4.2	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	45268293	196112	0	None	-20	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	408	4	1	7	1.4	Cn1c(N2CCOCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
	CHEMBL561123	196112	0	None	-20	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	408	4	1	7	1.4	Cn1c(N2CCOCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
	10854877	141990	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL38757	141990	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	44454711	97491	0	None	-3311	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2cccc(OCCF)c2)CC1	10.1016/j.bmcl.2007.12.026
	CHEMBL270408	97491	0	None	-3311	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2cccc(OCCF)c2)CC1	10.1016/j.bmcl.2007.12.026
	10001207	165297	0	None	-114	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	CHEMBL423440	165297	0	None	-114	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	44567597	169440	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	592	5	4	8	5.5	CN1CCc2cc(OCCOc3cc4c5c(c3)-c3c(ccc(O)c3O)C[C@H]5N(C)CC4)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
	CHEMBL442926	169440	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	592	5	4	8	5.5	CN1CCc2cc(OCCOc3cc4c5c(c3)-c3c(ccc(O)c3O)C[C@H]5N(C)CC4)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
	90644063	112008	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289648	112008	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	14198596	101616	0	None	2	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL299056	101616	0	None	2	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
	135221	145194	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
	CHEMBL3912606	145194	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
	90644063	112008	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289648	112008	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	10826687	50919	0	None	-4	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1ccc2c(c1)CC1c3c(cccc3O2)CCN1C	10.1021/jm991034o
	CHEMBL157799	50919	0	None	-4	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1ccc2c(c1)CC1c3c(cccc3O2)CCN1C	10.1021/jm991034o
	44569447	178731	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	323	2	0	4	3.4	COc1cc2c3c(c1)-c1c(cccc1OC(C)=O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.11.025
	CHEMBL468677	178731	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	323	2	0	4	3.4	COc1cc2c3c(c1)-c1c(cccc1OC(C)=O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.11.025
	1152279	30705	7	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL1395394	30705	7	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
	135398737	955	93	None	-44	92	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
	38	955	93	None	-44	92	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
	722	955	93	None	-44	92	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
	CHEMBL42	955	93	None	-44	92	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
	DB00363	955	93	None	-44	92	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
	135398737	955	93	None	-44	92	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	955	93	None	-44	92	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	955	93	None	-44	92	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	955	93	None	-44	92	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	955	93	None	-44	92	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	228	444	28	None	-30	24	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
	33	444	28	None	-30	24	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
	6005	444	28	None	-30	24	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
	CHEMBL53	444	28	None	-30	24	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
	DB00714	444	28	None	-30	24	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
	11782988	11609	0	None	-1	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL118092	11609	0	None	-1	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	14198586	201810	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
	CHEMBL60706	201810	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
	14198586	201810	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00118a012
	CHEMBL60706	201810	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00118a012
	14198586	201810	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Compound was evaluated for the binding affinity against dopamine (D1) receptorCompound was evaluated for the binding affinity against dopamine (D1) receptor	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
	CHEMBL60706	201810	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Compound was evaluated for the binding affinity against dopamine (D1) receptorCompound was evaluated for the binding affinity against dopamine (D1) receptor	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
	11782988	11609	0	None	-1	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	CHEMBL118092	11609	0	None	-1	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
	86767100	124412	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)c(F)c1F	nan
	CHEMBL3639701	124412	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)c(F)c1F	nan
	44320256	206290	0	None	5	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87172	206290	0	None	5	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	188442	87480	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3O)C[C@@H]21	10.1016/j.bmc.2012.12.016
	CHEMBL2334887	87480	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3O)C[C@@H]21	10.1016/j.bmc.2012.12.016
	15467371	100980	0	None	-912	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
	CHEMBL294458	100980	0	None	-912	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
	10831735	31725	0	None	-2511	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)cc4)CC3)cc2c1	10.1021/jm0009989
	CHEMBL140594	31725	0	None	-2511	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)cc4)CC3)cc2c1	10.1021/jm0009989
	10567430	119267	1	None	-1445	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2cc(CN3CCN(c4ccccc4)CC3)[nH]c2c1	10.1021/jm0009989
	CHEMBL343880	119267	1	None	-1445	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2cc(CN3CCN(c4ccccc4)CC3)[nH]c2c1	10.1021/jm0009989
	44340097	9408	0	None	-4365	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	CHEMBL111749	9408	0	None	-4365	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	44567595	175253	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	327	3	3	5	2.2	CN1CCc2cc(OCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
	CHEMBL457275	175253	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	327	3	3	5	2.2	CN1CCc2cc(OCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
	137645830	157828	0	None	-131	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	424	7	1	8	2.8	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2	10.1021/acs.jmedchem.7b00363
	CHEMBL4083727	157828	0	None	-131	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	424	7	1	8	2.8	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2	10.1021/acs.jmedchem.7b00363
	11615489	69414	1	None	-588	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@H]1CCn2nccc2C1	10.1021/jm101639t
	CHEMBL193337	69414	1	None	-588	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@H]1CCn2nccc2C1	10.1021/jm101639t
	14787976	196957	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00170a025
	CHEMBL56666	196957	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00170a025
	14787977	198859	2	None	-1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
	CHEMBL58422	198859	2	None	-1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
	156012880	177418	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	364	4	0	5	3.4	C#CCOc1c(OC)cc2c3c1-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4638749	177418	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	364	4	0	5	3.4	C#CCOc1c(OC)cc2c3c1-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	10809188	9243	0	None	-83	4	Rat	5.3	pKi	=	5.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
	CHEMBL110847	9243	0	None	-83	4	Rat	5.3	pKi	=	5.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
	CHEMBL540822	9243	0	None	-83	4	Rat	5.3	pKi	=	5.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
	150	2492	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	1764	2492	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	8226	2492	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	CHEMBL1201356	2492	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	DB00353	2492	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	135398737	955	93	None	-83	92	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	38	955	93	None	-83	92	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	722	955	93	None	-83	92	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	CHEMBL42	955	93	None	-83	92	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	DB00363	955	93	None	-83	92	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	44415824	81183	0	None	13	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	3	1	5	5.5	CCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL215842	81183	0	None	13	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	3	1	5	5.5	CCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	117772871	132455	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697621	132455	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	86767099	129408	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1cc(F)c(Oc2nccc3[nH]ccc23)cc1F	nan
	CHEMBL3671290	129408	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1cc(F)c(Oc2nccc3[nH]ccc23)cc1F	nan
	135398737	955	93	None	-44	92	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
	38	955	93	None	-44	92	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
	722	955	93	None	-44	92	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
	CHEMBL42	955	93	None	-44	92	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
	DB00363	955	93	None	-44	92	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
	57390118	69273	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928126	69273	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	12997400	100977	7	None	-53	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	241	3	1	2	2.3	c1ccc(N2CCN(Cc3ccc[nH]3)CC2)cc1	10.1016/s0960-894x(02)00316-5
	CHEMBL294394	100977	7	None	-53	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	241	3	1	2	2.3	c1ccc(N2CCN(Cc3ccc[nH]3)CC2)cc1	10.1016/s0960-894x(02)00316-5
	122132	202541	17	None	-87	4	Human	5.3	pKi	=	5.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm9800292
	CHEMBL611801	202541	17	None	-87	4	Human	5.3	pKi	=	5.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm9800292
	44454735	95288	0	None	-2951	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	374	8	0	5	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
	CHEMBL256492	95288	0	None	-2951	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	374	8	0	5	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
	25131136	187487	0	None	-7244	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	504	9	2	5	6.2	CCCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	CHEMBL494308	187487	0	None	-7244	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	504	9	2	5	6.2	CCCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
	49782837	17553	0	None	-44	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	472	6	0	3	6.0	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
	CHEMBL1258154	17553	0	None	-44	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	472	6	0	3	6.0	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
	137645574	157779	0	None	-5754	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	462	7	3	6	3.1	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	CHEMBL4083239	157779	0	None	-5754	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	462	7	3	6	3.1	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	72545009	93095	0	None	-109	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443002	93095	0	None	-109	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)CC1	10.1016/j.bmcl.2013.09.026
	145970938	165132	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	233	5	1	2	3.4	CCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4228054	165132	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	233	5	1	2	3.4	CCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	11698732	72716	0	None	2	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccc(Cl)cc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
	CHEMBL199876	72716	0	None	2	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccc(Cl)cc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
	44304643	203252	0	None	-8	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	8	0	5	5.1	COc1ccc(Br)cc1-c1nc(CN(C)C[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL64668	203252	0	None	-8	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	8	0	5	5.1	COc1ccc(Br)cc1-c1nc(CN(C)C[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	3168	9230	92	None	-89	22	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	CHEMBL1108	9230	92	None	-89	22	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	162665267	182158	0	None	21	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.6	CN1CCC(C2=Nc3cc(Cl)ccc3Nc3ccccc32)=CC1(C)C	10.1016/j.bmcl.2020.127563
	CHEMBL4782694	182158	0	None	21	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.6	CN1CCC(C2=Nc3cc(Cl)ccc3Nc3ccccc32)=CC1(C)C	10.1016/j.bmcl.2020.127563
	1353	1898	93	None	-38	86	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	3559	1898	93	None	-38	86	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	86	1898	93	None	-38	86	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	CHEMBL54	1898	93	None	-38	86	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	DB00502	1898	93	None	-38	86	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	117774669	132454	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.0	CCn1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)c(C)c(=O)[nH]c1=O	nan
	CHEMBL3697620	132454	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.0	CCn1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)c(C)c(=O)[nH]c1=O	nan
	71454927	84563	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	311	1	4	4	3.0	Oc1ccc([C@H]2CN[C@@H]3CCc4cc(O)c(O)cc4[C@H]3C2)cc1	10.1016/j.bmc.2012.08.058
	CHEMBL2158636	84563	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	311	1	4	4	3.0	Oc1ccc([C@H]2CN[C@@H]3CCc4cc(O)c(O)cc4[C@H]3C2)cc1	10.1016/j.bmc.2012.08.058
	CHEMBL2221040	84563	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	311	1	4	4	3.0	Oc1ccc([C@H]2CN[C@@H]3CCc4cc(O)c(O)cc4[C@H]3C2)cc1	10.1016/j.bmc.2012.08.058
	10641637	118754	0	None	-19	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)cc4)CC3)c2c1	10.1021/jm0009989
	CHEMBL342001	118754	0	None	-19	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)cc4)CC3)c2c1	10.1021/jm0009989
	118709172	113392	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	493	8	0	4	6.6	Cc1ccc(C(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318844	113392	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	493	8	0	4	6.6	Cc1ccc(C(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2014.06.079
	10336538	1612	50	None	-5495	8	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm015522j
	974	1612	50	None	-5495	8	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm015522j
	CHEMBL310843	1612	50	None	-5495	8	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm015522j
	10336538	1612	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1016/j.bmcl.2007.12.026
	974	1612	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1016/j.bmcl.2007.12.026
	CHEMBL310843	1612	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1016/j.bmcl.2007.12.026
	44436597	91771	0	None	-251	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
	CHEMBL241210	91771	0	None	-251	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
	11559581	78389	0	None	-2754	6	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	3	0	5	3.4	Clc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
	CHEMBL211135	78389	0	None	-2754	6	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	3	0	5	3.4	Clc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
	11654739	176824	0	None	-20417	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
	CHEMBL461236	176824	0	None	-20417	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
	71734031	91031	0	None	-22908	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
	CHEMBL2397479	91031	0	None	-22908	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
	10336538	1612	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm701375u
	974	1612	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm701375u
	CHEMBL310843	1612	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm701375u
	10336538	1612	50	None	-5495	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/acs.jmedchem.7b00151
	974	1612	50	None	-5495	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/acs.jmedchem.7b00151
	CHEMBL310843	1612	50	None	-5495	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/acs.jmedchem.7b00151
	44537919	198113	0	None	-28	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL574700	198113	0	None	-28	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	10811026	28516	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	9	2	3	4.3	O=CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL137636	28516	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	9	2	3	4.3	O=CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	2398	951	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	2801	951	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	701	951	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	CHEMBL415	951	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	DB01242	951	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	6852376	91570	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
	CHEMBL1467585	91570	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
	CHEMBL24077	91570	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
	CHEMBL503958	91570	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
	44415802	80178	0	None	14	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL213668	80178	0	None	14	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	44415383	81422	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	5	1	6	5.4	COc1ccc(CCC(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1Cl	10.1016/j.bmcl.2006.06.022
	CHEMBL215950	81422	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	5	1	6	5.4	COc1ccc(CCC(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1Cl	10.1016/j.bmcl.2006.06.022
	25110708	12577	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	381	2	3	3	5.2	Oc1cc2c(c(-c3ccc4ccccc4c3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	CHEMBL1186978	12577	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	381	2	3	3	5.2	Oc1cc2c(c(-c3ccc4ccccc4c3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	CHEMBL485207	12577	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	381	2	3	3	5.2	Oc1cc2c(c(-c3ccc4ccccc4c3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
	130442561	166869	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4286110	166869	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	44276405	100081	0	None	6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
	CHEMBL287513	100081	0	None	6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
	44412191	138350	0	None	-107	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1	10.1016/j.bmcl.2006.02.075
	CHEMBL377200	138350	0	None	-107	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1	10.1016/j.bmcl.2006.02.075
	11071135	207985	0	None	-2570	8	Rat	5.3	pKi	=	5.3	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	500	6	0	6	4.6	CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O	10.1021/jm020938y
	CHEMBL97333	207985	0	None	-2570	8	Rat	5.3	pKi	=	5.3	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	500	6	0	6	4.6	CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O	10.1021/jm020938y
	11661609	79664	0	None	-5623	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	414	4	0	5	3.7	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1	10.1021/jm060166w
	CHEMBL211539	79664	0	None	-5623	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	414	4	0	5	3.7	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1	10.1021/jm060166w
	44339879	172258	0	None	-186	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
	CHEMBL447476	172258	0	None	-186	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
	44327153	109183	0	None	-3	4	Rat	6.3	pKi	=	6.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm981094e
	CHEMBL321682	109183	0	None	-3	4	Rat	6.3	pKi	=	6.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm981094e
	CHEMBL558817	109183	0	None	-3	4	Rat	6.3	pKi	=	6.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm981094e
	10738274	164867	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(Br)cc(OC)c2C1Cc1ccccc1O	10.1021/jm991034o
	CHEMBL422169	164867	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(Br)cc(OC)c2C1Cc1ccccc1O	10.1021/jm991034o
	145982261	166708	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	CHEMBL4283176	166708	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	155195311	174323	0	None	-1778	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assayDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assay	ChEMBL	433	7	3	5	3.4	C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1	10.1021/acsmedchemlett.9b00660
	CHEMBL4551160	174323	0	None	-1778	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assayDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assay	ChEMBL	433	7	3	5	3.4	C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1	10.1021/acsmedchemlett.9b00660
	24949693	182280	0	None	-7244	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	10.1021/jm800176x
	CHEMBL478413	182280	0	None	-7244	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	10.1021/jm800176x
	14198593	198651	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
	CHEMBL57988	198651	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
	36791366	87475	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL2334880	87475	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	14198593	198651	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00118a012
	CHEMBL57988	198651	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00118a012
	44405985	169536	0	None	-8	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccccc3Cl)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
	CHEMBL443567	169536	0	None	-8	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccccc3Cl)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
	122132	202541	17	None	4	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm00160a018
	CHEMBL611801	202541	17	None	4	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm00160a018
	11720302	166234	0	None	-301	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	503	7	1	3	5.2	O=C(NCCCCN1CCN(c2cccc(F)c2F)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
	CHEMBL426863	166234	0	None	-301	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	503	7	1	3	5.2	O=C(NCCCCN1CCN(c2cccc(F)c2F)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
	10939167	9468	0	None	-165	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm101639t
	CHEMBL112065	9468	0	None	-165	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm101639t
	CHEMBL129483	9468	0	None	-165	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm101639t
	44454710	155642	0	None	-478	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	378	7	0	4	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
	CHEMBL404888	155642	0	None	-478	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	378	7	0	4	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
	137631036	161127	0	None	-28	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	420	6	1	5	2.6	O=C(NCCCCN1CC[N+]2(CCOc3ccccc32)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
	CHEMBL4060837	161127	0	None	-28	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	420	6	1	5	2.6	O=C(NCCCCN1CC[N+]2(CCOc3ccccc32)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
	CHEMBL4117325	161127	0	None	-28	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	420	6	1	5	2.6	O=C(NCCCCN1CC[N+]2(CCOc3ccccc32)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
	44415623	138229	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	599	4	1	7	6.4	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	CHEMBL377043	138229	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	599	4	1	7	6.4	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	44316058	205514	0	None	-64	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	CHEMBL80974	205514	0	None	-64	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	10316297	124023	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
	CHEMBL363124	124023	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
	10316297	124023	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
	CHEMBL363124	124023	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
	53946796	67737	1	None	-5248	2	Rat	4.2	pKi	=	4.2	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
	CHEMBL1907969	67737	1	None	-5248	2	Rat	4.2	pKi	=	4.2	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
	44427970	152586	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	325	2	0	3	3.7	COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
	CHEMBL397207	152586	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	325	2	0	3	3.7	COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
	156010592	177104	0	None	14	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	376	4	1	4	3.4	C#CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4633772	177104	0	None	14	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	376	4	1	4	3.4	C#CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	86764321	132446	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	399	5	1	5	4.3	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C1CC1	nan
	CHEMBL3697612	132446	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	399	5	1	5	4.3	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C1CC1	nan
	117773598	132449	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.7	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2C)c(C)c(=O)[nH]c1=O	nan
	CHEMBL3697615	132449	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.7	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2C)c(C)c(=O)[nH]c1=O	nan
	164626655	186569	0	None	-16	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2	10.1016/j.bmcl.2021.128047
	CHEMBL4878587	186569	0	None	-16	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2	10.1016/j.bmcl.2021.128047
	44287454	13196	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL1191276	13196	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL542351	13196	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	1353	1898	93	None	-74	86	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
	3559	1898	93	None	-74	86	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
	86	1898	93	None	-74	86	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
	CHEMBL54	1898	93	None	-74	86	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
	DB00502	1898	93	None	-74	86	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
	2389	3306	118	None	-489	68	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
	5073	3306	118	None	-489	68	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
	96	3306	118	None	-489	68	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
	CHEMBL85	3306	118	None	-489	68	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
	DB00734	3306	118	None	-489	68	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
	54580906	61575	0	None	-2754	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	459	8	0	5	4.6	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771109	61575	0	None	-2754	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	459	8	0	5	4.6	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	57391895	69272	0	None	-301	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928125	69272	0	None	-301	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	3156990	8098	22	None	-28	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
	CHEMBL109173	8098	22	None	-28	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
	25139478	184932	0	None	-446	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	510	10	0	4	7.5	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
	CHEMBL485384	184932	0	None	-446	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	510	10	0	4	7.5	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
	15467369	100901	0	None	-6165	3	Bovine	4.2	pKi	=	4.2	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccccc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
	CHEMBL293956	100901	0	None	-6165	3	Bovine	4.2	pKi	=	4.2	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccccc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
	136043854	80158	0	None	-20	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	460	2	1	6	5.1	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc4c(c3)OCCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
	CHEMBL213577	80158	0	None	-20	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	460	2	1	6	5.1	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc4c(c3)OCCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
	77974401	113933	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	252	1	1	2	2.9	CN1CCc2ccc(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	CHEMBL3325920	113933	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	252	1	1	2	2.9	CN1CCc2ccc(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	154727843	176409	1	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	CHEMBL4448853	176409	1	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	CHEMBL4596221	176409	1	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	71086428	151529	0	None	-66	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL3963122	151529	0	None	-66	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	3108374	91948	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
	CHEMBL2414990	91948	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
	107715	200922	22	None	-144	20	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL1255837	200922	22	None	-144	20	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL601773	200922	22	None	-144	20	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	57401819	70131	0	None	-75	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	346	6	0	2	4.6	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940408	70131	0	None	-75	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	346	6	0	2	4.6	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
	23364995	113393	0	None	-13	4	Pig	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	417	7	0	4	5.0	CC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318845	113393	0	None	-13	4	Pig	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	417	7	0	4	5.0	CC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	86764104	132456	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697622	132456	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	156020558	178022	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	1	2	3	3.5	CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
	CHEMBL4647167	178022	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	1	2	3	3.5	CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
	44436617	91531	0	None	-20	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	481	9	1	4	4.8	COc1ccccc1N1CCN(CCCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
	CHEMBL240584	91531	0	None	-20	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	481	9	1	4	4.8	COc1ccccc1N1CCN(CCCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
	49782604	17491	0	None	-19	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	379	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
	CHEMBL1257927	17491	0	None	-19	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	379	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
	49782836	17520	0	None	-58	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	456	6	0	3	5.5	O=C(CCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
	CHEMBL1258036	17520	0	None	-58	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	456	6	0	3	5.5	O=C(CCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
	24841480	183875	0	None	-2951	20	Human	5.2	pKi	=	5.2	Binding	Antagonist activity at dopamine D1 receptor (unknown origin) by PDSP assayAntagonist activity at dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL481153	183875	0	None	-2951	20	Human	5.2	pKi	=	5.2	Binding	Antagonist activity at dopamine D1 receptor (unknown origin) by PDSP assayAntagonist activity at dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	44436603	145191	0	None	-269	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
	CHEMBL391257	145191	0	None	-269	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
	11655570	79697	0	None	-11220	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	462	4	0	5	3.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1	10.1021/jm060166w
	CHEMBL211590	79697	0	None	-11220	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	462	4	0	5	3.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1	10.1021/jm060166w
	45267409	196138	0	None	-1513	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)ncn23)CC1	10.1016/j.bmc.2009.05.015
	CHEMBL561262	196138	0	None	-1513	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)ncn23)CC1	10.1016/j.bmc.2009.05.015
	71212556	143537	0	None	-120	6	Human	6.2	pKi	=	6.2	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
	CHEMBL3899169	143537	0	None	-120	6	Human	6.2	pKi	=	6.2	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
	8447	188925	84	None	-8	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
	CHEMBL508112	188925	84	None	-8	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
	3191	102831	97	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	CHEMBL305660	102831	97	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	145969934	165021	0	None	-54	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	261	7	1	2	4.2	CCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4226336	165021	0	None	-54	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	261	7	1	2	4.2	CCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	14198573	198060	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	1	2	3.6	COc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
	CHEMBL574340	198060	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	1	2	3.6	COc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
	130424	204322	14	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	327	1	1	3	4.4	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2cccc3ccoc23)C1	10.1021/jm00170a025
	CHEMBL71600	204322	14	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	327	1	1	3	4.4	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2cccc3ccoc23)C1	10.1021/jm00170a025
	44415827	81030	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
	CHEMBL215414	81030	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
	11619691	155032	0	None	138	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	467	3	1	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(O)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	CHEMBL401690	155032	0	None	138	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	467	3	1	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(O)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
	5311428	100079	9	None	32	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL1744078	100079	9	None	32	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
	CHEMBL287504	100079	9	None	32	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
	56589560	70568	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
	CHEMBL1949725	70568	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
	1353	1898	93	None	-38	86	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
	3559	1898	93	None	-38	86	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
	86	1898	93	None	-38	86	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
	CHEMBL54	1898	93	None	-38	86	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
	DB00502	1898	93	None	-38	86	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
	6603820	95745	19	None	-4	13	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.ejmech.2011.11.039
	CHEMBL25856	95745	19	None	-4	13	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.ejmech.2011.11.039
	440229	87482	53	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
	CHEMBL2334891	87482	53	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
	6917970	3665	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	8370	3665	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	CHEMBL487387	3665	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	3246443	37656	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL1457510	37656	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	9869262	104834	0	None	-1	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	CHEMBL310997	104834	0	None	-1	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	3246443	37656	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
	CHEMBL1457510	37656	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
	10709445	101336	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115377	101336	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL296993	101336	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	10107367	102407	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL303993	102407	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	71261649	87483	9	None	15	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL2334892	87483	9	None	15	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	10640108	84382	0	None	208	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114441	84382	0	None	208	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219802	84382	0	None	208	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	10107367	102407	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
	CHEMBL303993	102407	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
	14198585	100774	1	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL293158	100774	1	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
	10107367	102407	1	None	7	4	Human	8.2	pKi	=	8.2	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
	CHEMBL303993	102407	1	None	7	4	Human	8.2	pKi	=	8.2	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
	127031399	138717	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	2	6	2.8	COc1cc2c(cc1O)C1Cc3ccc(OCCCO)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
	CHEMBL3780268	138717	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	2	6	2.8	COc1cc2c(cc1O)C1Cc3ccc(OCCCO)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
	71109797	145871	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
	CHEMBL3917753	145871	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
	71109797	145871	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
	CHEMBL3917753	145871	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
	130442514	166508	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4279267	166508	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
	25110709	12574	0	None	17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	373	2	2	3	5.0	Cc1cccc(-c2c(O)c(O)cc3c2CCN(C)CC3c2cccc(C)c2)c1	10.1016/j.bmc.2008.09.049
	CHEMBL1186967	12574	0	None	17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	373	2	2	3	5.0	Cc1cccc(-c2c(O)c(O)cc3c2CCN(C)CC3c2cccc(C)c2)c1	10.1016/j.bmc.2008.09.049
	CHEMBL484538	12574	0	None	17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	373	2	2	3	5.0	Cc1cccc(-c2c(O)c(O)cc3c2CCN(C)CC3c2cccc(C)c2)c1	10.1016/j.bmc.2008.09.049
	86764103	132411	13	None	-	1	Human	8.2	pKi	=	8.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697578	132411	13	None	-	1	Human	8.2	pKi	=	8.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	44415600	79756	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	461	4	1	6	4.8	COc1ccccc1CNN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	CHEMBL211910	79756	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	461	4	1	6	4.8	COc1ccccc1CNN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	122205437	137286	0	None	-19	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2sccc2CC1	10.1039/C5MD00258C
	CHEMBL3752512	137286	0	None	-19	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2sccc2CC1	10.1039/C5MD00258C
	12313091	86449	6	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1ccc2c(c1O)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL2314732	86449	6	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1ccc2c(c1O)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	11023546	78449	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	CHEMBL2111783	78449	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	11023546	78449	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	CHEMBL2111783	78449	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	10071501	9847	0	None	10	2	Rat	7.2	pKi	=	7.2	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	CHEMBL114228	9847	0	None	10	2	Rat	7.2	pKi	=	7.2	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	44393415	65200	0	None	-251	5	Pig	6.2	pKi	=	6.2	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	499	8	1	5	3.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1	10.1016/j.bmcl.2004.05.052
	CHEMBL182652	65200	0	None	-251	5	Pig	6.2	pKi	=	6.2	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	499	8	1	5	3.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1	10.1016/j.bmcl.2004.05.052
	137638973	156850	0	None	-1479	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccc2c(/C=N/O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4071868	156850	0	None	-1479	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccc2c(/C=N/O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	56837419	69275	0	None	-2630	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	997	35	2	14	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928128	69275	0	None	-2630	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	997	35	2	14	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	46917563	68306	0	None	-8511	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	561	18	1	7	5.5	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)C3Cc4ccccc4C3)cc2OC)nn1	10.1021/jm2009919
	CHEMBL1916551	68306	0	None	-8511	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	561	18	1	7	5.5	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)C3Cc4ccccc4C3)cc2OC)nn1	10.1021/jm2009919
	2780	110502	36	None	-138	11	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00678-4
	CHEMBL325109	110502	36	None	-138	11	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00678-4
	137634153	156408	0	None	-54	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	236	1	2	5	0.6	Oc1ccc(N2CCNCC2)c2c1OCCO2	10.1016/j.bmc.2017.08.037
	CHEMBL4066916	156408	0	None	-54	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	236	1	2	5	0.6	Oc1ccc(N2CCNCC2)c2c1OCCO2	10.1016/j.bmc.2017.08.037
	10775901	35749	1	None	-70	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cc(C)cc(C)c2)C1	10.1021/jm9708700
	CHEMBL144114	35749	1	None	-70	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cc(C)cc(C)c2)C1	10.1021/jm9708700
	10609576	118726	0	None	-42	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cccc(C)c2C)C1	10.1021/jm9708700
	CHEMBL341825	118726	0	None	-42	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cccc(C)c2C)C1	10.1021/jm9708700
	72545008	93094	0	None	-89	5	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	451	15	0	9	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443001	93094	0	None	-89	5	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	451	15	0	9	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
	15654859	203009	0	None	4	2	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3N(C)c3ccccc32)CC1	10.1021/jm00067a009
	CHEMBL63390	203009	0	None	4	2	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3N(C)c3ccccc32)CC1	10.1021/jm00067a009
	13994412	11132	1	None	-117	3	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
	CHEMBL117841	11132	1	None	-117	3	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
	10689791	164857	0	None	12	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	4	2	3	3.3	NCCCC(=O)N1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL422086	164857	0	None	12	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	4	2	3	3.3	NCCCC(=O)N1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	490	191	8	None	-60255	12	Rat	5.2	pKi	=	5.2	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
	9890547	191	8	None	-60255	12	Rat	5.2	pKi	=	5.2	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
	CHEMBL268758	191	8	None	-60255	12	Rat	5.2	pKi	=	5.2	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
	10015045	13620	1	None	-6	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm9015763
	CHEMBL119455	13620	1	None	-6	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm9015763
	9992499	73357	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
	CHEMBL201483	73357	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
	72699816	115161	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	329	3	1	4	4.1	CCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	CHEMBL3344457	115161	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	329	3	1	4	4.1	CCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	145966311	164009	0	None	-3388	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cells	ChEMBL	378	5	1	4	2.9	O=C(NCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccccn1	10.1016/j.bmc.2017.09.018
	CHEMBL4208744	164009	0	None	-3388	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cells	ChEMBL	378	5	1	4	2.9	O=C(NCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccccn1	10.1016/j.bmc.2017.09.018
	57402366	69286	0	None	-1230	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1033	32	2	17	5.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928139	69286	0	None	-1230	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1033	32	2	17	5.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
	44340333	9630	0	None	-1071	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL112833	9630	0	None	-1071	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
	44340227	110614	0	None	-2137	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL325772	110614	0	None	-2137	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
	10265732	94820	0	None	2	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
	CHEMBL253738	94820	0	None	2	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
	2477	742	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	36	742	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	437	742	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	CHEMBL49	742	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	DB00490	742	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	15508242	165225	0	None	-64	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
	CHEMBL422959	165225	0	None	-64	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
	838674	107398	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
	CHEMBL318111	107398	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
	CHEMBL542493	107398	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
	44316331	205476	0	None	-41	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	CHEMBL80686	205476	0	None	-41	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	10378389	203222	1	None	-14454	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
	CHEMBL134807	203222	1	None	-14454	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
	CHEMBL64553	203222	1	None	-14454	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
	838674	107398	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
	CHEMBL318111	107398	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
	CHEMBL542493	107398	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
	71817345	91950	0	None	-158	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
	CHEMBL2414992	91950	0	None	-158	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
	44415567	80006	0	None	58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212905	80006	0	None	58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	44415579	79816	0	None	61	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	542	4	2	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3NC3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL212186	79816	0	None	61	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	542	4	2	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3NC3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	72699817	115162	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	CHEMBL3344458	115162	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	46931072	202022	1	None	-8	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL608530	202022	1	None	-8	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	2389	3306	118	None	-489	68	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
	5073	3306	118	None	-489	68	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
	96	3306	118	None	-489	68	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
	CHEMBL85	3306	118	None	-489	68	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
	DB00734	3306	118	None	-489	68	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
	122189391	123220	0	None	-72	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	431	7	0	9	2.1	COc1ccccc1N1CCN(CCc2cn(-c3ccn4ncc(C=O)c4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
	CHEMBL3613877	123220	0	None	-72	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	431	7	0	9	2.1	COc1ccccc1N1CCN(CCc2cn(-c3ccn4ncc(C=O)c4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
	44264742	97145	0	None	-13	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	298	3	0	4	2.8	c1ccn2ncc(CN3CCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(98)00692-1
	CHEMBL268190	97145	0	None	-13	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	298	3	0	4	2.8	c1ccn2ncc(CN3CCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(98)00692-1
	2	3237	23	None	-977	29	Human	7.2	pKi	=	7.2	Binding	Binding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cellsBinding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0503805
	54562	3237	23	None	-977	29	Human	7.2	pKi	=	7.2	Binding	Binding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cellsBinding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0503805
	CHEMBL240773	3237	23	None	-977	29	Human	7.2	pKi	=	7.2	Binding	Binding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cellsBinding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0503805
	11023546	78449	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	CHEMBL2111783	78449	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	9839050	112352	0	None	-131	9	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
	CHEMBL329566	112352	0	None	-131	9	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
	117773522	132418	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	6	3.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697585	132418	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	6	3.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	24863698	176674	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	253	0	2	2	2.7	Oc1ccc2c(c1)CCNCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
	CHEMBL459871	176674	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	253	0	2	2	2.7	Oc1ccc2c(c1)CCNCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
	11023546	78449	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	CHEMBL2111783	78449	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	3108374	91948	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
	CHEMBL2414990	91948	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
	44400626	70373	0	None	-999	5	Pig	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL194555	70373	0	None	-999	5	Pig	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	44403214	72464	0	None	-446	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)nc2)CC1	10.1016/j.bmcl.2005.07.037
	CHEMBL198993	72464	0	None	-446	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)nc2)CC1	10.1016/j.bmcl.2005.07.037
	44448063	155221	0	None	3	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
	CHEMBL402736	155221	0	None	3	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
	154727713	176340	1	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	426	10	1	6	4.5	COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4514586	176340	1	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	426	10	1	6	4.5	COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4595727	176340	1	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	426	10	1	6	4.5	COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	118717797	115167	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	2	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344463	115167	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	2	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	10758760	22469	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	329	4	1	2	4.8	CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL132545	22469	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	329	4	1	2	4.8	CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	161379	187191	8	None	-79	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
	CHEMBL492418	187191	8	None	-79	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
	154703438	176357	1	None	-26	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	496	12	0	6	6.1	COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
	CHEMBL4475699	176357	1	None	-26	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	496	12	0	6	6.1	COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
	CHEMBL4595859	176357	1	None	-26	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	496	12	0	6	6.1	COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
	136043857	79757	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	5.0	Clc1ccc2c(c1)N=C(N1CCN(Cc3cccc4c3OCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
	CHEMBL211915	79757	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	5.0	Clc1ccc2c(c1)N=C(N1CCN(Cc3cccc4c3OCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
	44281881	99821	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
	CHEMBL1743774	99821	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
	CHEMBL285717	99821	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
	1242	3586	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	935	3586	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	CHEMBL286080	3586	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	44415743	80079	0	None	30	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL213201	80079	0	None	30	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	6852376	91570	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
	CHEMBL1467585	91570	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
	CHEMBL24077	91570	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
	CHEMBL503958	91570	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
	6852376	91570	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL1467585	91570	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL24077	91570	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL503958	91570	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	1242	3586	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	935	3586	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	CHEMBL286080	3586	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	70684206	76036	0	None	11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
	CHEMBL2057442	76036	0	None	11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
	70692653	76037	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	CHEMBL2057443	76037	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	70692652	76035	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
	CHEMBL2057441	76035	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
	54580905	61573	0	None	-2570	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771107	61573	0	None	-2570	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	56594533	70569	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
	CHEMBL1949726	70569	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
	56837634	69277	0	None	-1479	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1041	38	2	15	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928130	69277	0	None	-1479	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1041	38	2	15	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	9796958	146553	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115374	146553	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL39230	146553	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL544814	146553	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	11633170	78383	0	None	-2818	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	421	5	0	7	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1	10.1021/jm060166w
	CHEMBL211118	78383	0	None	-2818	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	421	5	0	7	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1	10.1021/jm060166w
	11583188	139257	0	None	-19498	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	448	4	0	5	3.3	COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1	10.1021/jm060166w
	CHEMBL379125	139257	0	None	-19498	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	448	4	0	5	3.3	COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1	10.1021/jm060166w
	10355510	155638	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
	CHEMBL404865	155638	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
	71461481	84041	0	None	-676	5	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	356	4	0	3	4.1	C#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
	CHEMBL2207632	84041	0	None	-676	5	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	356	4	0	3	4.1	C#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
	71450707	84049	0	None	-1698	7	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	444	6	0	5	3.9	COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	CHEMBL2207640	84049	0	None	-1698	7	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	444	6	0	5	3.9	COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	25131135	187524	0	None	-8511	3	Rat	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	448	6	3	5	4.7	Nc1nc2c(s1)C[C@@H](NCC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
	CHEMBL494510	187524	0	None	-8511	3	Rat	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	448	6	3	5	4.7	Nc1nc2c(s1)C[C@@H](NCC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
	90644058	112002	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
	CHEMBL3289642	112002	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
	90644058	112002	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
	CHEMBL3289642	112002	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
	130907	194660	5	None	-3311	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm701045j
	CHEMBL53294	194660	5	None	-3311	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm701045j
	64143	198841	62	None	-1	8	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
	CHEMBL584	198841	62	None	-1	8	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
	154725277	176408	1	None	-25	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4472900	176408	1	None	-25	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4596220	176408	1	None	-25	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
	10015860	99249	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL281932	99249	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	44415598	77989	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccc(S(=O)(=O)N2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
	CHEMBL209805	77989	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccc(S(=O)(=O)N2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
	44415612	138930	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	6	6.0	CCOc1ccc2ccccc2c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	CHEMBL378512	138930	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	6	6.0	CCOc1ccc2ccccc2c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
	134149077	148299	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	4	2	5	3.9	CCC(C)Oc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3936976	148299	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	4	2	5	3.9	CCC(C)Oc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	681	1453	72	None	-23	39	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	940	1453	72	None	-23	39	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	947	1453	72	None	-23	39	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	CHEMBL59	1453	72	None	-23	39	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	DB00988	1453	72	None	-23	39	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	228	444	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	33	444	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	6005	444	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	CHEMBL53	444	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	DB00714	444	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
	117774495	132398	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	396	4	1	6	2.7	Cc1cc(Oc2ncccc2N2CC(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697565	132398	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	396	4	1	6	2.7	Cc1cc(Oc2ncccc2N2CC(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	40152769	201785	2	None	-107	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL606939	201785	2	None	-107	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
	45481888	198991	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL585740	198991	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	21171	186952	33	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL490533	186952	33	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	135515431	4216	34	None	-10	3	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	1	2	6	2.6	CN1CCN(C2=Nc3ccccc3Nc3sc(CO)cc32)CC1	10.1016/S0960-894X(96)00567-7
	CHEMBL100454	4216	34	None	-10	3	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	1	2	6	2.6	CN1CCN(C2=Nc3ccccc3Nc3sc(CO)cc32)CC1	10.1016/S0960-894X(96)00567-7
	72699818	115169	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	341	3	1	4	4.1	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344466	115169	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	341	3	1	4	4.1	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	11504230	78188	0	None	-870	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
	CHEMBL210567	78188	0	None	-870	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
	228	444	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
	33	444	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
	6005	444	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
	CHEMBL53	444	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
	DB00714	444	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
	44448061	94818	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
	CHEMBL253736	94818	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
	45270813	196666	0	None	-776	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)nc(C)n34)CC2)cc1	10.1016/j.bmc.2009.05.015
	CHEMBL564709	196666	0	None	-776	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)nc(C)n34)CC2)cc1	10.1016/j.bmc.2009.05.015
	71457956	78395	0	None	-87	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL2111527	78395	0	None	-87	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	76325152	106344	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
	CHEMBL3115579	106344	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
	CHEMBL3139262	106344	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
	10037962	206684	0	None	-51	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1ABinding affinity against dopamine receptor D1A	ChEMBL	254	0	1	2	3.4	c1cc2c3c(c1)c1c(n3CCNC2)CCCCCC1	10.1016/j.bmcl.2004.02.100
	CHEMBL89738	206684	0	None	-51	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1ABinding affinity against dopamine receptor D1A	ChEMBL	254	0	1	2	3.4	c1cc2c3c(c1)c1c(n3CCNC2)CCCCCC1	10.1016/j.bmcl.2004.02.100
	118711254	113925	0	None	-147	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	358	4	2	3	4.6	CN1CCc2cc(NCc3ccccc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	CHEMBL3325904	113925	0	None	-147	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	358	4	2	3	4.6	CN1CCc2cc(NCc3ccccc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
	42626315	56220	0	None	-1445	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	439	8	2	6	3.2	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	CHEMBL1627320	56220	0	None	-1445	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	439	8	2	6	3.2	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	10363751	163056	0	None	-1584	3	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	402	6	0	4	3.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(F)cc2)C1	10.1016/s0960-894x(99)00201-2
	CHEMBL417661	163056	0	None	-1584	3	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	402	6	0	4	3.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(F)cc2)C1	10.1016/s0960-894x(99)00201-2
	45269974	13590	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	371	3	2	3	5.3	CCCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL1194307	13590	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	371	3	2	3	5.3	CCCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL550792	13590	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	371	3	2	3	5.3	CCCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	91899756	129413	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cc(=O)[nH]nc1C	nan
	CHEMBL3671295	129413	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cc(=O)[nH]nc1C	nan
	9888555	165580	16	None	-3235	8	Human	6.2	pKi	=	6.2	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm025558r
	CHEMBL424294	165580	16	None	-3235	8	Human	6.2	pKi	=	6.2	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm025558r
	25071691	111760	0	None	-2818	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287403	111760	0	None	-2818	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	6469918	79862	13	None	-954	6	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
	CHEMBL212370	79862	13	None	-954	6	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
	71450812	78393	0	None	-338	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL2111525	78393	0	None	-338	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	3036864	202731	19	None	-2	28	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL1256645	202731	19	None	-2	28	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL1814790	202731	19	None	-2	28	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL62	202731	19	None	-2	28	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
	10360174	168224	1	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	344	0	0	5	3.5	CN1CCN(C2=Nc3cccnc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
	CHEMBL433744	168224	1	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	344	0	0	5	3.5	CN1CCN(C2=Nc3cccnc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
	10660476	47343	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
	CHEMBL154468	47343	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
	15654856	203001	0	None	2	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	311	0	1	5	2.6	CN1CCN(C2=Nc3cccnc3Nc3ccc(F)cc32)CC1	10.1021/jm00067a009
	CHEMBL63347	203001	0	None	2	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	311	0	1	5	2.6	CN1CCN(C2=Nc3cccnc3Nc3ccc(F)cc32)CC1	10.1021/jm00067a009
	42625207	56204	0	None	-257	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	421	7	1	5	4.0	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	CHEMBL1627304	56204	0	None	-257	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	421	7	1	5	4.0	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	44323890	206894	0	None	1	4	Rat	7.2	pKi	=	7.2	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	316	1	0	2	4.2	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
	CHEMBL90977	206894	0	None	1	4	Rat	7.2	pKi	=	7.2	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	316	1	0	2	4.2	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
	3039881	174233	10	None	4	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
	CHEMBL45491	174233	10	None	4	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
	44415638	79855	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212334	79855	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	44415490	139213	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C(F)(F)F)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL378886	139213	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C(F)(F)F)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	134150645	151621	0	None	10	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	475	7	2	5	5.5	CCCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3963862	151621	0	None	10	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	475	7	2	5	5.5	CCCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	44300069	196094	0	None	35	2	Rat	7.2	pKi	=	7.2	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
	CHEMBL56100	196094	0	None	35	2	Rat	7.2	pKi	=	7.2	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
	41532205	78248	1	None	-954	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
	CHEMBL210717	78248	1	None	-954	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
	11504230	78188	0	None	-1023	7	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm100899z
	CHEMBL210567	78188	0	None	-1023	7	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm100899z
	145990141	166755	0	None	-323	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	388	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Cl)cc1)CC2	10.1021/acsmedchemlett.8b00229
	CHEMBL4283982	166755	0	None	-323	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	388	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Cl)cc1)CC2	10.1021/acsmedchemlett.8b00229
	44454709	97490	0	None	-5248	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	404	9	0	6	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
	CHEMBL270406	97490	0	None	-5248	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	404	9	0	6	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
	12888943	9537	0	None	-812	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)CC2)cc1Cl	10.1016/s0960-894x(03)00678-4
	CHEMBL112395	9537	0	None	-812	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)CC2)cc1Cl	10.1016/s0960-894x(03)00678-4
	10660476	47343	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
	CHEMBL154468	47343	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
	25139332	184295	0	None	-7	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	352	11	1	2	5.0	CCCN(CCC)CCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
	CHEMBL484204	184295	0	None	-7	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	352	11	1	2	5.0	CCCN(CCC)CCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
	16121920	195852	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	380	5	1	6	2.7	COc1ccccc1N1CCN(Cc2c(C)[nH]c3nc(N(C)C)ncc23)CC1	10.1016/j.bmc.2009.05.015
	CHEMBL558838	195852	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	380	5	1	6	2.7	COc1ccccc1N1CCN(Cc2c(C)[nH]c3nc(N(C)C)ncc23)CC1	10.1016/j.bmc.2009.05.015
	45267435	195968	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1nccc2c(CN3CCN(c4ccccc4)CC3)c[nH]c12	10.1016/j.bmc.2009.05.015
	CHEMBL559868	195968	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1nccc2c(CN3CCN(c4ccccc4)CC3)c[nH]c12	10.1016/j.bmc.2009.05.015
	52937776	61140	0	None	-9549	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2nccc2C1	10.1021/jm101639t
	CHEMBL1765629	61140	0	None	-9549	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2nccc2C1	10.1021/jm101639t
	127046948	140045	0	None	-295	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	CHEMBL3800468	140045	0	None	-295	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	118709168	113388	0	None	-33	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1000	29	0	8	14.4	O=C(CCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318840	113388	0	None	-33	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1000	29	0	8	14.4	O=C(CCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	12050200	102063	0	None	-128	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	6	1	4	4.6	c1ccc(CN2CCC(NCc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
	CHEMBL302186	102063	0	None	-128	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	6	1	4	4.6	c1ccc(CN2CCC(NCc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
	11708363	71873	1	None	-23	4	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@@H]1CCn2nccc2C1	10.1021/jm101639t
	CHEMBL197159	71873	1	None	-23	4	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@@H]1CCn2nccc2C1	10.1021/jm101639t
	44329057	207972	0	None	-93	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL97283	207972	0	None	-93	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
	86767109	129420	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	6	3.5	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
	CHEMBL3671301	129420	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	6	3.5	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
	52940985	17554	0	None	-69	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
	CHEMBL1258155	17554	0	None	-69	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
	10666053	100358	0	None	-1	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL289927	100358	0	None	-1	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	156013324	177469	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	310	2	1	4	3.0	COc1cc2c3c(c1OC)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4639398	177469	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	310	2	1	4	3.0	COc1cc2c3c(c1OC)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	76325152	106344	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
	CHEMBL3115579	106344	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
	CHEMBL3139262	106344	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
	90140337	129388	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	4	2	6	3.1	COc1cnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c2c[nH]nc12	nan
	CHEMBL3671271	129388	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	4	2	6	3.1	COc1cnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c2c[nH]nc12	nan
	10333842	98403	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
	CHEMBL27559	98403	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
	10333842	98403	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.06.016
	CHEMBL27559	98403	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.06.016
	10333842	98403	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.11.025
	CHEMBL27559	98403	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.11.025
	681	1453	72	None	-23	39	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	940	1453	72	None	-23	39	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	947	1453	72	None	-23	39	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	CHEMBL59	1453	72	None	-23	39	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	DB00988	1453	72	None	-23	39	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
	14371639	103096	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00170a025
	CHEMBL307790	103096	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00170a025
	46231646	200442	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(N)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL598515	200442	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(N)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	14371639	103096	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00081a010
	CHEMBL307790	103096	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00081a010
	44415826	80362	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL214503	80362	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	44415705	138641	0	None	12	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	2	2	6	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL377756	138641	0	None	12	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	2	2	6	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	1218	3589	30	None	-11	8	Human	8.2	pKi	=	8.2	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/jm00116a004
	938	3589	30	None	-11	8	Human	8.2	pKi	=	8.2	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/jm00116a004
	CHEMBL353335	3589	30	None	-11	8	Human	8.2	pKi	=	8.2	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/jm00116a004
	11306892	201283	0	None	79	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)Nc4c(Cl)cccc4Cl)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	CHEMBL604129	201283	0	None	79	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)Nc4c(Cl)cccc4Cl)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
	15069446	198688	0	None	213	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	293	0	1	2	3.6	Cc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
	CHEMBL58205	198688	0	None	213	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	293	0	1	2	3.6	Cc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
	44415594	80230	0	None	177	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213882	80230	0	None	177	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	135398737	955	93	None	-44	92	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
	38	955	93	None	-44	92	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
	722	955	93	None	-44	92	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
	CHEMBL42	955	93	None	-44	92	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
	DB00363	955	93	None	-44	92	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
	71109804	87477	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	10.1016/j.bmc.2012.12.016
	CHEMBL2334882	87477	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	10.1016/j.bmc.2012.12.016
	71109805	87476	0	None	27	3	Human	8.1	pKi	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
	CHEMBL2334881	87476	0	None	27	3	Human	8.1	pKi	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
	15937727	116552	0	None	158	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	307	1	1	2	4.6	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCCC2)C1	10.1016/S0960-894X(00)80155-9
	CHEMBL336532	116552	0	None	158	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	307	1	1	2	4.6	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCCC2)C1	10.1016/S0960-894X(00)80155-9
	11536995	139530	1	None	3	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL379662	139530	1	None	3	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	86764210	132412	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	1	4	4.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697579	132412	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	1	4	4.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	44415552	80211	0	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
	CHEMBL213795	80211	0	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
	134157446	153762	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	371	5	2	6	2.8	COCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3982215	153762	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	371	5	2	6	2.8	COCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	9901453	128462	0	None	-2	3	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	315	1	0	4	3.3	CN1CCN(C2=Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm0309811
	CHEMBL366679	128462	0	None	-2	3	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	315	1	0	4	3.3	CN1CCN(C2=Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm0309811
	44415595	79864	0	None	27	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	3	1	6	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL212383	79864	0	None	27	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	3	1	6	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	127031423	138737	0	None	6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	369	5	1	5	3.9	CCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
	CHEMBL3780506	138737	0	None	6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	369	5	1	5	3.9	CCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
	162672733	182995	0	None	102	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	317	1	1	3	4.8	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
	CHEMBL4793813	182995	0	None	102	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	317	1	1	3	4.8	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
	44316024	205430	0	None	-2	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	249	5	2	3	2.9	CCCCN1CCCC1Cc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
	CHEMBL80369	205430	0	None	-2	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	249	5	2	3	2.9	CCCCN1CCCC1Cc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
	70690498	76038	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057445	76038	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	74223774	129399	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	5	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc2nccn12	nan
	CHEMBL3671282	129399	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	5	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc2nccn12	nan
	17756213	149680	1	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm070388+
	CHEMBL394779	149680	1	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm070388+
	135398745	2893	112	None	-26	66	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
	47	2893	112	None	-26	66	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
	CHEMBL715	2893	112	None	-26	66	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
	DB00334	2893	112	None	-26	66	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
	10540201	100201	0	None	4	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL288536	100201	0	None	4	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
	1353	1898	93	None	-74	86	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
	3559	1898	93	None	-74	86	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
	86	1898	93	None	-74	86	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
	CHEMBL54	1898	93	None	-74	86	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
	DB00502	1898	93	None	-74	86	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
	10333842	98403	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
	CHEMBL27559	98403	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
	13678336	201959	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	289	1	3	3	3.1	Oc1c(O)c(-c2ccccc2)c2c(c1Cl)CCNCC2	10.1021/jm00160a018
	CHEMBL60808	201959	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	289	1	3	3	3.1	Oc1c(O)c(-c2ccccc2)c2c(c1Cl)CCNCC2	10.1021/jm00160a018
	10610641	98891	0	None	-47	5	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
	CHEMBL27940	98891	0	None	-47	5	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
	11638780	77066	0	None	-1737	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	345	3	0	5	2.8	Fc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
	CHEMBL207488	77066	0	None	-1737	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	345	3	0	5	2.8	Fc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
	70686495	76540	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccc(Br)cc3)[C@H]21	10.1016/j.ejmech.2012.07.025
	CHEMBL2062856	76540	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccc(Br)cc3)[C@H]21	10.1016/j.ejmech.2012.07.025
	44372198	49110	0	None	-239	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	420	4	0	4	5.1	Fc1ccc(-c2cccc3c(CN4CCN(c5ccc(Cl)cc5)CC4)cnn23)cc1	10.1016/s0960-894x(01)00814-9
	CHEMBL156198	49110	0	None	-239	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	420	4	0	4	5.1	Fc1ccc(-c2cccc3c(CN4CCN(c5ccc(Cl)cc5)CC4)cnn23)cc1	10.1016/s0960-894x(01)00814-9
	44270444	49294	0	None	-138	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
	CHEMBL156369	49294	0	None	-138	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
	11078813	111991	0	None	-19	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	356	4	1	5	2.8	OCc1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
	CHEMBL328925	111991	0	None	-19	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	356	4	1	5	2.8	OCc1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
	12928483	13315	0	None	6	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	239	1	2	2	2.7	Oc1ccc2c(c1)C(c1ccccc1)CNCC2	10.1021/jm00079a008
	CHEMBL1192258	13315	0	None	6	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	239	1	2	2	2.7	Oc1ccc2c(c1)C(c1ccccc1)CNCC2	10.1021/jm00079a008
	CHEMBL543472	13315	0	None	6	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	239	1	2	2	2.7	Oc1ccc2c(c1)C(c1ccccc1)CNCC2	10.1021/jm00079a008
	44320116	164084	0	None	7	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL420972	164084	0	None	7	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	10810641	9360	0	None	-21	2	Rat	5.2	pKi	=	5.2	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	394	7	0	4	3.8	O=C(CCCN1CCN(CC2CC(=O)c3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm981094e
	CHEMBL111509	9360	0	None	-21	2	Rat	5.2	pKi	=	5.2	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	394	7	0	4	3.8	O=C(CCCN1CCN(CC2CC(=O)c3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm981094e
	CHEMBL544089	9360	0	None	-21	2	Rat	5.2	pKi	=	5.2	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	394	7	0	4	3.8	O=C(CCCN1CCN(CC2CC(=O)c3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm981094e
	156011233	177275	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	334	3	1	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4636589	177275	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	334	3	1	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	44415599	138426	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccccc1S(=O)(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	CHEMBL377452	138426	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccccc1S(=O)(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
	9857902	60774	0	None	-26	5	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	311	1	0	4	3.5	Cc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
	CHEMBL176169	60774	0	None	-26	5	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	311	1	0	4	3.5	Cc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
	15115512	9365	7	None	-104	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	324	6	2	3	3.8	CCCN(CCc1ccc(N)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL111532	9365	7	None	-104	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	324	6	2	3	3.8	CCCN(CCc1ccc(N)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
	25093832	155856	0	None	-2290	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4060461	155856	0	None	-2290	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	11574902	78421	0	None	-28183	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	400	4	0	5	3.4	COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1	10.1021/jm060166w
	CHEMBL211164	78421	0	None	-28183	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	400	4	0	5	3.4	COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1	10.1021/jm060166w
	44339953	109673	0	None	-707	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
	CHEMBL322802	109673	0	None	-707	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
	17469721	77996	5	None	-22	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	320	4	0	6	2.0	c1ccc(-n2cc(CN3CCN(c4ncccn4)CC3)cn2)cc1	10.1016/j.bmcl.2006.02.075
	CHEMBL209832	77996	5	None	-22	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	320	4	0	6	2.0	c1ccc(-n2cc(CN3CCN(c4ncccn4)CC3)cn2)cc1	10.1016/j.bmcl.2006.02.075
	45271691	195530	0	None	-107	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	369	3	0	5	3.6	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
	CHEMBL554692	195530	0	None	-107	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	369	3	0	5	3.6	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
	44372338	53816	0	None	-2511	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	398	4	0	4	3.9	C[Si](C)(C)c1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
	CHEMBL160454	53816	0	None	-2511	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	398	4	0	4	3.9	C[Si](C)(C)c1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
	44329099	208058	0	None	-40	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL97750	208058	0	None	-40	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
	25186023	187720	0	None	-50118	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	10.1021/jm800689g
	CHEMBL495572	187720	0	None	-50118	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	10.1021/jm800689g
	10527469	156241	3	None	-1548	16	Mouse	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligand	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
	CHEMBL40650	156241	3	None	-1548	16	Mouse	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligand	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
	10421583	99155	1	None	-9	5	Rat	6.1	pKi	=	6.1	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm960189i
	CHEMBL281357	99155	1	None	-9	5	Rat	6.1	pKi	=	6.1	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm960189i
	CHEMBL4520788	213952	10	None	-33	25	Human	6.1	pKi	=	6.1	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a DRD1	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
	72699904	115173	0	None	-60	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	377	5	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344470	115173	0	None	-60	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	377	5	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	44385715	61045	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	280	1	0	2	3.8	CN1CCc2cccc3c2c(cn3-c2ccc(F)cc2)C1	10.1016/s0960-894x(98)00138-3
	CHEMBL176476	61045	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	280	1	0	2	3.8	CN1CCc2cccc3c2c(cn3-c2ccc(F)cc2)C1	10.1016/s0960-894x(98)00138-3
	156011458	177280	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	2	2	3	3.4	COc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL4636741	177280	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	2	2	3	3.4	COc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
	228	444	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
	33	444	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
	6005	444	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
	CHEMBL53	444	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
	DB00714	444	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
	228	444	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
	33	444	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
	6005	444	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
	CHEMBL53	444	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
	DB00714	444	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
	13869641	113376	0	None	-29	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	431	8	0	4	5.4	CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318824	113376	0	None	-29	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	431	8	0	4	5.4	CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	9819674	12902	0	None	-10	5	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	CHEMBL118919	12902	0	None	-10	5	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	74223827	129416	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	335	3	1	5	4.0	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
	CHEMBL3671298	129416	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	335	3	1	5	4.0	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
	9819674	12902	0	None	-10	5	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	CHEMBL118919	12902	0	None	-10	5	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
	11208237	100947	0	None	109	2	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	279	0	1	2	3.3	CN1CCc2ccc(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
	CHEMBL294221	100947	0	None	109	2	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	279	0	1	2	3.3	CN1CCc2ccc(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
	10849018	13905	0	None	-120	3	Rat	6.1	pKi	=	6.1	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	261	1	0	1	4.1	C=Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
	CHEMBL119656	13905	0	None	-120	3	Rat	6.1	pKi	=	6.1	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	261	1	0	1	4.1	C=Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
	44400585	68626	0	None	-1949	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL191962	68626	0	None	-1949	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	10425969	100981	3	None	-1862	4	Bovine	5.1	pKi	=	5.1	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
	CHEMBL294459	100981	3	None	-1862	4	Bovine	5.1	pKi	=	5.1	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
	14809026	205764	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL83080	205764	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	14809026	205764	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL83080	205764	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
	10551026	101590	0	None	-4677	6	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL298875	101590	0	None	-4677	6	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	44448067	155505	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
	CHEMBL404240	155505	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
	2	3237	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm901120h
	54562	3237	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm901120h
	CHEMBL240773	3237	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm901120h
	12050194	202868	1	None	-50	4	Bovine	4.1	pKi	=	4.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	333	5	0	4	3.7	c1ccc(CN2CCN(Cc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
	CHEMBL62703	202868	1	None	-50	4	Bovine	4.1	pKi	=	4.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	333	5	0	4	3.7	c1ccc(CN2CCN(Cc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
	133633	2228	53	None	-100	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
	177	2228	53	None	-100	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
	CHEMBL445102	2228	53	None	-100	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
	10378389	203222	1	None	-14454	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
	CHEMBL134807	203222	1	None	-14454	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
	CHEMBL64553	203222	1	None	-14454	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
	156020120	178009	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	340	3	0	5	3.4	COc1cc2c3c(c1OC)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4646927	178009	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	340	3	0	5	3.4	COc1cc2c3c(c1OC)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	15654860	203638	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ncccc32)CC1	10.1021/jm00067a009
	CHEMBL67355	203638	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ncccc32)CC1	10.1021/jm00067a009
	45481840	198036	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	267	4	0	2	4.1	CCCCC1c2cc(OC)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
	CHEMBL574110	198036	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	267	4	0	2	4.1	CCCCC1c2cc(OC)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
	6852376	91570	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
	CHEMBL1467585	91570	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
	CHEMBL24077	91570	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
	CHEMBL503958	91570	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
	10588326	158842	0	None	17	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL40950	158842	0	None	17	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
	44436608	146731	0	None	-870	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
	CHEMBL392437	146731	0	None	-870	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
	167715	2856	14	None	-954	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
	969	2856	14	None	-954	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
	CHEMBL225230	2856	14	None	-954	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
	3033276	13145	1	None	-1698	2	Rat	6.1	pKi	=	6.1	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	307	2	2	3	3.6	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(CC1CC1)CC3	10.1021/jm00163a007
	CHEMBL1190928	13145	1	None	-1698	2	Rat	6.1	pKi	=	6.1	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	307	2	2	3	3.6	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(CC1CC1)CC3	10.1021/jm00163a007
	CHEMBL541867	13145	1	None	-1698	2	Rat	6.1	pKi	=	6.1	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	307	2	2	3	3.6	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(CC1CC1)CC3	10.1021/jm00163a007
	25139331	169904	0	None	-1	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	310	9	2	2	3.9	CCCNCCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
	CHEMBL444128	169904	0	None	-1	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	310	9	2	2	3.9	CCCNCCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
	24823920	97418	0	None	-26	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
	CHEMBL270056	97418	0	None	-26	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
	53325137	58564	0	None	-37	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
	CHEMBL1684128	58564	0	None	-37	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
	10324985	76752	8	None	-5495	17	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL199824	76752	8	None	-5495	17	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL2068762	76752	8	None	-5495	17	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	14659294	167965	0	None	-3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	301	0	2	3	3.5	CN1CCc2cc(Cl)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	CHEMBL431946	167965	0	None	-3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	301	0	2	3	3.5	CN1CCc2cc(Cl)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	70692653	76037	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	CHEMBL2057443	76037	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
	70692653	76037	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
	CHEMBL2057443	76037	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
	129012255	154354	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)C1Cc3c(c(OC)cc(OC)c3OC)CN1CC2	nan
	CHEMBL3987156	154354	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)C1Cc3c(c(OC)cc(OC)c3OC)CN1CC2	nan
	71454295	84050	0	None	-933	7	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	536	8	0	6	5.5	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	CHEMBL2207641	84050	0	None	-933	7	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	536	8	0	6	5.5	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	57398875	69285	0	None	-213	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	4.7	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928138	69285	0	None	-213	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	4.7	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
	71474024	144443	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
	CHEMBL3906676	144443	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
	10551026	101590	0	None	-4677	6	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL298875	101590	0	None	-4677	6	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	15691846	204636	0	None	-10	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	335	3	1	3	3.4	O=C1CC(CN2CCC(O)(c3ccccc3)CC2)Cc2ccccc21	10.1021/jm00111a046
	CHEMBL73675	204636	0	None	-10	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	335	3	1	3	3.4	O=C1CC(CN2CCC(O)(c3ccccc3)CC2)Cc2ccccc21	10.1021/jm00111a046
	10672006	46789	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	467	5	1	3	5.5	CCCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
	CHEMBL154015	46789	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	467	5	1	3	5.5	CCCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
	14198588	171483	2	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
	CHEMBL446396	171483	2	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
	14198589	63044	2	None	35	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@@H]2c1ccccc1	10.1021/jm00118a012
	CHEMBL1788322	63044	2	None	35	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@@H]2c1ccccc1	10.1021/jm00118a012
	9928332	97151	5	None	-371	9	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assayCompound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assay	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1016/0960-894X(95)00398-D
	CHEMBL268258	97151	5	None	-371	9	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assayCompound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assay	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1016/0960-894X(95)00398-D
	2585	800	103	None	-112	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	522	800	103	None	-112	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	551	800	103	None	-112	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	CHEMBL723	800	103	None	-112	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	DB01136	800	103	None	-112	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	10665177	23111	0	None	56	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	344	5	2	3	3.8	NCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL133094	23111	0	None	56	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	344	5	2	3	3.8	NCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	10620219	6986	0	None	46	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	386	8	2	3	4.8	CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL108480	6986	0	None	46	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	386	8	2	3	4.8	CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	1353	1898	93	None	-74	86	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
	3559	1898	93	None	-74	86	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
	86	1898	93	None	-74	86	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
	CHEMBL54	1898	93	None	-74	86	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
	DB00502	1898	93	None	-74	86	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
	45482152	197987	0	None	-131	4	Pig	6.1	pKi	=	6.1	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	517	9	1	8	3.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cn(-c2ccc([N+](=O)[O-])cc2)nn1	10.1016/j.bmc.2009.06.041
	CHEMBL573792	197987	0	None	-131	4	Pig	6.1	pKi	=	6.1	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	517	9	1	8	3.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cn(-c2ccc([N+](=O)[O-])cc2)nn1	10.1016/j.bmc.2009.06.041
	4420454	56229	6	None	-41	5	Bovine	6.1	pKi	=	6.1	Binding	Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
	CHEMBL162762	56229	6	None	-41	5	Bovine	6.1	pKi	=	6.1	Binding	Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
	44400500	166036	0	None	-380	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL425731	166036	0	None	-380	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
	10980338	167984	0	None	-2454	4	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3ccc4ccnn4c3)CC2)cc1	10.1021/jm015522j
	CHEMBL432059	167984	0	None	-2454	4	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3ccc4ccnn4c3)CC2)cc1	10.1021/jm015522j
	10498094	32288	1	None	-5370	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4Cl)CC3)cc2c1	10.1021/jm0009989
	CHEMBL141035	32288	1	None	-5370	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4Cl)CC3)cc2c1	10.1021/jm0009989
	44412494	78292	0	None	-2630	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	352	4	0	4	3.8	Clc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	CHEMBL210955	78292	0	None	-2630	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	352	4	0	4	3.8	Clc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	137643132	158026	0	None	-6309	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	503	7	1	7	3.8	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1	10.1016/j.bmc.2017.04.036
	CHEMBL4085920	158026	0	None	-6309	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	503	7	1	7	3.8	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1	10.1016/j.bmc.2017.04.036
	44381146	58477	0	None	-18	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	CHEMBL168372	58477	0	None	-18	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	11639064	189918	0	None	-426	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	359	1	3	4	4.2	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL458579	189918	0	None	-426	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	359	1	3	4	4.2	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL517028	189918	0	None	-426	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	359	1	3	4	4.2	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	156012686	177338	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	352	3	1	4	3.4	COc1cc2c3c(c1OC)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4637673	177338	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	352	3	1	4	3.4	COc1cc2c3c(c1OC)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	118711258	113929	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)cc1	10.1016/j.ejmech.2014.07.059
	CHEMBL3325908	113929	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)cc1	10.1016/j.ejmech.2014.07.059
	10040938	44330	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	308	0	0	5	2.8	Cc1ccc2c(c1)N=C(N1CCN(C)CC1)c1cccnc1O2	10.1021/jm00030a011
	CHEMBL151809	44330	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	308	0	0	5	2.8	Cc1ccc2c(c1)N=C(N1CCN(C)CC1)c1cccnc1O2	10.1021/jm00030a011
	10044041	48913	0	None	-8	2	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	359	1	0	3	4.3	COc1ccc2c(c1)CC1c3c(ccc(Br)c3CCN1C)O2	10.1021/jm991034o
	CHEMBL156011	48913	0	None	-8	2	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	359	1	0	3	4.3	COc1ccc2c(c1)CC1c3c(ccc(Br)c3CCN1C)O2	10.1021/jm991034o
	1353	1898	93	None	-74	86	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
	3559	1898	93	None	-74	86	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
	86	1898	93	None	-74	86	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
	CHEMBL54	1898	93	None	-74	86	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
	DB00502	1898	93	None	-74	86	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
	156015018	177547	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	337	2	2	3	4.0	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL4640497	177547	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	337	2	2	3	4.0	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
	129103318	167290	0	None	-107	14	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	CHEMBL4293999	167290	0	None	-107	14	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	3038495	705	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
	7625	705	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
	CHEMBL25236	705	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
	3038495	705	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
	7625	705	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
	CHEMBL25236	705	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
	3038495	705	37	None	-512	19	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
	7625	705	37	None	-512	19	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
	CHEMBL25236	705	37	None	-512	19	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
	44263882	97196	0	None	-4	3	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4ccc5ccccc5c34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	CHEMBL268558	97196	0	None	-4	3	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4ccc5ccccc5c34)CC2)cc1	10.1016/s0960-894x(98)00692-1
	25333445	78094	5	None	-380	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3ccc(-n4cccn4)cc3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	CHEMBL210318	78094	5	None	-380	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3ccc(-n4cccn4)cc3)CC2)cc1	10.1016/j.bmcl.2006.02.075
	44567596	189759	0	None	-12	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	371	6	3	6	2.2	CN1CCc2cc(OCCOCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
	CHEMBL516151	189759	0	None	-12	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	371	6	3	6	2.2	CN1CCc2cc(OCCOCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
	126720252	164651	0	None	-269	12	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
	CHEMBL4216870	164651	0	None	-269	12	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
	11222444	130158	0	None	-27	3	Rat	5.1	pKi	=	5.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	369	4	0	5	4.1	CC(C)OCc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
	CHEMBL367875	130158	0	None	-27	3	Rat	5.1	pKi	=	5.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	369	4	0	5	4.1	CC(C)OCc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
	10873978	168462	0	None	-18620	6	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2o1	10.1021/jm0211220
	CHEMBL435218	168462	0	None	-18620	6	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2o1	10.1021/jm0211220
	117774120	132426	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	6	3.3	COC(=O)c1cccnc1Oc1ccc(-c2c(C)n[nH]c(=O)c2C)c(C)c1	nan
	CHEMBL3697592	132426	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	6	3.3	COC(=O)c1cccnc1Oc1ccc(-c2c(C)n[nH]c(=O)c2C)c(C)c1	nan
	26987	946	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	6063	946	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	671	946	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	CHEMBL1626	946	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	DB00283	946	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	11631304	73347	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	330	2	1	1	4.6	c1ccc2c(c1)CCN(CC1CC1)CCc1c([nH]c3ccccc13)C2	10.1021/jm050846j
	CHEMBL201432	73347	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	330	2	1	1	4.6	c1ccc2c(c1)CCN(CC1CC1)CCc1c([nH]c3ccccc13)C2	10.1021/jm050846j
	71817345	91950	0	None	-158	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
	CHEMBL2414992	91950	0	None	-158	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
	1588	2311	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
	28864	2311	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
	43	2311	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
	CHEMBL157138	2311	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
	DB00589	2311	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
	117949705	115171	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	4	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344468	115171	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	4	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	134150400	151956	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	397	7	2	5	4.7	CCCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3966718	151956	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	397	7	2	5	4.7	CCCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	44436618	147898	0	None	-512	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1ccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
	CHEMBL393365	147898	0	None	-512	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1ccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
	11581237	138933	0	None	-4897	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	357	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1	10.1021/jm060166w
	CHEMBL378515	138933	0	None	-4897	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	357	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1	10.1021/jm060166w
	137637428	156212	0	None	-9	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	250	1	1	5	0.9	CN1CCN(c2ccc(O)c3c2OCCO3)CC1	10.1016/j.bmc.2017.08.037
	CHEMBL4064759	156212	0	None	-9	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	250	1	1	5	0.9	CN1CCN(c2ccc(O)c3c2OCCO3)CC1	10.1016/j.bmc.2017.08.037
	72545010	93096	0	None	-229	5	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CF)[C@@H](O)[C@H](O)[C@H]3O)nn2)CC1	10.1016/j.bmcl.2013.09.026
	CHEMBL2443003	93096	0	None	-229	5	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CF)[C@@H](O)[C@H](O)[C@H]3O)nn2)CC1	10.1016/j.bmcl.2013.09.026
	11091738	118066	0	None	-11748	6	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm0211220
	CHEMBL340641	118066	0	None	-11748	6	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm0211220
	11102533	18025	0	None	-27	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	457	8	1	6	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2nc3ccccc3n3cccc23)CC1	10.1021/jm0211220
	CHEMBL126590	18025	0	None	-27	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	457	8	1	6	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2nc3ccccc3n3cccc23)CC1	10.1021/jm0211220
	2274	3151	58	None	-16	32	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	4917	3151	58	None	-16	32	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	7279	3151	58	None	-16	32	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	CHEMBL728	3151	58	None	-16	32	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	DB00433	3151	58	None	-16	32	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	44568533	188820	0	None	8	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	280	1	1	3	3.0	COc1cc2c3c(c1)-c1c(N)cccc1C[C@H]3N(C)CC2	10.1016/j.bmc.2008.05.077
	CHEMBL506721	188820	0	None	8	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	280	1	1	3	3.0	COc1cc2c3c(c1)-c1c(N)cccc1C[C@H]3N(C)CC2	10.1016/j.bmc.2008.05.077
	10758744	100479	0	None	11	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL291100	100479	0	None	11	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	162653702	180480	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
	CHEMBL4753299	180480	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
	11699469	77623	0	None	-48	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	537	8	1	5	5.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3c4ccc(c3o2)CCc2ccc(cc2)CC4)CC1	10.1021/jm060138d
	CHEMBL208847	77623	0	None	-48	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	537	8	1	5	5.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3c4ccc(c3o2)CCc2ccc(cc2)CC4)CC1	10.1021/jm060138d
	49783041	17139	0	None	-1949	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	597	7	1	3	6.8	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
	CHEMBL1256171	17139	0	None	-1949	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	597	7	1	3	6.8	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
	10826543	10069	0	None	-85	3	Rat	6.1	pKi	=	6.1	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	1	2	3.7	CCc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	CHEMBL115524	10069	0	None	-85	3	Rat	6.1	pKi	=	6.1	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	1	2	3.7	CCc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
	277	1289	62	None	-47	46	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2913	1289	62	None	-47	46	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	765	1289	62	None	-47	46	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	CHEMBL516	1289	62	None	-47	46	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	DB00434	1289	62	None	-47	46	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	44415382	81078	0	None	7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	4	1	5	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL215611	81078	0	None	7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	4	1	5	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	135398745	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
	47	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
	CHEMBL715	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
	DB00334	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
	44241718	195241	0	None	-281	4	Bovine	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	393	4	1	7	1.6	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccn4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
	CHEMBL551199	195241	0	None	-281	4	Bovine	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	393	4	1	7	1.6	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccn4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
	10709445	101336	0	None	26	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115377	101336	0	None	26	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL296993	101336	0	None	26	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	90644064	112009	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	7	0	4	5.0	Clc1ccc(N2CCN(CCCCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289649	112009	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	7	0	4	5.0	Clc1ccc(N2CCN(CCCCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
	154724609	176575	1	None	-9	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4514800	176575	1	None	-9	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4597637	176575	1	None	-9	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	53325242	57040	0	None	-4	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL1644978	57040	0	None	-4	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	15981509	141933	1	None	316	2	Pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
	CHEMBL387250	141933	1	None	316	2	Pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
	130907	194660	5	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
	CHEMBL53294	194660	5	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
	10448562	115094	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL334350	115094	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	9995986	28238	1	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL137420	28238	1	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
	10448562	115094	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL334350	115094	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	117773687	132403	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.6	C=C(C)c1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
	CHEMBL3697570	132403	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.6	C=C(C)c1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
	130442534	166873	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4286177	166873	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	10851849	169909	0	None	16	2	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL44414	169909	0	None	16	2	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	86764100	132451	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697617	132451	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	86764100	132451	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	391	3	1	5	3.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acs.jmedchem.8b01767
	CHEMBL3697617	132451	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	391	3	1	5	3.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acs.jmedchem.8b01767
	9818423	108222	0	None	34	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	281	0	3	3	3.0	Cc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
	CHEMBL319707	108222	0	None	34	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	281	0	3	3	3.0	Cc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
	15937719	18780	0	None	72	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	249	1	1	2	2.6	C#CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
	CHEMBL127843	18780	0	None	72	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	249	1	1	2	2.6	C#CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
	11522339	75223	1	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
	CHEMBL203689	75223	1	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
	173871	3587	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/jm00116a004
	936	3587	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/jm00116a004
	CHEMBL1193571	3587	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/jm00116a004
	75201901	166401	19	None	-1	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166401	19	None	-1	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	11716438	140857	1	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
	CHEMBL382010	140857	1	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
	163091	493	34	None	-147	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1039/C5MD00258C
	22	493	34	None	-147	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1039/C5MD00258C
	CHEMBL504548	493	34	None	-147	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1039/C5MD00258C
	6603797	67989	4	None	-2089	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	CHEMBL1257041	67989	4	None	-2089	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	CHEMBL19130	67989	4	None	-2089	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	44447997	95713	0	None	-20	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	4	0	3	3.9	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1cccc(OC=O)c1-3	10.1021/jm060959i
	CHEMBL258372	95713	0	None	-20	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	4	0	3	3.9	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1cccc(OC=O)c1-3	10.1021/jm060959i
	9888555	165580	16	None	-3235	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	CHEMBL424294	165580	16	None	-3235	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	137651936	157368	0	None	-1000	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4078348	157368	0	None	-1000	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	145990453	166921	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	404	7	2	4	4.1	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc3ccccc3c1)CC2	10.1021/acsmedchemlett.8b00229
	CHEMBL4287062	166921	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	404	7	2	4	4.1	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc3ccccc3c1)CC2	10.1021/acsmedchemlett.8b00229
	145993377	166944	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	430	8	2	4	4.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(-c3ccccc3)cc1)CC2	10.1021/acsmedchemlett.8b00229
	CHEMBL4287471	166944	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	430	8	2	4	4.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(-c3ccccc3)cc1)CC2	10.1021/acsmedchemlett.8b00229
	70690652	76541	0	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccc(Br)cc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
	CHEMBL2062857	76541	0	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccc(Br)cc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
	12050202	203275	0	None	-204	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CN[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL64752	203275	0	None	-204	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CN[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	44329067	207983	0	None	-154	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2ccc(C=O)c2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL97319	207983	0	None	-154	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2ccc(C=O)c2C1	10.1016/s0960-894x(01)00564-9
	1240	8791	17	None	-870	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL109684	8791	17	None	-870	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
	CHEMBL1256754	8791	17	None	-870	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
	44415758	80017	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	521	4	1	5	6.1	CC(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL212950	80017	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	521	4	1	5	6.1	CC(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	57391896	69276	0	None	-125	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1013	36	2	15	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928129	69276	0	None	-125	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1013	36	2	15	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	10758745	100405	0	None	18	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115373	100405	0	None	18	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL290438	100405	0	None	18	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	10427977	54435	0	None	-660	4	Bovine	6.1	pKi	=	6.1	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	350	3	0	4	3.3	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
	CHEMBL160952	54435	0	None	-660	4	Bovine	6.1	pKi	=	6.1	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	350	3	0	4	3.3	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
	57395341	69282	0	None	-426	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	2.8	CCOCCOCc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
	CHEMBL1928135	69282	0	None	-426	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	2.8	CCOCCOCc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
	9842468	9877	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
	CHEMBL114375	9877	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
	9842468	9877	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	CHEMBL114375	9877	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
	10088453	66045	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1016/j.bmcl.2004.06.005
	CHEMBL183776	66045	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1016/j.bmcl.2004.06.005
	10088453	66045	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1007/s00044-012-0055-5
	CHEMBL183776	66045	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1007/s00044-012-0055-5
	9972693	168501	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cccnc3Sc3ccccc32)CC1	10.1021/jm00030a011
	CHEMBL435441	168501	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cccnc3Sc3ccccc32)CC1	10.1021/jm00030a011
	76321554	106376	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
	CHEMBL3115574	106376	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
	CHEMBL3139450	106376	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
	14198577	198093	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	0	2	3.9	COc1cc2c(cc1Cl)CCN(C)C2c1ccccc1	10.1016/j.bmc.2009.05.079
	CHEMBL574557	198093	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	0	2	3.9	COc1cc2c(cc1Cl)CCN(C)C2c1ccccc1	10.1016/j.bmc.2009.05.079
	154726353	176299	1	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	467	12	2	3	5.9	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4577162	176299	1	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	467	12	2	3	5.9	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4595382	176299	1	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	467	12	2	3	5.9	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	1353	1898	93	None	-38	86	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
	3559	1898	93	None	-38	86	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
	86	1898	93	None	-38	86	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
	CHEMBL54	1898	93	None	-38	86	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
	DB00502	1898	93	None	-38	86	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
	11500677	140823	1	None	-6	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL381946	140823	1	None	-6	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	117773662	132413	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	3.7	CCc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)n(C)c(=O)[nH]c1=O	nan
	CHEMBL3697580	132413	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	3.7	CCc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)n(C)c(=O)[nH]c1=O	nan
	86764101	132452	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
	CHEMBL3697618	132452	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
	117773616	132388	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.1	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
	CHEMBL3697555	132388	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.1	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
	117773980	132406	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	2	6	2.3	Cc1cc(Oc2ncccc2O)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697573	132406	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	2	6	2.3	Cc1cc(Oc2ncccc2O)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	44393393	123647	0	None	-575	5	Pig	6.1	pKi	=	6.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	537	7	1	4	5.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)s1	10.1016/j.bmcl.2004.05.052
	CHEMBL362101	123647	0	None	-575	5	Pig	6.1	pKi	=	6.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	537	7	1	4	5.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)s1	10.1016/j.bmcl.2004.05.052
	9888555	165580	16	None	-3548	8	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm100899z
	CHEMBL424294	165580	16	None	-3548	8	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm100899z
	44340084	9056	0	None	-2238	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	CHEMBL109912	9056	0	None	-2238	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
	56597938	3909	3	None	-870	9	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	7651	3909	3	None	-870	9	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	CHEMBL2165126	3909	3	None	-870	9	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	117772974	132402	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	414	4	1	6	3.0	Cc1cc(Oc2ncccc2N2CC(F)(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697569	132402	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	414	4	1	6	3.0	Cc1cc(Oc2ncccc2N2CC(F)(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	44415648	80141	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL213472	80141	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	17755868	143093	1	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	0	1	2	3.8	CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1	10.1021/jm070388+
	CHEMBL389559	143093	1	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	0	1	2	3.8	CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1	10.1021/jm070388+
	44401243	168470	0	None	-34	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL435301	168470	0	None	-34	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	156022132	178193	0	None	-3	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	4	1	4	3.6	C=CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	CHEMBL4649785	178193	0	None	-3	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	4	1	4	3.6	C=CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
	10085358	110192	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
	CHEMBL323771	110192	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
	44448064	94845	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
	CHEMBL253947	94845	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
	44264641	204779	1	None	-11	3	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	230	2	0	4	1.1	CN1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
	CHEMBL7505	204779	1	None	-11	3	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	230	2	0	4	1.1	CN1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
	44329293	110041	0	None	-75	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
	CHEMBL323557	110041	0	None	-75	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
	145968810	165014	0	None	-120	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
	CHEMBL4226226	165014	0	None	-120	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
	154725813	176502	1	None	-31	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4568916	176502	1	None	-31	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4597047	176502	1	None	-31	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
	127031404	138777	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	4	2	5	3.2	COc1cc2c(cc1O)C(C)N(Cc1cccc(O)c1OC)CC2	10.1016/j.bmc.2016.03.037
	CHEMBL3780975	138777	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	4	2	5	3.2	COc1cc2c(cc1O)C(C)N(Cc1cccc(O)c1OC)CC2	10.1016/j.bmc.2016.03.037
	136043856	80078	0	None	-4	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	438	2	1	4	5.6	Fc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(F)c1	10.1016/j.bmcl.2006.06.034
	CHEMBL213200	80078	0	None	-4	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	438	2	1	4	5.6	Fc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(F)c1	10.1016/j.bmcl.2006.06.034
	71062708	154282	0	None	-47	12	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL3986651	154282	0	None	-47	12	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	90644060	112004	0	None	-64	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	358	4	0	2	4.4	Fc1ccc2c(c1)CC(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmc.2014.04.026
	CHEMBL3289644	112004	0	None	-64	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	358	4	0	2	4.4	Fc1ccc2c(c1)CC(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmc.2014.04.026
	103	4122	61	None	-28	54	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
	2875	4122	61	None	-28	54	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
	5736	4122	61	None	-28	54	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
	CHEMBL285802	4122	61	None	-28	54	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
	DB09225	4122	61	None	-28	54	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
	1248739	140061	16	None	-190	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	310	3	0	4	2.8	Fc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
	CHEMBL380054	140061	16	None	-190	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	310	3	0	4	2.8	Fc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
	44339984	167773	0	None	-186	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	CHEMBL430522	167773	0	None	-186	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
	135524323	195403	0	None	-3467	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	382	5	2	6	1.6	COc1ccccc1N1CCN(Cc2cc3c(=O)[nH]c(N(C)C)nc3[nH]2)CC1	10.1016/j.bmc.2009.05.015
	CHEMBL552268	195403	0	None	-3467	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	382	5	2	6	1.6	COc1ccccc1N1CCN(Cc2cc3c(=O)[nH]c(N(C)C)nc3[nH]2)CC1	10.1016/j.bmc.2009.05.015
	45272537	196503	0	None	-588	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
	CHEMBL563614	196503	0	None	-588	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
	135398745	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
	47	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
	CHEMBL715	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
	DB00334	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
	44415804	81446	0	None	147	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL215997	81446	0	None	147	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	135398745	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
	47	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
	CHEMBL715	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
	DB00334	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
	135398745	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
	47	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
	CHEMBL715	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
	DB00334	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
	135398745	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
	47	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
	CHEMBL715	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
	DB00334	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
	135398745	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
	47	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
	CHEMBL715	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
	DB00334	2893	112	None	-23	66	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
	15627811	194909	1	None	-8	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	CHEMBL54183	194909	1	None	-8	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	44405980	72027	0	None	-23	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
	CHEMBL197656	72027	0	None	-23	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
	1588	2311	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	28864	2311	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	43	2311	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	CHEMBL157138	2311	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	DB00589	2311	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	44415606	80087	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
	CHEMBL213239	80087	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
	44415823	141432	0	None	331	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccncc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL384248	141432	0	None	331	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccncc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
	44415473	79893	0	None	22	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	437	1	1	5	3.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL212486	79893	0	None	22	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	437	1	1	5	3.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	118709177	113398	0	None	-16	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1135	31	0	14	12.5	O=C(CCc1cn(CCCCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318850	113398	0	None	-16	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1135	31	0	14	12.5	O=C(CCc1cn(CCCCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	86764213	132424	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	1	5	4.2	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697590	132424	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	1	5	4.2	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	15711850	13207	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
	CHEMBL1191350	13207	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
	CHEMBL542436	13207	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
	117949627	115130	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	287	1	1	4	3.1	COc1cc2c(cc1O)[C@@H]1Cc3sccc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344356	115130	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	287	1	1	4	3.1	COc1cc2c(cc1O)[C@@H]1Cc3sccc3CN1CC2	10.1016/j.bmc.2014.09.024
	44436621	91002	0	None	-151	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1cccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
	CHEMBL239733	91002	0	None	-151	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1cccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
	71456045	84044	0	None	-1202	6	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	362	5	1	4	3.6	COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	CHEMBL2207635	84044	0	None	-1202	6	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	362	5	1	4	3.6	COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
	127046952	140076	0	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	421	12	3	5	4.5	COc1cc(CCNCCc2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	CHEMBL3800636	140076	0	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	421	12	3	5	4.5	COc1cc(CCNCCc2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	25093832	155856	0	None	-2290	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4060461	155856	0	None	-2290	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	137640391	156681	0	None	-1096	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	418	7	1	7	2.8	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4070091	156681	0	None	-1096	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	418	7	1	7	2.8	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	137635364	156236	0	None	-2754	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	439	10	1	6	3.0	O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
	CHEMBL4064974	156236	0	None	-2754	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	439	10	1	6	3.0	O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
	CHEMBL4074669	156236	0	None	-2754	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	439	10	1	6	3.0	O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
	10314824	35350	1	None	-8511	5	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm0009989
	CHEMBL143761	35350	1	None	-8511	5	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm0009989
	10314824	35350	1	None	-8511	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm060166w
	CHEMBL143761	35350	1	None	-8511	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm060166w
	44448060	155220	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
	CHEMBL402735	155220	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
	137657153	159533	0	None	-776	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4102616	159533	0	None	-776	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	85658088	164979	0	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	219	4	1	2	3.0	CCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4225830	164979	0	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	219	4	1	2	3.0	CCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	1043	1569	14	None	-9549	29	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	149	1569	14	None	-9549	29	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	8223	1569	14	None	-9549	29	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL442	1569	14	None	-9549	29	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00696	1569	14	None	-9549	29	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	135986088	178091	0	None	-263	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	543	7	1	6	6.5	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2	10.1016/j.bmcl.2008.09.012
	CHEMBL464811	178091	0	None	-263	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	543	7	1	6	6.5	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2	10.1016/j.bmcl.2008.09.012
	76321554	106376	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
	CHEMBL3115574	106376	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
	CHEMBL3139450	106376	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
	112500029	132440	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	0	6	3.9	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)ncc(=O)n1C	nan
	CHEMBL3697606	132440	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	0	6	3.9	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)ncc(=O)n1C	nan
	14198596	101616	0	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
	CHEMBL299056	101616	0	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
	14198597	102097	1	None	3	2	Human	7.1	pKi	=	7.1	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00129a006
	CHEMBL302393	102097	1	None	3	2	Human	7.1	pKi	=	7.1	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00129a006
	117772840	132410	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	343	3	1	5	2.9	Cc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
	CHEMBL3697577	132410	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	343	3	1	5	2.9	Cc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
	44320129	167870	0	None	-1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL431220	167870	0	None	-1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	16105548	82669	0	None	-2344	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1	10.1021/jm0611152
	CHEMBL217964	82669	0	None	-2344	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1	10.1021/jm0611152
	CHEMBL221652	82669	0	None	-2344	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1	10.1021/jm0611152
	53363200	63823	0	None	-134	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	509	14	0	9	3.7	CCOCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
	CHEMBL1803052	63823	0	None	-134	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	509	14	0	9	3.7	CCOCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
	11682812	78180	0	None	-5495	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	402	5	0	7	3.2	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1	10.1021/jm060166w
	CHEMBL210551	78180	0	None	-5495	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	402	5	0	7	3.2	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1	10.1021/jm060166w
	2	3237	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2016.04.028
	54562	3237	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2016.04.028
	CHEMBL240773	3237	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2016.04.028
	2	3237	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm501889t
	54562	3237	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm501889t
	CHEMBL240773	3237	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm501889t
	44380716	59057	0	None	-12	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	CHEMBL169631	59057	0	None	-12	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
	2	3237	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm400520c
	54562	3237	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm400520c
	CHEMBL240773	3237	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm400520c
	2	3237	23	None	-977	29	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
	54562	3237	23	None	-977	29	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
	CHEMBL240773	3237	23	None	-977	29	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
	44582179	181401	0	None	-57	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	379	6	0	5	2.5	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL476393	181401	0	None	-57	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	379	6	0	5	2.5	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2009.01.067
	154706431	176561	1	None	-77	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	451	12	2	3	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4531363	176561	1	None	-77	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	451	12	2	3	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4597531	176561	1	None	-77	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	451	12	2	3	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	1220	187	55	None	-69183	45	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
	31	187	55	None	-69183	45	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
	7	187	55	None	-69183	45	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
	CHEMBL56	187	55	None	-69183	45	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
	44591012	175556	0	None	-177	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	CHEMBL457957	175556	0	None	-177	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	44386883	60370	0	None	-1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	328	3	1	4	3.2	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CNCC2	10.1016/s0960-894x(98)00138-3
	CHEMBL174949	60370	0	None	-1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	328	3	1	4	3.2	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CNCC2	10.1016/s0960-894x(98)00138-3
	44415845	79984	0	None	34	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	511	3	1	7	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3-n3ccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL212844	79984	0	None	34	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	511	3	1	7	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3-n3ccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	11515697	178208	0	None	-11	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL458397	178208	0	None	-11	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL465054	178208	0	None	-11	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	86767093	129397	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
	CHEMBL3671280	129397	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
	10574176	9930	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	420	5	1	3	5.3	CN(C)c1ccc(CCN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	CHEMBL114726	9930	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	420	5	1	3	5.3	CN(C)c1ccc(CCN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	44320026	206076	0	None	3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85689	206076	0	None	3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	117774323	132394	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.9	Cc1cc(Oc2ncc(Cl)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697561	132394	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.9	Cc1cc(Oc2ncc(Cl)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	10643780	119369	0	None	-97	4	Bovine	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)[nH]c2c1	10.1021/jm0009989
	CHEMBL344602	119369	0	None	-97	4	Bovine	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)[nH]c2c1	10.1021/jm0009989
	10276451	200262	37	None	-12022	10	Human	5.1	pKi	=	5.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm025558r
	CHEMBL2112910	200262	37	None	-12022	10	Human	5.1	pKi	=	5.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm025558r
	CHEMBL59725	200262	37	None	-12022	10	Human	5.1	pKi	=	5.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm025558r
	10276451	200262	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2004.05.052
	CHEMBL2112910	200262	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2004.05.052
	CHEMBL59725	200262	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2004.05.052
	10276451	200262	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2005.07.037
	CHEMBL2112910	200262	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2005.07.037
	CHEMBL59725	200262	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2005.07.037
	137632607	156315	0	None	-2344	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	305	3	2	5	1.6	CCCN1CCCN(c2ccc(O)c3c2OCC(=O)N3)CC1	10.1016/j.bmc.2017.08.037
	CHEMBL4065797	156315	0	None	-2344	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	305	3	2	5	1.6	CCCN1CCCN(c2ccc(O)c3c2OCC(=O)N3)CC1	10.1016/j.bmc.2017.08.037
	44278298	99136	0	None	-2884	3	Rat	4.1	pKi	=	4.1	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	348	4	0	2	4.3	O=C(c1cccc(CN2CCC(c3ccccc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
	CHEMBL281214	99136	0	None	-2884	3	Rat	4.1	pKi	=	4.1	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	348	4	0	2	4.3	O=C(c1cccc(CN2CCC(c3ccccc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
	44304652	200299	0	None	-28	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
	CHEMBL59749	200299	0	None	-28	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
	44415622	138578	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	591	4	1	5	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc(F)cc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	CHEMBL377564	138578	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	591	4	1	5	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc(F)cc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
	228	444	28	None	-30	24	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
	33	444	28	None	-30	24	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
	6005	444	28	None	-30	24	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
	CHEMBL53	444	28	None	-30	24	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
	DB00714	444	28	None	-30	24	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
	180	400	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
	200	400	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
	2160	400	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
	CHEMBL629	400	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
	DB00321	400	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
	135398737	955	93	None	-44	92	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
	38	955	93	None	-44	92	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
	722	955	93	None	-44	92	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
	CHEMBL42	955	93	None	-44	92	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
	DB00363	955	93	None	-44	92	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
	44276652	99466	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	CHEMBL283247	99466	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	127045855	139639	0	None	-9	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
	CHEMBL3797876	139639	0	None	-9	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
	44381276	58698	0	None	-2	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
	CHEMBL168541	58698	0	None	-2	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
	44304644	203228	0	None	-8	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	454	8	2	4	4.5	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)c[nH]1	10.1016/s0960-894x(00)00405-4
	CHEMBL64566	203228	0	None	-8	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	454	8	2	4	4.5	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)c[nH]1	10.1016/s0960-894x(00)00405-4
	154703922	176265	1	None	-446	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4590211	176265	1	None	-446	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4595146	176265	1	None	-446	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	154703824	176602	1	None	-346	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4456007	176602	1	None	-346	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4597876	176602	1	None	-346	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	181743	178548	5	None	-446	22	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH233930 from human dopamine D1 receptorDisplacement of [3H]SCH233930 from human dopamine D1 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	CHEMBL467094	178548	5	None	-446	22	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH233930 from human dopamine D1 receptorDisplacement of [3H]SCH233930 from human dopamine D1 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	242	469	124	None	-281	52	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	34	469	124	None	-281	52	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	60795	469	124	None	-281	52	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	CHEMBL1112	469	124	None	-281	52	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	DB01238	469	124	None	-281	52	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	44304621	203396	0	None	-74	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	CHEMBL65641	203396	0	None	-74	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
	6101909	100909	1	None	1	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
	CHEMBL294012	100909	1	None	1	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
	6101909	100909	1	None	-1	3	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
	CHEMBL294012	100909	1	None	-1	3	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
	44455426	155125	0	None	-12	12	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL402143	155125	0	None	-12	12	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	44415629	80001	0	None	338	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccsc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL212896	80001	0	None	338	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccsc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	10107367	102407	1	None	-7	4	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	CHEMBL303993	102407	1	None	-7	4	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
	44385980	61354	0	None	3	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	268	1	1	2	3.2	Fc1ccc(N2CC3CNCCc4cccc2c43)cc1	10.1016/s0960-894x(98)00138-3
	CHEMBL176990	61354	0	None	3	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	268	1	1	2	3.2	Fc1ccc(N2CC3CNCCc4cccc2c43)cc1	10.1016/s0960-894x(98)00138-3
	11558247	75393	0	None	2	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	CHEMBL204098	75393	0	None	2	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	86764211	132420	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697587	132420	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	11573806	75387	0	None	-7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	CHEMBL204065	75387	0	None	-7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	2865	4112	73	None	-114	54	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
	59	4112	73	None	-114	54	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
	60854	4112	73	None	-114	54	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
	CHEMBL708	4112	73	None	-114	54	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
	DB00246	4112	73	None	-114	54	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
	1353	1898	93	None	-30	86	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
	3559	1898	93	None	-30	86	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
	86	1898	93	None	-30	86	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
	CHEMBL54	1898	93	None	-30	86	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
	DB00502	1898	93	None	-30	86	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
	10830233	202830	0	None	8	2	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	329	0	2	1	4.3	CN1CCc2c([nH]c3ccccc23)Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
	CHEMBL62529	202830	0	None	8	2	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	329	0	2	1	4.3	CN1CCc2c([nH]c3ccccc23)Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
	117774170	132409	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	385	3	1	4	4.3	Cc1cc(Oc2ncccc2Br)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697576	132409	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	385	3	1	4	4.3	Cc1cc(Oc2ncccc2Br)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	134137323	142942	0	None	33	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	4	2	5	4.7	CCC(C)Oc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	CHEMBL3894329	142942	0	None	33	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	4	2	5	4.7	CCC(C)Oc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
	74223724	129391	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3671274	129391	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	74223777	129409	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	350	3	1	4	5.1	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1Cl	nan
	CHEMBL3671291	129409	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	350	3	1	4	5.1	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1Cl	nan
	44393403	65048	0	None	-891	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
	CHEMBL182379	65048	0	None	-891	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
	137655735	158968	0	None	-1230	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	8	2	8	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(/C=N\O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4096353	158968	0	None	-1230	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	8	2	8	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(/C=N\O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	52943802	17586	0	None	-199	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	363	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
	CHEMBL1258270	17586	0	None	-199	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	363	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
	44319368	106037	0	None	-7	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
	CHEMBL313320	106037	0	None	-7	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
	10807793	202956	1	None	7	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	350	2	1	3	3.8	COc1cc2c(cc1OC)Cc1[nH]c3ccccc3c1CCN(C)CC2	10.1021/jm9911478
	CHEMBL63063	202956	1	None	7	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	350	2	1	3	3.8	COc1cc2c(cc1OC)Cc1[nH]c3ccccc3c1CCN(C)CC2	10.1021/jm9911478
	164627027	186403	0	None	-45	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	466	5	3	4	4.3	O=C(NCc1ccccc1CN1CCc2cc(O)c(O)cc2C1)c1cccc(Br)c1	10.1016/j.bmcl.2021.128047
	CHEMBL4876260	186403	0	None	-45	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	466	5	3	4	4.3	O=C(NCc1ccccc1CN1CCc2cc(O)c(O)cc2C1)c1cccc(Br)c1	10.1016/j.bmcl.2021.128047
	44403224	71886	0	None	-102	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(F)n1	10.1016/j.bmcl.2005.07.037
	CHEMBL197195	71886	0	None	-102	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(F)n1	10.1016/j.bmcl.2005.07.037
	44436605	149039	0	None	-2951	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
	CHEMBL394292	149039	0	None	-2951	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
	53318564	58565	0	None	-8	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	646	14	0	7	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCN(CCCN2CCN(c4ccccc4OC)CC2)S(C)(=O)=O)c1-3	10.1016/j.bmc.2011.01.053
	CHEMBL1684129	58565	0	None	-8	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	646	14	0	7	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCN(CCCN2CCN(c4ccccc4OC)CC2)S(C)(=O)=O)c1-3	10.1016/j.bmc.2011.01.053
	57390119	69274	0	None	-218	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	969	33	2	14	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	CHEMBL1928127	69274	0	None	-218	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	969	33	2	14	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
	44381286	120341	0	None	-4	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
	CHEMBL353220	120341	0	None	-4	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
	118711263	113931	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1ccccc1-c1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
	CHEMBL3325914	113931	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1ccccc1-c1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
	10432606	204491	0	None	-11	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	426	7	0	4	4.0	O=C(CCCN1CCN(CC2CC(=O)c3ccc(F)cc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
	CHEMBL72649	204491	0	None	-11	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	426	7	0	4	4.0	O=C(CCCN1CCN(CC2CC(=O)c3ccc(F)cc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
	10402195	41496	1	None	1	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3Oc3ccccc32)CC1	10.1021/jm00030a011
	CHEMBL149108	41496	1	None	1	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3Oc3ccccc32)CC1	10.1021/jm00030a011
	6603798	100152	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	CHEMBL1613539	100152	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	CHEMBL288096	100152	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
	117773861	132390	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2ncc(Cl)cc2C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	CHEMBL3697557	132390	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2ncc(Cl)cc2C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
	44403213	71758	4	None	-1737	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	423	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
	CHEMBL196744	71758	4	None	-1737	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	423	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
	54581964	61578	0	None	-3162	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	489	8	0	5	5.4	COc1ccccc1N1CCN(CCCCN2CCCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771111	61578	0	None	-3162	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	489	8	0	5	5.4	COc1ccccc1N1CCN(CCCCN2CCCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	6603798	100152	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	CHEMBL1613539	100152	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	CHEMBL288096	100152	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
	137659303	159280	0	None	-154	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4099711	159280	0	None	-154	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	118709163	113382	0	None	-338	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	888	21	0	8	11.3	O=C(CCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318835	113382	0	None	-338	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	888	21	0	8	11.3	O=C(CCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	12050196	203095	6	None	-15	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	349	5	0	4	4.1	c1ccc(CN2CCN(Cc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
	CHEMBL64043	203095	6	None	-15	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	349	5	0	4	4.1	c1ccc(CN2CCN(Cc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
	71462090	84564	0	None	-831	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
	CHEMBL2158640	84564	0	None	-831	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
	CHEMBL2221044	84564	0	None	-831	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
	24949535	181535	0	None	-1122	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
	CHEMBL476722	181535	0	None	-1122	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
	177511	101515	23	None	-14	2	Rat	5.0	pKi	=	5.0	Binding	The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.	ChEMBL	255	2	3	3	2.5	Oc1cc2c(cc1O)C(Cc1ccccc1)NCC2	10.1016/s0960-894x(00)00326-7
	CHEMBL298285	101515	23	None	-14	2	Rat	5.0	pKi	=	5.0	Binding	The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.	ChEMBL	255	2	3	3	2.5	Oc1cc2c(cc1O)C(Cc1ccccc1)NCC2	10.1016/s0960-894x(00)00326-7
	156013773	177249	0	None	-9	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	280	1	0	3	3.3	CN1CCc2cccc3c2C1Cc1ccc([N+](=O)[O-])cc1-3	10.1016/j.bmcl.2020.127053
	CHEMBL4636242	177249	0	None	-9	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	280	1	0	3	3.3	CN1CCc2cccc3c2C1Cc1ccc([N+](=O)[O-])cc1-3	10.1016/j.bmcl.2020.127053
	1353	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
	3559	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
	86	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
	CHEMBL54	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
	DB00502	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
	1353	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
	3559	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
	86	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
	CHEMBL54	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
	DB00502	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
	74223773	129398	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)nc[n+]([O-])c1C	nan
	CHEMBL3671281	129398	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)nc[n+]([O-])c1C	nan
	154725276	176266	1	None	-34	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4456964	176266	1	None	-34	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4595147	176266	1	None	-34	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	25071692	111762	0	None	-2187	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287405	111762	0	None	-2187	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	118709169	113389	0	None	-6	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1029	31	0	8	15.2	O=C(CCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	CHEMBL3318841	113389	0	None	-6	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1029	31	0	8	15.2	O=C(CCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
	44372009	48809	0	None	-123	4	Bovine	6.0	pKi	=	6.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	402	4	0	4	5.0	Clc1ccc(N2CCN(Cc3cnn4c(-c5ccccc5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
	CHEMBL155913	48809	0	None	-123	4	Bovine	6.0	pKi	=	6.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	402	4	0	4	5.0	Clc1ccc(N2CCN(Cc3cnn4c(-c5ccccc5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
	42626103	56223	0	None	-2137	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	442	6	2	3	4.6	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	CHEMBL1627323	56223	0	None	-2137	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	442	6	2	3	4.6	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	44241577	13982	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	387	3	3	4	5.0	CCCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL1197140	13982	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	387	3	3	4	5.0	CCCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	CHEMBL560721	13982	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	387	3	3	4	5.0	CCCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
	117773063	132417	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	4	1	5	4.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	CHEMBL3697584	132417	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	4	1	5	4.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
	154725001	176623	1	None	-60	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4525624	176623	1	None	-60	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4598002	176623	1	None	-60	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
	44344506	13796	0	None	-8	2	Rat	5.0	pKi	=	5.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	327	1	1	2	4.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(-c2ccccc2)c(O)c1-3	10.1021/jm960188q
	CHEMBL119577	13796	0	None	-8	2	Rat	5.0	pKi	=	5.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	327	1	1	2	4.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(-c2ccccc2)c(O)c1-3	10.1021/jm960188q
	CHEMBL4802048	214038	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CC[C@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O	10.6019/CHEMBL4800729
	25139479	184293	0	None	-1071	4	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	438	10	0	4	6.2	C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1	10.1021/jm800895v
	CHEMBL484202	184293	0	None	-1071	4	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	438	10	0	4	6.2	C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1	10.1021/jm800895v
	45483655	198092	0	None	-138	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7ccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)cc7)nn6)cc5)cc4)nn3)cc2)CC1	10.1021/jm901120h
	CHEMBL574534	198092	0	None	-138	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7ccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)cc7)nn6)cc5)cc4)nn3)cc2)CC1	10.1021/jm901120h
	71110301	92169	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL2425371	92169	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
	CHEMBL4802048	214038	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CC[C@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O	10.6019/CHEMBL4800729
	2726	916	68	None	-36	73	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
	621	916	68	None	-36	73	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
	83	916	68	None	-36	73	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
	CHEMBL71	916	68	None	-36	73	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
	DB00477	916	68	None	-36	73	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
	127047859	140026	0	None	-338	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	476	12	3	6	4.1	COc1cc(CCNCCc2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	CHEMBL3800341	140026	0	None	-338	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	476	12	3	6	4.1	COc1cc(CCNCCc2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
	45481877	198106	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	10	2	10	3.6	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5ncccn5)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
	CHEMBL574627	198106	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	10	2	10	3.6	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5ncccn5)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
	3082625	194705	8	None	-199	4	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2007.05.057
	CHEMBL53510	194705	8	None	-199	4	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2007.05.057
	154705128	176267	1	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4454872	176267	1	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4595148	176267	1	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	100	3776	58	None	-47	56	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2637	3776	58	None	-47	56	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	5452	3776	58	None	-47	56	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	CHEMBL479	3776	58	None	-47	56	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	DB00679	3776	58	None	-47	56	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	86767094	129400	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cncc2nccn12	nan
	CHEMBL3671283	129400	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cncc2nccn12	nan
	1353	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
	3559	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
	86	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
	CHEMBL54	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
	DB00502	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
	1353	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
	3559	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
	86	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
	CHEMBL54	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
	DB00502	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
	1353	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
	3559	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
	86	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
	CHEMBL54	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
	DB00502	1898	93	None	-74	86	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
	10454026	17875	0	None	-3019	9	Rat	6.0	pKi	=	6.0	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	406	8	2	4	3.5	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0211220
	CHEMBL125916	17875	0	None	-3019	9	Rat	6.0	pKi	=	6.0	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	406	8	2	4	3.5	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0211220
	10058098	198584	9	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligandCompound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligand	ChEMBL	179	0	3	3	0.8	Oc1cc2c(cc1O)CCNCC2	10.1021/jm00160a018
	CHEMBL57873	198584	9	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligandCompound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligand	ChEMBL	179	0	3	3	0.8	Oc1cc2c(cc1O)CCNCC2	10.1021/jm00160a018
	11678172	78003	0	None	-2137	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	531	8	1	4	5.6	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
	CHEMBL209876	78003	0	None	-2137	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	531	8	1	4	5.6	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
	25071384	111754	0	None	-251	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287397	111754	0	None	-251	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	44381118	57539	0	None	-426	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
	CHEMBL166587	57539	0	None	-426	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
	44319102	206118	0	None	-16	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
	CHEMBL86060	206118	0	None	-16	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
	44582187	181546	0	None	-47	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	8	0	4	3.7	COc1ccccc1N1CCN(CCCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
	CHEMBL476808	181546	0	None	-47	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	8	0	4	3.7	COc1ccccc1N1CCN(CCCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
	44323870	111564	0	None	3	4	Rat	7.0	pKi	=	7.0	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
	CHEMBL328246	111564	0	None	3	4	Rat	7.0	pKi	=	7.0	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
	25142456	82377	2	None	-48	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
	CHEMBL217299	82377	2	None	-48	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
	44415685	80138	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	551	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL213466	80138	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	551	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	44415450	139598	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	425	1	1	5	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(C)(C)C)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL379757	139598	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	425	1	1	5	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(C)(C)C)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	1353	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
	3559	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
	86	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
	CHEMBL54	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
	DB00502	1898	93	None	-30	86	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
	118445551	167291	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
	CHEMBL4294009	167291	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
	53363201	63825	0	None	-114	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	893	27	0	15	7.0	COc1cc(CN2CCN(C)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	CHEMBL1803054	63825	0	None	-114	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	893	27	0	15	7.0	COc1cc(CN2CCN(C)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
	71722297	102445	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397382	102445	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040156	102445	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	49782601	17456	0	None	-602	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	487	6	1	3	6.2	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
	CHEMBL1257810	17456	0	None	-602	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	487	6	1	3	6.2	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
	10561522	36171	0	None	-51	2	Bovine	4.0	pKi	=	4.0	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2c(C)cccc2C)C1	10.1021/jm9708700
	CHEMBL144501	36171	0	None	-51	2	Bovine	4.0	pKi	=	4.0	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2c(C)cccc2C)C1	10.1021/jm9708700
	154705520	176236	1	None	-64	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4452683	176236	1	None	-64	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4594959	176236	1	None	-64	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	2750	204038	76	None	-5	12	Human	5.0	pKi	=	5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	CHEMBL7002	204038	76	None	-5	12	Human	5.0	pKi	=	5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	15115519	207184	0	None	-151	2	Human	7.0	pKi	=	7	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	677	12	1	10	6.4	O=C(CCCN1CCC2(CC1)C(=O)N(CCc1ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc1)CN2c1ccccc1)c1ccc(F)cc1	10.1021/jm00115a012
	CHEMBL92649	207184	0	None	-151	2	Human	7.0	pKi	=	7	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	677	12	1	10	6.4	O=C(CCCN1CCC2(CC1)C(=O)N(CCc1ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc1)CN2c1ccccc1)c1ccc(F)cc1	10.1021/jm00115a012
	44415605	80086	0	None	11	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	CHEMBL213238	80086	0	None	11	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
	42625205	56224	0	None	-89	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	405	7	1	5	3.6	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
	CHEMBL1627324	56224	0	None	-89	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	405	7	1	5	3.6	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
	3303	2231	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(98)00692-1
	5311200	2231	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(98)00692-1
	CHEMBL267014	2231	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(98)00692-1
	3303	2231	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/j.bmc.2009.05.015
	5311200	2231	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/j.bmc.2009.05.015
	CHEMBL267014	2231	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/j.bmc.2009.05.015
	24824066	157356	0	None	-2	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
	CHEMBL407818	157356	0	None	-2	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
	3303	2231	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00814-9
	5311200	2231	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00814-9
	CHEMBL267014	2231	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00814-9
	154706703	176208	1	None	-17	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4550187	176208	1	None	-17	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4594691	176208	1	None	-17	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	154725749	176664	1	None	-91	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4453478	176664	1	None	-91	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
	CHEMBL4598388	176664	1	None	-91	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
	240	941	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	941	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	941	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	941	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	941	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	941	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	941	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	3294	1993	111	None	-	45	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	None	-	45	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	None	-	45	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	None	-	45	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	None	-	45	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	2601	3751	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3751	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3751	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3751	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3751	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	100	3776	58	None	-16	56	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	None	-16	56	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	None	-16	56	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	None	-16	56	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	None	-16	56	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5281878	1647	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1028	289	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	139148732	289	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	479	289	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	5816	289	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	CHEMBL679	289	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	DB00668	289	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	1960	2838	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
	439260	2838	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
	505	2838	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
	CHEMBL1437	2838	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
	DB00368	2838	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
	1153	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	12668023	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	30026874	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	30026875	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	3341	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	6603851	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	933	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	939	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	985	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL1160786	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL1161520	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL588	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	DB00800	1615	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	2869	4121	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
	60	4121	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
	60857	4121	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
	CHEMBL1185	4121	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
	DB00315	4121	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
	5018	3523	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
	943	3523	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
	946	3523	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
	CHEMBL13668	3523	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
	3036864	202731	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	3036864	202731	19	3H-SCH23390	2	28	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	3036864	202731	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	2	28	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	2	28	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	2	28	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	None	216358	0	3H-SCH23390	5495	2	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	329	1	1	3	3.6	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OCC4)O)Cl	None
	None	216356	0	3H-SCH23390	165	2	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	327	1	1	3	4.4	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OC=C4)O)Cl	None
	3036864	202731	19	3H-SCH23390	-2	28	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-2	28	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-2	28	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-2	28	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	1242	3586	27	3H-SCH23390	1	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	3H-SCH23390	1	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	3H-SCH23390	1	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	1243	3591	34	3H-SCH23390	3	5	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	None
	944	3591	34	3H-SCH23390	3	5	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	None
	CHEMBL324017	3591	34	3H-SCH23390	3	5	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	None
	5281878	1647	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281878	1647	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3036864	202731	19	3H-SCH23390	-2	28	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-2	28	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-2	28	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-2	28	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	3036864	202731	19	3H-SCH23390	-2	28	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-2	28	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-2	28	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-2	28	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	3036864	202731	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	3036864	202731	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	25058166	215935	0	3H-SCH23390 High	-6	27	Bovine	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-SCH23390 High	-6	27	Bovine	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	3036864	202731	19	3H-SCH23390	-26	28	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-26	28	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-26	28	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-26	28	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	3036864	202731	19	3H-SCH23390	-3	28	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-3	28	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-3	28	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-3	28	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	5018	3523	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	5018	3523	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	943	3523	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	943	3523	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	946	3523	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	946	3523	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	CHEMBL13668	3523	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	CHEMBL13668	3523	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	3036864	202731	19	3H-SCH23390	-2	28	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-2	28	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-2	28	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-2	28	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	37459	743	13	3H-SCH23390	-2	25	Mouse	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	37459	743	13	3H-SCH23390	-8	25	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-SCH23390	-2	25	Mouse	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-SCH23390	-8	25	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-SCH23390	-2	25	Mouse	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-SCH23390	-8	25	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	133538	3592	24	3H-SCH23390	1	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	None
	8443	3592	24	3H-SCH23390	1	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	None
	CHEMBL574558	3592	24	3H-SCH23390	1	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	None
	3036864	202731	19	3H-SCH23390	-3	28	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-3	28	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-3	28	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-3	28	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	3036864	202731	19	3H-SCH23390	-2	28	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-2	28	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-2	28	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-2	28	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	1218	3589	30	3H-SCH23390	11	8	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
	938	3589	30	3H-SCH23390	11	8	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
	CHEMBL353335	3589	30	3H-SCH23390	11	8	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
	None	216360	0	3H-SCH23390	436	2	Mouse	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	349	1	2	3	3.3	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)O.Br	None
	135398745	2893	112	UNDEFINED	-23	66	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	UNDEFINED	-23	66	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	UNDEFINED	-23	66	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	UNDEFINED	-23	66	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	6603820	95745	19	3H-SCH23390	1	13	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	CHEMBL25856	95745	19	3H-SCH23390	1	13	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	1241	100151	24	3H-SCH23390	-1	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
	CHEMBL288090	100151	24	3H-SCH23390	-1	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
	CHEMBL552611	100151	24	3H-SCH23390	-1	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
	135398745	2893	112	3H-SCH23390	-23	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-SCH23390	-23	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-SCH23390	-23	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-SCH23390	-23	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	100	3776	58	3H-SCH23390	-47	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-SCH23390	-47	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-SCH23390	-47	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-SCH23390	-47	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-SCH23390	-47	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	202	1496	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1496	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1496	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1496	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1496	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	2	3237	23	3H-SCH23390	-208	29	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	54562	3237	23	3H-SCH23390	-208	29	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	CHEMBL240773	3237	23	3H-SCH23390	-208	29	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	121881	3464	27	3H-SCH23390	-48977	15	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
	256	3464	27	3H-SCH23390	-48977	15	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
	CHEMBL68131	3464	27	3H-SCH23390	-48977	15	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
	46222048	8952	0	UNDEFINED	-4365	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	None
	CHEMBL1098230	8952	0	UNDEFINED	-4365	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	None
	18922713	98470	0	3H-SCH23390	-12882	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	None
	CHEMBL276031	98470	0	3H-SCH23390	-12882	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	None
	24840389	115187	4	3H-SCH23390	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
	CHEMBL334529	115187	4	3H-SCH23390	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
	44591098	176738	0	UNDEFINED	-288	6	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	508	9	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1	None
	CHEMBL460402	176738	0	UNDEFINED	-288	6	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	508	9	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1	None
	12016890	190752	6	3H-SCH23390	-1698	12	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
	CHEMBL5183389	190752	6	3H-SCH23390	-1698	12	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
	5656	203043	87	UNDEFINED	-25	43	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	CHEMBL637	203043	87	UNDEFINED	-25	43	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	54841	203104	52	UNDEFINED	-1	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
	CHEMBL641	203104	52	UNDEFINED	-1	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
	None	215967	0	3H-SCH23390	-107	11	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.2	C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl	None
	104911	215994	0	3H-SCH23390	-4168	38	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
	3075702	217305	0	3H-SCH23390	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
	1574	81	60	3H-SCH23390	-107	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	60	3H-SCH23390	-107	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	60	3H-SCH23390	-107	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	5	139	72	3H-SCH23390 Low	-23442	55	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	72	3H-SCH23390	-23442	55	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	72	3H-SCH23390	-16595	55	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-SCH23390 Low	-23442	55	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-SCH23390	-23442	55	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-SCH23390	-16595	55	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-SCH23390 Low	-23442	55	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-SCH23390	-23442	55	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-SCH23390	-16595	55	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-SCH23390 Low	-23442	55	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-SCH23390	-23442	55	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-SCH23390	-16595	55	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	1192	147	47	3H-dopamine	-162	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
	1794	147	47	3H-dopamine	-162	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
	CHEMBL501701	147	47	3H-dopamine	-162	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
	1220	187	55	3H-SCH23390	-7943	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-SCH23390	-7943	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-SCH23390	-7943	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-SCH23390	-7943	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	3153	296	28	3H-SCH23390 Low	-39	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	932	296	28	3H-SCH23390 Low	-39	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	CHEMBL26736	296	28	3H-SCH23390 Low	-39	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	179	399	115	3H-SCH23390	-4365	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	179	399	115	3H-SCH23390	-4365	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	399	115	3H-SCH23390	-4365	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	399	115	3H-SCH23390	-4365	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	399	115	3H-SCH23390	-4365	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	399	115	3H-SCH23390	-4365	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	399	115	3H-SCH23390	-4365	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	399	115	3H-SCH23390	-4365	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	399	115	3H-SCH23390	-4365	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	399	115	3H-SCH23390	-4365	51	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2554	793	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
	489	793	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
	5339	793	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
	CHEMBL108	793	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
	DB00564	793	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
	2147	1389	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
	5826	1389	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
	841	1389	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
	CHEMBL612	1389	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
	DB01576	1389	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
	3016	1400	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
	3364	1400	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
	852	1400	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
	CHEMBL12	1400	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
	DB00829	1400	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
	3151	1450	97	3H-SCH23390	-12882	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	945	1450	97	3H-SCH23390	-12882	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	965	1450	97	3H-SCH23390	-12882	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	CHEMBL219916	1450	97	3H-SCH23390	-12882	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	DB01184	1450	97	3H-SCH23390	-12882	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	681	1453	72	3H-SCH23390 Low	-23	39	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	681	1453	72	3H-SCH23390	-97	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-SCH23390 Low	-23	39	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-SCH23390	-97	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-SCH23390 Low	-23	39	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-SCH23390	-97	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-SCH23390 Low	-23	39	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-SCH23390	-97	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-SCH23390 Low	-23	39	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-SCH23390	-97	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	1209	1645	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1645	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1645	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1645	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1645	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	1067	1696	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
	119	1696	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
	1262	1696	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
	5410	1696	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
	6992099	1696	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
	CHEMBL96	1696	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
	DB02530	1696	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
	119376	1828	48	3H-SCH23390	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	247	1828	48	3H-SCH23390	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	CHEMBL33884	1828	48	3H-SCH23390	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	1204	1919	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1919	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1919	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1919	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1919	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1919	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	12575	1975	30	3H-SCH23390	-6606	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	54459	1975	30	3H-SCH23390	-6606	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	CHEMBL10316	1975	30	3H-SCH23390	-6606	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	1427	2000	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	1427	2000	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2000	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2000	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2000	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2000	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2000	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2000	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2000	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2000	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	1567	2299	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	OC(=O)[C@H](Cc1ccc(c(c1)O)O)N	None
	3639	2299	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	OC(=O)[C@H](Cc1ccc(c(c1)O)O)N	None
	6047	2299	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	OC(=O)[C@H](Cc1ccc(c(c1)O)O)N	None
	6971033	2299	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	OC(=O)[C@H](Cc1ccc(c(c1)O)O)N	None
	CHEMBL1009	2299	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	OC(=O)[C@H](Cc1ccc(c(c1)O)O)N	None
	DB01235	2299	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	OC(=O)[C@H](Cc1ccc(c(c1)O)O)N	None
	1310	2303	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
	1369	2303	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
	33032	2303	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
	44272391	2303	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
	88747398	2303	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
	CHEMBL575060	2303	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
	DB00142	2303	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
	18971832	2402	0	3H-SCH23390	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	21	2402	0	3H-SCH23390	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	CHEMBL3186179	2402	0	3H-SCH23390	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	119192	2464	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
	1582	2464	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
	CHEMBL506981	2464	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
	DB06455	2464	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
	1605	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	1728	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	22267	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	4095	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	4586	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	5458	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	643985	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	CHEMBL159659	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	CHEMBL651	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	DB00333	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	DB13515	2481	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C	None
	134	2497	24	3H-SCH23390	-263	68	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-SCH23390	-263	68	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-SCH23390	-263	68	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-SCH23390	-263	68	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-SCH23390	-263	68	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1782	2501	84	3H-SCH23390	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	241	2501	84	3H-SCH23390	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	4168	2501	84	3H-SCH23390	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	CHEMBL86	2501	84	3H-SCH23390	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	DB01233	2501	84	3H-SCH23390	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	1830	2572	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	1830	2572	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2572	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2572	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2572	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2572	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2572	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2572	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2572	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2572	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	1638	2704	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
	1676	2704	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
	1878	2704	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
	5284596	2704	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
	CHEMBL80	2704	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
	DB01183	2704	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
	484	2837	51	3H-SCH23390	-223	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	484	2837	51	3H-SCH23390	-100	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2837	51	3H-SCH23390	-223	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2837	51	3H-SCH23390	-100	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2837	51	3H-SCH23390	-223	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2837	51	3H-SCH23390	-100	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	15897	2840	0	3H-SCH23390	-354	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-SCH23390	-354	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-SCH23390	-354	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	163839	2934	0	3H-SCH23390	-562	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
	268	2934	0	3H-SCH23390	-562	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
	CHEMBL55171	2934	0	3H-SCH23390	-562	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
	2136	3073	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	4768	3073	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	7268	3073	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	CHEMBL753	3073	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	DB00925	3073	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	2142	3074	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	2142	3074	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	2142	3074	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	4920903	3074	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	4920903	3074	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	4920903	3074	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	502	3074	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	502	3074	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	502	3074	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	5775	3074	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	5775	3074	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	5775	3074	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	CHEMBL597	3074	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	CHEMBL597	3074	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	CHEMBL597	3074	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	DB00692	3074	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	DB00692	3074	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	DB00692	3074	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	16362	3103	71	3H-SCH23390	-52480	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3103	71	3H-SCH23390	-52480	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3103	71	3H-SCH23390	-52480	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3103	71	3H-SCH23390	-52480	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3103	71	3H-SCH23390	-52480	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2202	3110	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	4850	3110	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	49	3110	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	CHEMBL1371770	3110	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	DB12478	3110	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	119570	3137	96	3H-SCH23390	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	119570	3137	96	UNDEFINED	-7585	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3137	96	3H-SCH23390	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3137	96	UNDEFINED	-7585	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3137	96	3H-SCH23390	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3137	96	UNDEFINED	-7585	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3137	96	3H-SCH23390	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3137	96	UNDEFINED	-7585	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3137	96	3H-SCH23390	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3137	96	UNDEFINED	-7585	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2286	3161	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	4927	3161	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	7282	3161	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	CHEMBL643	3161	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	DB01069	3161	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	165193	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	165193	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	165193	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	2303	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	2303	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	2303	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	4946	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	4946	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	4946	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	564	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	564	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	564	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	62882	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	62882	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	62882	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	63	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	63	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	63	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	66366	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	66366	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	66366	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	91536	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	91536	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	91536	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	CHEMBL27	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	CHEMBL27	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	CHEMBL27	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	CHEMBL452861	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	CHEMBL452861	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	CHEMBL452861	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	DB00571	3165	68	3H-SCH23390	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	DB00571	3165	68	3H-dopamine	-10000	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	DB00571	3165	68	3H-SCH23390	-10000	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	243	3180	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	3052762	3180	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	3502	3180	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	CHEMBL117287	3180	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	DB06480	3180	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	2	3237	23	3H-SCH23390 Low	-2089	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	2	3237	23	3H-SCH23390	-977	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	54562	3237	23	3H-SCH23390 Low	-2089	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	54562	3237	23	3H-SCH23390	-977	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	CHEMBL240773	3237	23	3H-SCH23390 Low	-2089	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	CHEMBL240773	3237	23	3H-SCH23390	-977	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	173	3238	95	3H-SCH23390	-114	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	3H-SCH23390	-114	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	3H-SCH23390	-114	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	3033769	3256	61	3H-SCH23390	-2754	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	3033769	3256	61	3H-SCH23390	-2754	19	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	3299	3256	61	3H-SCH23390	-2754	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	3299	3256	61	3H-SCH23390	-2754	19	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	94	3256	61	3H-SCH23390	-2754	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	94	3256	61	3H-SCH23390	-2754	19	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	CHEMBL8809	3256	61	3H-SCH23390	-2754	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	CHEMBL8809	3256	61	3H-SCH23390	-2754	19	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	DB12518	3256	61	3H-SCH23390	-2754	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	DB12518	3256	61	3H-SCH23390	-2754	19	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	2389	3306	118	3H-SCH23390	-346	68	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-SCH23390	-346	68	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-SCH23390	-346	68	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-SCH23390	-346	68	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-SCH23390	-346	68	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2402	3345	62	3H-SCH23390	-74	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	5095	3345	62	3H-SCH23390	-74	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	7295	3345	62	3H-SCH23390	-74	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	CHEMBL589	3345	62	3H-SCH23390	-74	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	DB00268	3345	62	3H-SCH23390	-74	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	183782	3373	20	3H-SCH23390	-2398	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
	237	3373	20	3H-SCH23390	-2398	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL85251	3373	20	3H-SCH23390	-2398	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
	128563	3438	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	1666	3438	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	CHEMBL445332	3438	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	DB12327	3438	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	221	3465	71	UNDEFINED	-478	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3465	71	UNDEFINED	-478	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3465	71	UNDEFINED	-478	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	1577	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	1577	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	1577	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	1577	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3677	110	3H-SCH23390	-50	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3677	110	3H-SCH23390	-389	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3677	110	3H-SCH23390	-389	26	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3677	110	3H-SCH23390	-389	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	1267	3775	49	3H-dopamine	-4168	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
	3035905	3775	49	3H-dopamine	-4168	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
	CHEMBL260374	3775	49	3H-dopamine	-4168	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
	102	4096	48	3H-SCH23390	-25118	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-SCH23390	-25118	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-SCH23390	-25118	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-SCH23390	-25118	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-SCH23390	-25118	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	19493	11223	65	3H-SCH23390	-2344	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	133	1	1	1	1.5	N[C@@H]1C[C@H]1c1ccccc1	None
	CHEMBL1179	11223	65	3H-SCH23390	-2344	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	133	1	1	1	1.5	N[C@@H]1C[C@H]1c1ccccc1	None
	CHEMBL1255743	11223	65	3H-SCH23390	-2344	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	133	1	1	1	1.5	N[C@@H]1C[C@H]1c1ccccc1	None
	2662	11352	131	3H-SCH23390	-3	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	CHEMBL118	11352	131	3H-SCH23390	-3	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	10836	14435	14	3H-SCH23390	-147	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
	CHEMBL1201201	14435	14	3H-SCH23390	-147	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
	5090	15529	106	3H-SCH23390	-1348	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	CHEMBL122	15529	106	3H-SCH23390	-1348	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	671690	27066	35	3H-SCH23390	-10	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
	CHEMBL1365455	27066	35	3H-SCH23390	-10	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
	10297	27081	30	3H-SCH23390	-38	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
	CHEMBL136560	27081	30	3H-SCH23390	-38	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
	156391	46770	99	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL1200806	46770	99	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL154	46770	99	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	53321123	58518	0	UNDEFINED	-181	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	0	2	4.2	C#CCOc1cccc2c1-c1cccc3c1C(C2)N(CCC)CC3	None
	CHEMBL1684022	58518	0	UNDEFINED	-181	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	0	2	4.2	C#CCOc1cccc2c1-c1cccc3c1C(C2)N(CCC)CC3	None
	10624	70271	19	3H-SCH23390	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	138543650	70271	19	3H-SCH23390	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	CHEMBL194378	70271	19	3H-SCH23390	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	14659268	79609	2	UNDEFINED	-134	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	None
	CHEMBL2115032	79609	2	UNDEFINED	-134	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	None
	108107	79915	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	156592250	79915	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	CHEMBL1256878	79915	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	CHEMBL212579	79915	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	442108	84607	6	3H-SCH23390	-1	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
	CHEMBL222287	84607	6	3H-SCH23390	-1	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
	54477	84624	36	3H-SCH23390	-138	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	54477	84624	36	UNDEFINED	-138	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	CHEMBL22242	84624	36	3H-SCH23390	-138	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	CHEMBL22242	84624	36	UNDEFINED	-138	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	21830793	91806	10	3H-8-OH-DPAT	-66069	46	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
	CHEMBL2413154	91806	10	3H-8-OH-DPAT	-66069	46	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
	2244	94204	100	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	CHEMBL25	94204	100	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	44448057	94789	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	1	1	2	3.5	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
	CHEMBL253529	94789	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	1	1	2	3.5	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
	44448062	94819	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
	CHEMBL253737	94819	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
	44448066	94846	0	UNDEFINED	-1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	None
	CHEMBL253948	94846	0	UNDEFINED	-1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	None
	44448068	94847	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	4	0	3	5.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(Cc1ccccc1)CC2	None
	CHEMBL253949	94847	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	4	0	3	5.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(Cc1ccccc1)CC2	None
	4528	98098	80	3H-SCH23390	-120	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
	4528	98098	80	3H-SCH23390	-120	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
	CHEMBL273575	98098	80	3H-SCH23390	-120	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
	CHEMBL273575	98098	80	3H-SCH23390	-120	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
	104870	98852	47	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
	5374	98852	47	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
	CHEMBL279085	98852	47	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
	3025067	99354	64	3H-dopamine	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
	65853	99354	64	3H-dopamine	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
	CHEMBL282614	99354	64	3H-dopamine	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
	3663	99939	83	3H-SCH23390	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
	CHEMBL286494	99939	83	3H-SCH23390	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
	127708	112494	7	UNDEFINED	-251	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
	CHEMBL329904	112494	7	UNDEFINED	-251	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
	3452843	119499	15	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
	CHEMBL345686	119499	15	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
	446220	133496	14	3H-SCH23390	-1778	46	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
	CHEMBL370805	133496	14	3H-SCH23390	-1778	46	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
	44208932	140682	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
	CHEMBL381689	140682	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
	9669	153164	2	3H-dopamine	-3890	7	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	2	1	2	3.9	CC(C)=CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@@H]1[C@H]2C	None
	CHEMBL397705	153164	2	3H-dopamine	-3890	7	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	2	1	2	3.9	CC(C)=CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@@H]1[C@H]2C	None
	44448058	155180	0	UNDEFINED	2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
	CHEMBL402517	155180	0	UNDEFINED	2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
	44448065	155456	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
	CHEMBL404037	155456	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
	44448069	155506	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	337	4	0	3	4.2	CCCN1CCc2cc(OC)c(OC)c3c2C1Cc1ccccc1C3	None
	CHEMBL404241	155506	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	337	4	0	3	4.2	CCCN1CCc2cc(OC)c(OC)c3c2C1Cc1ccccc1C3	None
	1615	167767	24	3H-SCH23390	-26	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167767	24	3H-SCH23390	-26	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	4595	176691	106	3H-dopamine	-186	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	CHEMBL46	176691	106	3H-dopamine	-186	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	44581146	176804	0	UNDEFINED	-354	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.5	COc1cccc2cc3n(c12)CCN(CCCCNC(=O)C1=Cc2ccccc2CN1)C3	None
	CHEMBL461023	176804	0	UNDEFINED	-354	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.5	COc1cccc2cc3n(c12)CCN(CCCCNC(=O)C1=Cc2ccccc2CN1)C3	None
	24949694	182746	0	UNDEFINED	-3981	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	6	0	7	3.4	c1cnc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
	CHEMBL479026	182746	0	UNDEFINED	-3981	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	6	0	7	3.4	c1cnc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
	43815	186896	64	3H-SCH23390	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL1708	186896	64	3H-SCH23390	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL490	186896	64	3H-SCH23390	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	11676600	187721	0	UNDEFINED	-1174	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	442	6	0	5	4.4	COc1cccc2cc3n(c12)CCN(CCCCN1CCn2c(cc4ccccc42)C1=O)C3	None
	CHEMBL495573	187721	0	UNDEFINED	-1174	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	442	6	0	5	4.4	COc1cccc2cc3n(c12)CCN(CCCCN1CCn2c(cc4ccccc42)C1=O)C3	None
	11704609	187999	0	UNDEFINED	-2691	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	427	6	0	5	3.6	N#Cc1cccc(N2CCN(CCCCN3CCn4c(cc5ccccc54)C3=O)CC2)c1	None
	CHEMBL497573	187999	0	UNDEFINED	-2691	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	427	6	0	5	3.6	N#Cc1cccc(N2CCN(CCCCN3CCn4c(cc5ccccc54)C3=O)CC2)c1	None
	11596521	188012	0	UNDEFINED	-18620	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	402	7	1	5	3.6	N#Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
	CHEMBL497604	188012	0	UNDEFINED	-18620	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	402	7	1	5	3.6	N#Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
	5280343	188251	124	3H-SCH23390	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL1520590	188251	124	3H-SCH23390	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL50	188251	124	3H-SCH23390	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	44581147	190350	0	UNDEFINED	-1659	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.6	COc1cccc2c1C1CCN(CCCCNC(=O)C3=Cc4ccccc4CN3)CC1=N2	None
	CHEMBL517730	190350	0	UNDEFINED	-1659	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.6	COc1cccc2c1C1CCN(CCCCNC(=O)C3=Cc4ccccc4CN3)CC1=N2	None
	24949388	190504	0	UNDEFINED	-6309	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	6	0	6	3.5	c1ccc(N2CCN(CCCSc3nc4ccccc4o3)CC2)nc1	None
	CHEMBL517962	190504	0	UNDEFINED	-6309	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	6	0	6	3.5	c1ccc(N2CCN(CCCSc3nc4ccccc4o3)CC2)nc1	None
	3672	192509	136	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
	CHEMBL521	192509	136	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
	54676228	193591	112	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
	CHEMBL527	193591	112	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
	2771	194994	74	3H-SCH23390	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	2771	194994	74	3H-SCH23390	-120	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL1200781	194994	74	3H-SCH23390	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL1200781	194994	74	3H-SCH23390	-120	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL549	194994	74	3H-SCH23390	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL549	194994	74	3H-SCH23390	-120	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	4495	196512	92	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	CHEMBL56367	196512	92	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	45112568	198783	0	UNDEFINED	-229	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	None
	CHEMBL583422	198783	0	UNDEFINED	-229	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	None
	54677470	200528	115	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL1256873	200528	115	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL599	200528	115	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	162265	202251	22	3H-SCH23390	-239	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	4786	202251	22	3H-SCH23390	-239	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	CHEMBL61006	202251	22	3H-SCH23390	-239	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	3036864	202731	19	3H-SCH23390	-26	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-SCH23390	-26	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-SCH23390	-26	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-SCH23390	-26	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	5281600	203002	92	3H-SCH23390	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	CHEMBL63354	203002	92	3H-SCH23390	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	5656	203043	87	3H-SCH23390	-25	43	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	CHEMBL637	203043	87	3H-SCH23390	-25	43	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	1973	203460	15	3H-SCH23390	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	CHEMBL1394464	203460	15	3H-SCH23390	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	CHEMBL66089	203460	15	3H-SCH23390	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	1614	203632	24	3H-SCH23390	-81	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
	CHEMBL6731	203632	24	3H-SCH23390	-81	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
	202478	204664	20	3H-SCH23390	-97	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
	CHEMBL7393	204664	20	3H-SCH23390	-97	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
	3821	204695	17	3H-SCH23390	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
	CHEMBL742	204695	17	3H-SCH23390	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
	5311189	204818	11	3H-SCH23390	-194	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
	CHEMBL7549	204818	11	3H-SCH23390	-194	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
	4158	205318	21	3H-SCH23390	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL1722	205318	21	3H-SCH23390	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL796	205318	21	3H-SCH23390	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	4054	205478	72	3H-SCH23390	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL1699	205478	72	3H-SCH23390	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL807	205478	72	3H-SCH23390	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	5324346	205559	59	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
	CHEMBL1409	205559	59	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
	CHEMBL814	205559	59	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
	7108	205735	110	3H-SCH23390	-8	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	199	0	1	2	3.9	c1ccc2c(c1)Nc1ccccc1S2	None
	CHEMBL828	205735	110	3H-SCH23390	-8	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	199	0	1	2	3.9	c1ccc2c(c1)Nc1ccccc1S2	None
	119607	206180	113	3H-SCH23390	-97	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	CHEMBL865	206180	113	3H-SCH23390	-97	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	3337	206344	27	3H-SCH23390	-1513	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-SCH23390	-1513	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-SCH23390	-1513	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-SCH23390	-1513	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-SCH23390	-1513	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	444	206643	53	3H-SCH23390	-2089	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
	CHEMBL894	206643	53	3H-SCH23390	-2089	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
	16231	207486	57	3H-dopamine	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
	CHEMBL945	207486	57	3H-dopamine	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
	12057539	208018	42	3H-SCH23390	-18620	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-SCH23390	-18620	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-SCH23390	-18620	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	6852400	215914	0	3H-dopamine	-14125	22	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	6852400	215914	0	3H-SCH23390	-25118	22	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	6852400	215914	0	3H-SCH23390	-25118	22	Rhesus macaque	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	215914	0	3H-dopamine	-14125	22	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	215914	0	3H-SCH23390	-25118	22	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	215914	0	3H-SCH23390	-25118	22	Rhesus macaque	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	57174031	215917	0	3H-SCH23390	-1778	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
	None	215920	0	3H-dopamine	-7943	11	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	11954224	215928	0	3H-SCH23390	-3467	60	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	3246155	215937	0	3H-dopamine	-43651	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
	11954259	215954	0	3H-dopamine	-7762	44	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	57525649	215965	0	3H-SCH23390	-1	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	187	4	0	1	2.2	CC(CC1=CC=CC=C1)N(C)CC#C	None
	44134711	215966	0	3H-SCH23390	-112201	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	340	6	2	4	2.8	CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl	None
	None	215967	0	3H-SCH23390	-1071	11	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.2	C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl	None
	None	215968	0	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
	6420041	215969	0	3H-SCH23390	-14	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	4	0	2	3.8	CN(C)CC=C(C1=CC=C(C=C1)Br)C2=CN=CC=C2	None
	104911	215994	0	3H-SCH23390	-41686	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
	None	216001	0	3H-SCH23390	-6309	14	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	453	9	2	6	2.6	COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl	None
	131632304	216011	0	3H-SCH23390	-70794	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	119380	216103	0	125I-SCH 23982	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	166	1	0	3	1.8	CC1=NOC(=C1)C2CCCN2C	None
	None	216109	0	3H-SCH23390	-10471	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
	25137849	216153	0	3H-SCH23390	-4	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	71290	216153	0	3H-SCH23390	-4	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	None	216208	0	3H-SCH23390	-13	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	2	1	2	2.4	CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl	None
	None	216213	0	3H-SCH23390	-95499	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
	None	216228	0	3H-dopamine	-8317	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
	5372683	216260	0	3H-dopamine	-1479	3	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	400	5	1	4	4.2	C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO	None
	None	216285	0	3H-SCH23390	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
	None	216286	0	3H-SCH23390	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
	None	216287	0	3H-SCH23390	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
	None	216288	0	3H-SCH23390	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
	None	216289	0	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
	None	216290	0	3H-SCH23390	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
	None	216291	0	3H-SCH23390	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
	None	216292	0	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
	None	216299	0	3H-SCH23390	-13	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
	1576	216300	0	3H-SCH23390	-16	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
	4978	216302	0	3H-SCH23390	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
	None	216303	0	3H-SCH23390	-3	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
	None	216304	0	3H-SCH23390	-281	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
	None	216305	0	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
	None	216316	0	3H-SCH23390	-1862	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	246	2	1	4	1.6	CCCN1CCCC2C1CC3=CN=C(N=C3C2)N	None
	135269	216363	0	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
	23681059	216364	0	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
	5018304	216365	0	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
	84003	216366	0	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
	123619	216367	0	3H-SCH23390	-1412	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
	119828	216368	0	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
	None	216369	0	3H-SCH23390	-7	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
	None	216423	0	UNDEFINED	-660	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	None	216423	0	UNDEFINED	-660	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	None	216462	0	3H-SCH23390	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
	None	216467	0	3H-SCH23390	-1	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	399	7	4	5	1.8	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O	None
	None	216540	0	UNDEFINED	-549	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
	None	216693	0	UNDEFINED	-3090	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	251	0	2	2	3.1	CC1=C(C2=C(CC3C4=C2C=CC=C4CCN3)C=C1)O	None
	None	216695	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	601	23	0	3	11.9	CCCCCCCCCCCCCCCCCCCCCC(=O)OC1=CC=CC2=C1C3=C4C(C2)N(CCC4=CC=C3)CCC	None
	None	216696	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	363	6	0	3	5.3	CCCCC(=O)OC1=CC=CC2=C1C3=C4C(C2)N(CCC4=CC=C3)CCC	None
	None	216697	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	321	3	0	3	4.1	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OC(=O)C	None
	None	216705	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	4.1	CCCN1CCC2=C3C1CC4=C(C=CC(=C4)O)OC3=CC=C2	None
	None	216706	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	4.1	CCCN1CCC2=CC(=CC3=C2C1CC4=CC=CC=C4O3)O	None
	None	216745	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	323	4	1	3	4.3	CCCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
	None	217133	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	436	9	2	5	4.7	CCCN(CCCCNC(=O)C1=CC2=CC=CC=C2C=C1)C3CCC4=C(C3)SC(=N4)N	None
	None	217245	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	4	0	4	4.2	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)OC(=O)C	None
	None	217246	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	0	4	5.3	CCCCC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)CCC)OC	None
	None	217488	0	UNDEFINED	-1023	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	291	0	0	2	3.8	CC1CC2=C(O1)C3=C(CC4C5=C3C=CC=C5CCN4C)C=C2	None
	None	217489	0	UNDEFINED	-69	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	321	3	1	3	3.9	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=C(C=C4)CC=C)O	None
	None	217490	0	UNDEFINED	-151	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	321	4	0	3	4.0	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)OCC=C	None
	None	217491	0	UNDEFINED	-346	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	0	0	2	4.5	CC1=CC2=C(O1)C3=C(CC4C5=C3C=CC=C5CCN4C)C=C2	None
	None	217492	0	UNDEFINED	-707	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	2	0	2	3.5	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC#C	None
	None	217493	0	UNDEFINED	-74	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	291	2	1	2	3.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)CC=C)O	None
	None	217494	0	UNDEFINED	-831	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	291	3	0	2	4.0	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C	None
	None	217495	0	UNDEFINED	-19	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	0	2	5.6	CCCN1CCC2=CC=CC3=C2C1CC4=C3C5=C(C=C4)C(=C(O5)C)C	None
	None	217496	0	UNDEFINED	-30	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	2	0	2	5.3	CCCN1CCC2=CC=CC3=C2C1CC4=C3C5=C(C=C4)C=C(O5)C	None
	None	217497	0	UNDEFINED	-79	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	2	4.6	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC#CC	None
	None	217498	0	UNDEFINED	-15	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	333	2	0	2	4.9	CCCN1CCC2=CC=CC3=C2C1CC4=C3C5=C(CC(O5)(C)C)C=C4	None
	None	217499	0	UNDEFINED	-12	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	4	1	2	4.7	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)CC=C)O	None
	None	217500	0	UNDEFINED	-67	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	5	0	2	5.6	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C(C)C	None
	None	217501	0	UNDEFINED	-26	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	333	5	0	2	5.2	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC(=C)C	None
	None	217502	0	UNDEFINED	-35	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	5	0	2	4.8	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C	None
	None	217510	0	UNDEFINED	1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	4	1	2	5.4	CCCN1CCC2=CC=CC3=C2C1CC4=C(C=CC(=C43)O)CC=C(C)C	None
	None	217511	0	UNDEFINED	1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	333	4	1	2	5.0	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)CC(=C)C)O	None
	1524	2168	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	25058166	215935	0	UNDEFINED	-147	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	UNDEFINED	-147	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	126968774	215964	0	3H-dopamine	-42	8	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O	None
	1242	3586	27	3H-SCH23390	-6	18	Rhesus macaque	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	3H-SCH23390	-6	18	Rhesus macaque	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	3H-SCH23390	-6	18	Rhesus macaque	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	1353	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	45112462	196943	0	UNDEFINED	-831	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	None
	CHEMBL566533	196943	0	UNDEFINED	-831	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	None
	25058166	215935	0	3H-SCH23390 Low	-6	27	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-SCH23390 Low	-6	27	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	3153	296	28	3H-dopamine	-39	8	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	932	296	28	3H-dopamine	-39	8	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	CHEMBL26736	296	28	3H-dopamine	-39	8	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	1212	1649	50	3H-SCH23390	-14	66	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-SCH23390	-14	66	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-SCH23390	-14	66	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-SCH23390	-14	66	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-SCH23390	-14	66	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	681	1453	72	3H-dopamine	-23	39	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-dopamine	-23	39	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-dopamine	-23	39	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-dopamine	-23	39	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-dopamine	-23	39	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	1353	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	None	216692	0	UNDEFINED	-190	2	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	237	0	2	2	2.8	C1CNC2CC3=C(C4=C2C1=CC=C4)C(=CC=C3)O	None
	2726	916	68	3H-SCH23390	-36	73	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-SCH23390	-36	73	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-SCH23390	-36	73	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-SCH23390	-36	73	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-SCH23390	-36	73	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	1218	3589	30	3H-SCH23390	-11	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
	938	3589	30	3H-SCH23390	-11	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
	CHEMBL353335	3589	30	3H-SCH23390	-11	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
	2726	916	68	3H-SCH23390	-186	73	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-SCH23390	-186	73	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-SCH23390	-186	73	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-SCH23390	-186	73	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-SCH23390	-186	73	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	None	216932	0	UNDEFINED	1	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	365	5	0	4	4.5	CCCCC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)C)OC	None
	277	1289	62	3H-SCH23390	-47	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-SCH23390	-47	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-SCH23390	-47	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-SCH23390	-47	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-SCH23390	-47	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	1353	1898	93	3H-SCH233930	-38	86	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH233930	-38	86	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH233930	-38	86	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH233930	-38	86	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH233930	-38	86	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	135398745	2893	112	3H-SCH23390	-26	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-SCH23390	-26	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-SCH23390	-26	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-SCH23390	-26	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2893	112	UNDEFINED	-26	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	UNDEFINED	-26	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	UNDEFINED	-26	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	UNDEFINED	-26	66	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2435	3563	83	UNDEFINED	-43	49	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	UNDEFINED	-43	49	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	UNDEFINED	-43	49	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	UNDEFINED	-43	49	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	UNDEFINED	-43	49	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	1353	1898	93	UNDEFINED	-38	86	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	UNDEFINED	-38	86	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	UNDEFINED	-38	86	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	UNDEFINED	-38	86	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	UNDEFINED	-38	86	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	277	1289	62	3H-dopamine	-1445	46	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-dopamine	-1445	46	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-dopamine	-1445	46	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-dopamine	-1445	46	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-dopamine	-1445	46	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	4508	3117	98	3H-dopamine	-239	13	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
	4866774	3117	98	3H-dopamine	-239	13	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
	509	3117	98	3H-dopamine	-239	13	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
	838	3117	98	3H-dopamine	-239	13	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
	CHEMBL1740	3117	98	3H-dopamine	-239	13	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
	4249	78150	34	3H-dopamine	-1230	6	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	355	6	1	3	4.1	Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	None
	CHEMBL2104700	78150	34	3H-dopamine	-1230	6	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	355	6	1	3	4.1	Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	None
	681	1453	72	UNDEFINED	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	UNDEFINED	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	UNDEFINED	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	UNDEFINED	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	UNDEFINED	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	None	217338	0	UNDEFINED	-	1	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	409	2	3	4	5.0	CCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=C(C=C5)O.Cl	None
	2337	3232	77	3H-SCH23390	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-SCH23390	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-SCH23390	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-SCH23390	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-SCH23390	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	24949690	181582	0	UNDEFINED	-1819	3	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	None
	CHEMBL477200	181582	0	UNDEFINED	-1819	3	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	None
	2337	3232	77	3H-SCH233930	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-SCH233930	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-SCH233930	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-SCH233930	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-SCH233930	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	681	1453	72	125I-SCH 23982	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	125I-SCH 23982	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	125I-SCH 23982	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	125I-SCH 23982	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	125I-SCH 23982	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	2865	4112	73	UNDEFINED	-114	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	UNDEFINED	-114	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	UNDEFINED	-114	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	UNDEFINED	-114	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	UNDEFINED	-114	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	None	216747	0	UNDEFINED	-	1	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	3.5	CCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
	2337	3232	77	UNDEFINED	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	UNDEFINED	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	UNDEFINED	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	UNDEFINED	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	UNDEFINED	-53	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2865	4112	73	3H-SCH233930	-114	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-SCH233930	-114	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-SCH233930	-114	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-SCH233930	-114	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-SCH233930	-114	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	None	217336	0	UNDEFINED	-	1	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	331	1	2	3	4.0	CCN1CCC2=C3C1CC4=C(C3=CC(=C2)C)C(=C(C=C4)O)O.Cl	None
	1242	3586	27	3H-SCH23390 Low	-11	18	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	3H-SCH23390 Low	-11	18	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	3H-SCH23390 Low	-11	18	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	2105	3032	37	3H-SCH23390	-537	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	3H-SCH23390	-537	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	3H-SCH23390	-537	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	3H-SCH23390	-537	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	3H-SCH23390	-537	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	135409468	2022	69	3H-SCH23390	-12	40	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	333	2022	69	3H-SCH23390	-12	40	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	CHEMBL845	2022	69	3H-SCH23390	-12	40	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	37459	743	13	3H-SCH23390	-8	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-SCH23390	-8	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-SCH23390	-8	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	1222	1651	49	3H-dopamine	-2344	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3396	1651	49	3H-dopamine	-2344	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	85	1651	49	3H-dopamine	-2344	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL46516	1651	49	3H-dopamine	-2344	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	DB04842	1651	49	3H-dopamine	-2344	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2470	3626	50	3H-dopamine	-31622	60	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-dopamine	-31622	60	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-dopamine	-31622	60	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-dopamine	-31622	60	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-dopamine	-31622	60	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	135398737	955	93	3H-SCH23390	-44	92	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-44	92	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-44	92	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-44	92	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-44	92	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	127708	112494	7	UNDEFINED	-22	5	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
	CHEMBL329904	112494	7	UNDEFINED	-22	5	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
	135	2515	43	3H-SCH23390	-91	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-SCH23390	-91	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-SCH23390	-91	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-SCH23390	-91	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-SCH23390	-91	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	16362	3103	71	3H-SCH23390	-7413	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3103	71	3H-SCH23390	-7413	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3103	71	3H-SCH23390	-7413	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3103	71	3H-SCH23390	-7413	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3103	71	3H-SCH23390	-7413	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	681	1453	72	3H-SCH23390	-97	39	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-SCH23390	-97	39	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-SCH23390	-97	39	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-SCH23390	-97	39	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-SCH23390	-97	39	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	2389	3306	118	3H-SCH23390	-489	68	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-SCH23390	-489	68	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-SCH23390	-489	68	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-SCH23390	-489	68	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-SCH23390	-489	68	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	None	216932	0	UNDEFINED	-12	3	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	365	5	0	4	4.5	CCCCC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)C)OC	None
	1353	1898	93	UNDEFINED	-74	86	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	UNDEFINED	-74	86	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	UNDEFINED	-74	86	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	UNDEFINED	-74	86	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	UNDEFINED	-74	86	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	None	216708	0	UNDEFINED	-	1	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	419	3	1	5	3.9	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)O)Br	None
	1242	3586	27	3H-SCH23390	-5	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	3H-SCH23390	-5	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	3H-SCH23390	-5	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	1890	2739	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
	4449	2739	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
	7247	2739	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
	CHEMBL623	2739	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
	DB01149	2739	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
	11954259	215954	0	3H-SCH23390	-5011	44	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	71299720	215926	0	3H-SCH23390	-1202	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
	1353	1898	93	3H-SCH23390	-107	86	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-107	86	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-107	86	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-107	86	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-107	86	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	134	2497	24	3H-SCH23390	-575	68	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-SCH23390	-575	68	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-SCH23390	-575	68	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-SCH23390	-575	68	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-SCH23390	-575	68	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1613	2333	53	3H-SCH23390	-4	45	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-SCH23390	-4	45	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-SCH23390	-4	45	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-SCH23390	-4	45	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-SCH23390	-4	45	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	681	1453	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	33630	178933	99	3H-dopamine	-281	28	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL47050	178933	99	3H-dopamine	-281	28	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	24949534	189494	0	UNDEFINED	-2041	3	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	None
	CHEMBL514074	189494	0	UNDEFINED	-2041	3	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	None
	11653679	181167	1	UNDEFINED	-24	11	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL476108	181167	1	UNDEFINED	-24	11	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
	None	216746	0	UNDEFINED	-	1	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	309	3	1	3	3.9	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
	5018	3523	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	943	3523	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	946	3523	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	CHEMBL13668	3523	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	172286	216361	0	3H-SCH23390	1	2	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	331	0	0	4	3.6	CN1CCN(CC1)C2=NC3=C(CC4=C2C=CS4)C=CC(=C3)Cl	None
	681	1453	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	None	216356	0	3H-SCH23390	165	2	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	1	1	3	4.4	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OC=C4)O)Cl	None
	None	216699	0	UNDEFINED	-	1	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	343	1	2	3	4.5	CN1CCC2=CC(=CC3=C2C1CC4=C3C(=CC=C4)O)C5=CC=C(C=C5)O	None
	15443	117784	96	3H-dopamine	-257	10	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	None
	CHEMBL340211	117784	96	3H-dopamine	-257	10	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	None
	5018	3523	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	943	3523	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	946	3523	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	CHEMBL13668	3523	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	3036864	202731	19	125I-Spectramide	-2	28	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	125I-Spectramide	-2	28	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	125I-Spectramide	-2	28	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	125I-Spectramide	-2	28	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	2286	3161	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	4927	3161	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	7282	3161	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	CHEMBL643	3161	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	DB01069	3161	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	100	3776	58	3H-dopamine	-309	56	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-dopamine	-309	56	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-dopamine	-309	56	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-dopamine	-309	56	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-dopamine	-309	56	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	1212	1649	50	UNDEFINED	-51	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	UNDEFINED	-51	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	UNDEFINED	-51	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	UNDEFINED	-51	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	UNDEFINED	-51	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	11976	917	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	917	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	917	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	917	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	1212	1649	50	3H-SCH23390	-288	66	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-SCH23390	-288	66	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-SCH23390	-288	66	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-SCH23390	-288	66	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-SCH23390	-288	66	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1242	3586	27	3H-SCH23390	-1	18	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	1242	3586	27	3H-SCH23390	1	18	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	3H-SCH23390	-1	18	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	3H-SCH23390	1	18	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	3H-SCH23390	-1	18	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	3H-SCH23390	1	18	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	5281878	1647	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1212	1649	50	3H-dopamine	-288	66	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-dopamine	-288	66	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-dopamine	-288	66	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-dopamine	-288	66	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-dopamine	-288	66	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1621	2413	17	3H-SCH23390	-588	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-SCH23390	-588	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-SCH23390	-588	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-SCH23390	-588	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-SCH23390	-588	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	None	216256	0	3H-dopamine	2	2	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	267	1	2	2	1.5	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)N	None
	100	3776	58	3H-dopamine	-309	56	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-dopamine	-309	56	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-dopamine	-309	56	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-dopamine	-309	56	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-dopamine	-309	56	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	None	216703	0	UNDEFINED	-	1	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	325	3	2	4	3.6	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=C(C=C4)O)O	None
	100	3776	58	3H-dopamine	-309	56	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-dopamine	-309	56	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-dopamine	-309	56	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-dopamine	-309	56	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-dopamine	-309	56	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	30137	2857	0	3H-SCH23390	-676	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	8594	2857	0	3H-SCH23390	-676	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	934	2857	0	3H-SCH23390	-676	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	1153	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	12668023	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	30026874	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	30026875	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	3341	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	6603851	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	933	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	939	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	985	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL1160786	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL1161520	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL588	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	DB00800	1615	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	None	216344	0	3H-SCH23390	-11220	2	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	487	8	2	4	3.9	CNC1=C(C=C(C(=C1)OC)C(=O)NCCN(C)CC2=CC=C(C=C2)I)Cl	None
	135398737	955	93	3H-SCH23390	-44	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-44	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-44	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-44	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-44	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	3H-dopamine	-204	92	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-dopamine	-204	92	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-dopamine	-204	92	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-dopamine	-204	92	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-dopamine	-204	92	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1524	2168	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	None	216258	0	3H-dopamine	-741	2	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	454	6	1	4	4.8	C1CN(CCN1CCCC2C3=C(C=C(C=C3)F)SC4=C2C=C(C=C4)C(F)(F)F)CCO	None
	135398737	955	93	3H-SCH23390	-44	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-44	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-44	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-44	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-44	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	242	469	124	3H-SCH23390	-281	52	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	242	469	124	UNDEFINED	-74	52	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-SCH23390	-281	52	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	UNDEFINED	-74	52	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-SCH23390	-281	52	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	UNDEFINED	-74	52	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-SCH23390	-281	52	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	UNDEFINED	-74	52	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-SCH23390	-281	52	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	UNDEFINED	-74	52	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	4106	2485	22	3H-SCH23390	-5	34	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-SCH23390	-5	34	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-SCH23390	-5	34	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-SCH23390	-5	34	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	None	216711	0	UNDEFINED	-	1	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	453	2	2	5	3.5	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O)I	None
	37459	743	13	3H-SCH23390	-53	25	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-SCH23390	-53	25	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-SCH23390	-53	25	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	6603820	95745	19	3H-SCH23390	1	13	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	CHEMBL25856	95745	19	3H-SCH23390	1	13	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	1238	203151	24	3H-SCH23390	-5	17	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL64249	203151	24	3H-SCH23390	-5	17	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	3153	296	28	3H-SCH23390 High	-39	8	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	932	296	28	3H-SCH23390 High	-39	8	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	CHEMBL26736	296	28	3H-SCH23390 High	-39	8	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	46780481	107504	20	3H-SCH23390	-29	54	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107504	20	3H-SCH23390	-29	54	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107504	20	3H-SCH23390	-29	54	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107504	20	3H-SCH23390	-29	54	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	20840341	216151	0	3H-SCH23390	-3	4	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	451	5	1	3	6.2	C1CN(CCC1CCO)CCC=C2C3=C(C=C(C=C3)F)SC4=C2C=C(C=C4)C(F)(F)F	None
	6603820	95745	19	3H-SCH23390	-2	13	Rhesus macaque	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	CHEMBL25856	95745	19	3H-SCH23390	-2	13	Rhesus macaque	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	1524	2168	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	484	2837	51	3H-dopamine	-4	36	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2837	51	3H-dopamine	-4	36	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2837	51	3H-dopamine	-4	36	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	None	216694	0	UNDEFINED	-165	2	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	293	2	1	2	4.2	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)C)O	None
	24949857	181743	0	UNDEFINED	-7413	3	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	None
	CHEMBL477765	181743	0	UNDEFINED	-7413	3	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	None
	25212275	174397	0	UNDEFINED	-4897	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	None
	CHEMBL455288	174397	0	UNDEFINED	-4897	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	None
	25212276	190042	0	UNDEFINED	-575	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	None
	CHEMBL517244	190042	0	UNDEFINED	-575	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	None
	3151	1450	97	3H-SCH23390	-2630	27	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	945	1450	97	3H-SCH23390	-2630	27	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	965	1450	97	3H-SCH23390	-2630	27	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	CHEMBL219916	1450	97	3H-SCH23390	-2630	27	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	DB01184	1450	97	3H-SCH23390	-2630	27	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	135398737	955	93	3H-dopamine	-204	92	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-dopamine	-204	92	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-dopamine	-204	92	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-dopamine	-204	92	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-dopamine	-204	92	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	126968774	215964	0	3H-SCH23390	-831	8	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O	None
	5475158	67183	25	3H-SCH23390	-489	14	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
	CHEMBL18786	67183	25	3H-SCH23390	-489	14	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
	1212	1649	50	3H-SCH23390	-51	66	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-SCH23390	-51	66	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-SCH23390	-51	66	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-SCH23390	-51	66	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-SCH23390	-51	66	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2389	3306	118	UNDEFINED	-346	68	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	UNDEFINED	-346	68	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	UNDEFINED	-346	68	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	UNDEFINED	-346	68	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	UNDEFINED	-346	68	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	100	3776	58	3H-SCH23390	-16	56	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-SCH23390	-16	56	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-SCH23390	-16	56	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-SCH23390	-16	56	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-SCH23390	-16	56	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	6603820	95745	19	3H-SCH23390	-4	13	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	CHEMBL25856	95745	19	3H-SCH23390	-4	13	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	None	216359	0	125I-SCH 23982	74	2	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	365	2	3	4	3.7	C1C2CC3CC1CC(C2)(C3)C4CC5=C(C=CC(=C5O)O)C(O4)CN.Cl	None
	4106	2485	22	3H-dopamine	-524	34	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-dopamine	-524	34	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-dopamine	-524	34	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-dopamine	-524	34	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	2435	3563	83	3H-SCH23390	-43	49	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	3H-SCH23390	-43	49	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	3H-SCH23390	-43	49	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	3H-SCH23390	-43	49	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	3H-SCH23390	-43	49	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	25058166	215935	0	UNDEFINED	-147	27	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	UNDEFINED	-147	27	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	None	216709	0	UNDEFINED	-	1	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	481	4	0	5	4.1	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC)I	None
	None	216315	0	3H-SCH23390	-281	19	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	451	8	2	4	3.2	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C	None
	3294	1993	111	3H-SCH23390	-56	45	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	3H-SCH23390	-56	45	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	3H-SCH23390	-56	45	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	3H-SCH23390	-56	45	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	3H-SCH23390	-56	45	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	134	2497	24	3H-SCH23390	-186	68	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-SCH23390	-186	68	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-SCH23390	-186	68	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-SCH23390	-186	68	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-SCH23390	-186	68	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	None	216207	0	3H-SCH23390	-3090	3	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	315	6	1	3	4.3	CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O	None
	2398	951	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	2801	951	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	701	951	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	CHEMBL415	951	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	DB01242	951	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	10742	3590	31	3H-SCH23390	-2	8	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
	1225	3590	31	3H-SCH23390	-2	8	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
	CHEMBL35354	3590	31	3H-SCH23390	-2	8	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
	2470	3626	50	3H-SCH23390	-4168	60	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-SCH23390	-4168	60	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-SCH23390	-4168	60	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-SCH23390	-4168	60	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-SCH23390	-4168	60	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	4382	104753	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
	86470	104753	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
	CHEMBL1256484	104753	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
	CHEMBL31088	104753	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
	1212	1649	50	3H-dopamine	-288	66	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-dopamine	-288	66	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-dopamine	-288	66	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-dopamine	-288	66	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-dopamine	-288	66	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2389	3306	118	3H-SCH23390	-346	68	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-SCH23390	-346	68	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-SCH23390	-346	68	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-SCH23390	-346	68	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-SCH23390	-346	68	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	44591134	176176	0	UNDEFINED	-194	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
	CHEMBL459373	176176	0	UNDEFINED	-194	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
	681	1453	72	3H-SCH23390	-154	39	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-SCH23390	-154	39	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-SCH23390	-154	39	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-SCH23390	-154	39	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-SCH23390	-154	39	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	1212	1649	50	3H-SCH23390	-51	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-SCH23390	-51	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-SCH23390	-51	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-SCH23390	-51	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-SCH23390	-51	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	46780481	107504	20	3H-SCH23390	-64	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107504	20	3H-SCH23390	-64	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107504	20	3H-SCH23390	-64	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107504	20	3H-SCH23390	-64	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	None	216700	0	UNDEFINED	-	1	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	341	3	1	5	3.2	CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)O	None
	1212	1649	50	3H-dopamine	-288	66	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-dopamine	-288	66	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-dopamine	-288	66	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-dopamine	-288	66	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-dopamine	-288	66	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2181	3106	46	3H-SCH23390	-2041	35	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	4830	3106	46	3H-SCH23390	-2041	35	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	92	3106	46	3H-SCH23390	-2041	35	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	CHEMBL440294	3106	46	3H-SCH23390	-2041	35	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	DB09286	3106	46	3H-SCH23390	-2041	35	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	None	217134	0	UNDEFINED	-158	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	532	10	0	4	8.0	CN(CCC=C1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)CC4=CC=C(C=C4)OCCCN5CCCCC5	None
	2726	916	68	3H-SCH23390	-14	73	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	2726	916	68	3H-SCH23390	-18	73	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-SCH23390	-14	73	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-SCH23390	-18	73	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-SCH23390	-14	73	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-SCH23390	-18	73	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-SCH23390	-14	73	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-SCH23390	-18	73	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-SCH23390	-14	73	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-SCH23390	-18	73	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	135398745	2893	112	3H-SCH23390	-26	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2893	112	UNDEFINED	-23	66	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-SCH23390	-26	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	UNDEFINED	-23	66	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-SCH23390	-26	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	UNDEFINED	-23	66	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-SCH23390	-26	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	UNDEFINED	-23	66	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	11976	917	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	917	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	917	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	917	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	135398745	2893	112	3H-SCH23390	-23	66	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-SCH23390	-23	66	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-SCH23390	-23	66	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-SCH23390	-23	66	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135	2515	43	3H-dopamine	-457	58	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-dopamine	-457	58	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-dopamine	-457	58	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-dopamine	-457	58	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-dopamine	-457	58	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	None	216933	0	UNDEFINED	-7	2	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	339	0	3	6	3.0	CN1CCC2=C3C1CC4=C(C3=CC5=C2SC(=N5)N)C(=C(C=C4)O)O	None
	None	216749	0	UNDEFINED	1	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	251	0	1	2	3.1	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)O	None
	1242	3586	27	3H-SCH23390	1	18	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	3H-SCH23390	1	18	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	3H-SCH23390	1	18	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	73333	5931	31	UNDEFINED	-16	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL1079935	5931	31	UNDEFINED	-16	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	4452	2742	19	3H-SCH23390	-89125	19	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	983	2742	19	3H-SCH23390	-89125	19	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	CHEMBL20734	2742	19	3H-SCH23390	-89125	19	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	2337	3232	77	3H-SCH23390	-134	63	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-SCH23390	-134	63	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-SCH23390	-134	63	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-SCH23390	-134	63	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-SCH23390	-134	63	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	135398737	955	93	3H-SCH23390	-37	92	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-37	92	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-37	92	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-37	92	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-37	92	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	2389	3306	118	3H-SCH23390	-489	68	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-SCH23390	-489	68	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-SCH23390	-489	68	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-SCH23390	-489	68	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-SCH23390	-489	68	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	1353	1898	93	3H-SCH23390	-30	86	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-30	86	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-30	86	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-30	86	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-30	86	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1898	93	3H-SCH23390	-38	86	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-38	86	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-38	86	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-38	86	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-38	86	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	None	216691	0	UNDEFINED	-60	2	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	263	1	0	1	4.0	CCC1=CC=CC2=C1C3=C4C(C2)N(CCC4=CC=C3)C	None
	None	215915	0	3H-SCH23390	-45708	21	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	None	217339	0	UNDEFINED	-	1	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	345	2	2	3	4.4	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)C)C(=C(C=C4)O)O.Cl	None
	1153	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	12668023	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	30026874	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	30026875	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	3341	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	6603851	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	933	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	939	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	985	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL1160786	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL1161520	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL588	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	DB00800	1615	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	2601	3751	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3751	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3751	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3751	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3751	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1028	289	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	139148732	289	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	479	289	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	5816	289	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	CHEMBL679	289	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	DB00668	289	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	135398737	955	93	3H-dopamine	-204	92	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-dopamine	-204	92	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-dopamine	-204	92	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-dopamine	-204	92	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-dopamine	-204	92	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	125564	663	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
	388	663	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
	7670	663	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
	CHEMBL178803	663	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
	DB09223	663	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
	135398737	955	93	3H-SCH233930	-44	92	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH233930	-44	92	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH233930	-44	92	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH233930	-44	92	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH233930	-44	92	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	209	3035	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	3035	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	3035	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	3035	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	3035	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	135398737	955	93	UNDEFINED	-44	92	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	UNDEFINED	-44	92	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	UNDEFINED	-44	92	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	UNDEFINED	-44	92	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	UNDEFINED	-44	92	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	134	2497	24	3H-dopamine	-575	68	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-dopamine	-575	68	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-dopamine	-575	68	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-dopamine	-575	68	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-dopamine	-575	68	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	25058166	215935	0	UNDEFINED	-144	27	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	UNDEFINED	-144	27	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	None	216702	0	UNDEFINED	-	1	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.9	CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O	None
	10145	216701	0	UNDEFINED	-	1	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	355	4	0	5	3.5	CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC	None
	None	216930	0	UNDEFINED	-1	2	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	265	0	2	3	2.6	CN1CCC2=C3C1CC4=C(C3=CC(=C2)N)C(=CC=C4)N	None
	185	3975	60	3H-SCH23390	-6606	38	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	5311271	3975	60	3H-SCH23390	-6606	38	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	CHEMBL74355	3975	60	3H-SCH23390	-6606	38	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	DB16351	3975	60	3H-SCH23390	-6606	38	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	122324	205	22	125I-SCH 23982	323	3	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	None
	6077	205	22	125I-SCH 23982	323	3	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	None
	CHEMBL86931	205	22	125I-SCH 23982	323	3	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	None
	37459	743	13	3H-SCH23390	-10	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-SCH23390	-10	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-SCH23390	-10	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	5281878	1647	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281878	1647	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	9861622	199421	5	3H-SCH23390	1202	2	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	None
	CHEMBL59139	199421	5	3H-SCH23390	1202	2	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	None
	62865	1263	0	3H-SCH23390	-2	15	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	746	1263	0	3H-SCH23390	-2	15	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	84	1263	0	3H-SCH23390	-2	15	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	CHEMBL2104153	1263	0	3H-SCH23390	-2	15	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	DB09000	1263	0	3H-SCH23390	-2	15	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	1621	2413	17	3H-dopamine	-97	45	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-dopamine	-97	45	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-dopamine	-97	45	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-dopamine	-97	45	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-dopamine	-97	45	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2865	4112	73	3H-SCH23390	-114	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-SCH23390	-114	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-SCH23390	-114	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-SCH23390	-114	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-SCH23390	-114	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	11954224	215928	0	3H-dopamine	-426	60	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	1242	3586	27	3H-SCH23390 High	-11	18	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	3H-SCH23390 High	-11	18	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	3H-SCH23390 High	-11	18	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	1427	2000	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2000	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2000	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2000	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2000	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	10333195	48156	0	UNDEFINED	-10	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
	CHEMBL155208	48156	0	UNDEFINED	-10	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
	44591099	176166	0	UNDEFINED	-1122	6	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
	CHEMBL459350	176166	0	UNDEFINED	-1122	6	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
	135398745	2893	112	3H-SCH23390	-23	66	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-SCH23390	-23	66	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-SCH23390	-23	66	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-SCH23390	-23	66	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	None	217337	0	UNDEFINED	-	1	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	393	2	2	3	5.3	CCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5.Cl	None
	1353	1898	93	3H-SCH23390	-512	86	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-512	86	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-512	86	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-512	86	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-512	86	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1898	93	UNDEFINED	-74	86	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	UNDEFINED	-74	86	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	UNDEFINED	-74	86	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	UNDEFINED	-74	86	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	UNDEFINED	-74	86	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	135	2515	43	3H-SCH23390	-457	58	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-SCH23390	-457	58	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-SCH23390	-457	58	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-SCH23390	-457	58	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-SCH23390	-457	58	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	6852400	215914	0	3H-SCH23390	-14125	22	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	215914	0	3H-SCH23390	-14125	22	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	186	1794	52	3H-SCH23390	-53	17	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	71781	1794	52	3H-SCH23390	-53	17	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	CHEMBL18972	1794	52	3H-SCH23390	-53	17	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	11696813	187894	12	UNDEFINED	-316	9	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
	CHEMBL496739	187894	12	UNDEFINED	-316	9	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
	6603820	95745	19	125I-SCH 23982	-4	13	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	CHEMBL25856	95745	19	125I-SCH 23982	-4	13	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	2865	4112	73	3H-SCH23390	-114	54	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-SCH23390	-114	54	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-SCH23390	-114	54	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-SCH23390	-114	54	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-SCH23390	-114	54	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	2105	3032	37	3H-SCH23390	-537	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	3H-SCH23390	-537	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	3H-SCH23390	-537	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	3H-SCH23390	-537	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	3H-SCH23390	-537	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	1212	1649	50	3H-dopamine	-288	66	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-dopamine	-288	66	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-dopamine	-288	66	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-dopamine	-288	66	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-dopamine	-288	66	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	None	216540	0	UNDEFINED	-549	6	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
	30137	2857	0	UNDEFINED	-3981	10	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	8594	2857	0	UNDEFINED	-3981	10	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	934	2857	0	UNDEFINED	-3981	10	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	135398745	2893	112	3H-SCH23390	-26	66	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-SCH23390	-26	66	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-SCH23390	-26	66	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-SCH23390	-26	66	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	6603820	95745	19	3H-SCH23390	-4	13	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	CHEMBL25856	95745	19	3H-SCH23390	-4	13	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	10707972	169032	0	UNDEFINED	1	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
	CHEMBL439639	169032	0	UNDEFINED	1	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	UNDEFINED	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	UNDEFINED	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	UNDEFINED	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	UNDEFINED	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	UNDEFINED	-83	92	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	2470	3626	50	3H-SCH23390	-51286	60	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-SCH23390	-51286	60	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-SCH23390	-51286	60	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-SCH23390	-51286	60	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-SCH23390	-51286	60	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	1353	1898	93	3H-SCH23390	-38	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-38	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-38	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-38	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-38	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	73453	29585	24	3H-dopamine	-51	17	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
	CHEMBL1385840	29585	24	3H-dopamine	-51	17	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
	2470	3626	50	3H-SCH23390	-10964	60	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-SCH23390	-10964	60	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-SCH23390	-10964	60	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-SCH23390	-10964	60	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-SCH23390	-10964	60	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	25293	215940	0	3H-dopamine	-724	4	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	443	6	1	3	5.4	C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(=O)C3=CC=C(C=C3)F	None
	44448059	94791	0	UNDEFINED	5	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
	CHEMBL253530	94791	0	UNDEFINED	5	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
	25058166	215935	0	3H-SCH23390	-144	27	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-SCH23390	-144	27	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	213	3824	55	3H-SCH23390	-12	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3824	55	3H-SCH23390	-12	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3824	55	3H-SCH23390	-12	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3824	55	3H-SCH23390	-12	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3824	55	3H-SCH23390	-12	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	681	1453	72	3H-SCH23390	-97	39	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-SCH23390	-97	39	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-SCH23390	-97	39	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-SCH23390	-97	39	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-SCH23390	-97	39	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	13994416	190666	1	UNDEFINED	-851	2	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1C(C2)N(C)CC3	None
	CHEMBL5181992	190666	1	UNDEFINED	-851	2	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1C(C2)N(C)CC3	None
	5018	3523	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	943	3523	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	946	3523	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	CHEMBL13668	3523	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	5770	205035	82	3H-SCH23390	-2	7	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
	CHEMBL772	205035	82	3H-SCH23390	-2	7	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
	242	469	124	3H-SCH23390	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-SCH23390	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-SCH23390	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-SCH23390	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-SCH23390	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	2337	3232	77	UNDEFINED	-134	63	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	UNDEFINED	-134	63	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	UNDEFINED	-134	63	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	UNDEFINED	-134	63	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	UNDEFINED	-134	63	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	1524	2168	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	5281878	1647	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	37459	743	13	3H-SCH23390	-10	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-SCH23390	-10	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-SCH23390	-10	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	1577	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3677	110	None	-50	26	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5281878	1647	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2402	3345	62	None	-74	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	5095	3345	62	None	-74	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	7295	3345	62	None	-74	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	CHEMBL589	3345	62	None	-74	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	DB00268	3345	62	None	-74	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	1212	1649	50	3H-SCH23390	-8	66	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1212	1649	50	3H-SCH23390	-14	66	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-SCH23390	-8	66	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-SCH23390	-14	66	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-SCH23390	-8	66	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-SCH23390	-14	66	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-SCH23390	-8	66	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-SCH23390	-14	66	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-SCH23390	-8	66	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-SCH23390	-14	66	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	10742	3590	31	3H-SCH23390	2	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
	1225	3590	31	3H-SCH23390	2	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
	CHEMBL35354	3590	31	3H-SCH23390	2	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
	6603820	95745	19	3H-SCH23390	1	13	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	CHEMBL25856	95745	19	3H-SCH23390	1	13	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	2662	11352	131	None	-3	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	CHEMBL118	11352	131	None	-3	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	441383	20301	57	None	-12	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	CHEMBL1306	20301	57	None	-12	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	28417	40009	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
	CHEMBL1479	40009	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
	2105	3032	37	3H-SCH23390	-645	33	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	2105	3032	37	3H-SCH23390	-645	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	3H-SCH23390	-645	33	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	3H-SCH23390	-645	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	3H-SCH23390	-645	33	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	3H-SCH23390	-645	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	3H-SCH23390	-645	33	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	3H-SCH23390	-645	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	3H-SCH23390	-645	33	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	3H-SCH23390	-645	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	25058166	215935	0	3H-SCH23390	-144	27	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-SCH23390	-144	27	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	4011	82379	49	UNDEFINED	-64	24	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	CHEMBL21731	82379	49	UNDEFINED	-64	24	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	135398737	955	93	3H-SCH23390	-169	92	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-169	92	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-169	92	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-169	92	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-169	92	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	5018	3523	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	943	3523	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	946	3523	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	CHEMBL13668	3523	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
	115237	55555	119	3H-SCH23390	-74	55	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55555	119	3H-SCH23390	-74	55	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	1242	3586	27	3H-SCH23390	1	18	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	3H-SCH23390	1	18	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	3H-SCH23390	1	18	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	242	469	124	3H-SCH23390	-74	52	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-SCH23390	-74	52	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-SCH23390	-74	52	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-SCH23390	-74	52	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-SCH23390	-74	52	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	16363	593	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	312	593	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	9215	593	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL297302	593	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB12867	593	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	16362	3103	71	3H-dopamine	-30199	30	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3103	71	3H-dopamine	-30199	30	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3103	71	3H-dopamine	-30199	30	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3103	71	3H-dopamine	-30199	30	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3103	71	3H-dopamine	-30199	30	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	1816	2523	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	4205	2523	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	7241	2523	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	CHEMBL654	2523	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	DB00370	2523	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	3294	1993	111	3H-SCH23390	-56	45	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	3H-SCH23390	-56	45	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	3H-SCH23390	-56	45	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	3H-SCH23390	-56	45	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	3H-SCH23390	-56	45	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	2337	3232	77	3H-SCH23390	-134	63	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-SCH23390	-134	63	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-SCH23390	-134	63	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-SCH23390	-134	63	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-SCH23390	-134	63	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	135	2515	43	3H-MIANSERIN	-91	58	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-MIANSERIN	-91	58	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-MIANSERIN	-91	58	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-MIANSERIN	-91	58	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-MIANSERIN	-91	58	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	44448070	94864	0	UNDEFINED	3	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	None
	CHEMBL254147	94864	0	UNDEFINED	3	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	None
	25186021	188000	0	UNDEFINED	-1318	3	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	None
	CHEMBL497574	188000	0	UNDEFINED	-1318	3	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	None
	25058166	215935	0	3H-SCH23390	-147	27	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-SCH23390	-147	27	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	11712530	187866	0	UNDEFINED	-41686	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	None
	CHEMBL496531	187866	0	UNDEFINED	-41686	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	None
	2726	916	68	3H-SCH23390	-36	73	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-SCH23390	-36	73	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-SCH23390	-36	73	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-SCH23390	-36	73	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-SCH23390	-36	73	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	209	3035	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	3035	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	3035	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	3035	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	3035	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	None	216540	0	UNDEFINED	-549	6	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
	681	1453	72	3H-SCH23390	-154	39	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-SCH23390	-154	39	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-SCH23390	-154	39	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-SCH23390	-154	39	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-SCH23390	-154	39	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	1222	1651	49	3H-SCH23390	-741	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3396	1651	49	3H-SCH23390	-741	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	85	1651	49	3H-SCH23390	-741	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL46516	1651	49	3H-SCH23390	-741	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	DB04842	1651	49	3H-SCH23390	-741	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	None	215946	0	3H-SCH23390	-9772	15	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	2337	3232	77	3H-SCH23390	-134	63	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-SCH23390	-134	63	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-SCH23390	-134	63	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-SCH23390	-134	63	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-SCH23390	-134	63	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	135398745	2893	112	3H-SCH23390	-23	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-SCH23390	-23	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-SCH23390	-23	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-SCH23390	-23	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	None	216748	0	UNDEFINED	1	4	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.2	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
	None	216748	0	UNDEFINED	-1	4	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.2	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
	25186569	176958	0	UNDEFINED	-45708	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	None
	CHEMBL462508	176958	0	UNDEFINED	-45708	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	None
	None	216206	0	3H-SCH23390	-11	4	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	226	0	2	2	1.4	C1CCC(=O)NCCCCCC(=O)NCC1	None
	1524	2168	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	219050	3348	25	3H-SCH23390	-2884	21	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
	52	3348	25	3H-SCH23390	-2884	21	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
	CHEMBL431367	3348	25	3H-SCH23390	-2884	21	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
	5281878	1647	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281878	1647	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	30137	2857	0	3H-SCH23390	-1202	10	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	8594	2857	0	3H-SCH23390	-1202	10	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	934	2857	0	3H-SCH23390	-1202	10	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	6446379	216259	0	3H-dopamine	-154	2	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	472	5	1	4	5.1	C1CN(CCN1CC/C=C/2\C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO.Cl.Cl	None
	10264969	48265	0	UNDEFINED	-6	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
	CHEMBL155352	48265	0	UNDEFINED	-6	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
	None	216712	0	UNDEFINED	-	1	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	405	2	2	5	3.6	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O)Br	None
	2181	3106	46	3H-dopamine	-4073	35	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	4830	3106	46	3H-dopamine	-4073	35	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	92	3106	46	3H-dopamine	-4073	35	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	CHEMBL440294	3106	46	3H-dopamine	-4073	35	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	DB09286	3106	46	3H-dopamine	-4073	35	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	None	216540	0	UNDEFINED	-549	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
	46780481	107504	20	3H-SCH23390	-64	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107504	20	3H-SCH23390	-64	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107504	20	3H-SCH23390	-64	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107504	20	3H-SCH23390	-64	54	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	64143	198841	62	None	-1	8	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	None
	CHEMBL584	198841	62	None	-1	8	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	None
	2477	742	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	742	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	742	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	742	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	742	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	2780	110502	36	None	-138	11	Bovine	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	Drug Central	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
	CHEMBL325109	110502	36	None	-138	11	Bovine	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	Drug Central	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
	176	397	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	397	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	397	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	397	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	397	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	3198	205490	76	None	-31	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1201049	205490	76	None	-31	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL808	205490	76	None	-31	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	2812	4747	101	None	-32	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	CHEMBL104	4747	101	None	-32	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	1016	3720	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2561	3720	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2733526	3720	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	5384	3720	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	CHEMBL83	3720	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	DB00675	3720	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	1816	2523	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	4205	2523	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	7241	2523	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	CHEMBL654	2523	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	DB00370	2523	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	1816	2523	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	4205	2523	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	7241	2523	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	CHEMBL654	2523	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	DB00370	2523	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	448537	160226	89	None	-28	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
	CHEMBL411	160226	89	None	-28	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
	4189	206899	96	None	-25	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL1559	206899	96	None	-25	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL91	206899	96	None	-25	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	1042	1568	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	148	1568	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	443884	1568	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	CHEMBL119443	1568	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	DB01253	1568	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	2407	3347	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
	59227	3347	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
	941	3347	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
	CHEMBL1303	3347	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
	DB05271	3347	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
	5353853	17954	47	None	-19	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	9556529	17954	47	None	-19	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL1262	17954	47	None	-19	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	11154555	797	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	5037	797	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	7671	797	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL2028019	797	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL3085826	797	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB06016	797	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	2247	504	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	249	504	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	2603	504	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	CHEMBL296419	504	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	DB00637	504	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	12488	1644	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	941361	1644	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	CHEMBL30008	1644	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	DB04841	1644	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	2351	3261	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	2820	3261	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	5035	3261	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	CHEMBL81	3261	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	DB00481	3261	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	240	941	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	941	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	941	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	941	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	941	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	941	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	941	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	1830	2572	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2572	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2572	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2572	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2572	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	None	216357	0	3H-SCH23390	1737	2	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	2	1	5	2.9	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OCC4)O)[N+](=O)[O-]	None
	11057	176125	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	3468	176125	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	CHEMBL459265	176125	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	CHEMBL64894	176125	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	135	2515	43	None	-46	58	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	None	-46	58	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	None	-46	58	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	None	-46	58	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	None	-46	58	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2286	3161	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	4927	3161	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	7282	3161	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	CHEMBL643	3161	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	DB01069	3161	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	2600	3750	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	2608	3750	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	5405	3750	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	CHEMBL17157	3750	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	DB00342	3750	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	6917970	3665	61	3H-SCH23390	-1	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	8370	3665	61	3H-SCH23390	-1	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	CHEMBL487387	3665	61	3H-SCH23390	-1	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	2284	3160	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	4926	3160	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	7281	3160	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	CHEMBL564	3160	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	DB00420	3160	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	10531	1408	21	None	-218	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	121	1408	21	None	-218	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	888	1408	21	None	-218	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	CHEMBL1732	1408	21	None	-218	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	DB00320	1408	21	None	-218	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	3117	207818	103	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
	CHEMBL964	207818	103	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
	2389	3306	118	UNDEFINED	-346	68	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	UNDEFINED	-346	68	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	UNDEFINED	-346	68	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	UNDEFINED	-346	68	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	UNDEFINED	-346	68	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	3947	206372	53	3H-SCH23390	-74	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
	CHEMBL87708	206372	53	3H-SCH23390	-74	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
	5	139	72	3H-SCH23390	-16595	55	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-SCH23390	-16595	55	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-SCH23390	-16595	55	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-SCH23390	-16595	55	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	None	216208	0	3H-SCH23390	-6	6	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	255	2	1	2	2.4	CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl	None
	None	216208	0	3H-SCH23390	-6	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	255	2	1	2	2.4	CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl	None
	11954259	215954	0	3H-SCH23390	-169	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	681	1453	72	3H-SCH23390 High	-23	39	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-SCH23390 High	-23	39	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-SCH23390 High	-23	39	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-SCH23390 High	-23	39	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-SCH23390 High	-23	39	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	115237	55555	119	3H-SCH23390	-2511	55	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55555	119	3H-SCH23390	-2511	55	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	3153	296	28	3H-SCH23390	-3019	8	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	932	296	28	3H-SCH23390	-3019	8	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	CHEMBL26736	296	28	3H-SCH23390	-3019	8	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
	135398745	2893	112	UNDEFINED	-26	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	UNDEFINED	-26	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	UNDEFINED	-26	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	UNDEFINED	-26	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	31116	216257	0	3H-dopamine	-37	2	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	609	5	3	6	2.6	CC(C)C1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	135398745	2893	112	3H-SCH233930	-26	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-SCH233930	-26	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-SCH233930	-26	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-SCH233930	-26	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	None	216710	0	UNDEFINED	-	1	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	433	4	0	5	4.2	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC)Br	None
	2389	3306	118	3H-SCH23390	-489	68	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-SCH23390	-489	68	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-SCH23390	-489	68	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-SCH23390	-489	68	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-SCH23390	-489	68	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	None	217244	0	UNDEFINED	-	1	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	323	2	0	4	3.4	CC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)C)OC	None
	135398737	955	93	UNDEFINED	-83	92	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	UNDEFINED	-83	92	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	UNDEFINED	-83	92	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	UNDEFINED	-83	92	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	UNDEFINED	-83	92	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	5568	197477	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
	66069	197477	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
	CHEMBL1201102	197477	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
	CHEMBL570	197477	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
	16362	3103	71	3H-dopamine	-30199	30	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3103	71	3H-dopamine	-30199	30	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3103	71	3H-dopamine	-30199	30	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3103	71	3H-dopamine	-30199	30	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3103	71	3H-dopamine	-30199	30	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	185	3975	60	3H-SCH23390	-6606	38	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	5311271	3975	60	3H-SCH23390	-6606	38	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	CHEMBL74355	3975	60	3H-SCH23390	-6606	38	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	DB16351	3975	60	3H-SCH23390	-6606	38	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	135398737	955	93	3H-SCH23390	-44	92	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-44	92	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-44	92	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-44	92	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-44	92	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1613	2333	53	3H-SCH23390	-5	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-SCH23390	-5	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-SCH23390	-5	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-SCH23390	-5	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-SCH23390	-5	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	11954259	215954	0	3H-dopamine	-7762	44	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	None	216540	0	UNDEFINED	-549	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
	3294	1993	111	3H-SCH23390	-794	45	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	3H-SCH23390	-794	45	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	3H-SCH23390	-794	45	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	3H-SCH23390	-794	45	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	3H-SCH23390	-794	45	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	2995	204382	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204382	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204382	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	2995	204382	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204382	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204382	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	135398737	955	93	3H-SCH23390	-22	92	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-22	92	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-22	92	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-22	92	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-22	92	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	2389	3306	118	3H-SCH23390	-346	68	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-SCH23390	-346	68	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-SCH23390	-346	68	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-SCH23390	-346	68	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-SCH23390	-346	68	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	11654739	176824	0	UNDEFINED	-20417	4	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	None
	CHEMBL461236	176824	0	UNDEFINED	-20417	4	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	None
	1242	3586	27	125I-SCH 23982	-5	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	125I-SCH 23982	-5	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	125I-SCH 23982	-5	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	24949693	182280	0	UNDEFINED	-7244	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
	CHEMBL478413	182280	0	UNDEFINED	-7244	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	2389	3306	118	3H-SCH233930	-489	68	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-SCH233930	-489	68	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-SCH233930	-489	68	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-SCH233930	-489	68	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-SCH233930	-489	68	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2470	3626	50	3H-SCH23390	-4168	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-SCH23390	-4168	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-SCH23390	-4168	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-SCH23390	-4168	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-SCH23390	-4168	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	1353	1898	93	3H-SCH23390	-38	86	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-38	86	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-38	86	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-38	86	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-38	86	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	135398745	2893	112	3H-SCH23390	-26	66	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-SCH23390	-26	66	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-SCH23390	-26	66	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-SCH23390	-26	66	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2389	3306	118	UNDEFINED	-489	68	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	UNDEFINED	-489	68	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	UNDEFINED	-489	68	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	UNDEFINED	-489	68	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	UNDEFINED	-489	68	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	100	3776	58	3H-SCH23390	-16	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-SCH23390	-16	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-SCH23390	-16	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-SCH23390	-16	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-SCH23390	-16	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	None	216301	0	3H-SCH23390	16	28	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
	135	2515	43	None	-91	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	None	-91	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	None	-91	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	None	-91	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	None	-91	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	None	216707	0	UNDEFINED	-	1	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	467	3	1	5	3.8	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)O)I	None
	11954224	215928	0	None	-3467	60	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	242	469	124	None	-281	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	None	-281	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	None	-281	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	None	-281	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	None	-281	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	26987	946	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	6063	946	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	671	946	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	CHEMBL1626	946	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	DB00283	946	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	2585	800	103	None	-112	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	522	800	103	None	-112	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	551	800	103	None	-112	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	CHEMBL723	800	103	None	-112	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	DB01136	800	103	None	-112	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	31101	726	40	None	-436	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	None	-436	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	None	-436	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	None	-436	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	None	-436	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	6603820	95745	19	3H-SCH23390	1	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	CHEMBL25856	95745	19	3H-SCH23390	1	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	3191	102831	97	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	CHEMBL305660	102831	97	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	107715	200922	22	None	-144	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
	CHEMBL1255837	200922	22	None	-144	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
	CHEMBL601773	200922	22	None	-144	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
	3168	9230	92	None	-89	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
	CHEMBL1108	9230	92	None	-89	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
	150	2492	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	1764	2492	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	8226	2492	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	CHEMBL1201356	2492	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	DB00353	2492	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	2407	3347	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
	59227	3347	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
	941	3347	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
	CHEMBL1303	3347	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
	DB05271	3347	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
	5440	28693	37	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
	CHEMBL1378	28693	37	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
	4011	82379	49	None	-64	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	CHEMBL21731	82379	49	None	-64	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	134	2497	24	None	-263	68	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	None	-263	68	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	None	-263	68	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	None	-263	68	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	None	-263	68	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1530	2169	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	3827	2169	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	7206	2169	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	CHEMBL534	2169	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	DB00920	2169	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	68663	27251	23	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	None
	CHEMBL136711	27251	23	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	None
	135398737	955	93	None	-204	92	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	None	-204	92	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	None	-204	92	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	None	-204	92	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	None	-204	92	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	None	-37	92	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	None	-37	92	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	None	-37	92	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	None	-37	92	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	None	-37	92	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	2337	3232	77	None	-53	63	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	None	-53	63	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	None	-53	63	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	None	-53	63	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	None	-53	63	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	7077	66929	27	None	-3	5	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	Drug Central	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	None
	CHEMBL186720	66929	27	None	-3	5	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	Drug Central	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	None
	CHEMBL3925724	66929	27	None	-3	5	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	Drug Central	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	None
	2105	3032	37	None	-537	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	None	-537	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	None	-537	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	None	-537	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	None	-537	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	2470	3626	50	None	-4168	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	None	-4168	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	None	-4168	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	None	-4168	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	None	-4168	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3561	19045	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
	CHEMBL1289	19045	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
	1971	2846	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	2404	2846	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	4543	2846	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	CHEMBL445	2846	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	DB00540	2846	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	5462328	217709	0	None	1	3	Rat	8.2	pKi	=	8.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	Drug Central	369	2	0	6	2.0	CN1CC[C@]23[C@H]4OC5=C(OC(C)=O)C=CC(C[C@@H]1[C@@H]2C=C[C@@H]4OC(C)=O)=C35	None
	2398	951	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	2801	951	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	701	951	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	CHEMBL415	951	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	DB01242	951	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	3294	1993	111	None	-56	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	None	-56	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	None	-56	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	None	-56	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	None	-56	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	2435	3563	83	None	-72	49	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	None	-72	49	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	None	-72	49	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	None	-72	49	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	None	-72	49	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	134551	357	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	271	357	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	885	357	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	CHEMBL1403281	357	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	37	775	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	460	775	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	54746	775	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	CHEMBL1201087	775	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	DB00248	775	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	1524	2168	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	191	402	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	402	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	402	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	402	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	402	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	1621	2413	17	None	-112	45	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	None	-112	45	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	None	-112	45	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	None	-112	45	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	None	-112	45	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	11978813	718	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	5014	718	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	7672	718	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	CHEMBL2105760	718	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	DB09128	718	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	681	1453	72	None	-97	39	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	None	-97	39	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	None	-97	39	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	None	-97	39	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	None	-97	39	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	33630	178933	99	None	-5	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL47050	178933	99	None	-5	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	52919	14418	48	None	-15	4	Pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	CHEMBL1200986	14418	48	None	-15	4	Pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	135398737	955	93	None	-44	92	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	None	-44	92	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	None	-44	92	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	None	-44	92	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	None	-44	92	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	277	1289	62	None	-47	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	None	-47	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	None	-47	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	None	-47	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	None	-47	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	1712	2475	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2475	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2475	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2475	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2475	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	2389	3306	118	3H-SCH23390	-489	68	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-SCH23390	-489	68	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-SCH23390	-489	68	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-SCH23390	-489	68	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-SCH23390	-489	68	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2448	99295	70	3H-dopamine	-426	18	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL28218	99295	70	3H-dopamine	-426	18	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	1042	1568	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	148	1568	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	443884	1568	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	CHEMBL119443	1568	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	DB01253	1568	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	None	216749	0	UNDEFINED	-2	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	251	0	1	2	3.1	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)O	None
	10265732	94820	0	UNDEFINED	2	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
	CHEMBL253738	94820	0	UNDEFINED	2	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
	2389	3306	118	3H-SCH23390	-346	68	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-SCH23390	-346	68	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-SCH23390	-346	68	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-SCH23390	-346	68	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-SCH23390	-346	68	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	185	3975	60	3H-SCH23390	-6606	38	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	5311271	3975	60	3H-SCH23390	-6606	38	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	CHEMBL74355	3975	60	3H-SCH23390	-6606	38	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	DB16351	3975	60	3H-SCH23390	-6606	38	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	44448063	155221	0	UNDEFINED	3	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
	CHEMBL402736	155221	0	UNDEFINED	3	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
	68617	205504	62	3H-SCH23390	-912	26	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL1709	205504	62	3H-SCH23390	-912	26	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL809	205504	62	3H-SCH23390	-912	26	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	1242	3586	27	125I-SCH 23982	1	18	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	125I-SCH 23982	1	18	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	125I-SCH 23982	1	18	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	1588	2311	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	10355510	155638	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
	CHEMBL404865	155638	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
	None	216703	0	UNDEFINED	-	1	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	325	3	2	4	3.6	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=C(C=C4)O)O	None
	1353	1898	93	3H-dopamine	-512	86	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-dopamine	-512	86	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-dopamine	-512	86	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-dopamine	-512	86	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-dopamine	-512	86	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	44448061	94818	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
	CHEMBL253736	94818	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
	None	217340	0	UNDEFINED	-	1	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	3	2	3	5.7	CCCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5.Cl	None
	20840341	216151	0	3H-dopamine	-75	4	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	451	5	1	3	6.2	C1CN(CCC1CCO)CCC=C2C3=C(C=C(C=C3)F)SC4=C2C=C(C=C4)C(F)(F)F	None
	115237	55555	119	3H-SCH23390	-2511	55	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55555	119	3H-SCH23390	-2511	55	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	31101	726	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	25058166	215935	0	3H-SCH23390	-144	27	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-SCH23390	-144	27	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	16362	3103	71	3H-dopamine	-30199	30	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3103	71	3H-dopamine	-30199	30	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3103	71	3H-dopamine	-30199	30	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3103	71	3H-dopamine	-30199	30	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3103	71	3H-dopamine	-30199	30	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	10660476	47343	0	UNDEFINED	-	1	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
	CHEMBL154468	47343	0	UNDEFINED	-	1	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
	134551	357	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	271	357	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	885	357	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	CHEMBL1403281	357	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	135398745	2893	112	UNDEFINED	-23	66	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	UNDEFINED	-23	66	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	UNDEFINED	-23	66	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	UNDEFINED	-23	66	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	31101	726	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	127708	112494	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
	CHEMBL329904	112494	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
	228	444	28	None	-4	24	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	33	444	28	None	-4	24	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	6005	444	28	None	-4	24	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	CHEMBL53	444	28	None	-4	24	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	DB00714	444	28	None	-4	24	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	2448	99295	70	None	-5	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL28218	99295	70	None	-5	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	1212	1649	50	3H-SCH23390	-51	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-SCH23390	-51	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-SCH23390	-51	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-SCH23390	-51	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-SCH23390	-51	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1353	1898	93	None	-30	86	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	None	-30	86	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	None	-30	86	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	None	-30	86	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	None	-30	86	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	180	400	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	1588	2311	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2274	3151	58	None	-16	32	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3151	58	None	-16	32	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3151	58	None	-16	32	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3151	58	None	-16	32	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3151	58	None	-16	32	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2726	916	68	None	-36	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	None	-36	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	None	-36	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	None	-36	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	None	-36	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	25058166	215935	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	1613	2333	53	None	-5	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	None	-5	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	None	-5	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	None	-5	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	None	-5	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	228	444	28	None	-30	24	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	33	444	28	None	-30	24	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	6005	444	28	None	-30	24	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	CHEMBL53	444	28	None	-30	24	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	DB00714	444	28	None	-30	24	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	212	3777	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	2639	3777	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	941651	3777	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	CHEMBL1201	3777	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	DB01623	3777	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	135398737	955	93	None	-83	92	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	None	-83	92	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	None	-83	92	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	None	-83	92	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	None	-83	92	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	21302490	112778	32	None	-8	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	None
	CHEMBL3233142	112778	32	None	-8	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	None
	CHEMBL3306803	112778	32	None	-8	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	None
	115237	55555	119	None	-74	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55555	119	None	-74	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	135398745	2893	112	None	-26	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	None	-26	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	None	-26	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	None	-26	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	133	2479	52	None	-30	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	None	-30	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	None	-30	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	None	-30	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	None	-30	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2726	916	68	None	-18	73	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	None	-18	73	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	None	-18	73	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	None	-18	73	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	None	-18	73	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	103	4122	61	None	-28	54	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	None	-28	54	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	None	-28	54	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	None	-28	54	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	None	-28	54	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	1212	1649	50	None	-51	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	None	-51	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	None	-51	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	None	-51	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	None	-51	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2389	3306	118	None	-346	68	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	None	-346	68	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	None	-346	68	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	None	-346	68	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	None	-346	68	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2389	3306	118	None	-489	68	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	None	-489	68	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	None	-489	68	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	None	-489	68	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	None	-489	68	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	3389	217683	0	None	-1	26	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
	1353	1898	93	None	-74	86	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	None	-74	86	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	None	-74	86	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	None	-74	86	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	None	-74	86	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	135398745	2893	112	None	-23	66	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	None	-23	66	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	None	-23	66	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	None	-23	66	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	11976	917	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	917	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	917	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	917	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	5281878	1647	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	6761	67770	19	None	-5	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL1909072	67770	19	None	-5	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
	1353	1898	93	None	-38	86	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	None	-38	86	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	None	-38	86	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	None	-38	86	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	None	-38	86	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	16351	102703	47	None	-4	6	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL304902	102703	47	None	-4	6	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	2435	3563	83	None	-43	49	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	None	-43	49	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	None	-43	49	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	None	-43	49	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	None	-43	49	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	37459	743	13	3H-dopamine	-53	25	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-dopamine	-53	25	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-dopamine	-53	25	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	127708	112494	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
	CHEMBL329904	112494	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
	7153	97992	77	3H-SCH23390	-371	34	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-SCH23390	-371	34	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	103	4122	61	3H-SCH23390	-28	54	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-SCH23390	-28	54	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-SCH23390	-28	54	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-SCH23390	-28	54	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-SCH23390	-28	54	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2284	3160	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	4926	3160	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	7281	3160	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	CHEMBL564	3160	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	DB00420	3160	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	2337	3232	77	3H-SCH23390	-53	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-SCH23390	-53	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-SCH23390	-53	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-SCH23390	-53	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-SCH23390	-53	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	25186023	187720	0	UNDEFINED	-50118	4	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	None
	CHEMBL495572	187720	0	UNDEFINED	-50118	4	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	None
	25058166	215935	0	UNDEFINED	-144	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	UNDEFINED	-144	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	44448067	155505	0	UNDEFINED	-	1	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	None
	CHEMBL404240	155505	0	UNDEFINED	-	1	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	None
	5281878	1647	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2726	916	68	3H-SCH23390	-36	73	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-SCH23390	-36	73	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-SCH23390	-36	73	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-SCH23390	-36	73	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-SCH23390	-36	73	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	1241	100151	24	3H-SCH23390	-2	8	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
	CHEMBL288090	100151	24	3H-SCH23390	-2	8	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
	CHEMBL552611	100151	24	3H-SCH23390	-2	8	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
	30137	2857	0	UNDEFINED	-3981	10	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	8594	2857	0	UNDEFINED	-3981	10	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	934	2857	0	UNDEFINED	-3981	10	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
	2726	916	68	3H-SCH23390	-18	73	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-SCH23390	-18	73	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-SCH23390	-18	73	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-SCH23390	-18	73	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-SCH23390	-18	73	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	214	3831	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3831	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3831	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3831	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3831	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3831	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5567	42772	27	3H-dopamine	-812	8	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
	CHEMBL15023	42772	27	3H-dopamine	-812	8	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
	2389	3306	118	3H-SCH23390	-346	68	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-SCH23390	-346	68	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-SCH23390	-346	68	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-SCH23390	-346	68	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-SCH23390	-346	68	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	100	3776	58	3H-SCH23390	-309	56	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-SCH23390	-309	56	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-SCH23390	-309	56	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-SCH23390	-309	56	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-SCH23390	-309	56	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	None	217111	0	UNDEFINED	-199	2	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	359	1	3	4	4.2	CN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=C(C=C5)O	None
	1353	1898	93	3H-SCH23390	-52	86	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-52	86	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-52	86	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-52	86	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-52	86	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	None	216388	0	3H-SCH23390	-691	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	453	8	1	4	4.6	COC1=CC=CC=C1N2CCN(CC2)CCCCNC(=O)C3=CC4=CC=CC=C4C=C3.Cl	None
	16362	3103	71	3H-dopamine	-30199	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3103	71	3H-dopamine	-30199	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3103	71	3H-dopamine	-30199	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3103	71	3H-dopamine	-30199	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3103	71	3H-dopamine	-30199	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2470	3626	50	3H-SCH23390	-31622	60	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-SCH23390	-31622	60	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-SCH23390	-31622	60	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-SCH23390	-31622	60	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-SCH23390	-31622	60	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	681	1453	72	3H-SCH23390	-1548	39	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-SCH23390	-1548	39	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-SCH23390	-1548	39	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-SCH23390	-1548	39	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-SCH23390	-1548	39	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	None	216931	0	UNDEFINED	8	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	1	1	3	3.0	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)N	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	2107	3033	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
	4747	3033	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
	9216	3033	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
	CHEMBL251940	3033	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
	DB01608	3033	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
	25058166	215935	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	2865	4112	73	None	-114	54	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	None	-114	54	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	None	-114	54	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	None	-114	54	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	None	-114	54	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	681	1453	72	None	-23	39	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	None	-23	39	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	None	-23	39	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	None	-23	39	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	None	-23	39	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	228	444	28	None	-35	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	33	444	28	None	-35	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	6005	444	28	None	-35	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	CHEMBL53	444	28	None	-35	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	DB00714	444	28	None	-35	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	5281878	1647	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	62865	1263	0	None	-2	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	746	1263	0	None	-2	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	84	1263	0	None	-2	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	CHEMBL2104153	1263	0	None	-2	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	DB09000	1263	0	None	-2	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	1153	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	12668023	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	30026874	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	30026875	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	3341	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	6603851	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	933	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	939	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	985	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL1160786	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL1161520	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL588	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	DB00800	1615	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	25058166	215935	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	1238	203151	24	None	-5	17	Rat	8.1	pKi	=	8.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	Drug Central	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL64249	203151	24	None	-5	17	Rat	8.1	pKi	=	8.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	Drug Central	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	46780481	107504	20	None	-29	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107504	20	None	-29	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107504	20	None	-29	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107504	20	None	-29	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	37459	743	13	3H-dopamine	-53	25	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-dopamine	-53	25	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-dopamine	-53	25	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	15139	199057	52	3H-dopamine	-794	5	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	356	7	0	4	3.6	COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	CHEMBL58792	199057	52	3H-dopamine	-794	5	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	356	7	0	4	3.6	COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	16219195	216105	0	3H-dopamine	1	5	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	325	1	1	5	2.9	CN1CCC2=CC3=C(C4=C2C1CC5=C4C(=C(C=C5)OC)O)OCO3	None
	None	216698	0	UNDEFINED	-	1	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	325	4	0	3	3.9	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)F)C(=CC=C4)OC=O	None
	5281878	1647	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	180	400	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	1353	1898	93	3H-SCH23390	-38	86	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-38	86	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-38	86	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-38	86	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-38	86	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	484	2837	51	3H-dopamine	-4	36	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2837	51	3H-dopamine	-4	36	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2837	51	3H-dopamine	-4	36	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	2780	110502	36	3H-SCH23390	-630	11	Mouse	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
	CHEMBL325109	110502	36	3H-SCH23390	-630	11	Mouse	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
	1353	1898	93	3H-SCH23390	-38	86	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-38	86	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-38	86	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-38	86	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-38	86	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	44448064	94845	0	UNDEFINED	1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
	CHEMBL253947	94845	0	UNDEFINED	1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
	1353	1898	93	3H-SCH23390	-74	86	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-SCH23390	-74	86	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-SCH23390	-74	86	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-SCH23390	-74	86	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-SCH23390	-74	86	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL146246	38248	0	3H-SCH23390	-2290	10	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	401	5	1	5	2.2	NS(=O)(=O)c1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	None
	103	4122	61	3H-SCH23390	-69	54	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-SCH23390	-69	54	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-SCH23390	-69	54	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-SCH23390	-69	54	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-SCH23390	-69	54	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2470	3626	50	3H-SCH23390	-51286	60	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-SCH23390	-51286	60	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-SCH23390	-51286	60	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-SCH23390	-51286	60	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-SCH23390	-51286	60	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	279	1648	26	3H-SCH23390	-17	18	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	49381	1648	26	3H-SCH23390	-17	18	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	CHEMBL63756	1648	26	3H-SCH23390	-17	18	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	135398745	2893	112	3H-SCH23390	-23	66	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-SCH23390	-23	66	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-SCH23390	-23	66	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-SCH23390	-23	66	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	44448060	155220	0	UNDEFINED	-1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	None
	CHEMBL402735	155220	0	UNDEFINED	-1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	None
	None	217106	0	UNDEFINED	-269	11	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	116	4	0	2	1.4	CCCCN(C)N=O	None
	25058166	215935	0	3H-SCH23390	-147	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-SCH23390	-147	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	135398737	955	93	3H-SCH23390	-83	92	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-SCH23390	-83	92	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-SCH23390	-83	92	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-SCH23390	-83	92	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-SCH23390	-83	92	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	44591012	175556	0	UNDEFINED	-177	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	None
	CHEMBL457957	175556	0	UNDEFINED	-177	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	None
	None	217110	0	UNDEFINED	1	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	343	1	2	3	4.5	CN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5	None
	3168	9230	92	3H-dopamine	-1318	22	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
	CHEMBL1108	9230	92	3H-dopamine	-1318	22	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
	180	400	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	135398737	955	93	UNDEFINED	-44	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	UNDEFINED	-44	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	UNDEFINED	-44	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	UNDEFINED	-44	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	UNDEFINED	-44	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	100	3776	58	3H-SCH23390	-47	56	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-SCH23390	-47	56	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-SCH23390	-47	56	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-SCH23390	-47	56	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-SCH23390	-47	56	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	681	1453	72	None	-154	39	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	None	-154	39	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	None	-154	39	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	None	-154	39	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	None	-154	39	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	242	469	124	None	-74	52	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	None	-74	52	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	None	-74	52	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	None	-74	52	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	None	-74	52	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	37459	743	13	3H-SCH23390	-21	25	Rhesus macaque	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-SCH23390	-21	25	Rhesus macaque	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-SCH23390	-21	25	Rhesus macaque	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	2865	4112	73	UNDEFINED	-114	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	UNDEFINED	-114	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	UNDEFINED	-114	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	UNDEFINED	-114	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	UNDEFINED	-114	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	6603820	95745	19	3H-SCH23390	1	13	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	CHEMBL25856	95745	19	3H-SCH23390	1	13	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
	2726	916	68	3H-dopamine	-186	73	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-dopamine	-186	73	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-dopamine	-186	73	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-dopamine	-186	73	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-dopamine	-186	73	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	6852400	215914	0	3H-SCH23390	-22387	22	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	215914	0	3H-SCH23390	-22387	22	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	None	216109	0	3H-KETANSERIN	-9332	24	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
	5281878	1647	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5281881	1647	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	948	1647	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	968	1647	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL42055	1647	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL54661	1647	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00875	1647	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1353	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-dopamine	-512	86	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	None	216704	0	UNDEFINED	-	1	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	311	2	3	4	3.3	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)O)C(=C(C=C4)O)O	None
	24949535	181535	0	UNDEFINED	-1122	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	None
	CHEMBL476722	181535	0	UNDEFINED	-1122	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	None
	5074	3307	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	None	217341	0	UNDEFINED	-	1	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	423	3	3	4	5.4	CCCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=C(C=C5)O.Cl	None
	2726	916	68	UNDEFINED	-36	73	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	UNDEFINED	-36	73	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	UNDEFINED	-36	73	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	UNDEFINED	-36	73	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	UNDEFINED	-36	73	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	5	139	72	3H-SCH23390	-23442	55	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-SCH23390	-23442	55	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-SCH23390	-23442	55	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-SCH23390	-23442	55	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	1242	3586	27	3H-SCH23390	-5	18	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	935	3586	27	3H-SCH23390	-5	18	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	CHEMBL286080	3586	27	3H-SCH23390	-5	18	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
	5281878	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	5281878	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
	5281881	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	5281881	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
	948	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	948	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
	968	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	968	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
	CHEMBL42055	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	CHEMBL42055	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
	CHEMBL54661	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	CHEMBL54661	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
	DB00875	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	DB00875	1647	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
	681	1453	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
	681	1453	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
	940	1453	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
	940	1453	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
	947	1453	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
	947	1453	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
	CHEMBL59	1453	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
	CHEMBL59	1453	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
	DB00988	1453	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
	DB00988	1453	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
	5	139	72	None	-23442	55	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
	5202	139	72	None	-23442	55	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
	CHEMBL39	139	72	None	-23442	55	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
	DB08839	139	72	None	-23442	55	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
	1153	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	12668023	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	30026874	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	30026875	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	3341	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	6603851	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	933	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	939	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	985	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	CHEMBL1160786	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	CHEMBL1161520	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	CHEMBL588	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	DB00800	1615	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	1242	3586	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	1826762
	1242	3586	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	7525564
	935	3586	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	1826762
	935	3586	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	7525564
	CHEMBL286080	3586	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	1826762
	CHEMBL286080	3586	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	7525564
	1712	2475	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
	4078	2475	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
	7227	2475	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
	CHEMBL1088	2475	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
	DB00933	2475	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
	2274	3151	58	None	-16	32	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3151	58	None	-16	32	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3151	58	None	-16	32	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3151	58	None	-16	32	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3151	58	None	-16	32	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	1153	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	12668023	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	30026874	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	30026875	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	3341	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	6603851	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	933	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	939	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	985	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	CHEMBL1160786	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	CHEMBL1161520	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	CHEMBL588	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	DB00800	1615	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
	1153	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	12668023	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	30026874	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	30026875	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	3341	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	6603851	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	933	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	939	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	985	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	CHEMBL1160786	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	CHEMBL1161520	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	CHEMBL588	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	DB00800	1615	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
	1353	1898	93	None	-38	86	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
	1353	1898	93	None	-38	86	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
	3559	1898	93	None	-38	86	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
	3559	1898	93	None	-38	86	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
	86	1898	93	None	-38	86	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
	86	1898	93	None	-38	86	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
	CHEMBL54	1898	93	None	-38	86	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
	CHEMBL54	1898	93	None	-38	86	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
	DB00502	1898	93	None	-38	86	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
	DB00502	1898	93	None	-38	86	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
	5311070	1405	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
	9267	1405	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
	CHEMBL4280145	1405	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
	DB12890	1405	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
	2107	3033	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
	4747	3033	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
	9216	3033	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
	CHEMBL251940	3033	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
	DB01608	3033	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
	107930	1517	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
	3304	1517	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
	CHEMBL298406	1517	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
	DB12273	1517	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
	5018	3523	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
	5018	3523	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
	943	3523	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
	943	3523	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
	946	3523	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
	946	3523	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
	CHEMBL13668	3523	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
	CHEMBL13668	3523	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
	1218	3589	30	None	11	8	Rat	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	1973652
	938	3589	30	None	11	8	Rat	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	1973652
	CHEMBL353335	3589	30	None	11	8	Rat	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	1973652
	6603703	208	10	None	-1	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	17067639
	9637	208	10	None	-1	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	17067639
	CHEMBL291143	208	10	None	-1	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	17067639
	1243	3591	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	1826762
	944	3591	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	1826762
	CHEMBL324017	3591	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	1826762
	2995	204382	53	None	-23	23	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204382	53	None	-23	23	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204382	53	None	-23	23	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	5770	205035	82	None	-2	7	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
	CHEMBL772	205035	82	None	-2	7	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
	213	3824	55	None	-12	44	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3824	55	None	-12	44	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3824	55	None	-12	44	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3824	55	None	-12	44	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3824	55	None	-12	44	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2601	3751	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3751	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3751	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3751	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3751	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	484	2837	51	None	-223	36	Human	4.3	pKi	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	1826762
	951	2837	51	None	-223	36	Human	4.3	pKi	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	1826762
	CHEMBL432	2837	51	None	-223	36	Human	4.3	pKi	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	1826762
	2407	3347	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
	59227	3347	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
	941	3347	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
	CHEMBL1303	3347	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
	DB05271	3347	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
	228	444	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
	228	444	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
	33	444	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
	33	444	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
	6005	444	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
	6005	444	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
	CHEMBL53	444	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
	CHEMBL53	444	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
	DB00714	444	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
	DB00714	444	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
	3153	296	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	12388666
	3153	296	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	1826762
	932	296	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	12388666
	932	296	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	1826762
	CHEMBL26736	296	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	12388666
	CHEMBL26736	296	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	1826762
	2105	3032	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	2105	3032	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
	47811	3032	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	47811	3032	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
	48	3032	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	48	3032	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
	CHEMBL531	3032	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	CHEMBL531	3032	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
	DB01186	3032	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	DB01186	3032	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
	31101	726	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	31101	726	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
	35	726	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	35	726	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
	403	726	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	403	726	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
	CHEMBL493	726	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	CHEMBL493	726	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
	DB01200	726	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	DB01200	726	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
	937	3588	0	None	-1	2	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	1826762
	37	775	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	460	775	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	54746	775	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	CHEMBL1201087	775	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	DB00248	775	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	1524	2168	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
	197	2168	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
	3822	2168	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
	88	2168	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
	CHEMBL51	2168	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
	DB12465	2168	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
	2470	3626	50	None	-4168	60	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
	3300	3626	50	None	-4168	60	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
	5265	3626	50	None	-4168	60	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
	99	3626	50	None	-4168	60	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
	CHEMBL267930	3626	50	None	-4168	60	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
	135398737	955	93	None	-44	92	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
	38	955	93	None	-44	92	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
	722	955	93	None	-44	92	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
	CHEMBL42	955	93	None	-44	92	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
	DB00363	955	93	None	-44	92	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
	100	3776	58	None	-47	56	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
	2637	3776	58	None	-47	56	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
	5452	3776	58	None	-47	56	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
	CHEMBL479	3776	58	None	-47	56	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
	DB00679	3776	58	None	-47	56	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
	2726	916	68	None	-36	73	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
	621	916	68	None	-36	73	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
	83	916	68	None	-36	73	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
	CHEMBL71	916	68	None	-36	73	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
	DB00477	916	68	None	-36	73	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
	1588	2311	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	28864	2311	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	43	2311	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	CHEMBL157138	2311	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	DB00589	2311	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	30137	2857	0	None	-676	10	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	1826762
	8594	2857	0	None	-676	10	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	1826762
	934	2857	0	None	-676	10	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	1826762
	37459	743	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	1826762
	37459	743	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	7525564
	62	743	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	1826762
	62	743	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	7525564
	CHEMBL8514	743	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	1826762
	CHEMBL8514	743	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	7525564
	1212	1649	50	None	-51	66	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	204	1649	50	None	-51	66	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	3372	1649	50	None	-51	66	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	CHEMBL726	1649	50	None	-51	66	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	DB00623	1649	50	None	-51	66	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
	173871	3587	2	None	4	3	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	1973652
	936	3587	2	None	4	3	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	1973652
	CHEMBL1193571	3587	2	None	4	3	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	1973652

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Ligand source activities (1 row/activity)